Compile Data Set for Download or QSAR
maximum 50k data
Found 318 Enz. Inhib. hit(s) with all data for entry = 10450
LigandPNGBDBM536252((2S)-1-((2S,4R)-2-(5-(4-Bromophenyl)-5-methyl-4,5-...)
Affinity DataIC50:  62.8nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536252((2S)-1-((2S,4R)-2-(5-(4-Bromophenyl)-5-methyl-4,5-...)
Affinity DataIC50:  67.8nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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LigandPNGBDBM536223((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-(4-(4-meth...)
Affinity DataIC50:  202nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536223((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-(4-(4-meth...)
Affinity DataIC50:  239nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536223((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-(4-(4-meth...)
Affinity DataIC50:  304nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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LigandPNGBDBM536223((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-(4-(4-meth...)
Affinity DataIC50:  418nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536284((5S)-2-((4R)-4-hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Affinity DataIC50:  418nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536198(US11242344, Example 104.4)
Affinity DataIC50:  422nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536277(US11242344, Example 1001.2 | US11242344, Example 1...)
Affinity DataIC50:  795nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536284((5S)-2-((4R)-4-hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Affinity DataIC50:  939nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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LigandPNGBDBM536276((5S)-2-((4R)-4-hydroxy-1-(3-methyl-2-(3-methyl-1,2...)
Affinity DataIC50:  1.62E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536276((5S)-2-((4R)-4-hydroxy-1-(3-methyl-2-(3-methyl-1,2...)
Affinity DataIC50:  1.90E+3nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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LigandPNGBDBM536254(US11242344, Example 113.4)
Affinity DataIC50:  2.28E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536254(US11242344, Example 113.4)
Affinity DataIC50:  2.92E+3nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536250((2R)-1-((2S,4R)-2-(5-(4-Bromophenyl)-5-methyl-4,5-...)
Affinity DataIC50:  2.94E+3nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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LigandPNGBDBM536210(US11242344, Example 106.2 | US11242344, Example 10...)
Affinity DataIC50:  2.96E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536268((5S)-2-((4R)-4-hydroxy-1-(2-(3-hydroxyisoxazol-5- ...)
Affinity DataIC50:  4.35E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536183(2-((2S)-1-((4R)-4-hydroxy-2-((S)-5-methyl-5-(4-(4-...)
Affinity DataIC50:  4.68E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536240(1-Cyano-N-((2S)-1-((4R)-4-hydroxy-2-((S)-5-methyl-...)
Affinity DataIC50:  4.97E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536240(1-Cyano-N-((2S)-1-((4R)-4-hydroxy-2-((S)-5-methyl-...)
Affinity DataIC50:  5.11E+3nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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LigandPNGBDBM536206(US11242344, Example 105.4)
Affinity DataIC50:  5.39E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536183(2-((2S)-1-((4R)-4-hydroxy-2-((S)-5-methyl-5-(4-(4-...)
Affinity DataIC50:  5.48E+3nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536259(1-((2S,4R)-2-(5,5-dimethyl-1-phenyl-4,5-dihydro-1H...)
Affinity DataIC50:  5.67E+3nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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LigandPNGBDBM536178(N-((2S)-1-((4R)-4-Hydroxy-2-(5-methyl-5-(4-(4-meth...)
Affinity DataIC50:  6.17E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536297(US11242344, Example 1004.4)
Affinity DataIC50:  6.25E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536291((5S)-2-((4R)-1-(2-(3-((6-(2-((4-((3-Ethynylphenyl)...)
Affinity DataIC50:  6.25E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536250((2R)-1-((2S,4R)-2-(5-(4-Bromophenyl)-5-methyl-4,5-...)
Affinity DataIC50:  6.30E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536190(US11242344, Example 103.4)
Affinity DataIC50:  6.73E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536259(1-((2S,4R)-2-(5,5-dimethyl-1-phenyl-4,5-dihydro-1H...)
Affinity DataIC50:  9.32E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536271(1-((2S,4R)-2-((R)-5-(2′-fluoro-[1,1′-b...)
Affinity DataIC50:  1.00E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536215((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-phenyl-4,5...)
Affinity DataIC50:  1.07E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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LigandPNGBDBM536226(US11242344, Example 108.2)
Affinity DataIC50:  1.10E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536231((2R)-1-((2S,4R)-2-(2,3-dihydro-4'H-spiro[indene-1,...)
Affinity DataIC50:  1.62E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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LigandPNGBDBM536179((5S)-2-((4R)-4-hydroxy-1-((S)-1-(methylsulfonyl)pi...)
Affinity DataIC50:  1.67E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536275(US11242344, Example 1001.1)
Affinity DataIC50:  1.69E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536215((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-phenyl-4,5...)
Affinity DataIC50:  1.73E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536231((2R)-1-((2S,4R)-2-(2,3-dihydro-4'H-spiro[indene-1,...)
Affinity DataIC50:  1.75E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536231((2R)-1-((2S,4R)-2-(2,3-dihydro-4'H-spiro[indene-1,...)
Affinity DataIC50:  1.76E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536239((2R)-1-((4R)-2-(3,4-dihydro-2H,4'H-spiro[naphthale...)
Affinity DataIC50:  1.96E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536239((2R)-1-((4R)-2-(3,4-dihydro-2H,4'H-spiro[naphthale...)
Affinity DataIC50:  1.99E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536239((2R)-1-((4R)-2-(3,4-dihydro-2H,4'H-spiro[naphthale...)
Affinity DataIC50:  2.00E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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LigandPNGBDBM536232((5S)-2-((4R)-4-Hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Affinity DataIC50:  2.06E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536271(1-((2S,4R)-2-((R)-5-(2′-fluoro-[1,1′-b...)
Affinity DataIC50:  2.17E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536251((2R)-1-((2S,4R)-2-(5-(4-bromophenyl)-5-(trifluorom...)
Affinity DataIC50:  2.26E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536239((2R)-1-((4R)-2-(3,4-dihydro-2H,4'H-spiro[naphthale...)
Affinity DataIC50:  2.30E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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LigandPNGBDBM536244((5S)-2-((4R)-4-hydroxy-1-((methylsulfonyl)-L-proly...)
Affinity DataIC50:  2.33E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536218(US11242344, Example 107.2 | US11242344, Example 10...)
Affinity DataIC50:  2.41E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536215((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-phenyl-4,5...)
Affinity DataIC50:  2.45E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536264(1-((2S,4R)-2-(1-ethyl-5,5-dimethyl-4,5-dihydro-1H-...)
Affinity DataIC50:  2.57E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536232((5S)-2-((4R)-4-Hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Affinity DataIC50:  2.81E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
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