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Found 67 with Last Name = 'ruppert' and Initial = 'd'
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045686(4-(4-Amino-piperidin-1-yl)-N-[1-(1-cyclohexylmethy...)
Affinity DataIC50:  0.130nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045691(CHEMBL94827 | Methyl-{2-[methyl-(morpholine-4-carb...)
Affinity DataIC50:  0.160nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045691(CHEMBL94827 | Methyl-{2-[methyl-(morpholine-4-carb...)
Affinity DataIC50:  0.160nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045687(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-...)
Affinity DataIC50:  0.170nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  0.240nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045685(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  0.25nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045685(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  0.260nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045692(3-(4-Amino-cyclohexanesulfonyl)-2-benzyl-N-[1-(1-c...)
Affinity DataIC50:  0.310nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045692(3-(4-Amino-cyclohexanesulfonyl)-2-benzyl-N-[1-(1-c...)
Affinity DataIC50:  0.310nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045693(4-Amino-piperidine-1-carboxylic acid 1-[1-(1-cyclo...)
Affinity DataIC50:  0.370nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045693(4-Amino-piperidine-1-carboxylic acid 1-[1-(1-cyclo...)
Affinity DataIC50:  0.370nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  0.380nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  0.390nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045687(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-...)
Affinity DataIC50:  0.430nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045681(4-Amino-cyclohexanecarboxylic acid {1-[1-(1-cycloh...)
Affinity DataIC50:  0.470nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50282499(Bis-((R)-1-{(S)-3-methyl-2-[(S)-3-(2-methyl-propan...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity if the compound was determined against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045681(4-Amino-cyclohexanecarboxylic acid {1-[1-(1-cycloh...)
Affinity DataIC50:  0.5nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50282499(Bis-((R)-1-{(S)-3-methyl-2-[(S)-3-(2-methyl-propan...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity if the compound was determined against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045684(3-(4-Amino-piperidine-1-sulfonyl)-2-benzyl-N-[1-(1...)
Affinity DataIC50:  0.540nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045682(2-[4-(4-Amino-piperidin-1-yl)-2-benzyl-4-oxo-butyr...)
Affinity DataIC50:  0.680nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045688(5-{1-[1-(1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridi...)
Affinity DataIC50:  0.690nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045684(3-(4-Amino-piperidine-1-sulfonyl)-2-benzyl-N-[1-(1...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045688(5-{1-[1-(1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridi...)
Affinity DataIC50:  0.75nMAssay Description:Selectivity against rhesus monkey plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045686(4-(4-Amino-piperidin-1-yl)-N-[1-(1-cyclohexylmethy...)
Affinity DataIC50:  0.790nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50282495(Bis-((R)-1-{(S)-3-methyl-2-[(S)-3-(2-methyl-propan...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity if the compound was determined against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50282495(Bis-((R)-1-{(S)-3-methyl-2-[(S)-3-(2-methyl-propan...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity if the compound was determined against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50282500(({(S)-3-Methyl-2-[2-((S)-2-methyl-propane-2-sulfon...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity if the compound was determined against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045690(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-...)
Affinity DataIC50:  1.10nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045690(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-...)
Affinity DataIC50:  1.10nMAssay Description:Selectivity against guinea pig plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045682(2-[4-(4-Amino-piperidin-1-yl)-2-benzyl-4-oxo-butyr...)
Affinity DataIC50:  1.30nMAssay Description:Selectivity against sheep plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50008524(CHEMBL152610 | Methyl-{2-[methyl-(morpholine-4-car...)
Affinity DataIC50:  1.5nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50008524(CHEMBL152610 | Methyl-{2-[methyl-(morpholine-4-car...)
Affinity DataIC50:  2.40nMAssay Description:Concentration required for 50% inhibition of human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045689(4-Amino-cyclohexanecarboxylic acid [1-[1-(1-cycloh...)
Affinity DataIC50:  4.20nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50008520(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3,4,5,6-pentah...)
Affinity DataIC50:  4.40nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50008520(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3,4,5,6-pentah...)
Affinity DataIC50:  4.5nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045689(4-Amino-cyclohexanecarboxylic acid [1-[1-(1-cycloh...)
Affinity DataIC50:  5.30nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  5.5nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50282496(Bis-({(S)-3-methyl-2-[(S)-3-(2-methyl-propane-2-su...)
Affinity DataIC50:  5.5nMAssay Description:Inhibitory activity if the compound was determined against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50282498(Bis-({(S)-3-methyl-2-[(S)-3-(2-methyl-propane-2-su...)
Affinity DataIC50:  8.5nMAssay Description:Inhibitory activity if the compound was determined against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50008520(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3,4,5,6-pentah...)
Affinity DataIC50:  11nMAssay Description:Concentration required for 50% inhibition of human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50008522(4-Amino-cyclohexanecarboxylic acid {1-[1-(1-cycloh...)
Affinity DataIC50:  12nMAssay Description:Concentration required for 50% inhibition of human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  15nMAssay Description:Selectivity against dog plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50008522(4-Amino-cyclohexanecarboxylic acid {1-[1-(1-cycloh...)
Affinity DataIC50:  22nMAssay Description:Concentration required for 50% inhibition of sheep plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50230367(CHEMBL3143442)
Affinity DataIC50:  50nMAssay Description:Concentration required for 50% inhibition of rhesus monkey plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50008520(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3,4,5,6-pentah...)
Affinity DataIC50:  100nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50230367(CHEMBL3143442)
Affinity DataIC50:  110nMAssay Description:Concentration required for 50% inhibition of human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50008520(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3,4,5,6-pentah...)
Affinity DataIC50:  110nMAssay Description:Concentration required for 50% inhibition of dog plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50230366(CHEMBL3143445)
Affinity DataIC50:  120nMAssay Description:Concentration required for 50% inhibition of human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283567(4,6-Dibenzyl-5-hydroxy-1,3-bis-(4-hydroxymethyl-be...)
Affinity DataIC50:  240nMAssay Description:Inhibitory activity of the compound was evaluated against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
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