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Compounds Sorted by Binding Targets per Compound

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304   310   315   323   339   369   370   371   372   373   374   375   376   377   378   380   381   383   384   
385   386   388   389   390   391   392   393   394   395   397   398   401   403   404   406   408   418   427   
429   443   447   515   
Compounds Sorted Alphabetically
Compound Name (alphabetical)
Binding Targets
Enz. Inhib. Data
ITC Data
Alternate Compound Names
  • Coagulation factor X
  • Coagulation factor XI
  • Coagulation factor XII
  • Complement C1r
  • Complement C1s
  • Factor XIIa
  • Plasma kallikrein
  • Plasminogen
  • Prothrombin
  • Tissue-type plasminogen activator
  • Transcription initiation factor IIA
  • Vitamin K-dependent protein C
20 Ki
  • US8598206, Table 6, 19
  • Carbonic Anhydrase (hpCA)
  • Carbonic Anhydrase (mtCA 1)
  • Carbonic Anhydrase (mtCA 3)
  • Carbonic Anhydrase 2 (Can2)
  • Carbonic Anhydrase VA
  • Carbonic Anhydrase VB
  • Carbonic Anhydrase XV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Carbonic anhydrase 6 (CA-VI)
  • Carbonic anhydrase 9
  • beta-Carbonic Anhydrase
15 Ki
  • 2-methoxy-N-[(1-methylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide
  • Sulmepride
  • Sulpiride (SLP)
  • Acetylcholinesterase
  • Acyl-CoA: cholesterol acyltransferase (ACAT)
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • Carboxylesterase 1
  • Cholinesterases
  • Chorismate mutase (MTB CM)
  • Factor XIIa
  • Monoamine Oxidase Type B (MAO-B)
  • Monoamine oxidase type B (MAO-B) Mutant (I199F)
  • Protein-glutamine gamma-glutamyltransferase 2 (TG2)
  • Transthyretin
19 Ki 19 IC50
  • 2,3-dihydro-1H-indole-2,3-dione
  • CHEMBL326294
  • Isatin
  • Isatin (Compound 1)
  • 5-hydroxytryptamine receptor 2B
  • CREB-binding protein/p53
  • DNA-dependent protein kinase
  • PI3K p110 delta/p85 alpha
  • Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR
  • Phosphatidylinositol 3-kinase catalytic subunit type 3
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  • Phosphatidylinositol 4-kinase beta
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
31 IC50
  • US8653092, 67
  • Cereblon/Histone deacetylase 6
  • Histone deacetylase 1
  • Histone deacetylase 10
  • Histone deacetylase 11
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
  • Prostaglandin E2 receptor EP2 subtype
1 Ki 11 IC50
  • BDBM119696
  • US8685986, 15
  • CDK2/CycE
  • CDK2/Cyclin A/Cyclin A1
  • Cyclin-Dependent Kinase 1 (CDK1)
  • Cyclin-Dependent Kinase 2 (CDK2)
  • Cyclin-Dependent Kinase 4 (CDK4)
  • Cyclin-Dependent Kinase 7 (CDK7)
  • Cyclin-Dependent Kinase 9 (CDK9)
  • Cyclin-dependent kinase 1
  • Cyclin-dependent kinase 2
  • Cyclin-dependent kinase 4
  • Cyclin-dependent kinase 7
  • Cyclin-dependent kinase 9
2 Ki 11 IC50
  • 4-Arylazo-3,5-diamino-1H-pyrazole 31b
  • 4-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]phenol
  • CAN508
  • 3C-like proteinase
  • Calmodulin/Proto-oncogene tyrosine-protein kinase Src
  • Ephrin type-A receptor 2 (EPHA2)
  • Epidermal growth factor receptor
  • Mast/stem cell growth factor receptor Kit
  • Proto-oncogene tyrosine-protein kinase Src
  • Tyrosine- and threonine-specific cdc2-inhibitory kinase
  • Tyrosine-protein kinase ABL1
  • Tyrosine-protein kinase CSK
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase Yes
  • Vascular endothelial growth factor receptor 2
2 Ki 26 IC50 2 Kd 1 EC50
  • AZD0530
  • CHEMBL217092
  • Compound 33
  • N-(5-chloro-2H-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(oxan-4-yloxy)quinazolin-4-amine
  • Saracatinib
  • med.21724, Compound 189
  • Cyclin-dependent kinase 2
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor
  • Focal adhesion kinase 1
  • MAP kinase p38
  • Proto-oncogene tyrosine-protein kinase Src
  • Receptor tyrosine-protein kinase erbB-2
  • Tyrosine-protein kinase Fyn
  • Tyrosine-protein kinase HCK
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase Lck
  • Vascular endothelial growth factor receptor 2
16 IC50
  • 5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3-thiazole-2,5-diamido
  • BMS-354825 2-Carboxamido-4-hydrido-thiazole Analog 7n
  • CHEMBL131577
  • N-(2-chloro-6-methylphenyl)-2-[(cyclopropylcarbonyl)amino]-1,3-thiazole-5-carboxamide
  • Cyclin-dependent kinase 2
  • Glycogen synthase kinase-3
  • Inhibitor of nuclear factor kappa-B kinase subunit beta
  • Mitogen-activated protein kinase 10
  • RAC-alpha serine/threonine-protein kinase
  • Rho-associated protein kinase 1
  • Rho-associated protein kinase 2
  • Ribosomal protein S6 kinase alpha 1
  • Ribosomal protein S6 kinase alpha 5
  • Serine/threonine-protein kinase AKT
  • Serine/threonine-protein kinase AKT2
  • Serine/threonine-protein kinase PLK1
14 IC50
  • Aminofurazanyl-azabenzimidazole 6n
  • N-(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-[2-(morpholin-4-yl)ethoxy]benzamide
  • Beta-secretase 1
  • Nck adaptor protein 1
  • Neutrophil cytosol factor 1
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase I218V
  • Nitric oxide synthase, inducible
  • Serotonin (5-HT) receptor
  • Serotonin 2 (5-HT2) receptor
  • Trypsin
  • Tryptase
  • Tyrosine-protein kinase HCK
  • Tyrosine-protein kinase TEC
5 Ki 5 IC50 4 Kd 3 EC50 1 Other
  • 2-Aminoquinoline 1
  • 2-aminoquinoline
  • CHEMBL61236
  • Fragment 19
  • Quinolin-2-amine
  • fragment 2 (J. med. chem.,50,1116)
  • quinolin-2-amine
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
  • Mitogen-activated protein kinase 14
  • Phosphodiesterase 8
  • Phosphodiesterase Type 10 (PDE10A)
  • Phosphodiesterase Type 11 (PDE11A)
  • Phosphodiesterase Type 2 (PDE2A)
  • Phosphodiesterase Type 3 (PDE3B)
  • Phosphodiesterase Type 4 (PDE4B)
  • Phosphodiesterase Type 4 (PDE4D)
  • Phosphodiesterase Type 5 (PDE5A)
  • Phosphodiesterase Type 7 (PDE7B)
  • Phosphodiesterase Type 9 (PDE9A)
12 IC50
  • (E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylidene}amino carbamate
  • Filaminast
  • [1-(3-cyclopentyloxy-4-methoxy-phenyl)ethylideneamino] carbamate
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
  • Phosphodiesterase 8
  • Phosphodiesterase Type 10 (PDE10A)
  • Phosphodiesterase Type 11 (PDE11A)
  • Phosphodiesterase Type 2 (PDE2A)
  • Phosphodiesterase Type 3 (PDE3B)
  • Phosphodiesterase Type 4 (PDE4B)
  • Phosphodiesterase Type 4 (PDE4D)
  • Phosphodiesterase Type 5 (PDE5A)
  • Phosphodiesterase Type 7 (PDE7B)
  • Phosphodiesterase Type 9 (PDE9A)
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
2 Ki 11 IC50
  • 4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclohexane-1-carboxylic acid
  • 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylic acid
  • Ariflo
  • Cilomilast
  • SB207499
  • Acetylcholinesterase
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • Cholinesterases
  • Cytochrome P450 2B1
  • Monoamine Oxidase Type A (MAO-A)
  • Monoamine Oxidase Type B (MAO-B)
  • Monoamine oxidase
  • Monoamine oxidase A
  • Monoamine oxidase B
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
  • Sigma non-opioid intracellular receptor 1
17 Ki 174 IC50
  • CHEMBL8706
  • CLG
  • CLORGILINE
  • Clorgyline
  • N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-prop-2-yn-1-amine
  • US8633208, Clorgyline
  • US9603833, Clorgyline
  • [3-(2,4-dichlorophenoxy)propyl](methyl)prop-2-yn-1-ylamine
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Monoamine Oxidase Type A (MAO-A)
  • Monoamine Oxidase Type B (MAO-B)
  • Monoamine oxidase
  • Multidrug resistance-associated protein 4
  • Potassium voltage-gated channel subfamily H member 2
  • Sigma intracellular receptor 2
  • Sigma non-opioid intracellular receptor 1
33 Ki 51 IC50
  • 4-chloro-N-(2-morpholin-4-ylethyl)benzamide
  • 4-chloro-N-[2-(morpholin-4-yl)ethyl]benzamide
  • Aurorix
  • CHEMBL86304
  • MCL
  • Moclobemide
  • Chymase
  • Chymotrypsin
  • Coagulation factor X
  • Glandular kallikrein
  • Plasminogen
  • Prothrombin
  • Thrombin
  • Trypsin
  • Trypsin-1
  • Tryptase
  • Tryptase beta-1/beta-2
  • Urokinase-type plasminogen activator
23 Ki 4 IC50
  • 2,2 -methanediylbis(1H-benzimidazole-6-carboximidamide)
  • 2-[(6-carbamimidoyl-1H-1,3-benzodiazol-2-yl)methyl]-1H-1,3-benzodiazole-6-carboximidamide
  • AIDS007118
  • BABIM
  • CHEMBL542712
  • CHEMBL99951
  • Inhibitor of nuclear factor kappa-B kinase subunit beta
  • MAP kinase-activated protein kinase 2
  • Mitogen-activated protein kinase 11
  • Mitogen-activated protein kinase 14
  • Protein kinase C alpha type
  • Protein kinase C delta type
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase SYK
  • Tyrosine-protein kinase ZAP-70
  • Vascular endothelial growth factor receptor 2
  • cAMP-dependent protein kinase (PKA)
1 Ki 12 IC50
  • 3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-methyl-1,4-diazepan-1-yl)-1,3,5-triazin-2-yl}amino)-N-methoxy-4-methylbenzamide
  • CHEMBL225088
  • triaminotriazine aniline amide inhibitor, 1
  • Acetylcholinesterase
  • Aldose Reductase (ALR2) Mutant (C298A/W219Y)
  • Aldose reductase (AR)
  • Alpha-glucosidase MAL62
  • Beta amyloid A4 protein
  • Beta-ketoacyl-ACP synthase III (FabH)
  • Dihydroorotate dehydrogenase (fumarate)
  • Histone deacetylase
  • Hydroxycarboxylic acid receptor 2
  • Tankyrase 1/2
  • Tyrosinase
  • Xanthine dehydrogenase
4 Ki 10 IC50
  • (2E)-3-phenylprop-2-enoic acid
  • CHEMBL27246
  • Cinnamic acid
  • Zimtsaeure
  • Zimtsaeure | trans-Cinnamate
  • t-Cinnamic acid
  • trans-Cinnamate
  • 1,3-beta-glucan synthase component GLS2
  • Cytoplasmic tyrosine-protein kinase BMX
  • Epidermal growth factor receptor
  • Receptor protein-tyrosine kinase erbB-4
  • Receptor tyrosine-protein kinase erbB-2
  • TEC family kinase
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase ITK/TSK
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase TEC
  • VHL/EGFR
  • VHL/Tyrosine-protein kinase BTK
1 Ki 23 IC50 8 Kd
  • BDBM166759
  • US10604504, Example 223
  • US9688629, 123
  • US9802915, Example 123
  • US9920031, Example 223
  • 3-phosphoinositide dependent protein kinase-1
  • Axin-1/Glycogen synthase kinase-3 beta
  • Checkpoint Kinase (Chk2)
  • Cyclin-Dependent Kinase 1 (CDK1)
  • Cyclin-Dependent Kinase 2 (CDK2)
  • Cyclin-dependent kinase 1
  • Cyclin-dependent kinase 5 regulatory subunit 1
  • Mitogen-activated protein kinase 1
  • RAC-alpha serine/threonine-protein kinase
  • Serine/threonine-protein kinase CHK2
  • Serine/threonine-protein kinase Chk1/2
  • cAMP-dependent protein kinase (PKA)
1 Ki 15 IC50
  • (4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-ylidene)-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one
  • 2-amino-5-[(4Z)-8-oxo-1H,4H,5H,6H,7H,8H-pyrrolo[2,3-c]azepin-4-ylidene]-4,5-dihydro-1H-imidazol-4-one
  • B722657K110
  • CHEMBL255465
  • Debromohymenialdisine (DBH)
  • Hymenialdisine, 8
  • NSC607174
  • MAP kinase p38
  • Mitogen-activated protein kinase 10
  • Mitogen-activated protein kinase 14
  • Mitogen-activated protein kinase 3
  • Non-receptor tyrosine-protein kinase TYK2
  • Proto-oncogene tyrosine-protein kinase Src
  • Tyrosine-protein kinase Fyn
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase Lyn
14 IC50
  • 1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(piperidin-4-yl)-1,2,3,4-tetrahydroquinazolin-2-one
  • CHEMBL319556
  • Dihydro-quinazolinone analog, 9
  • 5-hydroxytryptamine receptor 1A (5HT1A)
  • 5-hydroxytryptamine receptor 1D (5HT1D)
  • 5-hydroxytryptamine receptor 2A (5HT2A)
  • 5-hydroxytryptamine receptor 2B (5HT2B)
  • 5-hydroxytryptamine receptor 2C (5HT2C)
  • Alpha-1A adrenergic receptor
  • Alpha-1B adrenergic receptor
  • Alpha-1D adrenergic receptor
  • D(2) dopamine receptor
  • Dopamine D1 receptor
  • Dopamine D3 receptor
  • Dopamine D4 receptor
12 Ki
  • US9079895, 23s
  • 5-hydroxytryptamine receptor 1A (5HT1A)
  • 5-hydroxytryptamine receptor 1D (5HT1D)
  • 5-hydroxytryptamine receptor 2A (5HT2A)
  • 5-hydroxytryptamine receptor 2B (5HT2B)
  • 5-hydroxytryptamine receptor 2C (5HT2C)
  • Alpha-1A adrenergic receptor
  • Alpha-1D adrenergic receptor
  • D(2) dopamine receptor
  • Dopamine D1 receptor
  • Dopamine D3 receptor
  • Dopamine D4 receptor
  • Dopamine D5 receptor
12 Ki
  • US9079895, 25s
  • Bromodomain adjacent to zinc finger domain protein 2B
  • Bromodomain-containing protein 4
  • Bromodomain-containing protein 9
  • CREB-binding protein
  • CREB-binding protein/Histone acetyltransferase p300
  • CREB-binding protein/p53
  • HIF1A/p300/CREB-binding protein
  • Histone acetyltransferase KAT2A/KAT2B
  • Histone acetyltransferase p300
  • Histone acetyltransferase p300/Hypoxia-inducible factor 1-alpha
  • Transcription initiation factor TFIID subunit 1
  • Transcription intermediary factor 1-alpha
21 IC50 7 Kd 1 EC50
  • SGC-CBP30
  • Androgen Receptor
  • Bile salt export pump
  • Organic anion-transporting polypeptide 1D1 (Oatp1d1)
  • Peroxisome proliferator-activated receptor
  • Proliferating cell nuclear antigen
  • Prothrombin
  • Solute carrier organic anion transporter family member 1A4
  • Solute carrier organic anion transporter family member 1C1
  • Thyroid hormone receptor alpha
  • Thyroid hormone receptor apha
  • Thyroid hormone receptor beta
  • thyroid beta
11 Ki 20 IC50 13 Kd 25 EC50
  • (2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
  • (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
  • 3,5,3'-triiodo-L-thyronine (T3)
  • CHEMBL1544
  • Triiodothyronine
  • Triiodothyronine (T3)
  • US10544075, Compound T3
  • [125I]T3
  • liothyronine
  • triothyrone
  • Alpha-chymotrypsin
  • Beta-lactamase AmpC
  • Cruzipain
  • HIV-1 Reverse Transcriptase
  • HIV-1 Reverse Transcriptase Mutant (K103N)
  • HIV-1 Reverse Transcriptase Mutant (P236L)
  • HIV-1 Reverse Transcriptase Mutant (Y181C)
  • Human immunodeficiency virus type 1 reverse transcriptase
  • Integrase
  • Malate dehydrogenase cytoplasmic
  • Reverse Transcriptase
  • Reverse transcriptase
40 IC50 3 EC50
  • BHAP deriv.
  • CHEMBL593
  • DELAVIRDINE MESYLATE
  • Delavirdine
  • N-[2-({4-[3-(propan-2-ylamino)pyridin-2-yl]piperazin-1-yl}carbonyl)-1H-indol-5-yl]methanesulfonamide
  • Rescriptor
  • U-90152S
  • Histone lysine demethylase PHF8
  • Lysine-specific demethylase 2B
  • Lysine-specific demethylase 3B
  • Lysine-specific demethylase 3B (KDM3B)
  • Lysine-specific demethylase 4C
  • Lysine-specific demethylase 4C (KDM4C)
  • Lysine-specific demethylase 5A
  • Lysine-specific demethylase 5B
  • Lysine-specific demethylase 5C
  • Lysine-specific demethylase 6A (KDM6A)
  • Lysine-specific demethylase 6B
  • Lysine-specific demethylase 7A/7B
32 IC50 2 EC50
  • CPI-455
  • Histone Lysine Demethylase
  • Lysine-specific demethylase 3A
  • Lysine-specific demethylase 4A (KDM4A)
  • Lysine-specific demethylase 4C
  • Lysine-specific demethylase 4D
  • Lysine-specific demethylase 5A (KDM5A)
  • Lysine-specific demethylase 5B
  • Lysine-specific demethylase 5C
  • Lysine-specific demethylase 5C (KDM5C)
  • Lysine-specific demethylase 5D (KDM5D)
  • Lysine-specific demethylase 6B
  • Prolyl hydroxylase EGLN3
17 IC50
  • GSK467
  • Cereblon/Histone deacetylase 6
  • HDAC6 (CD1-CD2)
  • Histone deacetylase 1
  • Histone deacetylase 10
  • Histone deacetylase 11
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
12 IC50
  • R-TSA
  • Cereblon/Histone deacetylase 6
  • HDAC6 (CD1-CD2)
  • Histone deacetylase 1
  • Histone deacetylase 10
  • Histone deacetylase 11
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
12 IC50
  • S-TSA
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA)
  • Alpha-crystallin B chain
  • GluN1/GluN2B NMDA receptor
  • HMG-CoA reductase
  • ITGAV/ITGB3
  • NR1/NR2A
  • Niemann-Pick C1-like protein 1
  • Nuclear receptor ROR-gamma (RORC)
  • OSBP-related protein 4 (ORP4L)
  • OSBP-related protein 4 (ORP4S)
  • Oxysterols receptor LXR-alpha
  • Sterol regulatory element-binding protein 2
2 IC50 3 Kd 9 EC50
  • (1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol
  • 25-Hydroxycholesterol (25OH)
  • 25-hydroxycholesterol
  • Androgen receptor
  • Cytochrome P450 125 (CYP125)
  • Cytochrome P450 142 (CYP142)
  • DNA polymerase (alpha/delta/epsilon)
  • DNA polymerase beta
  • Nuclear receptor ROR-gamma (RORC)
  • OSBP-related protein 4 (ORP4L)
  • OSBP-related protein 4 (ORP4S)
  • Oxysterols receptor LXR-alpha
  • P-glycoprotein 1
  • Sterol 14α-demethylase (CYP51)
  • Tryptophan-rich sensory protein/translocator protein (TSPO)
5 IC50 6 Kd 1 EC50 1 Other
  • (1S,2R,5S,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol
  • cholesterol
  • ATP-binding cassette sub-family G member 2
  • Aldehyde oxidase
  • Androgen receptor
  • Baculoviral IAP repeat-containing protein 2/Estrogen receptor
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Estradiol receptor beta (ERβ)
  • Estrogen receptor
  • Estrogen-Related Receptor, gamma
  • Nuclear receptor subfamily 1 group I member 2
  • Sarcoplasmic/endoplasmic reticulum calcium ATP-ase
  • UDP-glucose 4-epimerase
4 Ki 16 IC50 6 EC50
  • 4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol
  • 4-[(E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol
  • CHEMBL411
  • Diethylstilbestrol
  • Diethylstilbestrol (1)
  • Stilbestrol
  • Stilboestroform
  • Chlorite dismutase (HemQ)
  • Glutathione transferase (GST)
  • His8-Native/FLAG-Native
  • His8-Native/His8-Native
  • His8-R120A/His8-R120A
  • His8-R120Q/His8-R120Q
  • His8-S530A/FLAG-Native
  • His8-S530A/His8-S530A
  • His8-Y385F R120A/FLAG-Native
  • His8-Y385F/FLAG-Native
  • His8-Y385F/His8-Y385F
  • Tryptophan-rich sensory protein/translocator protein (TSPO)
1 IC50 12 Kd
  • 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(2+)
  • Haemin
  • Heme
  • Bile salt export pump
  • Cytochrome P450 3A
  • Gamma-aminobutyric acid receptor subunit alpha-1
  • P-glycoprotein (P-gp)
  • P-glycoprotein 1
  • P-glycoprotein 1 and 3 (MDR1a/MDR1b)
  • Peripheral-Type Benzodiazepine Receptor
  • Solute carrier family 22 member 1
  • Uridine-5'-diphosphoglucuronosyltransferase 1A1
  • Uridine-5'-diphosphoglucuronosyltransferase 1A6
  • Uridine-5'-diphosphoglucuronosyltransferase 2B10
  • Uridine-5'-diphosphoglucuronosyltransferase 2B7
4 Ki 14 IC50
  • 12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene
  • 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
  • CHEMBL655
  • Dormicum
  • Midazolam
  • Ro 21-3981
  • Adenosine receptor A3
  • Cytochrome P450 1A
  • Cytochrome P450 2B6
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
8 IC50 8 Kd
  • US9295672, (S)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol
  • Adenosine receptor A3
  • Cytochrome P450 1A
  • Cytochrome P450 2B6
  • Cytochrome P450 2C19
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
8 IC50 5 Kd
  • US9295672, (R)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol
  • CNR1
  • Cannabinoid receptor
  • Cannabinoid receptor 1
  • Cannabinoid receptor 2
  • FABP5-ANS
  • Fatty-acid amide hydrolase 1
  • Liver fatty acid binding protein (FABP1)
  • Potassium channel protein TASK-1
  • Potassium channel subfamily K member 2
  • Sterol 14α-demethylase (CYP51)
  • Transient receptor potential cation channel subfamily V member 1
  • Vanilloid receptor
71 Ki 11 IC50 1 Kd 7 EC50
  • (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide
  • AEA
  • ANANDAMIDE
  • Arachidonoyl ethanolamide
  • Arachidonoyl ethanolamide (AEA)
  • Arachidonoylethanolamide (AEA)
  • Arachidonylethanolamide
  • CHEMBL15848
  • [14C]Anandamide
  • [3H]Anandamide
  • Aurora kinase B
  • Cytochrome P450 1A
  • Cytochrome P450 1A1
  • Cytochrome P450 1B1
  • Inositol hexakisphosphate kinase 2
  • Inositol polyphosphate multikinase
  • Lysine-specific histone demethylase 1A
  • Mitogen-activated protein kinase 10
  • Mitogen-activated protein kinase 14
  • Multidrug resistance protein 1/Multidrug resistance associated protein 1
  • Multidrug resistance-associated protein 2 (MRP2)
  • alpha-Amylase
3 Ki 11 IC50 1 Other
  • 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one
  • Diosmetin
  • Diosmetin (25)
  • Alkaline phosphatase, tissue-nonspecific isozyme
  • Aminopeptidase N
  • Cathepsin D
  • Chymotrypsin
  • Ectonucleoside triphosphate diphosphohydrolase 1
  • Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
  • Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
  • Leukocyte elastase
  • Plasma kallikrein
  • Prothrombin
  • Urokinase-type plasminogen activator
  • X-linked inhibitor of apoptosis protein (XIAP)
1 Ki 6 IC50
  • 4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl-1H-pyrazole
  • N-Benzoylpyrazole deriv., 30
  • Carbonic Anhydrase III
  • Carbonic Anhydrase VA
  • Carbonic Anhydrase VB
  • Carbonic Anhydrase XIV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 13 (CA XIII)
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • Carbonic anhydrase 6 (CA-VI)
  • Carbonic anhydrase 7
  • Carbonic anhydrase 9
12 Ki
  • Grayanotoxin III (GTX3)
  • Axin-1/Glycogen synthase kinase-3 beta
  • Cyclin-Dependent Kinase 9 (CDK9)
  • Cyclin-dependent kinase 2
  • Cyclin-dependent kinase 7
  • Cyclin-dependent kinase 9
  • Glycogen Synthase Kinase 3 (GSK3)
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  • Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
  • Tyrosine-protein kinase receptor FLT3
14 IC50 3 Kd
  • CHEMBL393525
  • N'-[(1E)-{6-bromoimidazo[1,2-a]pyridin-3-yl}methylidene]-N,2-dimethyl-5-nitrobenzene-1-sulfonohydrazide
  • PIK-75, 1
  • imidazopyridine derivative, 8c
  • Phosphodiesterase 10A (PDE10A2)
  • Phosphodiesterase 11A (PDE11A)
  • Phosphodiesterase 1A
  • Phosphodiesterase 2A (PDE2A)
  • Phosphodiesterase 3 (PDE3)
  • Phosphodiesterase 6
  • Phosphodiesterase 7
  • Phosphodiesterase 8
  • Phosphodiesterase 9A (PDE9A2)
  • cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4A Isoform 4
  • cGMP-specific 3',5'-cyclic phosphodiesterase
12 IC50
  • US9493447, 1001
  • C-C chemokine receptor type 1
  • Gag-Pol polyprotein
  • Human immunodeficiency virus type 1 integrase
  • Human immunodeficiency virus type 1 reverse transcriptase
  • Integrase
  • Potassium voltage-gated channel subfamily H member 2
  • Reverse transcriptase
  • Sodium channel protein type 5 subunit alpha
  • Uridine-5'-diphosphoglucuronosyltransferase 1A1
  • Voltage-gated L-type calcium channel
  • Voltage-gated potassium channel beta subunit Mink/subunit Kv7.1
  • Voltage-gated potassium channel subunit Kv4.3
1 Ki 67 IC50
  • N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl]-5-methyl-1,3,4-oxadiazole-2-carboxamide
  • Raltegravir
  • Adenosine Phosphosulfate Reductase (APSR)
  • Beta lactamase
  • G protein signalling regulator 19
  • G2/mitotic-specific cyclin-B1
  • Indoleamine 2,3-dioxygenase
  • RGS7
  • Regulator of G-protein signaling 8
  • Toll-like receptor 9
  • WEE1 homolog (S. pombe)
  • mRNA interferase toxin, antitoxin is MazE
  • regulator of G-protein signaling 4
  • regulator of G-protein signalling 16
3 IC50 1 Kd 9 EC50
  • 2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-1-oxidopyridin-1-ium
  • NSC228155
  • cid_313619
  • 5-hydroxytryptamine receptor 1A
  • Beta-1 adrenergic receptor
  • Beta-2 adrenergic receptor
  • Beta-3 adrenergic receptor
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • D(2) dopamine receptor
  • Dipeptidyl peptidase 3
  • Liver fatty acid binding protein (rat L-FABP)
  • Multidrug resistance-associated protein 4
  • Serotonin 1B/1D receptor
13 Ki 9 IC50 12 Kd
  • 2-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide
  • Artrenolol
  • Atenolol
  • CHEMBL24
  • Tenormin
  • Tenormine
  • 10 kDa chaperonin
  • 60 kDa chaperonin
  • ADRB2
  • Beta-1 adrenergic receptor
  • Beta-2 adrenergic receptor
  • Beta-3 adrenergic receptor
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • HSP60/HSP10
  • Multidrug resistance-associated protein 4
  • Thiosulfate sulfurtransferase
8 Ki 14 IC50 13 Kd 6 EC50
  • 4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol
  • Levalbuterol
  • Proventil
  • Salbutamol
  • Salbutamol,(+/-)
  • albuterol
  • GABA receptor alpha-1/beta-3/gamma-2 subunit
  • GABA receptor alpha-2/beta-3/gamma-2 subunit
  • GABA receptor alpha-3/beta-3/gamma-2 subunit
  • GABA receptor alpha-4/beta-3/gamma-2 subunit
  • GABA receptor alpha-5/beta-3/gamma-2 subunit
  • GABA receptor alpha-6/beta-3/gamma-2 subunit
  • GABAA Receptor, alpha-1, beta-3, gamma-2
  • GABAA Receptor, alpha-2, beta-3, gamma-2
  • GABAA Receptor, alpha-3, beta-3, gamma-2
  • GABAA Receptor, alpha-4, beta-3, gamma-2
  • GABAA Receptor, alpha-5, beta-3, gamma-2
  • GABAA Receptor, alpha-6, beta-3, gamma-2
17 Ki
  • 3-({12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,10,12-pentaen-5-yl}carbonyloxy)propyl 12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,11,13-pentaene-5-carboxylate
  • CHEMBL35571
  • XLi093, 2
  • Carbonic Anhydrase III
  • Carbonic Anhydrase VA
  • Carbonic Anhydrase VB
  • Carbonic Anhydrase XIII
  • Carbonic Anhydrase XIV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • Carbonic anhydrase 6 (CA-VI)
  • Carbonic anhydrase 7
  • Carbonic anhydrase 9
12 Ki
  • EMD 486019
  • [2-(cycloheptylmethyl)-1,1-dioxo--benzothiophen-6-yl] sulfamate
  • 1,3-beta-glucan synthase component GLS2
  • Bile salt export pump
  • Cytoplasmic tyrosine-protein kinase BMX
  • Epidermal growth factor receptor
  • Nuclear receptor subfamily 1 group I member 2
  • Phosphatidylinositol 4-kinase, PI4K
  • Receptor protein-tyrosine kinase erbB-4
  • Receptor tyrosine-protein kinase erbB-2
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase ITK/TSK
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase TEC
9 IC50 8 Kd 1 EC50
  • US10457647, Example 6
  • US9512084, 6
  • 1,3-beta-glucan synthase component GLS2
  • Cytochrome P450 4B1
  • JAK1 (aa 866-1154)
  • JAK2 (aa 808-1132)
  • JAK2 (aa 831-1132)
  • JAK3 (aa 781-1124)
  • JAK3 (aa 811-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK1 (aa 866-1154)
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
16 IC50
  • (2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl)amino] pyrimidin-4- yl}-1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)propanamide
  • US10167276, Example 32
  • US10654835, Example 32
  • US9714236, 32
  • 72 kDa type IV collagenase
  • ADAM17
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase 10
  • Matrix metalloproteinase 15
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-14 (MMP14)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
15 Ki 2 IC50
  • (3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]methyl}benzene)oxane-3,4-dicarboxamide
  • pyrazolopyridine, 49
  • Carbonic Anhydrase III
  • Carbonic Anhydrase VA
  • Carbonic Anhydrase VB
  • Carbonic Anhydrase XIII
  • Carbonic Anhydrase XIV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • Carbonic anhydrase 6 (CA-VI)
  • Carbonic anhydrase 7
  • Carbonic anhydrase 9
12 Ki
  • 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide
  • TRICHLORMETHIAZIDE
  • trichloromethiazide, 6
  • 3',5'-cyclic phosphodiesterase
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
  • Homo sapiens phosphodiesterase 2A (PDE2A)
  • Phosphodiesterase 11A
  • Phosphodiesterase 2 and 5 (PDE2 and PDE5)
  • Phosphodiesterase 3 and 5 (PDE3 and PDE5)
  • Phosphodiesterase 6C (PDE6C)
  • Phosphodiesterase 7
  • Phosphodiesterase 8
  • Potassium voltage-gated channel subfamily H member 2
  • cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
14 IC50 1 EC50
  • 6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)methyl)-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5 (6H)-one
  • US10092575, Example 141
  • US10376514, Example 141
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • Bile salt export pump
  • Bile salt export pump (BSEP)
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Monoamine Oxidase Type B (MAO-B)
  • Monoamine oxidase
  • Multidrug resistance-associated protein 4
  • Sodium-dependent dopamine transporter
  • Sodium-dependent noradrenaline transporter
  • Sodium-dependent serotonin transporter
3 Ki 136 IC50
  • CHEMBL92401
  • Euphozid
  • Iprazid
  • Iproniazid
  • 3',5'-cyclic phosphodiesterase
  • Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
  • Homo sapiens phosphodiesterase 2A (PDE2A)
  • Phosphodiesterase 11A
  • Phosphodiesterase 2 and 5 (PDE2 and PDE5)
  • Phosphodiesterase 3 and 5 (PDE3 and PDE5)
  • Phosphodiesterase 6C (PDE6C)
  • Phosphodiesterase 7
  • Phosphodiesterase 8
  • Potassium voltage-gated channel subfamily H member 2
  • cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
14 IC50
  • US10105367, Example 82
  • US10376514, Example 82
  • DNA dC->dU-editing enzyme APOBEC-3G
  • Gag-Pol polyprotein
  • Glucose 6-phosphate dehydrogenase (G6PD)
  • MPI protein
  • Runt-Related Transcription Factor 1 Isoform AML1C
  • Voltage-gated calcium channel subunit alpha Cav2.2
  • diphosphomevalonate decarboxylase
  • glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
  • hexokinase
  • mevalonate kinase
  • phosphomannomutase 2
  • probable DNA dC->dU-editing enzyme APOBEC-3A
18 IC50
  • 2-[2-(3-keto-1,2-benzothiazol-2-yl)thiazol-4-yl]acetic acid ethyl ester
  • 2-[2-(3-oxo-1,2-benzothiazol-2-yl)-4-thiazolyl]acetic acid ethyl ester
  • MLS000082162
  • SMR000060804
  • cid_2328662
  • ethyl 2-[2-(3-oxidanylidene-1,2-benzothiazol-2-yl)-1,3-thiazol-4-yl]ethanoate
  • ethyl 2-[2-(3-oxo-1,2-benzothiazol-2-yl)-1,3-thiazol-4-yl]acetate
  • 5-hydroxytryptamine receptor 1A
  • Apoptotic peptidase activating factor 1
  • Caspase-3
  • Caspase-9
  • Heat shock protein HSP 90-alpha
  • SUMO-1-specific protease
  • SUMO-activating enzyme
  • SUMO/sentrin specific peptidase family member 8
  • SUMO1 activating enzyme subunit 1
  • Valosin-containing protein
  • tyrosyl-DNA phosphodiesterase 2
  • ubiquitin-conjugating enzyme E2I
14 IC50 1 EC50
  • MLS000068755
  • N-(1-butyl-3-cyano-2-pyrrolo[3,2-b]quinoxalinyl)-2-chlorobenzamide
  • N-(1-butyl-3-cyano-pyrrolo[3,2-b]quinoxalin-2-yl)-2-chloranyl-benzamide
  • N-(1-butyl-3-cyano-pyrrolo[3,2-b]quinoxalin-2-yl)-2-chloro-benzamide
  • N-(1-butyl-3-cyanopyrrolo[3,2-b]quinoxalin-2-yl)-2-chlorobenzamide
  • SMR000039762
  • US9045483, 2
  • cid_658797
  • 5-hydroxytryptamine receptor 1A
  • Apoptotic peptidase activating factor 1
  • Bcl-2-related protein A1
  • Caspase-3
  • Caspase-9
  • Dual Specificity Protein Phosphatase 1
  • MKP-3
  • MPI protein
  • SUMO-1-specific protease
  • SUMO/sentrin specific peptidase family member 8
  • diphosphomevalonate decarboxylase
  • tyrosyl-DNA phosphodiesterase 2
18 IC50 2 EC50
  • MLS000079925
  • N-[3-cyano-1-(4-methoxyphenyl)-2-pyrrolo[3,2-b]quinoxalinyl]-2-furancarboxamide
  • N-[3-cyano-1-(4-methoxyphenyl)pyrrolo[3,2-b]quinoxalin-2-yl]-2-furamide
  • N-[3-cyano-1-(4-methoxyphenyl)pyrrolo[3,2-b]quinoxalin-2-yl]furan-2-carboxamide
  • SMR000039887
  • cid_658939
  • 5-hydroxytryptamine receptor 1A
  • Bcl-2-like protein 11
  • DNA damage-inducible transcript 3 protein
  • DNA recombination protein RecA
  • Nuclear receptor ROR-alpha
  • STAT3
  • Serotonin (5-HT) receptor
  • Sphingosine 1-phosphate receptor 3
  • Steroidogenic Factor 1
  • Transcription Factor STAT1
  • Tyrosine-protein kinase JAK2
  • XBP1
11 IC50 3 EC50
  • 4-(2-furanyl)-2-methylsulfonyl-6-(trifluoromethyl)pyrimidine
  • 4-(2-furyl)-2-(methylsulfonyl)-6-(trifluoromethyl)pyrimidine
  • 4-(2-furyl)-2-mesyl-6-(trifluoromethyl)pyrimidine
  • 4-(furan-2-yl)-2-methylsulfonyl-6-(trifluoromethyl)pyrimidine
  • MLS000044646
  • SMR000022590
  • cid_3237865
  • 5-hydroxytryptamine receptor 1A
  • Angiotensin II receptor
  • Apelin receptor
  • Beta lactamase
  • Hsf1 protein
  • LDL-associated phospholipase A2
  • Nuclear receptor ROR-alpha
  • Serine/threonine-protein kinase RIPK2
  • Serotonin (5-HT) receptor
  • Sphingosine 1-phosphate receptor 3
  • Steroidogenic Factor 1
  • streptokinase A precursor
12 IC50 2 EC50
  • MLS000062611
  • N-(6-methoxy-8-quinolinyl)-4-methylbenzenesulfonamide
  • N-(6-methoxy-8-quinolyl)-4-methyl-benzenesulfonamide
  • N-(6-methoxyquinolin-8-yl)-4-methyl-benzenesulfonamide
  • N-(6-methoxyquinolin-8-yl)-4-methylbenzenesulfonamide
  • SMR000071147
  • cid_130606
  • Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Bcl2-L-10) (Anti-apoptotic protein NrH).
  • Bcl-2-related protein A1
  • Dual Specificity Protein Phosphatase 1
  • Dual specificity phosphatase Cdc25B
  • Gag-Pol polyprotein
  • Heat Shock 70kDa Protein 1
  • Hematopoietic protein-tyrosine phosphatase (HEPTP)
  • MKP-3
  • diphosphomevalonate decarboxylase
  • glutathione S-transferase
  • heat shock 70kDa protein 8 isoform 1
  • nuclear receptor subfamily 4, group A, member 1
27 IC50 3 EC50
  • MLS000050353
  • N-(2,3-di-2-furyl-6-quinoxalinyl)-1-azepanecarboxamide
  • N-[2,3-bis(2-furanyl)-6-quinoxalinyl]-1-azepanecarboxamide
  • N-[2,3-bis(2-furyl)quinoxalin-6-yl]azepane-1-carboxamide
  • N-[2,3-bis(furan-2-yl)quinoxalin-6-yl]azepane-1-carboxamide
  • SMR000077614
  • cid_2214811
  • CaM-kinase kinase beta
  • Dual specificity protein kinase CLK1/CLK4
  • Dual specificity protein kinase CLK2
  • Dual specificity protein kinase TTK
  • Dual specificity tyrosine-phosphorylation-regulated kinase 1B
  • Dual specificty protein kinase CLK1
  • Dual-specificity tyrosine-phosphorylation regulated kinase 1A
  • Dual-specificity tyrosine-phosphorylation regulated kinase 3
  • Melanin-concentrating hormone receptor 2/HERG
  • Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma
  • Phosphorylase kinase
  • c-Jun N-terminal kinase, JNK
19 IC50
  • 4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2- ylamino)-3-methoxy-N- methylbenzamide
  • US9623028, Compound 38
  • Acetylcholinesterase
  • Cholinesterases
  • Cyclin-dependent kinase 2
  • Heat shock protein HSP 90-alpha
  • Hematopoietic protein-tyrosine phosphatase (HEPTP)
  • MSRA protein
  • POsterior Segregation family member (pos-1)
  • RecName: Full=Zinc finger protein mex-5
  • Sialidase 2
  • Thioredoxin reductase 1, cytoplasmic
  • Thioredoxin reductase 2, mitochondrial
  • plectin 1
13 IC50 1 Kd 2 EC50
  • 4,5-bis(oxidanyl)-9,10-bis(oxidanylidene)anthracene-2-carboxylic acid
  • 4,5-dihydroxy-9,10-diketo-anthracene-2-carboxylic acid
  • 4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid
  • 4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid
  • MLS000069639
  • RHEIN
  • SMR000058210
  • US9238626, Rhein
  • cid_10168
  • Apoptosis regulator Bcl-2
  • BCL-W
  • BZLF2
  • Heat shock protein HSP 90-alpha
  • Isoform Bcl-X(L)
  • LANA
  • Mitogen-activated protein kinase 10
  • Mitogen-activated protein kinase kinase kinase kinase 2
  • POsterior Segregation family member (pos-1)
  • RecName: Full=Zinc finger protein mex-5
  • glutathione S-transferase
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
4 IC50 9 EC50
  • MLS000080234
  • SMR000040438
  • cid_659413
  • 12-Lipoxygenase (12-LOX)
  • 15-Lipoxygenase-2 (15-LOX-2)
  • Arachidonate 15-lipoxygenase
  • Arachidonate 5-lipoxygenase
  • Botulinum neurotoxin type A
  • Cystic fibrosis transmembrane conductance regulator
  • Heat shock protein HSP 90-alpha
  • Integrase
  • Kappa-type opioid receptor
  • MEP2
  • Nuclear receptor subfamily 1 group I member 2
  • citrate synthase 2
10 IC50 4 EC50
  • AS-229
  • CHLOROXINE
  • cid_2722
  • Apoptosis regulator Bcl-2
  • Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Bcl2-L-10) (Anti-apoptotic protein NrH).
  • BCL-W
  • Bcl-2-related protein A1
  • Focal adhesion kinase 1
  • Hematopoietic protein-tyrosine phosphatase (HEPTP)
  • Isoform Bcl-X(L)
  • NS3
  • PTK2B protein tyrosine kinase 2 beta (PTK2B)
  • core protein
  • eukaryotic translation initiation factor 4 gamma, 1 isoform 4
  • nuclear receptor subfamily 4, group A, member 1
10 IC50 5 EC50
  • MLS000534769
  • N-(4-acetylphenyl)-2,3-bis(2-furanyl)-6-quinoxalinecarboxamide
  • N-(4-acetylphenyl)-2,3-bis(2-furyl)quinoxaline-6-carboxamide
  • N-(4-acetylphenyl)-2,3-bis(furan-2-yl)quinoxaline-6-carboxamide
  • N-(4-acetylphenyl)-2,3-di-2-furyl-6-quinoxalinecarboxamide
  • N-(4-ethanoylphenyl)-2,3-bis(furan-2-yl)quinoxaline-6-carboxamide
  • SMR000142225
  • cid_1331726
  • Bcl-2-related protein A1
  • DNA dC->dU-editing enzyme APOBEC-3G
  • Gag-Pol polyprotein
  • Hexokinase type I
  • Low molecular weight phosphotyrosine protein phosphatase
  • MPI protein
  • Voltage-gated calcium channel subunit alpha Cav2.2
  • eukaryotic translation initiation factor 4 gamma, 1 isoform 4
  • neuronal munc18-1 binding protein
  • phosphomannomutase 2
  • probable DNA dC->dU-editing enzyme APOBEC-3A
  • putative hexokinase HKDC1
11 IC50 3 EC50
  • (4-chlorodithiazol-5-ylidene)-(3,4,5-trimethoxyphenyl)amine
  • 4-chloranyl-N-(3,4,5-trimethoxyphenyl)-1,2,3-dithiazol-5-imine
  • 4-chloro-N-(3,4,5-trimethoxyphenyl)-5-dithiazolimine
  • 4-chloro-N-(3,4,5-trimethoxyphenyl)dithiazol-5-imine
  • MLS000090424
  • N-[(5Z)-4-chloro-5H-1,2,3-dithiazol-5-ylidene]-3,4,5-trimethoxyaniline
  • SMR000025034
  • cid_715715
  • Apoptosis regulator Bcl-2
  • Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Bcl2-L-10) (Anti-apoptotic protein NrH).
  • BCL-W
  • Bcl-2-related protein A1
  • Dual Specificity Protein Phosphatase 1
  • Dual specificity phosphatase Cdc25B
  • Hematopoietic protein-tyrosine phosphatase (HEPTP)
  • Induced myeloid leukemia cell differentiation protein Mcl-1
  • MKP-3
  • SUMO1 activating enzyme subunit 1
  • nuclear receptor subfamily 4, group A, member 1
  • ubiquitin-conjugating enzyme E2I
14 IC50 5 EC50
  • 2,3-bis(2-furanyl)-N-phenyl-6-quinoxalinecarboxamide
  • 2,3-bis(2-furyl)-N-phenyl-quinoxaline-6-carboxamide
  • 2,3-bis(furan-2-yl)-N-phenyl-quinoxaline-6-carboxamide
  • 2,3-bis(furan-2-yl)-N-phenylquinoxaline-6-carboxamide
  • 2,3-di-2-furyl-N-phenyl-6-quinoxalinecarboxamide
  • MLS000050204
  • SMR000077343
  • cid_2213073
  • Carbonic Anhydrase III
  • Carbonic Anhydrase VA
  • Carbonic Anhydrase VB
  • Carbonic Anhydrase XIII
  • Carbonic Anhydrase XIV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • Carbonic anhydrase 6 (CA-VI)
  • Carbonic anhydrase 7
  • Carbonic anhydrase 9
18 Ki
  • CHEMBL24261
  • aliphatic sulfamate, 1
  • Carbonic Anhydrase III
  • Carbonic Anhydrase VA
  • Carbonic Anhydrase VB
  • Carbonic Anhydrase XIII
  • Carbonic Anhydrase XIV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • Carbonic anhydrase 6 (CA-VI)
  • Carbonic anhydrase 7
  • Carbonic anhydrase 9
18 Ki
  • CHEMBL153094
  • aliphatic sulfamate, 2
  • Carbonic Anhydrase III
  • Carbonic Anhydrase VA
  • Carbonic Anhydrase VB
  • Carbonic Anhydrase XIII
  • Carbonic Anhydrase XIV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • Carbonic anhydrase 6 (CA-VI)
  • Carbonic anhydrase 7
  • Carbonic anhydrase 9
17 Ki
  • CHEMBL182455
  • bis-sulfamate, 3
  • Carbonic Anhydrase III
  • Carbonic Anhydrase VA
  • Carbonic Anhydrase VB
  • Carbonic Anhydrase XIII
  • Carbonic Anhydrase XIV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • Carbonic anhydrase 6 (CA-VI)
  • Carbonic anhydrase 7
  • Carbonic anhydrase 9
15 Ki
  • CHEMBL171476
  • bis-sulfamate, 4
  • 3C-like proteinase
  • Cytochrome P450 3A
  • PKC alpha and beta-2
  • Protein Kinase C, eta
  • Protein kinase C (PKC)
  • Protein kinase C alpha type
  • Protein kinase C delta type
  • Protein kinase C theta type
  • Protein kinase C, PKC; classical/novel
  • Protein kinase C, epsilon
  • Protein kinase C, eta
  • Serine/threonine-protein kinase pim-1
1 Ki 21 IC50 1 EC50
  • AEB071
  • Sotrastaurin
  • med.21724, Compound 190
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 1B
  • 5-hydroxytryptamine receptor 1D
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 6
  • 5-hydroxytryptamine receptor 7
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • HTR5A
  • Serotonin (5-HT) receptor
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
37 Ki
  • CHEMBL76237
  • MS-245
  • Cyclin-dependent kinase 4
  • Epidermal growth factor receptor
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • Insulin receptor
  • Mitogen-activated protein kinase; ERK1/ERK2
  • PDGFR-beta/Platelet-derived growth factor receptor alpha
  • Platelet-derived growth factor receptor beta
  • Protein kinase C (PKC)
  • Proto-oncogene tyrosine-protein kinase Src
19 IC50
  • 1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
  • 6-arylpyrido[2,3-d]pyrimidine deriv. 1
  • CHEMBL57366
  • PD089828
  • Cytochrome P450 1A
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • Potassium voltage-gated channel subfamily H member 2
  • Sodium channel alpha subunit
  • Sodium channel alpha subunits; brain (Types I, II, III)
  • Sodium channel protein type 5 subunit alpha
  • Sodium channel protein type 8 subunit alpha
  • Sodium channel protein type 9 subunit alpha
  • Sodium channel protein type IX alpha subunit
  • Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)
17 IC50
  • 1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphenylyl)-N-3-isoxazolyl-6-isoquinolinesulfonamide
  • US9776995, Example 115
  • Caspase-3
  • Focal adhesion kinase 1
  • MPI protein
  • MSRA protein
  • PTK2B protein tyrosine kinase 2 beta (PTK2B)
  • SUMO-1-specific protease
  • SUMO/sentrin specific peptidase family member 8
  • Serine/threonine-protein kinase PLK1
  • Trypanosoma brucei RNA editing ligase 1
  • protein artemis isoform a
  • putative hexokinase HKDC1
  • tyrosyl-DNA phosphodiesterase 2
12 IC50 3 EC50
  • 2-methyl-3-(phenylcarbonyl)benzo[g][1]benzofuran-4,5-dione
  • 3-Benzoyl-2-methyl-naphtho[1,2-b]furan-4,5-dione
  • 3-benzoyl-2-methyl-benzo[g]benzofuran-4,5-quinone
  • 3-benzoyl-2-methylbenzo[g][1]benzofuran-4,5-dione
  • 3-benzoyl-2-methylbenzo[g]benzofuran-4,5-dione
  • MLS000554105
  • SMR000146422
  • cid_3816369
  • Coagulation factor IX
  • Coagulation factor X
  • Coagulation factor XI
  • Coagulation factor XII
  • Kallikrein 1
  • Plasma kallikrein
  • Plasminogen
  • Prothrombin
  • Thrombin and coagulation factor VII
  • Tissue-type plasminogen activator
  • Urokinase-type plasminogen activator/surface receptor
  • Vitamin K-dependent protein C
13 Ki
  • (S,E)-4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid, TFA salt
  • US10208021, Example 184
  • Epidermal growth factor receptor
  • Epidermal growth factor receptor erbB1
  • Fructose-1,6-bisphosphatase
  • Fructose-1,6-bisphosphatase 1 (FBPase)
  • MAP kinase-interacting serine/threonine-protein kinase 1
  • Mitogen-activated protein kinase 14
  • PDGFR-beta/Platelet-derived growth factor receptor alpha
  • Protein kinase C alpha type
  • Proto-oncogene tyrosine-protein kinase Src
  • Tyrosine- and threonine-specific cdc2-inhibitory kinase
  • Tyrosine-protein kinase ABL
  • Tyrosine-protein kinase Lck
5 Ki 24 IC50
  • CHEMBL540068
  • CHEMBL7917
  • N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine
  • PD153035 Analog 31
  • Apoptotic peptidase activating factor 1
  • Caspase-3
  • Caspase-9
  • Dual Specificity Protein Phosphatase 1
  • MKP-3
  • SUMO-1-specific protease
  • SUMO/sentrin specific peptidase family member 8
  • Zinc aminopeptidase
  • nuclear receptor corepressor 2 isoform 2
  • photoreceptor-specific nuclear receptor
  • plectin 1
  • tyrosyl-DNA phosphodiesterase 2
20 IC50
  • 5-bromanyl-N-(3-cyano-1-phenyl-pyrrolo[3,2-b]quinoxalin-2-yl)furan-2-carboxamide
  • 5-bromo-N-(3-cyano-1-phenyl-2-pyrrolo[3,2-b]quinoxalinyl)-2-furancarboxamide
  • 5-bromo-N-(3-cyano-1-phenyl-pyrrolo[3,2-b]quinoxalin-2-yl)-2-furamide
  • 5-bromo-N-(3-cyano-1-phenylpyrrolo[3,2-b]quinoxalin-2-yl)furan-2-carboxamide
  • MLS000068756
  • SMR000039905
  • cid_658921
  • Apoptotic peptidase activating factor 1
  • Caspase-3
  • Caspase-9
  • DNA recombination protein RecA
  • Dual Specificity Protein Phosphatase 1
  • Intestinal alkaline phosphatase
  • MKP-3
  • SUMO-1-specific protease
  • SUMO/sentrin specific peptidase family member 8
  • SUMO1 activating enzyme subunit 1
  • mothers against decapentaplegic homolog 3
  • ubiquitin-conjugating enzyme E2I
17 IC50 2 EC50
  • (7-chloro-5-pyrrolidino-benzofurazan-4-yl)amine
  • 7-chloranyl-5-pyrrolidin-1-yl-2,1,3-benzoxadiazol-4-amine
  • 7-chloro-5-(1-pyrrolidinyl)-2,1,3-benzoxadiazol-4-amine
  • 7-chloro-5-pyrrolidin-1-yl-2,1,3-benzoxadiazol-4-amine
  • MLS000042514
  • SMR000048561
  • cid_667215
  • α-Carbonic anhydrase (αCA)
  • β-Carbonic anhydrase (βCA)
  • Alpha-carbonic anhydrase
  • Astrosclerin-3
  • Beta-carbonic anhydrase
  • Carbonic Anhydrase VA
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • Carbonic anhydrase 9
  • Gamma-carbonic anhydrase
  • Sodium/iodide cotransporter
27 Ki 1 IC50
2 ΔG°
  • perchlorate
  • sodium perchlorate
  • Cereblon/Histone deacetylase 6
  • Histone deacetylase
  • Histone deacetylase 1
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
  • NAD-dependent protein deacetylase sirtuin-5 (SIRT5)
  • Sigma non-opioid intracellular receptor 1
2 Ki 10 IC50
1 ΔG°
  • 4-phenylbutanoate
  • Angiotensin II receptor
  • Apelin receptor
  • DNA damage-inducible transcript 3 protein
  • G2/mitotic-specific cyclin-B1
  • Hsf1 protein
  • LAP4
  • Nuclear receptor ROR-alpha
  • RPL19A
  • Sphingosine 1-phosphate receptor 2
  • Steroidogenic Factor 1
  • WEE1 homolog (S. pombe)
  • XBP1
11 IC50 5 EC50
  • (1Z,3Z)-1,4-bis(butylsulfonyl)buta-1,3-diene
  • MLS000085704
  • SMR000020833
  • cid_5286934
  • Adrenaline alpha1
  • Adrenaline alpha2
  • Adrenergic Alpha
  • Alkaline phosphatase placental-like
  • Alpha-1 adrenergic receptor
  • Ribosyldihydronicotinamide dehydrogenase [quinone]
  • Solute carrier family 22 member 1
  • Solute carrier family 22 member 2
  • Solute carrier family 22 member 3
  • Sphingosine 1-phosphate receptor 2
  • eukaryotic translation initiation factor 4 gamma, 1 isoform 4
  • streptokinase A precursor
5 Ki 10 IC50 2 EC50
  • (2E)-1-ethyl-2-[(1-ethyl-2-quinolin-1-iumyl)methylidene]quinoline;chloride
  • (2E)-1-ethyl-2-[(1-ethylquinolin-1-ium-2-yl)methylene]quinoline;chloride
  • (2E)-1-ethyl-2-[(1-ethylquinolin-1-ium-2-yl)methylidene]quinoline;chloride
  • 1-ethyl-2-[(1-ethyl-2(1H)-quinolinylidene)methyl]quinolinium chloride
  • CHEMBL1197556
  • MLS000532635
  • SMR000137574
  • cid_5717105
  • Bcl-2-like protein 1
  • Bfl-1
  • Ephrin type-B receptor 4
  • Estradiol receptor beta (ERβ)
  • Hematopoietic protein-tyrosine phosphatase (HEPTP)
  • Homo sapiens huntingtin (HTT), mRNA
  • Induced myeloid leukemia cell differentiation protein Mcl-1
  • Kallikrein 5
  • MKP-3
  • RNA polymerase beta subunit (EC 2.7.7.6)
  • large T antigen
  • ubiquitin-conjugating enzyme E2 N
13 IC50
  • 2,3,5,6-tetrakis(2-furanyl)pyrazine
  • 2,3,5,6-tetrakis(2-furyl)pyrazine
  • 2,3,5,6-tetrakis(furan-2-yl)pyrazine
  • MLS000055488
  • SMR000065994
  • cid_854635
  • Cereblon/Histone deacetylase 1
  • Cereblon/Histone deacetylase 6
  • Histone deacetylase 1
  • Histone deacetylase 10
  • Histone deacetylase 11
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
16 IC50
  • 4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxybenzamide
  • US10456394, Example 2
  • Alkaline phosphatase, tissue-nonspecific isozyme
  • Beta lactamase
  • DNA dC->dU-editing enzyme APOBEC-3G
  • MPI protein
  • MSRA protein
  • Serine/threonine-protein kinase RIPK2
  • Toll-like receptor 9
  • glucose-6-phosphate dehydrogenase
  • hexokinase
  • phosphatase, orphan 1
  • phosphomannomutase 2
  • probable DNA dC->dU-editing enzyme APOBEC-3A
12 IC50 1 EC50
  • 5-fluoranyl-2-phenyl-1,2-benzothiazol-3-one
  • 5-fluoro-2-phenyl-1,2-benzothiazol-3-one
  • ML089
  • MLS-0315921.0001
  • cid_22416235
  • 26S Proteasome regulatory subunit Rpn11 (Rpn11)
  • BZLF2
  • Dual specificity protein phosphatase (VHR)
  • Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
  • Hematopoietic protein-tyrosine phosphatase (HEPTP)
  • Induced myeloid leukemia cell differentiation protein Mcl-1
  • MKP-3
  • NS3
  • Thrombin
  • Voltage-gated calcium channel subunit alpha Cav2.2
  • eukaryotic translation initiation factor 4 gamma, 1 isoform 4
  • neuronal munc18-1 binding protein
18 IC50
  • MLS-0266887.0001
  • cid_2545524
  • Bile salt export pump
  • MCOLN3 protein
  • Muscarinic acetylcholine receptor
  • Muscarinic acetylcholine receptor M1
  • Muscarinic acetylcholine receptor M2
  • Muscarinic acetylcholine receptor M2 and M5
  • Muscarinic acetylcholine receptor M3
  • Muscarinic acetylcholine receptor M4
  • Muscarinic acetylcholine receptor M5
  • Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit
  • Reverse transcriptase
  • transient receptor potential cation channel, subfamily N, member 1
32 Ki 46 IC50 14 EC50
  • 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid methyl ester;hydrobromide
  • ARECOLINE
  • ARECOLINE HYDROBROMIDE
  • MLS000028840
  • SMR000058258
  • arecoline;hydrobromide
  • cid_9301
  • methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate;hydrobromide
  • DNA dC->dU-editing enzyme APOBEC-3G
  • G protein signalling regulator 19
  • Oxytocin receptor
  • RGS7
  • Regulator of G-protein signaling 8
  • Vasopressin V1a receptor
  • Voltage-gated calcium channel subunit alpha Cav2.2
  • eukaryotic translation initiation factor 4 gamma, 1 isoform 4
  • neuronal munc18-1 binding protein
  • probable DNA dC->dU-editing enzyme APOBEC-3A
  • regulator of G-protein signaling 4
  • regulator of G-protein signalling 16
4 Ki 5 IC50 12 EC50
  • (4-chlorodithiazol-5-ylidene)-(4-chloro-2-methyl-phenyl)amine
  • 4-chloranyl-N-(4-chloranyl-2-methyl-phenyl)-1,2,3-dithiazol-5-imine
  • 4-chloro-N-(4-chloro-2-methylphenyl)-5-dithiazolimine
  • 4-chloro-N-(4-chloro-2-methylphenyl)dithiazol-5-imine
  • 4-chloro-N-(4-chloro-5H-1,2,3-dithiazol-5-yliden)-2-methylaniline
  • MLS000539990
  • SMR000125448
  • cid_1471255
  • Estradiol receptor beta (ERβ)
  • Histone deacetylase 1
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8 (HDAC8)
  • Histone deacetylase 9
  • Hsf1 protein
  • TPA: Essential protein of the mitochondrial intermembrane space
  • neutrophil cytosolic factor 1
11 IC50 1 EC50
  • 5-chloranyl-7-[(4-ethylpiperazin-1-yl)-pyridin-3-yl-methyl]quinolin-8-ol
  • 5-chloro-7-[(4-ethyl-1-piperazinyl)-(3-pyridinyl)methyl]-8-quinolinol
  • 5-chloro-7-[(4-ethylpiperazin-1-yl)-pyridin-3-ylmethyl]quinolin-8-ol
  • 5-chloro-7-[(4-ethylpiperazino)-(3-pyridyl)methyl]quinolin-8-ol
  • BRD4354
  • MLS000564806
  • SMR000151966
  • cid_3516032
  • Adenosine receptor
  • BHE
  • Mas-related G protein-coupled receptor X2 (MRGPRX2)
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Prothrombin
  • Substance K
  • Substance P
  • TACR2
  • TACR3
29 Ki 25 IC50 14 EC50
  • (SP)Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
  • Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2
  • Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
  • Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2(Substance P)
  • Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.(Substance P)
  • Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-amine
  • ArgProLysProGlnGlnPhePheGlyLeuMet
  • CHEMBL235363
  • H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-D-Phe-Gly-Leu-Met-NH2
  • H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2(Substance P)
  • Substance P
  • Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2)
  • Substance P analogue
  • tachykinin substance P (SP)
  • Delta-type opioid receptor
  • Kappa-type opioid receptor
  • Mu opioid receptor-like OR2
  • Mu-type opioid receptor
  • Nociceptin/Orphanin FQ, NOP receptor
  • OPRD1
  • Opioid receptor
  • Opioid receptor homologue
  • Opioid receptor, delta 1b
  • Opioid receptors; mu & delta
  • Opioid receptors; mu and delta
  • Proenkephalin B
53 Ki 16 IC50 1 Kd 4 EC50
  • (S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid
  • ([Leu]-enkephalin)2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid
  • (enkephalin)2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid
  • 2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-1-oxo-3-phenyl-propylamino]-4-methyl-pentanoic acid
  • 2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid
  • 2-[1-[1-amino-2-(4-hydroxyphenyl)-(1S)-ethylcarboxamidomethylcarboxamidomethylcarboxamido]-2-phenyl-(1S)-ethylcarboxamido]-4-methyl-(2S)-pentanoic acid
  • 2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid
  • 2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid(Enkephalin)
  • 2-{1-[1-amino-2-(4-hydroxyphenyl)ethylcarboxamidomethylcarboxamidomethylcarboxamido]-2-phenylethylcarboxamido}-4-methylpentanoic acid
  • CHEMBL8234
  • ENKEPHALIN
  • Leu-ENKEPHALIN
  • Leu5-Enkephalin
  • Tyr-Gly-Gly-Phe-Leu-OH
  • Cholecystokinin receptor
  • GABA A Alpha2Beta1Gamma2
  • GABA A receptor alpha-3/beta-2/gamma-2
  • GABA A receptor alpha-6/beta-2/gamma-2
  • GABA receptor alpha-1/beta-3/gamma-2 subunit
  • GABA receptor alpha-2/beta-3/gamma-2 subunit
  • GABA receptor alpha-3/beta-3/gamma-2 subunit
  • GABA receptor alpha-5/beta-3/gamma-2 subunit
  • GABA receptor alpha-6/beta-3/gamma-2 subunit
  • Gamma-aminobutyric acid receptor subunit alpha-1
  • Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A))
  • Platelet activating factor receptor
17 Ki 3 IC50 2 Kd
  • 8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
  • CHEMBL646
  • Halcion
  • TRIAZOLAM
  • 5-hydroxytryptamine receptor 1A
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • Beta-1 adrenergic receptor
  • Beta-2 adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • Serotonin (5-HT) receptor
  • Serotonin 1 (5-HT1) receptor
  • Serotonin 1B/1D receptor
  • Serotonin 2 (5-HT2) receptor
  • Serotonin 3a (5-HT3a)/3b (5-HT3b)/3c (5-HT3c)/3d (5-HT3d)/3e (5-HT3e) receptor
  • Sigma non-opioid intracellular receptor 1
19 Ki 2 IC50
  • 1-Phenyl-piperazine
  • CHEMBL9434
  • PHENYLPIPERAZINE
  • 5-hydroxytryptamine receptor 1A
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • Alpha-1A adrenergic receptor
  • Beta-1 adrenergic receptor
  • Beta-2 adrenergic receptor
  • Cerebral cortex alpha adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • Serotonin 1 (5-HT1) receptor
  • Serotonin 1B/1D receptor
  • Serotonin 2 (5-HT2) receptor
  • adrenergic Alpha2
11 Ki 2 IC50
  • 1-(2-Chloro-phenyl)-piperazine
  • CHEMBL9841
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2C
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • Alpha-2C adrenergic receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • Dopamine receptor
  • Histamine H1 receptor
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
  • Sigma non-opioid intracellular receptor 1
15 Ki 3 IC50
  • 1-(4-Fluoro-phenyl)-4-(4-pyrimidin-2-yl-piperazin-1-yl)-butan-1-one
  • 4-[4-(2-Pyrimidine)piperazin-1-yl]-1-(4-fluorophenyl)-butan-1-one
  • CHEMBL140872
  • β-Carbonic anhydrase 2 (CA 2)
  • β-Carbonic anhydrase 3 (CA 3)
  • Betaine transporter
  • Carbonic Anhydrase (mtCA 1)
  • GABA transporter
  • GABA transporter 1
  • GABA transporter 2
  • GABA transporter 3
  • GABA-B receptor 1/2
  • Gamma-aminobutyric acid type B receptor subunit 1
  • Sodium- and chloride-dependent GABA transporter 1
  • Sodium- and chloride-dependent betaine transporter
5 Ki 18 IC50
  • (RS)-nipecotic acid
  • CHEMBL277498
  • Nipecotic
  • Piperidine-3-carboxylic acid
  • Piperidine-3-carboxylic acid (6)
  • Piperidine-3-carboxylic acid(nipecotic acid)
  • GRIA3
  • GRM7
  • GRM8
  • Glucosamine-6- Phosphate Synthase
  • Metabotropic glutamate receptor 1
  • Metabotropic glutamate receptor 2
  • Metabotropic glutamate receptor 4 (mGlu4)
  • Metabotropic glutamate receptor 4 (mGluR4)
  • Metabotropic glutamate receptor 5
  • Metabotropic glutamate receptor 6
  • Metabotropic glutamate receptor 6 (mGlu6)
  • Metabotropic glutamate receptor 8 (mGlu8)
14 Ki 2 IC50 3 EC50
  • 2-Amino-4-phosphono-butyric acid
  • 2-Amino-4-phosphono-butyric acid (AP4)
  • 4-Amino Phosphonobutyrate
  • CHEMBL285843
  • GlcN-6-P synthase inhibitor, 1 (racemic mixture)
  • L-AP4
  • 20S proteasome
  • 20S proteasome chymotrypsin-like
  • 26S proteosome
  • Proteasome Macropain subunit
  • Proteasome component C5
  • Proteasome subunit beta type-1
  • Proteasome subunit beta type-1/beta type-5
  • Proteasome subunit beta type-10
  • Proteasome subunit beta type-2
  • Proteasome subunit beta type-5
  • Proteasome subunit beta type-8
  • Proteasome subunit beta type-9
48 IC50
  • CHEMBL3237875
  • 5-hydroxytryptamine receptor 2A
  • ADRA1B
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • Alpha-1D adrenergic receptor
  • Cerebral cortex alpha adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • D(4) dopamine receptor
  • DRD2
  • Histamine H1 receptor
  • Serotonin 2 (5-HT2) receptor
20 Ki 7 IC50
  • 1-(8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-4-methyl-piperazine
  • CHEMBL64875
  • OCTOCLOTHEPIN-R
  • Acetylcholinesterase
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Cholecystokinin receptor
  • Cholinesterase
  • GABA receptor alpha-1/beta-3/gamma-2 subunit
  • GABA receptor alpha-2/beta-3/gamma-2 subunit
  • GABA receptor alpha-3/beta-3/gamma-2 subunit
  • GABA receptor alpha-5/beta-3/gamma-2 subunit
  • Multidrug resistance-associated protein 4
  • Peripheral-Type Benzodiazepine Receptor
21 Ki 7 IC50
  • 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxide
  • 7-chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide
  • CDP
  • CHEMBL451
  • CHLORDIAZEPOXIDE
  • clopoxide
  • methaminodiazepoxide
  • 5-HT3A Serotonin Receptor
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • Alpha-1A adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • Norepinephrine transporter
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
  • Sodium-dependent dopamine transporter
  • Sodium-dependent noradrenaline transporter
  • Sodium-dependent serotonin transporter
  • Synaptic vesicular amine transporter
22 Ki 2 IC50
  • (R)Methyl-(1-methyl-2-phenyl-ethyl)-amine
  • METHAMPHETAMINE
  • METHAMPHETAMINE (+)
  • METHAMPHETAMINE (-)
  • Methyl-(1-methyl-2-phenyl-ethyl)-amine
  • Methyl-(1-methyl-2-phenyl-ethyl)-amine(methamphetamine)
  • Androgen Receptor
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Estradiol receptor beta (ERβ)
  • Estrogen receptor
  • Glucocorticoid
  • Glucocorticoid receptor
  • Mineralocorticoid receptor
  • Progesterone receptor
15 IC50
  • CHEMBL3261407
  • Androgen Receptor
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 3A
  • Estradiol receptor beta (ERβ)
  • Estrogen receptor
  • Glucocorticoid
  • Glucocorticoid receptor
  • Mineralocorticoid receptor
  • Progesterone receptor
14 IC50
  • CHEMBL3261425
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A (5HT2A)
  • Adrenergic receptor alpha-2
  • Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
  • Cerebral cortex alpha adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • D(3) dopamine receptor
  • Dopamine receptor
  • Mu-type opioid receptor
  • Potassium voltage-gated channel subfamily H member 2
  • Tissue inhibitor of metalloproteinases-3
8 Ki 20 IC50 4 Kd 3 EC50
  • (6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinolin-7-ium
  • (6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline
  • 5-Bromo-7-methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid (10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxo-octahydro-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-amide
  • 9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinolin-7-ium(Pergolide)
  • 9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline
  • 9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline(pergolide)
  • 9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline, mesylate (Pergolide)
  • CHEMBL531
  • PERGOLIDE
  • Permax
  • [2-(1H-Indol-4-yl)-ethyl]-methyl-amine
  • cid_47811
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • 5-hydroxytryptamine receptor 2B
  • 5-hydroxytryptamine receptor 7
  • Alpha-1A adrenergic receptor
  • Alpha-2A adrenergic receptor
  • Alpha-2C adrenergic receptor
  • Dopamine receptor
  • Histamine H1 receptor
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
  • Sigma non-opioid intracellular receptor 1
  • Sodium-dependent noradrenaline transporter
12 Ki
  • CHEMBL3289656
  • PTGER3
  • PTGFR
  • Prostaglandin D Synthase
  • Prostaglandin E2 receptor
  • Prostaglandin E2 receptor EP1 subtype (EP1)
  • Prostaglandin E2 receptor EP2 subtype
  • Prostaglandin E2 receptor EP4 subtype
  • Prostaglandin F2-alpha receptor
  • Prostaglandin Transporter
  • Prostanoid IP receptor
  • Prostanoid TP receptor
  • Thromboxane Alpha
19 Ki
  • (Z)-7-[(S)-6-((E)-(S)-3-Hydroxy-oct-1-enyl)-2-oxa-bicyclo[2.2.1]hept-5-yl]-hept-5-enoic acid
  • 7-[6-(3-Hydroxy-oct-1-enyl)-2-oxa-bicyclo[2.2.1]hept-5-yl]-hept-5-enoic acid
  • CHEMBL73010
  • U-46619
  • U46619
  • Cytochrome P450 2D1
  • Cytochrome P450 2D18
  • Cytochrome P450 2D2
  • Cytochrome P450 2D3
  • Cytochrome P450 2D6 (2D6)
  • Delta-type opioid receptor
  • Kappa-type opioid receptor
  • Mas-related G protein-coupled receptor X2 (MRGPRX2)
  • Mu-type opioid receptor
  • Opioid receptor
  • Potassium voltage-gated channel subfamily H member 2
  • Solute carrier family 22 member 1
13 IC50 3 EC50
  • (-)-Codeine
  • (Codeine)
  • (codeine)10-methoxy-4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraen-14-ol
  • 10-methoxy-4-methyl-(13R,14S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-ol(Dihydrocodeine)
  • 10-methoxy-4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraen-14-ol
  • 10-methoxy-4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraen-14-ol phosphate(codeine)
  • 10-methoxy-4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraen-14-ol(codeine (H3PO4))
  • 10-methoxy-4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraen-14-ol(codeine phosphate)
  • 10-methoxy-4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraen-14-ol(codeine)
  • 10-methoxy-4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraen-14-ol[codeine]
  • AMBENYL
  • BROMANYL
  • CODEINE
  • CODRIX
  • DIMETANE-DC
  • MYBANIL
  • TRIACIN-C
  • 5-HT3A Serotonin Receptor
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • Bile salt export pump
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • Norepinephrine Monoamine transporters
  • Norepinephrine transporter
  • Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
  • Sodium-dependent dopamine transporter
  • Sodium-dependent noradrenaline transporter
  • Sodium-dependent serotonin transporter
20 Ki 6 IC50
  • CHEMBL37744
  • ZIMELIDINE
  • Zimeldine
  • [3-(4-Bromo-phenyl)-3-pyridin-3-yl-allyl]-dimethyl-amine
  • [3-(4-Bromo-phenyl)-3-pyridin-3-yl-allyl]-dimethyl-amine (Zimelidine)
  • [3-(4-Bromo-phenyl)-3-pyridin-3-yl-allyl]-dimethyl-amine(Zimeldine)
  • cis -[3-(4-Bromo-phenyl)-3-pyridin-3-yl-allyl]-dimethyl-amine;HCl
  • trans-[3-(4-Bromo-phenyl)-3-pyridin-3-yl-allyl]-dimethyl-amine;C2H4O4
  • JAK1 (aa 866-1154)
  • JAK1/JAK2/TYK2
  • JAK1/TYK2
  • JAK2 (aa 808-1132)
  • JAK2/TYK2
  • JAK3 (aa 811-1124)
  • JAK3/JAK1
  • Non-receptor tyrosine-protein kinase TYK2
  • TYK2 (aa 888-1187)
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
2 Ki 28 IC50
  • DECERNOTINIB
  • US10112907, Example 00017
  • US10766894, Compound TABLE 1.2
  • VRT-831509
  • VX-509
  • JAK1 (aa 866-1154)
  • JAK1/JAK2/TYK2
  • JAK1/TYK2
  • JAK2 (aa 808-1132)
  • JAK2/TYK2
  • JAK3 (aa 811-1124)
  • JAK3/JAK1
  • Non-receptor tyrosine-protein kinase TYK2
  • TYK2 (aa 888-1187)
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
47 IC50
  • BARICITINIB
  • INCB-028050
  • LY-3009104
  • US10112907, Example 00034
  • US10766894, Compound TABLE 1.19
  • US10875847, Compound Baricitinib
  • Beta-lactamase (TEM-1)
  • Bile salt export pump
  • Oligopeptide transporter small intestine isoform
  • Oligopeptide transporter, kidney isoform
  • Organic anion-transporting polypeptide 1D1 (Oatp1d1)
  • Penicillin binding protein 2'
  • Penicillin-binding protein 1A
  • Penicillin-binding protein 2B
  • Penicillin-binding protein 2x
  • Solute carrier family 15 member 2
  • Solute carrier family 22 member 6
  • Solute carrier family 22 member 8
10 Ki 40 IC50
  • (+)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid(penicillin G)
  • (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid
  • (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid
  • 3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid
  • 3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid anion (Penicillin G)
  • 3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid(penicillin G)
  • BICILLIN
  • PENICILLIN G
  • PENICILLIN G PROCAINE
  • PENICILLIN-2
  • PERMAPEN
  • PFIZERPEN
  • PFIZERPEN-AS
  • benzylpenicillin
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Disintegrin and metalloproteinase domain-containing protein 17
  • Interstitial collagenase
  • Matrix metalloproteinase 10
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase 7
  • Matrix metalloproteinase-14 (MMP14)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
39 IC50
  • CHEMBL3337869
  • 3',5'-cyclic phosphodiesterase
  • Calcium channel (Type L)
  • Class I phosphodiesterase PDEB1
  • Homo sapiens phosphodiesterase 2A (PDE2A)
  • Monocarboxylate transporter 4
  • PDE5A/PDE6C
  • Phosphodiesterase 3 and 5 (PDE3 and PDE5)
  • Phosphodiesterase 7
  • Phosphodiesterase 8
  • Sodium channel protein type I I alpha subunit
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4D
3 Ki 25 IC50
  • 2-Acetoxy-Benzoic Acid
  • 3-Isobutyl-Methylxanthine
  • CHEBI:34795
  • ISOBUTYLMETHYLXANTHINE
  • 5-hydroxytryptamine receptor 1A
  • 5-hydroxytryptamine receptor 2A
  • Bile salt export pump
  • D(2) dopamine receptor
  • HTR1D
  • HTR2C
  • Norepinephrine Monoamine transporters
  • Norepinephrine transporter
  • Serotonin (5-HT) receptor
  • Serotonin 1B/1D receptor
  • Sodium-dependent dopamine transporter
  • Sodium-dependent serotonin transporter
16 Ki 5 IC50
  • 3-(2-Piperidin-4-yl-ethyl)-1H-indole
  • CHEMBL276520
  • Indalpine
  • 6-phospho-1-fructokinase
  • Bacterial dihydropteroate synthase
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Dihydrofolate Reductase (DHFR)
  • EDNRA
  • Endothelin receptor
  • Human immunodeficiency virus type 1 protease
  • Multidrug resistance-associated protein 4
  • exonuclease V (RecBCD complex), alpha chain
  • protein-arginine deiminase type-4
1 Ki 17 IC50 1 Kd
  • 4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonamide
  • 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide
  • ACETYLSULFAMETHOXAZOLE
  • BACTRIM
  • CHEMBL443
  • COTRIM
  • GANTANOL
  • GANTANOL-DS
  • RO 4-2130
  • SEPTRA
  • SULFAMETHOPRIM
  • SULFAMETHOPRIM-DS
  • SULFAMETHOXAZOLE SODIUM
  • SULFATRIM
  • SULFATRIM-DS
  • SULFATRIM-SS
  • SULMEPRIM
  • SULPHAMETHOXAZOLE
  • TRIMETH/SULFA
  • UROBAK
  • GRIA3
  • Glutamate receptor ionotropic, NMDA 1
  • Glutamate receptor ionotropic, kainate 1
  • Metabotropic glutamate receptor
  • Metabotropic glutamate receptor 1
  • Metabotropic glutamate receptor 2
  • Metabotropic glutamate receptor 3
  • Metabotropic glutamate receptor 4 (mGlu4)
  • Metabotropic glutamate receptor 4 (mGluR4)
  • Metabotropic glutamate receptor 5
  • Metabotropic glutamate receptor 8 (mGlu8)
  • Phospholipase C-beta-1
26 Ki 9 IC50
  • (+-)-MCPG
  • (R,S)-alpha-Methyl-4-carboxyphenylglycine
  • 4-(1-Amino-1-carboxy-ethyl)-benzoic acid
  • 4-(1-Amino-1-carboxy-ethyl)-benzoic acid(S-M4CPG)
  • CHEMBL299683
  • MCPG
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • Cellular retinoic acid-binding protein I
  • Cellular retinoic acid-binding protein II
  • Multidrug resistance-associated protein 4
  • Retinoic acid receptor alpha
  • Retinoic acid receptor beta
  • Retinoic acid receptor gamma
  • Retinoid X receptor alpha
  • Retinoid X receptor beta
  • Retinoid X receptor gamma
13 IC50 2 Kd
  • (2Z,4E6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
  • (7E,9E,11E,13Z)-retinoic acid
  • 13-RA
  • 13-cis-Vitamin A acid
  • 13-cis-retinoic acid
  • CHEMBL547
  • ISOTRETINOIN
  • Neovitamin A acid
  • isotretinoin
  • 5-hydroxytryptamine receptor 3A
  • Adrenergic receptor alpha-2
  • Adrenergic receptor beta
  • Alpha-1A adrenergic receptor
  • D(1A) dopamine receptor
  • D(2) dopamine receptor
  • HTR4
  • Serotonin (5-HT) receptor
  • Serotonin 1 (5-HT1) receptor
  • Serotonin 2 (5-HT2) receptor
  • Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor
  • Serotonin 4 (5-HT4) receptor
19 Ki 2 EC50
  • 4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-2-((R)-methoxy)-benzamide
  • 4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-benzamide
  • 4-Amino-N-(R)-1-aza-bicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxy-benzamide
  • CHEMBL27846
  • ZACOPRIDE,S
  • Carbonic Anhydrase III
  • Carbonic Anhydrase VA
  • Carbonic Anhydrase VB
  • Carbonic Anhydrase XIV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 12
  • Carbonic anhydrase 13 (CA XIII)
  • Carbonic anhydrase 2
  • Carbonic anhydrase 4
  • Carbonic anhydrase 6 (CA-VI)
  • Carbonic anhydrase 7
  • Carbonic anhydrase 9
14 Kd
  • CHEMBL3359180
  • 72 kDa type IV collagenase
  • A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)
  • A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)
  • Collagenase 3
  • Disintegrin and metalloproteinase domain-containing protein 17
  • Interstitial collagenase
  • Matrix metalloproteinase (2 and 3)
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase 7
  • Matrix metalloproteinase-14 (MMP14)
  • Matrix metalloproteinase-9
  • Stromelysin-1
30 IC50
  • CHEMBL3358155
  • 72 kDa type IV collagenase
  • A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)
  • A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)
  • Collagenase 3
  • Disintegrin and metalloproteinase domain-containing protein 17
  • Interstitial collagenase
  • Matrix metalloproteinase (2 and 3)
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase 7
  • Matrix metalloproteinase-14 (MMP14)
  • Matrix metalloproteinase-9
  • Stromelysin-1
29 IC50
  • CHEMBL3358156
  • 72 kDa type IV collagenase
  • A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)
  • A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)
  • Collagenase 3
  • Disintegrin and metalloproteinase domain-containing protein 17
  • Interstitial collagenase
  • Matrix metalloproteinase (2 and 3)
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase 7
  • Matrix metalloproteinase-14 (MMP14)
  • Matrix metalloproteinase-9
  • Stromelysin-1
30 IC50
  • CHEMBL3358158
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