Compile Data Set for Download or QSAR
Found 267 Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 1F'
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM21395(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1
Show InChI InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)
Affinity DataKi:  1.25nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130461(4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C21H22FN3O/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15/h2-7,12-14,23H,8-11H2,1H3,(H,24,26)
Affinity DataKi:  1.60nMAssay Description:Binding affinity at human 5HT1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50106483(4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-indol-4...)
Show SMILES CN1CCC(CC1)c1c[nH]c2cccc(NC(=O)c3ccc(F)cc3)c12
Show InChI InChI=1S/C21H22FN3O/c1-25-11-9-14(10-12-25)17-13-23-18-3-2-4-19(20(17)18)24-21(26)15-5-7-16(22)8-6-15/h2-8,13-14,23H,9-12H2,1H3,(H,24,26)
Affinity DataKi:  1.60nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130461(4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C21H22FN3O/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15/h2-7,12-14,23H,8-11H2,1H3,(H,24,26)
Affinity DataKi:  1.60nMAssay Description:In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130461(4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C21H22FN3O/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15/h2-7,12-14,23H,8-11H2,1H3,(H,24,26)
Affinity DataKi:  2.10nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130461(4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C21H22FN3O/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15/h2-7,12-14,23H,8-11H2,1H3,(H,24,26)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to human 5HT1F receptor by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130461(4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C21H22FN3O/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15/h2-7,12-14,23H,8-11H2,1H3,(H,24,26)
Affinity DataKi:  2.10nMAssay Description:In vitro binding affinity for human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50156407(4-Fluoro-N-[1-(1-methyl-piperidin-4-yl)-1H-indol-6...)
Show SMILES CN1CCC(CC1)n1ccc2ccc(NC(=O)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C21H22FN3O/c1-24-11-9-19(10-12-24)25-13-8-15-4-7-18(14-20(15)25)23-21(26)16-2-5-17(22)6-3-16/h2-8,13-14,19H,9-12H2,1H3,(H,23,26)
Affinity DataKi:  2.20nMAssay Description:In vitro binding affinity for human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50137539(2,4,6-Trifluoro-N-[3-(1-methyl-piperidin-4-yl)-fur...)
Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3c(F)cc(F)cc3F)nc12
Show InChI InChI=1S/C20H18F3N3O2/c1-26-6-4-11(5-7-26)13-10-28-16-2-3-17(24-19(13)16)25-20(27)18-14(22)8-12(21)9-15(18)23/h2-3,8-11H,4-7H2,1H3,(H,24,25,27)
Affinity DataKi:  2.30nMAssay Description:In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130471(1-Methyl-3-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo...)
Show SMILES CNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
Show InChI InChI=1S/C15H21N5O/c1-16-15(21)19-13-4-3-12-14(18-13)11(9-17-12)10-5-7-20(2)8-6-10/h3-4,9-10,17H,5-8H2,1-2H3,(H2,16,18,19,21)
Affinity DataKi:  2.5nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50159187(3-Chloro-N-[3-((R)-1-methyl-pyrrolidin-2-ylmethyl)...)
Show SMILES CN1CCCC1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12
Show InChI InChI=1S/C20H22ClN3O2S/c1-24-9-3-5-17(24)10-14-13-22-20-8-7-16(12-19(14)20)23-27(25,26)18-6-2-4-15(21)11-18/h2,4,6-8,11-13,17,22-23H,3,5,9-10H2,1H3
Affinity DataKi:  2.70nMAssay Description:Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50137540(2-Chloro-6-fluoro-N-[3-(1-methyl-piperidin-4-yl)-f...)
Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3c(F)cccc3Cl)nc12
Show InChI InChI=1S/C20H19ClFN3O2/c1-25-9-7-12(8-10-25)13-11-27-16-5-6-17(23-19(13)16)24-20(26)18-14(21)3-2-4-15(18)22/h2-6,11-12H,7-10H2,1H3,(H,23,24,26)
Affinity DataKi:  2.90nMAssay Description:In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50137538(2-Chloro-4-fluoro-N-[3-(1-methyl-piperidin-4-yl)-f...)
Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3ccc(F)cc3Cl)nc12
Show InChI InChI=1S/C20H19ClFN3O2/c1-25-8-6-12(7-9-25)15-11-27-17-4-5-18(23-19(15)17)24-20(26)14-3-2-13(22)10-16(14)21/h2-5,10-12H,6-9H2,1H3,(H,23,24,26)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50137541(4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-furo[3,2-b...)
Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3ccc(F)cc3)nc12
Show InChI InChI=1S/C20H20FN3O2/c1-24-10-8-13(9-11-24)16-12-26-17-6-7-18(22-19(16)17)23-20(25)14-2-4-15(21)5-3-14/h2-7,12-13H,8-11H2,1H3,(H,22,23,25)
Affinity DataKi:  3.10nMAssay Description:Concentration required for stimulation of [35S]-GTP-gammaS, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50091438((E)-3-(3,4-Dichloro-phenyl)-N-{5-[4-(5-hydroxy-1H-...)
Show SMILES Oc1ccc2[nH]cc(C3CCN(CCCCCNC(=O)\C=C\c4ccc(Cl)c(Cl)c4)CC3)c2c1
Show InChI InChI=1S/C27H31Cl2N3O2/c28-24-7-4-19(16-25(24)29)5-9-27(34)30-12-2-1-3-13-32-14-10-20(11-15-32)23-18-31-26-8-6-21(33)17-22(23)26/h4-9,16-18,20,31,33H,1-3,10-15H2,(H,30,34)/b9-5+
Affinity DataKi:  3.20nMAssay Description:Binding affinity for 5-hydroxytryptamine 1F receptor was determinedMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50156409(2-Chloro-4-fluoro-N-[3-(1-methyl-piperidin-4-yl)-b...)
Show SMILES CN1CCC(CC1)c1noc2ccc(NC(=O)c3ccc(F)cc3Cl)cc12
Show InChI InChI=1S/C20H19ClFN3O2/c1-25-8-6-12(7-9-25)19-16-11-14(3-5-18(16)27-24-19)23-20(26)15-4-2-13(22)10-17(15)21/h2-5,10-12H,6-9H2,1H3,(H,23,26)
Affinity DataKi:  3.60nMAssay Description:In vitro binding affinity for human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130422(1-Ethyl-3-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[...)
Show SMILES CCNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
Show InChI InChI=1S/C16H23N5O/c1-3-17-16(22)20-14-5-4-13-15(19-14)12(10-18-13)11-6-8-21(2)9-7-11/h4-5,10-11,18H,3,6-9H2,1-2H3,(H2,17,19,20,22)
Affinity DataKi:  3.80nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50106484(CHEMBL421287 | N-[3-(2-Dimethylamino-ethyl)-1H-ind...)
Show SMILES CN(C)CCc1c[nH]c2cccc(NC(=O)c3ccc(F)cc3)c12
Show InChI InChI=1S/C19H20FN3O/c1-23(2)11-10-14-12-21-16-4-3-5-17(18(14)16)22-19(24)13-6-8-15(20)9-7-13/h3-9,12,21H,10-11H2,1-2H3,(H,22,24)
Affinity DataKi:  3.80nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50156410(4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-indazol...)
Show SMILES CN1CCC(CC1)c1n[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C20H21FN4O/c1-25-10-8-13(9-11-25)19-17-12-16(6-7-18(17)23-24-19)22-20(26)14-2-4-15(21)5-3-14/h2-7,12-13H,8-11H2,1H3,(H,22,26)(H,23,24)
Affinity DataKi:  3.90nMAssay Description:In vitro binding affinity for human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50106249(CHEMBL92139 | [2-(1-Benzenesulfonyl-1H-indol-4-yl)...)
Show SMILES CN(C)CCc1cccc2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H20N2O2S/c1-19(2)13-11-15-7-6-10-18-17(15)12-14-20(18)23(21,22)16-8-4-3-5-9-16/h3-10,12,14H,11,13H2,1-2H3
Affinity DataKi:  3.90nMAssay Description:Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]-5-HT radioligandMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29)
Affinity DataKi:  3.98nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130468(2,4-Dichloro-N-[3-(1-methyl-piperidin-4-yl)-1H-pyr...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(Cl)cc3Cl)nc12
Show InChI InChI=1S/C20H20Cl2N4O/c1-26-8-6-12(7-9-26)15-11-23-17-4-5-18(24-19(15)17)25-20(27)14-3-2-13(21)10-16(14)22/h2-5,10-12,23H,6-9H2,1H3,(H,24,25,27)
Affinity DataKi:  4.10nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50156411(4-Fluoro-N-[1-(1-methyl-piperidin-4-yl)-1H-indazol...)
Show SMILES CN1CCC(CC1)n1ncc2ccc(NC(=O)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C20H21FN4O/c1-24-10-8-18(9-11-24)25-19-12-17(7-4-15(19)13-22-25)23-20(26)14-2-5-16(21)6-3-14/h2-7,12-13,18H,8-11H2,1H3,(H,23,26)
Affinity DataKi:  4.10nMAssay Description:In vitro binding affinity for human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130439(CHEMBL102250 | Furan-3-carboxylic acid [3-(1-methy...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccoc3)nc12
Show InChI InChI=1S/C18H20N4O2/c1-22-7-4-12(5-8-22)14-10-19-15-2-3-16(20-17(14)15)21-18(23)13-6-9-24-11-13/h2-3,6,9-12,19H,4-5,7-8H2,1H3,(H,20,21,23)
Affinity DataKi:  4.60nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130466(CHEMBL105556 | Methanesulfonic acid 3-(1-methyl-pi...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(OS(C)(=O)=O)nc12
Show InChI InChI=1S/C14H19N3O3S/c1-17-7-5-10(6-8-17)11-9-15-12-3-4-13(16-14(11)12)20-21(2,18)19/h3-4,9-10,15H,5-8H2,1-2H3
Affinity DataKi:  4.70nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50156404(4-Fluoro-N-[1-(1-methyl-piperidin-4-yl)-2,3-dihydr...)
Show SMILES CN1CCC(CC1)N1CCc2ccc(NC(=O)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C21H24FN3O/c1-24-11-9-19(10-12-24)25-13-8-15-4-7-18(14-20(15)25)23-21(26)16-2-5-17(22)6-3-16/h2-7,14,19H,8-13H2,1H3,(H,23,26)
Affinity DataKi:  4.80nMAssay Description:In vitro binding affinity for human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130448(CHEMBL431041 | N-[3-(1-Methyl-piperidin-4-yl)-1H-p...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(C)=O)nc12
Show InChI InChI=1S/C15H20N4O/c1-10(20)17-14-4-3-13-15(18-14)12(9-16-13)11-5-7-19(2)8-6-11/h3-4,9,11,16H,5-8H2,1-2H3,(H,17,18,20)
Affinity DataKi:  5nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50119543(CHEMBL3617549)
Show SMILES CN1CCC(CC1)C(=O)c1cccc(NC(=O)c2ccc(F)cc2)c1
Show InChI InChI=1S/C20H21FN2O2/c1-23-11-9-14(10-12-23)19(24)16-3-2-4-18(13-16)22-20(25)15-5-7-17(21)8-6-15/h2-8,13-14H,9-12H2,1H3,(H,22,25)
Affinity DataKi:  5.10nMAssay Description:Binding affinity to human 5HT1F receptor by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130426(CHEMBL105261 | N-[3-(1-Methyl-piperidin-4-yl)-1H-p...)
Show SMILES CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
Show InChI InChI=1S/C16H22N4O/c1-3-15(21)18-14-5-4-13-16(19-14)12(10-17-13)11-6-8-20(2)9-7-11/h4-5,10-11,17H,3,6-9H2,1-2H3,(H,18,19,21)
Affinity DataKi:  5.5nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130436(3-Methyl-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3cccc(C)c3)nc12
Show InChI InChI=1S/C21H24N4O/c1-14-4-3-5-16(12-14)21(26)24-19-7-6-18-20(23-19)17(13-22-18)15-8-10-25(2)11-9-15/h3-7,12-13,15,22H,8-11H2,1-2H3,(H,23,24,26)
Affinity DataKi:  5.80nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM85195(CAS_5311097 | LY 344864 | NSC_5311097)
Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1
Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26)
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130442(CHEMBL105722 | Pyridine-2-carboxylic acid [3-(1-me...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccccn3)nc12
Show InChI InChI=1S/C19H21N5O/c1-24-10-7-13(8-11-24)14-12-21-15-5-6-17(22-18(14)15)23-19(25)16-4-2-3-9-20-16/h2-6,9,12-13,21H,7-8,10-11H2,1H3,(H,22,23,25)
Affinity DataKi:  6.30nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(MOUSE)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50031942((6aR,9R)-4,6a,7-Trimethyl-4,6,6a,7,8,9-hexahydro-i...)
Show SMILES CC[C@@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2Cc3cn(C)c4cccc(C2=C1)c34
Show InChI InChI=1S/C21H27N3O2/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26)/t14-,15+,19-/m1/s1
Affinity DataKi:  6.30nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130465(CHEMBL105955 | N-[3-(1-Methyl-piperidin-4-yl)-1H-p...)
Show SMILES CCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
Show InChI InChI=1S/C17H24N4O/c1-3-4-16(22)19-15-6-5-14-17(20-15)13(11-18-14)12-7-9-21(2)10-8-12/h5-6,11-12,18H,3-4,7-10H2,1-2H3,(H,19,20,22)
Affinity DataKi:  6.90nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130467(CHEMBL321080 | Thiophene-2-carboxylic acid [3-(1-m...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3cccs3)nc12
Show InChI InChI=1S/C18H20N4OS/c1-22-8-6-12(7-9-22)13-11-19-14-4-5-16(20-17(13)14)21-18(23)15-3-2-10-24-15/h2-5,10-12,19H,6-9H2,1H3,(H,20,21,23)
Affinity DataKi:  7.10nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130432(4-Cyano-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(cc3)C#N)nc12
Show InChI InChI=1S/C21H21N5O/c1-26-10-8-15(9-11-26)17-13-23-18-6-7-19(24-20(17)18)25-21(27)16-4-2-14(12-22)3-5-16/h2-7,13,15,23H,8-11H2,1H3,(H,24,25,27)
Affinity DataKi:  7.20nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130445(CHEMBL105743 | N-[3-(1-Methyl-piperidin-4-yl)-1H-p...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccccc3)nc12
Show InChI InChI=1S/C20H22N4O/c1-24-11-9-14(10-12-24)16-13-21-17-7-8-18(22-19(16)17)23-20(25)15-5-3-2-4-6-15/h2-8,13-14,21H,9-12H2,1H3,(H,22,23,25)
Affinity DataKi:  7.30nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130447(CHEMBL104753 | Thiophene-3-carboxylic acid [3-(1-m...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccsc3)nc12
Show InChI InChI=1S/C18H20N4OS/c1-22-7-4-12(5-8-22)14-10-19-15-2-3-16(20-17(14)15)21-18(23)13-6-9-24-11-13/h2-3,6,9-12,19H,4-5,7-8H2,1H3,(H,20,21,23)
Affinity DataKi:  7.40nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130463(4-Fluoro-benzenesulfonic acid 3-(1-methyl-piperidi...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(OS(=O)(=O)c3ccc(F)cc3)nc12
Show InChI InChI=1S/C19H20FN3O3S/c1-23-10-8-13(9-11-23)16-12-21-17-6-7-18(22-19(16)17)26-27(24,25)15-4-2-14(20)3-5-15/h2-7,12-13,21H,8-11H2,1H3
Affinity DataKi:  7.5nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130443(4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(F)cc3)nc12
Show InChI InChI=1S/C20H21FN4O/c1-25-10-8-13(9-11-25)16-12-22-17-6-7-18(23-19(16)17)24-20(26)14-2-4-15(21)5-3-14/h2-7,12-13,22H,8-11H2,1H3,(H,23,24,26)
Affinity DataKi:  7.60nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130443(4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(F)cc3)nc12
Show InChI InChI=1S/C20H21FN4O/c1-25-10-8-13(9-11-25)16-12-22-17-6-7-18(23-19(16)17)24-20(26)14-2-4-15(21)5-3-14/h2-7,12-13,22H,8-11H2,1H3,(H,23,24,26)
Affinity DataKi:  7.60nMAssay Description:In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130451(CHEMBL104692 | N-[3-(1-Methyl-piperidin-4-yl)-1H-p...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(cc3)[N+]([O-])=O)nc12
Show InChI InChI=1S/C20H21N5O3/c1-24-10-8-13(9-11-24)16-12-21-17-6-7-18(22-19(16)17)23-20(26)14-2-4-15(5-3-14)25(27)28/h2-7,12-13,21H,8-11H2,1H3,(H,22,23,26)
Affinity DataKi:  7.70nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50137542(CHEMBL178066 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Show SMILES CN(C)CCc1c(C)[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C20H22FN3O/c1-13-17(10-11-24(2)3)18-12-16(8-9-19(18)22-13)23-20(25)14-4-6-15(21)7-5-14/h4-9,12,22H,10-11H2,1-3H3,(H,23,25)
Affinity DataKi:  8.20nMAssay Description:In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50106482(CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Show SMILES CN(C)CCc1c(C)[nH]c2cccc(NC(=O)c3ccc(F)cc3)c12
Show InChI InChI=1S/C20H22FN3O/c1-13-16(11-12-24(2)3)19-17(22-13)5-4-6-18(19)23-20(25)14-7-9-15(21)10-8-14/h4-10,22H,11-12H2,1-3H3,(H,23,25)
Affinity DataKi:  8.20nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1F receptor using [3H]-5-HT radioligandMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50119542(CHEMBL3617550)
Show SMILES CN1CCC(CC1)C(=O)c1cccc(NC(=O)c2ccc(F)cc2)c1F
Show InChI InChI=1S/C20H20F2N2O2/c1-24-11-9-13(10-12-24)19(25)16-3-2-4-17(18(16)22)23-20(26)14-5-7-15(21)8-6-14/h2-8,13H,9-12H2,1H3,(H,23,26)
Affinity DataKi:  8.30nMAssay Description:Binding affinity to human 5HT1F receptor by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130437(CHEMBL105958 | N-[3-(1-Methyl-piperidin-4-yl)-1H-p...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccncc3)nc12
Show InChI InChI=1S/C19H21N5O/c1-24-10-6-13(7-11-24)15-12-21-16-2-3-17(22-18(15)16)23-19(25)14-4-8-20-9-5-14/h2-5,8-9,12-13,21H,6-7,10-11H2,1H3,(H,22,23,25)
Affinity DataKi:  8.40nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50156402(4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-2,3-dihydr...)
Show SMILES CN1CCC(CC1)C1CNc2ccc(NC(=O)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C21H24FN3O/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15/h2-7,12,14,19,23H,8-11,13H2,1H3,(H,24,26)
Affinity DataKi:  8.60nMAssay Description:In vitro binding affinity for human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130433(CHEMBL420475 | Cyclobutanecarboxylic acid [3-(1-me...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)C3CCC3)nc12
Show InChI InChI=1S/C18H24N4O/c1-22-9-7-12(8-10-22)14-11-19-15-5-6-16(20-17(14)15)21-18(23)13-3-2-4-13/h5-6,11-13,19H,2-4,7-10H2,1H3,(H,20,21,23)
Affinity DataKi:  8.70nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50156402(4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-2,3-dihydr...)
Show SMILES CN1CCC(CC1)C1CNc2ccc(NC(=O)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C21H24FN3O/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15/h2-7,12,14,19,23H,8-11,13H2,1H3,(H,24,26)
Affinity DataKi:  9nMAssay Description:In vitro binding affinity for human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50130449(4-Fluoro-N-(3-piperidin-4-yl-1H-pyrrolo[3,2-b]pyri...)
Show SMILES Fc1ccc(cc1)C(=O)Nc1ccc2[nH]cc(C3CCNCC3)c2n1
Show InChI InChI=1S/C19H19FN4O/c20-14-3-1-13(2-4-14)19(25)24-17-6-5-16-18(23-17)15(11-22-16)12-7-9-21-10-8-12/h1-6,11-12,21-22H,7-10H2,(H,23,24,25)
Affinity DataKi:  9.5nMAssay Description:In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
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