Compile Data Set for Download or QSAR
Report error Found 659 of affinity data for UniProtKB/TrEMBL: P42681
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  2.10nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31090((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...)
Affinity DataKd:  5.50E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM26474(GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...)
Affinity DataKd:  2.60E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataKd:  6.00E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM13336(4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]...)
Affinity DataKd:  4.50E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  230nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  2.70E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd:  3.70E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434514(US10562893, Compound 1)
Affinity DataEC50:  55nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434515(US10562893, Compound 2)
Affinity DataEC50: <10nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434516(US10562893, Compound 3)
Affinity DataEC50:  55nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434517(US10562893, Compound 9)
Affinity DataEC50: <10nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434518(US10562893, Compound 11)
Affinity DataEC50: <10nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
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TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434519(US10562893, Compound 12)
Affinity DataEC50:  55nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434520(US10562893, Compound 16)
Affinity DataEC50: <10nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434521(US10562893, Compound 17)
Affinity DataEC50: <10nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434522(US10562893, Compound 18)
Affinity DataEC50: <10nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434523(US10562893, Compound 19)
Affinity DataEC50:  55nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434524(US10562893, Compound 25)
Affinity DataEC50: <10nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434525(US10562893, Compound 27)
Affinity DataEC50: >100nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434526(US10562893, Compound 28)
Affinity DataEC50: <10nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434527(US10562893, Compound 31)
Affinity DataEC50: <10nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434528(US10562893, Compound 38)
Affinity DataEC50: <10nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434529(US10562893, Compound 42)
Affinity DataEC50:  55nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434530(US10562893, Compound 43)
Affinity DataEC50: <10nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434531(US10562893, Compound 50)
Affinity DataEC50: <10nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434532(US10562893, Compound 62)
Affinity DataEC50:  55nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434533(US10562893, Compound 68)
Affinity DataEC50: <10nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434534(US10562893, Compound 77)
Affinity DataEC50: <10nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM434535(US10562893, Compound 81)
Affinity DataEC50:  55nMAssay Description:RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  1.01E+3nMAssay Description:Binding affinity to recombinant human N-terminal GST-tagged TXK (260 to 527 residues) expressed in baculovirus expression system using srctide as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM348323(US9790229, Compound 46 | US10577374, Compound 46)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to wild-type human partial length TXK tyrosine kinase (L238 to W527 residues) expressed in bacterial expression system by Kinomescan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50522686(CHEMBL4564973)
Affinity DataKd:  530nMAssay Description:Binding affinity to wild-type human partial length TXK tyrosine kinase (L238 to W527 residues) expressed in bacterial expression system by Kinomescan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50524289(TCMDC-138471 | CHEMBL535429)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity to wild-type human partial length TXK (L238 to W527 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50588031(CHEMBL5207862)
Affinity DataKd:  2.50E+3nMAssay Description:Binding affinity to human partial length TXK (L238 to W527 residues ) expressed in bacterial expression system assessed dissociation constant by Kino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50588040(CHEMBL5196736)
Affinity DataKd:  5.70E+3nMAssay Description:Binding affinity to human partial length TXK (L238 to W527 residues ) expressed in bacterial expression system assessed dissociation constant by Kino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50588041(CHEMBL5179394)
Affinity DataKd:  3.60E+3nMAssay Description:Binding affinity to human partial length TXK (L238 to W527 residues ) expressed in bacterial expression system assessed dissociation constant by Kino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50588036(CHEMBL5175032)
Affinity DataKd:  86nMAssay Description:Binding affinity to human partial length TXK (L238 to W527 residues ) expressed in bacterial expression system assessed dissociation constant by Kino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50588042(CHEMBL5205957)
Affinity DataKd:  850nMAssay Description:Binding affinity to human partial length TXK (L238 to W527 residues ) expressed in bacterial expression system assessed dissociation constant by Kino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50588043(CHEMBL5182743)
Affinity DataKd:  1.60E+3nMAssay Description:Binding affinity to human partial length TXK (L238 to W527 residues ) expressed in bacterial expression system assessed dissociation constant by Kino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM348593(US9790229, Compound 316 | US10577374, Compound 316)
Affinity DataKd:  1.60E+3nMAssay Description:Binding affinity to human partial length TXK (L238 to W527 residues ) expressed in bacterial expression system assessed dissociation constant by Kino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataKd:  6.50E+3nMAssay Description:Binding affinity to TXK (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataKd:  0.620nMAssay Description:Binding affinity to TXK (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50175583(ACP-196 | Acalabrutinib | US9758524, Example 6 | U...)
Affinity DataKd:  24nMAssay Description:Binding affinity to TXK (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM250082(US9447106, 27b (peak 2) | US9556188, Compound 27a)
Affinity DataKd:  980nMAssay Description:Binding affinity to TXK (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM259407(US9512084, 6 | US10457647, Example 6 | US11180460,...)
Affinity DataKd:  1.70E+4nMAssay Description:Binding affinity to TXK (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50244495(CHEMBL4066176)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to TXK (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  10nMAssay Description:Binding affinity to human TXKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50126419(N*1*-[7-(4-Dimethylamino-phenyl)-[1,6]naphthyridin...)
Affinity DataKd:  395nMAssay Description:Binding affinity to human TXKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50273637(3-(4-amino-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  80nMAssay Description:Binding affinity to human TXKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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