Compile Data Set for Download or QSAR
Report error Found 119 Enz. Inhib. hit(s) with Target = 'GTPase HRas'
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human H-rasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of HRAS (unknown origin) farnesylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50097071(4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to HRAS (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50063453(1-[4-((S)-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclo...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of H-Ras (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50089967(5-{4-[Bis-(2-chloro-ethyl)-amino]-benzoylamino}-1H...)
Affinity DataIC50: 15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50089960(5-{4-[Bis-(2-chloro-ethyl)-amino]-benzoylamino}-1H...)
Affinity DataIC50: 15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50089961(5-{4-[Bis-(2-chloro-ethyl)-amino]-benzoylamino}-1-...)
Affinity DataIC50: 15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50089969(5-[Bis-(2-chloro-ethyl)-amino]-benzofuran-2-carbox...)
Affinity DataIC50: 15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50089962(5-{4-[Bis-(2-chloro-ethyl)-amino]-benzoylamino}-be...)
Affinity DataIC50: 15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50089978(5-[Bis-(2-chloro-ethyl)-amino]-1H-indole-2-carboxy...)
Affinity DataIC50: 20nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50089971(5-[Bis-(2-chloro-ethyl)-amino]-1-methyl-1H-indole-...)
Affinity DataIC50: 20nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707354(N-(3-(2-(dimethylamino)ethoxy)phenyl)-2-(6-fluoro-...)
Affinity DataKd:  36nMAssay Description:Dissociation constants were obtained by monitoring changes in chemical shifts as a function of ligand concentration. The changes in chemical shifts (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50520327(CHEMBL4456044)
Affinity DataKd:  51nMAssay Description:Inhibition GST-tagged recombinant HRAS G12V mutant (1 to 166 amino acids) (unknown origin) expressed in Escherichia coli C41(DE3) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060139([(S)-1-((4-Benzyloxy-benzyl)-{[(1-phenyl-cyclobuty...)
Affinity DataIC50: 88nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601398(CHEMBL5174384)
Affinity DataIC50: 100nMAssay Description:Inhibition of [35S]methionine labelled HRAS in rat Rat1 cells by immunoprecipitation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601400(CHEMBL5171806)
Affinity DataIC50: 100nMAssay Description:Inhibition of HRAS (unknown origin) transfected in BALB/c nude mouse incubated for 3 days measured by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707355(US20240408064, Compound 10097)
Affinity DataKd:  108nMAssay Description:Dissociation constants were obtained by monitoring changes in chemical shifts as a function of ligand concentration. The changes in chemical shifts (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060141([(S)-1-{(4-Benzyloxy-benzyl)-[(2-methyl-2-phenyl-p...)
Affinity DataIC50: 180nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060146([(S)-1-((4-Benzyloxy-benzyl)-{[(1-phenyl-cycloprop...)
Affinity DataIC50: 180nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060140([(S)-1-{(4-Benzyloxy-benzyl)-[(2-cyano-2-phenyl-et...)
Affinity DataIC50: 190nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50055659(CHEMBL11252 | 2N-[5-(3-amino-3-iminopropylcarbamoy...)
Affinity DataIC50: 200nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060145([(S)-1-{(4-Benzyloxy-benzyl)-[((S)-2-phenyl-propyl...)
Affinity DataIC50: 300nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060138([(S)-1-{(4-Benzyloxy-benzyl)-[(2-phenyl-propylcarb...)
Affinity DataIC50: 310nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060142([(S)-1-((4-Benzyloxy-benzyl)-{[(1-phenyl-cyclopent...)
Affinity DataIC50: 330nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060149([(S)-1-{(4-Benzyloxy-benzyl)-[(2-phenyl-butylcarba...)
Affinity DataIC50: 400nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707360(US20240408064, Compound 11032)
Affinity DataKd:  452nMAssay Description:SPR experiments were performed using the P4SPR from Affinité Instruments using Ni-NTA immobilization chips and his-tagged protein. Ni-NTA coated surf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060150([(S)-1-{(4-Benzyloxy-benzyl)-[((R)-2-phenyl-propyl...)
Affinity DataIC50: 570nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060144([(S)-1-{(4-Benzyloxy-benzyl)-[((R)-1-methyl-2-phen...)
Affinity DataIC50: 710nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707360(US20240408064, Compound 11032)
Affinity DataKd:  772nMAssay Description:MST experiments were performed with a Monolith NT.115 Pico (NanoTemper Technologies, Munich, Germany). Fluorescence labeling of GDP-HRasG12V was achi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060152([(S)-1-{(4-Benzyloxy-benzyl)-[(2-ethyl-2-phenyl-bu...)
Affinity DataIC50: 1.00E+3nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060148([(S)-1-{(4-Benzyloxy-benzyl)-[(2-phenyl-pentylcarb...)
Affinity DataIC50: 1.00E+3nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50287960(1-[(2R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro for inhibition of nucleotide exchange process of oncogenic RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707359(US20240408064, Compound 10160)
Affinity DataKd:  1.28E+3nMAssay Description:Dissociation constants were obtained by monitoring changes in chemical shifts as a function of ligand concentration. The changes in chemical shifts (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50287951(3-[(3aS,4R,6R,6aR)-6-(4-Chloro-6-methoxy-3-methyl-...)
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro for inhibition of nucleotide exchange process of oncogenic RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707351(US20240408064, Compound 10053)
Affinity DataKd:  1.53E+3nMAssay Description:Dissociation constants were obtained by monitoring changes in chemical shifts as a function of ligand concentration. The changes in chemical shifts (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707343(US20240408064, Compound 10014)
Affinity DataKd:  2.32E+3nMAssay Description:Dissociation constants were obtained by monitoring changes in chemical shifts as a function of ligand concentration. The changes in chemical shifts (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707340(US20240408064, Compound 10002)
Affinity DataKd:  2.51E+3nMAssay Description:Dissociation constants were obtained by monitoring changes in chemical shifts as a function of ligand concentration. The changes in chemical shifts (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50478506(Ophirapstanol Trisulfate)
Affinity DataIC50: 2.55E+3nMAssay Description:Inhibition of human recombinant p21RAS by GDPX assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50646348(CHEMBL5592316)
Affinity DataEC50:  2.60E+3nMAssay Description:Induction of Rluc8-tagged and GFP2-tagged H-Ras G12V mutant (unknown origin) disruption extracted from HEK293-EBNA cells assessed as intracellular H-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50287961((E)-5-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyra...)
Affinity DataIC50: 3.00E+3nMAssay Description:In vitro for inhibition of nucleotide exchange process of oncogenic RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707353(US20240408064, Compound 10086)
Affinity DataKd:  3.18E+3nMAssay Description:Dissociation constants were obtained by monitoring changes in chemical shifts as a function of ligand concentration. The changes in chemical shifts (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707358(US20240408064, Compound 10159)
Affinity DataKd:  3.19E+3nMAssay Description:Dissociation constants were obtained by monitoring changes in chemical shifts as a function of ligand concentration. The changes in chemical shifts (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707344(US20240408064, Compound 10018)
Affinity DataKd:  3.36E+3nMAssay Description:Dissociation constants were obtained by monitoring changes in chemical shifts as a function of ligand concentration. The changes in chemical shifts (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707352(1-(azetidin-1-yl)-2-(6-fluoro-1H-indol-3-yl) propa...)
Affinity DataKd:  3.75E+3nMAssay Description:Dissociation constants were obtained by monitoring changes in chemical shifts as a function of ligand concentration. The changes in chemical shifts (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50059857([(S)-1-[(4-Benzyloxy-benzyl)-(phenethylcarbamoyl-m...)
Affinity DataIC50: 4.30E+3nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50287943((E)-4-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyra...)
Affinity DataIC50: 4.70E+3nMAssay Description:In vitro for inhibition of nucleotide exchange process of oncogenic RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50249989(CHEMBL1387422)
Affinity DataEC50:  5.00E+3nMAssay Description:Induction of Rluc8-tagged and GFP2-tagged H-Ras G12V mutant (unknown origin) disruption extracted from HEK293-EBNA cells assessed as intracellular H-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50287946(1-[(2R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl...)
Affinity DataIC50: 5.00E+3nMAssay Description:In vitro for inhibition of nucleotide exchange process of oncogenic RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707344(US20240408064, Compound 10018)
Affinity DataKd:  5.18E+3nMAssay Description:Dissociation constants were obtained by monitoring changes in chemical shifts as a function of ligand concentration. The changes in chemical shifts (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707345(US20240408064, Compound 10025)
Affinity DataKd:  6.00E+3nMAssay Description:Dissociation constants were obtained by monitoring changes in chemical shifts as a function of ligand concentration. The changes in chemical shifts (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

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