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LigandPNGBDBM15234((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)
Affinity DataIC50:  4.20nMpH: 7.4 T: 22°CAssay Description:Ptdlns 3-kinase enzyme activity was assayed by its converting Ptdlns(4,5)P2 into PtdIns(3,4,5)P3 in the presence of radioactive ATP. After reaction,...More data for this Ligand-Target Pair
LigandPNGBDBM15234((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)
Affinity DataIC50:  17.6nMAssay Description:Inhibition of PI3K (unknown origin) by fluorescence energy transfer assayMore data for this Ligand-Target Pair
LigandPNGBDBM50262092(5-[Methyl-(7-nitro-benzo[1,2,5]oxadiazol-4-yl)-ami...)
Affinity DataIC50:  24.2nMAssay Description:Inhibition of PI3K (unknown origin) by fluorescence energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262097(1-((5-acetoxy-11-hydroxy-4-(methoxymethyl)-4a,6a-d...)
Affinity DataIC50:  105nMAssay Description:Inhibition of PI3K (unknown origin) by fluorescence energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262093(11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-1-((me...)
Affinity DataIC50:  119nMAssay Description:Inhibition of PI3K (unknown origin) by fluorescence energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262095((Z)-6-(((5-acetoxy-11-hydroxy-4-(methoxymethyl)-4a...)
Affinity DataIC50:  128nMAssay Description:Inhibition of PI3K (unknown origin) by fluorescence energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262096(6-(((11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-5...)
Affinity DataIC50:  174nMAssay Description:Inhibition of PI3K (unknown origin) by fluorescence energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262094(11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-1-((me...)
Affinity DataIC50:  262nMAssay Description:Inhibition of PI3K (unknown origin) by fluorescence energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM12915(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Affinity DataIC50:  1.40E+3nM Kd:  210nMpH: 7.2 T: 20°CAssay Description:Binding was detected as a change in the intrinsic tryptophan fluorescence of the PI3K upon the addition of inhibitor. The inhibitor was incubated wit...More data for this Ligand-Target Pair
LigandPNGBDBM15236(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Affinity DataIC50:  1.80E+3nM Kd:  170nMpH: 7.2 T: 20°CAssay Description:Binding was detected as a change in the intrinsic tryptophan fluorescence of the PI3K upon the addition of inhibitor. The inhibitor was incubated wit...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM195606(NCT-503)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM195606(NCT-503)
Affinity DataIC50:  2.50E+3nMpH: 8.0 T: 25°CAssay Description:PHGDH assay buffer contained 50 mM TEA pH 8.0, 10 mM MgCl2, 0.05% BSA, and 0.01% Tween-20. PHGDH enzyme buffer consisted of assay buffer with 20 nM P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM195605(NCT-502 | US11225469, Compound 72)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM195605(NCT-502 | US11225469, Compound 72)
Affinity DataIC50:  3.70E+3nMpH: 8.0 T: 25°CAssay Description:PHGDH assay buffer contained 50 mM TEA pH 8.0, 10 mM MgCl2, 0.05% BSA, and 0.01% Tween-20. PHGDH enzyme buffer consisted of assay buffer with 20 nM P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataIC50:  3.80E+3nM Kd:  280nMpH: 7.2 T: 20°CAssay Description:Binding was detected as a change in the intrinsic tryptophan fluorescence of the PI3K upon the addition of inhibitor. The inhibitor was incubated wit...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271477(CHEMBL4129748)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271521(CHEMBL2140870)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM58473(MLS001172437 | N-(4-methyl-2-pyridinyl)-4-[3-(trif...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271523(CHEMBL4129229 | US11225469, Compound 252)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271429(CHEMBL4125702 | US11225469, Compound 294)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271412(CHEMBL4125871 | US11225469, Compound 278)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50232861(CHEMBL2131647 | US11225469, Compound 24)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271461(CHEMBL2143378 | US11225469, Compound 26)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271417(CHEMBL4127018 | US11225469, Compound 250)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271438(CHEMBL2137247 | US11225469, Compound 35)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271522(CHEMBL4126002 | US11225469, Compound 251)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271425(CHEMBL4126752)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271396(CHEMBL4129360)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271418(CHEMBL4128391 | US11225469, Compound 258)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271426(CHEMBL4129099)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271427(CHEMBL4127154 | US11225469, Compound 275)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271476(CHEMBL4127403)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271415(CHEMBL4125786 | US11225469, Compound 264)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271458(CHEMBL3559789 | US11225469, Compound 30)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  9.00E+3nM Kd:  290nMpH: 7.2 T: 20°CAssay Description:Binding was detected as a change in the intrinsic tryptophan fluorescence of the PI3K upon the addition of inhibitor. The inhibitor was incubated wit...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271434(CHEMBL4128309 | US11225469, Compound 276)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271422(CHEMBL4126183)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271398(CHEMBL4126631 | US11225469, Compound 297)
Affinity DataIC50:  9.90E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271420(CHEMBL4129623 | US11225469, Compound 266)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271405(CHEMBL4125915 | US11225469, Compound 262)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262138(5-((5-acetoxy-11-hydroxy-4-(methoxymethyl)-4a,6a-d...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PI3K (unknown origin) by fluorescence energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271474(CHEMBL2144036 | US11225469, Compound 34)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262139(2-acetamido-6-((5-acetoxy-11-hydroxy-4-(methoxymet...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PI3K (unknown origin) by fluorescence energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262043(6-((11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-5-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PI3K (unknown origin) by fluorescence energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271506(CHEMBL2135778 | US11225469, Compound 116)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271410(CHEMBL4127362 | US11225469, Compound 284)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271414(CHEMBL4128834 | US11225469, Compound 296)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271419(CHEMBL4128252 | US11225469, Compound 263)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271428(CHEMBL4128967 | US11225469, Compound 298)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50271416(CHEMBL4127149)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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