Compile Data Set for Download or QSAR
maximum 50k data
Found 549 with Last Name = 'srivastava' and Initial = 'r'
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Indian Institute Of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50507554(CHEMBL4456911)
Affinity DataKi:  190nMAssay Description:Inhibition of Electric eel AChE using acetylthiocholine iodide as substrate after 10 mins measured for every mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Indian Institute Of Technology (Banaras Hindu University)

LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataKi:  490nMAssay Description:The enzyme kinetics were determined, wherein the arachidonic acid substrate either in the absence or presence of selected derivatives were evaluated ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Indian Institute Of Technology (Banaras Hindu University)

LigandPNGBDBM198173(2-((5-(4-Nitrophenylamino)-1,3,4-oxadiazol-2-yl)me...)
Affinity DataKi:  500nMAssay Description:The enzyme kinetics were determined, wherein the arachidonic acid substrate either in the absence or presence of selected derivatives were evaluated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Indian Institute Of Technology (Banaras Hindu University)

LigandPNGBDBM198172(2-((5-(4-Chlorophenylamino)-1,3,4-oxadiazol-2-yl)m...)
Affinity DataKi:  630nMAssay Description:The enzyme kinetics were determined, wherein the arachidonic acid substrate either in the absence or presence of selected derivatives were evaluated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Indian Institute Of Technology (Banaras Hindu University)

LigandPNGBDBM198171(2-((5-(4-Methoxyphenylamino)-1,3,4-oxadiazol-2-yl)...)
Affinity DataKi:  650nMAssay Description:The enzyme kinetics were determined, wherein the arachidonic acid substrate either in the absence or presence of selected derivatives were evaluated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Indian Institute Of Technology (Banaras Hindu University)

LigandPNGBDBM198174(2-((5-(4-Methoxyphenylamino)-1,3,4-thiadiazol-2-yl...)
Affinity DataKi:  770nMAssay Description:The enzyme kinetics were determined, wherein the arachidonic acid substrate either in the absence or presence of selected derivatives were evaluated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Indian Institute Of Technology (Banaras Hindu University)

LigandPNGBDBM198176(2-((5-(4-Nitrophenylamino)-1,3,4-thiadiazol-2-yl)m...)
Affinity DataKi:  880nMAssay Description:The enzyme kinetics were determined, wherein the arachidonic acid substrate either in the absence or presence of selected derivatives were evaluated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Indian Institute Of Technology (Banaras Hindu University)

LigandPNGBDBM198175(2-((5-(4-Chlorophenylamino)-1,3,4-thiadiazol-2-yl)...)
Affinity DataKi:  960nMAssay Description:The enzyme kinetics were determined, wherein the arachidonic acid substrate either in the absence or presence of selected derivatives were evaluated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Indian Institute Of Technology (Banaras Hindu University)

LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  9.86E+3nMAssay Description:Competitive inhibition of ovine COX2 using arachidonic acid substrate by Ellman's spectrophotometric assay based Lineweaver-Burk double reciprocal pl...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Indian Institute Of Technology (Banaras Hindu University)

LigandPNGBDBM50114413(CHEMBL3608346)
Affinity DataKi:  1.45E+4nMAssay Description:Competitive inhibition of ovine COX2 using arachidonic acid substrate by Ellman's spectrophotometric assay based Lineweaver-Burk double reciprocal pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Indian Institute Of Technology (Banaras Hindu University)

LigandPNGBDBM50114414(CHEMBL3608347)
Affinity DataKi:  1.46E+4nMAssay Description:Competitive inhibition of ovine COX2 using arachidonic acid substrate by Ellman's spectrophotometric assay based Lineweaver-Burk double reciprocal pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Indian Institute Of Technology (Banaras Hindu University)

LigandPNGBDBM50114415(CHEMBL3608348)
Affinity DataKi:  1.47E+4nMAssay Description:Competitive inhibition of ovine COX2 using arachidonic acid substrate by Ellman's spectrophotometric assay based Lineweaver-Burk double reciprocal pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Indian Institute Of Technology (Banaras Hindu University)

