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Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552729(WO2022103411, Compound 52 | (2S,4R)-l-((S)-2-(4-cy...)
Affinity DataKd: <2.5nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552729(WO2022103411, Compound 52 | (2S,4R)-l-((S)-2-(4-cy...)
Affinity DataKd: <2.5nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50637018(CHEMBL5568085)
Affinity DataKd: <2.5nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 2 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50637018(CHEMBL5568085)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552702((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataKd:  3.30nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50642739(CHEMBL5575147)
Affinity DataKd:  3.40nMAssay Description:Binding affinity to VHL (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552702((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataKd:  3.90nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552708((2S,4R)-l-((S)-2-cyclohexyl-2-(4-cyclopropyl-lH-l,...)
Affinity DataIC50: 5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552729(WO2022103411, Compound 52 | (2S,4R)-l-((S)-2-(4-cy...)
Affinity DataIC50: 5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552704((2S,4R)-l-((2S)-2-(adamantan-l-yl)-2-(4-cyclopropy...)
Affinity DataIC50: 5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552703((2S,4R)-l-((S)-2-cyclohexyl-2-(4-cyclopropyl-lH-l,...)
Affinity DataIC50: 5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552705((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l ,2,3-triazol-...)
Affinity DataIC50: 5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552686((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataKd:  6.30nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552686((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM454975(US10730870, Example 145)
Affinity DataKd:  7nMAssay Description:Binding affinity to NanoLuc-fused VHL (unknown origin) transfected in live HEK293 cells using NanoGlo as substrate assessed as dissociation constant ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM454975(US10730870, Example 145)
Affinity DataIC50: 8nMAssay Description:Inhibition of NanoLuc-fused VHL (unknown origin) transfected in live HEK293 cells using NanoGlo as substrate incubated for 1 hrs by tracer based Nano...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552726(WO2022103411, Compound 47 | (2S,4R)-l-((S)-2-(4-cy...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552711((2S,4R)-l-((S)-3,3-dimethyl-2-(4-(l-methylcyclopro...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM454969(US10730870, Example 138 | US10730870, Example 145 ...)
Affinity DataKd:  10nMAssay Description:The surface plasmon resonance (SPR) experiments were conducted on a Biacore3000 (GE Healthcare). His-tagged VHL protein was immobilized on a carboxym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552686((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50: 10nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552702((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552731(WO2022103411, Compound 54 | (2S, 4R)-N-((S)-l-(2'-...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552706((2S,4R)-N-(l-(2-chloro-4-(4-methylthia7,ol-5-yl)ph...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552686((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50404375(CHEMBL5274307)
Affinity DataKd:  11nMAssay Description:Binding affinity to human VHL by isothermal calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454848(US10730870, Example 11 | US11512083, Example 11)
Affinity DataIC50: 16.3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM454848(US10730870, Example 11 | US11512083, Example 11)
Affinity DataIC50: 16.3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552709((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50: 20nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552687((2S,4R)-l-((S)-2-(4-benzyl-lH-l,2,3-triazol-l-yl)-...)
Affinity DataIC50: 20nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552712(WO2022103411, Compound 30 | WO2022103411, Example ...)
Affinity DataIC50: 20nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552687((2S,4R)-l-((S)-2-(4-benzyl-lH-l,2,3-triazol-l-yl)-...)
Affinity DataIC50: 20nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552707((2S,4R)-l-((2S)-2-(adamantan-l-yl)-2-(4-cyclopropy...)
Affinity DataIC50: 20nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50615679(CHEMBL4449823)
Affinity DataIC50: 27nMAssay Description:Binding affinity to VHL (unknown origin) incubated for 60 mins by FP based binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50615681(CHEMBL5277721)
Affinity DataIC50: 29nMAssay Description:Binding affinity to VHL (unknown origin) incubated for 60 mins by FP based binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552728(WO2022103411, Compound 49 | (2S, 4R)-l-((S)-2-(4-c...)
Affinity DataIC50: 30nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  34nMAssay Description:Binding affinity to N-terminal His6-tagged VHL (54 to 213 residues) (unknown origin) expressed in Escherichia coli assessed as displacement of HIF-1a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  34nMAssay Description:Binding affinity to N-terminal His6-tagged VHL (54 to 213 residues) (unknown origin) expressed in Escherichia coli assessed as displacement of HIF-1a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50637350(CHEMBL5537069)
Affinity DataKd:  37nMAssay Description:Binding affinity to VHL (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM552710((2S,4R)-l-((S)-3,3-dimethyl-2-(4-(l-(trifluorometh...)
Affinity DataIC50: 40nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50637339(CHEMBL5557146)
Affinity DataKd:  43nMAssay Description:Binding affinity to NanoLuc-fused VHL (unknown origin) transfected in live HEK293 cells using NanoGlo as substrate assessed as dissociation constant ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50459943(CHEMBL4225470)
Affinity DataKd:  44nMAssay Description:Binding affinity to VHL (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50586757(CHEMBL5089280)
Affinity DataKd:  45nMAssay Description:Binding affinity to VHL (unknown origin) assessed as displacement of HIF-1alpha by binary binding competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50611349(CHEMBL5283149)
Affinity DataKd:  47nMAssay Description:Binding affinity to VHL (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataKd:  58nMAssay Description:Displacement of FAM-labeled HIF-1alpha peptide from VCB (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50637013(CHEMBL5561098)
Affinity DataKd:  59nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 2 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50637015(CHEMBL5557410)
Affinity DataKd:  63nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 2 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50615684(CHEMBL4565531)
Affinity DataKd:  63nMAssay Description:Binding affinity to NanoLuc-fused VHL (unknown origin) transfected in live HEK293 cells using NanoGlo as substrate assessed as dissociation constant ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50581599(CHEMBL5087181)
Affinity DataKd:  63nMAssay Description:Binding affinity to N-terminal His6-tagged VHL (54 to 213 residues) (unknown origin) expressed in Escherichia coli assessed as displacement of HIF-1a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50637352(CHEMBL5527921)
Affinity DataKd:  63nMAssay Description:Binding affinity to VHL (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50581597(CHEMBL5074720)
Affinity DataKd:  66nMAssay Description:Binding affinity to N-terminal His6-tagged VHL (54 to 213 residues) (unknown origin) expressed in Escherichia coli assessed as displacement of HIF-1a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
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