Compile Data Set for Download or QSAR
maximum 50k data
Found 40 Enz. Inhib. hit(s) with all data for entry = 50032558
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50143282((-)-cytisine | (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...)
Affinity DataKi:  1.53nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331016(6-benzyl-3-(pyridin-3-yl)-6-azabicyclo[3.2.2]non-2...)
Affinity DataKi:  1.95nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]epibatidine from alpha7 nAChR in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331014(9-methyl-3-(pyridin-3-yl)-9-azabicyclo[3.3.1]non-2...)
Affinity DataKi:  10.4nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  11.1nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331017(3-(6-benzyl-6-azabicyclo[3.2.1]oct-3-en-3-yl)quino...)
Affinity DataKi:  29.3nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331016(6-benzyl-3-(pyridin-3-yl)-6-azabicyclo[3.2.2]non-2...)
Affinity DataKi:  170nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50143282((-)-cytisine | (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...)
Affinity DataKi:  203nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331014(9-methyl-3-(pyridin-3-yl)-9-azabicyclo[3.3.1]non-2...)
Affinity DataKi:  241nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331012(1-(9-azabicyclo[3.3.1]nonan-3-yl)indolin-2-one | C...)
Affinity DataKi:  422nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331015(3-(9-methyl-9-azabicyclo[3.3.1]non-2-en-3-yl)quino...)
Affinity DataKi:  423nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331016(6-benzyl-3-(pyridin-3-yl)-6-azabicyclo[3.2.2]non-2...)
Affinity DataKi:  424nMAssay Description:Displacement of [3H]epibatidine from alpha7 nAChR in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  481nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331011(1-(1-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indol...)
Affinity DataKi:  508nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331018(1-(6-benzyl-6-azabicyclo[3.2.1]octan-3-yl)indolin-...)
Affinity DataKi:  1.84E+3nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331017(3-(6-benzyl-6-azabicyclo[3.2.1]oct-3-en-3-yl)quino...)
Affinity DataKi:  2.48E+3nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331015(3-(9-methyl-9-azabicyclo[3.3.1]non-2-en-3-yl)quino...)
Affinity DataKi:  2.62E+3nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331010(1-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)indolin-...)
Affinity DataKi:  2.79E+3nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331013(CHEMBL1276233 | ethyl 3-(pyridin-3-yl)-9-azabicycl...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331009(3-(1-(4-tert-pentylcyclohexyl)piperidin-4-yl)indol...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331008(1-(1-benzyl-3-methylpiperidin-4-yl)indolin-2-one |...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331019(1-(6-methyl-6-azabicyclo[3.2.1]octan-3-yl)indolin-...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331013(CHEMBL1276233 | ethyl 3-(pyridin-3-yl)-9-azabicycl...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331009(3-(1-(4-tert-pentylcyclohexyl)piperidin-4-yl)indol...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331008(1-(1-benzyl-3-methylpiperidin-4-yl)indolin-2-one |...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50147744(1-{1-[1-(4-Cyclohexyl-phenyl)-ethyl]-piperidin-4-y...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50147744(1-{1-[1-(4-Cyclohexyl-phenyl)-ethyl]-piperidin-4-y...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331019(1-(6-methyl-6-azabicyclo[3.2.1]octan-3-yl)indolin-...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331018(1-(6-benzyl-6-azabicyclo[3.2.1]octan-3-yl)indolin-...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331011(1-(1-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indol...)
Affinity DataKi:  1.00E+5nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331011(1-(1-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indol...)
Affinity DataKi:  1.00E+5nMAssay Description:Displacement of [3H]epibatidine from alpha7 nAChR in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331010(1-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)indolin-...)
Affinity DataKi:  1.00E+5nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331012(1-(9-azabicyclo[3.3.1]nonan-3-yl)indolin-2-one | C...)
Affinity DataKi:  1.00E+5nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331011(1-(1-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indol...)
Affinity DataIC50:  1.02E+4nMAssay Description:Antagonist activity at rat alpha3beta4 nAChR expressed in HEK292 cells assessed as inhibition of epibatidine-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331011(1-(1-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indol...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat alpha3beta4 nAChR expressed in HEK292 cells assessed as increase of calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331014(9-methyl-3-(pyridin-3-yl)-9-azabicyclo[3.3.1]non-2...)
Affinity DataEC50:  4.80E+3nMAssay Description:Partial agonist activity at rat alpha3beta4 nAChR expressed in HEK292 cells assessed as increase of calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331016(6-benzyl-3-(pyridin-3-yl)-6-azabicyclo[3.2.2]non-2...)
Affinity DataEC50:  2.00E+3nMAssay Description:Partial agonist activity at rat alpha3beta4 nAChR expressed in HEK292 cells assessed as increase of calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataEC50:  16nMAssay Description:Agonist activity at rat alpha3beta4 nAChR expressed in HEK292 cells assessed as increase of calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed