BDBM90787 1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydrochloride::GUVACINE::Guvacine hydrochloride::MLS000859975::SMR000326834::cid_11957555

SMILES OC(=O)C1=CCCNC1

InChI Key InChIKey=QTDZOWFRBNTPQR-UHFFFAOYSA-N

Data  26 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 90787   

TargetCorticotropin-releasing factor-binding protein(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataEC50: >5.30E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human GAT1 expressed in COS cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  5.80E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Ludwig-Maximilians-University M£Nchen

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent betaine transporter(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  1.87E+6nMAssay Description:Inhibition of human GABA transporter (hBGT-1) activity.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  7.24E+4nMAssay Description:Inhibition of mouse GAT2 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  1.15E+5nMAssay Description:Inhibition of mouse GAT3 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  2.09E+4nMAssay Description:Inhibition of mouse GAT1 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent betaine transporter(Mouse)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of mouse BGT1 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Human)
Zentrum F£R Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  1.10E+5nMAssay Description:Binding affinity to GAT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Human)
Zentrum F£R Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  6.60E+4nMAssay Description:Binding affinity to GAT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  2.77E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  2.59E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  2.66E+3nMAssay Description:H-bonding interaction between amino acid residue (Thr-89) of Sodium- and chloride-dependent GABA transporter 1TM2 and compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  2.90E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  1.68E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  2.65E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  2.79E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  1.68E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  2.59E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  2.77E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  1.68E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  2.66E+3nMAssay Description:H-bonding interaction between amino acid residue (Thr-89) of Sodium- and chloride-dependent GABA transporter 1TM2 and compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  2.65E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Louvain

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  2.90E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Human)
Zentrum F£R Pharmaforschung

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  1.19E+5nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed