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Beta-1 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 0.0200nMMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

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BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 0.320nMAssay Description:Displacement of [3H]CGP12177 from human beta2 adrenoceptor expressed in CHO cell membranesMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

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BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 0.380nMMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway
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Beta-2 adrenergic receptor(Rattus norvegicus)
Niigata College of Pharmacy

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 0.460nMMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 0.460nMAssay Description:Displacement of [3H]-CGP-12177 from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

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BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 0.610nMMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Rattus norvegicus (Rat))
Niigata College of Pharmacy

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 0.690nMMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 0.790nMMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 0.800nMMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 0.830nMMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 1.40nMAssay Description:Displacement of [3H]CGP12177 from human beta1 adrenoceptor expressed in HEK293T cell membranesMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 1.70nMAssay Description:Displacement of [3H]-CGP12177 from human beta2 ADR expressed in HEK293T cell membrane after 90 mins by scintillation countingMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 1.80nMMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 2.10nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Beta-1 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 2.30nMAssay Description:Inhibition of [3H]-Dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes.More data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
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Beta-1/Beta-2/Beta-3 adrenergic receptor(Rattus norvegicus (Rat))
Virginia Commonwealth University

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 2.40nMAssay Description:Inhibitory activity against beta adrenergic receptor of rat frontal cortex homogenate using (1.0 nM) [3H]- dihydroalprenololMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
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Beta-1 adrenergic receptor(Mus musculus)
Friedrich-Alexander Universit£T Erlangen-N£Rnberg

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 2.40nMAssay Description:Displacement of [3H]CGP12177 from mouse beta1 adrenoceptor expressed in HEK293T cell membranesMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Beta-1 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 2.69nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Beta-1 adrenergic receptor(Rattus norvegicus (Rat))
Niigata College of Pharmacy

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 3nMAssay Description:Radioligand receptor binding studies were conducted in the rat brain.More data for this Ligand-Target Pair

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Details Article

Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 3.70nMAssay Description:Displacement of [3H]-(R,R')-methoxyfenoterol from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
University of Alberta

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 5.01nMMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 5.24nMMore data for this Ligand-Target Pair

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PDB Reactome pathway
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Beta-1/Beta-2/Beta-3 adrenergic receptor(Rattus norvegicus (Rat))
Virginia Commonwealth University

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 6.5nMAssay Description:Evaluated for beta-receptor affinity determined in rat brain membrane fraction with [3H]- dihydroalprenololMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Beta-1 adrenergic receptor(Rattus norvegicus (Rat))
Niigata College of Pharmacy

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 7nMAssay Description:Displacement of [3H]CGP-12177 from beta1 adrenergic receptor in rat brain cerebral cortex after 60 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Beta-1 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 12nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 ADR expressed in HEK293T cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Beta-1 adrenergic receptor(Rattus norvegicus (Rat))
Niigata College of Pharmacy

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 15nMAssay Description:Displacement of [3H]-CGP-12177 from beta1-adrenergic receptor in rat brain cortex after 1 hr by Microbeta scintillation counting methodMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
University of Alberta

Curated by PDSP K_i Database

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

Ki: 17nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
University of Alberta

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 30.9nMMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1A/1B/1D/2C(Homo sapiens (Human))
University of Heidelberg

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 31nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
University of Alberta

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 39nMMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway
UniProtKB/SwissProt
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Beta-2 adrenergic receptor(Rattus norvegicus)
Niigata College of Pharmacy

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 43.6nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
University of Alberta

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 50nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.More data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
University of Alberta

Curated by PDSP K_i Database

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

Ki: 50nMAssay Description:Binding affinity (Ki) to rat cortical membranes at 5-HT1B binding site by using [125 I] ICYP as a radioligand.More data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

Ki: 55nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.More data for this Ligand-Target Pair

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PDB Reactome pathway
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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sorbonne University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 55nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
University of Alberta

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 56.2nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
University of Alberta

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 57.5nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
University of Alberta

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 77.6nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(RABBIT)
University of Montana

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 78nMMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Rattus norvegicus (Rat))
Niigata College of Pharmacy

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 81.3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 90nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.More data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 113nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor by the displacement of [125I]trans-8-OH-PIPAT in membrane homogenates of hippocampal tissue ...More data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

Ki: 115nMAssay Description:Evaluated for the binding affinity to hippocampus striatal membranes at 5-hydroxytryptamine 1A receptor binding site by using [3H]-8-OH- DPAT as a ra...More data for this Ligand-Target Pair

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Beta-3 adrenergic receptor(Homo sapiens (Human))
UniversitÄT WÜRzburg

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 186nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sorbonne University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 272nMMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway
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5-hydroxytryptamine receptor 1A/1B/1D/1F(RAT)
TBA

Curated by ChEMBL

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

Ki: 300nMAssay Description:Evaluated for binding affinity towards rat cortical membranes at 5-hydroxytryptamine 1 receptor binding site by using [3H]-5-HT as a radioligand.More data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 400nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
University of Alberta

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 631nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
University of Alberta

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 640nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Sri International

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 1.05E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Vanderbilt University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 1.20E+3nMMore data for this Ligand-Target Pair

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Alpha-2C adrenergic receptor(RAT)
University of California

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 1.30E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

Ki: 1.40E+3nMAssay Description:Evaluated for the binding affinity to porcine choroid plexus at 5-hydroxytryptamine 2C receptor binding site by using [3H]-MES as a radioligand.More data for this Ligand-Target Pair

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Beta-1/Beta-2/Beta-3 adrenergic receptor(Rattus norvegicus (Rat))
Virginia Commonwealth University

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 1.60E+3nMAssay Description:Inhibition constant from beta adrenergic receptor binding assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL

BDBM36108((R)-propranolol)

Ki: 1.70E+3nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Voltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Marion Merrell Dow

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 2.00E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Vanderbilt University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 2.46E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
University of Alberta

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 2.69E+3nMMore data for this Ligand-Target Pair

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Alpha-2C adrenergic receptor(RAT)
University of California

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 2.79E+3nMMore data for this Ligand-Target Pair

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D(2) dopamine receptor(BOVINE)
TBA

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 2.80E+3nMMore data for this Ligand-Target Pair

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Serotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

Ki: 3.50E+3nMAssay Description:Binding affinity to 5-hydroxytryptamine 2 receptor in rat frontal cortical membranes by [3H]- KET displacement.More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 3.70E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
University of Alberta

Curated by PDSP K_i Database

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

Ki: 4.10E+3nMAssay Description:Agonist activity to the human recombinant 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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D(3) dopamine receptor(Rattus norvegicus (Rat))
University Of Pennsylvania

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: >5.00E+3nMAssay Description:Tested for binding affinity against dopamine receptor D3 expressed in Sf9 cells.More data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
TBA

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 5.00E+3nMMore data for this Ligand-Target Pair

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Serotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

Ki: 5.90E+3nMAssay Description:Binding affinity to rat cortical membranes at 5-hydroxytryptamine 2 (5-HT2) receptor using [3H]KET as a radioligandMore data for this Ligand-Target Pair

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Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 5.90E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 5B(MOUSE)
Cnrs

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 6.31E+3nMMore data for this Ligand-Target Pair

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Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 6.90E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
TBA

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 7.00E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
University of Alberta

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 7.08E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Sri International

Curated by PDSP K_i Database

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

Ki: 8.10E+3nMAssay Description:Displacement of [3H]ketanserin from rat 5HT2A receptor expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Rattus norvegicus (Rat))
Niigata College of Pharmacy

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 9.70E+3nMAssay Description:Displacement of [3H]CGP12177 from beta1 adrenergic receptor in rat cerebral cortex by liquid scintillation countingMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 5A(MOUSE)
Cnrs

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Histamine H1 receptor(Homo sapiens (Human))
Mayo Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Voltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Marion Merrell Dow

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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D(1A) dopamine receptor(BOVINE)
University of Nebraska

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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D(1A) dopamine receptor(BOVINE)
University of Nebraska

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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D(2) dopamine receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: >1.00E+4nMAssay Description:Competitive binding assay against Dopamine receptor D2 in rat striatal membranes and [125I]-IBF radioligandMore data for this Ligand-Target Pair

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D(2) dopamine receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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D(2) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
University of Alberta

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
University of Alberta

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 6(MOUSE)
Cnrs

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 5A(MOUSE)
Cnrs

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
University of Alberta

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: >1.00E+4nMAssay Description:Agonist activity to the human recombinant 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Rattus norvegicus)
Niigata College of Pharmacy

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 3A(Mus musculus (house mouse))
Sri International

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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D(1A) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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D(2) dopamine receptor(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 1.29E+4nMAssay Description:Inhibitory constant against binding of [125I]- IBZM to D2 receptor in rat striatal membraneMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
Universit£

Curated by ChEMBL

BDBM60973((2R)-1-(1-naphthalenyloxy)-3-(propan-2-ylamino)-2-...)

Ki: 1.45E+4nMAssay Description:Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytesMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

ATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Ki: 4.80E+4nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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ATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences

Curated by ChEMBL

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

Ki: 1.70E+5nMAssay Description:Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...More data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 0.480nMAssay Description:Antagonist activity at ADRB2 endogenously expressed in HEK293 cells transfected with cAMP FRET biosensor assessed as inhibition of cimaterol-induced ...More data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 0.550nMAssay Description:Antagonist activity at ADRB2 endogenously expressed in HEK293 cells transfected with cAMP FRET biosensor assessed as inhibition of cimaterol-induced ...More data for this Ligand-Target Pair

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Beta-1/Beta-2/Beta-3 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 4nMAssay Description:Concentration effective against displacing [3H]dihydroalprenolol from beta adrenergic receptor from canine ventricular tissueMore data for this Ligand-Target Pair

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Beta-1/Beta-2/Beta-3 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 12nMAssay Description:Tested for Beta Adrenergic receptor binding inhibition from canine ventricular tissue, using [3H]dihydroalprenolol as the radioligand in anesthetized...More data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Canis familiaris)
Berlex Laboratories

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 17nMAssay Description:Tested for Beta-2 adrenergic receptor selectivity in canine lung tissue in anesthetized dogsMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 18nMAssay Description:Tested for Beta-1 adrenergic receptor selectivity in canine cardiac tissue in anesthetized dogsMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 29nMAssay Description:Inhibitory activity against beta-2 adrenergic receptor in guinea pig tracheal strip is determinedMore data for this Ligand-Target Pair

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Beta-1/Beta-2/Beta-3 adrenergic receptor(Rattus norvegicus (Rat))
Virginia Commonwealth University

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 30nMAssay Description:Inhibition of Rap1A-mediated geranylgeranylation expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 35nMAssay Description:Inhibitory activity against beta-1 adrenergic receptor in guinea pig atria is determinedMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 50nMAssay Description:Antagonist activity at human beta2 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL

BDBM36108((R)-propranolol)

IC50: 170nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat frontal cortex using [3H]8-OH-DPAT as a radioligandMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Beta-1 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 251nMAssay Description:Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assayMore data for this Ligand-Target Pair

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Cytochrome P450 2D26(Rattus norvegicus)
Vrije Universiteit

Curated by ChEMBL

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

IC50: 350nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair

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Cytochrome P450 2D26(Rattus norvegicus)
Vrije Universiteit

Curated by ChEMBL

BDBM36108((R)-propranolol)

IC50: 420nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
University of Alberta

Curated by PDSP K_i Database

BDBM36108((R)-propranolol)

IC50: 490nMAssay Description:Binding affinity against 5-HT1B receptor in rat frontal cortex using [3H]-5-HT in presence of 0.1 uM [3H]-8-OH-DPAT as a radioligandMore data for this Ligand-Target Pair

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Cytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

IC50: 1.40E+3nMAssay Description:Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell lineMore data for this Ligand-Target Pair

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Cytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 1.90E+3nMAssay Description:Inhibitory activity against recombinant human Cytochrome P450 2D6 (CYP2D6) after incubated for 45 minutesMore data for this Ligand-Target Pair

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Cytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL

BDBM36108((R)-propranolol)

IC50: 1.90E+3nMAssay Description:Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell lineMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 2.10E+3nMAssay Description:Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNAMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 2.83E+3nMAssay Description:Inhibition of hERG K channelMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sorbonne University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 3.98E+3nMAssay Description:Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human 5-HT2A receptor expressed in CHO-K1 cells assessed as seretonin-induced calcium level by FDSS assayMore data for this Ligand-Target Pair

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Endothelin-1 receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type ETA receptor expressed in CHO-K1 cells assessed as endothelin-1-induced calcium by HTRF assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type 5-HT7 receptor expressed in HEK cells assessed as seretonin-induced cAMP by HTRF assayMore data for this Ligand-Target Pair

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Mu-type opioid receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type opioid-mu receptor expressed in CHO-K1 cells assessed as DAMGO-induced cAMP by HTRF assayMore data for this Ligand-Target Pair

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Kappa-type opioid receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type opioid-kappa 1 receptor expressed in CHO-K1 cells assessed as U50488-induced cAMP by HTRF assayMore data for this Ligand-Target Pair

