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P2'-truncated BACE-1 inhibitors with a novel hydroxethylene-like core.
Eur J Med Chem 45: 542-54 (2010)
Stockholm University
Selective Inhibition of DNA Replicase Assembly by a Non-natural Nucleotide: Exploiting the Structural Diversity of ATP-Binding Sites
ACS Chem Biol 5: 183-94 (2010)
Case Western Reserve University
Synthesis and antiproliferative activity of 7-azaindirubin-3'-oxime, a 7-aza isostere of the natural indirubin pharmacophore.
J Nat Prod 72: 2199-202 (2009)
University Of Athens
Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC).
Bioorg Med Chem 18: 896-908 (2010)
University Of Pennsylvania
Enhancement of EGFR tyrosine kinase inhibition by C-C multiple bonds-containing anilinoquinazolines.
Bioorg Med Chem 18: 870-9 (2010)
Gakushuin University
Design, synthesis and primary activity assay of bi- or tri-peptide analogues with the scaffold l-arginine as amino-peptidase N/CD13 inhibitors.
Bioorg Med Chem 18: 887-95 (2010)
Shandong University
Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition.
Bioorg Med Chem Lett 20: 469-73 (2010)
Pfizer
Evaluation of pyrrolin-2-one derivatives synthesized by a new practical method as inhibitors of plasminogen activator inhibitor-1 (PAI-1).
Bioorg Med Chem Lett 20: 546-8 (2010)
Mitsubishi Tanabe Pharma
Structure-guided design of alpha-amino acid-derived Pin1 inhibitors.
Bioorg Med Chem Lett 20: 586-90 (2010)
Vernalis (R&D)
Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies.
Bioorg Med Chem Lett 20: 636-9 (2010)
Wyeth Research
Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases.
Bioorg Med Chem Lett 20: 537-40 (2010)
University Of Cambridge
Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase.
Bioorg Med Chem Lett 20: 571-5 (2010)
Boehringer Ingelheim Pharmaceuticals
Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes.
Bioorg Med Chem Lett 20: 594-9 (2010)
F. Hoffmann-La Roche
5-Substituted [1]pyrindine derivatives with antiproliferative activity.
Eur J Med Chem 45: 896-901 (2010)
University Of Paris
3D-QSAR, molecular docking studies, and binding mode prediction of thiolactomycin analogs as mtFabH inhibitors.
J Enzyme Inhib Med Chem 25: 240-9 (2010)
China Pharmaceutical University
Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors.
J Med Chem 53: 1146-58 (2010)
Wyeth Research
Lead optimization of N-3-substituted 7-morpholinotriazolopyrimidines as dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors: discovery of PKI-402.
J Med Chem 53: 798-810 (2010)
Wyeth Research
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.
Nat Chem Biol 6: 25-33 (2009)
The Scripps Research Institute
Inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores.
Bioorg Med Chem 18: 182-9 (2010)
National Cancer Institute-Frederick
Discovery of 3,6-dihydro-2H-pyran as a morpholine replacement in 6-aryl-1H-pyrazolo[3,4-d]pyrimidines and 2-arylthieno[3,2-d]pyrimidines: ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR).
Bioorg Med Chem Lett 20: 640-3 (2010)
Wyeth Research
Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423.
Bioorg Med Chem Lett 20: 665-72 (2010)
University Of Michigan Medical School
Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.
Bioorg Med Chem Lett 20: 554-7 (2010)
Northwestern University
Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.
Bioorg Med Chem Lett 20: 628-31 (2010)
Hunter College And The Graduate Center Of The City University Of New York
Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK(1) receptor antagonists.
Bioorg Med Chem Lett 20: 623-7 (2010)
Glaxosmithkline
Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application.
Bioorg Med Chem Lett 20: 603-7 (2010)
Novartis Institutes For Biomedical Research
Triazole oxytocin antagonists: Identification of an aryloxyazetidine replacement for a biaryl substituent.
Bioorg Med Chem Lett 20: 516-20 (2010)
Pfizer
Synthesis, pharmacological studies and molecular modeling of some tetracyclic 1,3-diazepinium chlorides.
Bioorg Med Chem 18: 909-21 (2010)
University Of The West Indies
The comparative antimalarial properties of weak base and neutral synthetic ozonides.
Bioorg Med Chem Lett 20: 563-6 (2010)
University Of Nebraska Medical Center
Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRbeta and low blood-brain penetration.
Bioorg Med Chem Lett 20: 689-93 (2010)
Wyeth Pharmaceuticals
3D QSAR studies on ketoamides of human cathepsin K inhibitors based on two different alignment methods.
Eur J Med Chem 45: 667-81 (2010)
Chinese Academy Of Sciences
Synthesis and biological evaluation of [1,2,4]triazino[4,3-a] benzimidazole acetic acid derivatives as selective aldose reductase inhibitors.
Eur J Med Chem 45: 909-14 (2010)
Institute Of Pharmaceutical Sciences
Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors.
Bioorg Med Chem 18: 292-304 (2010)
The University Of Arizona
Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology.
Bioorg Med Chem Lett 20: 121-4 (2010)
Kitasato University
HIV-1 protease inhibitors with a transition-state mimic comprising a tertiary alcohol: improved antiviral activity in cells.
J Med Chem 53: 607-15 (2010)
Uppsala University
Synthesis of 3-[(N-carboalkoxy)ethylamino]-indazole-dione derivatives and their biological activities on human liver carbonyl reductase.
Bioorg Med Chem 18: 134-41 (2010)
Howard University
Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers.
Bioorg Med Chem Lett 20: 56-9 (2010)
Huazhong Agricultural University
SAR of N-phenyl piperidine based oral integrin alpha5beta1 antagonists.
Bioorg Med Chem Lett 20: 65-8 (2010)
Jerini
Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.
Bioorg Med Chem Lett 20: 632-5 (2010)
Wyeth Research
Optimization of orally bioavailable alkyl amine renin inhibitors.
Bioorg Med Chem Lett 20: 694-9 (2010)
Vitae Pharmaceuticals
Enhancing the intestinal absorption of molecules containing the polar guanidino functionality: a double-targeted prodrug approach.
J Med Chem 53: 624-32 (2010)
University Of Michigan
Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation.
J Med Chem 53: 723-33 (2010)
Sapienza University Of Rome
Structure-activity relationship studies leading to the identification of (2E)-3-[l-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a potent and selective prostanoid EP3 receptor antagonist, as a novel antiplatelet agent that
J Med Chem 53: 18-36 (2010)
Decode Chemistry
Identification of a novel ligand binding motif in the transthyretin channel.
Bioorg Med Chem 18: 100-10 (2010)
Universidade Federal Do Rio De Janeiro
Exploring SAR features in diverse library of 4-cyanomethyl-pyrazole-3-carboxamides suitable for further elaborations as CB1 antagonists.
Bioorg Med Chem Lett 20: 26-30 (2010)
7Tm Pharma
Pyrazole derived from (+)-3-carene; a novel potent, selective scaffold for sphingosine-1-phosphate (S1P(1)) receptor agonists.
Bioorg Med Chem Lett 20: 35-7 (2010)
Novartis Institutes For Biomedical Research
Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor.
Bioorg Med Chem Lett 20: 104-7 (2010)
Abbott Laboratories
Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor.
Bioorg Med Chem Lett 20: 92-6 (2010)
Pfizer
Oxo-bridged isomers of aza-trishomocubane sigma (sigma) receptor ligands: Synthesis, in vitro binding, and molecular modeling.
Bioorg Med Chem Lett 20: 145-8 (2010)
University Of Sydney
Coumarins as novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer.
Bioorg Med Chem Lett 20: 272-5 (2010)
Sumitomo Chemical
Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors.
Bioorg Med Chem Lett 20: 653-6 (2010)
Wyeth Research
Radiosynthesis and radiopharmacological evaluation of cyclin-dependent kinase 4 (Cdk4) inhibitors.
Eur J Med Chem 45: 727-37 (2010)
Institute Of Radiopharmacy
Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands.
Eur J Med Chem 45: 752-9 (2010)
Universit£
Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones.
Eur J Med Chem 45: 526-35 (2010)
Universidade Federal Do Rio Grande Do Sul
Heme oxygenase inhibition by 2-oxy-substituted 1-azolyl-4-phenylbutanes: effect of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone.
Chem Biol Drug Des 75: 68-90 (2010)
Queen'S University
Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites.
J Med Chem 52: 7706-23 (2009)
Astrazeneca
A strategy to minimize reactive metabolite formation: discovery of (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a potent, orally bioavailable corticotropin-releasing factor-1 receptor antagonist.
J Med Chem 52: 7653-68 (2009)
Bristol-Myers Squibb
Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket.
J Med Chem 52: 7604-17 (2009)
Kyoto Pharmaceutical University
Design, synthesis, and 3D-QSAR analysis of novel 1,3,4-oxadiazol-2(3H)-ones as protoporphyrinogen oxidase inhibitors.
J Agric Food Chem 58: 2643-51 (2010)
Central China Normal University
Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The side chain benzylic methylene.
Bioorg Med Chem Lett 20: 97-9 (2010)
Universit£
3D QSAR studies on 3,4-dihydroquinazolines as T-type calcium channel blocker by comparative molecular similarity indices analysis (CoMSIA).
Bioorg Med Chem Lett 20: 38-41 (2010)
Kyung Hee University
Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders.
J Med Chem 53: 2345-53 (2010)
Roche Palo Alto
Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis.
J Med Chem 53: 573-85 (2010)
Decode Chemistry
Blockade of X4-tropic HIV-1 cellular entry by GSK812397, a potent noncompetitive CXCR4 receptor antagonist.
Antimicrob Agents Chemother 54: 817-24 (2010)
Glaxosmithkline
Synthesis and anticancer activities of ageladine A and structural analogs.
Bioorg Med Chem Lett 20: 83-6 (2010)
Beckman Research Institute At City Of Hope
Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors.
J Med Chem 53: 419-31 (2010)
Translational Research Institute
Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles.
Bioorg Med Chem Lett 20: 78-82 (2010)
Chemical Diversity Research Institute
The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.
Bioorg Med Chem Lett 20: 157-60 (2010)
Novartis Institutes For Biomedical Research
Towards development of selective and reversible pyrazoline based MAO-inhibitors: Synthesis, biological evaluation and docking studies.
Bioorg Med Chem Lett 20: 132-6 (2010)
Institute Of Technology
Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor.
Bioorg Med Chem Lett 20: 276-9 (2010)
Renovis
A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors.
Bioorg Med Chem Lett 20: 153-6 (2010)
Vertex Pharmaceuticals
Discovery of benzimidazole-diamide finger loop (Thumb Pocket I) allosteric inhibitors of HCV NS5B polymerase: Implementing parallel synthesis for rapid linker optimization.
Bioorg Med Chem Lett 20: 196-200 (2010)
Boehringer Ingelheim (Canada)
Pyrrole derivatives as potent inhibitors of lymphocyte-specific kinase: Structure, synthesis, and SAR.
Bioorg Med Chem Lett 20: 108-11 (2010)
Taisho Pharmaceutical
Ring-fused pyrazole derivatives as potent inhibitors of lymphocyte-specific kinase (Lck): Structure, synthesis, and SAR.
Bioorg Med Chem Lett 20: 112-6 (2010)
Taisho Pharmaceutical
Theoretical and structural analysis of the active site of the transcriptional regulators LasR and TraR, using molecular docking methodology for identifying potential analogues of acyl homoserine lactones (AHLs) with anti-quorum sensing activity.
Eur J Med Chem 45: 608-15 (2010)
Universidad De Cartagena-Facultad De Ciencias Exactas Y
Novel tumor-targeted RGD peptide-camptothecin conjugates: synthesis and biological evaluation.
Bioorg Med Chem 18: 64-72 (2010)
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni
A single step purification for autolytic zinc proteinases.
Bioorg Med Chem Lett 20: 280-2 (2010)
Duke University
Biotransformation of isoimperatorin and imperatorin by Glomerella cingulata and beta-secretase inhibitory activity.
Bioorg Med Chem 18: 455-9 (2010)
Kinki University
Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase.
Eur J Med Chem 45: 447-54 (2010)
The University Of Queensland
8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists.
Eur J Med Chem 45: 782-9 (2010)
Chemical Diversity Research Institute
The binding of synthetic retinoids to lipocalin beta-lactoglobulins.
J Med Chem 53: 514-8 (2010)
University Of Helsinki
TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1.
Antimicrob Agents Chemother 54: 718-27 (2010)
Tibotec-Virco
SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro.
Antimicrob Agents Chemother 54: 660-72 (2010)
Scynexis
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II.
Bioorg Med Chem 18: 190-201 (2010)
Wyeth Research
Isoxazole analogues bind the system xc- transporter: structure-activity relationship and pharmacophore model.
Bioorg Med Chem 18: 202-13 (2010)
The University Of Montana
Synthesis and structure-activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT(1A) receptor and the serotonin transporter.
Bioorg Med Chem Lett 20: 222-7 (2010)
Wyeth Research
Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton.
Bioorg Med Chem Lett 20: 418-21 (2010)
Fudan University
Addressing species specific metabolism and solubility issues in a quinoline series of oral PDE4 inhibitors.
Bioorg Med Chem Lett 20: 137-40 (2010)
Glaxosmithkline
Novel lead for potent inhibitors of breast cancer resistance protein (BCRP).
Bioorg Med Chem Lett 20: 180-3 (2010)
University Of Bonn
4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists.
Bioorg Med Chem Lett 20: 209-12 (2010)
Wyeth Pharmaceuticals
Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor.
Bioorg Med Chem Lett 20: 175-9 (2010)
Janssen-Cilag
Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors.
Eur J Med Chem 45: 639-46 (2010)
Sun Yat-Sen University
Silicon switch approach in TRPV1 antagonist MK-056 and its analogues.
Bioorg Med Chem 18: 111-6 (2010)
Sookmyung Women'S University
Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase.
Bioorg Med Chem 18: 267-73 (2010)
Utrecht University
Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity.
Bioorg Med Chem Lett 20: 184-8 (2010)
Novartis Institutes For Biomedical Research
Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction.
J Med Chem 52: 7970-3 (2009)
University Of Michigan
Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors.
J Med Chem 53: 402-18 (2010)
Harvard Medical School
Design of O-acetylserine sulfhydrylase inhibitors by mimicking nature.
J Med Chem 53: 345-56 (2010)
University Of Parma
Displacement assay for the detection of stabilizers of inactive kinase conformations.
J Med Chem 53: 357-67 (2010)
Chemical Genomics Centre Of The Max Planck Society
Subnanomolar inhibitor of cytochrome bc1 complex designed by optimizing interaction with conformationally flexible residues.
J Am Chem Soc 132: 185-94 (2010)
Central China Normal University
Synthesis, affinity profile and functional activity of potent chiral muscarinic antagonists with a pyrrolidinylfuran structure.
J Med Chem 53: 201-7 (2010)
Universita Di Firenze
Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists.
J Med Chem 53: 77-105 (2010)
The Genomics Institute Of The Novartis Research Foundation
Synthesis and in vitro evaluation of fluorinated diphenyloxide derivatives and sulfur analogs as serotonin transporter ligands.
Bioorg Med Chem 18: 236-41 (2010)
University Of Tours
2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization.
Bioorg Med Chem Lett 20: 334-7 (2010)
Abbott Laboratories
Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1H)-pyrazole derivatives.
Eur J Med Chem 45: 800-4 (2010)
Universit£
Design and synthesis of novel P2 substituents in diol-based HIV protease inhibitors.
Eur J Med Chem 45: 160-70 (2010)
Stockholm University
Improving the developability profile of pyrrolidine progesterone receptor partial agonists.
Bioorg Med Chem Lett 20: 371-4 (2010)
Glaxosmithkline
Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats.
Bioorg Med Chem Lett 20: 341-5 (2010)
Daiichi Sankyo
X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.
J Med Chem 53: 230-40 (2010)
The Scripps Research Institute
Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity.
J Med Chem 53: 295-315 (2010)
Abbott Laboratories
2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode.
Bioorg Med Chem Lett 20: 330-3 (2010)
Abbott Laboratories
Novel sulfamoyl benzamides as selective CB(2) agonists with improved in vitro metabolic stability.
Bioorg Med Chem Lett 20: 387-91 (2010)
Adolor
Chloro-substituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity.
J Med Chem 53: 147-54 (2010)
Universite De Liege
Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy.
J Med Chem 52: 7946-9 (2009)
Pfizer
Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases.
J Med Chem 53: 221-9 (2010)
University Of Dundee
5-OHKF and NorKA, depsipeptides from a Hawaiian collection of Bryopsis pennata: binding properties for NorKA to the human neuropeptide Y Y1 receptor.
J Nat Prod 72: 2172-6 (2009)
The University Of Mississippi
Morpholine derivatives greatly enhance the selectivity of mammalian target of rapamycin (mTOR) inhibitors.
J Med Chem 52: 7942-5 (2009)
Wyeth Research
Synthesis and structure-activity relationships of N-benzyl-N-(X-2-hydroxybenzyl)-N'-phenylureas and thioureas as antitumor agents.
Bioorg Med Chem 18: 305-13 (2010)
Nanjing University
Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.
Bioorg Med Chem 18: 433-54 (2010)
Vienna University Of Technology
Design, synthesis and biological evaluation of thiazolidinone derivatives as potential EGFR and HER-2 kinase inhibitors.
Bioorg Med Chem 18: 314-9 (2010)
Nanjing University
Synthesis of a hydrolytically stable, fluorescent-labeled ATP analog as a tool for probing adenylyl cyclases.
Bioorg Med Chem Lett 20: 232-5 (2010)
Ernst-Moritz-Arndt-University
p16(INK4a) Peptide mimetics identified via virtual screening.
Bioorg Med Chem Lett 20: 403-5 (2010)
Veterans Affairs Medical Center
Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase.
Bioorg Med Chem Lett 20: 206-8 (2010)
The Scripps Research Institute
5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor.
Bioorg Med Chem Lett 20: 213-7 (2010)
Amira Pharmaceuticals
Aminopyridinecarboxamide-based inhibitors: Structure-activity relationship.
Bioorg Med Chem 18: 403-14 (2010)
Pfizer
Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group.
Bioorg Med Chem 18: 415-25 (2010)
Georgia Institute Of Technology
Pyrazolone based TGFbetaR1 kinase inhibitors.
Bioorg Med Chem Lett 20: 326-9 (2010)
Biogen Idec
Application of ring-closing metathesis macrocyclization to the development of Tsg101-binding antagonists.
Bioorg Med Chem Lett 20: 318-21 (2010)
National Cancer Institute-Frederick
2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety.
Bioorg Med Chem Lett 20: 346-9 (2010)
Merck Research Laboratories
Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines.
Bioorg Med Chem Lett 20: 228-31 (2010)
Institute Infectious Diseases Initiative
Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity.
Bioorg Med Chem Lett 20: 266-71 (2010)
Pfizer
Antimalarial activity of azadipeptide nitriles.
Bioorg Med Chem Lett 20: 252-5 (2010)
University Of Queensland
Dipeptide-derived nitriles containing additional electrophilic sites: potentially irreversible inhibitors of cysteine proteases.
J Enzyme Inhib Med Chem 24: 1245-52 (2009)
Rheinische Friedrich-Wilhelms-Universitat Bonn
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
J Med Chem 53: 335-44 (2010)
Universita Degli Studi Di Firenze
Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes.
J Med Chem 53: 178-90 (2010)
Universite Louis Pasteur
Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues.
J Med Chem 53: 191-200 (2010)
Universidad De Santiago De Compostela
Discovery of orally available integrin alpha5beta1 antagonists.
Bioorg Med Chem Lett 20: 380-2 (2010)
Jerini
Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
J Med Chem 53: 52-60 (2010)
National Human Genome Research Institute
Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.
J Med Chem 53: 37-51 (2010)
National Human Genome Research Institute
Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (hsp90) molecular chaperone.
J Med Chem 53: 499-503 (2010)
Pfizer
Discovery of potent, selective, and orally bioavailable PDE5 inhibitor: Methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-ylmethylcarbamate (CKD 533).
Bioorg Med Chem Lett 20: 383-6 (2010)
Chong Kun Dang Research Institute
Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.
Bioorg Med Chem Lett 20: 294-8 (2010)
Ortho-Biotech Oncology Research & Development
Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH).
Eur J Med Chem 45: 335-42 (2010)
Technische Universit£T Braunschweig
Synthesis of aryl phosphates based on pyrimidine and triazine scaffolds.
Eur J Med Chem 45: 244-55 (2010)
Cnrs Umr 176
4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.
J Med Chem 53: 241-53 (2010)
University Of Lisbon
Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.
J Med Chem 53: 471-80 (2010)
National Institute Of Diabetes And Digestive And Kidney Diseases
Solid phase synthesis of novel pyrrolidinedione analogs as potent HIV-1 integrase inhibitors.
J Comb Chem 12: 84-90 (2010)
Bristol-Myers Squibb
Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists.
J Med Chem 52: 7962-5 (2009)
Glaxosmithkline
Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France.
Antimicrob Agents Chemother 54: 328-32 (2009)
Bicetre Hospital
A novel class of meso-tetrakis-porphyrin derivatives exhibits potent activities against hepatitis C virus genotype 1b replicons in vitro.
Antimicrob Agents Chemother 54: 197-206 (2010)
Yale University
Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties.
Bioorg Med Chem 17: 8221-33 (2009)
Daiichi Sankyo
Optimization of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin V2 receptor agonists and discussion of their binding modes.
Bioorg Med Chem 17: 8161-7 (2009)
Astellas Pharma
Thyroid receptor agonists for the treatment of androgenetic alopecia.
Bioorg Med Chem Lett 20: 306-8 (2010)
Pfizer
Structural studies of pterin-based inhibitors of dihydropteroate synthase.
J Med Chem 53: 166-77 (2010)
University Of Tennessee Health Science Center
Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors.
J Med Chem 53: 208-20 (2010)
Cea
Interaction studies between human alpha-tocopherol transfer protein and nitric oxide donor tocopherol analogues with LDL-protective activity.
Bioorg Med Chem 17: 8143-8 (2009)
Universidad De La Rep£Blica
Synthesis and structural optimization of multiple H-bonding region of diarylalkyl (thio)amides as novel TRPV1 antagonists.
Bioorg Med Chem 17: 8149-60 (2009)
Seoul National University
Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies.
Bioorg Med Chem Lett 20: 392-7 (2010)
Institutions
Synthesis and in vivo evaluation of 3-substituted gababutins.
Bioorg Med Chem Lett 20: 362-5 (2010)
Pfizer
Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K.
Bioorg Med Chem Lett 20: 375-9 (2010)
Wyeth Research
Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577.
Bioorg Med Chem Lett 19: 6882-9 (2009)
Bristol-Myers Squibb
Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes.
Bioorg Med Chem Lett 19: 6865-8 (2009)
University Of New Orleans
Incorporation of water-solubilizing groups in pyrazolopyrimidine mTOR inhibitors: discovery of highly potent and selective analogs with improved human microsomal stability.
Bioorg Med Chem Lett 19: 6830-5 (2009)
Wyeth Research
Tetrahydroquinoline derivatives as CRTH2 antagonists.
Bioorg Med Chem Lett 19: 6840-4 (2009)
Amgen
N3-arylmalonamides: a new series of thieno[3,2-b]pyridine based inhibitors of c-Met and VEGFR2 tyrosine kinases.
Bioorg Med Chem Lett 19: 6836-9 (2009)
Methylgene
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation.
Bioorg Med Chem 17: 8174-85 (2009)
Universit£
Exploration of O-spiroketal C-arylglucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
Bioorg Med Chem Lett 19: 6877-81 (2009)
Chinese Academy Of Sciences
Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication.
Bioorg Med Chem Lett 19: 6893-7 (2009)
Niddk
Synthesis and pharmacological evaluation of analogs of indole-based cannabimimetic agents.
Chem Biol Drug Des 75: 106-14 (2010)
UniversitÀ
Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template.
Chem Biol Drug Des 75: 18-28 (2010)
Ariad Pharmaceuticals
Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent.
J Med Chem 52: 8010-24 (2009)
Wyeth Research
Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors.
J Med Chem 52: 8025-37 (2009)
Max Planck Institute Of Molecular Physiology
Three dimensional pharmacophore modelling for c-Kit receptor tyrosine kinase inhibitors.
Eur J Med Chem 45: 393-404 (2010)
Punjabi University
Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
J Med Chem 52: 7950-3 (2009)
University Of North Carolina
1,2,4-Triazolyl azabicyclo[3.1.0]hexanes: a new series of potent and selective dopamine D(3) receptor antagonists.
J Med Chem 53: 374-91 (2010)
Glaxosmithkline
Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist.
J Med Chem 52: 7974-92 (2009)
Daiichi Sankyo
Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of cyclin D1-CDK4: synthesis, biological evaluation and structure-activity relationships. Part 2.
Bioorg Med Chem 17: 7850-60 (2009)
Daiichi Sankyo
Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors.
Bioorg Med Chem Lett 19: 6872-6 (2009)
Memorial Sloan-Kettering Cancer Center
Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.
Bioorg Med Chem Lett 19: 6851-4 (2009)
University Of California
Terpenoids. III: Synthesis and biological evaluation of 23-hydroxybetulinic acid derivatives as novel inhibitors of glycogen phosphorylase.
Bioorg Med Chem Lett 19: 6966-9 (2009)
China Pharmaceutical University
Discovery of a novel Her-1/Her-2 dual tyrosine kinase inhibitor for the treatment of Her-1 selective inhibitor-resistant non-small cell lung cancer.
J Med Chem 52: 6880-8 (2009)
Hanmi Research Center
Synthesis and evaluation of a new generation of orally efficacious benzimidazole-based poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors as anticancer agents.
J Med Chem 52: 6803-13 (2009)
Abbott Laboratories
Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy.
J Med Chem 52: 6782-9 (2009)
Istituto Di Ricerche Di Biologia Molecolare
Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.
J Med Chem 52: 6716-23 (2009)
Institute For Medical Research
Constrained peptidomimetics reveal detailed geometric requirements of covalent prolyl oligopeptidase inhibitors.
J Med Chem 52: 6672-84 (2009)
Mcgill University
Selective Kv1.5 blockers: development of (R)-1-(methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a potential treatment for atrial arrhythmia.
J Med Chem 52: 6531-4 (2009)
Wyeth Research
Binding ensemble profiling with photoaffinity labeling (BEProFL) approach: mapping the binding poses of HDAC8 inhibitors.
J Med Chem 52: 7003-13 (2009)
University Of Illinois At Chicago
Might adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine?
J Med Chem 52: 7319-22 (2009)
Universita Degli Studi Di Camerino
BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa.
Antimicrob Agents Chemother 54: 533-5 (2010)
H�Pital De Bic�Tre
Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola.
Antimicrob Agents Chemother 54: 45-51 (2010)
Institut Pasteur
Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: exploration of 5-6 fused rings as alternative S1 moieties.
Bioorg Med Chem 17: 8206-20 (2009)
Daiichi Sankyo
5-Vinyl-3-pyridinecarbonitrile inhibitors of PKCtheta: optimization of enzymatic and functional activity.
Bioorg Med Chem 17: 7933-48 (2009)
Wyeth Research
Synthesis, antibacterial activities and molecular docking studies of peptide and Schiff bases as targeted antibiotics.
Bioorg Med Chem 17: 7861-71 (2009)
Nanjing University
Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.
Bioorg Med Chem 17: 7924-32 (2009)
Eberhard Karls University Tuebingen
Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors.
Bioorg Med Chem Lett 19: 6890-2 (2009)
Wyeth Research
Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Bioorg Med Chem Lett 19: 6855-61 (2009)
University Of Alberta
1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT(6) receptor ligands.
Bioorg Med Chem Lett 19: 6935-8 (2009)
Wyeth Research
3-arylidene-5-(4-isobutylphenyl)-2(3H)-furanones: a new series of anti-inflammatory and analgesic compounds having antimicrobial activity.
J Enzyme Inhib Med Chem 25: 323-30 (2010)
Jamia Hamdard
Biaryl ethers as novel non-nucleoside reverse transcriptase inhibitors with improved potency against key mutant viruses.
J Med Chem 52: 7163-9 (2009)
Merck Research Laboratory
Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors.
J Med Chem 52: 7310-4 (2009)
Universite Catholique De Louvain
4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.
J Med Chem 52: 7122-31 (2009)
National Cancer Institute-Bethesda
Discovery of novel benzoxazinones as potent and orally active long chain fatty acid elongase 6 inhibitors.
J Med Chem 52: 7289-300 (2009)
Tsukuba Research Institute
N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53.
Bioorg Med Chem 17: 7884-93 (2009)
Nih
COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans.
Bioorg Med Chem Lett 19: 6922-5 (2009)
Universidad Nacional De Colombia
Spare interactions of highly potent [Arg(14),Lys(15)]nociceptin for cooperative induction of ORL1 receptor activation.
Bioorg Med Chem 17: 7904-8 (2009)
Kyushu University
Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones.
Bioorg Med Chem 17: 7915-23 (2009)
Institute Of Pharmaceutical Industry
N-Bridged bicyclic sulfonamides as inhibitors of gamma-secretase.
Bioorg Med Chem Lett 19: 6952-6 (2009)
Elan Pharmaceuticals
NSAID-derived gamma-secretase modulators. Part III: Membrane anchoring.
Bioorg Med Chem Lett 19: 6986-90 (2009)
Technische Universit£T Darmstadt
Identification of novel agonists of the integrin CD11b/CD18.
Bioorg Med Chem Lett 19: 6902-6 (2009)
Department Of Medicine And University Of Miami
Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors.
Eur J Med Chem 45: 805-10 (2010)
TBA
Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase.
Eur J Med Chem 45: 186-92 (2010)
Institute For Medical Research And Occupational Health
Identification of (beta-carboxyethyl)-rhodanine derivatives exhibiting peroxisome proliferator-activated receptor gamma activity.
Eur J Med Chem 45: 193-202 (2010)
Sookmyung Women'S University
Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists.
Bioorg Med Chem 17: 8003-11 (2009)
Ewha Womans University
Imidazo[1,2-a]pyrazine diaryl ureas: inhibitors of the receptor tyrosine kinase EphB4.
Bioorg Med Chem Lett 19: 6991-5 (2009)
Cgi Pharmaceuticals
Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives.
Eur J Med Chem 45: 379-86 (2010)
Universidad Nacional Aut£Noma De M£Xico
Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1).
J Med Chem 52: 7142-56 (2009)
University Of Manchester
beta-Lactams derived from a carbapenem chiron are selective inhibitors of human fatty acid amide hydrolase versus human monoacylglycerol lipase.
J Med Chem 52: 7054-68 (2009)
Universite Catholique De Louvain
Identification of death-associated protein kinases inhibitors using structure-based virtual screening.
J Med Chem 52: 7323-7 (2009)
Pharmadesign
Synthesis and evaluation of three 18F-labeled aminophenylbenzothiazoles as amyloid imaging agents.
J Med Chem 52: 7090-102 (2009)
Katholieke Universiteit Leuven
Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors.
J Med Chem 52: 5217-27 (2009)
Irbm, Mrl Rome
The spirocyclopropyl moiety as a methyl surrogate in the structure of l-fucosidase and l-rhamnosidase inhibitors.
Bioorg Med Chem 17: 8020-6 (2009)
Universit£
Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS.
Bioorg Med Chem Lett 19: 6502-6 (2009)
Vanderbilt University Medical Center
Use of 5-hydroxy-4H-benzo[1,4]oxazin-3-ones as beta2-adrenoceptor agonists.
Bioorg Med Chem Lett 19: 6640-4 (2009)
Boehringer Ingelheim Pharma
Novel pyrazolopyrimidines as highly potent B-Raf inhibitors.
Bioorg Med Chem Lett 19: 6957-61 (2009)
Wyeth Research
Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands.
Bioorg Med Chem Lett 19: 6806-9 (2009)
Sapienza University Of Rome
Sigma-1 ligands: Tic-hydantoin as a key pharmacophore.
Eur J Med Chem 45: 256-63 (2010)
University Of Lille
Discovery of potent and reversible monoacylglycerol lipase inhibitors.
Chem Biol 16: 1045-52 (2009)
University Of California Irvine
New insights into homopiperazine-based 5-HT1A/5-HT7R ligands: synthesis and biological evaluation.
J Enzyme Inhib Med Chem 25: 301-5 (2010)
University Of Orleans
Synthesis and biological activity of progesterone derivatives as 5alpha-reductase inhibitors, and their effect on hamster prostate weight.
J Enzyme Inhib Med Chem 25: 306-11 (2010)
Universidad Nacional Autonoma De Mexico
Inhibitory effects of thioethers on fatty acid synthase and 3T3-L1 cells.
J Enzyme Inhib Med Chem 25: 290-5 (2010)
Graduate University Of Chinese Academy Of Sciences
Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms.
J Enzyme Inhib Med Chem 25: 331-9 (2010)
Institute Of Chemical Technology
Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.
J Med Chem 52: 7170-85 (2009)
Irbm/Merck Research Laboratories
Azaindole hydroxamic acids are potent HIV-1 integrase inhibitors.
J Med Chem 52: 7211-9 (2009)
Pfizer
Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors.
Bioorg Med Chem Lett 19: 6519-23 (2009)
Wyeth Research
Discovery and SAR of cyclic isothioureas as novel NPY Y1 receptor antagonists.
Bioorg Med Chem Lett 19: 6801-5 (2009)
Schering-Plough Research Institute
2-Amino-5-aryl-pyridines as selective CB2 agonists: synthesis and investigation of structure-activity relationships.
Bioorg Med Chem Lett 19: 6578-81 (2009)
Glaxosmithkline
5-Aryl indanones and derivatives as non-steroidal progesterone receptor modulators.
Bioorg Med Chem Lett 19: 6666-9 (2009)
Wyeth Research
Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors.
Bioorg Med Chem Lett 19: 6591-4 (2009)
Amgen
The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144.
J Nat Prod 72: 1944-8 (2009)
Wyeth Research
Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement.
J Med Chem 52: 7069-80 (2009)
Probiodrug
Synthesis and biological evaluation of the metabolites of 2-(1-{3-[(6-chloronaphthalen-2-yl)sulfonyl]propanoyl}piperidin-4-yl)-5-methyl-1,2-dihydro-3H-imidazo[1,5-c]imidazol-3-one.
Bioorg Med Chem 17: 7993-8002 (2009)
Takeda Pharmaceutical
alphavbeta3 Integrin-targeting Arg-Gly-Asp (RGD) peptidomimetics containing oligoethylene glycol (OEG) spacers.
J Med Chem 52: 7029-43 (2009)
Universite Catholique De Louvain
chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain.
J Med Chem 52: 6991-7002 (2009)
Xenome
Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines.
Bioorg Med Chem 17: 7987-92 (2009)
National Institute Of Diabetes And Digestive And Kidney Diseases
2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2.
Bioorg Med Chem Lett 19: 6529-33 (2009)
Vertex Pharmaceuticals
Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.
Bioorg Med Chem Lett 19: 6524-8 (2009)
Astrazeneca R&D Boston
Structural basis for the inhibitor recognition of human Lyn kinase domain.
Bioorg Med Chem Lett 19: 6557-60 (2009)
Osaka Prefecture University
(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate.
J Med Chem 52: 6962-5 (2009)
Wyeth Research
Lorneic acids, trialkyl-substituted aromatic acids from a marine-derived actinomycete.
J Nat Prod 72: 2046-8 (2009)
Nippon Suisan Kaisha
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.
J Med Chem 52: 7249-57 (2009)
Instituto De Quimica Medica (Csic)
Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators.
J Med Chem 52: 7186-91 (2009)
Acadia Pharmaceuticals
Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction.
J Med Chem 52: 7044-53 (2009)
Amgen
Heterobiaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part II.
Bioorg Med Chem Lett 19: 6613-7 (2009)
Amri
Discovery of highly potent and selective type I B-Raf kinase inhibitors.
Bioorg Med Chem Lett 19: 6571-4 (2009)
Wyeth Research
Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase.
Bioorg Med Chem Lett 19: 6548-51 (2009)
Johnson & Johnson Pharmaceutical Research And Development
Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo.
Bioorg Med Chem Lett 19: 6670-4 (2009)
Astrazeneca
Synthesis and PKCtheta inhibitory activity of a series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles.
Bioorg Med Chem Lett 19: 6575-7 (2009)
Wyeth Research
Design and synthesis of novel histone deacetylase inhibitor derived from nuclear localization signal peptide.
Bioorg Med Chem Lett 19: 6588-90 (2009)
Georgia Institute Of Technology
Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma.
Bioorg Med Chem Lett 19: 6565-70 (2009)
Nicox Research Institute
Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists.
Bioorg Med Chem Lett 19: 6604-7 (2009)
Pfizer
Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II.
Bioorg Med Chem Lett 19: 6691-5 (2009)
Genomics Institute Of The Novartis Research Foundation
N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett 19: 6552-6 (2009)
Methylgene
Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.
Bioorg Med Chem Lett 19: 6623-6 (2009)
Vanderbilt University Medical Center
Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening.
Bioorg Med Chem Lett 19: 6770-4 (2009)
University Of Leeds
4-(3-aryloxyaryl)quinoline alcohols are liver X receptor agonists.
Bioorg Med Chem 17: 8086-92 (2009)
Wyeth Research
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
Bioorg Med Chem Lett 19: 6645-8 (2009)
Taisho Pharmaceutical
New classes of potent and bioavailable human renin inhibitors.
Bioorg Med Chem Lett 19: 6762-5 (2009)
Actelion Pharmaceuticals
Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors.
Bioorg Med Chem Lett 19: 6600-3 (2009)
Leiden University
Novel biphenylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) delta selective antagonists.
Bioorg Med Chem Lett 19: 6595-9 (2009)
The University Of Tokyo
Synthesis, spectral characterization and biological evaluation of phosphorylated derivatives of galanthamine.
Eur J Med Chem 45: 203-9 (2010)
Sri Venkateswara University
Identification of lead compounds as antagonists of protein Bcl-xL with a diversity-oriented multidisciplinary approach.
J Med Chem 52: 7856-67 (2009)
Universita Degli Studi Di Salerno
Peptide inhibitors of HIV-1 integrase: from mechanistic studies to improved lead compounds.
Bioorg Med Chem 17: 7635-42 (2009)
The Hebrew University Of Jerusalem
Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.
Bioorg Med Chem Lett 19: 6793-6 (2009)
Renovis
Pentacycle derivatives as cannabinoid CB1 receptor ligands.
Bioorg Med Chem Lett 19: 6632-6 (2009)
Green Cross
Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.
J Nat Prod 72: 1857-63 (2009)
University Of California Santa Cruz
Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases).
J Med Chem 52: 7192-210 (2009)
Georgia Institute Of Technology
Discovery of potent and selective inhibitors of the mammalian target of rapamycin (mTOR) kinase.
J Med Chem 52: 7081-9 (2009)
Wyeth Research
Biaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part I.
Bioorg Med Chem Lett 19: 6608-12 (2009)
Amri
Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.
Bioorg Med Chem Lett 19: 6618-22 (2009)
East China Normal University
Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.
Bioorg Med Chem Lett 19: 6649-54 (2009)
Universit£
Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates.
Bioorg Med Chem Lett 19: 6682-5 (2009)
Jagiellonian University Medical College
Evaluation of basic, heterocyclic ring systems as templates for use as potassium competitive acid blockers (pCABs).
Bioorg Med Chem Lett 19: 6813-7 (2009)
Glaxosmithkline
Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis.
Bioorg Med Chem Lett 19: 6759-61 (2009)
Korea Research Institute Of Bioscience And Biotechnology
Application of desirability-based multi(bi)-objective optimization in the design of selective arylpiperazine derivates for the 5-HT1A serotonin receptor.
Eur J Med Chem 44: 5045-54 (2009)
University Of Porto
18F stilbenes and styrylpyridines for PET imaging of A beta plaques in Alzheimer's disease: a miniperspective.
J Med Chem 53: 933-41 (2010)
University Of Pennsylvania
Lipophilic 2,5-disubstituted pyrroles from the marine sponge Mycale sp. inhibit mitochondrial respiration and HIF-1 activation.
J Nat Prod 72: 1927-36 (2009)
University Of Mississippi
The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay.
Chem Biol Drug Des 74: 547-59 (2009)
Pfizer
Inactivation of acetylcholinesterase by various fluorophores.
J Enzyme Inhib Med Chem 25: 116-20 (2010)
The University Of Montana
14beta-Arylpropiolylamino-17-cyclopropylmethyl-7,8-dihydronormorphinones and related opioids. Further examples of pseudoirreversible mu opioid receptor antagonists.
J Med Chem 52: 6926-30 (2009)
University Of Bristol
Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases.
J Med Chem 52: 6621-36 (2009)
Abbott Laboratories
Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).
J Med Chem 52: 7817-28 (2009)
Universita Degli Studi Di Bari
MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease.
Antimicrob Agents Chemother 54: 305-11 (2009)
Merck Research Laboratories
Hepatitis C virus NS3 protease is activated by low concentrations of protease inhibitors.
Biochemistry 48: 11592-602 (2009)
Uppsala University
Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen).
J Nat Prod 72: 2028-31 (2009)
The Ohio State University
Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies.
J Med Chem 52: 6543-5 (2009)
Oregon State University
Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor.
J Med Chem 52: 7897-900 (2009)
University Of Camerino
Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.
Bioorg Med Chem Lett 19: 6686-90 (2009)
Translational Research Institute And Department Of Molecular Therapeutics
Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).
Bioorg Med Chem Lett 19: 6700-5 (2009)
National Human Genome Research Institute
1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1).
Bioorg Med Chem Lett 19: 6725-32 (2009)
Methylgene
Design, synthesis and biological evaluation of a bivalent micro opiate and adenosine A1 receptor antagonist.
Bioorg Med Chem Lett 19: 6736-9 (2009)
Aix-Marseille Universit£
Structure-based design, synthesis and in vitro characterization of potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and D-homo-estrone.
Bioorg Med Chem Lett 19: 6740-4 (2009)
Institute Of Experimental Genetics
Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach.
Eur J Med Chem 45: 90-7 (2010)
German University In Cairo
3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3.
Bioorg Med Chem 17: 7755-68 (2009)
Wyeth Research
Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles.
Bioorg Med Chem 17: 7802-15 (2009)
Wyeth Research
Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors.
Bioorg Med Chem Lett 19: 6750-4 (2009)
Nanjing University
2-Benzimidazolyl-9-(chroman-4-yl)-purinone derivatives as JAK3 inhibitors.
Bioorg Med Chem Lett 19: 6788-92 (2009)
Ligand Pharmaceuticals
Heterocyclic 1,7-disubstituted indole sulfonamides are potent and selective human EP3 receptor antagonists.
Bioorg Med Chem Lett 19: 6797-800 (2009)
Decode Chemistry
Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors.
Bioorg Med Chem Lett 19: 6784-7 (2009)
Lexicon Pharmaceuticals
Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica.
Bioorg Med Chem Lett 19: 6745-9 (2009)
Chosun University
5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase.
Bioorg Med Chem Lett 19: 6780-3 (2009)
Lexicon Pharmaceuticals
Discovery and optimization of substituted 1-(1-phenyl-1H-pyrazol-3-yl)methanamines as potent and efficacious type II calcimimetics.
J Med Chem 52: 6535-8 (2009)
Amgen
Crystal structure of 3-isopropylmalate dehydrogenase in complex with NAD(+) and a designed inhibitor.
Bioorg Med Chem 17: 7789-94 (2009)
Tokyo Institute Of Technology
The design of potent and selective inhibitors of DPP-4: optimization of ADME properties by amide replacements.
Bioorg Med Chem Lett 19: 6340-5 (2009)
Santhera Pharmaceuticals (Switzerland)
2'-Fluorosugar analogues of the highly potent anti-varicella-zoster virus bicyclic nucleoside analogue (BCNA) Cf 1743.
Bioorg Med Chem Lett 19: 6264-7 (2009)
Cardiff University
Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.
J Med Chem 52: 6946-50 (2009)
European Research Centre For Drug Discovery And Development (Natsyndrugs)
New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity.
J Med Chem 52: 6724-43 (2009)
Saarland University
Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a new L-type calcium channel blocker.
J Med Chem 52: 6637-48 (2009)
Universita Degli Studi Di Perugia
Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma.
J Med Chem 52: 6515-8 (2009)
Lexicon Pharmaceuticals
Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis.
J Biol Chem 284: 36137-45 (2009)
University Of Dundee
S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases.
J Med Chem 52: 6421-32 (2009)
Griffith University
Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control.
J Med Chem 52: 6362-8 (2009)
Vertex Pharmaceuticals
Structure-based design of DevR inhibitor active against nonreplicating Mycobacterium tuberculosis.
J Med Chem 52: 6324-34 (2009)
Indian Institute Of Medical Sciences
Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.
J Med Chem 52: 6193-6 (2009)
Novartis
Preparation and structural, biochemical, and pharmaceutical characterizations of bile acid-modified long-acting exendin-4 derivatives.
J Med Chem 52: 6889-96 (2009)
Sungkyunkwan University
New selective phosphodiesterase 4D inhibitors differently acting on long, short, and supershort isoforms.
J Med Chem 52: 6546-57 (2009)
University Of Genoa
Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1).
J Med Chem 52: 6941-5 (2009)
Clinical Research Institute Of Montreal
A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry.
Chembiochem 10: 2772-9 (2009)
University Of Cambridge
Carbonic anhydrase inhibitors: glycosylsulfanilamides act as subnanomolar inhibitors of the human secreted isoform VI.
Chem Biol Drug Des 74: 636-9 (2009)
Institut Des BiomolÉCules Max Mousseron (Ibmm)
Synthesis and biological evaluation of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core.
J Med Chem 52: 6660-71 (2009)
Fin-00014 University Of Helsinki
Aspergillusol A, an alpha-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus.
J Nat Prod 72: 2049-52 (2009)
Institute And The Center For Environmental Health
Synthesis and radiopharmacological investigation of 3-[4'-[(18)F]fluorobenzylidene]indolin-2-one as possible tyrosine kinase inhibitor.
Bioorg Med Chem 17: 7732-42 (2009)
Institute Of Radiopharmacy
Structure-based virtual screening approach to the discovery of novel inhibitors of factor-inhibiting HIF-1: identification of new chelating groups for the active-site ferrous ion.
Bioorg Med Chem 17: 7769-74 (2009)
Sejong University
1,3,4-Oxadiazole-2(3H)-thione and its analogues: a new class of non-competitive nucleotide pyrophosphatases/phosphodiesterases 1 inhibitors.
Bioorg Med Chem 17: 7816-22 (2009)
University Of Karachi
Inhibitors of bacterial N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity.
Bioorg Med Chem Lett 19: 6350-2 (2009)
Loyola University
Novel N-hydroxybenzamide-based HDAC inhibitors with branched CAP group.
Bioorg Med Chem Lett 19: 6284-8 (2009)
China Pharmaceutical University
Synthesis and biological evaluation of p38alpha kinase-targeting dialkynylimidazoles.
Bioorg Med Chem Lett 19: 6293-7 (2009)
The University Of Texas At Austin
Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction.
J Med Chem 52: 6768-81 (2009)
Research Triangle Institute
Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues.
J Med Chem 52: 6599-605 (2009)
Glaxosmithkline
Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).
J Med Chem 52: 6919-25 (2009)
Institute For Medical Research
Structure-activity relationships of 9-substituted-9-dihydroerythromycin-based motilin agonists: optimizing for potency and safety.
J Med Chem 52: 6851-9 (2009)
Kosan Biosciences
Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases.
J Med Chem 52: 6527-30 (2009)
Bristol-Myers Squibb Research And Development
Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone.
Bioorg Med Chem 17: 7690-7 (2009)
Philipps-Universit£T Marburg
Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D(3) (2MD) selectively eliminates bone calcium mobilization activity.
Bioorg Med Chem 17: 7658-69 (2009)
University Of Wisconsin-Madison
Identification of iminooxothiazolidines as secreted frizzled related protein-1 inhibitors.
Bioorg Med Chem Lett 19: 6337-9 (2009)
Wyeth Research
Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors.
Bioorg Med Chem Lett 19: 6307-12 (2009)
Amgen
Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain.
Bioorg Med Chem Lett 19: 6413-8 (2009)
Institute For Medical Research
Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog.
Bioorg Med Chem Lett 19: 6319-25 (2009)
Massachusetts General Hospital
Substituted 2-aminothiopen-derivatives: a potential new class of GluR6-antagonists.
Eur J Med Chem 45: 69-77 (2010)
Universit£T Leipzig
Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines.
Bioorg Med Chem Lett 19: 6368-72 (2009)
Merck Research Laboratories
Rapid access towards follow-up NOP receptor agonists using a knowledge based approach.
Bioorg Med Chem Lett 19: 6441-6 (2009)
Schering-Plough Research Institute
Identification of a critical residue in the transmembrane domain 2 of tachykinin neurokinin 3 receptor affecting the dissociation kinetics and antagonism mode of osanetant (SR 142801) and piperidine-based structures.
J Med Chem 52: 7103-12 (2009)
F. Hoffmann-La Roche
Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.
J Med Chem 52: 6931-5 (2009)
Mount Sinai School Of Medicine
Synthesis and biological evaluation of pyrrolopyridazine derivatives as novel HER-2 tyrosine kinase inhibitors.
Bioorg Med Chem Lett 19: 6437-40 (2009)
Shanghai Hengrui Pharmaceuticals
Scaffold-based design and synthesis of potent N-type calcium channel blockers.
Bioorg Med Chem Lett 19: 6467-72 (2009)
University Of Calgary
Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists II: tuning of receptor selectivity and in vivo efficacy.
Bioorg Med Chem Lett 19: 6376-8 (2009)
Johnson & Johnson Pharmaceutical Research And Development
Inhibition of the dimerization and active site of HIV-1 protease by secondary metabolites from the Vietnamese mushroom Ganoderma colossum.
J Nat Prod 72: 2019-23 (2009)
University Of Toyama
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.
J Med Chem 52: 7883-6 (2009)
University Of Bologna
Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury.
Bioorg Med Chem 17: 7477-86 (2009)
Dainippon Sumitomo Pharma
Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents.
Bioorg Med Chem Lett 19: 6386-91 (2009)
Elan Pharmaceuticals
Pyranocoumarins: a new class of anti-hyperglycemic and anti-dyslipidemic agents.
Bioorg Med Chem Lett 19: 6447-51 (2009)
Central Drug Research Institute
Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists I: discovery of CCKR1 selectivity in a previously CCKR2-selective lead series.
Bioorg Med Chem Lett 19: 6373-5 (2009)
Johnson & Johnson Pharmaceutical Research And Development
Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.
J Med Chem 52: 6649-59 (2009)
University Of Miami
Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B
J Med Chem 52: 6685-706 (2009)
Universita Degli Studi Di Bari
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.
Chem Biol Drug Des 74: 527-34 (2009)
University Of Notre Dame
Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds.
ACS Chem Biol 4: 939-47 (2009)
University Of Pittsburgh
7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.
J Med Chem 52: 6835-50 (2009)
The University Of Sydney
1,1'-Disubstituted ferrocenes as molecular hinges in mono- and bivalent dopamine receptor ligands.
J Med Chem 52: 6860-70 (2009)
Friedrich-Alexander University
The effects of C-terminal modifications on the opioid activity of [N-benzylTyr(1)]dynorphin A-(1-11) analogues.
J Med Chem 52: 6814-21 (2009)
University Of Kansas
Long-lasting enfuvirtide carrier pentasaccharide conjugates with potent anti-human immunodeficiency virus type 1 activity.
Antimicrob Agents Chemother 54: 134-42 (2009)
Endotis Pharma
Synthesis and in vitro evaluation of pteridine analogues as monoamine oxidase B and nitric oxide synthase inhibitors.
Bioorg Med Chem 17: 7523-30 (2009)
North-West University
Synthesis, molecular docking and biological evaluation of metronidazole derivatives as potent Helicobacter pylori urease inhibitors.
Bioorg Med Chem 17: 7531-6 (2009)
Nanjing University
Discovery and optimization of CRTH2 and DP dual antagonists.
Bioorg Med Chem Lett 19: 6419-23 (2009)
Amgen
Design of novel alpha7-subtype-preferring nicotinic acetylcholine receptor agonists: application of docking and MM-PBSA computational approaches, synthetic and pharmacological studies.
Bioorg Med Chem Lett 19: 6353-7 (2009)
Universit£
The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor.
Bioorg Med Chem Lett 19: 6452-8 (2009)
Glaxosmithkline
Phosphorylated hydroxyethylamines as novel inhibitors of the bacterial cell wall biosynthesis enzymes MurC to MurF.
Bioorg Chem 37: 217-22 (2009)
University Of Ljubljana
Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists.
J Med Chem 52: 6511-4 (2009)
Acadia Pharmaceuticals
Structure-based drug design identifies novel LPA3 antagonists.
Bioorg Med Chem 17: 7457-64 (2009)
The University Of Memphis
Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors.
Bioorg Med Chem 17: 7537-41 (2009)
Sookmyung Women'S University
Synthesis and structure-activity relationships of pyrazolodiazepine derivatives as human P2X7 receptor antagonists.
Bioorg Med Chem Lett 19: 6053-8 (2009)
Institute Of Science & Technology
N,N-Diethyl-4-[(3-hydroxyphenyl)(piperidin-4-yl)amino] benzamide derivatives: the development of diaryl amino piperidines as potent delta opioid receptor agonists with in vivo anti-nociceptive activity in rodent models.
Bioorg Med Chem Lett 19: 5994-8 (2009)
Astrazeneca R & D Montr£Al
Delta agonist hydroxy bioisosteres: the discovery of 3-((1-benzylpiperidin-4-yl){4-[(diethylamino)carbonyl]phenyl}amino)benzamide with improved delta agonist activity and in vitro metabolic stability.
Bioorg Med Chem Lett 19: 5999-6003 (2009)
Astrazeneca R & D Montr£Al
Insights into the inhibition of xanthine oxidase by curcumin.
Bioorg Med Chem Lett 19: 5990-3 (2009)
Shandong University Of Technology
Triazine and pyrimidine based ROCK inhibitors with efficacy in spontaneous hypertensive rat model.
Bioorg Med Chem Lett 19: 6027-31 (2009)
Ligand Pharmaceuticals
Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists.
Bioorg Med Chem Lett 19: 6018-22 (2009)
Schering-Plough Research Institute
Evaluation of triazolamers as active site inhibitors of HIV-1 protease.
Bioorg Med Chem Lett 19: 6023-6 (2009)
New York University
Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors.
Bioorg Med Chem Lett 19: 6157-60 (2009)
Sun Yat-Sen University
Discovery of novel sphingosine kinase 1 inhibitors.
Bioorg Med Chem Lett 19: 6119-21 (2009)
Genzyme
Effect of the structure of adenosine mimic of bisubstrate-analog inhibitors on their activity towards basophilic protein kinases.
Bioorg Med Chem Lett 19: 6098-101 (2009)
University Of Tartu
QSAR modeling of photosynthesis-inhibiting nostoclide derivatives.
Pest Manag Sci 66: 196-202 (2010)
Federal University Of Vi£Osa
Synthesis and binding affinity of potential atypical antipsychotics with the tetrahydroquinazolinone motif.
Bioorg Med Chem Lett 19: 6059-62 (2009)
Universidad De Santiago De Compostela
Piperazinyl-glutamate-pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation.
Bioorg Med Chem Lett 19: 6148-56 (2009)
Pfizer
Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases.
Bioorg Med Chem Lett 19: 6014-7 (2009)
Enscm-Umii-Cnrs 5635
Synthesis and anti-HIV-1 integrase activity of modified dinucleotides.
Eur J Med Chem 44: 5029-44 (2009)
Affiliated With The University Of Orl£Ans And With Inserm Rue Charles Sadron
Evaluation of spirocyclic 3-(3-fluoropropyl)-2-benzofurans as sigma1 receptor ligands for neuroimaging with positron emission tomography.
J Med Chem 52: 6062-72 (2009)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster
Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor.
J Med Chem 52: 6032-41 (2009)
Institute Of Organic Chemistry And Biochemistry Of The Ascr
Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene).
J Med Chem 52: 5950-66 (2009)
Arizona State University
Synthesis of 1,1-[1-naphthyloxy-2-thiophenyl]-2-methylaminomethylcyclopropanes and their evaluation as inhibitors of serotonin, norepinephrine, and dopamine transporters.
J Med Chem 52: 5872-9 (2009)
Oregon State University
Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors.
J Med Chem 52: 5864-71 (2009)
University Of Liege
RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.
J Med Chem 52: 5781-4 (2009)
Gilead Sciences
Kinase inhibitor data modeling and de novo inhibitor design with fragment approaches.
J Med Chem 52: 6456-66 (2009)
Eli Lilly
Synthesis and biological evaluation of 2-heteroarylthioalkanoic acid analogues of clofibric acid as peroxisome proliferator-activated receptor alpha agonists.
J Med Chem 52: 6224-32 (2009)
Universit£
Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists.
J Med Chem 52: 6297-313 (2009)
University Of Regensburg
Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors.
J Med Chem 52: 6369-81 (2009)
Clermont Universit£
Rational design and synthesis of potent dibenzazepine motifs as beta-secretase inhibitors.
J Med Chem 52: 6484-8 (2009)
University Of Sharjah
Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4).
J Med Chem 52: 6433-46 (2009)
University Of Zurich
Pentapeptides displaying mu opioid receptor agonist and delta opioid receptor partial agonist/antagonist properties.
J Med Chem 52: 7724-31 (2009)
University Of Michigan
Further studies on arylpiperazinyl alkyl pyridazinones: discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain.
J Med Chem 52: 7397-409 (2009)
Dipartimento Di Scienze Farmaceutiche
Benzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists.
Bioorg Med Chem Lett 19: 6106-13 (2009)
F. Hoffmann-La Roche
Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model.
J Med Chem 52: 6447-55 (2009)
University Of California
Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
J Med Chem 52: 6201-4 (2009)
Lexicon Pharmaceuticals
Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting.
Nat Chem Biol 5: 849-56 (2009)
Mcmaster University
Synthesis and evaluation of non-hydrolyzable D-mannose 6-phosphate surrogates reveal 6-deoxy-6-dicarboxymethyl-D-mannose as a new strong inhibitor of phosphomannose isomerases.
Bioorg Med Chem 17: 7100-7 (2009)
Univ Paris-Sud
Synthesis and evaluation of novel alpha-heteroaryl-phenylpropanoic acid derivatives as PPARalpha/gamma dual agonists.
Bioorg Med Chem 17: 7113-25 (2009)
Pfizer
Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors.
Bioorg Med Chem 17: 7156-73 (2009)
The University Of Sydney
Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: optimization of cellular potency.
Bioorg Med Chem Lett 19: 6135-9 (2009)
Johnson & Johnson Pharmaceutical Research And Development
Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett 19: 6122-6 (2009)
Harvard Medical School
Analogs of a 4-aminothieno[2,3-d]pyrimidine lead (QB13) as modulators of P-glycoprotein substrate specificity.
Bioorg Med Chem Lett 19: 6102-5 (2009)
University Of Bonn
Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: discovery, characterization and preliminary SAR of a promising lead.
Bioorg Med Chem Lett 19: 6185-8 (2009)
Novartis Institutes For Biomedical Research
Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects.
Bioorg Med Chem Lett 19: 6161-5 (2009)
Inha University
Discovery of 3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 - a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia [corrected]
Bioorg Med Chem Lett 19: 6225-9 (2009)
Fuji Yakuhin
Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-L-aspartic acid as inhibitors of aminopeptidase N/CD13.
Bioorg Med Chem 17: 7398-404 (2009)
Shandong University
Optimising metabolic stability in lipophilic chemical space: the identification of a metabolically stable pyrazolopyrimidine CRF-1 receptor antagonist.
Bioorg Med Chem Lett 19: 6144-7 (2009)
Pfizer
Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060.
Bioorg Med Chem Lett 19: 6095-7 (2009)
Silla University
Synthesis and evaluation of benzo[b]thiophene derivatives as inhibitors of alkaline phosphatases.
Bioorg Med Chem 17: 7290-300 (2009)
Universit£
Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors.
Bioorg Med Chem 17: 7174-85 (2009)
University Of California Los Angeles
Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors.
Bioorg Med Chem 17: 7368-80 (2009)
Universite De Lyon
Development of new and selective Trypanosoma cruzi trans-sialidase inhibitors from sulfonamide chalcones and their derivatives.
Chembiochem 10: 2475-9 (2009)
University Of British Columbia
Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.
J Med Chem 52: 7360-3 (2009)
Bristol-Myers Squibb
Pochonicine, a polyhydroxylated pyrrolizidine alkaloid from fungus Pochonia suchlasporia var. suchlasporia TAMA 87 as a potent beta-N-acetylglucosaminidase inhibitor.
Bioorg Med Chem 17: 7248-53 (2009)
Okayama University
2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
Bioorg Med Chem Lett 19: 6192-5 (2009)
University Of Oxford
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function.
J Med Chem 52: 6382-93 (2009)
Universit£
Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections.
J Med Chem 52: 7446-57 (2009)
Pfizer
Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase.
J Med Chem 52: 6467-73 (2009)
Purdue University
2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability.
J Med Chem 52: 6270-86 (2009)
Takeda Pharmaceutical
Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors.
J Med Chem 52: 6347-61 (2009)
Universit£
2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization.
Bioorg Med Chem 17: 7186-96 (2009)
Johann Wolfgang Goethe University
Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the cytosolic isoforms I and II.
Bioorg Med Chem 17: 7093-9 (2009)
Universita Degli Studi Di Firenze
Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.
Bioorg Med Chem Lett 19: 6218-21 (2009)
University Of California
Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements.
Bioorg Med Chem Lett 19: 6131-4 (2009)
Johnson & Johnson Pharmaceutical
Synthesis and structure-activity relationships of 2-(1,4'-bipiperidin-1'-yl)thiazolopyridine as H3 receptor antagonists.
Bioorg Med Chem Lett 19: 6176-80 (2009)
Schering-Plough Research Institute
Inhibitor profiling of the Pseudomonas aeruginosa virulence factor LasB using N-alpha mercaptoamide template-based inhibitors.
Bioorg Med Chem Lett 19: 6230-2 (2009)
Queen'S University Of Belfast
Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation.
Bioorg Med Chem Lett 19: 6166-71 (2009)
Arena Pharmaceuticals
Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold.
J Med Chem 52: 6197-200 (2009)
Imperial College
Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.
J Med Chem 52: 7488-502 (2009)
Chuq (Chul) Research Center And Laval University
p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression.
J Med Chem 52: 6257-69 (2009)
Glaxosmithkline
An approach to the site-selective diversification of apoptolidin A with peptide-based catalysts.
J Nat Prod 72: 1864-9 (2009)
Yale University
Structure-guided development of selective TbcatB inhibitors.
J Med Chem 52: 6489-93 (2009)
University Of California
Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity
J Med Chem 52: 7778-87 (2009)
Bristol-Myers Squibb Research And Development
Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase alpha inhibitors.
Bioorg Med Chem 17: 7227-38 (2009)
Kyoto Prefectural University
Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists.
Bioorg Med Chem Lett 19: 6237-40 (2009)
Merck Research Laboratories
Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors.
Bioorg Med Chem Lett 19: 6213-7 (2009)
Central Pharmaceutical Research Institute
Synthesis and in vitro autoradiographic evaluation of a novel high-affinity radioiodinated ligand for imaging brain cannabinoid subtype-1 receptors.
Bioorg Med Chem Lett 19: 6209-12 (2009)
National Institute Of Mental Health
PET-compatible endothelin receptor radioligands: synthesis and first in vitro and in vivo studies.
Bioorg Med Chem 17: 7197-208 (2009)
University Hospital M£Nster
Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline.
J Med Chem 52: 6189-92 (2009)
Amgen
The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.
Bioorg Med Chem 17: 7337-43 (2009)
University Of Arizona
Design, synthesis and evaluation of monovalent ligands for the asialoglycoprotein receptor (ASGP-R).
Bioorg Med Chem 17: 7254-64 (2009)
University Of Basel
The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction.
Bioorg Med Chem Lett 19: 5940-4 (2009)
F. Hoffmann-La Roche
Structure-activity relationship study on alpha1 adrenergic receptor antagonists from beer.
Bioorg Med Chem Lett 19: 5905-8 (2009)
University Of Shizuoka And Global Coe Program
Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs).
Bioorg Med Chem Lett 19: 5887-92 (2009)
Cytopia Research
First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors.
Bioorg Med Chem Lett 19: 5829-32 (2009)
Wyeth Research
The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase.
Bioorg Med Chem Lett 19: 5950-3 (2009)
Kudos Pharmaceuticals
Synthesis, SAR, and X-ray structure of tricyclic compounds as potent FBPase inhibitors.
Bioorg Med Chem Lett 19: 5909-12 (2009)
Daiichi Sankyo
Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide.
Eur J Med Chem 44: 4889-95 (2009)
Instituto De Qu£Mica M£Dica
Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.
J Med Chem 52: 6474-83 (2009)
National Human Genome Research Institute
Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase.
Bioorg Med Chem 17: 7301-12 (2009)
Shanghai Institutes For Biological Sciences
Indene-based frameworks targeting the 5-HT6 serotonin receptor: ring constraint in indenylsulfonamides using cyclic amines and structurally abbreviated counterparts.
Bioorg Med Chem 17: 7387-97 (2009)
Universitat De Barcelona
Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase.
Bioorg Med Chem Lett 19: 5864-8 (2009)
Boehringer Ingelheim Pharmaceuticals
The replacement of His(4) in angiotensin IV by conformationally constrained residues provides highly potent and selective analogues.
J Med Chem 52: 5612-8 (2009)
Vrije Universiteit Brussel
Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors.
J Med Chem 52: 6314-23 (2009)
Wyeth Research
Physical binding pocket induction for affinity prediction.
J Med Chem 52: 6107-25 (2009)
University Of California
Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor.
J Med Chem 52: 7808-16 (2009)
Ambit Biosciences
Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
J Med Chem 52: 6024-31 (2009)
University Of Minnesota
3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists.
Bioorg Med Chem 17: 7353-61 (2009)
Monash University (Parkville Campus)
The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors.
Bioorg Med Chem Lett 19: 5825-8 (2009)
Universita Degli Studi Di Firenze
Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase.
Bioorg Med Chem Lett 19: 5851-6 (2009)
Pfizer
Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.
Bioorg Med Chem 17: 7324-36 (2009)
Duquesne University
Thienopyrimidine-based P2Y12 platelet aggregation inhibitors.
Bioorg Med Chem Lett 19: 5919-23 (2009)
Pfizer
Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.
Bioorg Med Chem Lett 19: 5837-41 (2009)
Merck Frosst Centre For Therapeutic Research
Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate.
Bioorg Med Chem Lett 19: 5857-60 (2009)
Pfizer
Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2.
Bioorg Med Chem 17: 7281-9 (2009)
University Of Padova
Phosphoinositide-3-kinase (PI3K) inhibitors: identification of new scaffolds using virtual screening.
Bioorg Med Chem Lett 19: 5842-7 (2009)
University Of Auckland
Thienylhalomethylketones: Irreversible glycogen synthase kinase 3 inhibitors as useful pharmacological tools.
Bioorg Med Chem 17: 6914-25 (2009)
Instituto De Qu£Mica M£Dica-Csic
Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitors.
Bioorg Med Chem 17: 6926-36 (2009)
Astellas Pharma
Allosteric functional switch of neurokinin A-mediated signaling at the neurokinin NK2 receptor: structural exploration.
J Med Chem 52: 5999-6011 (2009)
Umr Uds/Cnrs 7200
Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase.
J Med Chem 52: 5880-95 (2009)
Boehringer Ingelheim Pharmaceuticals
Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance.
J Med Chem 52: 7689-705 (2009)
Purdue University
Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening.
J Med Chem 52: 5926-36 (2009)
Institut De Biologie Structurale Jean-Pierre Ebel (Cea/Cnrs/Ujf)
Synthesis and biological evaluation of novel phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors.
Bioorg Med Chem 17: 6959-70 (2009)
Kyoto 601-8550
Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities?
Bioorg Med Chem 17: 6898-907 (2009)
Friedrich-Schiller-Universit£T Jena
Characterization of the CHK1 allosteric inhibitor binding site.
Biochemistry 48: 9823-30 (2009)
Pfizer
Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain.
J Med Chem 52: 5785-8 (2009)
Glaxosmithkline
Structure-activity relationships for substrate-based inhibitors of human complement factor B.
J Med Chem 52: 6042-52 (2009)
The University Of Queensland
2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition.
J Med Chem 52: 7640-52 (2009)
Universit£
Structure-activity relationship and molecular mechanisms of ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4h-chromene-3-carboxylate (sha 14-1) and its analogues.
J Med Chem 52: 5937-49 (2009)
University Of Minnesota
Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression.
Bioorg Med Chem 17: 6890-7 (2009)
Human Biomolecular Research Institute
Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase.
Bioorg Med Chem Lett 19: 5872-6 (2009)
Bristol-Myers Squibb Research And Development
Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2.
Bioorg Med Chem Lett 19: 5893-7 (2009)
Pfizer
Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines as potent and highly selective GABAA alpha5 inverse agonists with potential for the treatment of cognitive dysfunction.
Bioorg Med Chem Lett 19: 5958-61 (2009)
F. Hoffmann-La Roche
Amiodarone and its putative metabolites fail to activate wild type hTAAR1.
Bioorg Med Chem Lett 19: 5913-4 (2009)
Rti International
Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists.
J Med Chem 52: 6153-7 (2009)
Universitat De Barcelona
Synthesis, conformational analysis, and biological evaluation of 19-nor-vitamin D3 analogues with A-ring modifications.
J Med Chem 52: 6158-62 (2009)
Universidad De Oviedo
5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103).
J Med Chem 52: 5803-15 (2009)
Amira Pharmaceuticals
Rapid generation of a high quality lead for transforming growth factor-beta (TGF-beta) type I receptor (ALK5).
J Med Chem 52: 7901-5 (2009)
Astrazeneca
The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators.
Bioorg Med Chem 17: 7042-51 (2009)
Banyu Tsukuba Research Institute
Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria.
Bioorg Med Chem 17: 6879-89 (2009)
Daiichi Sankyo
Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists.
Bioorg Med Chem Lett 19: 5931-5 (2009)
Adolor
Augmented photoswitching modulates immune signaling.
Nat Chem Biol 5: 724-6 (2009)
Max Planck Research Unit For Enzymology Of Protein Folding
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Bioorg Med Chem 17: 6983-92 (2009)
The University Of Texas
Identification and characterization of novel sirtuin inhibitor scaffolds.
Bioorg Med Chem 17: 7031-41 (2009)
Institute
Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor.
Bioorg Med Chem Lett 19: 5945-9 (2009)
Vernalis (R&D)
Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR.
Bioorg Med Chem Lett 19: 5898-901 (2009)
Kudos Pharmaceuticals
Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits.
J Med Chem 52: 7432-45 (2009)
Johnson & Johnson Pharmaceutical Research & Development
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.
J Med Chem 52: 5990-8 (2009)
Cnr
Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.
J Med Chem 52: 6097-106 (2009)
University Of Oxford
Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities.
Bioorg Med Chem 17: 6816-23 (2009)
Korea Research Institute Of Bioscience And Biotechnology
Identification of small molecule regulators of the nuclear receptor HNF4alpha based on naphthofuran scaffolds.
Bioorg Med Chem 17: 7021-30 (2009)
Universit£
Structure-based design of novel human Pin1 inhibitors (I).
Bioorg Med Chem Lett 19: 5613-6 (2009)
Pfizer
Structure-affinity relationships of glutamine mimics incorporated into phosphopeptides targeted to the SH2 domain of signal transducer and activator of transcription 3.
J Med Chem 52: 6126-41 (2009)
The University Of Texas M.D. Anderson Cancer Center
Synthesis of heteroaromatic tropeines and heterogeneous binding to glycine receptors.
Bioorg Med Chem 17: 6872-8 (2009)
Hungarian Academy Of Sciences
Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives.
Bioorg Med Chem 17: 6937-41 (2009)
The Chinese Academy Of Sciences
Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series.
Bioorg Med Chem Lett 19: 5746-52 (2009)
F. Hoffmann-La Roche
Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators.
Bioorg Med Chem Lett 19: 5531-8 (2009)
Banyu Tsukuba Research Institute
Prediction of telomerase inhibitory activity for acridinic derivatives based on chemical structure.
Eur J Med Chem 44: 4826-40 (2009)
Central University Of Las Villas
Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma.
J Med Chem 52: 5408-19 (2009)
Wyeth Research
Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives.
J Med Chem 52: 5311-22 (2009)
The Hong Kong Polytechnic University
Design and evaluation of novel biphenyl sulfonamide derivatives with potent histamine H(3) receptor inverse agonist activity.
J Med Chem 52: 5603-11 (2009)
Arena Pharmaceuticals
1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.
J Med Chem 52: 5703-11 (2009)
Wyeth Research
Nonclinical pharmacokinetics of oseltamivir and oseltamivir carboxylate in the central nervous system.
Antimicrob Agents Chemother 53: 4753-61 (2009)
F. Hoffmann-La Roche
Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist.
Bioorg Med Chem 17: 6971-82 (2009)
Tsukuba Research Institute
Potent small molecule mouse CD22-inhibitors: exploring the interaction of the residue at C-2 of sialic acid scaffold.
Bioorg Med Chem Lett 19: 5573-5 (2009)
Gifu University
Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia.
Bioorg Med Chem Lett 19: 5552-5 (2009)
Wyeth Research
Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX).
J Med Chem 52: 4968-72 (2009)
Eberhard Karls University Tuebingen
Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists.
J Med Chem 52: 4955-9 (2009)
Wyeth Research
Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity.
J Med Chem 52: 4951-4 (2009)
University Of Camerino
Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents.
