Compile Data Set for Download or QSAR
maximum 50k data
Found 119 Enz. Inhib. hit(s) with all data for entry = 50038969
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301109((5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenylpiperazine...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301116((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301103((2S,3S)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)ethy...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301119((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301101((2S,3S)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)ethy...)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301104((5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenyl-1,2,3,6-t...)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301118((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301114((2S,3S,5S)-methyl 3-(hydroxycarbamoyl)-2-(4-phenyl...)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301107(CHEMBL572301 | isopropyl-(5S,6S)-5-(hydroxycarbamo...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301104((5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenyl-1,2,3,6-t...)
Affinity DataIC50:  9nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301118((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301106((2S,3S)-N-hydroxy-5-(N-methylbenzamido)-2-(4-pheny...)
Affinity DataIC50:  10nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301110((5S,6S)-5-(hydroxycarbamoyl)-6-(3-phenyl-2,5-dihyd...)
Affinity DataIC50:  11nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301105((2S,3S)-N-hydroxy-5-(N-methylisobutyramido)-2-(4-p...)
Affinity DataIC50:  11nMAssay Description:Inhibition of MMP-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301107(CHEMBL572301 | isopropyl-(5S,6S)-5-(hydroxycarbamo...)
Affinity DataIC50:  11nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301109((5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenylpiperazine...)
Affinity DataIC50:  11nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301113((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50:  11.5nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301106((2S,3S)-N-hydroxy-5-(N-methylbenzamido)-2-(4-pheny...)
Affinity DataIC50:  12nMAssay Description:Inhibition of MMP-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301106((2S,3S)-N-hydroxy-5-(N-methylbenzamido)-2-(4-pheny...)
Affinity DataIC50:  12nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301101((2S,3S)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)ethy...)
Affinity DataIC50:  14nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301105((2S,3S)-N-hydroxy-5-(N-methylisobutyramido)-2-(4-p...)
Affinity DataIC50:  15.5nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301103((2S,3S)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)ethy...)
Affinity DataIC50:  17nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301113((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50:  18nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  18nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301114((2S,3S,5S)-methyl 3-(hydroxycarbamoyl)-2-(4-phenyl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301102((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301105((2S,3S)-N-hydroxy-5-(N-methylisobutyramido)-2-(4-p...)
Affinity DataIC50:  23nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301120((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50:  26nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301120((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50:  27.5nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50378414(CHEMBL1204013)
Affinity DataIC50:  28nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301123((2S,3S)-N-hydroxy-5-(N-methylbenzamido)-2-((R)-3-p...)
Affinity DataIC50:  29nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301116((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301121((3R,5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenyl-1,2,3,...)
Affinity DataIC50:  30nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301115((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50:  31nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  33nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301119((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50:  35nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301108((5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenylpiperidine...)
Affinity DataIC50:  42nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301102((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50:  44.5nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301117((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50:  50.5nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301122((2S,3S)-N-hydroxy-5-(N-methylisobutyramido)-2-((R)...)
Affinity DataIC50:  52nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301115((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50:  58nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301110((5S,6S)-5-(hydroxycarbamoyl)-6-(3-phenyl-2,5-dihyd...)
Affinity DataIC50:  60nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301112((5S,6S)-5-(hydroxycarbamoyl)-6-(isoindoline-2-carb...)
Affinity DataIC50:  70nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301121((3R,5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenyl-1,2,3,...)
Affinity DataIC50:  78nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378414(CHEMBL1204013)
Affinity DataIC50:  83nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301123((2S,3S)-N-hydroxy-5-(N-methylbenzamido)-2-((R)-3-p...)
Affinity DataIC50:  84nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50:  92nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50:  97nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50301108((5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenylpiperidine...)
Affinity DataIC50:  99nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50301104((5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenyl-1,2,3,6-t...)
Affinity DataIC50:  102nMAssay Description:Inhibition of MMP-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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