Compile Data Set for Download or QSAR
Report error Found 2607 of affinity data for UniProtKB/TrEMBL: Q9H3N8
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127609(C-[2-(1H-Imidazol-4-yl)-cyclopropyl]-methylamine |...)
Affinity DataEC50: >0.000100nMAssay Description:Inhibition of human Histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127608(2-[2-(1H-Imidazol-4-yl)-cyclopropyl]-ethylamine | ...)
Affinity DataEC50: >0.000100nMAssay Description:Inhibition of human Histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127602(C-[2-(1H-Imidazol-4-yl)-cyclopropyl]-methylamine |...)
Affinity DataEC50: >0.000100nMAssay Description:Inhibition of human Histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127607(VUF-5296 | 2-(1H-Imidazol-4-yl)-cyclopropylamine |...)
Affinity DataEC50: >0.000100nMAssay Description:Inhibition of human Histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127605(VUF-5297 | (1S,2S)-2-(1H-Imidazol-4-yl)-cyclopropy...)
Affinity DataEC50: >0.000100nMAssay Description:Inhibition of human Histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127610((1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclo...)
Affinity DataEC50: >0.000100nMAssay Description:Inhibition of human Histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127603(C-[2-(1H-Imidazol-4-yl)-cyclopropyl]-methylamine |...)
Affinity DataEC50: >0.000100nMAssay Description:Inhibition of human Histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127606(2-(1H-Imidazol-4-yl)-cyclopropylamine | CHEMBL2940...)
Affinity DataEC50: >0.000100nMAssay Description:Inhibition of human Histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127604(C-[2-(1H-Imidazol-4-yl)-cyclopropyl]-methylamine |...)
Affinity DataEC50: >0.000100nMAssay Description:Inhibition of human Histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127601(2-(1H-Imidazol-4-yl)-cyclopropylamine | CHEMBL5938...)
Affinity DataEC50: >0.000100nMAssay Description:Inhibition of human Histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50356880(CHEMBL1915536)
Affinity DataKi:  0.0340nMAssay Description:Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50343025((R)-4-(3-(methylamino)pyrrolidin-1-yl)-N2-neopenty...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50356873(CHEMBL1914541)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50509072(CHEMBL4454158)
Affinity DataEC50:  0.123nMAssay Description:Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50343021((R)-N2-isobutyl-4-(3-(methylamino)pyrrolidin-1-yl)...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50319300(N-(2-(1H-imidazol-4-yl)ethyl)-3-(4-(5-fluoro-4-met...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50343018(4-(4-methylpiperazin-1-yl)-N2-neopentylpyridine-2,...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50356794(CHEMBL1914462)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50315348((R)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM335426(4-[(3R)-3-(Methylamino)pyrrolidin-1-yl]-N-[(1R,2R,...)
Affinity DataKi:  0.5nMAssay Description:Cell pellets from SK-N-MC cells stably or transiently transfected with human H4 receptor (NCBI accession No. AF312230) were used for the binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50319300(N-(2-(1H-imidazol-4-yl)ethyl)-3-(4-(5-fluoro-4-met...)
Affinity DataEC50:  0.560nMAssay Description:Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forsko...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50509078(CHEMBL4443126)
Affinity DataEC50:  0.603nMAssay Description:Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50356884(CHEMBL1915540)
Affinity DataIC50: 0.650nMAssay Description:Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50356815(CHEMBL1914781)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50356788(CHEMBL1914755)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50061017(CHEMBL3393547)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50315348((R)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50343023((R)-N2-cyclopentyl-4-(3-(methylamino)pyrrolidin-1-...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50006745(CHEMBL3236556)
Affinity DataKi:  0.920nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50121205(CHEBI:18295 | Histamine)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM22564(2-{2-chloro-4-[3-(4-methyl-1,4-diazepan-1-yl)propo...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50418058(CHEMBL1688946)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50342990(N4-cyclopentyl-6-(4-methylpiperazin-1-yl)pyrimidin...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM335425(4-[(3R)-3-(Methylamino)pyrrolidin-1-yl]-N-[(1S,2S,...)
Affinity DataKi:  1nMAssay Description:Cell pellets from SK-N-MC cells stably or transiently transfected with human H4 receptor (NCBI accession No. AF312230) were used for the binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50006742(CHEMBL3236553)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50061098(CHEMBL3393534 | US9732087, 1)
Affinity DataKi:  1nMAssay Description:Cell pellets from SK-N-MC cells stably or transiently transfected with human H4 receptor (NCBI accession No. AF312230) were used for the binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50356817(CHEMBL1914783)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50315348((R)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50061098(CHEMBL3393534 | US9732087, 1)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM22564(2-{2-chloro-4-[3-(4-methyl-1,4-diazepan-1-yl)propo...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 7.5 T: 2°CAssay Description:The Ki values were calculated based on an experimentally determined appropriate Kd value according to Cheng and Prusoff.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2008
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50061008(CHEMBL3393556 | US9732087, 96)
Affinity DataKi:  1nMAssay Description:Cell pellets from SK-N-MC cells stably or transiently transfected with human H4 receptor (NCBI accession No. AF312230) were used for the binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50356793(CHEMBL1914760)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50343007((R)-N2-isobutyl-6-(3-(methylamino)pyrrolidin-1-yl)...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50006743(CHEMBL3236554)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50356872(CHEMBL1914540)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50356874(CHEMBL1914542)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50317865(2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole |...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant histamine H4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50317865(2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole |...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50538682(CHEMBL4597218)
Affinity DataKi:  1.20nMAssay Description:Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50006742(CHEMBL3236553)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
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