LigandPNGBDBM50114416(CHEMBL3608351)
Affinity DataKi:  1.48E+4nMAssay Description:Competitive inhibition of ovine COX2 using arachidonic acid substrate by Ellman's spectrophotometric assay based Lineweaver-Burk double reciprocal pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Indian Institute Of Technology (Banaras Hindu University)

LigandPNGBDBM50114417(CHEMBL3608353)
Affinity DataKi:  1.48E+4nMAssay Description:Competitive inhibition of ovine COX2 using arachidonic acid substrate by Ellman's spectrophotometric assay based Lineweaver-Burk double reciprocal pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50:  4.80nMAssay Description:Antagonist activity at TLR7 (unknown origin) in PBMC cells assessed as reduction of IL-6 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 8(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50:  5.10nMAssay Description:Antagonist activity at TLR8 in human whole blood cells assessed as inhibition of IL-6 production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50:  5.70nMAssay Description:Antagonist activity at TLR7 in human whole blood cells assessed as inhibition of gardiquimod induced IL-6 production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Rattus norvegicus)
Hospital Regional Universitario

Curated by ChEMBL
LigandPNGBDBM50604669(CHEMBL5208485)
Affinity DataIC50:  6.30nMAssay Description:Positive allosteric modulator activity at GLP-1R in rat INS1 beta-cells assessed potentiation of GLP-1(7-36)NH2 induced insulin secretion at 0.1 nM i...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataIC50:  9nMAssay Description:Displacement of biotinylated acetylated histone H4 peptide from human recombinant N-terminal GST-tagged BRD4 BD1 (49 to 170 residues) expressed in Es...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human TLR7 overexpressed in HEK-Blue cells assessed as inhibition of gardiquimod-induced NFkappaB and AP-1 activation preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at TLR7 in human pDC assessed as inhibition of inactivated flu-virus induced IFN-alpha production incubated for 24 hrs measured b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 8(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at human TLR8 overexpressed in HEK-Blue cells assessed as inhibition of R848-induced NFkappaB and AP-1 activation preincubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Csir-Central Drug Research Institute

LigandPNGBDBM11162((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Affinity DataIC50:  18nMAssay Description:DPP-IV inhibitory activity was determined by measuring the p-nitroaniline (pNA) released from the chromogenic substrate hydrolysis (H-Gly-Pro-pNA). T...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Indian Institute Of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  40nMAssay Description:Inhibition of Electric eel AChE using acetylthiocholine iodide as substrate after 10 mins measured for every mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50399434(CHEMBL2179387)
Affinity DataIC50:  41nMAssay Description:Displacement of biotinylated acetylated histone H4 peptide from human recombinant N-terminal GST-tagged BRD4 BD1 (49 to 170 residues) expressed in Es...More data for this Ligand-Target Pair
TargetToll-like receptor 7(Mus musculus)
Princ

