Compile Data Set for Download or QSAR
Report error Found 70 Enz. Inhib. hit(s) with all data for entry = 50021078
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220703((R)-N-((S)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...)
Affinity DataIC50: 0.850nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220703((R)-N-((S)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...)
Affinity DataEC50:  3.20nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220696((R)-N-((S)-3-(4-chlorophenyl)-1-(4-((1-methyl-1H-t...)
Affinity DataIC50: 3.60nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220689((R)-N-((S)-1-(4-sec-butyl-4-((1-methyl-1H-tetrazol...)
Affinity DataIC50: 3.70nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220689((R)-N-((S)-1-(4-sec-butyl-4-((1-methyl-1H-tetrazol...)
Affinity DataEC50:  3.90nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220700((R)-N-((S)-3-(4-chlorophenyl)-1-(4-hexyl-4-((1-met...)
Affinity DataIC50: 4nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220694((R)-N-((S)-3-(4-chlorophenyl)-1-(4-(4-chlorophenyl...)
Affinity DataEC50:  4.90nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220691((R)-N-((S)-3-(4-chlorophenyl)-1-(4-isobutyl-4-((1-...)
Affinity DataIC50: 6nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220710((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-cyclohexyl...)
Affinity DataEC50:  6.5nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220699((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-(4-methylc...)
Affinity DataIC50: 6.80nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220693((R)-N-((S)-3-(4-chlorophenyl)-1-(4-(cyanomethyl)-4...)
Affinity DataIC50: 6.80nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220699((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-(4-methylc...)
Affinity DataEC50:  10nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220691((R)-N-((S)-3-(4-chlorophenyl)-1-(4-isobutyl-4-((1-...)
Affinity DataEC50:  13nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220710((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-cyclohexyl...)
Affinity DataIC50: 14nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220711((R)-N-((S)-3-(4-chlorophenyl)-1-(4-(cyanomethyl)-4...)
Affinity DataIC50: 16nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220696((R)-N-((S)-3-(4-chlorophenyl)-1-(4-((1-methyl-1H-t...)
Affinity DataEC50:  21nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220690((R)-N-((S)-1-(4-butyl-4-(cyanomethyl)piperidin-1-y...)
Affinity DataIC50: 22nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220700((R)-N-((S)-3-(4-chlorophenyl)-1-(4-hexyl-4-((1-met...)
Affinity DataEC50:  29nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220702((R)-N-((S)-3-(4-chlorophenyl)-1-(4-((1-methyl-1H-t...)
Affinity DataIC50: 32nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220705((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-(1-methylc...)
Affinity DataIC50: 37nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220706((R)-N-((S)-1-(4-benzyl-4-((1-methyl-1H-tetrazol-5-...)
Affinity DataIC50: 52nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220705((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-(1-methylc...)
Affinity DataEC50:  58nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220698((R)-N-((S)-3-(4-chlorophenyl)-1-(4-(cyanomethyl)-4...)
Affinity DataIC50: 63nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220697((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-(cyclohex-...)
Affinity DataIC50: 64nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220701((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-tert-penty...)
Affinity DataIC50: 66nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220697((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-(cyclohex-...)
Affinity DataEC50:  85nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220706((R)-N-((S)-1-(4-benzyl-4-((1-methyl-1H-tetrazol-5-...)
Affinity DataEC50:  111nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220694((R)-N-((S)-3-(4-chlorophenyl)-1-(4-(4-chlorophenyl...)
Affinity DataIC50: 113nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220703((R)-N-((S)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...)
Affinity DataEC50:  115nMAssay Description:Antagonist activity at human MC3R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220701((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-tert-penty...)
Affinity DataEC50:  151nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220702((R)-N-((S)-3-(4-chlorophenyl)-1-(4-((1-methyl-1H-t...)
Affinity DataEC50:  157nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220688((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-(4,4-dimet...)
Affinity DataIC50: 162nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220708((R)-N-((S)-3-(4-chlorophenyl)-1-(4-(cyanomethyl)-4...)
Affinity DataIC50: 173nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220695((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-(cyclobuty...)
Affinity DataIC50: 177nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220693((R)-N-((S)-3-(4-chlorophenyl)-1-(4-(cyanomethyl)-4...)
Affinity DataEC50:  189nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220711((R)-N-((S)-3-(4-chlorophenyl)-1-(4-(cyanomethyl)-4...)
Affinity DataEC50:  196nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220703((R)-N-((S)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...)
Affinity DataEC50:  222nMAssay Description:Antagonist activity at human MC5R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220699((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-(4-methylc...)
Affinity DataEC50:  230nMAssay Description:Antagonist activity at human MC3R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220688((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-(4,4-dimet...)
Affinity DataEC50:  241nMAssay Description:Antagonist activity at human MC3R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220689((R)-N-((S)-1-(4-sec-butyl-4-((1-methyl-1H-tetrazol...)
Affinity DataEC50:  250nMAssay Description:Antagonist activity at human MC5R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220689((R)-N-((S)-1-(4-sec-butyl-4-((1-methyl-1H-tetrazol...)
Affinity DataEC50:  263nMAssay Description:Antagonist activity at human MC3R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220690((R)-N-((S)-1-(4-butyl-4-(cyanomethyl)piperidin-1-y...)
Affinity DataEC50:  281nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220707((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-(4-oxocycl...)
Affinity DataIC50: 343nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220696((R)-N-((S)-3-(4-chlorophenyl)-1-(4-((1-methyl-1H-t...)
Affinity DataEC50:  380nMAssay Description:Antagonist activity at human MC5R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220694((R)-N-((S)-3-(4-chlorophenyl)-1-(4-(4-chlorophenyl...)
Affinity DataEC50:  434nMAssay Description:Antagonist activity at human MC3R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220690((R)-N-((S)-1-(4-butyl-4-(cyanomethyl)piperidin-1-y...)
Affinity DataEC50:  480nMAssay Description:Antagonist activity at human MC5R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220694((R)-N-((S)-3-(4-chlorophenyl)-1-(4-(4-chlorophenyl...)
Affinity DataEC50:  527nMAssay Description:Antagonist activity at human MC5R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220688((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-(4,4-dimet...)
Affinity DataEC50:  546nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220695((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-(cyclobuty...)
Affinity DataEC50:  563nMAssay Description:Antagonist activity at human MC4R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50220711((R)-N-((S)-3-(4-chlorophenyl)-1-(4-(cyanomethyl)-4...)
Affinity DataEC50:  630nMAssay Description:Antagonist activity at human MC5R assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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