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D(1A) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type D1 receptor expressed in CHO cells assessed as dopamine-induced cAMP by HTRF assayMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M2(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type M2 receptor expressed in CHO-K1 cells assessed as acetylcholine-induced cAMP by HTRF assayMore data for this Ligand-Target Pair

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Cholecystokinin receptor type A(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type CCKA receptor expressed in CHO-K1 cells assessed as CCK8-induced calcium by FDSS assayMore data for this Ligand-Target Pair

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Alpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type alpha 2C receptor expressed in CHO-K1 cells assessed as epinephrine-induced cAMP by HTRF assayMore data for this Ligand-Target Pair

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Alpha-1A adrenergic receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type alpha 1A receptor expressed in CHO cells assessed as EP-induced calcium by HTRF assayMore data for this Ligand-Target Pair

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Adenosine receptor A3(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type A3 receptor expressed in CHO-K1 cells assessed as IB MECA-induced cAMP by HTRF assayMore data for this Ligand-Target Pair

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Cytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 5.01E+3nMAssay Description:Inhibition of human CYP2D6 by LC-MS analysisMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human 5-HT2B receptor expressed in CHO-K1 cells assessed as seretonin-induced calcium level by FDSS assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
University of Alberta

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human 5-HT1B receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assayMore data for this Ligand-Target Pair

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Adenosine receptor A2a(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type A2A receptor expressed in CHO-K1 cells assessed as NECA-induced cAMP by HTRF assayMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M3(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type M3 receptor expressed in CHO-K1 cells assessed as acetylcholine-induced calcium by FDSS assayMore data for this Ligand-Target Pair

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Delta-type opioid receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type opioid-delta 1 receptor expressed in CHO-K1 cells assessed as DPDPE-induced cAMP by HTRF assayMore data for this Ligand-Target Pair

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Alpha-2A adrenergic receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type alpha 2A receptor expressed in CHO-K1 cells assessed as epinephrine-induced cAMP by HTRF assayMore data for this Ligand-Target Pair

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D(2) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type D2 receptor expressed in CHO-K1 cells assessed as dopamine-induced cAMP by HTRF assayMore data for this Ligand-Target Pair

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Vasopressin V1a receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type AVPR1A receptor expressed in CHO-K1 cells assessed as vassopressin-induced calcium by FDSS assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human 5-HT6 receptor expressed in 1321N1 cells assessed as seretonin-induced cAMP by HTRF assayMore data for this Ligand-Target Pair

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Type-1 angiotensin II receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type AGTR1 receptor expressed in CHO-K1 cells assessed as angiotensin-2-induced calcium by FDSS assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human 5-HT2C receptor expressed in CHO-K1 cells assessed as seretonin-induced calcium level by FDSS assayMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M1(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <5.01E+3nMAssay Description:Antagonist activity at human wild-type M1 receptor expressed in CHO-K1 cells assessed as acetylcholine-induced calcium by FDSS assayMore data for this Ligand-Target Pair

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Sodium/bile acid cotransporter(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 5.50E+3nMAssay Description:TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cellsMore data for this Ligand-Target Pair

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Sodium/bile acid cotransporter(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

IC50: 6.10E+3nMAssay Description:TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cellsMore data for this Ligand-Target Pair

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Serotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL

BDBM36108((R)-propranolol)

IC50: 7.94E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor in rat frontal cortex using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair

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Cytochrome P450 2C9(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <1.00E+4nMAssay Description:Inhibition of human CYP2C9 by LC-MS analysisMore data for this Ligand-Target Pair

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Sodium channel protein type 1/2/3 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM60973((2R)-1-(1-naphthalenyloxy)-3-(propan-2-ylamino)-2-...)

IC50: 1.00E+4nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair

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Cytochrome P450 2C19(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <1.00E+4nMAssay Description:Inhibition of human CYP2C19 by LC-MS analysisMore data for this Ligand-Target Pair

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Cytochrome P450 2C8(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <1.00E+4nMAssay Description:Inhibition of human CYP2C8 by LC-MS analysisMore data for this Ligand-Target Pair

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Cytochrome P450 3A4(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <1.00E+4nMAssay Description:Inhibition of human CYP3A4 by LC-MS analysisMore data for this Ligand-Target Pair

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Cytochrome P450 1A2(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: <1.00E+4nMAssay Description:Inhibition of human CYP1A2 by LC-MS analysisMore data for this Ligand-Target Pair

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Sodium channel protein type 1/2/3 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

IC50: 1.30E+4nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1C(Cavia porcellus)
Jagiellonian University

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 1.80E+4nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1C(Cavia porcellus)
Jagiellonian University

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 1.80E+4nMAssay Description:Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytesMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 2.10E+4nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair

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Cytochrome P450 2J2(Homo sapiens (Human))
Tongji University

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: >5.00E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair

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Solute carrier family 22 member 1(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 6.32E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair

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Cytochrome P450 2D4(Rattus norvegicus)
Vrije Universiteit

Curated by ChEMBL

BDBM36108((R)-propranolol)

IC50: 1.17E+5nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D4 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair

Cytochrome P450 2D4(Rattus norvegicus)
Vrije Universiteit

Curated by ChEMBL

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

IC50: 1.33E+5nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D4 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair

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Bile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair

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ATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair

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ATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair

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ATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair

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Bile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair

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Cytochrome P450 2D3(Rattus norvegicus)
Vrije Universiteit

Curated by ChEMBL

BDBM36108((R)-propranolol)

IC50: 1.55E+5nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D3 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Cytochrome P450 2D3(Rattus norvegicus)
Vrije Universiteit

Curated by ChEMBL

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

IC50: 1.72E+5nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D3 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Cytochrome P450 2D1(Rattus norvegicus)
Vrije Universiteit

Curated by ChEMBL

BDBM36108((R)-propranolol)

IC50: 1.82E+5nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D1 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
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Cytochrome P450 2D1(Rattus norvegicus)
Vrije Universiteit

Curated by ChEMBL

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

IC50: 5.71E+5nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D1 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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ATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: 5.73E+5nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair

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ATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences

Curated by ChEMBL

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

IC50: 5.74E+5nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair

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ATP-dependent translocase ABCB1(Homo sapiens (Human))
Bulgarian Academy Of Sciences

Curated by ChEMBL

BDBM36108((R)-propranolol)

IC50: 5.83E+5nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Bile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair

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Bile salt export pump(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: >1.00E+6nMAssay Description:Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...More data for this Ligand-Target Pair

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Bile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

IC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptakeMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 6.90nMpH: 7.4 T: 2°CAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 0.830nMAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair

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Beta-3 adrenergic receptor(Homo sapiens (Human))
UniversitÄT WÜRzburg

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 117nMAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 2.40nMAssay Description:Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 8.70nMAssay Description:Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 2nMAssay Description:Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparationMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 1.70nMAssay Description:In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea p...More data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 2.40nMAssay Description:Beta-1 adrenergic receptor blocking activity in atria of guinea pig.More data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 3.10nMAssay Description:Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)More data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 7.90nMAssay Description:Binding affinity to human adrenergic beta2 receptorMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 0.240nMAssay Description:Antagonist activity at human beta-2 adrenergic receptor expressed in salbutamol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence co...More data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 0.603nMAssay Description:Displacement of [3H]-CGP 12177 from human beta-2 adrenergic receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 1.80nMAssay Description:Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluoresce...More data for this Ligand-Target Pair

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Beta-3 adrenergic receptor(Homo sapiens (Human))
UniversitÄT WÜRzburg

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 214nMAssay Description:Displacement of [3H]-CGP 12177 from human beta-3 adrenergic receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 6nMAssay Description:Displacement of [3H]-CGP 12177 from human beta-1 adrenergic receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(BOVINE)
TBA

Curated by ChEMBL

BDBM60973((2R)-1-(1-naphthalenyloxy)-3-(propan-2-ylamino)-2-...)

Kd: 0.891nMAssay Description:Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Beta-3 adrenergic receptor(Homo sapiens (Human))
UniversitÄT WÜRzburg

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 162nMAssay Description:Antagonist activity at human beta-3 adrenergic receptor expressed in fenoterol-stimulated CHOK1 cells assessed as CRE-SPAP level by fluorescence corr...More data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 200nMAssay Description:Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluoresce...More data for this Ligand-Target Pair

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Albumin(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 4.37E+5nMAssay Description:Binding affinity to human serum albumin by PAMPA methodMore data for this Ligand-Target Pair

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Albumin(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 3.55E+5nMAssay Description:Binding affinity to 50 uM human serum albumin at 10 uM by PAMPA methodMore data for this Ligand-Target Pair

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Albumin(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 6.61E+5nMAssay Description:Binding affinity to 100 uM human serum albumin at 10 uM by PAMPA methodMore data for this Ligand-Target Pair

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Albumin(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 6.03E+5nMAssay Description:Binding affinity to 300 uM human serum albumin at 10 uM by PAMPA methodMore data for this Ligand-Target Pair

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Albumin(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 4.37E+5nMAssay Description:Binding affinity to 100 uM human serum albumin at 50 uM by PAMPA methodMore data for this Ligand-Target Pair

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Albumin(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 6.31E+5nMAssay Description:Binding affinity to 600 uM human serum albumin at 10 uM by PAMPA methodMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

EC50: 1.80nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant adrenergic beta-1 receptor expressed in Rex16 cellsMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 3.39nMAssay Description:The apparent pA2 value was measured for beta-2 adrenergic blocking activity on the trachea of guinea pigMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 43.6nMAssay Description:Antagonist activity of compound against Beta-2 adrenergic receptor in isolated guinea pig tracheaMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 1.26nMAssay Description:Ability to block Beta-2 adrenergic receptor in guinea pig trachea preparationMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 3.02nMAssay Description:In vitro beta-2 adrenergic receptor activity was determined by measuring inhibition of the isoproterenol induced relaxation in isolated guinea pig tr...More data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 3.39nMAssay Description:Beta-2 adrenergic receptor blocking activity in trachea of guinea pig.More data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Canis familiaris)
Berlex Laboratories

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 1.78nMAssay Description:Compound was evaluated for competitive antagonism of beta-2 adrenergic receptor in rat uterus measured as pA2 (-log KB)More data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(BOVINE)
TBA

Curated by ChEMBL

BDBM60973((2R)-1-(1-naphthalenyloxy)-3-(propan-2-ylamino)-2-...)

Kd: 0.890nMAssay Description:Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Beta-1/Beta-2/Beta-3 adrenergic receptor(Rattus norvegicus (Rat))
Virginia Commonwealth University

Curated by ChEMBL

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

Kd: 0.700nMAssay Description:Binding affinity against Beta adrenergic receptor in C6-2B astrocytoma cells, using [125I]-iodohydroxybenzylpindolol-benzylpindolol([125I]-HYP)More data for this Ligand-Target Pair

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Adenosine receptor A2a(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type A2A receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human 5-HT6 receptor expressed in 1321N1 cells assessed as cAMP by HTRF assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
University of Alberta

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human 5-HT1B receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M2(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type M2 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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Delta-type opioid receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type opioid-delta 1 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human 5-HT2B receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair

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Type-1 angiotensin II receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type AGTR1 receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M1(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type M1 receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type 5-HT7 receptor expressed in HEK cells assessed as cAMP by HTRF assayMore data for this Ligand-Target Pair

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Adenosine receptor A3(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type A3 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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Alpha-1A adrenergic receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type alpha 1A receptor expressed in CHO cells assessed as calcium level by HTRF assayMore data for this Ligand-Target Pair

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Alpha-2A adrenergic receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type alpha 2A receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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Alpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type alpha 2C receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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Vasopressin V1a receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type AVPR1A receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair

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Cholecystokinin receptor type A(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type CCKA receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M3(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type M3 receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair

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Endothelin-1 receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type ETA receptor expressed in CHO-K1 cells assessed as calcium level by HTRF assayMore data for this Ligand-Target Pair

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Kappa-type opioid receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type opioid-kappa 1 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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D(2) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type D2 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human 5-HT2C receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assayMore data for this Ligand-Target Pair

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Mu-type opioid receptor(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type opioid-mu receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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D(1A) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: <5.01E+3nMAssay Description:Agonist activity at human wild-type D1 receptor expressed in CHO cells assessed as cAMP level by HTRF assayMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 0.100nMAssay Description:Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 150nMAssay Description:Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes assessed as intrinsic Kd by liquid scintilla...More data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

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Nuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: 3.20E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair

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Nuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL

BDBM60973((2R)-1-(1-naphthalenyloxy)-3-(propan-2-ylamino)-2-...)

EC50: 4.00E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Nuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL

BDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)

EC50: 7.20E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair

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Nuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: 3.20E+4nMAssay Description:Agonist activity at full length TLX activating element expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as dec...More data for this Ligand-Target Pair

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Nuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

EC50: 3.70E+4nMAssay Description:Agonist activity at TAE expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as renilla luciferase reporter activi...More data for this Ligand-Target Pair

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Nuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL

BDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)

Kd: 500nMAssay Description:Binding affinity to TLX LBD expressed in His6-tagged Escherichia coli Rosetta assessed as binding constant measured after 300 sec at 200 mM by isothe...More data for this Ligand-Target Pair

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