Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50031702
TargetSodium-dependent serotonin transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM84745(DULOXETINE | LY-248686 | CAS_136434-34-9 | LY24868...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM35229(Desmethylimipramine | 3-(10,11-dihydro-5H-dibenzo[...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human NET transfected in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM84745(DULOXETINE | LY-248686 | CAS_136434-34-9 | LY24868...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human NET transfected in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM30130(Prozac | cid_62857 | Fluoxetin | CHEMBL41 | CHEMBL...)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 22.1nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317592((-)-R-1-(1-(3-chlorophenyl)-2-(4-methylpiperazin-1...)
Affinity DataIC50: 30nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243500(CHEMBL511525 | CHEMBL1099179 | (-)-1-[(1S)-1-(3-Ch...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human NET transfected in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243500(CHEMBL511525 | CHEMBL1099179 | (-)-1-[(1S)-1-(3-Ch...)
Affinity DataIC50: 56nMAssay Description:Inhibition of human NET transfected in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317589((+)-S-1-(1-(5-chlorothiophen-3-yl)-2-(4-methylpipe...)
Affinity DataIC50: 57nMAssay Description:Inhibition of human NET transfected in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317589((+)-S-1-(1-(5-chlorothiophen-3-yl)-2-(4-methylpipe...)
Affinity DataIC50: 95nMAssay Description:Inhibition of human NET transfected in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317595(1-(1-(5-chlorothiophen-3-yl)-2-(piperazin-1-yl)eth...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human NET transfected in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243500(CHEMBL511525 | CHEMBL1099179 | (-)-1-[(1S)-1-(3-Ch...)
Affinity DataIC50: 175nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317589((+)-S-1-(1-(5-chlorothiophen-3-yl)-2-(4-methylpipe...)
Affinity DataIC50: 212nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317593(1-(1-(2,5-dichlorothiophen-3-yl)-2-(piperazin-1-yl...)
Affinity DataIC50: 225nMAssay Description:Inhibition of human NET transfected in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243500(CHEMBL511525 | CHEMBL1099179 | (-)-1-[(1S)-1-(3-Ch...)
Affinity DataIC50: 247nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317596(1-(1-(benzo[b]thiophen-3-yl)-2-(piperazin-1-yl)eth...)
Affinity DataIC50: 255nMAssay Description:Inhibition of human NET transfected in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317589((+)-S-1-(1-(5-chlorothiophen-3-yl)-2-(4-methylpipe...)
Affinity DataIC50: 389nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 535nMAssay Description:Inhibition of human NET transfected in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317597(1-(1-(benzo[b]thiophen-2-yl)-2-(piperazin-1-yl)eth...)
Affinity DataIC50: 550nMAssay Description:Inhibition of human NET transfected in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317592((-)-R-1-(1-(3-chlorophenyl)-2-(4-methylpiperazin-1...)
Affinity DataIC50: 576nMAssay Description:Inhibition of human NET transfected in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317594(1-(1-(2-chlorothiophen-3-yl)-2-(piperazin-1-yl)eth...)
Affinity DataIC50: 720nMAssay Description:Inhibition of human NET transfected in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM84745(DULOXETINE | LY-248686 | CAS_136434-34-9 | LY24868...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243500(CHEMBL511525 | CHEMBL1099179 | (-)-1-[(1S)-1-(3-Ch...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317590((-)-R-1-(1-(5-chlorothiophen-3-yl)-2-(4-methylpipe...)
Affinity DataIC50: 6.00E+3nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50317590((-)-R-1-(1-(5-chlorothiophen-3-yl)-2-(4-methylpipe...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human NET transfected in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed