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Found 56 with Last Name = 'guan' and Initial = 'w'
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132351(({4-[6-(2,6-Dichloro-phenyl)-8-(3-dimethylamino-pr...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Mus musculus)
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50509436(CHEMBL4463027)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of DPP4 in C57BL/6 mouse serum pre-incubated for 5 mins followed by Gly-Pro-7-AMC substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Mus musculus)
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50509435(CHEMBL4593371)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of DPP4 in C57BL/6 mouse serum pre-incubated for 5 mins followed by Gly-Pro-7-AMC substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Mus musculus)
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50509441(CHEMBL4452661)
Affinity DataIC50:  2nMAssay Description:Inhibition of DPP4 in C57BL/6 mouse serum pre-incubated for 5 mins followed by Gly-Pro-7-AMC substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132348(({4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-di...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Mus musculus)
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50509440(CHEMBL4533178)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of DPP4 in C57BL/6 mouse serum pre-incubated for 5 mins followed by Gly-Pro-7-AMC substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
The First Affiliated Hospital Of Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50512267(CHEMBL4471571)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human recombinant N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Mus musculus)
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50509434(CHEMBL4443285)
Affinity DataIC50:  3nMAssay Description:Inhibition of DPP4 in C57BL/6 mouse serum pre-incubated for 5 mins followed by Gly-Pro-7-AMC substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Mus musculus)
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50509433(CHEMBL4532312)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of DPP4 in C57BL/6 mouse serum pre-incubated for 5 mins followed by Gly-Pro-7-AMC substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
The First Affiliated Hospital Of Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50512265(CHEMBL4587135)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of human recombinant N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
The First Affiliated Hospital Of Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of human recombinant N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
The First Affiliated Hospital Of Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50512263(CHEMBL4580829)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of human recombinant N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Mus musculus)
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM11162((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Affinity DataIC50:  15nMAssay Description:Inhibition of DPP4 in C57BL/6 mouse serum pre-incubated for 5 mins followed by Gly-Pro-7-AMC substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM3071(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 38 | 2-ani...)
Affinity DataIC50:  16nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
The First Affiliated Hospital Of Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50512266(CHEMBL4461676)
Affinity DataIC50:  26nMAssay Description:Inhibition of human recombinant N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
The First Affiliated Hospital Of Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50512268(CHEMBL4444509)
Affinity DataIC50:  38nMAssay Description:Inhibition of human recombinant N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
The First Affiliated Hospital Of Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50512264(CHEMBL4452825)
Affinity DataIC50:  76nMAssay Description:Inhibition of human recombinant N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132352(({3-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-di...)
Affinity DataIC50:  77nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Mus musculus)
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50509437(CHEMBL4445546)
Affinity DataIC50:  82nMAssay Description:Inhibition of DPP4 in C57BL/6 mouse serum pre-incubated for 5 mins followed by Gly-Pro-7-AMC substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Mus musculus)
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50509439(CHEMBL4442618)
Affinity DataIC50:  116nMAssay Description:Inhibition of DPP4 in C57BL/6 mouse serum pre-incubated for 5 mins followed by Gly-Pro-7-AMC substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Mus musculus)
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50509438(CHEMBL4584732)
Affinity DataIC50:  168nMAssay Description:Inhibition of DPP4 in C57BL/6 mouse serum pre-incubated for 5 mins followed by Gly-Pro-7-AMC substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132353(CHEMBL102801 | {4-[6-(2,6-Dichloro-phenyl)-8-methy...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132350(({4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-di...)
Affinity DataIC50:  750nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132349(CHEMBL320374 | {5-[6-(2,6-Dichloro-phenyl)-8-methy...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103784(CHEMBL77638 | Phosphoric acid mono-(4-{2-acetylami...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of binding to Yes SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103784(CHEMBL77638 | Phosphoric acid mono-(4-{2-acetylami...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of binding to Src SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103781((4-{2-Acetylamino-2-[1-(3-carbamoyl-4-cyclohexylme...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of binding to Src SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103782((4-{2-Acetylamino-2-[(S)-1-(3-carbamoyl-4-cyclohex...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of binding to Src SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103780(CHEMBL308734 | [4-{2-Acetylamino-2-[(S)-1-(3-carba...)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of binding to Src SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103786((4-{2-[1-(3-Carbamoyl-4-cyclohexylmethoxy-phenyl)-...)
Affinity DataIC50:  3.54E+4nMAssay Description:Inhibition of binding to Src SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103781((4-{2-Acetylamino-2-[1-(3-carbamoyl-4-cyclohexylme...)
Affinity DataIC50:  9.45E+4nMAssay Description:Inhibition of binding to Yes SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103782((4-{2-Acetylamino-2-[(S)-1-(3-carbamoyl-4-cyclohex...)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibition of binding to Yes SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103780(CHEMBL308734 | [4-{2-Acetylamino-2-[(S)-1-(3-carba...)
Affinity DataIC50:  1.56E+5nMAssay Description:Inhibition of binding to Yes SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103786((4-{2-[1-(3-Carbamoyl-4-cyclohexylmethoxy-phenyl)-...)
Affinity DataIC50:  3.03E+5nMAssay Description:Inhibition of binding to Yes SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103787((4-{2-Acetylamino-2-[(S)-1-(3-carbamoyl-4-cyclohex...)
Affinity DataIC50:  3.70E+5nMAssay Description:Inhibition of binding to Src SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103785(CHEMBL263721 | {4-[2-Acetylamino-2-(3-carbamoyl-4-...)
Affinity DataIC50:  3.78E+5nMAssay Description:Inhibition of binding to Src SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103784(CHEMBL77638 | Phosphoric acid mono-(4-{2-acetylami...)
Affinity DataIC50:  4.41E+5nMAssay Description:Inhibition of binding to Zap70 protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103787((4-{2-Acetylamino-2-[(S)-1-(3-carbamoyl-4-cyclohex...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of binding to Yes SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103781((4-{2-Acetylamino-2-[1-(3-carbamoyl-4-cyclohexylme...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of binding to Zap70 protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103786((4-{2-[1-(3-Carbamoyl-4-cyclohexylmethoxy-phenyl)-...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of binding to Zap70 protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103785(CHEMBL263721 | {4-[2-Acetylamino-2-(3-carbamoyl-4-...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of binding to Zap70 protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103783(CHEMBL308164 | {4-[2-Acetylamino-2-(3-carbamoyl-4-...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of binding to Src SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103779(CHEMBL430825 | Trifluoro-methanesulfonic acid 4-{2...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of binding to Zap70 protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103779(CHEMBL430825 | Trifluoro-methanesulfonic acid 4-{2...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of binding to Src SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103780(CHEMBL308734 | [4-{2-Acetylamino-2-[(S)-1-(3-carba...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of binding to Zap70 protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103779(CHEMBL430825 | Trifluoro-methanesulfonic acid 4-{2...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of binding to Yes SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103778(CHEMBL311114 | [5-{2-[1-(3-Carbamoyl-4-cyclohexylm...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of binding to Zap70 protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103778(CHEMBL311114 | [5-{2-[1-(3-Carbamoyl-4-cyclohexylm...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of binding to Yes SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103788((5-{2-[1-(3-Carbamoyl-4-cyclohexylmethoxy-phenyl)-...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of binding to Zap70 protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103788((5-{2-[1-(3-Carbamoyl-4-cyclohexylmethoxy-phenyl)-...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of binding to Src SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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