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Report error Found 929 for UniProtKB: P23385
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 86211BDBM86211(NSC_40539 | CAS_52809-07-1 | Quisqualate)
Affinity DataKi:  0.0300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50224406BDBM50224406(9-(4-chlorophenyl)-2,3-dihydro-3(R)-methyl-1H-pyri...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345941BDBM50345941(9-(2-Methyl-allylamino)-3-p-tolyl-3H-pyrido[3',2':...)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50224407BDBM50224407(2,3-dihydro-9-(4-methoxyphenyl)-3(R)-methyl-1H-pyr...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50224391BDBM50224391(9-(4-chlorophenyl)-2,3-dihydro-1H-pyrimido[4'',5''...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50364723BDBM50364723(CHEMBL1951662)
Affinity DataKi:  0.400nMAssay Description:Antagonist activity at rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50002371BDBM50002371(Glutaminsaeure | glutamic acid | Glutamate | CHEMB...)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345942BDBM50345942(3-(4-Methoxy-phenyl)-9-(2-methyl-allylamino)-3H-py...)
Affinity DataKi:  0.400nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50224392BDBM50224392(9-(4-chlorophenyl)-2,3-dihydro-2(S)-methyl-1H-pyri...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50224395BDBM50224395(2,3-dihydro-9-(4-methylphenyl)-1H-pyrimido[4'',5''...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50224400BDBM50224400(2,3-dihydro-3(R)-methyl-9-(4-methylphenyl)-1H-pyri...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345947BDBM50345947(3-(4-Chloro-phenyl)-9-prop-2-ynylamino-3H-pyrido[3...)
Affinity DataKi:  0.600nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345950BDBM50345950(3-(4-Bromo-phenyl)-9-prop-2-ynylamino-3H-pyrido[3'...)
Affinity DataKi:  0.700nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345934BDBM50345934(9-Allylamino-3-(4-bromo-phenyl)-3H-pyrido[3',2':4,...)
Affinity DataKi:  0.700nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50171313BDBM50171313((3-Ethyl-2-methyl-quinolin-6-yl)-(4-methoxy-cycloh...)
Affinity DataKi:  0.870nMAssay Description:In vitro affinity for cloned rat metabotropic glutamate 1 receptors stably expressed on CHO cells determined using [3H]-R214127 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50379862BDBM50379862(CHEMBL2011870)
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50177100BDBM50177100(9-dimethylamino-3-cycoheptyl-3H-5-thia-1,3,6-triaz...)
Affinity DataIC50: 1nMAssay Description:Inhibition of rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50177080BDBM50177080(3-azepan-1-yl-9-dimethylamino-3H-pyrido[3',2':4,5]...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at rat mGluR1 expressed in 1321N1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50177063BDBM50177063(9-dimethylamino-3-(p-bromophenyl)-3H-5-thia-1,3,6-...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50224405BDBM50224405(2,3-dihydro-9-(4-methoxyphenyl)-1H-pyrimido[4'',5'...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345931BDBM50345931(9-Allylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':...)
Affinity DataKi:  1.10nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345933BDBM50345933(9-Allylamino-3-(4-chloro-phenyl)-3H-pyrido[3',2':4...)
Affinity DataKi:  1.10nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50089896BDBM50089896(CHEMBL315591 | LY367385 | 4-(Amino-carboxy-methyl)...)
Affinity DataKi:  1.18nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345940BDBM50345940(3-(4-Chloro-phenyl)-9-(2-methyl-allylamino)-3H-pyr...)
Affinity DataKi:  1.20nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50163606BDBM50163606(CHEMBL369459 | R 214127 | 1-(3,4-Dihydro-2H-1-oxa-...)
Affinity DataKi:  1.35nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50231744BDBM50231744(NPS 2390 | CHEMBL399160 | quinoxaline-2-carboxylic...)
Affinity DataKi:  1.36nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345943BDBM50345943(3-(4-Bromo-phenyl)-9-(2-methyl-allylamino)-3H-pyri...)
Affinity DataKi:  1.5nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50224396BDBM50224396(9-(4-chlorophenyl)-2,3-dihydro-3(S)-methyl-1H-pyri...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345948BDBM50345948(9-Prop-2-ynylamino-3-p-tolyl-3H-pyrido[3',2':4,5]t...)
Affinity DataKi:  1.60nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50030628BDBM50030628(CHEMBL444589 | 4-(Amino-carboxy-methyl)-2-hydroxy-...)
Affinity DataKi:  1.65nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50364720BDBM50364720(CHEMBL1951659)
Affinity DataKi:  1.90nMAssay Description:Antagonist activity at rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50364722BDBM50364722(CHEMBL1951661)
Affinity DataKi:  1.90nMAssay Description:Antagonist activity at rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 86212BDBM86212(NSC_104766 | CAS_104766 | 1S, 3R-ACPD)
Affinity DataKi:  1.92nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50163617BDBM50163617((2,3-Dihydro-thieno[2,3-b]quinolin-6-yl)-(4-methox...)
Affinity DataIC50: 2nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50177097BDBM50177097(9-Dimethylamino-3-p-tolyl-3H-pyrido[3',2':4,5]thie...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50197275BDBM50197275(N-(2-(4-fluorophenyl)-2-methylpropyl)quinoxaline-2...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50197248BDBM50197248(N-(2-methyl-2-phenylpropyl)-5,6,7,8-tetrahydroquin...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345955BDBM50345955(3-(4-Chloro-phenyl)-9-(2-methyl-allylamino)-3H-thi...)
Affinity DataKi:  2.20nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345966BDBM50345966(3-Benzo[b]thiophen-5-yl-9-(2-methyl-allylamino)-3H...)
Affinity DataKi:  2.30nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50224402BDBM50224402(8-(4-chlorophenyl)-1h-pyrrolo[2'',3'':4',5']pyrido...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345932BDBM50345932(9-Allylamino-3-p-tolyl-3H-pyrido[3',2':4,5]thieno[...)
Affinity DataKi:  2.70nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345956BDBM50345956(9-(2-Methyl-allylamino)-3-p-tolyl-3H-thieno[2,3-d:...)
Affinity DataKi:  2.90nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50177053BDBM50177053(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)
Affinity DataIC50: 3nMAssay Description:Inhibition of rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50163590BDBM50163590((2,3-Diethyl-quinolin-6-yl)-(4-methoxy-cyclohexyl)...)
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50197254BDBM50197254(N-((1r,4r)-4-methylcyclohexyl)-5-(piperidin-1-yl)p...)
Affinity DataKi:  3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50163590BDBM50163590((2,3-Diethyl-quinolin-6-yl)-(4-methoxy-cyclohexyl)...)
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50278288BDBM50278288(2-(2-(4-(2,3-dihydro-1H-inden-2-ylamino)pyrido[3,4...)
Affinity DataKi:  3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50163592BDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50197249BDBM50197249(N-(2-methyl-2-phenylpropyl)quinoxaline-2-carboxami...)
Affinity DataKi:  3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50163592BDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
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