Compile Data Set for Download or QSAR
Report error Found 586 Enz. Inhib. hit(s) with Target = 'Deoxyuridine 5'-triphosphate nucleotidohydrolase'
LigandPNGBDBM101748(CHEMBL2057911 | US8530490, 8)
Affinity DataIC50: 21nMAssay Description:Inhibition of human dUTPase assessed as production of [5-3H]dUMP from [5-3H]dUTP after 15 mins measured by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandPNGBDBM50391352(CHEMBL2147981)
Affinity DataIC50: 26nMAssay Description:Inhibition of human dUTPase-mediated formation of [5-3H]dUMP expressed in Escherichia coli BL21 (DE3) after 15 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50391350(CHEMBL2147979)
Affinity DataIC50: 28nMAssay Description:Inhibition of human dUTPase-mediated formation of [5-3H]dUMP expressed in Escherichia coli BL21 (DE3) after 15 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50395031(CHEMBL2163854)
Affinity DataIC50: 29nMAssay Description:Inhibition of human dUTPase assessed as reduction in [5-3H]dUMP production incubated for 15 mins by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM101774(US8530490, 34)
Affinity DataIC50: 30nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

LigandPNGBDBM101762(US8530490, 22)
Affinity DataIC50: 30nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

LigandPNGBDBM101778(US8530490, 38)
Affinity DataIC50: 30nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

LigandPNGBDBM101762(US8530490, 22)
Affinity DataIC50: 30nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

LigandPNGBDBM50391347(CHEMBL2147976)
Affinity DataIC50: 31nMAssay Description:Inhibition of human dUTPase-mediated formation of [5-3H]dUMP expressed in Escherichia coli BL21 (DE3) after 15 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50391351(CHEMBL2147980)
Affinity DataIC50: 33nMAssay Description:Inhibition of human dUTPase-mediated formation of [5-3H]dUMP expressed in Escherichia coli BL21 (DE3) after 15 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM101889(CHEMBL2057599 | US8530490, 159)
Affinity DataIC50: 35nMAssay Description:Inhibition of human dUTPase-mediated formation of [5-3H]dUMP expressed in Escherichia coli BL21 (DE3) after 15 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM101889(CHEMBL2057599 | US8530490, 159)
Affinity DataIC50: 35nMAssay Description:Inhibition of human dUTPase assessed as production of [5-3H]dUMP from [5-3H]dUTP after 15 mins measured by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  37nMAssay Description:Binding affinity to human DUT incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM101847(CHEMBL2147985 | US8530490, 110)
Affinity DataIC50: 39nMAssay Description:Inhibition of human dUTPase-mediated formation of [5-3H]dUMP expressed in Escherichia coli BL21 (DE3) after 15 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM5563(US8530490, 173 | US8530490, 175)
Affinity DataIC50: 40nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

LigandPNGBDBM101837(US8530490, 100)
Affinity DataIC50: 40nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

LigandPNGBDBM101763(CHEMBL2057909 | US8530490, 23)
Affinity DataIC50: 40nMAssay Description:Inhibition of human dUTPase assessed as production of [5-3H]dUMP from [5-3H]dUTP after 15 mins measured by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandPNGBDBM101764(US8530490, 24)
Affinity DataIC50: 40nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

LigandPNGBDBM101749(US8530490, 9)
Affinity DataIC50: 40nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

LigandPNGBDBM101781(US8530490, 41)
Affinity DataIC50: 40nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

LigandPNGBDBM101764(US8530490, 24)
Affinity DataIC50: 40nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

LigandPNGBDBM101763(CHEMBL2057909 | US8530490, 23)
Affinity DataIC50: 40nMAssay Description:Inhibition of human dUTPase-mediated formation of [5-3H]dUMP expressed in Escherichia coli BL21 (DE3) after 15 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM101767(US8530490, 27)
Affinity DataIC50: 40nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

LigandPNGBDBM101842(CHEMBL2147986 | US8530490, 105)
Affinity DataIC50: 41nMAssay Description:Inhibition of human dUTPase-mediated formation of [5-3H]dUMP expressed in Escherichia coli BL21 (DE3) after 15 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50391352(CHEMBL2147981)
Affinity DataEC50:  49nMAssay Description:Inhibition of human dUTPase-mediated cell proliferation in HeLa S3 cells assessed as compound concentration required to reduce 50% of 1 uM of FdUrd T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM101763(CHEMBL2057909 | US8530490, 23)
Affinity DataIC50: 50nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

LigandPNGBDBM101763(CHEMBL2057909 | US8530490, 23)
Affinity DataIC50: 50nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

LigandPNGBDBM101847(CHEMBL2147985 | US8530490, 110)
Affinity DataIC50: 50nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

LigandPNGBDBM50395031(CHEMBL2163854)
Affinity DataEC50:  50nMAssay Description:Inhibition of dUTPase in human HeLa S3 cells assessed as potentiation of 1 uM FdUrd-induced decrease in cell density incubated for 48 hrs by crystal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50395047(CHEMBL2163852)
Affinity DataIC50: 58nMAssay Description:Inhibition of human dUTPase assessed as reduction in [5-3H]dUMP production incubated for 15 mins by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM101745(US8530490, 5)
Affinity DataIC50: 60nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM101745(US8530490, 5)
Affinity DataIC50: 60nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50388166(CHEMBL2057910)
Affinity DataIC50: 62nMAssay Description:Inhibition of human dUTPase assessed as production of [5-3H]dUMP from [5-3H]dUTP after 15 mins measured by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandPNGBDBM101847(CHEMBL2147985 | US8530490, 110)
Affinity DataEC50:  66nMAssay Description:Inhibition of human dUTPase-mediated cell proliferation in HeLa S3 cells assessed as compound concentration required to reduce 50% of 1 uM of FdUrd T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50395030(CHEMBL2163866)
Affinity DataIC50: 67nMAssay Description:Inhibition of human dUTPase assessed as reduction in [5-3H]dUMP production incubated for 15 mins by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM101838(US8530490, 101)
Affinity DataIC50: 70nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

LigandPNGBDBM50395030(CHEMBL2163866)
Affinity DataEC50:  70nMAssay Description:Inhibition of dUTPase in human HeLa S3 cells assessed as potentiation of 1 uM FdUrd-induced decrease in cell density incubated for 48 hrs by crystal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50391350(CHEMBL2147979)
Affinity DataEC50:  71nMAssay Description:Inhibition of human dUTPase-mediated cell proliferation in HeLa S3 cells assessed as compound concentration required to reduce 50% of 1 uM of FdUrd T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50391348(CHEMBL2147977)
Affinity DataIC50: 73nMAssay Description:Inhibition of human dUTPase-mediated formation of [5-3H]dUMP expressed in Escherichia coli BL21 (DE3) after 15 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM101906(CHEMBL2147975 | US8530490, 178)
Affinity DataIC50: 73nMAssay Description:Inhibition of human dUTPase-mediated formation of [5-3H]dUMP expressed in Escherichia coli BL21 (DE3) after 15 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50391341(CHEMBL2147987)
Affinity DataIC50: 82nMAssay Description:Inhibition of human dUTPase-mediated formation of [5-3H]dUMP expressed in Escherichia coli BL21 (DE3) after 15 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM101748(CHEMBL2057911 | US8530490, 8)
Affinity DataIC50: 90nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

LigandPNGBDBM101748(CHEMBL2057911 | US8530490, 8)
Affinity DataIC50: 90nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

LigandPNGBDBM101783(US8530490, 43)
Affinity DataIC50: 90nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

LigandPNGBDBM50391341(CHEMBL2147987)
Affinity DataEC50:  96nMAssay Description:Inhibition of human dUTPase-mediated cell proliferation in HeLa S3 cells assessed as compound concentration required to reduce 50% of 1 uM of FdUrd T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM101777(US8530490, 37)
Affinity DataIC50: 100nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

LigandPNGBDBM50391348(CHEMBL2147977)
Affinity DataEC50:  100nMAssay Description:Inhibition of human dUTPase-mediated cell proliferation in HeLa S3 cells assessed as compound concentration required to reduce 50% of 1 uM of FdUrd T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM101765(US8530490, 25)
Affinity DataIC50: 100nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

LigandPNGBDBM101780(US8530490, 40)
Affinity DataIC50: 100nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

LigandPNGBDBM101808(US8530490, 68)
Affinity DataIC50: 110nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2013
Entry Details
US Patent

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