Affinity DataKi: 0.920nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataKi: 6.90nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using pNPP as substrate incubated for 15 min by Mi...More data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Inhibition of PTP1B (1 to 321 residues) (unknown origin) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrate i...More data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constant using pNPP as substrate incubated for 15 min by Michaelis-Menten analysisMore data for this Ligand-Target Pair
Affinity DataKi: 107nMAssay Description:Inhibition of human ALR2 expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using D,L-glyceraldehyde as substrate in presence o...More data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataKi: 250nMAssay Description:Inhibition of human recombinant PTP1B (1 to 321 residues) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 270nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 290nMAssay Description:Inhibition of PTP1B (1 to 321 residues) (unknown origin) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrate i...More data for this Ligand-Target Pair
Affinity DataKi: 600nMAssay Description:Inhibition of PTP1B (1 to 321 residues) (unknown origin) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrate i...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataKi: 930nMAssay Description:Inhibition of human recombinant PTP1B (1 to 321 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using pNPP as subs...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataKi: 1.20E+3nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constant using pNPP as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of human ALR2 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constant using pNPP as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 2.50E+3nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 5.00E+3nMAssay Description:Inhibition of rat recombinant PTP1B (1 to 321 residues) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 8.00E+3nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 1.17E+4nM ΔG°: -28.1kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
Affinity DataKi: 1.17E+4nM ΔG°: -28.1kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
Affinity DataKi: 1.23E+4nM ΔG°: -28.0kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
Affinity DataKi: 1.29E+4nM ΔG°: -27.9kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
Affinity DataKi: 1.62E+4nM ΔG°: -27.3kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
Affinity DataKi: 1.81E+4nM ΔG°: -27.1kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
Affinity DataKi: 2.28E+4nM ΔG°: -26.5kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
Affinity DataKi: 2.56E+4nM ΔG°: -26.2kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
Affinity DataKi: 2.87E+4nM ΔG°: -25.9kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
Affinity DataKi: 3.23E+4nM ΔG°: -25.6kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
Affinity DataKi: 3.70E+4nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 5.45E+4nM ΔG°: -24.3kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
Affinity DataKi: 9.08E+4nM ΔG°: -23.1kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
Affinity DataKi: 1.00E+5nMAssay Description:Inhibition of rat recombinant LAR expressed in Escherichia coli assessed as inhibition constant using pNPP as substrate incubated for 5 mins by liqui...More data for this Ligand-Target Pair
Ligand Info
Affinity DataKi: 1.03E+5nM ΔG°: -22.8kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
Affinity DataKi: 1.20E+5nMAssay Description:Inhibition of human PTPalpha assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
Affinity DataKi: 1.80E+5nMAssay Description:Inhibition of PTPalpha (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 3.88E+5nM ΔG°: -19.5kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
Affinity DataKi: 4.50E+5nMAssay Description:Inhibition of LAR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 4.74E+5nM ΔG°: -19.0kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
Affinity DataKi: 5.48E+5nM ΔG°: -18.6kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
Affinity DataKi: 1.09E+6nM ΔG°: -16.9kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+6nMAssay Description:Inhibition of PTPalpha (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+6nMAssay Description:Inhibition of LAR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 3.60E+6nMAssay Description:Inhibition of human recombinant VHR expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using pNPP as substrate by stopped-flow ...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant Aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Inhibition of ALR in Fischer-344 rat lens using D,L-glyceraldehyde as substrate in presence of NADPH measured after 3 mins by spectrophotometric assa...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibition of recombinant human DYKDDDD-tagged EGFR (669 to 1210 residues) expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrateMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 5nMAssay Description:Inhibition of human PTP1B (1 to 298 residues) expressed in Escherichia coli using FDP as substrate by microplate readerMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair