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126 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands.EBI
Abbott Laboratories
Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 1.EBI
Abbott Laboratories
3,4-Diaza-bicyclo[4.1.0]hept-4-en-2-one phenoxypropylamine analogs of irdabisant (CEP-26401) as potent histamine-3 receptor inverse agonists with robust wake-promoting activity.EBI
Teva Global R & D.
Studies on molecular properties prediction and histamine H3 receptor affinities of novel ligands with uracil-based motifs.EBI
University Of Catania
Benzylpiperidine variations on histamine H3 receptor ligands for improved drug-likeness.EBI
Johann Wolfgang Goethe University
Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a): histamine H(3) receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity.EBI
Teva Pharmaceutical Global R & D
Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists.EBI
Glaxosmithkline
The discovery of the benzazepine class of histamine H3 receptor antagonists.EBI
Glaxosmithkline
Identification and profiling of 3,5-dimethyl-isoxazole-4-carboxylic acid [2-methyl-4-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)phenyl] amide as histamine H(3) receptor antagonist for the treatment of depression.EBI
Sanofi Us
Synthesis, characterization, and biological assessment of the four stereoisomers of the H(3) receptor antagonist 5-fluoro-2-methyl-N-[2-methyl-4-(2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]benzamide.EBI
Sanofi Us
Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part II).EBI
Sanofi Us
Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part I).EBI
Sanofi Us
Novel thiazolobenzodiazepines as inhibitors of histamine h3 receptor.EBI
Dart Neuroscience
Dibasic biphenyl H3 receptor antagonists: Steric tolerance for a lipophilic side chain.EBI
Universit£
Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: effects of substitution about the rigidifying ring.EBI
Abbott Laboratories
Diamine-based human histamine H3 receptor antagonists: (4-aminobutyn-1-yl)benzylamines.EBI
Johnson & Johnson Pharmaceutical Research & Development
Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity.EBI
Universit£
Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists.EBI
Abbott Laboratories
Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 2: binding preference for D-amino acids motifs.EBI
Abbott Laboratories
 
Diphenylmethyl ethers: synthesis and histamine H3-receptor antagonist in vitro and in vivo activityEBI
TBA
Radiofluorinated histamine H3 receptor antagonist as a potential probe for in vivo PET imaging: radiosynthesis and pharmacological evaluation.EBI
Eth Zurich (Swiss Federal Institute Of Technology)
Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764).EBI
Pfizer
Histamine H3 receptor as a drug discovery target.EBI
TBA
Synthesis and evaluation of 4- and 5-pyridazin-3-one phenoxypropylamine analogues as histamine-3 receptor antagonists.EBI
Cephalon
Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists.EBI
Cephalon
Synthesis of constrained benzocinnolinone analogues of CEP-26401 (irdabisant) as potent, selective histamine H3 receptor inverse agonists.EBI
Cephalon
2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one derivatives as potent and selective histamine-3 receptor antagonists.EBI
Pfizer
Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.EBI
National Institute Of Mental Health
Synthesis and evaluation of a new series of 1'-cyclobutyl-6-(4-piperidyloxy)spiro[benzopyran-2,4'-piperidine] derivatives as high affinity and selective histamine-3 receptor (H3R) antagonists.EBI
Cephalon
Synthesis and structure-activity relationships of 4,5-fused pyridazinones as histamine H3 receptor antagonists.EBI
Cephalon
Identification of pyridazin-3-one derivatives as potent, selective histamine H3 receptor inverse agonists with robust wake activity.EBI
Cephalon
Amine-constrained pyridazinone histamine H3 receptor antagonists.EBI
Cephalon
Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist.EBI
Cephalon
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relaEBI
Pfizer
Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.EBI
Johnson & Johnson Pharmaceutical Research & Development
5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.EBI
F. Hoffmann-La Roche
Diether derivatives of homo- or substituted piperidines as non-imidazole histamine H3 receptor ligands.EBI
Jagiellonian University Medical College
A new family of H3 receptor antagonists based on the natural product Conessine.EBI
Arena Pharmaceuticals
In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series.EBI
Abbott Laboratories
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.EBI
Universit£
4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention.EBI
Abbott Laboratories
Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties.EBI
Freie Universit£T Berlin
Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATE.EBI
De Novo Pharmaceuticals
Novel histamine H(3)-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds.EBI
Freie Universit£T Berlin
 
Diastereoselective synthesis of trans-2-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropanecarboxylic acids: key intermediates for the preparation of potent and chiral histamine H3 receptor agentsEBI
TBA
Novel morpholine ketone analogs as potent histamine H3 receptor inverse agonists with wake activity.EBI
Cephalon
4-phenoxypiperidine pyridazin-3-one histamine H(3) receptor inverse agonists demonstrating potent and robust wake promoting activity.EBI
Cephalon
Synthesis and structure-activity relationship of 5-pyridazin-3-one phenoxypiperidines as potent, selective histamine H(3) receptor inverse agonists.EBI
Cephalon
Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: discovery of (R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916).EBI
Arena Pharmaceuticals
Ligand based design of novel histamine H4 receptor antagonists; fragment optimization and analysis of binding kinetics.EBI
Griffin Discoveries
Synthesis and evaluation of 4-alkoxy-[1'-cyclobutyl-spiro(3,4-dihydrobenzopyran-2,4'-piperidine)] analogues as histamine-3 receptor antagonists.EBI
Cephalon
4,5-dihydropyridazin-3-one derivatives as histamine H3 receptor inverse agonists.EBI
Cephalon
Synthesis and evaluation of pyridone-phenoxypropyl-R-2-methylpyrrolidine analogues as histamine H3 receptor antagonists.EBI
Cephalon
Synthesis and evaluation of pyridazinone-phenethylamine derivatives as selective and orally bioavailable histamine H3 receptor antagonists with robust wake-promoting activity.EBI
Cephalon
Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists.EBI
Johnson & Johnson Pharmaceutical Research And Development
Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain.EBI
Abbott Laboratories
Discovery of potent and selective histamine H3 receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold.EBI
F. Hoffmann-La Roche
Discovery of substituted benzyl tetrazoles as histamine H3 receptor antagonists.EBI
Evotec (Uk)
In vitro studies on a class of quinoline containing histamine H3 antagonists.EBI
Abbott Laboratories
Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists.EBI
Johnson & Johnson Pharmaceutical Research & Development
Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates.EBI
Jagiellonian University Medical College
Benzimidazole- and indole-substituted 1,3'-bipyrrolidine benzamides as histamine H3 receptor antagonists.EBI
Wyeth Research
Design and evaluation of novel biphenyl sulfonamide derivatives with potent histamine H(3) receptor inverse agonist activity.EBI
Arena Pharmaceuticals
Synthesis, structure-activity relationships, and biological profiles of a dihydrobenzoxathiin class of histamine H(3) receptor inverse agonists.EBI
Tsukuba Research Institute
Development of a selective and potent radioactive ligand for histamine H(3) receptors: A compound potentially useful for receptor occupancy studies.EBI
Tsukuba Research Institute
Design of a new histamine H3 receptor antagonist chemotype: (3aR,6aR)-5-alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, synthesis, and structure-activity relationships.EBI
Abbott Laboratories
2-Aryloxymethylmorpholine histamine H(3) antagonists.EBI
Johnson & Johnson Pharmaceutical Research & Development
 
Imetit and N-methyl derivatives. The transition from potent agonist to antagonist at histamine H3 receptors.1EBI
TBA
Novel imidazole-based histamine H3 antagonists.EBI
Johnson & Johnson Pharmaceutical Research & Development
Synthesis and evaluation of structurally constrained quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists.EBI
Tsukuba Research Institute
Total synthesis and biological evaluation of the marine bromopyrrole alkaloid dispyrin: elucidation of discrete molecular targets with therapeutic potential.EBI
Vanderbilt University
Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine H3 receptor inverse agonists.EBI
Tsukuba Research Institute
Novel H3 receptor antagonists with improved pharmacokinetic profiles.EBI
Arena Pharmaceuticals
Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H3 receptor antagonists. Part I.EBI
Kyowa Hakko Kogyo
Synthesis, potency, and in vivo profiles of quinoline containing histamine H3 receptor inverse agonists.EBI
Abbott Laboratories
A new class of histamine H3 receptor antagonists derived from ligand based design.EBI
F. Hoffmann-La Roche
4-[6-(2-Aminoethyl)naphthalen-2-yl]benzonitriles are potent histamine H3 receptor antagonists with high CNS penetration.EBI
Abbott Laboratories
Synthesis and SAR of novel histamine H3 receptor antagonists.EBI
Eli Lilly
Aplysamine-1 and related analogs as histamine H3 receptor antagonists.EBI
Johnson & Johnson Pharmaceutical Research And Development
Synthesis and SAR of 5-amino- and 5-(aminomethyl)benzofuran histamine H3 receptor antagonists with improved potency.EBI
Abbott Laboratories
Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain.EBI
University College London
4-(omega-(alkyloxy)alkyl)-1H-imidazole derivatives as histamine H(3) receptor antagonists/agonists.EBI
Freie UniversitäT Berlin
A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans.EBI
Abbott Laboratories
Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists.EBI
Abbott Laboratories
A new class of histamine H(3)-receptor antagonists: synthesis and structure-activity relationships of 7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolines.EBI
Abbott Laboratories
Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a highly selective agonist for the histamine H3 receptor, having a cis-cyclopropane structure.EBI
Hokkaido University
Structural modifications in the distal, regulatory region of histamine HEBI
Jagiellonian University Medical College
Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases.EBI
Soochow University
Novel human histamine H(3) receptor antagonists.EBI
Johnson And Johnson Pharmaceutical Research And Development
Synthesis and evaluation of potent pyrrolidine H(3) antagonists.EBI
Abbott Laboratories
Different antagonist binding properties of human and rat histamine H3 receptors.EBI
Freie UniversitäT Berlin
Analogues and derivatives of ciproxifan, a novel prototype for generating potent histamine H3-receptor antagonists.EBI
Freie UniversitäT Berlin
New histamine H(3)-receptor ligands of the proxifan series: imoproxifan and other selective antagonists with high oral in vivo potency.EBI
Freie UniversitäT Berlin
Novel partial agonists for the histamine H(3) receptor with high in vitro and in vivo activity.EBI
Freie UniversitäT Berlin
Discovery of novel steroidal histamine HEBI
Chemical Works Of Gedeon Richter
Design, synthesis, and structure-activity relationships of acetylene-based histamine H3 receptor antagonists.EBI
Gliatech
Development of chiral N-alkylcarbamates as new leads for potent and selective H3-receptor antagonists: synthesis, capillary electrophoresis, and in vitro and oral in vivo activity.EBI
Freie UniversitäT Berlin
Discovery and Development of N-[4-(1-Cyclobutylpiperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide Dihydrochloride (SUVN-G3031): A Novel, Potent, Selective, and Orally Active Histamine HEBI
Suven Life Sciences
General construction pattern of histamine H3-receptor antagonists: change of a paradigm.EBI
Freie UniversitäT Berlin
New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine.EBI
Gliatech
4-Alkynylphenyl imidazolylpropyl ethers as selective histamine H3-receptor antagonists with high oral central nervous system activity.EBI
Freie UniversitäT Berlin
Synthesis and evaluation of histamine HEBI
Jiangsu Marine Resources Development Research Institute
A novel series of (phenoxyalkyl)imidazoles as potent H3-receptor histamine antagonists.EBI
University College London
Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity.EBI
Freie UniversitäT Berlin
[125I]iodoproxyfan and related compounds: a reversible radioligand and novel classes of antagonists with high affinity and selectivity for the histamine H3 receptor.EBI
Freie UniversitäT Berlin
Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.EBI
Solvay Duphar
Non-imidazole histamine HEBI
Medical University
Design of potent non-thiourea H3-receptor histamine antagonists.EBI
University College London
Dibasic non-imidazole histamine H3 receptor antagonists with a rigid biphenyl scaffold.EBI
Universit£
Synthesis and in vitro pharmacology of a series of new chiral histamine H3-receptor ligands: 2-(R and S)-Amino-3-(1H-imidazol-4(5)-yl)propyl ether derivatives.EBI
University Of Kuopio
Characterization of the binding site of the histamine H3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)- and (1S,2S)-2-(1H-imidazol-4-yl)-cyclopropylamine.EBI
Vrije Universiteit
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics.EBI
Huazhong University Of Science And Technology
Design, synthesis, and biological evaluation of novel oxadiazole- and thiazole-based histamine HEBI
Heinrich Heine University D£Sseldorf
Synthesis and biological activity of novel tert-amylphenoxyalkyl (homo)piperidine derivatives as histamine HEBI
Jagiellonian University Medical College
Novel naphthyloxy derivatives - Potent histamine HEBI
Jagiellonian University Medical College
Histamine H3 ligands: just pharmacological tools or potential therapeutic agents?EBI
Vrije Universiteit
Identification and pharmacological characterization of a series of new 1H-4-substituted-imidazoyl histamine H3 receptor ligands.BDB
Gliatech
Stable expression of human H1-histamine-receptor cDNA in Chinese hamster ovary cells. Pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene.BDB
UniversitÉ
Muscarinic cholinergic binding in rat brain.BDB
TBA
The characterization of [3H]sulpiride binding sites in rat striatal membranes.BDB
St, Marianna University School Of Medicine