J Med Chem 52: 4892-902 (2009)
Duquesne University
Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors.
J Med Chem 52: 4869-82 (2009)
Jt
Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree of unsaturation.
J Med Chem 52: 4631-9 (2009)
Wake Forest University
Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain.
J Med Chem 52: 4613-22 (2009)
Ghent University
Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening.
J Med Chem 52: 5578-81 (2009)
Universita Di Napoli "Federico Ii
Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1.
Nat Chem Biol 5: 758-64 (2009)
Universit£Tsklinikum Frankfurt
Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics.
Bioorg Med Chem Lett 19: 5528-30 (2009)
Institute Of Physiologically Active Compounds Russian Academy Of Sciences
The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages.
Bioorg Med Chem Lett 19: 5617-21 (2009)
Glaxosmithkline
Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents.
Eur J Med Chem 44: 4862-88 (2009)
Trinity College
Synthesis and pharmacological evaluation of novel N-alkyl/aryl substituted thiazolidinone arecoline analogues as muscarinic receptor 1 agonist in Alzheimer's dementia models.
Eur J Med Chem 44: 4848-54 (2009)
University Of Mysore
Synthesis and in vitro evaluation of 2,4-diamino-1,3,5-triazine derivatives as neuronal voltage-gated sodium channel blockers.
Bioorg Med Chem Lett 19: 5644-7 (2009)
National University Of Singapore
The discovery of thienopyridine analogues as potent IkappaB kinase beta inhibitors. Part II.
Bioorg Med Chem Lett 19: 5547-51 (2009)
Boehringer Ingelheim Pharmaceuticals
Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD.
Chem Biol 16: 849-61 (2009)
Burnham Institute For Medical Research
Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1.
Bioorg Med Chem 17: 6534-9 (2009)
University Of California
Design and synthesis of pyridazinone-based 5-HT(2C) agonists.
Bioorg Med Chem Lett 19: 5791-5 (2009)
Pfizer
GDC-0449-a potent inhibitor of the hedgehog pathway.
Bioorg Med Chem Lett 19: 5576-81 (2009)
Genentech
The first Hes1 dimer inhibitors from natural products.
Bioorg Med Chem Lett 19: 5778-81 (2009)
Chiba University
Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding.
Bioorg Med Chem Lett 19: 5594-8 (2009)
Exonhit Therapeutics
On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences.
J Med Chem 52: 5662-72 (2009)
University Of Duisburg-Essen
Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.
J Med Chem 52: 5732-47 (2009)
University Of Florida
Design, synthesis, and pharmacological activities of dynorphin A analogues cyclized by ring-closing metathesis.
J Med Chem 52: 5619-25 (2009)
The University Of Kansas
Inhibition of ribonuclease A by nucleoside-dibasic acid conjugates.
Bioorg Med Chem 17: 6491-5 (2009)
Institute Of Technology
Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.
Bioorg Med Chem Lett 19: 5803-6 (2009)
Merck Research Laboratories
Design, synthesis, and evaluation of novel 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective CXCR2 chemokine receptor antagonists.
Bioorg Med Chem Lett 19: 5741-5 (2009)
Wuxi Pharmatech
Structure-activity studies on seco-pancratistatin analogs: potent inhibitors of human cytochrome P450 3A4.
Bioorg Med Chem Lett 19: 5607-12 (2009)
Mcmaster University
Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors.
Bioorg Med Chem Lett 19: 5807-10 (2009)
Wyeth Research
Matrix metalloproteinase-2 inhibitors from Clinopodium chinense var. parviflorum.
J Nat Prod 72: 1379-84 (2009)
Tohoku Pharmaceutical University
Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors.
Bioorg Med Chem 17: 6505-11 (2009)
Universit£
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides.
Bioorg Med Chem Lett 19: 5652-6 (2009)
Roche Palo Alto
Synthesis of sigma receptor ligands with unsymmetrical spiro connection of the piperidine moiety.
Eur J Med Chem 44: 4306-14 (2009)
Institut F£R Pharmazeutische Und Medizinische Chemie
Conferin, potent antioxidant and anti-inflammatory isoflavone from Caragana conferta Benth.
J Enzyme Inhib Med Chem 25: 440-4 (2010)
University Of Karachi
N-hydroxybenzimidazole inhibitors of the transcription factor LcrF in Yersinia: novel antivirulence agents.
J Med Chem 52: 5626-34 (2009)
Paratek Pharmaceuticals
Synthesis and characterization of environment-sensitive fluorescent ligands for human 5-HT1A receptors with 1-arylpiperazine structure.
J Med Chem 52: 7892-6 (2009)
Universita Degli Studi Di Bari
Isoflavonoids from Erythrina poeppigiana: evaluation of their binding affinity for the estrogen receptor.
J Nat Prod 72: 1603-7 (2009)
University Of Athens
Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.
J Med Chem 52: 7836-46 (2009)
The Scripps Research Institute
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
Antimicrob Agents Chemother 53: 4640-6 (2009)
Yale University
Human immunodeficiency virus type 1 recombinant reverse transcriptase enzymes containing the G190A and Y181C resistance mutations remain sensitive to etravirine.
Antimicrob Agents Chemother 53: 4667-72 (2009)
Mcgill University Aids Centre
Synthesis and glycogen phosphorylase inhibitory activity of N-(beta-D-glucopyranosyl)amides possessing 1,4-benzodioxane moiety.
Bioorg Med Chem 17: 6738-41 (2009)
University Of Debrecen
Synthesis and biological evaluation of 4-fluoroproline and 4-fluoropyrrolidine-2-acetic acid derivatives as new GABA uptake inhibitors.
Bioorg Med Chem 17: 6540-6 (2009)
Institute Of Microbiology
C-5 substituted heteroaryl-3-pyridinecarbonitriles as PKCtheta inhibitors: part II.
Bioorg Med Chem Lett 19: 5799-802 (2009)
Wyeth Research
The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.
Bioorg Med Chem Lett 19: 5760-3 (2009)
Gsk Medicines Research Centre
Pharmacophore-guided lead optimization: the rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease.
Bioorg Med Chem Lett 19: 5811-3 (2009)
National Cancer Institute At Frederick
Structure-activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase.
Bioorg Med Chem Lett 19: 5773-7 (2009)
Sanford-Burnham Medical Research Institute
Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA).
Bioorg Med Chem Lett 19: 5712-5 (2009)
Berlex Biosciences
Novel CGRP receptor antagonists through a design strategy of target simplification with addition of molecular flexibility.
Bioorg Med Chem Lett 19: 5787-90 (2009)
Merck
Antiproliferative activity against MCF-7 breast cancer cells by diamino-triazaspirodiene antifolates.
Chem Biol Drug Des 74: 322-6 (2009)
National University Of Singapore
Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?
Chem Biol Drug Des 74: 317-21 (2009)
Istituto Di Biostrutture E Bioimmagini-Cnr
In silico screening for non-nucleoside HIV-1 reverse transcriptase inhibitors using physicochemical filters and high-throughput docking followed by in vitro evaluation.
Chem Biol Drug Des 74: 258-65 (2009)
University Of Jordan
Chemical Constituents of the Roots of Euphorbia micractina.
J Nat Prod 72: 1620-6 (2009)
Chinese Academy Of Medical Sciences And Peking Union Medical College
Eleven amino acid glucagon-like peptide-1 receptor agonists with antidiabetic activity.
J Med Chem 52: 7788-99 (2009)
Bristol-Myers Squibb
Development and biological activity of a new antagonist of the pheromone of the codling moth Cydia pomonella.
J Agric Food Chem 57: 8514-9 (2009)
University Of Lleida
Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists.
Bioorg Med Chem 17: 6567-82 (2009)
Ono Pharmaceutical
Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity.
Bioorg Med Chem 17: 6496-504 (2009)
Virginia Commonwealth University
mu-Opioid/5-HT4 dual pharmacologically active agents-efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I).
Bioorg Med Chem Lett 19: 5679-83 (2009)
Sepracor
Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine.
Bioorg Med Chem Lett 19: 5670-2 (2009)
Nagoya City University
Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett 19: 5703-7 (2009)
Pfizer
Amplification of the inhibitory activity of miglitol by monofluorination.
Bioorg Med Chem Lett 19: 5673-4 (2009)
Martin-Luther-Universit£T Halle-Wittenberg
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids.
Bioorg Med Chem Lett 19: 5648-51 (2009)
Roche Palo Alto
O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
Bioorg Med Chem Lett 19: 5632-5 (2009)
Chinese Academy Of Sciences
A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors.
Bioorg Med Chem Lett 19: 5716-21 (2009)
Merck Research Laboratories
Design, synthesis, screening, and molecular modeling study of a new series of ROS1 receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett 19: 5622-6 (2009)
University Of Science And Technology
Kojic acid-amino acid conjugates as tyrosinase inhibitors.
Bioorg Med Chem Lett 19: 5586-9 (2009)
Seoul National University
Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase.
Bioorg Med Chem 17: 6613-9 (2009)
Northern Kentucky University
Synthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum.
Bioorg Med Chem Lett 19: 5657-60 (2009)
Institute Infectious Diseases Initiative
Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1 receptor antagonists.
Bioorg Med Chem Lett 19: 5675-8 (2009)
Solvay Pharma
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
Bioorg Med Chem Lett 19: 5684-8 (2009)
Methylgene
Effectiveness and mode of action of phosphonate inhibitors of plant glutamine synthetase.
Pest Manag Sci 66: 51-8 (2010)
University Of Ferrara
Antagonists of the human A(2A) receptor. Part 6: Further optimization of pyrimidine-4-carboxamides.
Bioorg Med Chem 17: 6590-605 (2009)
Vernalis (R&D)
Identification of new agonists of urotensin-II from a cyclic peptide library.
Bioorg Med Chem 17: 6742-7 (2009)
Prism Bio. Lab.
Synthesis and evaluation of a full-agonist orvinol for PET-imaging of opioid receptors: [11C]PEO.
J Med Chem 52: 5586-9 (2009)
Biomedizinische Forschungsreagenzien
Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747).
J Med Chem 52: 5685-702 (2009)
Adolor
Recent advances in the identification of gamma-secretase inhibitors to clinically test the Abeta oligomer hypothesis of Alzheimer's disease.
J Med Chem 52: 6169-88 (2009)
Wyeth Research
Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors.
Bioorg Med Chem 17: 6692-8 (2009)
Zhejiang University
A new structural class of S-adenosylhomocysteine hydrolase inhibitors.
Bioorg Med Chem 17: 6707-14 (2009)
Boston College
Substituted 2-arylbenzothiazoles as kinase inhibitors: hit-to-lead optimization.
Bioorg Med Chem 17: 6728-37 (2009)
4Sc
Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: a potential treatment for psychotic disorders.
Bioorg Med Chem Lett 19: 5310-3 (2009)
Tsukuba Research Institute
Design and synthesis of piperazinylpyrimidinones as novel selective 5-HT(2C) agonists.
Bioorg Med Chem Lett 19: 5346-50 (2009)
Pfizer
Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors.
Bioorg Med Chem Lett 19: 5321-4 (2009)
Boehringer Ingelheim Pharmaceuticals
Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
J Med Chem 52: 5295-8 (2009)
East China University Of Science And Technology
Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2).
J Med Chem 52: 7878-82 (2009)
University Of Kentucky
Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases.
J Biol Chem 284: 28392-400 (2009)
Spanish National Cancer Research Center (Cnio)
Minor furanocoumarins and coumarins in grapefruit peel oil as inhibitors of human cytochrome P450 3A4.
J Nat Prod 72: 1702-4 (2009)
University Of Sao Paulo State
A critical electrostatic interaction mediates inhibitor recognition by human asparagine synthetase.
Bioorg Med Chem 17: 6641-50 (2009)
Kyoto University
Pyrrole[2,3-d]azepino compounds as agonists of the farnesoid X receptor (FXR).
Bioorg Med Chem Lett 19: 5289-92 (2009)
Wyeth Research
5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV.
Bioorg Med Chem Lett 19: 5302-6 (2009)
Pfizer
Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: potent, orally-active 1,4-disubstituted imidazoles.
Bioorg Med Chem Lett 19: 5351-4 (2009)
Pfizer
Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase.
Eur J Med Chem 44: 4855-61 (2009)
University Of Groningen
Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Design, chemistry and activity evaluation. Part I.
Eur J Med Chem 44: 4819-25 (2009)
Shandong University
Omega-conotoxin GVIA mimetics based on an anthranilamide core: effect of variation in ammonium side chain lengths and incorporation of fluorine.
Bioorg Med Chem 17: 6659-70 (2009)
The University Of Queensland
Synthesis and pharmacological evaluation of 6-naltrexamine analogs for alcohol cessation.
Bioorg Med Chem 17: 6671-81 (2009)
Human Biomolecular Research Institute
Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.
Bioorg Med Chem Lett 19: 5334-8 (2009)
Merck Research Laboratories
Discovery of novel diarylketoxime derivatives as selective and orally active melanin-concentrating hormone 1 receptor antagonists.
Bioorg Med Chem Lett 19: 5339-45 (2009)
Tsukuba Research Institute
A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease.
Anal Biochem 395: 195-204 (2009)
Novartis Institute For Tropical Diseases
Inhibition of S-ribosylhomocysteinase (LuxS) by substrate analogues modified at the ribosyl C-3 position.
Bioorg Med Chem 17: 6699-706 (2009)
Florida International University
Synthesis and pharmacological evaluation of novel 1- and 8-substituted-3-furfuryl xanthines as adenosine receptor antagonists.
Bioorg Med Chem 17: 6755-60 (2009)
Universidade De Santiago De Compostela
Synthesis and molecular modeling of some novel hexahydroindazole derivatives as potent monoamine oxidase inhibitors.
Bioorg Med Chem 17: 6761-72 (2009)
Hacettepe University
Spiro-naphthyridinone piperidines as inhibitors of S. aureus and E. coli enoyl-ACP reductase (FabI).
Bioorg Med Chem Lett 19: 5355-8 (2009)
Affinium Pharmaceuticals
2,3,4,5-Tetrahydro-1H-pyrido[2,3-b and e][1,4]diazepines as inhibitors of the bacterial enoyl ACP reductase, FabI.
Bioorg Med Chem Lett 19: 5359-62 (2009)
Affinium Pharmaceuticals
Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors.
Bioorg Med Chem Lett 19: 5314-20 (2009)
Merck Research Laboratories
C-5 Substituted heteroaryl 3-pyridinecarbonitriles as PKCtheta inhibitors: Part I.
Bioorg Med Chem Lett 19: 5423-5 (2009)
Wyeth Research
Photoregulation of thrombin aptamer activity using Bhc caging strategy.
Bioorg Med Chem Lett 19: 5368-71 (2009)
University Of Science And Technology Of China
Guttiferones O and P, prenylated benzophenone MAPKAPK-2 inhibitors from Garcinia solomonensis.
J Nat Prod 72: 1699-701 (2009)
Griffith University
Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation.
Bioorg Med Chem 17: 6180-7 (2009)
Uned
Synthesis and evaluation of inhibitors of cytochrome P450 3A (CYP3A) for pharmacokinetic enhancement of drugs.
Bioorg Med Chem Lett 19: 5444-8 (2009)
Abbott Laboratories
A novel class of highly potent multidrug resistance reversal agents: disubstituted adamantyl derivatives.
Bioorg Med Chem Lett 19: 5376-9 (2009)
Chung-Ang University
Molecular modeling studies to predict the possible binding modes of endomorphin analogs in mu opioid receptor.
Bioorg Med Chem Lett 19: 5387-91 (2009)
Lanzhou University
Identification of positron emission tomography ligands for NPY Y5 receptors in the brain.
Bioorg Med Chem Lett 19: 5436-9 (2009)
Tsukuba Research Institute
Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives.
Eur J Med Chem 44: 4288-96 (2009)
Jagiellonian University Medical College
Design, synthesis, and structure-activity relationships of aminopyridine N-oxides, a novel scaffold for the potent and selective inhibition of p38 mitogen activated protein kinase.
J Med Chem 52: 5531-45 (2009)
Almirall
Discovery of orally active 3-pyridinyl-tropane as a potent nociceptin receptor agonist for the management of cough.
J Med Chem 52: 5323-9 (2009)
Schering-Plough Research Institute
The nucleoside analogue D-carba T blocks HIV-1 reverse transcription.
J Med Chem 52: 5356-64 (2009)
Nci-Frederick
Synthesis of pentopyranosyl-containing thiodisaccharides. Inhibitory activity against beta-glycosidases.
Bioorg Med Chem 17: 6203-12 (2009)
Universidad De Buenos Aires
Disubstituted pyrimidines as Lck inhibitors.
Bioorg Med Chem Lett 19: 5440-3 (2009)
Merck Research Laboratories
Spiropiperidine CCR5 antagonists.
Bioorg Med Chem Lett 19: 5401-6 (2009)
Roche Palo Alto
From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs.
Bioorg Med Chem Lett 19: 5429-32 (2009)
Universit£
Discovery of a novel class of isoxazoline voltage gated sodium channel blockers.
Bioorg Med Chem Lett 19: 5329-33 (2009)
Merck Research Laboratories
Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist.
Bioorg Med Chem Lett 19: 5464-8 (2009)
Tsukuba Research Institute
Discovery of potential ZAP-70 kinase inhibitors: pharmacophore design, database screening and docking studies.
Eur J Med Chem 44: 4793-800 (2009)
Gvk Biosciences
Synthesis, biological evaluation, and three-dimensional in silico pharmacophore model for sigma(1) receptor ligands based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives.
J Med Chem 52: 5380-93 (2009)
University Of Trieste
Design, synthesis, and examination of neuron protective properties of alkenylated and amidated dehydro-silybin derivatives.
J Med Chem 52: 7732-52 (2009)
Pharmacy School Of Wenzhou Medical College
Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.
J Med Chem 52: 5449-61 (2009)
Wyeth Research
Inhibitors of aldose reductase and formation of advanced glycation end-products in moutan cortex (Paeonia suffruticosa).
J Nat Prod 72: 1465-70 (2009)
Chungnam National University
Synthetic partial agonists reveal key steps in IP3 receptor activation.
Nat Chem Biol 5: 631-9 (2009)
University Of Cambridge
Molecular modeling of human acidic mammalian chitinase in complex with the natural-product cyclopentapeptide chitinase inhibitor argifin.
Bioorg Med Chem 17: 6270-8 (2009)
Kitasato University
Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
Bioorg Med Chem 17: 6218-32 (2009)
Academy Of Sciences Of The Czech Republic
Solubilized phenyl-pyrazole ureas as potent, selective 5-HT(2A) inverse-agonists and their application as antiplatelet agents.
Bioorg Med Chem Lett 19: 5486-9 (2009)
Arena Pharmaceuticals
Dihydropyrazolopyrimidines containing benzimidazoles as K(V)1.5 potassium channel antagonists.
Bioorg Med Chem Lett 19: 5469-73 (2009)
Bristol-Myers Squibb
Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2.
Eur J Med Chem 44: 4702-15 (2009)
Medical University Of Warsaw
Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes.
Bioorg Med Chem 17: 6329-39 (2009)
The University Of Sydney
Synthesis and kinase inhibitory activity of novel substituted indigoids.
Bioorg Med Chem 17: 6257-63 (2009)
Universit£
Design and synthesis of new stabilized combi-triazenes for targeting solid tumors expressing the epidermal growth factor receptor (EGFR) or its closest homologue HER2.
Bioorg Med Chem Lett 19: 5505-9 (2009)
Mcgill University/Royal Victoria Hospital
Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C.
Bioorg Med Chem Lett 19: 5392-6 (2009)
Merck Frosst Canada
Synthesis of novel ageladine A analogs showing more potent matrix metalloproteinase (MMP)-12 inhibitory activity than the natural product.
Bioorg Med Chem Lett 19: 5461-3 (2009)
Kyorin Pharmaceutical
2-Amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2',3':4,5]thieno[2,3-b]pyridine derivatives as selective progesterone receptor agonists.
Bioorg Med Chem Lett 19: 4916-9 (2009)
Glaxosmithkline
Potent inhibitory effects of benzyl and p-xylidine-bis dithiocarbamate sodium salts on activities of mushroom tyrosinase.
J Enzyme Inhib Med Chem 25: 272-81 (2010)
University Of Tehran
Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.
Biochemistry 48: 8624-35 (2009)
The University Of Texas
A multivalent approach to the design and discovery of orally efficacious 5-HT4 receptor agonists.
J Med Chem 52: 5330-43 (2009)
Theravance
Probing the fibrate binding specificity of rat liver fatty acid binding protein.
J Med Chem 52: 5344-55 (2009)
Monash University
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.
J Med Chem 52: 5365-79 (2009)
Universitat De Barcelona
Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia.
J Med Chem 52: 5307-10 (2009)
Neurocrine Biosciences
Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs.
Bioorg Med Chem Lett 19: 5043-7 (2009)
The Schering Plough Research Institute
Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.
Bioorg Med Chem Lett 19: 4920-3 (2009)
Elan Pharmaceuticals
3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands.
Bioorg Med Chem 17: 6390-401 (2009)
University Of Copenhagen
Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration.
Bioorg Med Chem Lett 19: 5261-5 (2009)
Glaxosmithkline
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).
Blood 114: 2984-92 (2009)
Ambit Biosciences
14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition.
J Med Chem 52: 5069-75 (2010)
University Of Texas Southwestern Medical Center
Radiolabeled 5-iodo-3'-O-(17beta-succinyl-5alpha-androstan-3-one)-2'-deoxyuridine and its 5'-monophosphate for imaging and therapy of androgen receptor-positive cancers: synthesis and biological evaluation.
J Med Chem 52: 5124-43 (2010)
University Of Nebraska Medical Center
Curcumin inhibits ACTH- and angiotensin II-stimulated cortisol secretion and Ca(v)3.2 current.
J Nat Prod 72: 1533-7 (2009)
The Ohio State University College Of Medicine And Public Health
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo
J Med Chem 52: 5076-92 (2010)
RhôNe-Poulenc Rorer
Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.
Bioorg Med Chem Lett 19: 4929-32 (2009)
Universit£
Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
Bioorg Med Chem Lett 19: 5270-3 (2009)
Universitat De Barcelona
Design, synthesis and selection of DNA-encoded small-molecule libraries.
Nat Chem Biol 5: 647-54 (2009)
Praecis Pharmaceuticals
Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors.
Bioorg Med Chem 17: 6463-80 (2009)
Emory University
Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonists.
Bioorg Med Chem Lett 19: 5132-5 (2009)
Merck Research Laboratories
Identification of small molecule inhibitors of proline-rich tyrosine kinase 2 (Pyk2) with osteogenic activity in osteoblast cells.
Bioorg Med Chem Lett 19: 4924-8 (2009)
Amgen
Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxy phenoxy)ethylamino)propan-2-ol analogs and its enantiomers. Part 2.
Eur J Med Chem 44: 5103-11 (2009)
Rzesz£W University Of Technology
1,2,3-Selenadiazole thioacetanilides: synthesis and anti-HIV activity evaluation.
Bioorg Med Chem 17: 6374-9 (2009)
Shandong University
N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration.
Bioorg Med Chem Lett 19: 5078-81 (2009)
Pfizer
Novel CXCR3 antagonists with a piperazinyl-piperidine core.
Bioorg Med Chem Lett 19: 5205-8 (2009)
Ligand Pharmaceuticals
Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways.
Bioorg Med Chem 17: 6442-50 (2009)
University Of Medicine And Dentistry Of New Jersey-Robert Wood Johnson Medical School And The Informatics Institute Of Umdnj
Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors.
Bioorg Med Chem Lett 19: 5182-5 (2009)
Ambit Biosciences
Discovery of N-(3-(morpholinomethyl)-phenyl)-amides as potent and selective CB2 agonists.
Bioorg Med Chem Lett 19: 5004-8 (2009)
Adolor
2-Aminobenzimidazoles as potent Aurora kinase inhibitors.
Bioorg Med Chem Lett 19: 5158-61 (2009)
Sunesis Pharmaceuticals
Discovery of a novel azepine series of potent and selective 5-HT2C agonists as potential treatments for urinary incontinence.
Bioorg Med Chem Lett 19: 4999-5003 (2009)
Pfizer
Characterization of alpha-nitromethyl ketone as a new zinc-binding group based on structural analysis of its complex with carboxypeptidase A.
Bioorg Med Chem Lett 19: 5009-11 (2009)
Yanbian University
Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.
J Med Chem 52: 5009-12 (2010)
Merck Research Laboratories
Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease.
J Med Chem 52: 5228-40 (2009)
Purdue University
ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines
J Med Chem 52: 5013-6 (2009)
Wyeth Research
Novel flufenamic acid analogues as inhibitors of androgen receptor mediated transcription.
ACS Chem Biol 4: 834-43 (2009)
St. Jude Research Hospital
Design and discovery of 1,3-benzodiazepines as novel dopamine antagonists.
Bioorg Med Chem Lett 19: 5218-21 (2009)
Schering-Plough Research Institute
Design, synthesis and evaluation of novel 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4-substituted phenyl methanone analogues.
Bioorg Med Chem Lett 19: 5075-7 (2009)
Alwar Pharmacy College
Novel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor.
Bioorg Med Chem Lett 19: 5021-5 (2009)
Torrent Pharmaceuticals
Studies towards topical selective beta2-adrenoceptor agonists with a long duration of action.
Bioorg Med Chem Lett 19: 5237-40 (2009)
Boehringer Ingelheim Pharma
Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors.
Eur J Med Chem 44: 4496-508 (2009)
National Hellenic Research Foundation
Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase.
J Nat Prod 72: 1414-8 (2009)
China Pharmaceutical University
Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore.
J Med Chem 52: 5556-9 (2009)
University Of Cagliari
Synthesis and characterizations of novel quinoline derivatives having mixed ligand activities at the kappa and mu receptors: Potential therapeutic efficacy against morphine dependence.
Bioorg Med Chem 17: 5782-90 (2009)
Institute Of Chemical Biology
A comprehensive study on the 5-hydroxytryptamine(3A) receptor binding of agonists serotonin and m-chlorophenylbiguanidine.
Bioorg Med Chem 17: 5796-805 (2009)
Virtua Drug
Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors.
Bioorg Med Chem Lett 19: 5266-9 (2009)
Merck Frosst Center For Therapeutic Research
Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).
Bioorg Med Chem Lett 19: 4967-70 (2009)
Vanderbilt University Medical Center
A conformational constraint improves a beta-secretase inhibitor but for an unexpected reason.
Bioorg Med Chem Lett 19: 4993-5 (2009)
Merck Research Laboratories
Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter.
Bioorg Med Chem Lett 19: 4996-8 (2009)
University Of Glasgow
Synthesis and evaluation of a series of 2,4-diaminopyridine derivatives as potential positron emission tomography tracers for neuropeptide Y Y1 receptors.
Bioorg Med Chem Lett 19: 5124-7 (2009)
Tsukuba Research Institute
Pharmacophore modeling and virtual screening for the discovery of new transforming growth factor-beta type I receptor (ALK5) inhibitors.
Eur J Med Chem 44: 4259-65 (2009)
Sichuan University
6-methyl-2,4-disubstituted pyridazin-3(2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors.
J Med Chem 52: 5044-57 (2010)
Universita Degli Studi Di Firenze
Divergent modes of enzyme inhibition in a homologous structure-activity series.
J Med Chem 52: 5005-8 (2010)
University Of California
alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases.
Bioorg Med Chem 17: 5933-49 (2009)
Uppsala University
Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies.
Bioorg Med Chem Lett 19: 5056-9 (2009)
Imperial College
Semi-rigid tripeptide agonists of melanocortin receptors.
Bioorg Med Chem Lett 19: 5176-81 (2009)
University Of Cincinnati
Discovery of novel selective HER-2 sheddase inhibitors through optimization of P1 moiety.
Bioorg Med Chem Lett 19: 5037-42 (2009)
Incyte
Univalent and bivalent ligands of butorphan: characteristics of the linking chain determine the affinity and potency of such opioid ligands.
J Med Chem 52: 7389-96 (2009)
Harvard Medical School
Inhibition of a viral enzyme by a small-molecule dimer disruptor.
Nat Chem Biol 5: 640-6 (2009)
University Of California San Francisco
The search for potent, small molecule NNRTIs: A review.
Bioorg Med Chem 17: 5744-62 (2009)
The M.S. University Of Baroda
Optimization of a series of quinazolinone-derived antagonists of CXCR3.
Bioorg Med Chem Lett 19: 5114-8 (2009)
Amgen
Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists.
Bioorg Med Chem Lett 19: 5186-90 (2009)
Tsukuba Research Institute
Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)--Hit to Lead studies.
Bioorg Med Chem Lett 19: 5063-6 (2009)
Bristol-Myers Squibb Pharmaceutical Research And Development
Towards to hENT1-nucleoside transporter selective imaging agents. Synthesis and in vitro evaluation of the radiolabeled SAENTA analogues.
Bioorg Med Chem Lett 19: 5151-4 (2009)
Ulm University
Thiazole analog as stearoyl-CoA desaturase 1 inhibitor.
Bioorg Med Chem Lett 19: 5214-7 (2009)
Merck Frosst Centre For Therapeutic Research
Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B.
Bioorg Med Chem Lett 19: 5155-7 (2009)
Institute
Synthesis and evaluation of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonists.
Bioorg Med Chem Lett 19: 5195-9 (2009)
Merck Research Laboratories
Synthesis and evaluation of 2-amino-dihydrotetrabenzine derivatives as probes for imaging vesicular monoamine transporter-2.
Bioorg Med Chem Lett 19: 5026-8 (2009)
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
ADMET rules of thumb II: A comparison of the effects of common substituents on a range of ADMET parameters.
Bioorg Med Chem 17: 5906-19 (2009)
Glaxosmithkline
Fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D1.
Bioorg Med Chem 17: 6073-84 (2009)
University Of Leicester
4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: potent and selective p70S6 kinase inhibitors.
Bioorg Med Chem Lett 19: 5191-4 (2009)
Vertex Pharmaceuticals
4-Anilino-7-pyridyl-3-quinolinecarbonitriles as Src kinase inhibitors.
Bioorg Med Chem Lett 19: 5071-4 (2009)
Wyeth Research
Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols.
Bioorg Med Chem Lett 19: 5029-32 (2009)
Wyeth Research
Evaluation of hydrogen bonds of ecdysteroids in the ligand-receptor interactions using a protein modeling system.
Bioorg Med Chem 17: 5868-73 (2009)
Kyoto University
Design, synthesis, and discovery of novel non-peptide inhibitor of Caspase-3 using ligand based and structure based virtual screening approach.
Bioorg Med Chem 17: 6040-7 (2009)
Osmania University College For Women
Multiple strategies for the preparation of a sulfur-35 labeled NPC1L1 radioligand.
Bioorg Med Chem Lett 19: 5033-6 (2009)
Merck Research Laboratories
Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.
Bioorg Med Chem Lett 19: 5209-13 (2009)
Pfizer
Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors.
Bioorg Med Chem Lett 19: 5229-32 (2009)
Lexicon Pharmaceuticals
Design, syntheses, and evaluation of Taspase1 inhibitors.
Bioorg Med Chem Lett 19: 5086-90 (2009)
Stanford School Of Medicine
Imidazo-pyrazine derivatives as potent CXCR3 antagonists.
Bioorg Med Chem Lett 19: 5200-4 (2009)
Amgen
Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants.
Bioorg Med Chem Lett 19: 5119-23 (2009)
Merck Research Laboratory
Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90.
J Mol Biol 392: 923-36 (2009)
University College London
Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia (dagger) dagger Coordinates of the PDE10A crystal structures have been depo
J Med Chem 52: 5188-96 (2009)
Pfizer
Identification of enoxacin as an inhibitor of osteoclast formation and bone resorption by structure-based virtual screening.
J Med Chem 52: 5144-51 (2010)
University Of Florida College Of Medicine
Design, synthesis, and structure-activity relationship of tropane muscarinic acetylcholine receptor antagonists.
J Med Chem 52: 5241-52 (2010)
Glaxosmithkline
Structural basis for alpha-conotoxin potency and selectivity.
Bioorg Med Chem 17: 5894-9 (2009)
Boise State University
Design, synthesis and biological evaluation of novel pyridine derivatives as anticancer agents and phosphodiesterase 3 inhibitors.
Bioorg Med Chem 17: 5974-82 (2009)
German University In Cairo
Benzo[c][2,7]naphthyridines as inhibitors of PDK-1.
Bioorg Med Chem Lett 19: 5225-8 (2009)
Wyeth Research
Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors.
Bioorg Med Chem Lett 19: 5053-5 (2009)
Universidad De Santiago De Compostela
Probes for narcotic receptor mediated phenomena. 39. Enantiomeric N-substituted benzofuro[2,3-c]pyridin-6-ols: synthesis and topological relationship to oxide-bridged phenylmorphans.
J Med Chem 52: 7570-9 (2009)
National Institute On Drug Abuse And The National Institute On Alcohol Abuse And Alcoholi
Design and synthesis of novel nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors from caffeic acid phenethyl ester.
Bioorg Med Chem Lett 19: 4574-8 (2009)
Shandong University
Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives.
Bioorg Med Chem Lett 19: 4538-41 (2009)
Konkuk University
3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: optimization of selectivity and reduction of protein binding.
Bioorg Med Chem Lett 19: 4546-50 (2009)
Wyeth Research
The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors.
Bioorg Med Chem Lett 19: 4563-5 (2009)
Schering-Plough Research Institute
Triazole inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase.
J Med Chem 52: 4623-30 (2009)
Brandeis University
Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors.
J Med Chem 52: 7372-5 (2009)
The University Of Kansas
Enzymatic transition states and dynamic motion in barrier crossing.
Nat Chem Biol 5: 551-8 (2009)
Albert Einstein College Of Medicine
Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.
Bioorg Med Chem 17: 5834-56 (2009)
Universita Degli Studi Di Milano
Synthesis, biological evaluation, and metabolic stability of acrylamide derivatives as novel CCR3 antagonists.
Bioorg Med Chem 17: 5989-6002 (2009)
Astellas Pharma
Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normorphinan derivative.
Bioorg Med Chem 17: 5983-8 (2009)
Kitasato University
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.
J Med Chem 52: 4694-715 (2009)
Decode Biostructures
Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors.
Bioorg Med Chem 17: 5900-5 (2009)
Nagoya City University
The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling.
Bioorg Med Chem 17: 6032-9 (2009)
University Of Louisiana At Monroe
Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents.
Bioorg Med Chem 17: 5962-7 (2009)
Universit£
Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor.
Bioorg Med Chem 17: 6106-22 (2009)
Tsukuba Research Institute
Dihydroxy-pyrimidine and N-methylpyrimidone HIV-integrase inhibitors: improving cell based activity by the quaternarization of a chiral center.
Bioorg Med Chem Lett 19: 4617-21 (2009)
Irbm-Merck Research Laboratories Rome
Benzothiophene inhibitors of MK2. Part 1: structure-activity relationships, assessments of selectivity and cellular potency.
Bioorg Med Chem Lett 19: 4878-81 (2009)
Pfizer
Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD.
Bioorg Med Chem Lett 19: 4560-2 (2009)
Glaxosmithkline
Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency.
Bioorg Med Chem Lett 19: 4882-4 (2009)
Pfizer
Synthesis and biological evaluation of 1,2,4-trisubstituted imidazoles and 1,3,5-trisubstituted pyrazoles as inhibitors of transforming growth factor beta type 1 receptor (ALK5).
Bioorg Med Chem Lett 19: 4868-72 (2009)
Institute Of Pharmacology And Toxicology
3D-QSAR CoMFA/CoMSIA models based on theoretical active conformers of HOE/BAY-793 analogs derived from HIV-1 protease inhibitor complexes.
Eur J Med Chem 44: 4344-52 (2009)
Universidade Federal De Lavras
Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template.
Bioorg Med Chem Lett 19: 4579-83 (2009)
Pfizer
Design of selective Cathepsin inhibitors.
Bioorg Med Chem Lett 19: 4622-5 (2009)
Astrazeneca
Discovery of orally active, pyrrolidinone-based progesterone receptor partial agonists.
Bioorg Med Chem Lett 19: 4664-8 (2009)
Glaxosmithkline
Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells.
Bioorg Med Chem 17: 6048-53 (2009)
Kyoto Pharmaceutical University
In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives.
Bioorg Med Chem Lett 19: 4851-6 (2009)
Institute Of Pharmaceutical Sciences
The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin.
Bioorg Med Chem Lett 19: 4863-7 (2009)
Nagasaki International University
Discovery of imidazo[1,2-a]pyridines as potent MCH1R antagonists.
Bioorg Med Chem Lett 19: 4589-93 (2009)
Tsukuba Research Institute
Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors.
Bioorg Med Chem Lett 19: 4566-9 (2009)
Laboratorio De Radicales Libres Y QuÍMica Computacional (Iqog, Csic)
Investigation of the relative cellular permeability of DNA-binding pyrrole-imidazole polyamides.
J Med Chem 52: 4604-12 (2009)
University Of Texas Southwestern Medical Center
Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach.
J Med Chem 52: 4981-5004 (2010)
University Of South Florida
Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone.
J Med Chem 52: 4794-809 (2009)
Vernalis (R&D)
Inhibition of glyoxalase I: the first low-nanomolar tight-binding inhibitors.
J Med Chem 52: 4650-6 (2009)
University Of Minnesota
Novel indoline-based acyl-CoA: cholesterol acyltransferase inhibitor: Effects of introducing a methanesulfonamide group on physicochemical properties and biological activities.
Bioorg Med Chem 17: 6020-31 (2009)
Kyoto Pharmaceutical Industries
Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis.
Bioorg Med Chem Lett 19: 4647-51 (2009)
Amira Pharmaceuticals
Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)).
Bioorg Med Chem Lett 19: 4698-701 (2009)
University Of The West Of Scotland
Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and molecular modeling based on the solved X-ray structure of the beta2-adrenergic receptor: part 6.
Bioorg Med Chem Lett 19: 4679-83 (2009)
Astellas Pharma
Design, synthesis and preliminary biological evaluation of N-hydroxy-4-(3-phenylpropanamido)benzamide (HPPB) derivatives as novel histone deacetylase inhibitors.
Eur J Med Chem 44: 4470-6 (2009)
Shandong University
3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds.
J Med Chem 52: 4683-93 (2009)
Saarland University
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
J Med Chem 52: 4757-73 (2009)
Universit£
Design, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-selective androgen receptor modulators (SARMs).
J Med Chem 52: 4578-81 (2009)
Merck Research Laboratories
Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.
J Med Chem 52: 4923-35 (2009)
Friedrich-Alexander University
Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania.
J Med Chem 52: 7339-59 (2009)
University Of Bologna
Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines.
J Biol Chem 284: 25211-9 (2009)
University Of California San Francisco
Discovery of a novel protein kinase B inhibitor by structure-based virtual screening.
Bioorg Med Chem Lett 19: 4634-8 (2009)
Torrey Pines Institute For Molecular Studies
Synthesis and biological evaluation of imidazole derivatives as novel NOP/ORL1 receptor antagonists: exploration and optimization of alternative pyrazole structure.
Bioorg Med Chem Lett 19: 4611-6 (2009)
Banyu Tsukuba Research Institute
Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation.
Bioorg Med Chem Lett 19: 4657-63 (2009)
Pfizer
Identification of N,1,4,4-Tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor.
J Med Chem 52: 5152-63 (2009)
Nerviano Medical Sciences
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.
Nat Chem Biol 5: 749-57 (2009)
Indiana University
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Antimicrob Agents Chemother 53: 3715-9 (2009)
University Of Pittsburgh School Of Medicine
High-throughput screening identifies three inhibitor classes of the telomere resolvase from the lyme disease spirochete.
Antimicrob Agents Chemother 53: 4441-9 (2009)
University Of Calgary
Synthesis and evaluation of a novel 2-azabicyclo[2.2.2]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.
Bioorg Med Chem 17: 5639-47 (2009)
Tsukuba Research Institute
Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors.
Bioorg Med Chem Lett 19: 4715-9 (2009)
Dipartimento Di Chimica
Substituted pyrimidines as cannabinoid CB1 receptor ligands.
Bioorg Med Chem Lett 19: 4692-7 (2009)
Green Cross
Design, synthesis and biological evaluation of new potent and highly selective ROS1-tyrosine kinase inhibitor.
Bioorg Med Chem Lett 19: 4720-3 (2009)
Kyung Hee University
Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues.
Bioorg Med Chem 17: 5656-64 (2009)
University Of Minnesota
Design and synthesis of new 1,3-benzthiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.
Bioorg Med Chem 17: 5369-73 (2009)
Shahid Beheshti University (M.C)
Identification of potential cellular targets of aloisine A by affinity chromatography.
Bioorg Med Chem 17: 5572-82 (2009)
Cnrs Usr-3151
Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists.
Bioorg Med Chem Lett 19: 4781-5 (2009)
Tsukuba Research Institute
Muscarinic receptor 1 agonist activity of novel N-aryl carboxamide substituted 3-morpholino arecoline derivatives in Alzheimer's presenile dementia models.
Bioorg Med Chem 17: 5526-34 (2009)
University Of Mysore
7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents.
Bioorg Med Chem 17: 5396-407 (2009)
Universit£
Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile.
Bioorg Med Chem 17: 5549-64 (2009)
Sapienza University Of Rome
Synthesis and opioid receptor activity of indolopropellanes.
Bioorg Med Chem Lett 19: 4603-6 (2009)
Chinese Academy Of Sciences
Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.
Bioorg Med Chem Lett 19: 4777-80 (2009)
Glaxosmithkline
Parallel synthesis of potent dopaminergic N-phenyltriazole carboxamides applying a novel click chemistry based phenol linker.
Bioorg Med Chem 17: 5482-7 (2009)
Friedrich-Alexander University
Systematic syntheses of influenza neuraminidase inhibitors: a series of carbosilane dendrimers uniformly functionalized with thioglycoside-type sialic acid moieties.
Bioorg Med Chem 17: 5451-64 (2009)
Saitama University
Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists.
Bioorg Med Chem Lett 19: 4846-50 (2009)
Glaxosmithkline
Novel derivatives of ISO-1 as potent inhibitors of MIF biological function.
Bioorg Med Chem Lett 19: 4773-6 (2009)
Piramal Life Sciences
Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay.
Bioorg Med Chem Lett 19: 4706-10 (2009)
Meijo University
7-Azaindole-3-acetic acid derivatives: potent and selective CRTh2 receptor antagonists.
Bioorg Med Chem Lett 19: 4794-8 (2009)
Novartis Institutes Of Biomedical Research
Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors.
Bioorg Med Chem Lett 19: 4630-3 (2009)
Roche Palo Alto
Pyrazole acids as niacin receptor agonists for the treatment of dyslipidemia.
Bioorg Med Chem Lett 19: 4768-72 (2009)
Merck Research Laboratories
Synthesis and biological evaluation of guanidino compounds endowed with subnanomolar affinity as competitive inhibitors of maize polyamine oxidase.
J Med Chem 52: 4774-85 (2009)
Universit£
3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta.
J Med Chem 52: 7618-30 (2009)
Eberhard-Karls University
Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors.
Bioorg Med Chem Lett 19: 4673-8 (2009)
Banyu Tsukuba Research Institute
The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization.
J Med Chem 52: 4911-22 (2009)
University Of Copenhagen
Design of a new histamine H3 receptor antagonist chemotype: (3aR,6aR)-5-alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, synthesis, and structure-activity relationships.
J Med Chem 52: 4640-9 (2009)
Abbott Laboratories
Synthesis and characterization of 6-deoxy-6-fluoro-D-fructose as a potential compound for imaging breast cancer with PET.
Bioorg Med Chem 17: 5488-95 (2009)
University Of Alberta
FXR agonist activity of conformationally constrained analogs of GW 4064.
Bioorg Med Chem Lett 19: 4733-9 (2009)
Glaxosmithkline
Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.
J Med Chem 52: 7410-20 (2009)
Louvain Drug Research Institute
Discovery of novel thiourea derivatives as potent and selective beta3-adrenergic receptor agonists.
Bioorg Med Chem 17: 5510-9 (2009)
Astellas Pharma
The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists.
Bioorg Med Chem Lett 19: 4022-5 (2009)
Glaxosmithkline
Aromatic 2-(thio)ureidocarboxylic acids as a new family of modulators of multidrug resistance-associated protein 1: synthesis, biological evaluation, and structure-activity relationships.
J Med Chem 52: 4586-95 (2009)
University Of Bonn
Carbonic anhydrase-encoded dynamic constitutional libraries: toward the discovery of isozyme-specific inhibitors.
J Med Chem 52: 4853-9 (2009)
Enscm/Umii/Umr-Cnrs 5635
Nucleoside-5'-monophosphates as prodrugs of adenosine A2A receptor agonists activated by ecto-5'-nucleotidase.
J Med Chem 52: 7669-77 (2009)
University Of Bonn
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages.
Nat Chem Biol 5: 680-7 (2009)
University Of Pittsburgh
Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activation.
Bioorg Med Chem 17: 5683-7 (2009)
Kyushu University
Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase.
Bioorg Med Chem Lett 19: 4743-6 (2009)
Activx Biosciences
Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors.
Bioorg Med Chem Lett 19: 4070-4 (2009)
Gilead Sciences
The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists.
Bioorg Med Chem Lett 19: 4740-2 (2009)
Merck Research Laboratories
Synthesis, radiolabeling and preliminary in vivo evaluation of [18F]FE-PE2I, a new probe for the dopamine transporter.
Bioorg Med Chem Lett 19: 4843-5 (2009)
Institutet
Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists.
Eur J Med Chem 44: 4413-25 (2009)
Johnson & Johnson Pharmaceutical Research And Development
Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.
Bioorg Med Chem 17: 5583-97 (2009)
Institute For Molecular Studies
From lead to preclinical candidate: optimization of beta-homophenylalanine based inhibitors of dipeptidyl peptidase IV.
Bioorg Med Chem Lett 19: 4818-23 (2009)
Santhera Pharmaceuticals (Switzerland)
Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists.
Bioorg Med Chem Lett 19: 4747-51 (2009)
Pfizer
Design and synthesis of BACE-1 inhibitors utilizing a tertiary hydroxyl motif as the transition state mimic.
Bioorg Med Chem Lett 19: 4711-4 (2009)
Uppsala University
Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes.
Bioorg Med Chem 17: 5722-32 (2009)
Chinese Academy Of Sciences
Synergism of virtual screening and medicinal chemistry: identification and optimization of allosteric antagonists of metabotropic glutamate receptor 1.
Bioorg Med Chem 17: 5708-15 (2009)
Merz Pharmaceuticals
Glucose-based spiro-heterocycles as potent inhibitors of glycogen phosphorylase.
Bioorg Med Chem 17: 5696-707 (2009)
University Of Debrecen
Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase.
Bioorg Med Chem Lett 19: 4724-8 (2009)
Amgen
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the pathogenic yeast Candida glabrata with anions.
Bioorg Med Chem Lett 19: 4802-5 (2009)
Universit£
Novel inhibitors of the alphavbeta3 integrin--lead identification strategy.
Bioorg Med Chem Lett 19: 4832-5 (2009)
Astrazeneca
Determination of stereoselective interaction between enantiomers of chiral gamma-aryl-1H-1,2,4-triazole derivatives and Penicillium digitatum.
J Agric Food Chem 57: 6914-9 (2009)
Central China Normal University
Cytotoxic pentacyclic triterpenoids from Combretum sundaicum and Lantana camara as inhibitors of Bcl-xL/BakBH3 domain peptide interaction.
J Nat Prod 72: 1314-20 (2009)
Cnrs
Flaviviral protease inhibitors identified by fragment-based library docking into a structure generated by molecular dynamics.
J Med Chem 52: 4860-8 (2009)
University Of Zurich
Identification of inhibitors of checkpoint kinase 1 through template screening.
J Med Chem 52: 4810-9 (2009)
The Institute Of Cancer Research
9-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation.
J Med Chem 52: 4743-56 (2009)
Ariad Pharmaceuticals
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.
J Med Chem 52: 3994-4006 (2009)
Institute
Identification of MK-1925: a selective, orally active and brain-penetrable opioid receptor-like 1 (ORL1) antagonist.
Bioorg Med Chem Lett 19: 4729-32 (2009)
Tsukuba Research Institute
4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice.
Bioorg Med Chem Lett 19: 4455-8 (2009)
Chinese Academy Of Sciences
Synthesis and evaluation of 5-benzylidene(thio)barbiturate-beta-D-glycosides as mushroom tyrosinase inhibitors.
Bioorg Med Chem Lett 19: 4055-8 (2009)
Sun Yat-Sen University
Bioactivity-guided mapping and navigation of chemical space.
Nat Chem Biol 5: 585-92 (2009)
Institut FüR Molekulare Physiologie
Synthesis and biological evaluation of new 4-carboxyl quinoline derivatives as cyclooxygenase-2 inhibitors.
Bioorg Med Chem 17: 5312-7 (2009)
Shahid Beheshti University (M.C)
An extended study of dimeric phenyl tropanes.
Bioorg Med Chem 17: 4900-9 (2009)
Aarhus University
Conformationally restricted homotryptamines. Part 5: 3-(trans-2-aminomethylcyclopentyl)indoles as potent selective serotonin reuptake inhibitors.
Bioorg Med Chem Lett 19: 4031-3 (2009)
Bristol-Myers Squibb Pharmaceutical Research Institute
Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors.
Bioorg Med Chem Lett 19: 4026-30 (2009)
Grupo Uriach
Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue.
Bioorg Med Chem Lett 19: 4115-8 (2009)
Universit£
Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part one: lead identification.
Bioorg Med Chem Lett 19: 4799-801 (2009)
Cancer Therapeutics
Sulfonamides with the N-alkyl-N'-dialkylguanidine moiety as 5-HT7 receptor ligands.
Bioorg Med Chem Lett 19: 4827-31 (2009)
Jagiellonian University Medical College
In vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans.
Bioorg Med Chem 17: 4866-72 (2009)
University Of Connecticut
Discovery of a new class of catalytic topoisomerase II inhibitors targeting the ATP-binding site by structure based design. Part I.
Bioorg Med Chem Lett 19: 4014-7 (2009)
Novartis Institutes For Biomedical Research
Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( *) subtype.
Bioorg Med Chem Lett 19: 4359-63 (2009)
Targacept
Identification of new Hsp90 inhibitors by structure-based virtual screening.
Bioorg Med Chem Lett 19: 4839-42 (2009)
Seoul National University
'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity.
Bioorg Med Chem 17: 4873-80 (2009)
Chinese Academy Of Sciences
Synthesis of a novel series of benzylether-containing cinnamoyl derivatives as histone deacetylase inhibitors.
J Enzyme Inhib Med Chem 25: 132-8 (2010)
Shandong University
Tetrahydrocarbazole amides with potent activity against human papillomaviruses.
Bioorg Med Chem Lett 19: 4110-4 (2009)
Glaxosmithkline
Structural and theoretical studies of [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl)]-4-hydroxy-2-oxo-3-butenoïc acid as HIV-1 integrase inhibitor.
Bioorg Med Chem Lett 19: 4806-9 (2009)
Facult£S Universitaires Notre-Dame De La Paix
Discovery of a novel class of 2-mercaptohexanoic acid derivatives as highly active PPARalpha agonists.
Bioorg Med Chem Lett 19: 4421-6 (2009)
Goethe-University Frankfurt
Design, synthesis, and biological evaluation of 3,4,5-trimethoxyphenyl acrylamides as antinarcotic agents.
J Enzyme Inhib Med Chem 25: 38-43 (2010)
Ewha Womans University
Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
J Med Chem 52: 4511-23 (2009)
Burnham Institute For Medical Research
Tyrosinase-inhibitory constituents from the twigs of Cinnamomum cassia.
J Nat Prod 72: 1205-8 (2009)
Chungnam National University
Botryllamides: Natural Product Inhibitors of ABCG2.
ACS Chem Biol 4: 637-47 (2009)
Saic-Frederick
Cell division cycle 7 kinase inhibitors: 1H-pyrrolo[2,3-b]pyridines, synthesis and structure-activity relationships.
J Med Chem 52: 4380-90 (2009)
Nerviano Medical Sciences
Brain-penetrating 2-aminobenzimidazole H(1)-antihistamines for the treatment of insomnia.
Bioorg Med Chem Lett 19: 4380-4 (2009)
Neurocrine Biosciences
Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).
Bioorg Med Chem Lett 19: 4050-4 (2009)
Abbott Laboratories
Dopamine D(3) receptor antagonists: The quest for a potentially selective PET ligand. Part two: Lead optimization.
Bioorg Med Chem Lett 19: 4011-3 (2009)
Glaxosmithkline
Discovery and optimization of a novel Neuromedin B receptor antagonist.
Bioorg Med Chem Lett 19: 4264-7 (2009)
Amgen
Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3).
Bioorg Med Chem Lett 19: 4059-63 (2009)
Merck
Development of a selective and potent radioactive ligand for histamine H(3) receptors: A compound potentially useful for receptor occupancy studies.
Bioorg Med Chem Lett 19: 4075-8 (2009)
Tsukuba Research Institute
Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett 19: 4467-70 (2009)
Institute
Identification of aminoethyl pyrrolo dihydroisoquinolinones as novel poly(ADP-ribose) polymerase-1 inhibitors.
Bioorg Med Chem Lett 19: 4042-5 (2009)
Irbm-Merck Research Laboratories Rome
Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities.
Eur J Med Chem 44: 4235-43 (2009)
Sun Yat-Sen University
Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonists.
J Med Chem 52: 4173-91 (2009)
Bristol-Myers Squibb
In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists.
J Med Chem 52: 4161-72 (2009)
Bristol-Myers Squibb
Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
J Med Chem 52: 4288-305 (2009)
Serenex
Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.
J Med Chem 52: 4126-41 (2009)
Abbott Laboratories
Novel small molecule bradykinin B2 receptor antagonists.
J Med Chem 52: 4370-9 (2009)
Jerini
Carbonic anhydrase inhibitors: inhibition of cytosolic carbonic anhydrase isozymes II and VII with simple aromatic sulfonamides and some azo dyes.
Chem Biol Drug Des 74: 196-202 (2009)
Universita Degli Studi Di Firenze
Effect of some analgesics on paraoxonase-1 purified from human serum.
J Enzyme Inhib Med Chem 24: 1034-9 (2009)
AtatÜRk University
Synthesis, binding, and modeling studies of new cytisine derivatives, as ligands for neuronal nicotinic acetylcholine receptor subtypes.
J Med Chem 52: 4345-57 (2009)
Università
Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpoint.
Antimicrob Agents Chemother 53: 3690-9 (2009)
University Of Medicine And Dentistry Of New Jersey
Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription.
J Med Chem 52: 4277-87 (2009)
St. Jude Children'S Research Hospital
Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway.
Bioorg Med Chem 17: 4943-54 (2009)
University Of Leipzig
Optimization of peptide-based inhibitors of prostate-specific antigen (PSA) as targeted imaging agents for prostate cancer.
Bioorg Med Chem 17: 4888-93 (2009)
The Johns Hopkins University School Of Medicine
Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors.
Bioorg Med Chem Lett 19: 4196-200 (2009)
Irbm-Merck Research Laboratories Rome
Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation.
Bioorg Med Chem Lett 19: 4159-66 (2009)
Daiichi Sankyo
Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors.
Bioorg Med Chem Lett 19: 4034-41 (2009)
Bristol-Myers Squibb
Bioactive conformation analysis of cyclic imides as protoporphyrinogen oxidase inhibitor by combining DFT calculations, QSAR and molecular dynamic simulations.
Bioorg Med Chem 17: 4935-42 (2009)
Central China Normal University
Nucleoside-amino acid conjugates: An alternative route to the design of ribonuclease A inhibitors.
Bioorg Med Chem 17: 4921-7 (2009)
Institute Of Technology
Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening.
Bioorg Med Chem 17: 4861-5 (2009)
University Of Sydney
Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death.
Bioorg Med Chem 17: 5139-45 (2009)
National Human Genome Research Institute
Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.
Bioorg Med Chem 17: 5044-53 (2009)
University Of Arizona
Tetrahydroisoquinolines as dopaminergic ligands: 1-Butyl-7-chloro-6-hydroxy-tetrahydroisoquinoline, a new compound with antidepressant-like activity in mice.
Bioorg Med Chem 17: 4968-80 (2009)
Universidad De Valencia
Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide.
Bioorg Med Chem Lett 19: 4151-8 (2009)
Daiichi Sankyo
Aziridine alkaloids as potential therapeutic agents.
Eur J Med Chem 44: 3373-87 (2009)
Liverpool John Moores University
Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway.
Bioorg Med Chem Lett 19: 4191-5 (2009)
Irbm-Merck Research Laboratories Rome
Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.
Bioorg Med Chem Lett 19: 4088-91 (2009)
Pfizer
Discovery of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators.
Bioorg Med Chem Lett 19: 4450-4 (2009)
Banyu Tsukuba Research Institute
Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRalpha-selective antagonists.
Bioorg Med Chem 17: 5001-14 (2009)
The University Of Tokyo
Proteochemometrics mapping of the interaction space for retroviral proteases and their substrates.
Bioorg Med Chem 17: 5229-37 (2009)
Uppsala University
Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.
Bioorg Med Chem 17: 4894-9 (2009)
Istanbul University
A new small molecule that directly inhibits the DNA binding of NF-kappaB.
Bioorg Med Chem 17: 5293-7 (2009)
Tokushima Bunri University
Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors.
Bioorg Med Chem Lett 19: 4097-101 (2009)
Merck
Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.
Bioorg Med Chem Lett 19: 4092-6 (2009)
Pfizer
Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields.
Eur J Med Chem 44: 4179-91 (2009)
Helsinki University Of Technology
Identification of an orally active opioid receptor-like 1 (ORL1) receptor antagonist 4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-1-[(1S,3S,4R)-spiro[bicyclo[2.2.1]heptane-2,1'-cyclopropan]-3-ylmethyl]piperidine as clinical candidate.
J Med Chem 52: 4091-4 (2009)
Tsukuba Research Institute
Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines.
J Med Chem 52: 4103-6 (2009)
Vanderbilt University Medical Center
L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors.
J Med Chem 52: 4533-7 (2009)
Northwestern University
Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity.
J Med Chem 52: 3742-52 (2009)
St. Jude Children'S Research Hospital
Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase.
J Med Chem 52: 3652-65 (2009)
Academy Of Sciences Of The Czech Republic
Recent advances in the development of polyamine analogues as antitumor agents.
J Med Chem 52: 4551-73 (2009)
Johns Hopkins University
Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.
J Med Chem 52: 4266-76 (2009)
Astrazeneca
Identification of peptide substrate and small molecule inhibitors of testis-specific serine/threonine kinase1 (TSSK1) by the developed assays.
J Med Chem 52: 4419-28 (2009)
Chinese Academy Of Medical Sciences & Peking Union Medical College
Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice.
J Med Chem 52: 4496-510 (2009)
National Health Research Institutes
Discovery of a peroxisome proliferator activated receptor gamma (PPARgamma) modulator with balanced PPARalpha activity for the treatment of type 2 diabetes and dyslipidemia.
J Med Chem 52: 4443-53 (2009)
Merck Research Laboratories
Identification and biochemical characterization of small-molecule inhibitors of Clostridium botulinum neurotoxin serotype A.
Antimicrob Agents Chemother 53: 3478-86 (2009)
U.S. Army Medical Research Institute Of Infectious Diseases
Diketoacid-genre HIV-1 integrase inhibitors containing enantiomeric arylamide functionality.
Bioorg Med Chem 17: 5318-24 (2009)
National Cancer Institute-Frederick
Structure-activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide.
Bioorg Med Chem 17: 5080-95 (2009)
University Of Ferrara
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.
Bioorg Med Chem Lett 19: 4102-6 (2009)
University Of Tampere And Tampere University Hospital
Design, synthesis and evaluation of aspirin analogues having an additional carboxylate substituent for antithrombotic activity.
Bioorg Med Chem Lett 19: 4213-6 (2009)
Royal College Of Surgeons In Ireland
Chemical and biological investigation of cyclopropyl containing diaryl-pyrazole-3-carboxamides as novel and potent cannabinoid type 1 receptor antagonists.
J Med Chem 52: 4329-37 (2009)
Gedeon Richter
One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening.
J Med Chem 52: 4454-65 (2009)
University Of Dundee
Virtual screening approach for the identification of new Rac1 inhibitors.
J Med Chem 52: 4087-90 (2009)
Universit£
Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.
J Med Chem 52: 4391-9 (2009)
The University Of Queensland
Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode.
Bioorg Med Chem 17: 5336-41 (2009)
Gsk
Novel orally active NPY Y5 receptor antagonists: Synthesis and structure-activity relationship of spiroindoline class compounds.
Bioorg Med Chem 17: 5015-26 (2009)
Tsukuba Research Institute
[(11)C]PR04.MZ, a promising DAT ligand for low concentration imaging: Synthesis, efficient (11)C-O-methylation and initial small animal PET studies.
Bioorg Med Chem Lett 19: 4343-5 (2009)
Brookhaven National Laboratory
Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region.
Bioorg Med Chem Lett 19: 4446-9 (2009)
Schering-Plough Research Institute
N-[(Dihydroxyphenyl)acyl]serotonins as potent inhibitors of tyrosinase from mouse and human melanoma cells.
Bioorg Med Chem Lett 19: 4178-82 (2009)
National Institute Of Advanced Industrial Science And Technology
5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b.
Bioorg Med Chem Lett 19: 4207-9 (2009)
Arena Pharmaceuticals
Selective naphthalene H(3) receptor inverse agonists with reduced potential to induce phospholipidosis and their quinoline analogs.
Bioorg Med Chem Lett 19: 4495-500 (2009)
Hoffmann-La Roche
Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group.
Bioorg Med Chem Lett 19: 4171-4 (2009)
University Of Shizuoka And Global Coe Program
Diamine-based human histamine H3 receptor antagonists: (4-aminobutyn-1-yl)benzylamines.
Eur J Med Chem 44: 4098-106 (2009)
Johnson & Johnson Pharmaceutical Research & Development
Synthesis and structure-activity relationship of 3beta-(4-alkylthio, -methylsulfinyl, and -methylsulfonylphenyl)tropane and 3beta-(4-alkylthiophenyl)nortropane derivatives for monoamine transporters.
Bioorg Med Chem 17: 5126-32 (2009)
Research Triangle Institute
Synthesis of uracil nucleotide analogs with a modified, acyclic ribose moiety as P2Y(2) receptor antagonists.
Bioorg Med Chem 17: 5071-9 (2009)
University Of Bonn
Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists.
Bioorg Med Chem 17: 5153-63 (2009)
Wyeth Research
2D-QSAR and 3D-QSAR/CoMFA analyses of the N-terminal substituted anthranilic acid based CCK(1) receptor antagonists: 'Hic Rhodus, hic saltus'.
Bioorg Med Chem 17: 5198-206 (2009)
Aristotelian University Of Thessaloniki
A stabilized demethoxyviridin derivative inhibits PI3 kinase.
Bioorg Med Chem Lett 19: 4223-7 (2009)
Harvard Medical School
Prolonged stability by cyclization: Macrocyclic phosphino dipeptide isostere inhibitors of beta-secretase (BACE1).
Bioorg Med Chem Lett 19: 4427-31 (2009)
Technische Universit£T M£Nchen
Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach.
Bioorg Med Chem Lett 19: 4509-14 (2009)
Glaxosmithkline
N-(4-Fluorobenzyl)-3-hydroxy-9,9-dimethyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamides a novel class of potent HIV-1 integrase inhibitors.
Bioorg Med Chem Lett 19: 4245-9 (2009)
Irbm-Mrl
Synergistic effect of zanamivir-porphyrin conjugates on inhibition of neuraminidase and inactivation of influenza virus.
J Med Chem 52: 4903-10 (2009)
National Taiwan University
Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.
J Med Chem 52: 4111-4 (2009)
Tsukuba Research Institute
Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120).
J Med Chem 52: 4466-80 (2009)
Boehringer Ingelheim Pharma
Structural assessment and biological evaluation of two N3S bombesin derivatives.
J Med Chem 52: 4234-46 (2009)
Institutes Of Radioisotopes-Radiodiagnostic Products And Biology
Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926).
J Med Chem 52: 4400-18 (2009)
Infinity Pharmaceuticals
Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.
Bioorg Med Chem 17: 5219-28 (2009)
Hacettepe University
Synthesis of novel purine nucleosides towards a selective inhibition of human butyrylcholinesterase.
Bioorg Med Chem 17: 5106-16 (2009)
Faculdade De Ci£Ncias Da Universidade De Lisboa
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.
Bioorg Med Chem 17: 5054-8 (2009)
Centre Scientifique De Monaco
Unsymmetrical non-adamantyl N,N'-diaryl urea and amide inhibitors of soluble expoxide hydrolase.
Bioorg Med Chem Lett 19: 4259-63 (2009)
Arete Therapeutics
Synthesis, structure-activity relationships, and biological profiles of a dihydrobenzoxathiin class of histamine H(3) receptor inverse agonists.
Bioorg Med Chem Lett 19: 4232-6 (2009)
Tsukuba Research Institute
Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.
Bioorg Med Chem Lett 19: 4504-8 (2009)
Glaxosmithkline
Discovery and functional evaluation of diverse novel human CB(1) receptor ligands.
Bioorg Med Chem Lett 19: 4183-90 (2009)
Vernalis (R&D)
Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin.
J Mol Biol 391: 552-64 (2009)
Philipps University Marburg
Potent triazolothione inhibitor of heat-shock protein-90.
Chem Biol Drug Des 74: 43-50 (2009)
Bayer Healthcare
Novel 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1) and 3beta-methoxyserrat-14-en-21beta-ol (PJ-2)-curcumin, kojic acid, quercetin, and baicalein conjugates as HIV agents.
Bioorg Med Chem 17: 5238-46 (2009)
Osaka University Of Pharmaceutical Sciences
Synthesis and biological evaluation of (11)C-labeled beta-galactosyl triazoles as potential PET tracers for in vivo LacZ reporter gene imaging.
Bioorg Med Chem 17: 5117-25 (2009)
Katholieke Universiteit Leuven
SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist.
Bioorg Med Chem 17: 5247-58 (2009)
Wyeth Research
Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase.
Bioorg Med Chem Lett 19: 4350-3 (2009)
Glaxosmithkline
Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.
Bioorg Med Chem Lett 19: 4241-4 (2009)
Vernalis (R&D)
Dipeptidyl nitrile inhibitors of Cathepsin L.
Bioorg Med Chem Lett 19: 4280-3 (2009)
Astrazeneca
Discovery of beta-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV.
Bioorg Med Chem Lett 19: 4201-3 (2009)
Santhera Pharmaceuticals (Switzerland)
HIF-1alpha peptide derivatives with modifications at the hydroxyproline residue as activators of HIF-1alpha.
Bioorg Med Chem Lett 19: 4403-5 (2009)
Institute Of Science And Technology
Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model.
J Med Chem 52: 7364-7 (2009)
Incyte
Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma a
J Med Chem 52: 3846-54 (2009)
Merck Research Laboratories
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action.
Bioorg Med Chem Lett 19: 4312-5 (2009)
Alma Mater Studiorum-Bologna University
Synthesis and structure-activity relationships of gamma-carboline derivatives as potent and selective cysLT(1) antagonists.
Bioorg Med Chem Lett 19: 4299-302 (2009)
Universitat De Barcelona
Eusynstyelamides A, B, and C, nNOS inhibitors, from the ascidian Eusynstyela latericius.
J Nat Prod 72: 1115-20 (2009)
Institute Of Marine Science
Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose.
Bioorg Med Chem 17: 5298-311 (2009)
National Institute Of Diabetes And Digestive And Kidney Diseases
Application of a 3,3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors.
Bioorg Med Chem Lett 19: 4228-31 (2009)
The University Of Tokyo
Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives as novel small molecule chaperone amplifiers.
Bioorg Med Chem Lett 19: 4303-7 (2009)
Cytrx
Identification of a chromone-based retinoid containing a polyolefinic side chain via facile synthetic routes.
Bioorg Med Chem Lett 19: 4339-42 (2009)
Temple University
Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites.
Bioorg Med Chem 17: 5259-74 (2009)
Universit£
SAR of a series of inhaled A(2A) agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data.
Bioorg Med Chem Lett 19: 4471-5 (2009)
Pfizer
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.
Bioorg Med Chem 17: 5182-8 (2009)
University Of Alberta
Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents.
Bioorg Med Chem 17: 5285-92 (2009)
Central Drug Research Institute
Optimization of piperidin-4-yl-urea-containing melanin-concentrating hormone receptor 1 (MCH-R1) antagonists: Reducing hERG-associated liabilities.
Bioorg Med Chem Lett 19: 4274-9 (2009)
Astrazeneca R & D M£Lndal
Rapid assessment of a novel series of selective CB(2) agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis.
Bioorg Med Chem Lett 19: 4406-9 (2009)
Pfizer
Optimization of 2-piperidin-4-yl-acetamides as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists: Designing out hERG inhibition.
Bioorg Med Chem Lett 19: 4268-73 (2009)
Astrazeneca R & D M£Lndal
Structure-based virtual screening approach to identify novel classes of Cdc25B phosphatase inhibitors.
Bioorg Med Chem Lett 19: 4372-5 (2009)
Sejong University
An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors.
Eur J Med Chem 44: 4121-7 (2009)
Universidade De Coimbra
Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives.
Eur J Med Chem 44: 4004-9 (2009)
Universidade Federal Do Rio De Janeiro
Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system.
J Med Chem 52: 7580-92 (2009)
National Institute Of Diabetes And Digestive And Kidney Diseases
A small-molecule inhibitor of Nipah virus envelope protein-mediated membrane fusion.
J Med Chem 52: 4257-65 (2009)
University Of W£Rzburg
Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors.
Bioorg Med Chem Lett 19: 4441-5 (2009)
Glaxosmithkline
Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors.
Bioorg Med Chem Lett 19: 4330-4 (2009)
Sejong University
QSAR study of Akt/protein kinase B (PKB) inhibitors using support vector machine.
Eur J Med Chem 44: 4090-7 (2009)
Zhejiang University
Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylcholinesterase.
Eur J Med Chem 44: 4057-62 (2009)
University Of Mysore
Synthesis and evaluation of A-seco type triterpenoids for anti-HIV-1protease activity.
Eur J Med Chem 44: 4112-20 (2009)
University Of Toyama
Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.
J Med Chem 52: 3474-83 (2009)
Friedrich Alexander University Erlangen
Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists.
ACS Chem Biol 4: 557-66 (2009)
Genentech
Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues.
J Med Chem 52: 3982-93 (2009)
Glaxosmithkline
Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders.
J Med Chem 52: 3941-53 (2009)
Lexicon Pharmaceuticals
Discovery of novel aminothiadiazole amides as selective EP(3) receptor antagonists.
Bioorg Med Chem Lett 19: 4292-5 (2009)
Glaxosmithkline
Optimization of a series of 2,4-diaminopyridines as neuropeptide Y Y1 receptor antagonists with reduced hERG activity.
Bioorg Med Chem Lett 19: 4325-9 (2009)
Tsukuba Research Institute
Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy.
J Med Chem 52: 4095-8 (2009)
Institute Of Science
Scalarane-based sesterterpenoid RCE-protease inhibitors isolated from the Indonesian marine sponge Carteriospongia foliascens.
J Nat Prod 72: 1106-9 (2009)
University Of British Columbia
Phage-encoded combinatorial chemical libraries based on bicyclic peptides.
Nat Chem Biol 5: 502-7 (2009)
Laboratory Of Molecular Biology, Medical Research Council
Retinoid receptor subtype-selective modulators through synthetic modifications of RARgamma agonists.
Bioorg Med Chem 17: 4345-59 (2009)
Universidade De Vigo
Bicyclic cyanothiazolidines as novel dipeptidyl peptidase 4 inhibitors.
Bioorg Med Chem Lett 19: 4437-40 (2009)
Phenomix
Synthesis and bioactivity of substituted indan-1-ylideneaminoguanidine derivatives.
Eur J Med Chem 44: 3771-6 (2009)
China Pharmaceutical University
Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins.
Bioorg Med Chem 17: 4360-6 (2009)
National Taiwan University
Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomography.
Bioorg Med Chem 17: 4367-77 (2009)
The Johns Hopkins University School Of Medicine
Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors.
Bioorg Med Chem 17: 4280-4 (2009)
Hokkaido University
Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases.
Bioorg Med Chem 17: 4448-58 (2009)
Friedrich-Alexander-Universit£T
Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors.
Bioorg Med Chem Lett 19: 3398-404 (2009)
Merck Research Laboratories
Novel and potent small-molecule urotensin II receptor agonists.
Bioorg Med Chem 17: 4657-65 (2009)
University Of Gothenburg
Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation.
Bioorg Med Chem 17: 4459-65 (2009)
Karl-Franzens-Universit£T Graz
Synthesis and biological evaluation of novel 4-azaindolyl-indolyl-maleimides as glycogen synthase kinase-3beta (GSK-3beta) inhibitors.
Bioorg Med Chem 17: 4302-12 (2009)
Zhejiang University
Discovery of novel motilin antagonists: Conversion of tetrapeptide leads to orally available peptidomimetics.
Bioorg Med Chem Lett 19: 3426-9 (2009)
Chugai Pharmaceutical
Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors.
Bioorg Med Chem Lett 19: 3405-9 (2009)
Schering-Plough Research Institute
Novel sulfone-containing di- and trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists.
Bioorg Med Chem Lett 19: 3418-22 (2009)
Bristol-Myers Squibb
Synthesis of novel phosphorothioates and phosphorodithioates and their differential inhibition of cholinesterases.
Bioorg Chem 37: 101-5 (2009)
Institute For Advanced Studies In Basic Sciences (Iasbs)
Isoform-specific inhibition of cyclophilins.
Biochemistry 48: 6268-77 (2009)
Max Planck Research
Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases.
Bioorg Med Chem 17: 4466-76 (2009)
Microbiotix
Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins.
Bioorg Med Chem 17: 4420-4 (2009)
Clermont Universit£
Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.
Bioorg Med Chem Lett 19: 3669-73 (2009)
Gsk
QSAR study on maximal inhibition (Imax) of quaternary ammonium antagonists for S-(-)-nicotine-evoked dopamine release from dopaminergic nerve terminals in rat striatum.
Bioorg Med Chem 17: 4477-85 (2009)
University Of Kentucky
Synthesis of quinolinyl and isoquinolinyl phenyl ketones as novel agonists for the cannabinoid CB2 receptor.
Bioorg Med Chem 17: 4441-7 (2009)
Helsinki University Of Technology
Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds.
J Nat Prod 72: 1220-30 (2009)
Ghent University-Ugent
Chemical constituents from the aerial parts of Artemisia minor.
J Nat Prod 72: 1198-201 (2009)
Chinese Academy Of Sciences
Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors.
Bioorg Med Chem 17: 4523-36 (2009)
Cobra
Synthesis and pharmacological evaluation of 1,2,3,4-tetrahydropyrazino[1,2-a]indole and 2-[(phenylmethylamino)methyl]-1H-indole analogues as novel melatoninergic ligands.
Bioorg Med Chem 17: 4583-94 (2009)
University Of W£Rzburg
N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275.
Bioorg Med Chem Lett 19: 3493-7 (2009)
Pfizer
Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor.
J Med Chem 52: 3627-35 (2009)
University Of Arizona
Further studies at neuropeptide s position 5: discovery of novel neuropeptide S receptor antagonists.
J Med Chem 52: 4068-71 (2009)
National Institute Of Neuroscienc
Novel potent BRAF inhibitors: toward 1 nM compounds through optimization of the central phenyl ring.
J Med Chem 52: 3881-91 (2009)
The Institute Of Cancer Research
Design of HIV-1 protease inhibitors with pyrrolidinones and oxazolidinones as novel P1'-ligands to enhance backbone-binding interactions with protease: synthesis, biological evaluation, and protein-ligand X-ray studies.
J Med Chem 52: 3902-14 (2009)
Purdue University
Competitive inhibition of human poly(A)-specific ribonuclease (PARN) by synthetic fluoro-pyranosyl nucleosides.
Biochemistry 48: 6044-51 (2009)
University Of Thessaly
Curcumin modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungals.
Antimicrob Agents Chemother 53: 3256-65 (2009)
Jawaharlal Nehru University
Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge.
Antimicrob Agents Chemother 53: 4051-63 (2009)
University Of Notre Dame
Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).
J Med Chem 52: 4115-8 (2009)
Vanderbilt University Medical Center
Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors.
J Med Chem 52: 3892-901 (2009)
St. Jude Children'S Hospital
1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity.
J Med Chem 52: 3954-68 (2009)
Novartis Institutes For Biomedical Research
Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases.
J Med Chem 52: 3618-26 (2009)
National University Of Singapore
Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor.
J Med Chem 52: 3723-34 (2009)
Universita Di Pisa
Discovery of novel lipophilic inhibitors of OXA-10 enzyme (class D beta-lactamase) by screening amino analogs and homologs of citrate and isocitrate.
Bioorg Med Chem Lett 19: 3593-7 (2009)
Universit£
Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs).
Bioorg Med Chem Lett 19: 3602-6 (2009)
Glaxosmithkline
Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands.
Eur J Med Chem 44: 3880-8 (2009)
Universit£
Iodophenyl tagged sphingosine derivatives: synthesis and preliminary biological evaluation.
Bioorg Med Chem Lett 19: 3382-5 (2009)
University Of Pennsylvania
Carbamates as potent calcitonin gene-related peptide antagonists with improved solution stability.
Bioorg Med Chem Lett 19: 3555-8 (2009)
Bristol-Myers Squibb Research And Development
Inhibitor hijacking of Akt activation.
Nat Chem Biol 5: 484-93 (2009)
University Of California
6-Amino-2-mercapto-3H-pyrimidin-4-one derivatives as new candidates for the antagonism at the P2Y12 receptors.
Bioorg Med Chem 17: 4612-21 (2009)
Universit£
Identification of novel serotonin 2C receptor ligands by sequential virtual screening.
Bioorg Med Chem 17: 4559-68 (2009)
Institute Of Science And Technology
Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists.
Bioorg Med Chem Lett 19: 3511-6 (2009)
Tsukuba Research Institute
Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors.
Bioorg Med Chem Lett 19: 3686-92 (2009)
National Human Genome Research Institute
Synthesis and activity of quinolinylmethyl P1' alpha-sulfone piperidine hydroxamate inhibitors of TACE.
Bioorg Med Chem Lett 19: 3445-8 (2009)
Wyeth Research
Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood.
Bioorg Med Chem Lett 19: 3485-8 (2009)
Wyeth Research
Synthesis and structure-activity relationships of N-(4-amino-2,6-diisopropylphenyl)-N'-(1,4-diarylpiperidine-4-yl)methylureas as anti-hyperlipidemic agents.
Bioorg Med Chem 17: 4636-46 (2009)
Dainippon Sumitomo Pharma
Structure-activity relationships of heteroaromatic esters as human rhinovirus 3C protease inhibitors.
Bioorg Med Chem Lett 19: 3632-6 (2009)
Institute Of Science And Technology
Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208.
Bioorg Med Chem Lett 19: 3647-50 (2009)
Adolor
Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma.
Bioorg Med Chem Lett 19: 3550-4 (2009)
Amgen
Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.
J Med Chem 52: 3703-15 (2009)
University Of Washington
High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors.
J Med Chem 52: 3784-93 (2009)
University Of Bonn
Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc.
J Med Chem 52: 3915-26 (2009)
Chemical Genomics Centre Of The Max Planck Society
Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles.
J Med Chem 52: 3762-73 (2009)
The University Of Newcastle
Discovery of tetrasubstituted imidazolines as potent and selective neuropeptide Y Y5 receptor antagonists: reduced human ether-a-go-go related gene potassium channel binding affinity and potent antiobesity effect.
J Med Chem 52: 3385-96 (2009)
Tsukuba Research Institute
Sesterterpenes as tubulin tyrosine ligase inhibitors. First insight of structure-activity relationships and discovery of new lead.
J Med Chem 52: 3814-28 (2009)
Universita Di Salerno
The structure-based design, synthesis, and biological evaluation of DNA-binding amide linked bisintercalating bisanthrapyrazole anticancer compounds.
Bioorg Med Chem 17: 4575-82 (2009)
University Of Manitoba
Hit-to-lead optimization of pyrrolo[1,2-a]quinoxalines as novel cannabinoid type 1 receptor antagonists.
Bioorg Med Chem Lett 19: 3471-5 (2009)
Gedeon Richter
Design and optimization of renin inhibitors: Orally bioavailable alkyl amines.
Bioorg Med Chem Lett 19: 3541-5 (2009)
Vitae Pharmaceuticals
Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking.
Bioorg Med Chem Lett 19: 3756-9 (2009)
H. Lee Moffitt Cancer Center
Identification of 2-aminobenzimidazoles as potent melanin-concentrating hormone 1-receptor (MCH1R) antagonists.
Bioorg Med Chem Lett 19: 3568-72 (2009)
Banyu Pharmaceutical
Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition.
Bioorg Med Chem Lett 19: 3525-30 (2009)
Incyte
Non-isotopic dual parameter competition assay suitable for high-throughput screening of histone deacetylases.
Bioorg Med Chem Lett 19: 3651-6 (2009)
University Of G£Ttingen
Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents.
Eur J Med Chem 44: 3798-804 (2009)
Hamdard University
Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.
J Med Chem 52: 3869-80 (2009)
University Of Illinois At Urbana-Champaign
5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.
J Med Chem 52: 3855-68 (2009)
F. Hoffmann-La Roche
Design, synthesis and primary activity evaluation of L-arginine derivatives as amino-peptidase N/CD13 inhibitors.
Bioorg Med Chem 17: 4666-73 (2009)
Shandong University
N-Substituted-2-alkyl- and 2-arylnorapomorphines: novel, highly active D2 agonists.
Bioorg Med Chem 17: 4756-62 (2009)
University Of Tartu
The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection: comparative studies with AMD3100.
Antimicrob Agents Chemother 53: 2940-8 (2009)
National Institute Of Infectious Diseases
Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase.
Bioorg Med Chem 17: 4773-85 (2009)
University Of Debrecen
Analysis of binding parameters of HIV-1 integrase inhibitors: correlates of drug inhibition and resistance.
Bioorg Med Chem 17: 4806-18 (2009)
University Of Cyprus
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.
Bioorg Med Chem 17: 4503-9 (2009)
Universite Degli Studi Di Firenze
Human sialidase inhibitors: design, synthesis, and biological evaluation of 4-acetamido-5-acylamido-2-fluoro benzoic acids.
Bioorg Med Chem 17: 4595-603 (2009)
Gifu University
Discovery and structure-guided drug design of inhibitors of 11beta-hydroxysteroid-dehydrogenase type I based on a spiro-carboxamide scaffold.
Bioorg Med Chem Lett 19: 3682-5 (2009)
Merck Serono
A versatile photoactivatable probe designed to label the diphosphate binding site of farnesyl diphosphate utilizing enzymes.
Bioorg Med Chem 17: 4797-805 (2009)
University Of Minnesota
The discovery of the potent aurora inhibitor MK-0457 (VX-680).
Bioorg Med Chem Lett 19: 3586-92 (2009)
Vertex Pharmaceuticals
Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors.
Bioorg Med Chem Lett 19: 3615-8 (2009)
Universit£
In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates.
Bioorg Med Chem Lett 19: 3661-3 (2009)
Atat£Rk University
Preparation of L-proline based aeruginosin 298-A analogs: optimization of the P1-moiety.
Bioorg Med Chem Lett 19: 3798-803 (2009)
University Of New Orleans
Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening.
Bioorg Med Chem Lett 19: 3598-601 (2009)
Semmelweis University
Serratezomines D and E, new Lycopodium alkaloids from Lycopodium serratum var. serratum.
Bioorg Med Chem Lett 19: 3577-80 (2009)
Hokkaido University
Nocathiacin analogs: Synthesis and antibacterial activity of novel water-soluble amides.
Bioorg Med Chem Lett 19: 3531-5 (2009)
Merck Research Laboratories
Optimization of 5-phenyl-3-pyridinecarbonitriles as PKCtheta inhibitors.
Bioorg Med Chem Lett 19: 3623-6 (2009)
Wyeth Research
Discovery of novel arylpyrazole series as potent and selective opioid receptor-like 1 (ORL1) antagonists.
Bioorg Med Chem Lett 19: 3627-31 (2009)
Banyu Pharmaceutical
Design, synthesis and pharmacological evaluation of new 1-[3-(4-arylpiperazin-1-yl)-2-hydroxy-propyl]-3,3-diphenylpyrrolidin-2-one derivatives with antiarrhythmic, antihypertensive, and alpha-adrenolytic activity.
Eur J Med Chem 44: 3994-4003 (2009)
Jagiellonian University Medical College
Quinazolindione derivatives as potent 5-HT3A receptor antagonists.
Bioorg Med Chem 17: 4793-6 (2009)
Konkuk University
Design and synthesis of 3-alkyl-2-aryl-1,3-thiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.
Bioorg Med Chem Lett 19: 3162-5 (2009)
Shahid Beheshti University (M.C)
Novel non-peptide beta-secretase inhibitors derived from structure-based virtual screening and bioassay.
Bioorg Med Chem Lett 19: 3188-92 (2009)
Singapore Polytechnic
Discovery of selective PDE4B inhibitors.
Bioorg Med Chem Lett 19: 3174-6 (2009)
Asahi Kasei Pharma
New potential AChE inhibitor candidates.
Eur J Med Chem 44: 3754-9 (2009)
Universidade Bras£Lia
Fluorinated isatin derivatives. Part 2. New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis.
J Med Chem 52: 3484-95 (2009)
Westfalische Wilhelms-Universitat
Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists.
J Med Chem 52: 3563-75 (2009)
National Institute On Drug Abuse-Intramural Research Program
Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors.
Bioorg Med Chem 17: 4708-17 (2009)
Wyeth Research
Glycogen phosphorylase inhibitory effects of 2-oxo-1,2-dihydropyridin-3-yl amide derivatives.
Bioorg Med Chem 17: 4724-33 (2009)
Griffith University
Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype.
Bioorg Med Chem Lett 19: 3209-13 (2009)
Vanderbilt University Medical Center
Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists.
Bioorg Med Chem Lett 19: 3183-7 (2009)
Chemical Diversity Research Institute
Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator.
Bioorg Med Chem Lett 19: 3275-8 (2009)
H. Lundbeck
A novel class of H3 antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin.
Bioorg Med Chem Lett 19: 3204-8 (2009)
Vanderbilt University
A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone.
Bioorg Med Chem 17: 3770-4 (2009)
Duquesne University Mylan School Of Pharmacy
The discovery of novel calcium sensing receptor negative allosteric modulators.
Bioorg Med Chem Lett 19: 3328-32 (2009)
Pfizer
Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties.
J Med Chem 52: 3453-6 (2009)
Irbm/Merck Research Laboratories
Discovery of N-{N-[(3-cyanophenyl)sulfonyl]-4(R)-cyclobutylamino-(L)-prolyl}-4-[(3',5'-dichloroisonicotinoyl) amino]-(L)-phenylalanine (MK-0668), an extremely potent and orally active antagonist of very late antigen-4.
J Med Chem 52: 3449-52 (2009)
Merck Research Laboratories
Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C.
J Med Chem 52: 3969-81 (2009)
University Of Helsinki
Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.
J Med Chem 52: 3445-8 (2009)
Vanderbilt University Medical Center
Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors.
J Med Chem 52: 3576-85 (2009)
Pfizer
Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273.
J Med Chem 52: 4063-7 (2009)
Istanbul University
Biological activity of endomorphin and [Dmt1]endomorphin analogs with six-membered proline surrogates in position 2.
Bioorg Med Chem 17: 3789-94 (2009)
Medical University Of Lodz
Pyridones as glucokinase activators: identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle.
Bioorg Med Chem Lett 19: 3247-52 (2009)
Pfizer
Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors.
Bioorg Med Chem Lett 19: 3170-3 (2009)
Istanbul University
1-[4-(N-Benzylamino)phenyl]-3-phenylurea derivatives as a new class of hypoxia-inducible factor-1alpha inhibitors.
Bioorg Med Chem Lett 19: 3166-9 (2009)
Gakushuin University
Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists.
J Med Chem 52: 3644-51 (2009)
Universita Di Pisa
Synthesis and in vitro activity of heterocyclic inhibitors of CYP2A6 and CYP2A13, two cytochrome P450 enzymes present in the respiratory tract.
Chembiochem 10: 1562-7 (2009)
University Of Basel
Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands.
Bioorg Med Chem Lett 19: 3214-6 (2009)
Wyeth Research
Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors.
Bioorg Med Chem Lett 19: 3344-7 (2009)
The Scripps Research Institute
Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain.
Bioorg Med Chem Lett 19: 3199-203 (2009)
Schering-Plough Research Institute
Design, synthesis and biological evaluation of novel substituted benzoylguanidine derivatives as potent Na+/H+ exchanger inhibitors.
Bioorg Med Chem Lett 19: 3283-7 (2009)
China Pharmaceutical University
Novel orally bioavailable gamma-secretase inhibitors with excellent in vivo activity.
J Med Chem 52: 3441-4 (2009)
Merck Sharp & Dohme Research Laboratories
Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.
J Med Chem 52: 3597-617 (2009)
Gtx
New insight into the binding mode of peptide ligands at Urotensin-II receptor: structure-activity relationships study on P5U and urantide.
J Med Chem 52: 3927-40 (2009)
University Of Naples Federico Ii
In vivo effects of a GPR30 antagonist.
Nat Chem Biol 5: 421-7 (2009)
University Of New Mexico Health Sciences Center
Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity.
Bioorg Med Chem Lett 19: 3253-8 (2009)
Pfizer
Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids.
Bioorg Med Chem Lett 19: 3233-7 (2009)
Mcmaster University
Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.
Bioorg Med Chem Lett 19: 3664-8 (2009)
Gsk
Discovery of potential new InhA direct inhibitors based on pharmacophore and 3D-QSAR analysis followed by in silico screening.
Eur J Med Chem 44: 3718-30 (2009)
China Pharmaceutical University
Structure-activity relationships of 3,5-disubstituted benzamides as glucokinase activators with potent in vivo efficacy.
Bioorg Med Chem 17: 3800-9 (2009)
Banyu Tsukuba Research Institute
Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor.
Bioorg Med Chem 17: 3923-33 (2009)
Wayne State University
The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives.
Bioorg Med Chem Lett 19: 3271-4 (2009)
Vanderbilt University School Of Medicine
Synthesis and biological evaluation of penem inhibitors of bacterial signal peptidase.
Bioorg Med Chem Lett 19: 3787-90 (2009)
The Scripps Research Institute
Synthetic staurosporines via a ring closing metathesis strategy as potent JAK3 inhibitors and modulators of allergic responses.
Bioorg Med Chem Lett 19: 3333-8 (2009)
Johnson & Johnson Pharmaceutical Research & Development
Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains.
Bioorg Med Chem Lett 19: 3305-9 (2009)
Max Planck Institute Of Biochemistry
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.
J Med Chem 52: 3548-62 (2009)
European Research Centre For Drug Discovery And Development (Natsyndrugs)
Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase.
Biochemistry 48: 5226-38 (2009)
Albert Einstein College Of Medicine
Synthesis and biological evaluation of 3,4,6-triaryl-2-pyranones as a potential new class of anti-breast cancer agents.
Bioorg Med Chem 17: 3847-56 (2009)
Central Drug Research Institute
Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors.
Bioorg Med Chem 17: 3810-7 (2009)
Shandong University
Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations.
Bioorg Med Chem Lett 19: 3783-6 (2009)
Duke University
A new series of 3-phenylcoumarins as potent and selective MAO-B inhibitors.
Bioorg Med Chem Lett 19: 3268-70 (2009)
Facultad De Farmacia
Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).
Bioorg Med Chem Lett 19: 3238-42 (2009)
Merck Research Laboratories
Novel carbamate cholinesterase inhibitors that release biologically active amines following enzyme inhibition.
Bioorg Med Chem Lett 19: 3243-6 (2009)
Sention
Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives.
Bioorg Med Chem Lett 19: 3324-7 (2009)
Guiyang Medical College
Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13.
J Med Chem 52: 3523-38 (2009)
Novartis
Pyrrolidinoindoline alkaloids from Selaginella moellendorfii.
J Nat Prod 72: 1151-4 (2009)
Chinese Academy Of Sciences
A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase.
Bioorg Med Chem 17: 3916-22 (2009)
Boston College
Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives.
Bioorg Med Chem Lett 19: 3002-5 (2009)
Ghent University
Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1).
Bioorg Med Chem Lett 19: 2924-7 (2009)
Bristol-Myers Squibb Pharmaceutical Research And Development
Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.
Bioorg Med Chem Lett 19: 3023-6 (2009)
University Of Illinois At Chicago
Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.
Bioorg Med Chem Lett 19: 3014-8 (2009)
University Of Alberta
Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity.
J Med Chem 52: 3093-7 (2009)
Ewha Womans University
Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors.
J Med Chem 52: 2909-22 (2009)
Nagoya City University
Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling.
J Med Chem 52: 2762-75 (2009)
University Of Bonn
Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virus helicase.
J Med Chem 52: 2716-23 (2009)
National Taiwan University
Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity.
J Med Chem 52: 2673-82 (2009)
University Of St. Andrews
Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.
J Med Chem 52: 3377-84 (2009)
Abbott Laboratories
Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies.
Bioorg Med Chem 17: 3987-94 (2009)
Vu University Amsterdam
Cyclobutane-containing peptides: evaluation as novel metallocarboxypeptidase inhibitors and modelling of their mode of action.
Bioorg Med Chem 17: 3824-8 (2009)
Universitat AutòNoma De Barcelona
6,7-Dihydro-5H-pyrrolo[1,2-a] imidazoles as potent and selective alpha1A adrenoceptor partial agonists.
Bioorg Med Chem Lett 19: 3113-7 (2009)
Pfizer
Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase.
Bioorg Med Chem Lett 19: 3031-5 (2009)
Alma Mater Studiorum-Bologna University
Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase.
Bioorg Med Chem Lett 19: 3019-22 (2009)
Vertex Pharmaceuticals
Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid.
Bioorg Med Chem Lett 19: 2920-3 (2009)
Osaka Prefecture University
Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches.
ACS Chem Biol 4: 473-83 (2009)
Pfizer
Molecular and conformational determinants of pituitary adenylate cyclase-activating polypeptide (PACAP) for activation of the PAC1 receptor.
J Med Chem 52: 3308-16 (2009)
Institut National De La Recherche Scientifique
Design, microwave-assisted synthesis and HIV-RT inhibitory activity of 2-(2,6-dihalophenyl)-3-(4,6-dimethyl-5-(un)substituted-pyrimidin-2-yl)thiazolidin-4-ones.
Bioorg Med Chem 17: 3980-6 (2009)
Hebei University
Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-alpha converting enzyme (TACE) inhibitors.
Bioorg Med Chem 17: 3857-65 (2009)
Wyeth Research
Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064.
Bioorg Med Chem Lett 19: 2969-73 (2009)
Glaxosmithkline
Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.
Bioorg Med Chem Lett 19: 3081-4 (2009)
Irbm/Merck Research Laboratories
Structure-activity relationship studies of small-molecule inhibitors of Wnt response.
Bioorg Med Chem Lett 19: 3825-7 (2009)
The University Of Texas Southwestern Medical Center At Dallas
Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening.
Bioorg Med Chem Lett 19: 2965-8 (2009)
Merck
The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter.
Bioorg Med Chem Lett 19: 2974-6 (2009)
Pfizer
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.
Eur J Med Chem 44: 3712-7 (2009)
Universit£
Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores.
Bioorg Med Chem 17: 3934-58 (2009)
Biocryst Pharmaceuticals
Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1.
Bioorg Med Chem Lett 19: 2977-80 (2009)
Merck Research Laboratories
SAR studies for a new class of antibacterial NAD biosynthesis inhibitors.
J Comb Chem 11: 617-25 (2009)
University Of Alabama At Birmingham
Conformational analysis of N,N-disubstituted-1,4-diazepane orexin receptor antagonists and implications for receptor binding.
Bioorg Med Chem Lett 19: 2997-3001 (2009)
Merck Research Laboratories
Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.
Bioorg Med Chem Lett 19: 3674-8 (2009)
Gsk
Predictive models of Cannabinoid-1 receptor antagonists derived from diverse classes.
Bioorg Med Chem Lett 19: 2990-6 (2009)
Korea Research Institute Of Chemical Technology
Potent cytotoxic C-11 modified geldanamycin analogues.
J Med Chem 52: 3265-73 (2009)
Kosan Biosciences
Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii.
J Nat Prod 72: 805-12 (2009)
Saic-Frederick
Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists.
Bioorg Med Chem Lett 19: 3072-7 (2009)
Tsukuba Research Institute
Synthesis and biological characterization of B-ring amino analogues of potent benzothiadiazine hepatitis C virus polymerase inhibitors.
J Med Chem 52: 3174-83 (2009)
Abbott Laboratories
Rhodamine inhibitors of P-glycoprotein: an amide/thioamide"switch" for ATPase activity.
J Med Chem 52: 3328-41 (2009)
The State University Of New York
Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats.
J Med Chem 52: 3348-53 (2009)
University Of Kuopio
A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.
J Med Chem 52: 3300-7 (2009)
Genentech
New 1alpha,25-dihydroxy-19-norvitamin D(3) compounds constrained in a single A-ring conformation: synthesis of the analogues by ring-closing metathesis route and their biological evaluation.
J Med Chem 52: 3496-504 (2009)
University Of Wisconsin-Madison
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
Antimicrob Agents Chemother 53: 2777-84 (2009)
Gilead Sciences
1,3-dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships.
Bioorg Med Chem 17: 3618-29 (2009)
Universidade De Santiago De Compostela
Chloro-oxime derivatives as novel small molecule chaperone amplifiers.
Bioorg Med Chem Lett 19: 3128-35 (2009)
Cytrx
Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists.
Bioorg Med Chem 17: 3557-67 (2009)
Seoul National University
Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.
Bioorg Med Chem 17: 3659-64 (2009)
Universit£
Optimization of benzimidazole series as opioid receptor-like 1 (ORL1) antagonists: SAR study directed toward improvement of selectivity over hERG activity.
Bioorg Med Chem Lett 19: 3100-3 (2009)
Banyu Pharmaceutical
Aryl sulfonamido tetralin inhibitors of the Kv1.5 ion channel.
Bioorg Med Chem Lett 19: 3063-6 (2009)
Icagen
Synthesis and biological activities of topoisomerase I inhibitors, 6-arylmethylamino analogues of edotecarin.
J Med Chem 52: 3225-37 (2009)
Tsukuba Research Institute
Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells.
J Med Chem 52: 3191-204 (2009)
National Cancer Institute-Bethesda
Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain.
J Med Chem 52: 3366-76 (2009)
Abbott Laboratories
Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1).
J Med Chem 52: 3259-64 (2009)
Monash University (Parkville Campus)
Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease.
J Med Chem 52: 3146-9 (2009)
Peking University
A new screening assay for allosteric inhibitors of cSrc.
Nat Chem Biol 5: 394-6 (2009)
Chemical Genomics Centre Of The Max Planck Society
Impact of linker strain and flexibility in the design of a fragment-based inhibitor.
Nat Chem Biol 5: 407-13 (2009)
Johns Hopkins University
Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
Bioorg Med Chem Lett 19: 2674-8 (2009)
Merck Serono
Discovery of 5-substituted 2-amino-4-chloro-8-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7,8-dihydropteridin-6(5H)-ones as potent and selective Hsp90 inhibitors.
Bioorg Med Chem Lett 19: 2860-4 (2009)
Poniard Pharmaceuticals
Computer-aided rational molecular design of argifin-derivatives with increased inhibitory activity against chitinase B from Serratia marcescens.
Bioorg Med Chem Lett 19: 2630-3 (2009)
Kitasato University
Synthesis of spirocyclic sigma1 receptor ligands as potential PET radiotracers, structure-affinity relationships and in vitro metabolic stability.
Bioorg Med Chem 17: 3630-41 (2009)
Institut FüR Pharmazeutische Und Medizinische Chemie Der UniversitäT MüNster
Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRbeta.
Bioorg Med Chem 17: 3519-27 (2009)
Wyeth Research
Inhibition of Pseudomonas aeruginosa quorum sensing by AI-2 analogs.
Bioorg Med Chem Lett 19: 3941-4 (2009)
Ben-Gurion University Of The Negev
3-(aminomethyl)piperazine-2,5-dione as a novel NMDA glycine site inhibitor from the chemical universe database GDB.
Bioorg Med Chem Lett 19: 3832-5 (2009)
University Of Berne
Steroidal bivalent ligands for the estrogen receptor: design, synthesis, characterization and binding affinities.
Bioorg Med Chem 17: 3528-35 (2009)
University Of Illinois At Urbana-Champaign
2,4(5)-diarylimidazoles as inhibitors of hNaV1.2 sodium channels: pharmacological evaluation and structure-property relationships.
Bioorg Med Chem 17: 3642-8 (2009)
Università
On the inhibition of HIV-1 protease by hydrazino-ureas displaying the N-->C=O interaction.
Bioorg Med Chem 17: 3671-9 (2009)
Universit£
Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase.
Bioorg Med Chem Lett 19: 3136-40 (2009)
Glaxosmithkline
Application of combinatorial biocatalysis for a unique ring expansion of dihydroxymethylzearalenone.
Bioorg Med Chem Lett 19: 3059-62 (2009)
Amri
Potent and selective alpha1A adrenoceptor partial agonists--novel imidazole frameworks.
Bioorg Med Chem Lett 19: 3118-21 (2009)
Pfizer
Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors.
Bioorg Med Chem Lett 19: 3050-3 (2009)
Cv Therapeutics
2-Cyclohexylcarbonylbenzimidazoles as potent, orally available and brain-penetrable opioid receptor-like 1 (ORL1) antagonists.
Bioorg Med Chem Lett 19: 3096-9 (2009)
Banyu Pharmaceutical
Phenethyl pyridines with non-polar internal substituents as selective ligands for estrogen receptor beta.
Eur J Med Chem 44: 3560-70 (2009)
University Of Illinois
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
Chem Biol 16: 411-20 (2009)
Pfizer
Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin.
J Nat Prod 72: 725-31 (2009)
University Of California
Discovery process and pharmacological characterization of 2-(S)-(4-fluoro-2-methylphenyl)piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethylphenyl)ethyl]methylamide (vestipitant) as a potent, selective, and orally active NK1 receptor antagonist.
J Med Chem 52: 3238-47 (2009)
Glaxosmithkline
Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.
J Med Chem 52: 7528-36 (2009)
Johnson & Johnson Pharmaceutical Research & Development
Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.
J Med Chem 52: 3142-5 (2009)
Tsukuba Research Institute
Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part I.
Bioorg Med Chem Lett 19: 2624-6 (2009)
Biocryst Pharmaceuticals
Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part II.
Bioorg Med Chem Lett 19: 2627-9 (2009)
Biocryst Pharmaceuticals
A new type of five-membered heterocyclic inhibitors of basic metallocarboxypeptidases.
Eur J Med Chem 44: 3266-71 (2009)
Universitat Aut£Noma De Barcelona
2009 Edward E Smissman Award. Pharmaceutical"gold" from neurostabilizing agents: topiramate and successor molecules.
J Med Chem 52: 3431-40 (2009)
Johnson & Johnson Pharmaceutical Research & Development
Large-scale application of high-throughput molecular mechanics with Poisson-Boltzmann surface area for routine physics-based scoring of protein-ligand complexes.
J Med Chem 52: 3159-65 (2009)
Abbott Laboratories
Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties.
J Med Chem 52: 2989-3000 (2009)
Novo Nordisk
Rapid identification of improved protein ligands using peptoid microarrays.
Bioorg Med Chem Lett 19: 3866-9 (2009)
University Of Texas Southwestern Medical Center
Conformationally constrained analogues of diacylglycerol (DAG). 31. Modulation of the biological properties of diacylgycerol lactones (DAG-lactones) containing rigid-rod acyl groups separated from the core lactone by spacer units of different lengths.
J Med Chem 52: 3274-83 (2009)
National Cancer Institute-Frederick
An innovative method to study target protein-drug interactions by mass spectrometry.
J Med Chem 52: 2875-9 (2009)
Martin-Luther-UniversitäT Halle-Wittenberg
Chalcones: a valid scaffold for monoamine oxidases inhibitors.
J Med Chem 52: 2818-24 (2009)
Sapienza University Of Rome
Synthesis and SAR of amino acid-derived heterocyclic progesterone receptor full and partial agonists.
Bioorg Med Chem Lett 19: 2637-41 (2009)
Glaxosmithkline
4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations.
Bioorg Med Chem Lett 19: 2683-7 (2009)
Umr Gicc
Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase.
Bioorg Med Chem Lett 19: 2646-9 (2009)
Bristol-Myers Squibb Research And Development
Aryloxypyrazines as highly selective antagonists of Oxytocin.
Bioorg Med Chem Lett 19: 2634-6 (2009)
Pfizer
Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists.
Bioorg Med Chem 17: 3733-8 (2009)
Ewha Womans University
Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE.
Bioorg Med Chem Lett 19: 2654-60 (2009)
Bristol-Myers Squibb Research And Development
Triazinediones as prokineticin 1 receptor antagonists. Part 1: SAR, synthesis and biological evaluation.
Bioorg Med Chem Lett 19: 2661-3 (2009)
Johnson & Johnson Pharmaceutical Research And Development
Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Bioorg Med Chem Lett 19: 2642-5 (2009)
Universit£
Synthesis and evaluation of structurally constrained imidazolidin derivatives as potent dipeptidyl peptidase IV inhibitors.
Eur J Med Chem 44: 3318-22 (2009)
Sichuan University
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.
J Med Chem 52: 2724-32 (2009)
Csic
Sequence-derived three-dimensional pharmacophore models for G-protein-coupled receptors and their application in virtual screening.
J Med Chem 52: 2923-32 (2009)
Sanofi-Aventis Deutschland
Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
J Med Chem 52: 3047-62 (2009)
Kalypsys
Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry.
J Med Chem 52: 2940-51 (2009)
Wayne State University School Of Medicine
Compounds binding to the S2-S3 pockets of thrombin.
J Med Chem 52: 2708-15 (2009)
University Of Kalmar
Discovery of 4-azaindoles as novel inhibitors of c-Met kinase.
Bioorg Med Chem Lett 19: 2780-4 (2009)
Ucb Pharma
Identification and structure-activity relationships of chromene-derived selective estrogen receptor modulators for treatment of postmenopausal symptoms.
J Med Chem 52: 7544-69 (2009)
Johnson & Johnson Pharmaceutical Research & Development
Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5.
J Med Chem 52: 3063-72 (2009)
Astellas Pharma
Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.
Antimicrob Agents Chemother 53: 2824-33 (2009)
Monash University (Parkville Campus)
Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity.
Antimicrob Agents Chemother 53: 3065-73 (2009)
Oklahoma State University
Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).
Bioorg Med Chem 17: 3342-51 (2009)
Wyeth Research
Synthesis, cytotoxic activity, DNA topoisomerase-II inhibition, molecular modeling and structure-activity relationship of 9-anilinothiazolo[5,4-b]quinoline derivatives.
Bioorg Med Chem 17: 3266-77 (2009)
Universidad Nacional AutóNoma De MéXico
Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones.
Bioorg Med Chem Lett 19: 2714-7 (2009)
National Cancer Institute-Frederick
Design, synthesis, and characterization of 6beta-naltrexol analogs, and their selectivity for in vitro opioid receptor subtypes.
Bioorg Med Chem Lett 19: 2811-4 (2009)
University Of New England
Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors.
Bioorg Med Chem Lett 19: 2742-6 (2009)
Methylgene
Preparation of two sets of 5,6,7-trioxygenated dihydroflavonol derivatives as free radical scavengers and neuronal cell protectors to oxidative damage.
Bioorg Med Chem 17: 3414-25 (2009)
Pharmacy School Of Wenzhou Medical College
Design and synthesis of a novel tyrosine kinase inhibitor template.
Bioorg Med Chem 17: 3308-16 (2009)
St. Jude Children'S Research Hospital
Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors.
Bioorg Med Chem 17: 3302-7 (2009)
University Of Gda£?Sk
Effects of new 5-amino-1,3,4-thiadiazole-2-sulfonamide derivatives on human carbonic anhydrase isozymes.
Bioorg Med Chem 17: 3295-301 (2009)
Dumlupinar University
Design and synthesis of novel hybrid benzamide-peptide histone deacetylase inhibitors.
Bioorg Med Chem Lett 19: 3928-31 (2009)
The Scripps Research Institute
Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum.
Bioorg Med Chem Lett 19: 2801-3 (2009)
Silla University
Antagonists of the human A(2A) receptor. Part 5: Highly bio-available pyrimidine-4-carboxamides.
Bioorg Med Chem Lett 19: 2664-7 (2009)
Vernalis (R+D)
SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes.
Bioorg Med Chem Lett 19: 2747-51 (2009)
Methylgene
Synthetic studies in butenonyl C-glycosides: Preparation of polyfunctional alkanonyl glycosides and their enzyme inhibitory activity.
Bioorg Med Chem Lett 19: 2699-703 (2009)
Central Drug Research Institute
Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators.
Bioorg Med Chem Lett 19: 2718-21 (2009)
Banyu Tsukuba Research Institute
Identification of pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf kinase inhibitors.
Bioorg Med Chem Lett 19: 2735-8 (2009)
Wyeth Research
Synthesis, in vitro and computational studies of protein tyrosine phosphatase 1B inhibition of a small library of 2-arylsulfonylaminobenzothiazoles with antihyperglycemic activity.
Bioorg Med Chem 17: 3332-41 (2009)
Universidad AutóNoma Del Estado De Morelos
Design and synthesis of novel delta opioid receptor agonists and their pharmacologies.
Bioorg Med Chem Lett 19: 2792-5 (2009)
Kitasato University
New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors.
Bioorg Med Chem Lett 19: 2722-7 (2009)
Kyoto Pharmaceutical University
Substrate based peptide aldehyde inhibits bacterial type I signal peptidase.
Bioorg Med Chem Lett 19: 2880-3 (2009)
Katholieke Universiteit Leuven
Synthesis and structure-activity relationships of phenothiazine carboxylic acids having pyrimidine-dione as novel histamine H(1) antagonists.
Bioorg Med Chem Lett 19: 2766-71 (2009)
Dainippon Sumitomo Phrama.
Low molecular weight non-peptide mimics of omega-conotoxin GVIA.
Bioorg Med Chem Lett 19: 2763-5 (2009)
Csiro Molecular And Health Technologies
Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity.
Bioorg Med Chem Lett 19: 2693-8 (2009)
Chinese Academy Of Sciences
Synthesis and evaluation of novel phenoxypropanolamine derivatives containing acetanilides as potent and selective beta3-adrenergic receptor agonists.
Bioorg Med Chem 17: 3283-94 (2009)
Astellas Pharma
Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors.
Bioorg Med Chem Lett 19: 2891-5 (2009)
Vertex Pharmaceuticals
Surface plasmon resonance-based detection of ladder-shaped polyethers by inhibition detection method.
Bioorg Med Chem Lett 19: 2824-8 (2009)
Osaka University
Identification and characterization of a selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R).
Bioorg Med Chem Lett 19: 2835-9 (2009)
Tsukuba Research Institute
Recent developments in the design and synthesis of hybrid molecules based on aminoquinoline ring and their antiplasmodial evaluation.
Eur J Med Chem 44: 3091-113 (2009)
Universidad Industrial De Santander
8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists.
J Med Chem 52: 3073-83 (2009)
Bristol-Myers Squibb
Synthesis and structure-activity relationships of 8-(pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: potent, orally bioavailable corticotropin releasing factor receptor-1 (CRF1) antagonists.
J Med Chem 52: 3084-92 (2009)
Bristol-Myers Squibb
Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes.
J Med Chem 52: 3001-9 (2009)
Universita Del Piemonte Orientale
Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study.
J Med Chem 52: 2933-9 (2009)
Ku Leuven
Discovery and exploitation of inhibitor-resistant aurora and polo kinase mutants for the analysis of mitotic networks.
J Biol Chem 284: 15880-93 (2009)
University Of Manchester
Structure-activity relationship studies of a novel series of anthrax lethal factor inhibitors.
Bioorg Med Chem 17: 3352-68 (2009)
Institute For Medical Research
Synthesis and evaluation of aryl-substituted diarylpropionitriles, selective ligands for estrogen receptor beta, as positron-emission tomographic imaging agents.
Bioorg Med Chem 17: 3479-88 (2009)
Institute Of Radiological And Medical Sciences
4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: design, synthesis and structure-activity relationships.
Bioorg Med Chem Lett 19: 2829-34 (2009)
Pfizer
Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors.
Bioorg Med Chem Lett 19: 2840-3 (2009)
Sigma-Tau Research And Development
Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase.
Bioorg Med Chem Lett 19: 2804-7 (2009)
Novartis Institutes For Biomedical Research
Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities.
Eur J Med Chem 44: 3195-200 (2009)
Universiti Putra Malaysia
Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors.
J Med Chem 52: 3689-702 (2009)
Actelion Pharmaceuticals
Halogen bonding--a novel interaction for rational drug design?
J Med Chem 52: 2854-62 (2009)
Chinese Academy Of Sciences
Discovery and characterization of the N-phenyl-N'-naphthylurea class of p38 kinase inhibitors.
Bioorg Med Chem Lett 19: 2386-91 (2009)
Boehringer Ingelheim Pharmaceuticals
Biphenyl C-cyclopropylalkylamides: New scaffolds for targeting estrogen receptor beta.
Bioorg Med Chem Lett 19: 2404-8 (2009)
University Of Pittsburgh
Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.
J Med Chem 52: 3108-11 (2009)
Institutet
Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists.
J Med Chem 52: 3039-46 (2009)
Merck Research Laboratories
Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase.
J Med Chem 52: 2846-53 (2009)
Vanderbilt University
Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst1) selective analogues.
J Med Chem 52: 2733-46 (2009)
The Clayton Foundation Laboratories For Peptide Biology
N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation.
J Med Chem 52: 2794-8 (2009)
Bristol-Myers Squibb
Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.
J Med Chem 52: 2683-93 (2009)
University Of Leeds
Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity.
J Med Chem 52: 2652-5 (2009)
Pfizer
Susceptibility of highly pathogenic H5N1 influenza viruses to the neuraminidase inhibitor oseltamivir differs in vitro and in a mouse model.
Antimicrob Agents Chemother 53: 3088-96 (2009)
St. Jude Children'S Research Hospital
High-throughput screening identifies novel inhibitors of the acetyltransferase activity of Escherichia coli GlmU.
Antimicrob Agents Chemother 53: 2306-11 (2009)
Mcmaster University
Combinatorial chemistry in the agrosciences.
Bioorg Med Chem 17: 4035-46 (2009)
Bayer Cropscience
4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors.
Bioorg Med Chem Lett 19: 2504-8 (2009)
Glaxosmithkline
Synthesis of a new opioid ligand having the oxabicyclo[3.2.1]octane skeleton using a new rearrangement reaction.
Bioorg Med Chem Lett 19: 2416-9 (2009)
Kitasato University
Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.
Bioorg Med Chem Lett 19: 2468-73 (2009)
F. Hoffmann-La Roche
Synthesis and evaluation of some novel isochroman carboxylic acid derivatives as potential anti-diabetic agents.
Eur J Med Chem 44: 3147-57 (2009)
Glenmark Research Center
Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics.
J Med Chem 52: 2880-98 (2009)
Metabasis Therapeutics
Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047).
J Med Chem 52: 3028-38 (2009)
Proteolix
Cucurbitane-type triterpenoids from the stems of Cucumis melo.
J Nat Prod 72: 824-9 (2010)
Chinese Academy Of Sciences
Discovery of 6-aryl-7-alkoxyisoquinoline inhibitors of IkappaB kinase-beta (IKK-beta).
J Med Chem 52: 3098-102 (2009)
Gsk
Synthesis of novel 1-alkyl-8-substituted-3-(3-methoxypropyl) xanthines as putative A(2B) receptor antagonists.
Bioorg Med Chem 17: 3426-32 (2009)
Universidade De A Coru£A
Synthesis and SAR of tolylamine 5-HT6 antagonists.
Bioorg Med Chem Lett 19: 2409-12 (2009)
Pfizer
Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists.
Bioorg Med Chem Lett 19: 2400-3 (2009)
Pfizer
1-Sulfonylindazoles as potent and selective 5-HT6 ligands.
Bioorg Med Chem Lett 19: 2413-5 (2009)
Wyeth Research
Synthesis of potent antitumor and antiviral benzofuran derivatives.
Bioorg Med Chem Lett 19: 2420-8 (2009)
National Research Centre
Synthesis and PKCtheta inhibitory activity of a series of 4-indolylamino-5-phenyl-3-pyridinecarbonitriles.
Bioorg Med Chem Lett 19: 2461-3 (2009)
Wyeth Research
Significance of interactions of BACE1-Arg235 with its ligands and design of BACE1 inhibitors with P2 pyridine scaffold.
Bioorg Med Chem Lett 19: 2435-9 (2009)
Kyoto Pharmaceutical University
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases.
J Med Chem 52: 2776-85 (2009)
Universita Degli Studi Del Piemonte Orientale A. Avogadro
Inhibition of monoamine oxidase by (E)-styrylisatin analogues.
Bioorg Med Chem Lett 19: 2509-13 (2009)
North-West University
Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones.
J Med Chem 52: 2694-707 (2009)
University College London
Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part II).
Bioorg Med Chem 17: 3061-71 (2009)
Shandong University
Synthesis of dammarane-type triterpene derivatives and their ability to inhibit HIV and HCV proteases.
Bioorg Med Chem 17: 3003-10 (2009)
University Of Toyama
Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).
Bioorg Med Chem Lett 19: 2514-8 (2009)
Merck Research Laboratories
The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents.
Bioorg Med Chem Lett 19: 2537-41 (2009)
Pfizer
Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform.
Bioorg Med Chem Lett 19: 2456-60 (2009)
Johnson & Johnson Pharmaceutical Research & Development
Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarials.
Bioorg Med Chem Lett 19: 2570-3 (2009)
Central Drug Research Institute
The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety.
Bioorg Med Chem Lett 19: 2519-23 (2009)
Schering-Plough Research Institute
Synthesis and evaluation of dibenzothiazepines: a novel class of selective cannabinoid-1 receptor inverse agonists.
J Med Chem 52: 1975-82 (2009)
Acadia Pharmaceuticals
From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
J Med Chem 52: 1853-63 (2009)
University Of Illinois At Chicago
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.
J Med Chem 52: 3116-20 (2009)
Kochi Medical School
Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K.
J Med Chem 52: 2786-93 (2009)
Virginia Tech
Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo.
Psychopharmacology (Berl) 205: 119-28 (2009)
Case Western Reserve University
Design, synthesis, and biological evaluation of new 5-HT4 receptor agonists: application as amyloid cascade modulators and potential therapeutic utility in Alzheimer's disease.
J Med Chem 52: 2214-25 (2009)
Cnrs
Conformationally constrained peptidomimetic inhibitors of signal transducer and activator of transcription. 3: Evaluation and molecular modeling.
J Med Chem 52: 2429-42 (2009)
The University Of Texas M.D. Anderson Cancer Center
Topoisomerase I gene mutations at F270 in the large subunit and N184 in the small subunit contribute to the resistance mechanism of the unicellular parasite Leishmania donovani towards 3,3'-diindolylmethane.
Antimicrob Agents Chemother 53: 2589-98 (2009)
India Institute Of Chemical Biology
Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety.
Bioorg Med Chem Lett 19: 2482-6 (2009)
Schering-Plough Research Institute
Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (GSK269984A) an EP(1) receptor antagonist for the treatment of inflammatory pain.
Bioorg Med Chem Lett 19: 2599-603 (2009)
Glaxosmithkline
Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.
J Med Chem 52: 2372-83 (2009)
Institute
Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin.
J Med Chem 52: 2177-80 (2009)
Trinity College
New resorcinol-anandamide"hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo.
J Med Chem 52: 2506-14 (2009)
Universita Degli Studi Di Siena
N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists.
J Med Chem 52: 2559-70 (2009)
National Institute On Drug Abuse-Intramural Research Program
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
J Nat Prod 72: 830-4 (2010)
China Medical University
Ligand-directed tosyl chemistry for protein labeling in vivo.
Nat Chem Biol 5: 341-3 (2009)
Kyoto University
Botulinum neurotoxin serotype A inhibitors: small-molecule mercaptoacetamide analogs.
Bioorg Med Chem 17: 3072-9 (2009)
Absolute Science
Schiff bases of 3-formylchromone as thymidine phosphorylase inhibitors.
Bioorg Med Chem 17: 2983-8 (2009)
University Of Karachi
Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.
Bioorg Med Chem 17: 2989-3002 (2009)
Institute Of Nuclear Chemistry Johannes Gutenberg-University Mainz
Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part I).
Bioorg Med Chem 17: 3053-60 (2009)
Shandong University
Diether derivatives of homo- or substituted piperidines as non-imidazole histamine H3 receptor ligands.
Bioorg Med Chem 17: 3037-42 (2009)
Jagiellonian University Medical College
Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2.
Bioorg Med Chem Lett 19: 2500-3 (2009)
Infinity Pharmaceuticals
3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.
Bioorg Med Chem Lett 19: 2464-7 (2009)
Wyeth Research
Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors.
Bioorg Med Chem Lett 19: 2487-91 (2009)
Wyeth Research
3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization.
Bioorg Med Chem Lett 19: 2524-9 (2009)
Pfizer
(+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners.
Bioorg Med Chem Lett 19: 2530-2 (2009)
The City University Of New York
Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist.
Bioorg Med Chem Lett 19: 2595-8 (2009)
Roche R & D Center(China)
Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation.
Bioorg Med Chem Lett 19: 2591-4 (2009)
Merck Research Laboratories
Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a CB1 receptor antagonist with in vivo antiobesity effect.
Bioorg Med Chem Lett 19: 2546-50 (2009)
Zydus Research Centre
Expedient solid-phase synthesis of both symmetric and asymmetric diol libraries targeting aspartic proteases.
Bioorg Med Chem Lett 19: 3945-8 (2009)
National University Of Singapore
Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
Bioorg Med Chem 17: 3177-88 (2009)
Peking University
Synthesis and structure-activity relationship of novel diarylpyrazole imide analogues as CB1 cannabinoid receptor ligands.
Bioorg Med Chem 17: 3080-92 (2009)
Green Cross
Synthesis and SAR of 4-substituted-2-aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.
Bioorg Med Chem Lett 19: 2099-102 (2009)
Pfizer
1-(5-Carboxyindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: synthesis and properties of bioisosteric benzimidazole, benzotriazole and indazole analogues.
Bioorg Med Chem Lett 19: 2107-11 (2009)
University Of M£Nster
Multivariate QSAR study of 4,5-dihydroxypyrimidine carboxamides as HIV-1 integrase inhibitors.
Eur J Med Chem 44: 3577-83 (2009)
Universidade Estadual Do Oeste Do Paran£
Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.
J Med Chem 52: 2188-91 (2009)
Washington University
Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity.
J Med Chem 52: 2384-92 (2009)
Universidad Complutense De Madrid
Synthesis and herbicidal activities of novel 4-(4-(5-methyl-3-arylisoxazol-4-yl)thiazol-2-yl)piperidyl carboxamides and thiocarboxamides.
Molecules 14: 1288-303 (2009)
Central China Normal University
Modulations of the amide function of the preferential dopamine D3 agonist (R,R)-S32504: improvements of affinity and selectivity for D3 versus D2 receptors.
Bioorg Med Chem Lett 19: 2133-8 (2009)
Institut De Recherches Servier
NMR strategy for unraveling structures of bioactive sponge-derived oxy-polyhalogenated diphenyl ethers.
J Nat Prod 72: 443-9 (2009)
University Of California
2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.
J Med Chem 52: 2571-86 (2009)
Abbott Laboratories
Harnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease.
J Med Chem 52: 2163-76 (2009)
Purdue University
Pyridoimidazolones as novel potent inhibitors of v-Raf murine sarcoma viral oncogene homologue B1 (BRAF).
J Med Chem 52: 2255-64 (2009)
The Institute Of Cancer Research
Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase.
J Med Chem 52: 2443-53 (2009)
Washington University
Fluorine and rhenium substituted ghrelin analogues as potential imaging probes for the growth hormone secretagogue receptor.
J Med Chem 52: 2196-203 (2009)
University Of Western Ontario
L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives.
J Med Chem 52: 2352-62 (2009)
Universita Degli Studi Di Bologna
Structure-based virtual screening of Src kinase inhibitors.
Bioorg Med Chem 17: 3152-61 (2009)
Konkuk University
Synthesis and structure-activity relationships of amide derivatives of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetic acid as selective arginine vasopressin V2 receptor agonists.
Bioorg Med Chem 17: 3130-41 (2009)
Astellas Pharma
Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators.
Bioorg Med Chem Lett 19: 2139-43 (2009)
Bristol-Myers Squibb
Knowledge based identification of MAO-B selective inhibitors using pharmacophore and structure based virtual screening models.
Eur J Med Chem 44: 3584-90 (2009)
Gvk Biosciences
Discovery and development of aurora kinase inhibitors as anticancer agents.
J Med Chem 52: 2629-51 (2009)
Vertex Pharmaceuticals
1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity.
J Med Chem 52: 2550-8 (2009)
Merck Research Laboratories
A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy.
J Med Chem 52: 2531-42 (2009)
University Of Dundee
Optimisation of a series of potent, selective and orally bioavailable GlyT1 inhibitors.
Bioorg Med Chem Lett 19: 2235-9 (2009)
Merck Sharp And Dohme Research Laboratories
Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4.
J Med Chem 52: 2289-310 (2009)
Wyeth Research
Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.
J Med Chem 52: 2185-7 (2009)
Harvard Medical School
N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice.
J Med Chem 52: 2393-406 (2009)
University Of Camerino
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.
J Med Chem 52: 2226-32 (2009)
Kochi Medical School
Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists.
J Med Chem 52: 2493-505 (2009)
Glaxosmithkline
N(G)-acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent.
J Med Chem 52: 2623-7 (2009)
University Of Regensburg
Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating arylsulfonamide groups.
J Med Chem 52: 2280-8 (2009)
Glaxosmithkline
Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3.
J Med Chem 52: 2204-13 (2009)
Bioxell
Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.
J Med Chem 52: 2587-602 (2009)
Merck Research Laboratories
Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J Med Chem 52: 2465-81 (2009)
Shanghai Institute Of Materia Medica
Pyranonaphthoquinone lactones: a new class of AKT selective kinase inhibitors alkylate a regulatory loop cysteine.
J Med Chem 52: 2181-4 (2009)
Wyeth Research
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
J Med Chem 52: 3829-45 (2009)
St. Jude Children'S Research Hospital
GPR109a agonists. Part 1: 5-Alkyl and 5-aryl-pyrazole-tetrazoles as agonists of the human orphan G-protein coupled receptor GPR109a.
Bioorg Med Chem Lett 19: 2121-4 (2009)
Merck Research Laboratories
Discovery of potent and selective DP1 receptor antagonists in the azaindole series.
Bioorg Med Chem Lett 19: 2125-8 (2009)
Merck Frosst Centre For Therapeutic Research
A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties.
Bioorg Med Chem Lett 19: 2206-10 (2009)
Boehringer Ingelheim Pharmaceuticals
Molecular docking and ligand specificity in fragment-based inhibitor discovery.
Nat Chem Biol 5: 358-64 (2009)
University Of California San Francisco
Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita.
Bioorg Med Chem 17: 2689-94 (2009)
Seoul National University
1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3.
Bioorg Med Chem Lett 19: 2230-4 (2009)
Glaxosmithkline
The identification of novel PLC-gamma inhibitors using virtual high throughput screening.
Bioorg Med Chem 17: 3169-76 (2009)
The Institute Of Cancer Research
5,6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents.
Bioorg Med Chem Lett 19: 2158-61 (2009)
Central Drug Research Institute
Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis.
Bioorg Med Chem Lett 19: 2129-32 (2009)
Anacor Pharmaceuticals
Discovery of potent non-urea inhibitors of soluble epoxide hydrolase.
Bioorg Med Chem Lett 19: 2354-9 (2009)
Columbia University
Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.
J Med Chem 52: 2265-79 (2009)
University Of Regensburg
Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands.
J Med Chem 52: 2311-6 (2009)
University Of Turin
Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists.
J Med Chem 52: 2618-22 (2009)
National Health Research Institutes
Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
J Med Chem 52: 2407-19 (2009)
Universita Di Firenze
Role of the hydrogen bonding heteroatom-Lys53 interaction between the p38alpha mitogen-activated protein (MAP) kinase and pyridinyl-substituted 5-membered heterocyclic ring inhibitors.
J Med Chem 52: 2613-7 (2009)
Islamic University Of Gaza
Antimalarials from nature.
Bioorg Med Chem 17: 3229-56 (2009)
National Institute Of Pharmaceutical Education And Research
Fluorinated isatin derivatives. Part 1: synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors.
Bioorg Med Chem 17: 2680-8 (2009)
WestfäLische Wilhelms-UniversitäT
Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors.
Bioorg Med Chem 17: 2775-84 (2009)
Shandong University
Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity.
Bioorg Med Chem Lett 19: 2240-3 (2009)
Vanderbilt University
Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy.
Bioorg Med Chem Lett 19: 2252-7 (2009)
Vu University Amsterdam
Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors.
Bioorg Med Chem 17: 2658-72 (2009)
University Of Modena And R.E.
Argifin; efficient solid phase total synthesis and evaluation of analogues of acyclic peptide.
Bioorg Med Chem 17: 2751-8 (2009)
Kitasato University
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with aliphatic and aromatic carboxylates.
Bioorg Med Chem 17: 2654-7 (2009)
Università
Anthranilamide-based N,N-dialkylbenzamidines as potent and orally bioavailable factor Xa inhibitors: P4 SAR.
Bioorg Med Chem Lett 19: 2186-9 (2009)
Millennium Pharmaceuticals
Exploring the PI3K alpha and gamma binding sites with 2,6-disubstituted isonicotinic derivatives.
Bioorg Med Chem Lett 19: 2215-9 (2009)
University Of Cincinnati
Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor.
Bioorg Med Chem Lett 19: 2179-85 (2009)
Millennium Pharmaceuticals
Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors.
J Med Chem 52: 1670-80 (2009)
University Of Alberta
Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
J Med Chem 52: 1525-9 (2009)
University Of Alberta
Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.
J Med Chem 52: 2060-6 (2009)
University Of California Irvine
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.
J Med Chem 52: 1864-72 (2009)
University Of Washington At Seattle
Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors.
J Med Chem 52: 2157-60 (2009)
University Of Messina
Substituted terphenyl compounds as the first class of low molecular weight allosteric inhibitors of the luteinizing hormone receptor.
J Med Chem 52: 2036-42 (2009)
Leiden University
N(epsilon)-thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors.
J Med Chem 52: 2153-6 (2009)
University Of Kuopio
Novel approach for chemotype hopping based on annotated databases of chemically feasible fragments and a prospective case study: new melanin concentrating hormone antagonists.
J Med Chem 52: 2076-89 (2009)
Johnson & Johnson Pharmaceutical R&D
Comparison of N-terminal modifications on neurotensin(8-13) analogues correlates peptide stability but not binding affinity with in vivo efficacy.
J Med Chem 52: 1803-13 (2009)
Medical University Of South Carolina
Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis.
Antimicrob Agents Chemother 53: 2052-8 (2009)
Genzyme
Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus.
Antimicrob Agents Chemother 53: 2289-97 (2009)
Universit£
Antiviral activity of MK-4965, a novel nonnucleoside reverse transcriptase inhibitor.
Antimicrob Agents Chemother 53: 2424-31 (2009)
Merck Research Laboratories
In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists.
Bioorg Med Chem Lett 19: 2190-4 (2009)
Medical Research Council Technology
Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors.
Bioorg Med Chem Lett 19: 2333-7 (2009)
Johnson & Johnson Pharmaceutical Research & Development
Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production.
Bioorg Med Chem Lett 19: 2176-8 (2009)
Pfizer
Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib.
Bioorg Med Chem Lett 19: 2270-2 (2009)
Chinese Academy Of Medical Sciences
Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.
Bioorg Med Chem Lett 19: 2273-6 (2009)
Griffith University
8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors--part II.
Bioorg Med Chem Lett 19: 2338-42 (2009)
Glaxosmithkline
Fluorinated non-imidazole histamine H3 receptor antagonists.
Bioorg Med Chem Lett 19: 2172-5 (2009)
Johann Wolfgang Goethe-UniversitäT
Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta.
Eur J Med Chem 44: 3412-24 (2009)
University Of Illinois
IKKbeta inhibitors identification part I: homology model assisted structure based virtual screening.
Bioorg Med Chem 17: 2759-66 (2009)
Institute Of Science And Technology
Piperidinyl-2-phenethylamino inhibitors of DPP-IV for the treatment of type 2 diabetes.
Bioorg Med Chem Lett 19: 2220-3 (2009)
Pfizer
Regioisomerism-dependent TLR7 agonism and antagonism in an imidazoquinoline.
Bioorg Med Chem Lett 19: 2211-4 (2009)
University Of Kansas
Characteristic of neuraminidase inhibitory xanthones from Cudrania tricuspidata.
Bioorg Med Chem 17: 2744-50 (2009)
Graduate School Of Gyeongsang National University
N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors.
Bioorg Med Chem Lett 19: 2346-9 (2009)
R&D Sigma-Tau
Discovery of 5-pyrrolopyridinyl-2-thiophenecarboxamides as potent AKT kinase inhibitors.
Bioorg Med Chem Lett 19: 2244-8 (2009)
Glaxosmithkline
Design of novel quinazoline derivatives and related analogues as potent and selective ALK5 inhibitors.
Bioorg Med Chem Lett 19: 2277-81 (2009)
Glaxosmithkline
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable"back-up" compound for N-tert-butyl isoquine.
J Med Chem 52: 1828-44 (2009)
University Of Liverpool
Novel 2- and 4-substituted 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric modulators of the A3 adenosine receptor.
J Med Chem 52: 2098-108 (2009)
National Institute Of Diabetes And Digestive And Kidney Diseases
Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action.
J Med Chem 52: 1885-902 (2009)
University Of Illinois At Chicago
Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors.
Bioorg Med Chem 17: 2712-7 (2009)
Institute For Medical Research
Discovery of potent and orally active 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as novel allosteric glucokinase activators.
Bioorg Med Chem 17: 2733-43 (2009)
Banyu Tsukuba Research Institute
8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.
Bioorg Med Chem 17: 2812-22 (2009)
University Of Camerino
Syntheses of novel high affinity ligands for opioid receptors.
Bioorg Med Chem Lett 19: 2289-94 (2009)
Rensselaer Polytechnic Institute
QSAR analysis of pyrazolidine-3,5-diones derivatives as Dyrk1A inhibitors.
Bioorg Med Chem Lett 19: 2324-8 (2009)
Inje University
Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists.
Bioorg Med Chem Lett 19: 2315-9 (2009)
Praecis Pharmaceuticals
Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1.
Bioorg Med Chem Lett 19: 2329-32 (2009)
Pfizer
Synthesis of protein tyrosine phosphatase 1B inhibitors: model validation and docking studies.
Bioorg Med Chem Lett 19: 2320-3 (2009)
Central Drug Research Institute
Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants.
Bioorg Med Chem Lett 19: 2299-304 (2009)
4Sc
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
J Med Chem 52: 1922-34 (2009)
Sapienza Universita Di Roma
Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists.
Bioorg Med Chem 17: 2842-51 (2009)
University Of Bonn
A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): discovery of (S)-2-(8-(methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408).
J Med Chem 52: 1799-802 (2009)
Wyeth Research
(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.
Bioorg Med Chem Lett 19: 1991-5 (2009)
Pfizer
Selective, potent PPARgamma agonists with cyclopentenone core structure.
Bioorg Med Chem Lett 19: 1883-6 (2009)
Universidade De Vigo
Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg.
Antimicrob Agents Chemother 53: 1944-51 (2009)
Centre National De R£F£Rence Des Salmonella
Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa.
Antimicrob Agents Chemother 53: 2274-82 (2009)
University Of Manitoba
Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors.
Bioorg Med Chem Lett 19: 1866-70 (2009)
Methylgene
Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation.
Bioorg Med Chem Lett 19: 1935-8 (2009)
Bristol-Myers Squibb Pharmaceutical Research Institute
Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase.
J Med Chem 52: 1943-52 (2009)
Burnham Institute For Medical Research
Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R).
J Med Chem 52: 2148-52 (2009)
Wyeth Research
Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
J Nat Prod 72: 626-31 (2009)
Heinrich-Heine-Universitat
Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and type 2 cholecystokinin receptors.
J Med Chem 52: 2138-47 (2009)
Mayo Clinic
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
Nat Chem Biol 5: 251-7 (2009)
Albert Einstein College Of Medicine
Reduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis.
J Biol Chem 284: 12874-85 (2009)
United States Army Medical Research Institute Of Infectious Diseases
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions.
Bioorg Med Chem Lett 19: 1855-7 (2009)
Universit£
Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett 19: 1908-12 (2009)
National Health Research Institutes
Oxadiazole-diarylpyrazole 4-carboxamides as cannabinoid CB1 receptor ligands.
Bioorg Med Chem Lett 19: 1899-902 (2009)
Green Cross
Amide-containing diketoacids as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity.
Bioorg Med Chem 17: 2913-9 (2009)
Shandong University
Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of the Staphylococcus aureus sortase SrtA isoform.
Bioorg Med Chem 17: 2886-93 (2009)
M.V. Lomonosov Moscow State University
Syntheses of novel 2,3-diaryl-substituted 5-cyano-4-azaindoles exhibiting c-Met inhibition activity.
Bioorg Med Chem Lett 19: 1879-82 (2009)
Technical University Of Darmstadt
7-Sulfonamido-3-benzazepines as potent and selective 5-HT2C receptor agonists: hit-to-lead optimization.
Bioorg Med Chem Lett 19: 1871-5 (2009)
Pfizer
Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation.
Bioorg Med Chem Lett 19: 1921-5 (2009)
University Of Warsaw
3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates--a new class of HIV-1 integrase inhibitors.
Bioorg Med Chem Lett 19: 1930-4 (2009)
Merck Research Laboratories Rome
Structure-based virtual screening approach to identify novel classes of PTP1B inhibitors.
Eur J Med Chem 44: 3280-4 (2009)
Sejong University
Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.
Bioorg Med Chem 17: 2371-80 (2009)
Northwestern University
Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring.
Bioorg Med Chem 17: 2461-75 (2009)
Queen'S University
Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2).
Bioorg Med Chem Lett 19: 2053-8 (2009)
Merck Research Laboratories
Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity.
Bioorg Med Chem Lett 19: 1916-20 (2009)
Vanderbilt University Medical Center
5-Benzylidene-hydantoins: synthesis and antiproliferative activity on A549 lung cancer cell line.
Eur J Med Chem 44: 3471-9 (2009)
Universit£
Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.
J Med Chem 52: 1935-42 (2009)
Sapienza University Of Rome
Novel tricyclic inhibitors of IkappaB kinase.
J Med Chem 52: 1994-2005 (2009)
Bristol-Myers Squibb
Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities.
J Med Chem 52: 1873-84 (2009)
Purdue University
Liver X receptor agonists with selectivity for LXRbeta; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides.
Bioorg Med Chem Lett 19: 2009-12 (2009)
Astrazeneca R&D SöDertäLje
Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38.
J Biol Chem 284: 12853-61 (2009)
The Scripps Research Institute
Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem 17: 2388-99 (2009)
National Health Research Institutes
Anthranilic acid based CCK1 receptor antagonists: blocking the receptor with the same 'words' of the endogenous ligand.
Bioorg Med Chem 17: 2336-50 (2009)
University Of Trieste
Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines.
Bioorg Med Chem 17: 2607-22 (2009)
Université
Synthesis of hydroxypyrone- and hydroxythiopyrone-based matrix metalloproteinase inhibitors: developing a structure-activity relationship.
Bioorg Med Chem Lett 19: 1970-6 (2009)
University Of California
Docking model of drug binding to the human ether-à-go-go potassium channel guided by tandem dimer mutant patch-clamp data: a synergic approach.
J Med Chem 52: 1630-8 (2009)
Takeda Pharmaceutical
Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily.
J Med Chem 52: 1251-4 (2009)
Bristol-Myers Squibb
Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.
J Med Chem 52: 1648-58 (2009)
Toronto General Research Institute
Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC.
Biochemistry 48: 3068-77 (2009)
Duke University
Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.
J Med Chem 52: 1510-3 (2009)
Vernalis (R&D)
Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor.
J Med Chem 52: 1522-4 (2009)
Celgene
Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor.
J Med Chem 52: 1558-68 (2009)
Astrazeneca
Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode.
J Med Chem 52: 1814-27 (2009)
Boehringer Ingelheim Pharmaceuticals
Dual inhibitors of phosphodiesterase-4 and serotonin reuptake.
J Med Chem 52: 1530-9 (2009)
Human Biomolecular Research Institute
Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors.
Bioorg Med Chem 17: 2476-82 (2009)
Universidade De S£O Paulo
Synthesis of new camptothecin analogs with improved antitumor activities.
Bioorg Med Chem Lett 19: 2018-21 (2009)
Chugai Pharmaceutical
Pharmacophore modeling study based on known spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors.
Bioorg Med Chem Lett 19: 1944-9 (2009)
Sichuan University
14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity.
J Med Chem 52: 1553-7 (2009)
University Of Bath
Aza-analogue dibenzepinone scaffolds as p38 mitogen-activated protein kinase inhibitors: design, synthesis, and biological data of inhibitors with improved physicochemical properties.
J Med Chem 52: 1778-82 (2009)
Eberhard-Karls-UniversitäT
Mixed kappa/mu opioid receptor agonists: the 6 beta-naltrexamines.
J Med Chem 52: 1546-52 (2009)
University Of Bath
Inhibition of Wnt signaling by Dishevelled PDZ peptides.
Nat Chem Biol 5: 217-9 (2009)
Genentech
Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor: structure-activity relationships of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template.
Bioorg Med Chem Lett 19: 1986-90 (2009)
Wyeth Research
Synthesis and biological evaluation of a small molecule library of 3rd generation multidrug resistance modulators.
Bioorg Med Chem 17: 2524-35 (2009)
University Of Bonn
Quantitative structure-activity relationship (QSAR) for a series of novel cannabinoid derivatives using descriptors derived from semi-empirical quantum-chemical calculations.
Bioorg Med Chem 17: 2598-606 (2009)
St. Jude Children'S Research Hospital
Incorporation of neutral C-terminal residues in 3-amidinophenylalanine-derived matriptase inhibitors.
Bioorg Med Chem Lett 19: 1960-5 (2009)
The Medicines Company (Leipzig)
Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
Bioorg Med Chem Lett 19: 2006-8 (2009)
The Institute For Diabetes Discovery
Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones.
Bioorg Med Chem Lett 19: 1982-5 (2009)
Institute Of Research
Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation.
Bioorg Med Chem Lett 19: 2075-8 (2009)
Pfizer
Homology modeling of MCH1 receptor and validation by docking/scoring and protein-aligned CoMFA.
Eur J Med Chem 44: 2583-96 (2009)
University Of Jordan
Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs).
Bioorg Med Chem Lett 19: 2001-5 (2009)
University Of Alabama At Birmingham
Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors.
Bioorg Med Chem Lett 19: 2048-52 (2009)
Cv Therapeutics
Development of CoMFA and CoMSIA models of affinity and selectivity for indole ligands of cannabinoid CB1 and CB2 receptors.
Eur J Med Chem 44: 2482-96 (2009)
Universidade Federal Do Rio De Janeiro
Biochemical basis for differences in metabolism-dependent genotoxicity by two diazinylpiperazine-based 5-HT2C receptor agonists.
Bioorg Med Chem Lett 19: 1559-63 (2009)
Pfizer
5-Aminomethylbenzimidazoles as potent ITK antagonists.
Bioorg Med Chem Lett 19: 1588-91 (2009)
Boehringer Ingelheim Pharmaceuticals
Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo.
Chem Biol 16: 193-202 (2009)
Johns Hopkins School Of Medicine
Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase.
Chem Biol 16: 181-92 (2009)
Duke University Medical Center
New poly(ADP-ribose) polymerase-1 inhibitors with antioxidant activity based on 4-carboxamidobenzimidazole-2-ylpyrroline and -tetrahydropyridine nitroxides and their precursors.
J Med Chem 52: 1619-29 (2009)
University Of Pecs
Synthesis and pharmacological characterization of beta2-adrenergic agonist enantiomers: zilpaterol.
J Med Chem 52: 1773-7 (2009)
Intervet Innovation
(-)-Dibromophakellin: an alpha2B adrenoceptor agonist isolated from the Australian marine sponge, Acanthella costata.
Bioorg Med Chem 17: 2497-500 (2009)
Griffith University
Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
Bioorg Med Chem 17: 2452-60 (2009)
University Of Chile
M3 muscarinic acetylcholine receptor antagonists: SAR and optimization of bi-aryl amines.
Bioorg Med Chem Lett 19: 1686-90 (2009)
Glaxosmithkline
Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors.
Bioorg Med Chem Lett 19: 1575-80 (2009)
Japan Tobacco
Morpholine containing CB2 selective agonists.
Bioorg Med Chem Lett 19: 1604-9 (2009)
Boehringer Ingelheim Pharmaceuticals
Potent inhibitors of Huntingtin protein aggregation in a cell-based assay.
Bioorg Med Chem Lett 19: 1715-7 (2009)
Columbia University
Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors.
Bioorg Med Chem Lett 19: 1733-6 (2009)
University Of Michigan At Ann Arbor
Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists.
Bioorg Med Chem Lett 19: 1564-8 (2009)
Tsukuba Research Institute
Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinesterase/butyrylcholinesterase.
Eur J Med Chem 44: 2523-32 (2009)
Sun Yat-Sen University
Development of the renal glucose reabsorption inhibitors: a new mechanism for the pharmacotherapy of diabetes mellitus type 2.
J Med Chem 52: 1785-94 (2009)
Bristol-Myers Squibb
Dancing of the second aromatic residue around the 6,8-diazabicyclo[3.2.2]nonane framework: influence on sigma receptor affinity and cytotoxicity.
J Med Chem 52: 2126-37 (2009)
Institut Fur Pharmazeutische Und Medizinische Chemie Der Westfalischen Wilhelms-Universitat Munster
Octahydrophenanthrene-2,7-diol analogues as dissociated glucocorticoid receptor agonists: discovery and lead exploration.
J Med Chem 52: 1731-43 (2009)
Pfizer
Rational modification of a candidate cancer drug for use against Chagas disease.
J Med Chem 52: 1639-47 (2009)
University Of Washington
Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands.
J Med Chem 52: 1540-5 (2009)
Acadia Pharmaceuticals
Kinase domain mutations in cancer: implications for small molecule drug design strategies.
J Med Chem 52: 1493-509 (2009)
Wyeth Research
Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities.
Antimicrob Agents Chemother 53: 2176-80 (2009)
Hershey Medical Center
Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding.
Bioorg Med Chem Lett 19: 1694-7 (2009)
Gsk
Benzimidazolone-based serotonin 5-HT1A or 5-HT7R ligands: synthesis and biological evaluation.
Bioorg Med Chem Lett 19: 1600-3 (2009)
Cnrs
Design, synthesis, and structure-activity relationship of novel CCR2 antagonists.
Bioorg Med Chem Lett 19: 1830-4 (2009)
Merck Research Laboratories
New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3.
Eur J Med Chem 44: 2563-71 (2009)
University Of Ljubljana
Synthesis and applications of polyamine amino acid residues: improving the bioactivity of an analgesic neuropeptide, neurotensin.
J Med Chem 52: 1514-7 (2009)
University Of Utah
Design, synthesis, and biological evaluation of (2R,alphaS)-3,4-dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-alpha-(trifluoromethyl)-1(2H)-quinolineethanol as potent and orally active cholesteryl ester transfer protein inhibitor.
J Med Chem 52: 1768-72 (2009)
Johnson And Johnson Pharmaceutical Research And Development
[2-(4-Phenyl-4-piperidinyl)ethyl]amine based CCR5 antagonists: derivatizations at the N-terminal of the piperidine ring.
Bioorg Med Chem Lett 19: 1610-3 (2009)
Glaxosmithkline
Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers.
Bioorg Med Chem Lett 19: 1666-9 (2009)
F. Hoffmann-La Roche
Discovery of substituted 2,4,4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists.
Bioorg Med Chem Lett 19: 1670-4 (2009)
Tsukuba Research Institute
Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study.
Bioorg Med Chem Lett 19: 1650-3 (2009)
University Of Medicine And Pharmacy At Ho Chi Minh City
Synthesis and biological evaluation of platensimycin analogs.
Bioorg Med Chem Lett 19: 1623-7 (2009)
Merck Research Laboratories
Aryl diketoacids (ADK) selectively inhibit duplex DNA-unwinding activity of SARS coronavirus NTPase/helicase.
Bioorg Med Chem Lett 19: 1636-8 (2009)
Konkuk University
The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors.
Eur J Med Chem 44: 2994-3008 (2009)
University Of Kuopio
Discovery of novel acetanilide derivatives as potent and selective beta3-adrenergic receptor agonists.
Eur J Med Chem 44: 2533-43 (2009)
Astellas Pharma
Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors.
Bioorg Med Chem Lett 19: 1682-5 (2009)
Abbott Laboratories
Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus.
J Med Chem 52: 1518-21 (2009)
Kosan Biosciences
Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols.
Bioorg Med Chem 17: 3207-11 (2009)
Ataturk University
Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action.
Bioorg Med Chem 17: 2501-11 (2009)
Pfizer
Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites.
Bioorg Med Chem 17: 2483-9 (2009)
Universidade De SãO Paulo
2,4-Diaminopyridine delta-opioid receptor agonists and their associated hERG pharmacology.
Bioorg Med Chem Lett 19: 1702-6 (2009)
Pfizer
5-Aminopyrimidin-2-ylnitriles as cathepsin K inhibitors.
Bioorg Med Chem Lett 19: 1658-61 (2009)
Astrazeneca
Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain.
Bioorg Med Chem Lett 19: 1628-31 (2009)
Roche Palo Alto
Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain.
Bioorg Med Chem Lett 19: 1632-5 (2009)
Roche Palo Alto
Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator.
Bioorg Med Chem Lett 19: 1654-7 (2009)
F. Hoffmann-La Roche
Synthesis, biological assays and QSAR studies of N-(9-benzyl-2-phenyl-8-azapurin-6-yl)-amides as ligands for A1 adenosine receptors.
Bioorg Med Chem 17: 1817-30 (2009)
Università
4,4-Difluorinated analogues of l-arginine and N(G)-hydroxy-l-arginine as mechanistic probes for nitric oxide synthase.
Bioorg Med Chem Lett 19: 1758-62 (2009)
University Of Utrecht
Discovery of non-peptidergic MrgX1 and MrgX2 receptor agonists and exploration of an initial SAR using solid-phase synthesis.
Bioorg Med Chem Lett 19: 1729-32 (2009)
Acadia Pharmaceuticals
Design and synthesis of novel tri-aryl CB2 selective cannabinoid ligands.
Bioorg Med Chem Lett 19: 1691-3 (2009)
University Of Tennessee-Memphis
Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold.
J Med Chem 52: 1723-30 (2009)
Genentech
On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors.
Chembiochem 10: 838-43 (2009)
Antibiotics Laboratory
Identification of Shc Src homology 2 domain-binding peptoid-peptide hybrids.
J Med Chem 52: 1612-8 (2009)
National Cancer Institute-Frederick
Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors.
J Med Chem 52: 1681-92 (2009)
Universita Di Pisa
Novel inhibitor of Plasmodium histone deacetylase that cures P. berghei-infected mice.
Antimicrob Agents Chemother 53: 1727-34 (2009)
Georgetown University Medical Center
Novel fatty acid synthase (FAS) inhibitors: design, synthesis, biological evaluation, and molecular docking studies.
Bioorg Med Chem 17: 1898-904 (2009)
Institute Of Pharmacology And Toxicology
Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases.
Bioorg Med Chem 17: 1811-6 (2009)
Science University Of Tokyo
Synthesis and preliminary screening of novel indole-3-methanamines as 5-HT4 receptor ligands.
Eur J Med Chem 44: 2952-9 (2009)
Monash University
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.
J Med Chem 52: 1408-15 (2010)
University Of Liverpool
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
J Med Chem 52: 1284-94 (2009)
Westphalian Wilhelms-University
Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes.
Bioorg Med Chem 17: 1783-802 (2009)
Matrix Laboratories
Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-alpha production.
Bioorg Med Chem Lett 19: 1722-5 (2009)
Abbott Laboratories
The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore.
Bioorg Med Chem Lett 19: 1802-6 (2009)
Gsk
Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.
Bioorg Med Chem Lett 19: 1797-801 (2009)
Amgen
[18F]FEAC and [18F]FEDAC: Two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain.
Bioorg Med Chem Lett 19: 1707-10 (2009)
National Institute Of Radiological Sciences
Synthesis, binding affinity and SAR of new benzolactam derivatives as dopamine D3 receptor ligands.
Bioorg Med Chem Lett 19: 1773-8 (2009)
Universidad De Santiago De Compostela
5-Arylidene-2-phenylimino-4-thiazolidinones as PTP1B and LMW-PTP inhibitors.
Bioorg Med Chem 17: 1928-37 (2009)
University Of Messina
Synthesis and cytotoxic activity of new azepino[3',4':4,5]pyrrolo[2,1-a]isoquinolin-12-ones.
Bioorg Med Chem 17: 1849-56 (2009)
Universidad Nacional AutóNoma De MéXico
Atropisomeric small molecule Bcl-2 ligands: determination of bioactive conformation.
Bioorg Med Chem Lett 19: 1767-72 (2009)
Ucb Pharma
Synthesis and structure-activity relationships of novel benzofuran farnesyltransferase inhibitors.
Bioorg Med Chem Lett 19: 1753-7 (2009)
Chugai Pharmaceutical
Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases.
Bioorg Med Chem Lett 19: 1718-21 (2009)
Abbott Laboratories
N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors.
Bioorg Med Chem Lett 19: 1745-8 (2009)
Biovitrum
Synthesis and SAR study of novel pseudo-steroids as potent and selective progesterone receptor antagonists.
Bioorg Med Chem Lett 19: 3977-80 (2009)
Johnson And Johnson Pharmaceutical Research And Development
1,3,4-Oxadiazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 2: SAR of the C5 position.
Bioorg Med Chem Lett 19: 1807-10 (2009)
Gsk
14-O-Heterocyclic-substituted naltrexone derivatives as non-peptide mu opioid receptor selective antagonists: design, synthesis, and biological studies.
Bioorg Med Chem Lett 19: 1825-9 (2009)
Virginia Commonwealth University
Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier protein reductase.
Eur J Med Chem 44: 3009-19 (2009)
International Centre For Science And High Technology
Synthesis and evaluation of 18F-labeled 2-phenylbenzothiazoles as positron emission tomography imaging agents for amyloid plaques in Alzheimer's disease.
J Med Chem 52: 1428-37 (2009)
Katholieke Universiteit Leuven
Syntheses and antigestagenic activity of mifepristone derivatives.
J Med Chem 52: 1268-74 (2010)
University Of Graz
Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities.
Bioorg Med Chem Lett 19: 1784-9 (2009)
Department Of Entomology And University Of California Davis Cancer Center
Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles.
Eur J Med Chem 44: 2434-46 (2009)
Universidade De Vigo
Antioxidant and anticholinesterase activity evaluation of ent-kaurane diterpenoids from Sideritis arguta.
J Nat Prod 72: 500-2 (2010)
Istanbul University
A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution.
J Med Chem 52: 1450-8 (2010)
National Institutes Of Health
Discovery of novel Myc-Max heterodimer disruptors with a three-dimensional pharmacophore model.
J Med Chem 52: 1247-50 (2009)
University Of Pittsburgh
N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett 19: 1323-8 (2009)
Methylgene
N-substituted 2'-(aminoaryl)benzothiazoles as kinase inhibitors: hit identification and scaffold hopping.
Bioorg Med Chem Lett 19: 1349-56 (2009)
4Sc
Synthesis and biological evaluation of C-12 triazole and oxadiazole analogs of salvinorin A.
Bioorg Med Chem Lett 19: 1301-4 (2009)
Harvard Medical School
Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls.
Eur J Med Chem 44: 2765-75 (2009)
Saarland University
A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products.
J Nat Prod 72: 588-603 (2010)
University Of California Santa Cruz
New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C(8) Substitution in Structural Analogues of S-Adenosylmethionine (dagger).
J Med Chem 52: 1388-407 (2009)
Cornell University
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor.
J Med Chem 52: 1255-8 (2010)
Pfizer
Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors.
Bioorg Med Chem Lett 19: 1332-6 (2009)
Gsk
Discovery of novel non-peptidic beta-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor antagonists.
Bioorg Med Chem Lett 19: 1305-9 (2009)
Novartis Institutes For Biomedical Research
Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.
Bioorg Med Chem Lett 19: 1287-91 (2009)
Novartis Institutes For Biomedical Research
Slow-onset inhibition of the FabI enoyl reductase from francisella tularensis: residence time and in vivo activity.
ACS Chem Biol 4: 221-31 (2009)
Stony Brook University
Synthesis and biological evaluation of 3,6-disubstituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as a novel class of potential anti-tumor agents.
Eur J Med Chem 44: 2776-81 (2009)
National Organization For Drug Control And Research
Anthracene based compounds as new L-type Ca2+ channel blockers: design, synthesis, and full biological profile.
J Med Chem 52: 1259-62 (2010)
University Of Padova
Synthesis and in vitro and in vivo evaluation of 18F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter.
J Med Chem 52: 1358-69 (2009)
Washington University
Synthesis, biological evaluation, and docking studies of N-substituted acetamidines as selective inhibitors of inducible nitric oxide synthase.
J Med Chem 52: 1481-5 (2010)
Universita G. D'Annunzio
Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.
Bioorg Med Chem Lett 19: 1451-6 (2009)
Bristol-Myers Squibb Research And Development
BRACO19 analog dimers with improved inhibition of telomerase and hPot 1.
Bioorg Med Chem 17: 2030-7 (2009)
University Of North Carolina At Chapel Hill
2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors.
Bioorg Med Chem 17: 2047-68 (2009)
Human Biomolecular Research Institute
Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.
Bioorg Med Chem 17: 3212-5 (2009)
Istanbul University
4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production.
Bioorg Med Chem Lett 19: 1310-3 (2009)
Pfizer
(2-Aryl-5-methylimidazol-4-ylcarbonyl)guanidines and (2-aryl-5-methyloxazol-4-ylcarbonyl)guanidines as NHE-1 inhibitors.
Bioorg Med Chem Lett 19: 1329-31 (2009)
Korea Research Institute Of Chemical Technology
Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta.
Bioorg Med Chem 17: 2017-29 (2009)
Takeda Pharmaceutical
Inhibition of iNOS and COX-2 in human whole blood ex vivo and monocyte-macrophage J774 cells by a new group of aminothiopyrimidone derivatives.
Bioorg Med Chem 17: 1991-6 (2009)
University Of Catania
3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists.
Bioorg Med Chem Lett 19: 1434-7 (2009)
Schering-Plough Research Institute
Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit.
Eur J Med Chem 44: 2787-95 (2009)
F. Hoffmann-La Roche
Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition.
J Nat Prod 72: 503-6 (2010)
National Cancer Institute-Frederick
Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists.
J Med Chem 52: 1416-27 (2010)
Virginia Commonwealth University
Biomedical application of orexin/hypocretin receptor ligands in neuroscience.
J Med Chem 52: 891-903 (2009)
Actelion Pharmaceuticals
Directed discovery of agents targeting the Met tyrosine kinase domain by virtual screening.
J Med Chem 52: 943-51 (2009)
National Cancer Institute-Frederick
Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.
J Med Chem 52: 1275-83 (2010)
Sirtris Pharmaceuticals
Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.
J Med Chem 52: 1310-6 (2009)
University Of Utah
Crystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGT.
Chembiochem 10: 716-27 (2009)
Philipps-UniversitÄT Marburg
Development and biological evaluation of a novel aurora A kinase inhibitor.
Chembiochem 10: 464-78 (2009)
Parc De Recerca Biomedica De Barcelona
Relationships between the structure of 6-substituted 6,8-diazabicyclo[3.2.2]nonan-2-ones and their sigma receptor affinity and cytotoxic activity.
Bioorg Med Chem 17: 1445-55 (2009)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster
Fluoroalkyl alpha side chain containing 3,4-diamino-cyclobutenediones as potent and orally bioavailable CXCR2-CXCR1 dual antagonists.
Bioorg Med Chem Lett 19: 1431-3 (2009)
Schering-Plough Research Institute
Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB).
Bioorg Med Chem Lett 19: 1376-9 (2009)
University Of Ljubljana
Morpholine-based RGD-cyclopentapeptides as alphavbeta3/alphavbeta5 integrin ligands: role of configuration towards receptor binding affinity.
Bioorg Med Chem 17: 1542-9 (2009)
Università
The identification of nonpeptide neurotensin receptor partial agonists from the potent antagonist SR48692 using a calcium mobilization assay.
Bioorg Med Chem Lett 19: 1438-41 (2009)
Research Triangle Institute
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo.
Bioorg Med Chem Lett 19: 1366-70 (2009)
Novartis Institutes For Biomedical Research
Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors.
Bioorg Med Chem Lett 19: 1361-5 (2009)
Novartis
Synthesis and biological activity of anticoccidial agents: 2,3-diarylindoles.
Bioorg Med Chem Lett 19: 1517-21 (2009)
Scynexis
Quinolines as a novel structural class of potent and selective PDE4 inhibitors: optimisation for oral administration.
Bioorg Med Chem Lett 19: 1380-5 (2009)
Glaxosmithkline
2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists.
J Med Chem 52: 826-33 (2009)
University Of WüRzburg
Additivity in the analysis and design of HIV protease inhibitors.
J Med Chem 52: 737-54 (2009)
Umbi
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
J Med Chem 52: 646-54 (2009)
University Of Tampere
A new class of vitamin D analogues that induce structural rearrangement of the ligand-binding pocket of the receptor.
J Med Chem 52: 1438-49 (2010)
Showa Pharmaceutical University
Pyrido[2,3-d]pyrimidin-5-ones: A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors (dagger).
J Med Chem 52: 1081-99 (2009)
Johnson & Johnson Pharmaceutical
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: inhibitors of factor Xa and platelet aggregation.
J Med Chem 52: 1018-28 (2009)
University Of Bari
Antagonists of the P2X(7) receptor. From lead identification to drug development.
J Med Chem 52: 3123-41 (2009)
Astrazeneca
Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus.
J Med Chem 52: 976-88 (2009)
University Of Illinois At Urbana-Champaign
Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate.
J Med Chem 52: 1180-9 (2009)
Glaxosmithkline
Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
J Med Chem 52: 1115-25 (2009)
The Scripps Research Institute
New high-throughput screening assay to reveal similarities and differences in inhibitory sensitivities of multidrug ATP-binding cassette transporters.
Antimicrob Agents Chemother 53: 1516-27 (2009)
Wroclaw Medical University
Synthesis and pharmacological activities of some sesquiterpene quinones and hydroquinones.
Bioorg Med Chem 17: 1422-7 (2009)
UniversitäT Bayreuth
64Cu-AMD3100--a novel imaging agent for targeting chemokine receptor CXCR4.
Bioorg Med Chem 17: 1486-93 (2009)
National Institute Of Biomedical Imaging And Bioengineering
(1,2,3-Triazol-4-yl)benzenamines: synthesis and activity against VEGF receptors 1 and 2.
Bioorg Med Chem Lett 19: 1344-8 (2009)
Decode
3-Acrylamide-4-aryloxyindoles: synthesis, biological evaluation and metabolic stability of potent and selective EP3 receptor antagonists.
Bioorg Med Chem Lett 19: 1528-31 (2009)
Decode Chemistry
Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators.
Bioorg Med Chem Lett 19: 1357-60 (2009)
Banyu Tsukuba Research Institute
New and selective ryanodine receptor activators for insect control.
Bioorg Med Chem 17: 4127-33 (2009)
Fmc Stine Research Center
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.
Bioorg Med Chem Lett 19: 1371-5 (2009)
Universit£
The identification of orally bioavailable thrombopoietin agonists.
Bioorg Med Chem Lett 19: 1428-30 (2009)
Pfizer
Novel E. coli beta-ketoacyl-acyl carrier protein synthase III inhibitors as targeted antibiotics.
Bioorg Med Chem 17: 1506-13 (2009)
Konkuk University
1-Amido-1-phenyl-3-piperidinylbutanes--CCR5 antagonists for the treatment of HIV: part 2.
Bioorg Med Chem Lett 19: 1499-503 (2009)
Pfizer
Molecular hybridization, synthesis, and biological evaluation of novel chroman I(Kr) and I(Ks) dual blockers.
Bioorg Med Chem Lett 19: 1477-80 (2009)
China Pharmaceutical University
Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.
Bioorg Med Chem Lett 19: 1446-50 (2009)
Amgen
Novel pyrrolidine ureas as C-C chemokine receptor 1 (CCR1) antagonists.
J Med Chem 52: 1295-301 (2010)
Pharmacopeia
Synthesis and SAR studies of trisubstituted purinones as potent and selective adenosine A2A receptor antagonists.
Bioorg Med Chem Lett 19: 1399-402 (2009)
Pharmacopeia
Discovery of GlyT1 inhibitors with improved pharmacokinetic properties.
Bioorg Med Chem Lett 19: 1492-5 (2009)
Merck
N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.
Bioorg Med Chem Lett 19: 1403-8 (2009)
S*Bio
Studies on depigmenting activities of dihydroxyl benzamide derivatives containing adamantane moiety.
Bioorg Med Chem Lett 19: 1532-3 (2009)
Amorepacific
Design, synthesis, and biological evaluation of 1,5-benzothiazepine-4-one derivatives targeting factor VIIa/tissue factor.
Bioorg Med Chem Lett 19: 1386-91 (2009)
University Of Montpellier
Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1).
Bioorg Med Chem Lett 19: 1522-7 (2009)
TBA
Design, synthesis, and anti-HIV activity of 4'-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors.
Bioorg Med Chem 17: 1739-46 (2009)
Gilead Science
Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents.
Bioorg Med Chem 17: 1764-71 (2009)
Yale University
Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors.
Bioorg Med Chem Lett 19: 1512-6 (2009)
Universit£
Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors.
Bioorg Med Chem Lett 19: 1488-91 (2009)
Merck
Aminofurazans as potent inhibitors of AKT kinase.
Bioorg Med Chem Lett 19: 1508-11 (2009)
Glaxosmithkline
Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors.
J Med Chem 52: 1156-71 (2009)
Wyeth Research
Derivatives of 5-nitro-furan-2-carboxylic acid carbamoylmethyl ester inhibit RNase H activity associated with HIV-1 reverse transcriptase.
J Med Chem 52: 1380-7 (2010)
Chiba University
Novel Indazole Non-Nucleoside Reverse Transcriptase Inhibitors Using Molecular Hybridization Based on Crystallographic Overlays (dagger).
J Med Chem 52: 1219-23 (2009)
Pfizer
Examination of the biological role of the alpha(2-->6)-linked sialic acid in gangliosides binding to the myelin-associated glycoprotein (MAG).
J Med Chem 52: 989-1004 (2009)
University Of Basel
Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S(1)' Subsite of Matrix Metalloproteinase 8 (MMP-8) (dagger).
J Med Chem 52: 1040-9 (2009)
Universita Degli Studi
Morpholino, piperidino, and pyrrolidino derivatives of pyrimidine nucleosides as inhibitors of ribonuclease A: synthesis, biochemical, and crystallographic evaluation.
J Med Chem 52: 932-42 (2009)
Institute Of Technology
In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor.
Antimicrob Agents Chemother 53: 1377-85 (2009)
Tibotec
1-Amido-1-phenyl-3-piperidinylbutanes - CCR5 antagonists for the treatment of HIV. Part 1.
Bioorg Med Chem Lett 19: 1075-9 (2009)
Pfizer
Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline.
Bioorg Med Chem Lett 19: 1071-4 (2009)
University Of Michigan
Discovery of small molecule human C5a receptor antagonists.
Bioorg Med Chem Lett 19: 1143-7 (2009)
Astrazeneca
Computational studies of epidermal growth factor receptor: docking reliability, three-dimensional quantitative structure-activity relationship analysis, and virtual screening studies.
J Med Chem 52: 964-75 (2009)
Universit£
Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties.
Biochemistry 48: 1322-31 (2009)
University Of Florida
Thioamide Hydroxypyrothiones Supersede Amide Hydroxypyrothiones in Potency against Anthrax Lethal Factor.
J Med Chem 52: 1063-74 (2009)
Howard Hughes Medical Institute
Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase.
J Med Chem 52: 1126-43 (2009)
Industrial Research
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations.
J Med Chem 52: 1224-8 (2009)
Universita Di Siena
Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.
J Med Chem 52: 1190-7 (2009)
University Of Regensburg
Synthesis of new analogs of benzotriazole, benzimidazole and phthalimide--potential inhibitors of human protein kinase CK2.
Bioorg Med Chem 17: 1573-8 (2009)
Institute Of Biochemistry And Biophysics
5-Aryl-4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone.
Bioorg Med Chem Lett 19: 1089-92 (2009)
Fermentas
Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.
Bioorg Med Chem Lett 19: 1101-4 (2009)
Johnson & Johnson Pharmaceutical
Non-urea functionality as the primary pharmacophore in soluble epoxide hydrolase inhibitors.
Bioorg Med Chem Lett 19: 1066-70 (2009)
ArêTe Therapeutics
Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings.
Bioorg Med Chem Lett 19: 1105-9 (2009)
Schering-Plough Research Institute
Discovery of mu-opioid selective ligands derived from 1-aminotetralin scaffolds made via metal-catalyzed ring-opening reactions.
Bioorg Med Chem Lett 19: 1228-32 (2009)
University Of Toronto
Synthesis, pharmacological and in silico evaluation of 1-(4-di-hydroxy-3,5-dioxa-4-borabicyclo[4.4.0]deca-7,9,11-trien-9-yl)-2-(tert-butylamino)ethanol, a compound designed to act as a beta2 adrenoceptor agonist.
Eur J Med Chem 44: 2840-6 (2009)
Instituto Polit£Cnico Nacional (Ipn)
13-Methyl-substituted des-C,D analogs of (20S)-1alpha,25-dihydroxy-2-methylene-19-norvitamin D3 (2MD): synthesis and biological evaluation.
Bioorg Med Chem 17: 1747-63 (2009)
University Of Wisconsin-Madison
Novel 1,4-diarylpiperidine-4-methylureas as anti-hyperlipidemic agents: dual effectors on acyl-CoA:cholesterol O-acyltransferase and low-density lipoprotein receptor expression.
Bioorg Med Chem Lett 19: 1062-5 (2009)
Dainippon Sumitomo Pharma
5-Hydroxyindole-type alkaloids, as Candida albicans isocitrate lyase inhibitors, from the tropical sponge Hyrtios sp.
Bioorg Med Chem Lett 19: 1051-3 (2009)
Institute
Synthesis and SAR of potent LXR agonists containing an indole pharmacophore.
Bioorg Med Chem Lett 19: 1097-100 (2009)
Gsk
The design and discovery of novel amide CCR5 antagonists.
Bioorg Med Chem Lett 19: 1084-8 (2009)
Pfizer
Tricyclic HIV integrase inhibitors: VI. SAR studies of 'benzyl flipped' C3-substituted pyrroloquinolines.
Bioorg Med Chem Lett 19: 1187-90 (2009)
Gilead Sciences
Bis(hetero)aryl derivatives as unique kinesin spindle protein inhibitors.
Bioorg Med Chem Lett 19: 1058-61 (2009)
University Of Shizuoka
Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions.
Antimicrob Agents Chemother 53: 1528-31 (2009)
Cnrs-Cpbs/Umr 5236
Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase.
Bioorg Med Chem 17: 1600-13 (2009)
Chinese Academy Of Sciences
Biarylether amide quinolines as liver X receptor agonists.
Bioorg Med Chem 17: 1663-70 (2009)
Wyeth Research
Taste-guided identification of high potency TRPA1 agonists from Perilla frutescens.
Bioorg Med Chem 17: 1636-9 (2009)
Università
A Dimeric sesquiterpenoid from a Malaysian Meiogyne as a new inhibitor of Bcl-xL/BakBH3 domain peptide interaction.
J Nat Prod 72: 480-3 (2010)
Cnrs
Total synthesis of photoactivatable or fluorescent anandamide probes: novel bioactive compounds with angiogenic activity.
J Med Chem 52: 1005-17 (2009)
University Of Montpellier
A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor.
J Med Chem 52: 926-31 (2009)
Leiden University
Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1.
J Med Chem 52: 912-5 (2009)
University Of Copenhagen
Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR).
J Med Chem 52: 904-7 (2009)
Exelixis
Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.
J Med Chem 52: 675-87 (2009)
Universitat De Barcelona
Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists.
Bioorg Med Chem 17: 1640-7 (2009)
Università
Synthesis and cyclooxygenase inhibition of various (aryl-1,2,3-triazole-1-yl)-methanesulfonylphenyl derivatives.
Bioorg Med Chem 17: 1146-51 (2009)
University Of Alberta
Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups.
Bioorg Med Chem 17: 1716-23 (2009)
Florida A&M University
Development of thioquinazolinones, allosteric Chk1 kinase inhibitors.
Bioorg Med Chem Lett 19: 1240-4 (2009)
Merck Research Laboratories
Design, synthesis, and evaluation of oxygen-containing macrocyclic peptidomimetics as inhibitors of HCV NS3 protease.
J Med Chem 52: 700-8 (2009)
Schering-Plough Research Institute
Identification of a series of benzoxazoles as potent 5-HT6 ligands.
Bioorg Med Chem Lett 19: 1115-7 (2009)
Wyeth Research
Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters.
Bioorg Med Chem Lett 19: 1118-21 (2009)
Université
Aromatic organic compounds as scaffolds for metallocarboxypeptidase inhibitor design.
Chem Biol Drug Des 73: 75-82 (2009)
Universitat AutÒnoma De Barcelona
Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors.
Chem Biol Drug Des 73: 62-74 (2009)
University Of Connecticut
A small molecule that binds Hedgehog and blocks its signaling in human cells.
Nat Chem Biol 5: 154-6 (2009)
Broad Institute Of Harvard And Massachusetts Institute Of Technology
Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives.
Bioorg Med Chem 17: 1207-13 (2009)
Anhui University Of Technology
Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor.
Bioorg Med Chem 17: 1370-80 (2009)
Mclean Hospital
Synthesis of 18F-labelled 2-(4'-fluorophenyl)-1,3-benzothiazole and evaluation as amyloid imaging agent in comparison with [11C]PIB.
Bioorg Med Chem Lett 19: 602-5 (2009)
K.U.Leuven
Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: part 2.
Bioorg Med Chem Lett 19: 1164-7 (2009)
Schering-Plough Research Institute
Synthesis and pharmacological evaluation of aminopyrimidine series of 5-HT1A partial agonists.
Bioorg Med Chem Lett 19: 1159-63 (2009)
Pfizer
The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor.
J Med Chem 52: 818-25 (2009)
Glaxosmithkline
Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds.
J Biol Chem 284: 7646-55 (2009)
National Yang-Ming University
Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening.
Bioorg Med Chem Lett 19: 589-96 (2009)
University Of Manchester
Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.
Eur J Med Chem 44: 2877-87 (2009)
Christian-Albrechts-University Of Kiel
Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer.
J Med Chem 52: 514-23 (2009)
Abbott Laboratories
Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity.
J Med Chem 52: 389-96 (2009)
University Of Georgia
Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.
J Med Chem 52: 379-88 (2009)
Astex
Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow.
J Med Chem 52: 369-78 (2009)
University Of Innsbruck
Structural analysis of ARC-type inhibitor (ARC-1034) binding to protein kinase A catalytic subunit and rational design of bisubstrate analogue inhibitors of basophilic protein kinases.
J Med Chem 52: 308-21 (2009)
University Of Tartu
Discovery and Structure-Activity Relationships of Trisubstituted Pyrimidines/Pyridines as Novel Calcium-Sensing Receptor Antagonists.
J Med Chem 52: 1204-8 (2009)
Bristol-Myers Squibb
Novel heteroaromatic organofluorine inhibitors of fructose-1,6-bisphosphatase.
J Med Chem 52: 878-82 (2009)
University Of Massachusetts
Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants.
J Med Chem 52: 840-51 (2009)
University Of Siena
Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity.
J Med Chem 52: 1050-62 (2009)
National Health Research Institutes
N-[6-amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A receptor antagonists with improved drug like properties and in vivo efficacy.
J Med Chem 52: 709-17 (2009)
Neurocrine Biosciences
Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy.
Bioorg Med Chem Lett 19: 1177-82 (2009)
Gsk
Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization.
Bioorg Med Chem Lett 19: 1168-72 (2009)
Merck Research Laboratories
Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases.
Bioorg Med Chem Lett 19: 1199-205 (2009)
Boehringer Ingelheim (Canada)
Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one.
Bioorg Med Chem Lett 19: 731-4 (2009)
Huazhong University Of Science And Technology
Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases.
J Med Chem 52: 593-6 (2009)
Chinese Academy Of Sciences
Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.
Nat Chem Biol 5: 108-17 (2009)
Vanderbilt University
Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Bioorg Med Chem Lett 19: 584-8 (2009)
University Of Alberta
Discovery of novel small molecule cell type-specific enhancers of NF-kappaB nuclear translocation.
Bioorg Med Chem Lett 19: 1191-4 (2009)
Columbia University
3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment.
Eur J Med Chem 44: 2868-76 (2009)
China Pharmaceutical University
Non-vanillyl resiniferatoxin analogues as potent and metabolically stable transient receptor potential vanilloid 1 agonists.
Bioorg Med Chem 17: 690-8 (2009)
Seoul National University
Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: orally effective anti-inflammatory drug candidates.
Bioorg Med Chem 17: 1125-31 (2009)
Universidade Federal Do Rio De Janeiro
2-Aminoimidazoles inhibitors of TGF-beta receptor 1.
Bioorg Med Chem Lett 19: 912-6 (2009)
Abbott Laboratories
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor ligands: searching for structure-activity relationships.
J Med Chem 52: 601-9 (2009)
University Of Dublin
The translocator protein (18 kDa): central nervous system disease and drug design.
J Med Chem 52: 581-92 (2009)
Brain And Mind Research Institute
Preliminary evaluation of pharmacological properties of some xanthone derivatives.
Bioorg Med Chem 17: 1345-52 (2009)
Jagiellonian University Medical College
N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1).
Bioorg Med Chem Lett 19: 1218-23 (2009)
Methylgene
Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists.
Bioorg Med Chem Lett 19: 597-601 (2009)
Bristol-Myers Squibb
Synthesis and biological evaluation of curcuminoid pyrazoles as new therapeutic agents in inflammatory bowel disease: effect on matrix metalloproteinases.
Bioorg Med Chem 17: 1290-6 (2009)
Uned
Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: a novel, potent and orally active direct inhibitor of factor Xa.
Bioorg Med Chem 17: 1193-206 (2009)
Daiichi Sankyo
Discovery of 2-(alpha-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS.
Bioorg Med Chem Lett 19: 1206-9 (2009)
Cytopia Research
Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice.
Bioorg Med Chem Lett 19: 639-43 (2009)
University Of California
Aryl sulphonyl amides as potent agonists of the growth hormone secretagogue (ghrelin) receptor.
Bioorg Med Chem Lett 19: 684-7 (2009)
Glaxosmithkline
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.
Bioorg Med Chem Lett 19: 1155-8 (2009)
Universita Degli Studi Di Firenze
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques.
Eur J Med Chem 44: 2913-22 (2009)
Jadavpur University
Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.
J Med Chem 52: 655-63 (2009)
Universite De Lyon
Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta.
J Med Chem 52: 858-67 (2009)
Universita Di Pisa
Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.
J Med Chem 52: 779-97 (2009)
Northwestern University
Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain for orally potent antianxiety drug.
J Med Chem 52: 610-25 (2009)
Pfizer
Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.
J Med Chem 52: 718-25 (2009)
Huazhong University Of Science And Technology
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
Nat Chem Biol 5: 100-7 (2009)
University Of Texas Southwestern Medical Center
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.
Bioorg Med Chem 17: 1158-63 (2009)
Balikesir University
Solid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: effect of sulfonamides P3 substituents on potency and selectivity.
Bioorg Med Chem 17: 1307-24 (2009)
Medivir
Towards Gram-negative antivirulence drugs: new inhibitors of HldE kinase.
Bioorg Med Chem 17: 1276-89 (2009)
Mutabilis
A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid.
Bioorg Med Chem 17: 1232-43 (2009)
Daiichi Sankyo
3,4-Disubstituted isothiazoles: novel potent inhibitors of VEGF receptors 1 and 2.
Bioorg Med Chem Lett 19: 1195-8 (2009)
Decode
Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase.
Bioorg Med Chem 17: 1244-50 (2009)
Monash University (Parkville Campus)
Peri-substituted hexahydro-indolones as novel, potent and selective human EP3 receptor antagonists.
Bioorg Med Chem Lett 19: 778-82 (2009)
Decode Chemistry
Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase.
Bioorg Med Chem Lett 19: 665-9 (2009)
Pfizer
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.
Bioorg Med Chem Lett 19: 650-3 (2009)
Centre Scientifique De Monaco
Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET.
J Med Chem 52: 688-99 (2009)
National Institute Of Mental Health
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.
Bioorg Med Chem 17: 1214-21 (2009)
Universita Degli Studi Di Firenze
New N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl phenylcarbamate analogs as sigma2 receptor ligands: synthesis, in vitro characterization, and evaluation as PET imaging and chemosensitization agents.
Bioorg Med Chem 17: 1222-31 (2009)
Washington University
Oxidosqualene cyclase from Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii and Arabidopsis thaliana expressed in yeast: a model for the development of novel antiparasitic agents.
Bioorg Med Chem Lett 19: 718-23 (2009)
Università
Novel imidazole-based histamine H3 antagonists.
Bioorg Med Chem Lett 19: 903-7 (2009)
Johnson & Johnson Pharmaceutical Research & Development
Structure-based virtual screening for novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase and their experimental evaluation.
Bioorg Med Chem 17: 1353-60 (2009)
Northern Kentucky University
New quinoline NK3 receptor antagonists with CNS activity.
Bioorg Med Chem Lett 19: 837-40 (2009)
Neuroscience Cedd Glaxosmithkline Research & Development
Investigation of ketone warheads as alternatives to the nitrile for preparation of potent and selective cathepsin K inhibitors.
Bioorg Med Chem Lett 19: 675-9 (2009)
Merck Frosst Centre For Therapeutic Research
Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.
J Med Chem 52: 868-77 (2009)
University Of Bath
Structure-activity relationship and studies on the molecular mechanism of leishmanicidal N,C-coupled arylisoquinolinium salts.
J Med Chem 52: 626-36 (2009)
University Of WüRzburg
First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery.
J Med Chem 52: 293-307 (2009)
Nerviano Medical Sciences
Homotyrosine-containing cyanopeptolins 880 and 960 and anabaenopeptins 908 and 915 from Planktothrix agardhii CYA 126/8.
J Nat Prod 72: 172-6 (2009)
University Of Hawaii
6-Methoxy-N-alkyl isatin acylhydrazone derivatives as a novel series of potent selective cannabinoid receptor 2 inverse agonists: design, synthesis, and binding mode prediction.
J Med Chem 52: 433-44 (2009)
The University Of Texas M.D. Anderson Cancer Center
Bisubstrate Inhibitors of the MYST HATs Esa1 and Tip60.
Bioorg Med Chem 17: 1381-6 (2009)
Georgia State University
Spiro-piperidine azetidinones as potent TRPV1 antagonists.
Bioorg Med Chem Lett 19: 783-7 (2009)
Schering-Plough Research Institute
3-amido-4-anilinoquinolines as CSF-1R kinase inhibitors 2: Optimization of the PK profile.
Bioorg Med Chem Lett 19: 701-5 (2009)
Astrazeneca R&D Boston
SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).
Bioorg Med Chem Lett 19: 644-9 (2009)
Methylgene
Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor tyrosine kinase inhibitors.
J Med Chem 52: 278-92 (2009)
Novartis Institutes For Biomedical Research
Dual integrin and gastrin-releasing peptide receptor targeted tumor imaging using 18F-labeled PEGylated RGD-bombesin heterodimer 18F-FB-PEG3-Glu-RGD-BBN.
J Med Chem 52: 425-32 (2009)
Stanford University School Of Medicine
Induced association of mu opioid (MOP) and type 2 cholecystokinin (CCK2) receptors by novel bivalent ligands.
J Med Chem 52: 247-58 (2009)
University Of Minnesota
Synthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonists.
J Med Chem 52: 524-9 (2009)
University Of Ferrara
Rigid duplex alpha-cyclodextrin reversibly connected with disulfide bonds. Synthesis and inclusion complexes.
J Org Chem 74: 1082-92 (2009)
Institute Of Organic Chemistry And Biochemistry As Cr
Curcumin is a potent DNA hypomethylation agent.
Bioorg Med Chem Lett 19: 706-9 (2009)
The Ohio State University
Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase.
Bioorg Med Chem Lett 19: 697-700 (2009)
Astrazeneca R&D Boston
Inhibition of the PCAF histone acetyl transferase and cell proliferation by isothiazolones.
Bioorg Med Chem 17: 460-6 (2009)
University Of Groningen
Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors.
Bioorg Med Chem Lett 19: 688-92 (2009)
Methylgene
Second generation 4-(4-methyl-1H-indol-5-ylamino)-2-phenylthieno[2,3-b]pyridine-5-carbonitrile PKCtheta inhibitors.
Bioorg Med Chem Lett 19: 766-9 (2009)
Wyeth Research
Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues.
Bioorg Med Chem Lett 19: 841-4 (2009)
Institut De Recherche Servier
Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors.
Bioorg Med Chem Lett 19: 817-20 (2009)
Glaxosmithkline
Discovery of potent inhibitors of interleukin-2 inducible T-cell kinase (ITK) through structure-based drug design.
Bioorg Med Chem Lett 19: 773-7 (2009)
Boehringer Ingelheim Pharmaceuticals
A series of halogenated heterodimeric inhibitors of prostate specific membrane antigen (PSMA) as radiolabeled probes for targeting prostate cancer.
J Med Chem 52: 347-57 (2009)
Molecular Insight Pharmaceuticals
5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases.
Bioorg Med Chem Lett 19: 745-50 (2009)
Mahidol University
Synthesis and structure-activity relationships of novel, substituted 5,6-dihydrodibenzo[a,g]quinolizinium P2X7 antagonists.
Bioorg Med Chem Lett 19: 954-8 (2009)
Institute Of Science And Technology (Gist)
Exploring QSAR and QAAR for inhibitors of cytochrome P450 2A6 and 2A5 enzymes using GFA and G/PLS techniques.
Eur J Med Chem 44: 1941-51 (2009)
Jadavpur University
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
Eur J Med Chem 44: 1926-32 (2009)
Casmedchem Laboratory
Synthesis of novel 1,4-benzoxazin-3-one derivatives as inhibitors against tyrosine kinases.
Bioorg Med Chem 17: 699-708 (2009)
Santen Pharmaceutical
Potent and selective adenosine A2A receptor antagonists: 1,2,4-Triazolo[1,5-c]pyrimidines.
Bioorg Med Chem Lett 19: 967-71 (2009)
Schering-Plough Research Institute
(-)-Cercosporamide derivatives as novel antihyperglycemic agents.
Bioorg Med Chem Lett 19: 724-6 (2009)
Daiichi Sankyo
Multivalent scaffolds for affinity maturation of small molecule cell surface binders and their application to prostate tumor targeting.
J Med Chem 52: 544-50 (2009)
Justus-Liebig-Universitat Giessen
Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions.
J Med Chem 52: 569-73 (2009)
Universita Di Messina
CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids.
Antimicrob Agents Chemother 53: 1256-9 (2009)
Institute
Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase.
Antimicrob Agents Chemother 53: 1194-203 (2009)
Gilead Sciences
Discovery of 1-[9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist.
J Med Chem 52: 234-7 (2009)
Pfizer
Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia.
J Nat Prod 72: 24-8 (2009)
University Of Delaware
Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease.
J Med Chem 52: 336-46 (2009)
Schering-Plough Research Institute
The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A.
Chembiochem 10: 268-77 (2009)
University Of Toronto
The importance of odorant conformation to the binding and activation of a representative olfactory receptor.
Chem Biol 15: 1317-27 (2008)
Columbia University
Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.
Chem Biol 15: 1296-306 (2008)
University Of Toronto
Discovery of 13-oxa prostaglandin analogs as antiglaucoma agents: synthesis and biological activity.
Bioorg Med Chem 17: 576-84 (2009)
Alcon Research
Arylphthalazines as potent, and orally bioavailable inhibitors of VEGFR-2.
Bioorg Med Chem 17: 731-40 (2009)
Imclone Systems
Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs).
Bioorg Med Chem 17: 467-74 (2009)
The Institute Of Cancer Research
Discovery and structure-activity relationships of a novel series of benzopyran-based K(ATP) openers for urge urinary incontinence.
Bioorg Med Chem 17: 855-66 (2009)
Johnson & Johnson Pharmaceutical Research And Development
Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold.
Bioorg Med Chem 17: 634-40 (2009)
The University Of Kansas
New analogues of agmatine with higher affinity to imidazoline receptors.
Bioorg Med Chem Lett 19: 1009-11 (2009)
Gda£?Sk University Of Technology
Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R).
Bioorg Med Chem Lett 19: 1004-8 (2009)
Glaxosmithkline
Natural products as tools for neuroscience: discovery and development of novel agents to treat drug abuse.
J Nat Prod 72: 581-7 (2009)
University Of Kansas
Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors.
Bioorg Med Chem 17: 553-7 (2009)
University Of Namur
Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead.
Bioorg Med Chem Lett 19: 962-6 (2009)
Vanderbilt University Medical Center
Potent and selective inhibitors of Helicobacter pylori glutamate racemase (MurI): pyridodiazepine amines.
Bioorg Med Chem Lett 19: 930-6 (2009)
Astrazeneca R&D Boston
Synthesis and CB1 cannabinoid receptor affinity of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles.
Bioorg Med Chem Lett 19: 891-3 (2009)
University Of New Orleans
Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone.
Bioorg Med Chem 17: 530-6 (2009)
UniversitäT TüBingen
Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities.
Bioorg Med Chem 17: 558-68 (2009)
Johannes Gutenberg University
Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity.
Bioorg Med Chem Lett 19: 1026-9 (2009)
Astrazeneca R&D Boston
2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitor.
Bioorg Med Chem Lett 19: 908-11 (2009)
Pfizer
Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors.
Bioorg Med Chem Lett 19: 972-5 (2009)
Harvard School Of Public Health
Synthesis of spiro[chroman-2,4'-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors.
Bioorg Med Chem Lett 19: 949-53 (2009)
Torrent Pharmaceuticals
Discovery of thiophene inhibitors of polo-like kinase.
Bioorg Med Chem Lett 19: 1018-21 (2009)
Gsk
5-(2-Pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes: synthesis of all the stereoisomers and alpha4beta2 nicotinic affinity.
Bioorg Med Chem Lett 19: 854-9 (2009)
Università
1-Oxo-3-substitute-isothiochroman-4-carboxylic acid compounds: synthesis and biological activities of FAS inhibition.
Bioorg Med Chem Lett 19: 770-2 (2009)
Institute Of Pharmacology & Toxicology
Stereo-controlled synthesis of novel photoreactive gamma-secretase inhibitors.
Bioorg Med Chem Lett 19: 922-5 (2009)
Memorial Sloan-Kettering Cancer Center
Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors.
Bioorg Med Chem Lett 19: 917-21 (2009)
University Of Tennessee Health Sciences Center
Allosteric inhibitors of Akt1 and Akt2: discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity.
Bioorg Med Chem Lett 19: 834-6 (2009)
Merck Research Laboratories
Interrogating the mechanism of a tight binding inhibitor of AIR carboxylase.
Bioorg Med Chem 17: 794-803 (2009)
Wayne State University
Current perspective of TACE inhibitors: a review.
Bioorg Med Chem 17: 444-59 (2009)
The M. S. University Of Baroda
Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity.
Bioorg Med Chem Lett 19: 1001-3 (2009)
Okayama University Graduate School Of Medicine
Discovery and optimization of highly ligand-efficient oxytocin receptor antagonists using structure-based drug design.
Bioorg Med Chem Lett 19: 990-4 (2009)
Glaxosmithkline
1,2,3-Triazole derivatives as new cannabinoid CB1 receptor antagonists.
Bioorg Med Chem Lett 19: 1022-5 (2009)
National Central University
Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of Type 2 diabetes: 2. Optimization of serine and threonine ether amino acid residues.
Bioorg Med Chem Lett 19: 981-5 (2009)
Glaxosmithkline
Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes: 1. Identification of 1-amino-1-cycloalkyl carboxylic acid headgroups.
Bioorg Med Chem Lett 19: 976-80 (2009)
Glaxosmithkline
Non-peptide macrocyclic histone deacetylase inhibitors.
J Med Chem 52: 456-68 (2009)
Georgia Institute Of Technology
New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Bioorg Med Chem 17: 675-89 (2009)
Hacettepe University
CB2 selective sulfamoyl benzamides: optimization of the amide functionality.
Bioorg Med Chem Lett 19: 309-13 (2008)
Adolor
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 7: syntheses and opioid receptor properties of cyclic variants of cyclazocine.
Bioorg Med Chem Lett 19: 365-8 (2008)
Rensselaer Polytechnic Institute
Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics.
Bioorg Med Chem Lett 19: 538-42 (2008)
Johann Wolfgang Goethe Universit£T
CoMFA and CoMSIA 3D-QSAR studies on S(6)-(4-nitrobenzyl)mercaptopurine riboside (NBMPR) analogs as inhibitors of human equilibrative nucleoside transporter 1 (hENT1).
Bioorg Med Chem Lett 19: 314-8 (2008)
University Of Tennessee Health Sciences Center
Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: synthesis, biological evaluation, and structure-activity relationships.
Bioorg Med Chem Lett 19: 305-8 (2009)
Daiichi Sankyo
Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway.
Bioorg Med Chem Lett 19: 328-31 (2008)
Novartis Institutes For Biomedical Research
A novel sesquiterpene quinone from Hainan sponge Dysidea villosa.
Bioorg Med Chem Lett 19: 390-2 (2008)
Chinese Academy Of Sciences
Inhibitors of tubulin assembly identified through screening a compound library.
Chem Biol Drug Des 72: 513-24 (2008)
The Ohio State University
Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching.
J Med Chem 51: 7882-8 (2008)
Peking University
Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening.
J Med Chem 52: 416-24 (2009)
Yale University
Mechanism of p300 specific histone acetyltransferase inhibition by small molecules.
J Med Chem 52: 267-77 (2009)
Jawaharlal Nehru Centre For Advanced Scientific Research
Sulfamides as novel histone deacetylase inhibitors.
Bioorg Med Chem Lett 19: 336-40 (2008)
Methylgene
Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors.
Eur J Med Chem 44: 1830-7 (2009)
Gazi University
Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.
Eur J Med Chem 44: 1900-12 (2009)
Universit£
Relationships between the structure of 6-allyl-6,8-diazabicyclo[3.2.2]nonane derivatives and their sigma receptor affinity and cytotoxic activity.
Bioorg Med Chem 17: 777-93 (2009)
Institut FüR Pharmazeutische Und Medizinische Chemie Der WestfäLischen Wilhelms-UniversitäT MüNster
Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists.
Bioorg Med Chem Lett 19: 369-72 (2008)
Praecis Pharmaceuticals
Synthesis and initial evaluation of novel, non-peptidic antagonists of the alpha(v)-integrins alpha(v)beta(3) and alpha(v)beta(5).
Bioorg Med Chem Lett 19: 352-5 (2008)
Pharmacopeia
Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R: elimination of an acid-mediated decomposition pathway.
Bioorg Med Chem Lett 19: 373-7 (2008)
Glaxosmithkline
Molecular modeling studies of vascular endothelial growth factor receptor tyrosine kinase inhibitors using QSAR and docking.
J Mol Graph Model 27: 642-54 (2008)
Lanzhou University
Substituted 1,2,3,4-tetrahydroquinolin-6-yloxypropanes as beta3-adrenergic receptor agonists: design, synthesis, biological evaluation and pharmacophore modeling.
Bioorg Med Chem 17: 830-47 (2009)
Central Drug Research Institute
Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II.
Bioorg Med Chem 17: 758-66 (2009)
Università
Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines.
Bioorg Med Chem 17: 64-73 (2008)
Astellas Pharma
Discovery and optimisation of a potent and selective tertiary sulfonamide oxytocin antagonist.
Bioorg Med Chem Lett 19: 528-32 (2008)
Glaxosmithkline
Identification of small molecules that inhibit GSK-3beta through virtual screening.
Bioorg Med Chem Lett 19: 533-7 (2008)
Korea Research Institute Of Chemical Technology
Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex.
Antimicrob Agents Chemother 53: 876-82 (2009)
H�Pital De Bic�Tre
Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae.
Antimicrob Agents Chemother 53: 1157-64 (2009)
Swansea University
Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue.
Antimicrob Agents Chemother 53: 1290-2 (2009)
Vu University Amsterdam
Discovery of potent thermolysin inhibitors using structure based virtual screening and binding assays.
J Med Chem 52: 48-61 (2009)
University Of Tromsø
Selectively targeting T- and B-cell lymphomas: a benzothiazole antagonist of alpha4beta1 integrin.
J Med Chem 52: 14-9 (2009)
University Of California Davis
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.
J Med Chem 52: 151-69 (2009)
University Of Siena
Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.
J Med Chem 52: 74-86 (2009)
Medical University Of South Carolina
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides.
J Med Chem 52: 105-16 (2009)
Wyeth Research
Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors.
J Med Chem 52: 143-50 (2009)
Universidade De Coimbra
Hypoxia-inducible factor-1 inhibitory benzofurans and chalcone-derived diels-alder adducts from Morus species.
J Nat Prod 72: 39-43 (2009)
Korean Research Institute Of Biosciences And Biotechnology
Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors.
J Med Chem 52: 170-80 (2009)
Abbott Laboratories
Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines.
J Med Chem 52: 33-47 (2009)
Vernalis R&D
Pharmacophore guided discovery of small-molecule human apurinic/apyrimidinic endonuclease 1 inhibitors.
J Med Chem 52: 20-32 (2009)
University Of Southern California
Studies on a series of potent, orally bioavailable, 5-HT(1) receptor ligands--part II.
Bioorg Med Chem Lett 19: 428-32 (2008)
Glaxosmithkline
Synthesis and evaluation of pyrido-thieno-pyrimidines as potent and selective Cdc7 kinase inhibitors.
Bioorg Med Chem Lett 19: 319-23 (2009)
Roche
Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity.
Bioorg Med Chem Lett 19: 360-4 (2009)
Gsk
Highly potent 4-amino-indolo[2,3-c]azepin-3-one-containing somatostatin mimetics with a range of sst receptor selectivities.
J Med Chem 52: 95-104 (2009)
Vrije Universiteit Brussel
Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 labeled reboxetine analogues: potential positron emission tomography radioligands for in vivo imaging of the norepinephrine transporter.
J Med Chem 52: 62-73 (2009)
Emory University
Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors.
Bioorg Med Chem Lett 19: 546-9 (2008)
Universidade Federal De Santa Maria
Design, synthesis and characterization of novel 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives as inhibitors of NF-kappaB and AP-1 mediated transcription activation and as potential anti-inflammatory agents.
Eur J Med Chem 44: 2184-9 (2009)
B.V. Patel Pharmaceutical Education And Research Development Centre
Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis.
Bioorg Med Chem 17: 149-64 (2008)
Kyoto University
Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase.
Bioorg Med Chem Lett 19: 424-7 (2008)
Amgen
Discovery of alpha-amidosulfones as potent and selective agonists of CB2: synthesis, SAR, and pharmacokinetic properties.
Bioorg Med Chem Lett 19: 31-5 (2008)
Amgen
Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.
Bioorg Med Chem Lett 19: 433-7 (2008)
Vrije Universiteit Brussel
Lipidyl pseudopteranes A-F: isolation, biomimetic synthesis, and PTP1B inhibitory activity of a new class of pseudopteranoids from the Gorgonian Pseudopterogorgia acerosa.
J Nat Prod 71: 1977-82 (2008)
University Of Prince Edward Island
Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.
Nat Chem Biol 5: 45-52 (2009)
Katholieke Universiteit Leuven
Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2.
Bioorg Med Chem 17: 905-18 (2009)
University Of Oxford
Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2-a]pyridine symbiotic prototypes.
Bioorg Med Chem 17: 74-84 (2008)
Federal University Of Rio De Janeiro
Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase.
Bioorg Med Chem Lett 19: 397-400 (2008)
Ucb Pharma
Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen.
Bioorg Med Chem Lett 19: 418-23 (2008)
Yale University
Synthesis of 2-amino-5-benzoyl-4-(2-furyl)thiazoles as adenosine A(2A) receptor antagonists.
Bioorg Med Chem Lett 19: 378-81 (2008)
Pharmacopeia
Synthesis and neuropharmacological evaluation of esters of R(-)-N-alkyl-11-hydroxy-2-methoxynoraporphines.
Bioorg Med Chem Lett 19: 51-3 (2008)
Harvard Medical School
Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors.
Bioorg Med Chem Lett 19: 27-30 (2008)
Glaxosmithkline
Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives.
Bioorg Med Chem Lett 19: 489-92 (2008)
University Of Lille
Aryl sulfamates are broad spectrum inactivators of sulfatases: effects on sulfatases from various sources.
Bioorg Med Chem Lett 19: 477-80 (2008)
University Of Melbourne
Parallel synthesis, molecular modelling and further structure-activity relationship studies of new acylthiocarbamates as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Eur J Med Chem 44: 2190-201 (2009)
Universit£
Synthesis and evaluation of dithiolethiones as novel cyclooxygenase inhibitors.
Bioorg Med Chem Lett 19: 459-61 (2008)
Institute
Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: potent inhibitors of the IGF-1R receptor tyrosine kinase.
Bioorg Med Chem Lett 19: 469-73 (2009)
Gsk
4-Phenoxybutoxy-substituted heterocycles--a structure-activity relationship study of blockers of the lymphocyte potassium channel Kv1.3.
Eur J Med Chem 44: 1838-52 (2009)
University Of California
Discovery of targeting ligands for breast cancer cells using the one-bead one-compound combinatorial method.
J Med Chem 52: 126-33 (2009)
University Of California
Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH.
Bioorg Med Chem 17: 49-56 (2008)
Ghent University
5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett 19: 451-8 (2009)
Anadys Pharmaceuticals
Discovery of novel spirocyclopropyl hydroxamate and carboxylate compounds as TACE inhibitors.
Bioorg Med Chem Lett 19: 54-7 (2009)
Schering-Plough Research Institute
PEG-immobilization of cardol and soluble polymer-supported synthesis of some cardol-coumarin derivatives: preliminary evaluation of their inhibitory activity on mushroom tyrosinase.
Bioorg Med Chem Lett 19: 36-9 (2008)
Università
QSAR models for 2-amino-6-arylsulfonylbenzonitriles and congeners HIV-1 reverse transcriptase inhibitors based on linear and nonlinear regression methods.
Eur J Med Chem 44: 2158-71 (2009)
Lanzhou University
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties.
J Med Chem 51: 7602-13 (2008)
Universita Degli Studi Di Bari
Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs.
J Med Chem 51: 7751-67 (2008)
University Of London
Search for inhibitors of bacterial and human protein kinases among derivatives of diazepines[1,4] annelated with maleimide and indole cycles.
J Med Chem 51: 7731-6 (2008)
Institute Of General Genetics
Identification of diarylsulfone sulfonamides as secreted frizzled related protein-1 (sFRP-1) inhibitors.
J Med Chem 51: 7670-2 (2008)
Wyeth Research
Radiohalogenated prostate-specific membrane antigen (PSMA)-based ureas as imaging agents for prostate cancer.
J Med Chem 51: 7933-43 (2008)
Institutions
Guanidine-acylguanidine bioisosteric approach in the design of radioligands: synthesis of a tritium-labeled N(G)-propionylargininamide ([3H]-UR-MK114) as a highly potent and selective neuropeptide Y Y1 receptor antagonist.
J Med Chem 51: 8168-72 (2008)
University Of Regensburg
Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.
J Med Chem 51: 7788-99 (2008)
Emory University
Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity.
J Med Chem 51: 7523-31 (2009)
Universita Degli Studi Di Bari
Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design.
J Med Chem 51: 7768-76 (2008)
Consiglio Nazionale Delle Ricerche
Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B.
J Med Chem 51: 8019-26 (2008)
Emory University
New benzylureas as a novel series of potent, nonpeptidic vasopressin V2 receptor agonists.
J Med Chem 51: 8124-34 (2008)
Vantia
Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach.
J Med Chem 51: 7855-65 (2008)
Vrije Universiteit Amsterdam
Synthesis, modeling, and RET protein kinase inhibitory activity of 3- and 4-substituted beta-carbolin-1-ones.
J Med Chem 51: 7777-87 (2008)
Universita Di Milano
Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo.
J Med Chem 51: 7915-20 (2008)
Novartis Institutes For Biomedical Research
Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor.
J Med Chem 51: 7889-97 (2008)
Amgen
New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide.
J Med Chem 51: 7800-5 (2008)
Martin-Luther-Universitaet
Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.
J Med Chem 51: 7968-79 (2008)
Instituto Superior TéCnico
Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: antibacterial nucleosides effective against Mycobacterium tuberculosis.
J Med Chem 51: 7495-507 (2009)
University Of Minnesota
Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities.
J Med Chem 51: 8038-47 (2008)
University Of Utah
Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding characterization at D2/D3 receptors and elucidation of a pharmacophore model.
J Med Chem 51: 7806-19 (2008)
Wayne State University
Probes for narcotic receptor mediated phenomena. 37. Synthesis and opioid binding affinity of the final pair of oxide-bridged phenylmorphans, the ortho- and para-b-isomers and their N-phenethyl analogues, and the synthesis of the N-phenethyl analogues of the ortho- and para-d-isomers.
J Med Chem 51: 7866-81 (2008)
National Institute On Drug Abuse
Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550).
J Med Chem 51: 8012-8 (2008)
National Human Genome Research Institute
Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain.
J Med Chem 51: 7717-30 (2008)
Universit£
Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model.
J Med Chem 51: 7953-67 (2008)
Amgen
Cytochrome P450 2C9 type II binding studies on quinoline-4-carboxamide analogues.
J Med Chem 51: 8000-11 (2008)
Washington State University
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
J Med Chem 51: 8068-76 (2008)
Eberhard Karls University Tuebingen
Development of 3-phenyltropane analogues with high affinity for the dopamine and serotonin transporters and low affinity for the norepinephrine transporter.
J Med Chem 51: 8048-56 (2008)
Research Triangle Institute
Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells.
J Med Chem 51: 8109-14 (2008)
Lund University
NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity.
J Med Chem 51: 7666-9 (2008)
Friedrich-Schiller-University Jena
Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide.
J Med Chem 51: 8057-67 (2008)
Imperial College
In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.
J Med Chem 51: 8077-87 (2008)
Saarland University
Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors.
J Med Chem 51: 7673-88 (2008)
Georgia State University
Potent, orally bioavailable diazabicyclic small-molecule mimetics of second mitochondria-derived activator of caspases.
J Med Chem 51: 8158-62 (2008)
University Of Michigan
Inhibition of inositol phosphorylceramide synthase by the cyclic peptide aureobasidin A.
Antimicrob Agents Chemother 53: 496-504 (2009)
Pharmacia
Tyrosinase inhibitory effects of 1,3-diphenylpropanes from Broussonetia kazinoki.
Bioorg Med Chem 17: 35-41 (2008)
Graduate School Of Gyeongsang National University
Highly efficacious factor Xa inhibitors containing alpha-substituted phenylcycloalkyl P4 moieties.
Bioorg Med Chem Lett 19: 462-8 (2008)
Bristol-Myers Squibb
Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands.
Bioorg Med Chem 17: 242-50 (2008)
Universit£
Gamma-pyrone natural products--a privileged compound class provided by nature.
Bioorg Med Chem 17: 2304-9 (2009)
Institute Of Molecular Physiology
Calculation of binding free energies for non-zinc chelating pyrimidine dicarboxamide inhibitors with MMP-13.
Bioorg Med Chem Lett 19: 47-50 (2008)
Stony Brook University
Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors.
Bioorg Med Chem Lett 19: 442-6 (2008)
Santen Pharmaceutical
Discovery and structure-activity relationships of 4-aminoquinazoline derivatives, a novel class of opioid receptor like-1 (ORL1) antagonists.
Bioorg Med Chem 17: 119-32 (2009)
Nippon Shinyaku
Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors.
Bioorg Med Chem Lett 19: 502-7 (2008)
Shenyang Pharmaceutical University
Synthesis of biflavones having a 6-O-7'' linkage and effects on cyclooxygenase-2 and inducible nitric oxide synthase.
Bioorg Med Chem Lett 19: 74-6 (2008)
Kangwon National University
Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.
Bioorg Med Chem Lett 19: 62-6 (2009)
Wyeth Research
Discovering novel quercetin-3-O-amino acid-esters as a new class of Src tyrosine kinase inhibitors.
Eur J Med Chem 44: 1982-8 (2009)
Chinese Academy Of Sciences
Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells.
Leukemia 23: 477-85 (2009)
Center For Molecular Medicine Of The Austrian Academy Of Sciences
Identification and synthesis of 2,7-diamino-thiazolo[5,4-d]pyrimidine derivatives as TRPV1 antagonists.
Bioorg Med Chem Lett 19: 40-6 (2008)
Johnson & Johnson Pharmaceutical Research And Development
1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors.
Bioorg Med Chem Lett 19: 58-61 (2008)
The State University Of New York
Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).
Bioorg Med Chem Lett 19: 222-5 (2008)
Institute For Medical Research
Modification of the N-terminal sulfonyl residue in 3-amidinophenylalanine-based matriptase inhibitors.
Bioorg Med Chem Lett 19: 67-73 (2008)
Curacyte Discovery
Identification of a small molecule beta-secretase inhibitor that binds without catalytic aspartate engagement.
Bioorg Med Chem Lett 19: 17-20 (2009)
Merck Research Laboratories
Discovery of GSK345931A: An EP(1) receptor antagonist with efficacy in preclinical models of inflammatory pain.
Bioorg Med Chem Lett 19: 497-501 (2008)
Glaxosmithkline
Synthesis of a series of 8-(substituted-phenyl)xanthines and a study on the effects of substitution pattern of phenyl substituents on affinity for adenosine A(1) and A(2A) receptors.
Eur J Med Chem 44: 2122-7 (2009)
University Institute Of Pharmaceutical Sciences
Assessment of chemical coverage of kinome space and its implications for kinase drug discovery.
J Med Chem 51: 7898-914 (2008)
Glaxosmithkline
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects.
Nat Chem Biol 5: 37-44 (2008)
The Scripps Research Institute
Genetic variability among ampC genes from acinetobacter genomic species 3.
Antimicrob Agents Chemother 53: 1177-84 (2009)
Complejo Hospitalario Universitario Juan Canalejo-Inibic
In vitro and in vivo studies to characterize the clearance mechanism and potential cytochrome P450 interactions of anidulafungin.
Antimicrob Agents Chemother 53: 1149-56 (2009)
Pfizer
Comprehensive in vitro analysis of voriconazole inhibition of eight cytochrome P450 (CYP) enzymes: major effect on CYPs 2B6, 2C9, 2C19, and 3A.
Antimicrob Agents Chemother 53: 541-51 (2009)
Indiana University
Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2-d]pyrimidines as EGFR and ErbB-2 inhibitors.
Bioorg Med Chem Lett 19: 21-6 (2009)
Gsk
Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.
Bioorg Med Chem 17: 2276-81 (2009)
Virginia Polytechnic Institute And State University
Design, synthesis and herbicidal activity of new iron chelating motifs for HPPD-inhibitors.
Bioorg Med Chem 17: 4221-9 (2009)
Basf
Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC).
Bioorg Med Chem Lett 19: 87-91 (2008)
Copenhagen University
Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors.
Bioorg Med Chem Lett 19: 230-3 (2008)
Ucb Pharma
Syntheses and opioid receptor binding properties of carboxamido-substituted opioids.
Bioorg Med Chem Lett 19: 203-8 (2008)
Rensselaer Polytechnic Institute
Design, synthesis, and pharmacological and pharmacokinetic evaluation of 3-phenyl-5-pyridyl-1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors.
Bioorg Med Chem Lett 19: 184-7 (2008)
Fuji Yakuhin
2D- and 3D-QSAR of tocainide and mexiletine analogues acting as Na(v)1.4 channel blockers.
Eur J Med Chem 44: 1477-85 (2009)
Universit£
Design and synthesis of novel dihydroquinoline-3-carboxylic acids as HIV-1 integrase inhibitors.
Bioorg Med Chem 17: 2925-35 (2009)
Universit£
QSAR studies on BK channel activators.
Bioorg Med Chem 17: 319-25 (2008)
Universit£
3D-QSAR and QSSR studies of 3,8-diazabicyclo[4.2.0]octane derivatives as neuronal nicotinic acetylcholine receptors by comparative molecular field analysis (CoMFA).
Bioorg Med Chem Lett 19: 127-31 (2008)
Burnham Institute For Medical Research
Synthesis and evaluation of novel photoreactive alpha-amino acid analog carrying acidic and cleavable functions.
Bioorg Med Chem Lett 19: 80-2 (2008)
University Of Toyama
Potent inhibitors of HCV-NS3 protease derived from boronic acids.
Bioorg Med Chem Lett 19: 180-3 (2009)
Schering-Plough Research Institute
3,4-Disubstituted indole acylsulfonamides: a novel series of potent and selective human EP3 receptor antagonists.
Bioorg Med Chem Lett 19: 123-6 (2008)
Decode Chemistry
Synthesis of tyrosinase inhibitory (4-oxo-4H-pyran-2-yl)acrylic acid ester derivatives.
Bioorg Med Chem Lett 19: 188-91 (2008)
Institute Of Science And Technology
Diarylimidazolyl oxadiazole and thiadiazole derivatives as cannabinoid CB1 receptor antagonists.
Bioorg Med Chem Lett 19: 142-5 (2008)
Green Cross
Aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists.
Bioorg Med Chem Lett 19: 158-62 (2008)
Medicines Research Centre
Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?
Bioorg Med Chem Lett 19: 226-9 (2008)
Pfizer
Fragment-based discovery of JAK-2 inhibitors.
Bioorg Med Chem Lett 19: 279-82 (2009)
Sgx Pharmaceuticals
Sulphonamide-based bombesin prodrug analogues for glutathione transferase, useful in targeted cancer chemotherapy.
Eur J Med Chem 44: 2009-16 (2009)
Agricultural University Of Athens
Discovery and development of heat shock protein 90 inhibitors.
Bioorg Med Chem 17: 2225-35 (2009)
Memorial Sloan-Kettering Cancer Center
Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
Antimicrob Agents Chemother 53: 86-94 (2008)
Replidyne
Compounds structurally related to ellagic acid show improved antiplasmodial activity.
Antimicrob Agents Chemother 53: 622-30 (2009)
Justus-Liebig-University
Variety of antiprion compounds discovered through an in silico screen based on cellular-form prion protein structure: Correlation between antiprion activity and binding affinity.
Antimicrob Agents Chemother 53: 765-71 (2009)
Gifu University
Ambuic acid inhibits the biosynthesis of cyclic peptide quormones in gram-positive bacteria.
Antimicrob Agents Chemother 53: 580-6 (2009)
Kyushu University
Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression.
Bioorg Med Chem 17: 337-43 (2008)
Human Biomolecular Research Institute
Camphor sulfonamide derivatives as novel, potent and selective CXCR3 antagonists.
Bioorg Med Chem Lett 19: 114-8 (2008)
Glaxosmithkline
Discovery of a potent, selective and orally bioavailable 3,9-diazaspiro[5.5]undeca-2-one CCR5 antagonist.
Bioorg Med Chem Lett 19: 209-13 (2008)
Roche Palo Alto
Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists.
Bioorg Med Chem Lett 19: 119-22 (2008)
Pharmacopeia
Analogs of methyl-piperidinopyrazole (MPP): antiestrogens with estrogen receptor alpha selective activity.
Bioorg Med Chem Lett 19: 108-10 (2008)
University Of Illinois
Calmodulin inhibitors from the fungus Emericella sp.
Bioorg Med Chem 17: 2167-74 (2009)
Universidad Nacional AutóNoma De MéXico
Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors.
Bioorg Med Chem Lett 19: 264-74 (2008)
University Of Illinois At Chicago
Quantitative structure-activity relationship study of serotonin (5-HT7) receptor inhibitors using modified ant colony algorithm and adaptive neuro-fuzzy interference system (ANFIS).
Eur J Med Chem 44: 1463-70 (2009)
Sharif University Of Technology
Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads.
Bioorg Med Chem 16: 10205-9 (2008)
Christian-Albrechts-University Of Kiel
Identification of pharmacophore model, synthesis and biological evaluation of N-phenyl-1-arylamide and N-phenylbenzenesulfonamide derivatives as BACE 1 inhibitors.
Bioorg Med Chem 16: 10190-7 (2008)
Zhejiang University
New cyclic tetrapeptides from Nonomuraea sp. TA-0426 that inhibit glycine transporter type 1 (GlyT1).
Bioorg Med Chem Lett 18: 6321-3 (2008)
Taisho Pharmaceutical
Binding properties of the C-terminal domain of VIAF.
Chem Biol Drug Des 72: 331-6 (2008)
The Burnham Institute For Medical Research
Design, Synthesis, and Evaluation of Tricyclic, Conformationally Constrained Small-Molecule Mimetics of Second Mitochondria-Derived Activator of Caspases.
J Med Chem 51: 7352-5 (2008)
Shanghai Institute Of Organic Chemistry
Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
J Med Chem 51: 7348-51 (2008)
Wyeth Research
Structure-activity relationship studies of 5-benzylaminoimidazo[1,2-c]pyrimidine-8-carboxamide derivatives as potent, highly selective ZAP-70 kinase inhibitors.
Bioorg Med Chem 17: 284-94 (2009)
Kissei Pharmaceutical
Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids.
Bioorg Med Chem Lett 19: 163-6 (2008)
The University Of Queensland
Urea based CCR3 antagonists employing a tetrahydro-1,3-oxazin-2-one spacer.
Bioorg Med Chem Lett 19: 96-9 (2008)
Bristol-Myers Squibb
The discovery of highly potent CGRP receptor antagonists.
Bioorg Med Chem Lett 19: 214-7 (2008)
Merck
Pyridine-3-carboxamides as novel CB(2) agonists for analgesia.
Bioorg Med Chem Lett 19: 259-63 (2008)
Glaxosmithkline
Flavanones from the stem bark of Erythrina abyssinica.
Bioorg Med Chem 16: 10356-62 (2008)
Korea Research Institute Of Bioscience And Biotechnology (Kribb)
Peptide deformylase inhibitors of Mycobacterium tuberculosis: synthesis, structural investigations, and biological results.
Bioorg Med Chem Lett 18: 6568-72 (2008)
Novartis Institute For Tropical Diseases
Histone deacetylase inhibitors through click chemistry.
J Med Chem 51: 7417-27 (2009)
The Ohio State University
Development of Novel G-Protein-Coupled Receptor 54 Agonists with Resistance to Degradation by Matrix Metalloproteinase.
J Med Chem 51: 7645-9 (2008)
Kyoto University
Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase.
J Med Chem 51: 7449-58 (2008)
Roche Palo Alto
Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin.
J Med Chem 51: 7614-24 (2009)
University Of Auckland
Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists.
J Med Chem 51: 7640-4 (2009)
Nagoya City University
Novel Naphthalene-N-sulfonyl-d-glutamic Acid Derivatives as Inhibitors of MurD, a Key Peptidoglycan Biosynthesis Enzyme.
J Med Chem 51: 7486-94 (2008)
Lek Pharmaceuticals
Synthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate Reductase.
J Med Chem 51: 7532-40 (2008)
University Of Connecticut
Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists.
Bioorg Med Chem 16: 10281-94 (2008)
Università
The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor.
Bioorg Med Chem Lett 18: 6429-36 (2008)
Glaxosmithkline
Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules.
J Med Chem 51: 7514-22 (2009)
Chinoin
Triazine Compounds as Antagonists at Bv8-Prokineticin Receptors.
J Med Chem 51: 7635-9 (2008)
University Of Ferrara
Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor.
J Med Chem 51: 7478-85 (2009)
Neurocrine Biosciences
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