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Report error Found 116 of ic50 for UniProtKB: P18090
LigandPNGBDBM50497048(CHEMBL3246767)
Affinity DataIC50:  0.00130nMAssay Description:Inhibition of beta-adrenergic receptor in rat portal veinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50497052(CHEMBL3246792)
Affinity DataIC50:  0.0450nMAssay Description:Inhibition of beta-adrenergic receptor in rat portal veinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50497050(CHEMBL3244454)
Affinity DataIC50:  0.0510nMAssay Description:Inhibition of beta-adrenergic receptor in rat portal veinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50497051(CHEMBL3246789)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of beta-adrenergic receptor in rat portal veinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50497049(CHEMBL3246801)
Affinity DataIC50:  0.460nMAssay Description:Inhibition of beta-adrenergic receptor in rat portal veinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50497054(CHEMBL3246790)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of beta-adrenergic receptor in rat portal veinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50212981(CHEMBL543099 | SR-59062A)
Affinity DataIC50:  0.900nMAssay Description:Beta-adrenergic agonistic activity in rat proximal colon in presence of phentolamine (10 uM), desmethylimipramine (0.5 uM) and hydrocortisone (30 uM)More data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50212980(CHEMBL553039 | SR-58997A)
Affinity DataIC50:  1.10nMAssay Description:Beta-adrenergic agonistic activity in rat proximal colon in presence of phentolamine (10 uM), desmethylimipramine (0.5 uM) and hydrocortisone (30 uM)More data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50497053(CHEMBL3246795)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of beta-adrenergic receptor in rat portal veinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rat)
University of Urbino

Curated by ChEMBL
LigandPNGBDBM25753(2-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50226969(CHEMBL39915)
Affinity DataIC50:  3.10nMAssay Description:The compound was evaluated for the inhibition of [125I]cyanopindolol binding to beta adrenergic receptor in rat reticulocyte membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50212977(AMIBEGRON HYDROCHLORIDE | Amibegron HCl | SR-58611...)
Affinity DataIC50:  3.5nMAssay Description:Beta-adrenergic agonistic activity in rat proximal colon in presence of phentolamine (10 uM), desmethylimipramine (0.5 uM) and hydrocortisone (30 uM)More data for this Ligand-Target Pair
In DepthDetails
TargetBeta-1 adrenergic receptor(Rat)
University of Urbino

Curated by ChEMBL
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50:  5.30nMAssay Description:Compound was evaluated in vitro for beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50226968(CHEMBL287883)
Affinity DataIC50:  5.30nMAssay Description:The compound was evaluated for the inhibition of [125I]cyanopindolol binding to beta adrenergic receptor in rat reticulocyte membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50226971(CHEMBL41605)
Affinity DataIC50:  7.60nMAssay Description:The compound was evaluated for the inhibition of [125I]cyanopindolol binding to beta adrenergic receptor in rat reticulocyte membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50497047(CHEMBL3246800)
Affinity DataIC50: >8nMAssay Description:Inhibition of beta-adrenergic receptor in rat portal veinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50367137(CHEMBL1203891)
Affinity DataIC50:  19nMAssay Description:Effect on synaptosomal uptake inhibition of Noradrenaline (NA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50212979(CHEMBL543333)
Affinity DataIC50:  21nMAssay Description:Beta-adrenergic agonistic activity in rat proximal colonMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50226970(CHEMBL41255)
Affinity DataIC50:  22nMAssay Description:The compound was evaluated for the inhibition of [125I]cyanopindolol binding to beta adrenergic receptor in rat reticulocyte membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50367137(CHEMBL1203891)
Affinity DataIC50:  30nMAssay Description:Effect on synaptosomal uptake inhibition of Noradrenaline (NA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Rap1A-mediated geranylgeranylation expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
LigandPNGBDBM50020240(1-[6-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-4-meth...)
Affinity DataIC50:  32nMAssay Description:Effect on synaptosomal uptake inhibition of Noradrenaline (NA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50020240(1-[6-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-4-meth...)
Affinity DataIC50:  45nMAssay Description:Effect on synaptosomal uptake inhibition of Noradrenaline (NA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50212977(AMIBEGRON HYDROCHLORIDE | Amibegron HCl | SR-58611...)
Affinity DataIC50:  47nMAssay Description:Beta-adrenergic agonistic activity in rat proximal colonMore data for this Ligand-Target Pair
In DepthDetails
TargetBeta-1 adrenergic receptor(Rat)
University of Urbino

Curated by ChEMBL
LigandPNGBDBM50002132((4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethyl...)
Affinity DataIC50:  59nMAssay Description:Compound was evaluated for its binding affinity towards Beta-1 adrenergic receptor in rat heart membrane by displacing [125I]- iodocyanopindololMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50212978(CHEMBL541542)
Affinity DataIC50:  90nMAssay Description:Beta-adrenergic agonistic activity in rat proximal colonMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50020240(1-[6-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-4-meth...)
Affinity DataIC50:  97nMAssay Description:Effect on synaptosomal uptake inhibition of Noradrenaline (NA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50:  100nMAssay Description:Inhibition of H-Ras-mediated farnesylation expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rat)
University of Urbino

Curated by ChEMBL
LigandPNGBDBM50272481(CHEMBL4128940)
Affinity DataIC50:  106nMAssay Description:Displacement of [3H]-CGP-12177 from adrenergic beta1 receptor in Wistar rat cortex incubated for 60 mins by microbeta liquid scintillation counting a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50026951((cis) 2-{4-[6-Fluoro-3-(4-fluoro-phenyl)-indan-1-y...)
Affinity DataIC50:  140nMAssay Description:Effect on synaptosomal uptake inhibition of Noradrenaline (NA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50026951((cis) 2-{4-[6-Fluoro-3-(4-fluoro-phenyl)-indan-1-y...)
Affinity DataIC50:  150nMAssay Description:Effect on synaptosomal uptake inhibition of Noradrenaline (NA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rat)
University of Urbino

Curated by ChEMBL
LigandPNGBDBM50272471(CHEMBL4127540)
Affinity DataIC50:  179nMAssay Description:Displacement of [3H]-CGP-12177 from adrenergic beta1 receptor in Wistar rat cortex incubated for 60 mins by microbeta liquid scintillation counting a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rat)
University of Urbino

Curated by ChEMBL
LigandPNGBDBM50272483(CHEMBL4128794)
Affinity DataIC50:  179nMAssay Description:Displacement of [3H]-CGP-12177 from adrenergic beta1 receptor in Wistar rat cortex incubated for 60 mins by microbeta liquid scintillation counting a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50212978(CHEMBL541542)
Affinity DataIC50:  185nMAssay Description:Beta-adrenergic agonistic activity in rat uterus preincubated with phenoxybenzamine (12 uM) for 30 minMore data for this Ligand-Target Pair
In DepthDetails
TargetBeta-1 adrenergic receptor(Rat)
University of Urbino

Curated by ChEMBL
LigandPNGBDBM50002133((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Affinity DataIC50:  190nMAssay Description:Compound was evaluated in vitro for beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50212980(CHEMBL553039 | SR-58997A)
Affinity DataIC50:  319nMAssay Description:Beta-adrenergic agonistic activity in rat uterus preincubated with phenoxybenzamine (12 uM) for 30 minMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50:  325nMAssay Description:The compound was evaluated for the inhibition of [125I]cyanopindolol binding to beta adrenergic receptor in rat reticulocyte membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50212979(CHEMBL543333)
Affinity DataIC50:  350nMAssay Description:Beta-adrenergic agonistic activity in rat uterus preincubated with phenoxybenzamine (12 uM) for 30 minMore data for this Ligand-Target Pair
In DepthDetails
TargetBeta-1 adrenergic receptor(Rat)
University of Urbino

Curated by ChEMBL
LigandPNGBDBM50272482(CHEMBL4130151)
Affinity DataIC50:  426nMAssay Description:Displacement of [3H]-CGP-12177 from adrenergic beta1 receptor in Wistar rat cortex incubated for 60 mins by microbeta liquid scintillation counting a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50212981(CHEMBL543099 | SR-59062A)
Affinity DataIC50:  480nMAssay Description:Beta-adrenergic agonistic activity in rat uterus preincubated with phenoxybenzamine (12 uM) for 30 minMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM25756((2R,3R)-2,3-dihydroxysuccinic acid;1-(isopropylami...)
Affinity DataIC50:  500nMAssay Description:Tested for beta2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50224296(CHEMBL161974)
Affinity DataIC50:  500nMAssay Description:Inhibition of Rap1A-mediated geranylgeranylation expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rat)
University of Urbino

Curated by ChEMBL
LigandPNGBDBM50002132((4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethyl...)
Affinity DataIC50:  500nMAssay Description:Compound was evaluated in vitro for beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50224297(CHEMBL158865)
Affinity DataIC50:  600nMAssay Description:Inhibition of H-Ras-mediated farnesylation expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rat)
University of Urbino

Curated by ChEMBL
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50:  600nMAssay Description:Compound was evaluated for its binding affinity towards beta-1 adrenergic receptor in rat heart membrane by displacing [125I]- iodocyanopindololMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50002012((trans) 2-{4-[3-(4-Fluoro-phenyl)-6-trifluoromethy...)
Affinity DataIC50:  660nMAssay Description:Effect on synaptosomal uptake inhibition of Noradrenaline (NA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rat)
University of Urbino

Curated by ChEMBL
LigandPNGBDBM50272472(CHEMBL4128231)
Affinity DataIC50:  785nMAssay Description:Displacement of [3H]-CGP-12177 from adrenergic beta1 receptor in Wistar rat cortex incubated for 60 mins by microbeta liquid scintillation counting a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50045878(2-(5-Chloro-2-phenyl-1H-indol-3-yl)-N,N-dihexyl-ac...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [125I]pindolol from beta-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50045890(CHEMBL99069 | {2-[2-(4-Fluoro-phenyl)-1H-indol-3-y...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [125I]pindolol from beta-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7287(8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octad...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [125I]pindolol from beta-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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