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Found 31 with Last Name = 'wataya' and Initial = 'y'
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50022238((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...)
Affinity DataKi:  0.00100nM Kd:  0.00100nMAssay Description:Binding affinity to amethopterin-resistant Lactobacillus casei thymidylate synthetase in presence of cofactor permitting covalent bond formationMore data for this Ligand-Target Pair
TargetThymidylate synthase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50022238((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...)
Affinity DataKi:  10nMAssay Description:Compound was evaluated for the inhibition of dTMP synthetase with respect to dUMP.More data for this Ligand-Target Pair
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50022238((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...)
Affinity DataKi:  14nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed dTMP formation using dUMP as substrate by spectrophotometri...More data for this Ligand-Target Pair
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50016806(CHEMBL1236552)
Affinity DataKi:  17nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed dTMP formation using dUMP as substrate by spectrophotometri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50010236(CHEMBL3144200)
Affinity DataKi:  39nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed dTMP formation using dUMP as substrate by spectrophotometri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50135288((1S,2R,3S,4R)-4-(6-Amino-purin-9-yl)-cyclopentane-...)
Affinity DataKi:  160nMAssay Description:Inhibitory activity of the compound against human S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Plasmodium falciparum 3D7)
Gifu University

Curated by ChEMBL
LigandPNGBDBM50135288((1S,2R,3S,4R)-4-(6-Amino-purin-9-yl)-cyclopentane-...)
Affinity DataKi:  180nMAssay Description:Inhibitory activity of the compound against P. falciparum S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50010239(CHEMBL1236538)
Affinity DataKi:  190nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed dTMP formation using dUMP as substrate by spectrophotometri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50367027(CHEMBL603555)
Affinity DataKi:  250nMAssay Description:Compound was evaluated for the inhibition of dTMP synthetase with respect to dUMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Plasmodium falciparum 3D7)
Gifu University

Curated by ChEMBL
LigandPNGBDBM50135289((1S,2R,3S,4R)-4-(6-Amino-2-fluoro-purin-9-yl)-cycl...)
Affinity DataKi:  480nMAssay Description:Inhibitory activity of the compound against human S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50010238(CHEMBL1160593)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed dTMP formation using dUMP as substrate by spectrophotometri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50010242(CHEMBL1160594)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed dTMP formation using dUMP as substrate by spectrophotometri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50186267(2'-deoxy-5'-uridylic acid | CHEMBL211312 | dUMP)
Affinity DataKi:  2.26E+3nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed 5-BrdUMP dehalogenation by absorbance analysis in absence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50016805(CHEMBL3274191)
Affinity DataKi:  3.90E+3nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed 5-BrdUMP dehalogenation by absorbance analysis in absence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50135289((1S,2R,3S,4R)-4-(6-Amino-2-fluoro-purin-9-yl)-cycl...)
Affinity DataKi:  7.90E+3nMAssay Description:Inhibitory activity of the compound against human S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50016805(CHEMBL3274191)
Affinity DataKi:  8.30E+3nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed dTMP formation using dUMP as substrate by spectrophotometri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000965(CHEMBL3228982)
Affinity DataKi:  8.60E+3nMAssay Description:Competitive inhibition of thymidylate synthetase (unknown origin) in presence of 5,10-methylenetetrahydrofolateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50332929(((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-di...)
Affinity DataKi:  8.69E+3nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed 5-BrdUMP dehalogenation by absorbance analysis in absence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50010239(CHEMBL1236538)
Affinity DataKi:  9.39E+3nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed 5-BrdUMP dehalogenation by absorbance analysis in absence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50022238((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...)
Affinity DataKi:  1.49E+4nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed 5-BrdUMP dehalogenation by absorbance analysis in absence o...More data for this Ligand-Target Pair
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50332929(((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-di...)
Affinity DataKi:  1.55E+4nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed dTMP formation using dUMP as substrate by spectrophotometri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetThymidylate synthase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50221257(4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-(...)
Affinity DataKi:  1.60E+4nMAssay Description:Compound was evaluated for the inhibition of dTMP synthetase with respect to dUMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50367025(CHEMBL603336)
Affinity DataKi:  3.00E+4nMAssay Description:Compound was evaluated for the inhibition of dTMP synthetase with respect to dUMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50421668(CHEMBL2311177)
Affinity DataKi:  1.20E+5nMAssay Description:Compound was evaluated for the inhibition of dTMP synthetase with respect to dUMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50367024(CHEMBL606019)
Affinity DataKi:  2.30E+5nMAssay Description:Compound was evaluated for the inhibition of dTMP synthetase with respect to dUMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50135288((1S,2R,3S,4R)-4-(6-Amino-purin-9-yl)-cyclopentane-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory activity of the compound against human S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Plasmodium falciparum 3D7)
Gifu University

Curated by ChEMBL
LigandPNGBDBM50135288((1S,2R,3S,4R)-4-(6-Amino-purin-9-yl)-cyclopentane-...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibitory activity of the compound against P. falciparum S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Plasmodium falciparum 3D7)
Gifu University

Curated by ChEMBL
LigandPNGBDBM50135289((1S,2R,3S,4R)-4-(6-Amino-2-fluoro-purin-9-yl)-cycl...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibitory activity of the compound against P. falciparum S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50135289((1S,2R,3S,4R)-4-(6-Amino-2-fluoro-purin-9-yl)-cycl...)
Affinity DataIC50:  6.30E+4nMAssay Description:Inhibitory activity of the compound against P. falciparum S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50022238((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...)
Affinity DataKd:  10nMAssay Description:Binding affinity to amethopterin-resistant Lactobacillus casei thymidylate synthetase in presence of cofactor not permitting covalent bond formationMore data for this Ligand-Target Pair
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000965(CHEMBL3228982)
Affinity DataKd:  2.50E+4nMAssay Description:Binding affinity to thymidylate synthetase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed