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Report error Found 44 Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase SUV39H1'
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM588052((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human SUV39H1 using Histone H3 and [3H]SAM as substrate incubated for 30 mins to 1 hr by HotSpot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50590375(CHEMBL5187396)
Affinity DataIC50: 1nMAssay Description:Inhibition of human SUV39H1 using Histone H3 and [3H]SAM as substrate incubated for 30 mins to 1 hr by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50396027(CHEMBL499593)
Affinity DataIC50: 66nMAssay Description:Inhibition of SUV39H1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50134315(CHEMBL331627 | 7-hydroxy-11-hydroxymethyl-12-methy...)
Affinity DataIC50: 260nMAssay Description:Inhibition of SUV39H1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50396026(CHEMBL2172426)
Affinity DataIC50: 530nMAssay Description:Inhibition of SUV39H1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50315537(chaetocin | CHEMBL1089316)
Affinity DataIC50: 800nMAssay Description:Inhibition of human SUV39H1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50315537(chaetocin | CHEMBL1089316)
Affinity DataIC50: 800nMAssay Description:Inhibition of SUV39H1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50315537(chaetocin | CHEMBL1089316)
Affinity DataIC50: 800nMAssay Description:Inhibition of human Histone-lysine N-methyltransferase SUV39H1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | S-[1-(adenin-9-yl)-1,5-dideoxy-beta-D-rib...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of SUV39H1 (unknown origin) by HMT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50622656(CHEMBL5402316)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human SUV39H1 using Biotin-tagged histone H3 and 3H-SAM as substrate incubated for 1 hrs by TopCount scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | S-[1-(adenin-9-yl)-1,5-dideoxy-beta-D-rib...)
Affinity DataKi:  4.90E+3nMAssay Description:Inhibition of SUV39H1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50651354(CHEMBL5633108)
Affinity DataIC50: 7.00E+3nMAssay Description:Displacement of 3H-SAM from SUV39H1 (unknown origin) using biotinylated-histone H3 peptide as substrate incubated for 45 mins by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50063670(CHEMBL3397332)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of SUV39H1 (unknown origin) by HMT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SUV39H1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50396025(CHEMBL1089088)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SUV39H1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SUV39H1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SUV39H1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50651365(CHEMBL5632617)
Affinity DataIC50: 1.40E+4nMAssay Description:Displacement of 3H-SAM from SUV39H1 (unknown origin) using biotinylated-histone H3 peptide as substrate incubated for 45 mins by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50651356(CHEMBL5633177)
Affinity DataIC50: 1.60E+4nMAssay Description:Displacement of 3H-SAM from SUV39H1 (unknown origin) using biotinylated-histone H3 peptide as substrate incubated for 45 mins by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50651351(CHEMBL5633498)
Affinity DataIC50: 1.60E+4nMAssay Description:Displacement of 3H-SAM from SUV39H1 (unknown origin) using biotinylated-histone H3 peptide as substrate incubated for 45 mins by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50396981(CHEMBL2171174)
Affinity DataKi: >2.00E+4nMAssay Description:Competitive inhibition of SUV39H1 (unknown origin) using histone-H3 (1 to 21) as substrate preincubated for 10 mins followed by substrate addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50651364(CHEMBL5633588)
Affinity DataIC50: 2.20E+4nMAssay Description:Displacement of 3H-SAM from SUV39H1 (unknown origin) using biotinylated-histone H3 peptide as substrate incubated for 45 mins by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50651346(CHEMBL5631669)
Affinity DataIC50: 2.30E+4nMAssay Description:Displacement of 3H-SAM from SUV39H1 (unknown origin) using biotinylated-histone H3 peptide as substrate incubated for 45 mins by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50651347(CHEMBL5632481)
Affinity DataIC50: 3.50E+4nMAssay Description:Displacement of 3H-SAM from SUV39H1 (unknown origin) using biotinylated-histone H3 peptide as substrate incubated for 45 mins by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50651350(CHEMBL5631576)
Affinity DataIC50: 4.70E+4nMAssay Description:Displacement of 3H-SAM from SUV39H1 (unknown origin) using biotinylated-histone H3 peptide as substrate incubated for 45 mins by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50396980(CHEMBL2171169)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of SUV39H1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50443018(CHEMBL3087503)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of SUV39H1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50443020(CHEMBL3087501)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of SUV39H1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50443019(CHEMBL3087502)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of SUV39H1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50400779(CHEMBL2204998)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SUV39H1 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SUV39H1 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50396016(CHEMBL2169918)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SUV39H1 using [3H]-SAM as substrate preincubated for 10 mins before substrate addition measured after 30 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50396017(CHEMBL2172427)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SUV39H1 using [3H]-SAM as substrate preincubated for 10 mins before substrate addition measured after 30 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50396977(CHEMBL2171172)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of SUV39H1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50396979(CHEMBL2171170)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of SUV39H1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50396978(CHEMBL2171171)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of SUV39H1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50396981(CHEMBL2171174)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of SUV39H1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50396980(CHEMBL2171169)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of SUV39H1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50400778(CHEMBL2204995)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SUV39H1 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50651349(CHEMBL5631984)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of 3H-SAM from SUV39H1 (unknown origin) using biotinylated-histone H3 peptide as substrate incubated for 45 mins by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of SUV39H1 (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50651353(CHEMBL5631287)
Affinity DataIC50: 2.00E+5nMAssay Description:Displacement of 3H-SAM from SUV39H1 (unknown origin) using biotinylated-histone H3 peptide as substrate incubated for 45 mins by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50651348(CHEMBL5633117)
Affinity DataIC50: 2.00E+5nMAssay Description:Displacement of 3H-SAM from SUV39H1 (unknown origin) using biotinylated-histone H3 peptide as substrate incubated for 45 mins by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50651352(CHEMBL5632319)
Affinity DataIC50: 2.00E+5nMAssay Description:Displacement of 3H-SAM from SUV39H1 (unknown origin) using biotinylated-histone H3 peptide as substrate incubated for 45 mins by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed