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Report error Found 424 Enz. Inhib. hit(s) with Target = 'Cysteinyl leukotriene receptor 1/2'
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227045(CHEMBL354129)
Affinity DataIC50: 0.0310nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50023198(CHEMBL21333 | N-(4-oxo-2-(1H-tetrazol-5-yl)-4H-chr...)
Affinity DataIC50: 0.0440nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227075(CHEMBL171021)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227363(CHEMBL299837)
Affinity DataKi:  0.100nMAssay Description:Inhibition constant for displacement of [3H]LTD4 on guinea pig lung parenchymal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227072(CHEMBL169790)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227054(CHEMBL354530)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227053(CHEMBL170191)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069352((1-{(R)-1-{3-[(E)-2-(7,7-Dimethyl-5,6,7,8-tetrahyd...)
Affinity DataIC50: 0.170nMAssay Description:In vitro inhibition of [3H]LTD4 binding to LTD4 receptor of guinea pig lung membrane with human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069356([1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-...)
Affinity DataIC50: 0.190nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069352((1-{(R)-1-{3-[(E)-2-(7,7-Dimethyl-5,6,7,8-tetrahyd...)
Affinity DataIC50: 0.190nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068974(CGP-57698 | 2,2-Diethyl-N-[3-(7-fluoro-quinolin-2-...)
Affinity DataIC50: 0.200nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50009075(CHEMBL22033 | ICI 198615 | [1-(4-Benzenesulfonylam...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity against cysteinyl leukotriene D4 receptor from guinea pig lung membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227366(CHEMBL48927)
Affinity DataKi:  0.200nMAssay Description:Inhibition constant for displacement of [3H]LTD4 on guinea pig lung parenchymal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069375((R)-2-(1-((1-(3-(2-(5,7-dihydrothieno[3,4-b]pyridi...)
Affinity DataIC50: 0.210nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227364(CHEMBL299093)
Affinity DataKi:  0.25nMAssay Description:Inhibition constant for displacement of [3H]LTD4 on guinea pig lung parenchymal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227361(CHEMBL51585)
Affinity DataKi:  0.25nMAssay Description:Inhibition constant for displacement of [3H]LTD4 on guinea pig lung parenchymal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215369(CHEMBL368290)
Affinity DataIC50: 0.300nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227642(CHEMBL50562)
Affinity DataKi:  0.300nMAssay Description:Inhibition constant for displacement of [3H]LTD4 on guinea pig lung parenchymal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227358(CHEMBL412056)
Affinity DataKi:  0.300nMAssay Description:Inhibition constant for displacement of [3H]LTD4 on guinea pig lung parenchymal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227356(CHEMBL49944)
Affinity DataKi:  0.300nMAssay Description:Inhibition constant for displacement of [3H]LTD4 on guinea pig lung parenchymal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227365(CHEMBL300096)
Affinity DataKi:  0.300nMAssay Description:Inhibition constant for displacement of [3H]LTD4 on guinea pig lung parenchymal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227355(CHEMBL296821)
Affinity DataKi:  0.300nMAssay Description:Inhibition constant for displacement of [3H]LTD4 on guinea pig lung parenchymal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227640(CHEMBL297952)
Affinity DataKi:  0.300nMAssay Description:Inhibition constant for displacement of [3H]LTD4 on guinea pig lung parenchymal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069372((1-{(R)-1-{3-[(E)-2-(6,6-Dimethyl-6,7-dihydro-5H-[...)
Affinity DataIC50: 0.340nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069350((1-{(R)-1-{3-[(E)-2-(7,7-Dimethyl-6,7-dihydro-5H-[...)
Affinity DataIC50: 0.350nMAssay Description:In vitro inhibition of [3H]LTD4 binding to LTD4 receptor of guinea pig lung membrane with human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227047(CHEMBL172889)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215411(CHEMBL425675)
Affinity DataIC50: 0.400nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069372((1-{(R)-1-{3-[(E)-2-(6,6-Dimethyl-6,7-dihydro-5H-[...)
Affinity DataIC50: 0.430nMAssay Description:In vitro inhibition of [3H]LTD4 binding to LTD4 receptor of guinea pig lung membrane with human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052024(montelukast | CHEMBL787)
Affinity DataIC50: 0.430nMAssay Description:In vitro inhibition of [3H]LTD4 binding to LTD4 receptor of guinea pig lung membrane with human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227136(CHEMBL170100)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069355((R)-2-(1-((1-(3-(2-(6,7-dihydro-5H-cyclopenta[b]py...)
Affinity DataIC50: 0.5nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227390(CHEMBL301616)
Affinity DataKi:  0.5nMAssay Description:Inhibition constant for displacement of [3H]LTD4 on guinea pig lung parenchymal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215410(CHEMBL369421)
Affinity DataIC50: 0.5nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069364((R)-2-(1-((1-(3-(2-(6-butyl-5-methylpyridin-2-yl)v...)
Affinity DataIC50: 0.5nMAssay Description:In vitro inhibition of [3H]LTD4 binding to LTD4 receptor of guinea pig lung membrane with human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227144(CHEMBL83797)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50216211(CHEMBL143597)
Affinity DataIC50: 0.5nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069373(2-(1-(((1R)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-(...)
Affinity DataIC50: 0.510nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069357([1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-...)
Affinity DataIC50: 0.580nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069373(2-(1-(((1R)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-(...)
Affinity DataIC50: 0.630nMAssay Description:In vitro inhibition of [3H]LTD4 binding to LTD4 receptor of guinea pig lung membrane with human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052024(montelukast | CHEMBL787)
Affinity DataIC50: 0.640nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227063(CHEMBL170017)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50216211(CHEMBL143597)
Affinity DataIC50: 0.700nMAssay Description:In vitro inhibition of [3H]LTD4 binding to LTD4 receptor of guinea pig lung membrane with human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227389(CHEMBL51580)
Affinity DataKi:  0.700nMAssay Description:Inhibition constant for displacement of [3H]LTD4 on guinea pig lung parenchymal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069354([1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-...)
Affinity DataIC50: 0.730nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069370((1-{(R)-1-{3-[(E)-2-(2,3-Dihydro-thieno[3,2-b]pyri...)
Affinity DataIC50: 0.740nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069371((1-{(R)-1-{3-[(E)-2-(8,8-Dimethyl-5,6,7,8-tetrahyd...)
Affinity DataIC50: 0.75nMAssay Description:In vitro inhibition of [3H]LTD4 binding to LTD4 receptor of guinea pig lung membrane with human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50216210(CHEMBL141234)
Affinity DataIC50: 0.800nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50023198(CHEMBL21333 | N-(4-oxo-2-(1H-tetrazol-5-yl)-4H-chr...)
Affinity DataKi:  0.800nMAssay Description:Ability to antagonize LTD4 receptors isolated from guinea pig lung membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227367(CHEMBL48435)
Affinity DataKi:  0.800nMAssay Description:Inhibition constant for displacement of [3H]LTD4 on guinea pig lung parenchymal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068987(N-[3-(7-Chloro-quinolin-2-ylmethoxy)-phenyl]-2,2-d...)
Affinity DataIC50: 0.800nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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