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50:  43nMAssay Description:Antagonist activity at TLR7 in mouse whole blood cells assessed as inhibition of gardiquimod induced IL-6 production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543468(CHEMBL4637139)
Affinity DataIC50:  70nMAssay Description:Antagonist activity at human TLR7 overexpressed in HEK-Blue cells assessed as inhibition of gardiquimod-induced NFkappaB and AP-1 activation preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM28802(2-{[(5-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...)
Affinity DataIC50:  97nMAssay Description:Binding affinity to human GST-tagged PPAR-alpha LBD expressed in Escherichia coli BL21 (DE3) PlysS after 30 mins in presence of fluorescein ligand FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM28802(2-{[(5-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...)
Affinity DataIC50:  97nM EC50:  4nMpH: 8.0 T: 2°CAssay Description:For hPPAR alpha, percentage inhibition was calculated relative to unlabeled GW2331, which was used as the active site-specific competitive binder. Fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543469(CHEMBL4637254)
Affinity DataIC50:  130nMAssay Description:Antagonist activity at human TLR7 overexpressed in HEK-Blue cells assessed as inhibition of gardiquimod-induced NFkappaB and AP-1 activation preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50314811(2-((4-(2-(2-(4-chlorophenyl)-5-methyloxazol-4-yl)e...)
Affinity DataIC50:  141nMAssay Description:Binding affinity to human His-tagged PPARgamma LBD (Q203-Y477) expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50314813(2-((3-(2-(2-(4-chlorophenyl)-5-methyloxazol-4-yl)e...)
Affinity DataIC50:  162nMAssay Description:Binding affinity to human His-tagged PPARgamma LBD (Q203-Y477) expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50600176(CHEMBL5183863)
Affinity DataIC50:  170nMAssay Description:Displacement of biotinylated acetylated histone H4 peptide from human recombinant N-terminal GST-tagged BRD4 BD1 (49 to 170 residues) expressed in Es...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543475(CHEMBL4649357)
Affinity DataIC50:  190nMAssay Description:Antagonist activity at human TLR9 overexpressed in HEK-Blue cells assessed as inhibition of ODN2006-induced NFkappaB and AP-1 activation preincubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50:  210nMAssay Description:Antagonist activity at TLR9 in human pDC assessed as inhibition of ODN2216-induced IFN-alpha production incubated for 24 hrs measured by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543479(CHEMBL4639038)
Affinity DataIC50:  216nMAssay Description:Antagonist activity at human TLR9 overexpressed in HEK-Blue cells assessed as inhibition of ODN2006-induced NFkappaB and AP-1 activation preincubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50399434(CHEMBL2179387)
Affinity DataIC50:  220nMAssay Description:Displacement of acetylated histone H4 peptide from His-tagged recombinant human BRD4 expressed in bacteria by AlphaScreen assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50600183(CHEMBL5180188)
Affinity DataIC50:  220nMAssay Description:Displacement of biotinylated acetylated histone H4 peptide from human recombinant N-terminal GST-tagged BRD4 BD1 (49 to 170 residues) expressed in Es...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50314832(2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)met...)
Affinity DataIC50:  228nMAssay Description:Binding affinity to human His-tagged PPARalpha LBD (E196-Y468) expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50314812(2-((4-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)met...)
Affinity DataIC50:  248nMAssay Description:Binding affinity to human His-tagged PPARgamma LBD (Q203-Y477) expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543466(CHEMBL4647818)
Affinity DataIC50:  250nMAssay Description:Antagonist activity at human TLR7 overexpressed in HEK-Blue cells assessed as inhibition of gardiquimod-induced NFkappaB and AP-1 activation preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM28800(2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...)
Affinity DataIC50:  260nMAssay Description:Binding affinity to human His-tagged PPARalpha LBD (E196-Y468) expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM28800(2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...)
Affinity DataIC50:  260nM EC50:  10nMpH: 8.0 T: 2°CAssay Description:For hPPAR alpha, percentage inhibition was calculated relative to unlabeled GW2331, which was used as the active site-specific competitive binder. Fl...More data for this Ligand-Target Pair
TargetToll-like receptor 9(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543470(CHEMBL4634741)
Affinity DataIC50:  260nMAssay Description:Antagonist activity at human TLR9 overexpressed in HEK-Blue cells assessed as inhibition of ODN2006-induced NFkappaB and AP-1 activation preincubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543487(CHEMBL4634302)
Affinity DataIC50:  270nMAssay Description:Antagonist activity at human TLR9 overexpressed in HEK-Blue cells assessed as inhibition of ODN2006-induced NFkappaB and AP-1 activation preincubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50:  320nMAssay Description:Antagonist activity at TLR9 in human whole blood cells assessed as inhibition of ODN-2216 induced IL-6 production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50600184(CHEMBL5182381)
Affinity DataIC50:  330nMAssay Description:Displacement of biotinylated acetylated histone H4 peptide from human recombinant N-terminal GST-tagged BRD4 BD1 (49 to 170 residues) expressed in Es...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50314834(2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)met...)
Affinity DataIC50:  336nMAssay Description:Binding affinity to human His-tagged PPARalpha LBD (E196-Y468) expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50314814(2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)met...)
Affinity DataIC50:  347nMAssay Description:Binding affinity to human His-tagged PPARalpha LBD (E196-Y468) expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50314833(2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)met...)
Affinity DataIC50:  351nMAssay Description:Binding affinity to human His-tagged PPARalpha LBD (E196-Y468) expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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