Compile Data Set for Download or QSAR
Report error Found 204 Enz. Inhib. hit(s) with all data for entry = 730
TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288560BDBM288560(4-[8-amino-1-(4-{[4- (trifluoromethyl) pyridin-2- ...)
Affinity DataIC50: 0.130nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288562BDBM288562(4-[8-amino-1-(2- fluoro-4-{[4- (trifluoromethyl) p...)
Affinity DataIC50: 0.160nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288442BDBM288442((1S,3S)-3-[8-amino-1- (4-{[4- (trifluoromethyl) py...)
Affinity DataIC50: 0.160nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288448BDBM288448({(1R,3R)-3-[8-amino- 1-(4-{[4- (trifluoromethyl) p...)
Affinity DataIC50: 0.160nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288528BDBM288528((1R,3R)-3-[8-amino- 1-(2-fluoro-4-{[4- (trifluorom...)
Affinity DataIC50: 0.170nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288447BDBM288447({(1S,3R)-3-[8-amino- 1-(4-{[4- (trifluoromethyl) p...)
Affinity DataIC50: 0.180nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288561BDBM288561(4-(8-amino-1-{4-[(4- cyclopropylpyridin-2- yl)carb...)
Affinity DataIC50: 0.190nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288463BDBM288463(4-(8-amino-1-(2- fluoro-4-((4- (trifluoromethyl) p...)
Affinity DataIC50: 0.200nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288461BDBM288461(5-[8-amino-1-(4-{[4- (trifluoromethyl) pyridin-2- ...)
Affinity DataIC50: 0.230nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288524BDBM288524((1R,3R)-3-[8-amino- 1-(2-chloro-4-{[4- (trifluorom...)
Affinity DataIC50: 0.25nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288443BDBM288443({(1R,3S)-3-[8-amino- 1-(4-{[4- (trifluoromethyl) p...)
Affinity DataIC50: 0.260nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288508BDBM288508((1S,3R)-3-[8-amino-1- (2-fluoro-6-methoxy- 4-{[4- ...)
Affinity DataIC50: 0.260nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288416BDBM288416(US10087188, Example 21)
Affinity DataIC50: 0.270nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288549BDBM288549((1R,3S)-3-[8-amino-1- (4-{[4- (trifluoromethyl) py...)
Affinity DataIC50: 0.280nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288563BDBM288563(4-[8-amino-1-(2- methoxy-4-{[4- (trifluoromethyl) ...)
Affinity DataIC50: 0.290nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288444BDBM288444({(1S,3S)-3-[8-amino- 1-(4-{[4- (trifluoromethyl) p...)
Affinity DataIC50: 0.290nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288529BDBM288529(US10087188, Example 137 | US10087188, Example 138 ...)
Affinity DataIC50: 0.340nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288564BDBM288564(4-[8-amino-1-(2- ethoxy-4-{[4- (trifluoromethyl) p...)
Affinity DataIC50: 0.340nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288518BDBM288518((1R,3R,5S,6r)-3-[8- amino-1-(4-{[4- (trifluorometh...)
Affinity DataIC50: 0.340nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288514BDBM288514((1S,3R)-3-(8-amino-1- {4-[(4- cyclopropylpyridin-2...)
Affinity DataIC50: 0.370nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288567BDBM288567(US10087188, Example 175)
Affinity DataIC50: 0.370nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288462BDBM288462((1S,3R)-3-[8-amino-1- (4-{[4- (trifluoromethyl) py...)
Affinity DataIC50: 0.370nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288532BDBM288532((1R,3r,5S,6s)-3-[8- amino-1-(4-{[4- (trifluorometh...)
Affinity DataIC50: 0.380nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288543BDBM288543(4-[8-amino-1-(2- chloro-4-{[4- (trifluoromethyl) p...)
Affinity DataIC50: 0.380nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288355BDBM288355((1S,3R)-3-[8- amino-1-(2- fluoro-4-{[4- (trifluoro...)
Affinity DataIC50: 0.390nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288429BDBM288429(3-[8-amino-1-(4-{[4- (trifluoromethyl) pyridin-2- ...)
Affinity DataIC50: 0.390nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288460BDBM288460(5-[8-amino-1-(2- ethoxy-4-{[4- (trifluoromethyl) p...)
Affinity DataIC50: 0.390nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 255336BDBM255336(US9481682, 86 | US10087188, Example 43)
Affinity DataIC50: 0.410nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288469BDBM288469(4-(8-amino-1-(4-((4- cyanopyridin-2- yl)carbamoyl)...)
Affinity DataIC50: 0.410nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288553BDBM288553(4-[8-amino-1-(2- hydroxy-4-{[4- (trifluoromethyl) ...)
Affinity DataIC50: 0.410nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288589BDBM288589(trans-4-{(2R,5S)-2-[8-amino- 5-chloro-1-(2-fluoro-...)
Affinity DataIC50: 0.420nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288527BDBM288527((1R,3R,5S,6r)-3-[8- amino-1-(2-ethoxy-4- {[4- (tri...)
Affinity DataIC50: 0.430nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288477BDBM288477((1S,3R)-3-[8-amino-1- (2-ethoxy-4-{[4- (trifluorom...)
Affinity DataIC50: 0.450nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288519BDBM288519((1S,3S)-3-[8-amino-1- (2-ethoxy-6-fluoro-4- {[4- (...)
Affinity DataIC50: 0.470nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288459BDBM288459(4-[8-amino-1-(2- ethoxy-4-{[4- (trifluoromethyl) p...)
Affinity DataIC50: 0.470nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288506BDBM288506((1S,3R)-3-[8-amino-1- (2-ethoxy-6-fluoro-4- {[4- (...)
Affinity DataIC50: 0.480nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288568BDBM288568(US10087188, Example 176)
Affinity DataIC50: 0.490nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288526BDBM288526(4-[8-amino-1-(2- fluoro-4-{[4- (trifluoromethyl) p...)
Affinity DataIC50: 0.5nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288485BDBM288485((1S,3S)-3-[8-amino-1- (2-chloro-4-{[4- (trifluorom...)
Affinity DataIC50: 0.510nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288486BDBM288486(6-[8-amino-1-(2- ethoxy-4-{[4- (trifluoromethyl) p...)
Affinity DataIC50: 0.510nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288308BDBM288308(US10087188, Example 1 | US10087188, Example 6)
Affinity DataIC50: 0.510nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288449BDBM288449((1R,2R,5R,6S)-2-[8- amino-1-(4-{[4- (trifluorometh...)
Affinity DataIC50: 0.520nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288496BDBM288496(4-[8-amino-1-(2- ethoxy-4-{[4- (trifluoromethyl) p...)
Affinity DataIC50: 0.520nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288467BDBM288467(4-(8-amino-1-(4-((4- cyclopropylpyridin-2- yl)carb...)
Affinity DataIC50: 0.540nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288493BDBM288493(5-[8-amino-1-(2- ethoxy-4-{[4- (trifluoromethyl) p...)
Affinity DataIC50: 0.540nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288468BDBM288468(4-(8-amino-1-(2- methoxy-4-((4- (trifluoromethyl) ...)
Affinity DataIC50: 0.560nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288582BDBM288582(trans-4-{(2R,5S)-2-[8-amino- 1-(2-fluoro-4-{[4- (t...)
Affinity DataIC50: 0.560nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288541BDBM288541(4-[8-amino-1-(2- ethoxy-5-fluoro-4-{[4- (trifluoro...)
Affinity DataIC50: 0.560nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288418BDBM288418(US10087188, Example 23)
Affinity DataIC50: 0.560nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 288516BDBM288516((1S,3S)-3-(8-amino-1- {4-[(4- cyclopropylpyridin-2...)
Affinity DataIC50: 0.570nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

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