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Insights into Protein-Ligand Interactions in Integrin Complexes: Advances in Structure Determinations.EBI
J Med Chem 63: 5675-5696 (2020)
Pliant Therapeutics
Congenetic Hybrids Derived from Dearomatized Isoprenylated Acylphloroglucinol with Opposite Effects on CaEBI
J Med Chem 63: 1709-1716 (2020)
Chinese Academy of Sciences
Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3.EBI
J Med Chem 63: 1544-1563 (2020)
Guangxi Normal University
VEGFR-2 inhibiting effect and molecular modeling of newly synthesized coumarin derivatives as anti-breast cancer agents.EBI
Bioorg Med Chem 28: (2020)
National Research Centre
A panoramic review of IL-6: Structure, pathophysiological roles and inhibitors.EBI
Bioorg Med Chem 28: (2020)
Punjabi University
Discovery of novel cyclin-dependent kinase (CDK) and histone deacetylase (HDAC) dual inhibitors with potent in vitro and in vivo anticancer activity.EBI
Eur J Med Chem 189: (2020)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs.EBI
J Med Chem 63: 1684-1698 (2020)
Universit£t Bonn
Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL-C Increase In Vivo.EBI
J Med Chem 63: 1660-1670 (2020)
TBA
Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening.EBI
Bioorg Med Chem 28: (2020)
Trinity College
1,2,3-Triazole-Chalcone hybrids: Synthesis, in vitro cytotoxic activity and mechanistic investigation of apoptosis induction in multiple myeloma RPMI-8226.EBI
Eur J Med Chem 189: (2020)
Mansoura University
Structure and Activity Studies of Disulfide-Deficient Analogues of ?O-Conotoxin GeXIVA.EBI
J Med Chem 63: 1564-1575 (2020)
Hainan University
Aromatic-Amine Pendants Produce Highly Potent and Efficacious Mixed Efficacy ?-Opioid Receptor (MOR)/?-Opioid Receptor (DOR) Peptidomimetics with Enhanced Metabolic Stability.EBI
J Med Chem 63: 1671-1683 (2020)
University of Michigan
Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors.EBI
Eur J Med Chem 189: (2020)
Cairo University
Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign.EBI
Eur J Med Chem 189: (2020)
University of Modena and Reggio Emilia
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic.EBI
Eur J Med Chem 189: (2020)
Fudan University
Substituted pteridinones as p90 ribosomal S6 protein kinase (RSK) inhibitors: A structure-activity study.EBI
Bioorg Med Chem 28: (2020)
University of Colorado Anschutz Medical Campus
Discovery of LY3325656: A GPR142 agonist suitable for clinical testing in human.EBI
Bioorg Med Chem Lett 30: (2020)
Lilly China Research and Development Center (LCRDC)
Design, synthesis, and biological evaluation of 1,2,5-oxadiazole-3-carboximidamide derivatives as novel indoleamine-2,3-dioxygenase 1 inhibitors.EBI
Eur J Med Chem 189: (2020)
Chinese Academy of Sciences
Phosphine boranes as less hydrophobic building blocks than alkanes and silanes: Structure-property relationship and estrogen-receptor-modulating potency of 4-phosphinophenol derivatives.EBI
Bioorg Med Chem 28: (2020)
the University of Tokyo
Efficient synthesis of tert-butyl 3-cyano-3-cyclopropyl-2-oxopyrrolidine-4-carboxylates: Highly functionalized 2-pyrrolidinone enabling access to novel macrocyclic Tyk2 inhibitors.EBI
Bioorg Med Chem Lett 30: (2020)
Takeda Pharmaceutical Company Limited
Inhibitors of the Zika virus protease NS2B-NS3.EBI
Bioorg Med Chem Lett 30: (2020)
Australian National University
Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library.EBI
Eur J Med Chem 189: (2020)
University of Michigan Medical School
Nostotrebin 6 Related Cyclopentenediones and ?-Lactones with Broad Activity Spectrum Isolated from the Cultivation Medium of the Cyanobacterium EBI
J Nat Prod 83: 392-400 (2020)
University of Halle-Wittenberg
Chrysosporazines F-M: P-Glycoprotein Inhibitory Phenylpropanoid Piperazines from an Australian Marine Fish Derived Fungus, EBI
J Nat Prod 83: 497-504 (2020)
The University of Queensland
Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation.EBI
Eur J Med Chem 189: (2020)
Egyptian Russian University
Synthesis, biological evaluation and in silico modeling of novel integrase strand transfer inhibitors (INSTIs).EBI
Eur J Med Chem 189: (2020)
Chemical Diversity Research Institute
1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors.EBI
J Med Chem 63: 2470-2488 (2020)
Sapienza University of Rome
Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections.EBI
J Med Chem 63: 1313-1327 (2020)
National Taiwan Normal University
?-Helix-Mimicking Sulfono-?-AApeptide Inhibitors for p53-MDM2/MDMX Protein-Protein Interactions.EBI
J Med Chem 63: 975-986 (2020)
University of South Florida
Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins.EBI
J Med Chem 63: 2489-2510 (2020)
National Institute of Chemistry
Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor.EBI
J Med Chem 63: 1612-1623 (2020)
FORMA Therapeutics, Inc.
Isocadiolides A-H: Polybrominated Aromatics from a EBI
J Nat Prod 83: 429-437 (2020)
Seoul National University
Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5.EBI
J Med Chem 63: 1415-1433 (2020)
St. Jude Children's Research Hospital
Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors.EBI
J Med Chem 63: 1642-1659 (2020)
National Health Research Institutes
Kinase-Inhibitory Nucleoside Derivatives from the Pacific Bryozoan EBI
J Nat Prod 83: 547-551 (2020)
Victoria University of Wellington
Design and synthesis of (E)-1,2-diphenylethene-based EZH2 inhibitors.EBI
Bioorg Med Chem Lett 30: (2020)
Sichuan University and Collaborative Innovation Center
Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders.EBI
J Med Chem 63: 1068-1083 (2020)
Novartis Institutes for BioMedical Research
Synthesis and biological evaluation of FICZ analogues as agonists of aryl hydrocarbon receptor.EBI
Bioorg Med Chem Lett 30: (2020)
University of Wisconsin-Madison
Discovery of a novel unsymmetrical structural class of HCV NS5A inhibitors with low picomolar antiviral activity.EBI
Bioorg Med Chem Lett 30: (2020)
Japan Tobacco Inc.
Synthesis and biological evaluation of bis-NEBI
Bioorg Med Chem Lett 30: (2020)
Rhodes University
Potent non-hydroxamate inhibitors of histone deacetylase-8: Role and scope of an isoindolin-2-yl linker with an ?-amino amide as the zinc-binding unit.EBI
Bioorg Med Chem Lett 30: (2020)
University College London
Discovery of a lead series of potent benzodiazepine 5-HTEBI
Bioorg Med Chem Lett 30: (2020)
Arena Pharmaceuticals
Discovery and Structure-Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson's Disease Models.EBI
J Med Chem 63: 2688-2704 (2020)
Astraea Therapeutics
Identification of potent pyrazole based APELIN receptor (APJ) agonists.EBI
Bioorg Med Chem 28: (2020)
RTI International
Design and synthesis of ?-naphthoflavone chimera derivatives able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation.EBI
Eur J Med Chem 189: (2020)
Hunan Agricultural University
A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents.EBI
Eur J Med Chem 188: (2020)
Assam University (A Central University)
Discovery of Potent, Selective, and Direct Acid Sphingomyelinase Inhibitors with Antidepressant Activity.EBI
J Med Chem 63: 961-974 (2020)
China Pharmaceutical University
Stilbenes with Potent Protein Tyrosine Phosphatase-1B Inhibitory Activity from the Roots of EBI
J Nat Prod 83: 323-332 (2020)
Kyungpook National University
Multi-target dopamine D3 receptor modulators: Actionable knowledge for drug design from molecular dynamics and machine learning.EBI
Eur J Med Chem 188: (2020)
Consiglio Nazionale Delle Ricerche (ICRM-CNR)
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.EBI
J Med Chem 63: 3868-3880 (2020)
Genomics Institute of the Novartis Research Foundation (GNF)
Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia.EBI
ACS Med Chem Lett 11: 56-64 (2020)
University of Toronto Mississauga
Nicotinamide Phosphoribosyltransferase (NAMPT) Is a New Target of Antitumor Agent Chidamide.EBI
ACS Med Chem Lett 11: 40-44 (2020)
Second Military Medical University
Epimers Switch Galectin-9 Domain Selectivity: 3EBI
ACS Med Chem Lett 11: 34-39 (2020)
Lund University
Discovery of VU6015929: A Selective Discoidin Domain Receptor 1/2 (DDR1/2) Inhibitor to Explore the Role of DDR1 in Antifibrotic Therapy.EBI
ACS Med Chem Lett 11: 29-33 (2020)
Vanderbilt University
Fluorescence Labeling of Neurotensin(8-13) via Arginine Residues Gives Molecular Tools with High Receptor Affinity.EBI
ACS Med Chem Lett 11: 16-22 (2020)
University of Regensburg
Novel Pyrazolyl-dihydroisoquinolines as Positive Allosteric Modulator of the Dopamine D1 Receptor.EBI
ACS Med Chem Lett 11: (2020)
Arrival Discovery LLC
Novel Methyl-aza-quinazolines as Inhibitors of the RAS-SOS Interaction.EBI
ACS Med Chem Lett 11: 2-3 (2020)
Arrival Discovery LLC
Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel.EBI
J Med Chem 63: 1298-1312 (2020)
Shandong University
Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer.EBI
J Med Chem 63: 1281-1297 (2020)
China Pharmaceutical University
Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine.EBI
J Med Chem 63: 1624-1641 (2020)
Harvard Medical School
Novel Class of Colony-Stimulating Factor 1 Receptor Kinase Inhibitors Based on an EBI
J Med Chem 63: 1397-1414 (2020)
Chinese Academy of Sciences
1-(2'-Bromobenzyl)-6,7-dihydroxy-EBI
J Nat Prod 83: 127-133 (2020)
Universidad de Santiago de Compostela
Identification of novel GPR81 agonist lead series for target biology evaluation.EBI
Bioorg Med Chem Lett 30: (2020)
AstraZeneca
Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa.EBI
Bioorg Med Chem Lett 30: (2020)
Bristol-Myers Squibb Company
Suitable fusion of N-terminal heptad repeats to achieve covalently stabilized potent N-peptide inhibitors of HIV-1 infection.EBI
Bioorg Med Chem 28: (2020)
Nankai University
Design, synthesis and biological evaluation of novel TR? selective agonists sustained by ADME-toxicity analysis.EBI
Eur J Med Chem 188: (2020)
University of Pisa
The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease.EBI
J Med Chem 63: 5031-5073 (2020)
Terns Pharmaceuticals
Benzopyrimidodiazepinone inhibitors of TNK2.EBI
Bioorg Med Chem Lett 30: (2020)
Harvard Medical School
A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors.EBI
J Med Chem 63: 987-1001 (2020)
Dalian University of Technology
Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of type 1 diabetes.EBI
Eur J Med Chem 188: (2020)
Shiv Nadar University
One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor.EBI
Eur J Med Chem 188: (2020)
King Khalid University
Emerging small-molecule therapeutic approaches for amyotrophic lateral sclerosis and frontotemporal dementia.EBI
Bioorg Med Chem Lett 30: (2020)
AstraZeneca
The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119.EBI
Eur J Med Chem 188: (2020)
Chinese Academy of Medical Sciences&Peking Union Medical College
Synthesis and biological evaluation of 2-quinolineacrylamides.EBI
Bioorg Med Chem 28: (2020)
Kaohsiung Medical University
Spirobiflavonoid stereoisomers from the endangered conifer Glyptostrobus pensilis and their protein tyrosine phosphatase 1B inhibitory activity.EBI
Bioorg Med Chem Lett 30: (2020)
Fudan University
Development of novel NLRP3-XOD dual inhibitors for the treatment of gout.EBI
Bioorg Med Chem Lett 30: (2020)
Soochow University
Molecular design, synthesis, and biological evaluation of bisamide derivatives as cyclophilin A inhibitors for HCV treatment.EBI
Eur J Med Chem 188: (2020)
Chonnam National University
Design, synthesis, biological evaluation and molecular docking study of novel thieno[3,2-d]pyrimidine derivatives as potent FAK inhibitors.EBI
Eur J Med Chem 188: (2020)
Shenyang Pharmaceutical University
Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery.EBI
J Med Chem 63: 1156-1177 (2020)
University of Copenhagen
Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria.EBI
Bioorg Med Chem 28: (2020)
Larkin University
Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B.EBI
J Med Chem 63: 1361-1387 (2020)
University of Ljubljana
Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine's Biological Activity.EBI
J Med Chem 63: 5119-5138 (2020)
University of Florida
Fragment-to-Lead Medicinal Chemistry Publications in 2018.EBI
J Med Chem 63: 4430-4444 (2020)
Frontier Medicines
Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present).EBI
J Med Chem 63: 4445-4467 (2020)
University of Zambia
Discovery of 6'-chloro-N-methyl-5'-(phenylsulfonamido)-[3,3'-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium.EBI
Eur J Med Chem 188: (2020)
Chinese Academy of Sciences
Current progress in antimalarial pharmacotherapy and multi-target drug discovery.EBI
Eur J Med Chem 188: (2020)
International Medical University
Development of Novel EBI
J Med Chem 63: 1051-1067 (2020)
East China University of Science and Technology
Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors.EBI
J Med Chem 63: 1337-1360 (2020)
Chinese Academy of Sciences
Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity.EBI
J Med Chem 63: 529-541 (2020)
TBA
Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.EBI
J Med Chem 63: 621-637 (2020)
A*STAR
Synthesis and Structure-Activity Relationship Studies of C2-Modified Analogs of the Antimycobacterial Natural Product Pyridomycin.EBI
J Med Chem 63: 1105-1131 (2020)
ETH Zurich
Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.EBI
J Med Chem 63: 714-746 (2020)
GSK
Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols.EBI
Bioorg Med Chem 28: (2020)
The University of Tokyo
Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice.EBI
Eur J Med Chem 188: (2020)
Jagiellonian University Medical College
N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification.EBI
Eur J Med Chem 188: (2020)
Chinese Academy of Medical Sciences&Peking Union Medical College
Pyrrolo and pyrrolopyrimidine sulfonamides act as cytotoxic agents in hypoxia via inhibition of transmembrane carbonic anhydrases.EBI
Eur J Med Chem 188: (2020)
Cairo University
Design, synthesis and anti-Alzheimer's disease activity study of xanthone derivatives based on multi-target strategy.EBI
Bioorg Med Chem Lett 30: (2020)
Tianjin University of Traditional Chinese Medicine
Selective acetylcholinesterase inhibitors derived from muscle relaxant dantrolene.EBI
Bioorg Med Chem Lett 30: (2020)
Tokyo University of Pharmacy and Life Sciences
Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators.EBI
Bioorg Med Chem Lett 30: (2020)
Biogen
Design and biological evaluation of tetrahydropyridine derivatives as novel human GPR119 agonists.EBI
Bioorg Med Chem Lett 30: (2020)
Sichuan University
?-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors from EBI
J Nat Prod 83: 675-683 (2020)
University of North Carolina Greensboro
Synthesis and Biological Evaluation of B-Cell Lymphoma 6 Inhibitors of EBI
J Med Chem 63: 676-695 (2020)
East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine
Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders.EBI
J Med Chem 63: 1216-1232 (2020)
Icahn School of Medicine at Mount Sinai
Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity.EBI
J Med Chem 63: 1178-1198 (2020)
Virginia Tech
Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-EBI
J Med Chem 63: 1084-1104 (2020)
Takeda Pharmaceutical Company, Ltd.
Systematic Investigation of Lipophilicity Modulation by Aliphatic Fluorination Motifs.EBI
J Med Chem 63: 1002-1031 (2020)
University of Southampton
Thiazolidine-2,4-dione-based irreversible allosteric IKK-? kinase inhibitors: Optimization into in vivo active anti-inflammatory agents.EBI
Eur J Med Chem 188: (2020)
Korea Institute of Science and Technology (KIST)
Isolation of a High-Affinity Cannabinoid for the Human CB1 Receptor from a Medicinal EBI
J Nat Prod 83: 88-98 (2020)
University of Modena and Reggio Emilia
Evaluation of anti-depressant effects of phthalazinone-based triple-acting small molecules against 5-HTEBI
Bioorg Med Chem Lett 30: (2020)
Korea Institute of Science and Technology
Addressing hERG activity while maintaining favorable potency, selectivity and pharmacokinetic properties of PPAR? modulators.EBI
Bioorg Med Chem Lett 30: (2020)
Mitobridge, Inc.
Synthesis and cytotoxic evaluation of halogenated ?-exo-methylene-lactones.EBI
Bioorg Med Chem 28: (2020)
Jinan University
Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents.EBI
Eur J Med Chem 187: (2020)
The Pennsylvania State University College of Medicine
A 18?-glycyrrhetinic acid conjugate with Vorinostat degrades HDAC3 and HDAC6 with improved antitumor effects.EBI
Eur J Med Chem 188: (2020)
Shenyang Pharmaceutical University
Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HTEBI
Bioorg Med Chem 28: (2020)
Northeastern University
Discovery of 5-(pyridin-3-yl)-1H-indole-4,7-diones as indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.EBI
Bioorg Med Chem Lett 30: (2020)
Fudan University
Discovery of small molecule antagonists of chemokine receptor CXCR6 that arrest tumor growth in SK-HEP-1 mouse xenografts as a model of hepatocellular carcinoma.EBI
Bioorg Med Chem Lett 30: (2020)
Sanford Burnham Prebys Medical Discovery Institute
Synthesis and biological evaluation of 4-arylcoumarins as potential anti-Alzheimer's disease agents.EBI
Bioorg Med Chem Lett 30: (2020)
University of Jinan-Shandong Academy of Medical Sciences
Design, synthesis and biological evaluation of indole-2-carboxylic acid derivatives as IDO1/TDO dual inhibitors.EBI
Eur J Med Chem 188: (2020)
Chinese Academy of Medical Sciences&Peking Union Medical College
[1,2,3]Triazolo[4,5-d]pyrimidine derivatives incorporating (thio)urea moiety as a novel scaffold for LSD1 inhibitors.EBI
Eur J Med Chem 187: (2020)
Henan University of Chinese Medicine
Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor ?t inverse agonists for the treatment of autoimmune diseases.EBI
Eur J Med Chem 187: (2020)
Fudan University
Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer.EBI
J Med Chem 63: 696-713 (2020)
Second Military Medical University
Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties.EBI
Bioorg Med Chem Lett 30: (2020)
Yale University
Identification of human lactate dehydrogenase A inhibitors with anti-osteosarcoma activity through cell-based phenotypic screening.EBI
Bioorg Med Chem Lett 30: (2020)
Jilin University China-Japan Union Hospital
Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group.EBI
Bioorg Med Chem Lett 30: (2020)
University of Tsukuba
Variegatic acid from the edible mushroom Tylopilus ballouii inhibits TNF-? production and PKC?1 activity in leukemia cells.EBI
Bioorg Med Chem Lett 30: (2020)
Tokyo University of Agriculture
Recent advances in the discovery and development of glyoxalase I inhibitors.EBI
Bioorg Med Chem 28: (2020)
Chengdu University
Bisphenol AF: Halogen bonding effect is a major driving force for the dual ER?-agonist and ER?-antagonist activities.EBI
Bioorg Med Chem 28: (2020)
Kyushu University
Structural insights into the active site of poly(ADP-ribose) glycohydrolase using docking modes of 6-hydroxy-3H-xanthen-3-one derivative inhibitors.EBI
Bioorg Med Chem 28: (2020)
Tokyo University of Science
Design, synthesis and evaluation of protein disulfide isomerase inhibitors with nitric oxide releasing activity.EBI
Bioorg Med Chem Lett 30: (2020)
Northwestern Polytechnical University (NPU)
Discovery of a follistatin-derived myostatin inhibitory peptide.EBI
Bioorg Med Chem Lett 30: (2020)
Tokyo University of Pharmacy and Life Sciences
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors.EBI
Bioorg Med Chem 28: (2020)
"A. Moro" University of Bari
Imidazolidine-2,4,5- and pirimidine-2,4,6-triones - New primary pharmacophore for soluble epoxide hydrolase inhibitors with enhanced water solubility.EBI
Bioorg Med Chem Lett 30: (2020)
University of California Davis
Design, synthesis and biological evaluation of 2-amino-4-(1,2,4-triazol)pyridine derivatives as potent EGFR inhibitors to overcome TKI-resistance.EBI
Eur J Med Chem 187: (2020)
Southern Medical University
Synthesis and biological activity of thieno[3,2-d]pyrimidines as potent JAK3 inhibitors for the treatment of idiopathic pulmonary fibrosis.EBI
Bioorg Med Chem 28: (2020)
Dalian Medical University
Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer's disease.EBI
Eur J Med Chem 187: (2020)
Nanyang Normal University
Synthesis and immunostimulatory activity of sugar-conjugated TLR7 ligands.EBI
Bioorg Med Chem Lett 30: (2020)
Kagoshima University
Discovery of indane propanamides as potent and selective TRPV1 antagonists.EBI
Bioorg Med Chem Lett 30: (2020)
Seoul National University
Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.EBI
Bioorg Med Chem Lett 30: (2020)
Universidade de Lisboa
Synthesis of novel 2-pyrrolidinone and pyrrolidine derivatives and study of their inhibitory activity against autotaxin enzyme.EBI
Bioorg Med Chem 28: (2020)
National and Kapodistrian University of Athens
Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.EBI
Bioorg Med Chem Lett 30: (2020)
University College London
Discovery of novel 2,4-disubstituted pyrimidines as Aurora kinase inhibitors.EBI
Bioorg Med Chem Lett 30: (2020)
Lanzhou University
Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254).EBI
Bioorg Med Chem 28: (2020)
AstraZeneca
Structure-Activity Relationship in Pyrazolo[4,3-EBI
J Med Chem 63: 847-879 (2020)
Technische Universit£t M£nchen
Phloroglucinol Benzophenones and Xanthones from the Leaves of EBI
J Nat Prod 83: 164-168 (2020)
University of Wollongong
Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.EBI
J Med Chem 63: 1528-1543 (2020)
Sosei Heptares
Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.EBI
J Med Chem 63: 827-846 (2020)
University of Tennessee Health Science Center
Discovery of BAY-985, a Highly Selective TBK1/IKK? Inhibitor.EBI
J Med Chem 63: 601-612 (2020)
Bayer AG
Synthesis and evaluation of 4-(1,3,4-oxadiazol-2-yl)-benzenesulfonamides as potent carbonic anhydrase inhibitors.EBI
Bioorg Med Chem Lett 30: (2020)
Northwest A&F University
Synthesis and biological evaluation of Isosteviol derivatives as FXa inhibitors.EBI
Bioorg Med Chem Lett 30: (2020)
Peking University
Synthesis and biological evaluation of Vinpocetine derivatives.EBI
Bioorg Med Chem Lett 30: (2020)
Peking University
Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.EBI
J Med Chem 63: 656-675 (2020)
Frederick National Laboratory for Cancer Research
Pharmacokinetics-Driven Optimization of 7-Methylimidazo[1,5-EBI
ACS Med Chem Lett 10: 1680-1685 (2019)
China Pharmaceutical University
Discovery of Novel Neuraminidase Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay.EBI
ACS Med Chem Lett 10: 1667-1673 (2019)
Shanghai Institute of Technology
Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1.EBI
ACS Med Chem Lett 10: 1661-1666 (2019)
Goethe-University Frankfurt
New Potent DOT1L Inhibitors for EBI
ACS Med Chem Lett 10: 1655-1660 (2019)
Novartis Institutes for Biomedical Research
Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains.EBI
ACS Med Chem Lett 10: 1648-1654 (2019)
University of Minnesota
Discovery of Axelopran (TD-1211): A Peripherally Restricted ?-Opioid Receptor Antagonist.EBI
ACS Med Chem Lett 10: 1641-1647 (2019)
Theravance Biopharma US, Inc.
Tetrazole as a Replacement of the Electrophilic Group in Characteristic Prolyl Oligopeptidase Inhibitors.EBI
ACS Med Chem Lett 10: 1635-1640 (2019)
University of Helsinki
Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors.EBI
ACS Med Chem Lett 10: 1628-1634 (2019)
University of Michigan
In Silico Discovery of JMJD6 Inhibitors for Cancer Treatment.EBI
ACS Med Chem Lett 10: 1609-1613 (2019)
Xiamen University
Modulation of Tropomyosin Receptor Kinase for the Treatment of Neurotrophin Diseases: Alzheimer's, Huntington's and Parkinson's.EBI
ACS Med Chem Lett 10: 1590-1591 (2019)
Usona Institute
Identification of new potent AEBI
Eur J Med Chem 187: (2020)
Nankai University
Synthesis and in Vitro and in Vivo Biological Evaluation of Tissue-Specific Bisthiazole Histone Deacetylase (HDAC) Inhibitors.EBI
J Med Chem 63: 804-815 (2020)
Chinese Academy of Sciences
Discovery and Characterization of 1EBI
J Med Chem 63: 569-590 (2020)
East China Normal University
Optimization of Orally Bioavailable PI3K? Inhibitors and Identification of Vps34 as a Key Selectivity Target.EBI
J Med Chem 63: 638-655 (2020)
GlaxoSmithKline
Binding Loop Substitutions in the Cyclic Peptide SFTI-1 Generate Potent and Selective Chymase Inhibitors.EBI
J Med Chem 63: 816-826 (2020)
The University of Queensland
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-EBI
J Med Chem 63: 3461-3471 (2020)
AstraZeneca
Engineering a Potent, Long-Acting, and Periphery-Restricted Oxytocin Receptor Agonist with Anorexigenic and Body Weight Reducing Effects.EBI
J Med Chem 63: 382-390 (2020)
Calibr at The Scripps Research Institute
Discovery of 4,6-pyrimidinediamine derivatives as novel dual EGFR/FGFR inhibitors aimed EGFR/FGFR1-positive NSCLC.EBI
Eur J Med Chem 187: (2020)
Wenzhou Medical University
Development of selective mono or dual PROTAC degrader probe of CDK isoforms.EBI
Eur J Med Chem 187: (2020)
Sichuan University and Collaborative Innovation Center of Biotherapy
Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-EBI
J Med Chem 63: 756-783 (2020)
Northeastern University
Docking Finds GPCR Ligands in Dark Chemical Matter.EBI
J Med Chem 63: 613-620 (2020)
Uppsala University
Discovery of Novel Dual Poly(ADP-ribose)polymerase and Phosphoinositide 3-Kinase Inhibitors as a Promising Strategy for Cancer Therapy.EBI
J Med Chem 63: 122-139 (2020)
TBA
Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists.EBI
J Med Chem 63: 2194-2208 (2020)
University of Minnesota
Small molecules targeting HIF-1? pathway for cancer therapy in recent years.EBI
Bioorg Med Chem 28: (2020)
Shandong University
Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.EBI
Bioorg Med Chem 28: (2020)
Guru Nanak Dev University
Thiophene bioisosteres of GluN2B selective NMDA receptor antagonists: Synthesis and pharmacological evaluation of [7]annuleno[b]thiophen-6-amines.EBI
Bioorg Med Chem 28: (2020)
Westf£lische Wilhelms-Universit£t M£nster
Design and synthesis of boron-containing diphenylpyrimidines as potent BTK and JAK3 dual inhibitors.EBI
Bioorg Med Chem 28: (2020)
Chia Tai Tianqing Pharmaceutical Group Co., Ltd
Identification of 6'-?-fluoro-homoaristeromycin as a potent inhibitor of chikungunya virus replication.EBI
Eur J Med Chem 187: (2020)
Seoul National University
Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer.EBI
Eur J Med Chem 187: (2020)
Balikesir University
Structure-Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters.EBI
J Med Chem 63: 391-417 (2020)
University of Vienna
Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery.EBI
J Med Chem 63: 5013-5030 (2020)
Sun Yat-sen University
Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1.EBI
J Med Chem 63: 103-121 (2020)
Kansas University Specialized Chemistry Center
Discovery of EBI
J Med Chem 63: 425-432 (2020)
Christian-Albrechts-University Kiel
Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1.EBI
Bioorg Med Chem Lett 30: (2020)
Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF)
Selective Blockade of Neuronal BK (? + ?4) Channels Preventing Epileptic Seizure.EBI
J Med Chem 63: 216-230 (2020)
Chinese Academy of Sciences
Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment.EBI
Eur J Med Chem 187: (2020)
Taipei Medical University
Discovery of novel pyrrolo[2,3-b]pyridine derivatives bearing 4-oxoquinoline moiety as potential antitumor inhibitor.EBI
Bioorg Med Chem Lett 30: (2020)
Shanghai Institute of Technology
Licochalcone A suppresses the proliferation of sarcoma HT-1080 cells, as a selective R132C mutant IDH1 inhibitor.EBI
Bioorg Med Chem Lett 30: (2020)
Guizhou Medcial University
Discovery of novel 1,2,3-triazole oseltamivir derivatives as potent influenza neuraminidase inhibitors targeting the 430-cavity.EBI
Eur J Med Chem 187: (2020)
Shandong University
Therapeutic significance of ?-glucuronidase activity and its inhibitors: A review.EBI
Eur J Med Chem 187: (2020)
University of KwaZulu-Natal
Potent, Efficacious, and Stable Cyclic Opioid Peptides with Long Lasting Antinociceptive Effect after Peripheral Administration.EBI
J Med Chem 63: 2673-2687 (2020)
Universit£ di Chieti-Pescara "G. d'Annunzio"
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.EBI
J Med Chem 63: 433-439 (2020)
University of Florida
Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups.EBI
J Med Chem 63: 784-803 (2020)
Bristol-Myers Squibb Company
Synthesis and biological evaluation of novel pyrazolo[1,5-a]pyrimidines: Discovery of a selective inhibitor of JAK1 JH2 pseudokinase and VPS34.EBI
Bioorg Med Chem Lett 30: (2020)
Brigham Young University
Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening.EBI
Bioorg Med Chem 28: (2020)
Siberian Branch of Russian Academy of Sciences
Tetrahydroquinoline units in flexible heteroarotinoids (Flex-Hets) convey anti-cancer properties in A2780 ovarian cancer cells.EBI
Bioorg Med Chem 28: (2020)
Oklahoma State University
Design, synthesis and structure-activity relationship of indolylindazoles as potent and selective covalent inhibitors of interleukin-2 inducible T-cell kinase (ITK).EBI
Eur J Med Chem 187: (2020)
Peking University
Synthesis and structure-activity relationship studies of ?-naphthoflavone derivatives as CYP1B1 inhibitors.EBI
Eur J Med Chem 187: (2020)
Shanghai Jiao Tong University
Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate.EBI
J Med Chem 63: 2638-2655 (2020)
CSIC
Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor ?t (ROR?t) Inverse Agonists.EBI
J Med Chem 63: 241-259 (2020)
Technische Universiteit Eindhoven
Design, Synthesis, and Biological Evaluation of Amidobenzimidazole Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists.EBI
J Med Chem 63: 260-282 (2020)
Peking Union Medical College and Chinese Academy of Medical Sciences
Kinetic Target-Guided Synthesis: Reaching the Age of Maturity.EBI
J Med Chem 63: 3817-3833 (2020)
Univ. Lille
Discovery of a Covalent Inhibitor of KRASEBI
J Med Chem 63: 52-65 (2020)
TBA
Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective.EBI
J Med Chem 63: 3785-3816 (2020)
China Pharmaceutical University
Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity.EBI
J Med Chem 63: 369-381 (2020)
Comenius University in Bratislava
Exploring structure-promiscuity relationships using dual-site promiscuity cliffs and corresponding single-site analogs.EBI
Bioorg Med Chem 28: (2020)
Rheinische Friedrich-Wilhelms-Universit£t
Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator.EBI
Bioorg Med Chem 28: (2020)
Array BioPharma Inc.
Identification of small-molecule urea derivatives as novel NAMPT inhibitors via pharmacophore-based virtual screening.EBI
Bioorg Med Chem 28: (2020)
Gazi University
Discovery of coumarin-based selective aldehyde dehydrogenase 1A1 inhibitors with glucose metabolism improving activity.EBI
Eur J Med Chem 187: (2020)
China Pharmaceutical University
Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators.EBI
J Med Chem 63: 163-185 (2020)
University Federico II of Naples
Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.EBI
Bioorg Med Chem 28: (2020)
China Pharmaceutical University
1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease.EBI
Eur J Med Chem 187: (2020)
Jagiellonian University Medical College
Synthesis and discovery of triazolo-pyridazine-6-yl-substituted piperazines as effective anti-diabetic drugs; evaluated over dipeptidyl peptidase-4 inhibition mechanism and insulinotropic activities.EBI
Eur J Med Chem 187: (2020)
Government Arts College
Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors.EBI
Eur J Med Chem 187: (2020)
Cairo University
Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology.EBI
Bioorg Med Chem 28: (2020)
University of Auckland
Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents.EBI
Eur J Med Chem 187: (2020)
University of Auckland
Synthesis and evaluation of the HIF-1? inhibitory activity of 3(5)-substituted-4-(quinolin-4-yl)- and 4-(2-phenylpyridin-4-yl)pyrazoles as inhibitors of ALK5.EBI
Bioorg Med Chem Lett 30: (2020)
Yanbian University
Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors.EBI
J Med Chem 63: 349-368 (2020)
Instituto de Qu£mica M£dica (IQM-CSIC)
Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions.EBI
J Nat Prod 82: 3386-3393 (2019)
University of Utah
Structural optimization of aminopyrimidine-based CXCR4 antagonists.EBI
Eur J Med Chem 187: (2020)
Soochow University
Optimization and evaluation of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as ATX inhibitors for cardiac and hepatic fibrosis.EBI
Eur J Med Chem 187: (2020)
Shenyang Pharmaceutical University
Pyridin-2(1H)one derivatives: A possible new class of therapeutics for mechanical allodynia.EBI
Eur J Med Chem 187: (2020)
Universit£ Clermont Auvergne
Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor ?.EBI
Bioorg Med Chem 28: (2020)
Seoul National University
Optimization of LpxC Inhibitor Lead Compounds Focusing on Efficacy and Formulation for High Dose Intravenous Administration.EBI
J Med Chem 63: 88-102 (2020)
Idorsia Pharmaceuticals Ltd.
Peptide-?-lactam Inhibitors of Dengue and West Nile Virus NS2B-NS3 Protease Display Two Distinct Binding Modes.EBI
J Med Chem 63: 140-156 (2020)
Heidelberg University
Design, Synthesis, and Biological Evaluation of MEK PROTACs.EBI
J Med Chem 63: 157-162 (2020)
Pharmaron Beijing Company
Synthesis and Characterization of an A6-A11 Methylene Thioacetal Human Insulin Analogue with Enhanced Stability.EBI
J Med Chem 62: 11437-11443 (2019)
University of Utah
Glucoconjugated Monoterpene Indole Alkaloids from EBI
J Nat Prod 82: 3288-3301 (2019)
Peking University Health Science Center
Novel Cell-Penetrating Peptide Conjugated Proteasome Inhibitors: Anticancer and Antifungal Investigations.EBI
J Med Chem 63: 334-348 (2020)
University of Auckland
A Novel Decalin-Based Bicyclic Scaffold for FKBP51-Selective Ligands.EBI
J Med Chem 63: 231-240 (2020)
Max Planck Institute of Psychiatry
Polypropionate Derivatives with EBI
J Nat Prod 82: 3440-3449 (2019)
Guangdong Institute of Microbiology
"A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII.EBI
J Med Chem 63: 321-333 (2020)
University of Florence
Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6.EBI
J Med Chem 63: 295-308 (2020)
University of Pennsylvania
Isolation of three new meroterpenoids and seven known compounds from Albatrellus yasudae and their A?-aggregation inhibitory activity.EBI
Bioorg Med Chem Lett 30: (2020)
Meiji Pharmaceutical University
A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPAEBI
J Med Chem 63: 2372-2390 (2020)
Universidad Complutense de Madrid
Uncarialins A-I, Monoterpenoid Indole Alkaloids from EBI
J Nat Prod 82: 3302-3310 (2019)
Dalian Medical University
Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry.EBI
J Med Chem 63: 2751-2788 (2020)
Purdue University
Discovery of Benzo[EBI
J Med Chem 62: 11080-11107 (2019)
China Pharmaceutical University
Discovery of structurally distinct tricyclic MEBI
Bioorg Med Chem Lett 30: (2020)
Vanderbilt University
Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells.EBI
Bioorg Med Chem 28: (2020)
Heinrich-Heine-Universit£t D£sseldorf
Pyrazolopyrimide library screening in glioma cells discovers highly potent antiproliferative leads that target the PI3K/mTOR pathway.EBI
Bioorg Med Chem 28: (2020)
University of Edinburgh
Tuning isoform selectivity and bortezomib sensitivity with a new class of alkenyl indene PDI inhibitor.EBI
Eur J Med Chem 186: (2020)
Medical University of South Carolina
Discovery of novel 9-heterocyclyl substituted 9H-purines as L858R/T790M/C797S mutant EGFR tyrosine kinase inhibitors.EBI
Eur J Med Chem 186: (2020)
Xi'an Jiaotong University
Conjugable AEBI
Eur J Med Chem 186: (2020)
Universit£ Degli Studi di Trieste
Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints.EBI
Bioorg Med Chem 28: (2020)
Eli Lilly and Company
Structure-based virtual screening and biological evaluation of novel non-bisphosphonate farnesyl pyrophosphate synthase inhibitors.EBI
Eur J Med Chem 186: (2020)
Jiangsu Institute of Nuclear Medicine
Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide MEBI
Bioorg Med Chem Lett 30: (2020)
Vanderbilt University
Design, synthesis, and enzymatic characterization of quinazoline-based CYP1A2 inhibitors.EBI
Bioorg Med Chem Lett 30: (2020)
University of Florida
Development and structure-activity relationship study of SHP2 inhibitor containing 3,4,6-trihydroxy-5-oxo-5H-benzo[7]annulene.EBI
Bioorg Med Chem Lett 30: (2020)
Chungnam University
Further exploration of the structure-activity relationship of imidazoquinolines; identification of potent C7-substituted imidazoquinolines.EBI
Bioorg Med Chem Lett 30: (2020)
University of Kansas
Rational design, synthesis and biological profiling of new KDM4C inhibitors.EBI
Bioorg Med Chem 28: (2020)
Fidelta Ltd.
NO-releasing STAT3 inhibitors suppress BRAF-mutant melanoma growth.EBI
Eur J Med Chem 186: (2020)
The University of Texas at Austin
Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors.EBI
Eur J Med Chem 186: (2020)
University of Firenze
Application of Bivalent Bioisostere Concept on Design and Discovery of Potent Opioid Receptor Modulators.EBI
J Med Chem 62: 11399-11415 (2019)
Virginia Commonwealth University
Synthesis, biological evaluation and SAR studies of ursolic acid 3?-ester derivatives as novel CETP inhibitors.EBI
Bioorg Med Chem Lett 30: (2020)
Nanjing Medical University
Substituted 4-phenylthiazoles: Development of potent and selective AEBI
Eur J Med Chem 186: (2020)
University of Bonn
Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs).EBI
Eur J Med Chem 186: (2020)
Gedeon Richter Plc.
Discovery of a potent and selective adenylyl cyclase type 8 agonist by docking-based virtual screening.EBI
Bioorg Med Chem Lett 30: (2020)
Kunming Medical University
The Druggability of Solute Carriers.EBI
J Med Chem 63: 3834-3867 (2020)
The Scripps Research Institute
Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.EBI
J Nat Prod 82: 3311-3320 (2019)
Osaka University
Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain.EBI
Eur J Med Chem 186: (2020)
University of Toyama
Rational design and Structure-Activity relationship of coumarin derivatives effective on HIV-1 protease and partially on HIV-1 reverse transcriptase.EBI
Eur J Med Chem 186: (2020)
Chinese Academy of Medical Science and Peking Union Medical College
Proline-Based Allosteric Inhibitors of Zika and Dengue Virus NS2B/NS3 Proteases.EBI
J Med Chem 62: 11359-11382 (2019)
Johannes Gutenberg University Mainz
The architecture of hydrogen and sulfur ?-hole interactions explain differences in the inhibitory potency of C-?-d-glucopyranosyl thiazoles, imidazoles and an N-?-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design.EBI
Bioorg Med Chem 28: (2020)
University of Thessaly
Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.EBI
Bioorg Med Chem 28: (2020)
China Pharmaceutical University
Discovery of N-ethylpyridine-2-carboxamide derivatives as a novel scaffold for orally active ?-secretase modulators.EBI
Bioorg Med Chem 28: (2020)
Astellas Pharma Inc.
Structure-activity relationships for binding of 4-substituted triazole-phenols to macrophage migration inhibitory factor (MIF).EBI
Eur J Med Chem 186: (2020)
University of Groningen
Synthesis of Peptoid-Based Class I-Selective Histone Deacetylase Inhibitors with Chemosensitizing Properties.EBI
J Med Chem 62: 11260-11279 (2019)
Heinrich-Heine-Universit£t D£sseldorf
Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors.EBI
Bioorg Med Chem 28: (2020)
Northeastern University
Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.EBI
Bioorg Med Chem Lett 30: (2020)
Bristol-Myers Squibb Research & Development
Synthesis and bioevaluation of 1-phenylimidazole-4-carboxylic acid derivatives as novel xanthine oxidoreductase inhibitors.EBI
Eur J Med Chem 186: (2020)
South China University of Technology
Optimization of cyclic sulfamide derivatives as 11?-hydroxysteroid dehydrogenase 1 inhibitors for the potential treatment of ischemic brain injury.EBI
Bioorg Med Chem Lett 30: (2020)
Korea Research Institute of Chemical Technology
Synthesis and characterization of quinoline-carbaldehyde derivatives as novel inhibitors for leishmanial methionine aminopeptidase 1.EBI
Eur J Med Chem 186: (2020)
University of Hyderabad
Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase.EBI
Bioorg Med Chem 28: (2020)
KU Leuven
Generation of highly potent DYRK1A-dependent inducers of human ?-Cell replication via Multi-Dimensional compound optimization.EBI
Bioorg Med Chem 28: (2020)
Stanford University
Novel compounds that reverse the disease phenotype in Type 2 Gaucher disease patient-derived cells.EBI
Bioorg Med Chem Lett 30: (2020)
Temple University School of Pharmacy
Discovery and optimization of heteroaryl piperazines as potent and selective PI3K? inhibitors.EBI
Bioorg Med Chem Lett 30: (2020)
Merck & Co.
Synthesis of novel 3-halo-3-nitroflavanones and their activities as DNA methyltransferase inhibitors in cancer cells.EBI
Eur J Med Chem 186: (2020)
CNRS FRE3600
Design, synthesis and biological evaluation of new Axl kinase inhibitors containing 1,3,4-oxadiazole acetamide moiety as novel linker.EBI
Eur J Med Chem 186: (2020)
Shenyang Pharmaceutical University
Synthesis, bioconversion, pharmacokinetic and pharmacodynamic evaluation of N-isopropyl-oxy-carbonyloxymethyl prodrugs of CZh-226, a potent and selective PAK4 inhibitor.EBI
Eur J Med Chem 186: (2020)
Shenyang Pharmaceutical University
Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators.EBI
J Med Chem 63: 542-568 (2020)
Northeastern University
Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of ?7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization.EBI
J Med Chem 63: 944-960 (2020)
Lupin Ltd.
Design, synthesis and biological evaluation of imidazole and oxazole fragments as HIV-1 integrase-LEDGF/p75 disruptors and inhibitors of microbial pathogens.EBI
Bioorg Med Chem 28: (2020)
University of the Witwatersrand
Pan-specific and partially selective dye-labeled peptidic inhibitors of the polycomb paralog proteins.EBI
Bioorg Med Chem 28: (2020)
University of Victoria
Design, synthesis and biological evaluation of 8-(2-amino-1-hydroxyethyl)-6-hydroxy-1,4-benzoxazine-3(4H)-one derivatives as potent ?EBI
Bioorg Med Chem 28: (2020)
Shenyang Pharmaceutical University
Design, synthesis and cholinesterase inhibitory activity of novel spiropyrrolidine tethered imidazole heterocyclic hybrids.EBI
Bioorg Med Chem Lett 30: (2020)
King Saud University
Effect of Modifier Structure on the Activation of Leukotriene AEBI
J Med Chem 62: 10605-10616 (2019)
George Mason University
Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model.EBI
ACS Med Chem Lett 10: 1579-1585 (2019)
Goldfinch Bio Inc.
Synthesis and ?-Opioid Activity of the Primary Metabolites of Carfentanil.EBI
ACS Med Chem Lett 10: 1568-1572 (2019)
United States Army CCDC Chemical Biological Center
Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors.EBI
ACS Med Chem Lett 10: 1561-1567 (2019)
Nestl� Skin Health R&D
INCB050465 (Parsaclisib), a Novel Next-Generation Inhibitor of Phosphoinositide 3-Kinase Delta (PI3K?).EBI
ACS Med Chem Lett 10: 1554-1560 (2019)
Incyte Corporation
Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors.EBI
ACS Med Chem Lett 10: 1549-1553 (2019)
Dana-Farber Cancer Institute
Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis.EBI
ACS Med Chem Lett 10: 1543-1548 (2019)
AbbVie, Inc.
Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.EBI
ACS Med Chem Lett 10: 1530-1536 (2019)
Merck & Co., Inc.
Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT).EBI
ACS Med Chem Lett 10: 1524-1529 (2019)
Novartis Institute for Biomedical Research
Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.EBI
ACS Med Chem Lett 10: 1518-1523 (2019)
GlaxoSmithKline
Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein.EBI
J Med Chem 62: 11280-11300 (2019)
TBA
Discovery of Highly Polar ?-Homophenylalanine Derivatives as Nonsystemic Intestine-Targeted Dipeptidyl Peptidase IV Inhibitors.EBI
J Med Chem 62: 10919-10925 (2019)
University of Chinese Academy of Sciences
Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer.EBI
J Med Chem 62: 11301-11323 (2019)
University of Illinois at Chicago
Discovery and Characterization of the Potent and Selective P2X4 Inhibitor EBI
J Med Chem 62: 11194-11217 (2019)
Bayer AG
Discovery of novel nonpeptide small-molecule NRP1 antagonists: Virtual screening, molecular simulation and structural modification.EBI
Bioorg Med Chem 28: (2020)
China Pharmaceutical University
Synthesis, in vitro and in vivo biological evaluation of novel graveolinine derivatives as potential anti-Alzheimer agents.EBI
Bioorg Med Chem 28: (2020)
Henan University
Design, synthesis and biological evaluation of substituted flavones and aurones as potential anti-influenza agents.EBI
Bioorg Med Chem 28: (2020)
Prin. K.M. Kundnani College of Pharmacy
Identification of antimalarial leads with dual falcipain-2 and falcipain-3 inhibitory activity.EBI
Bioorg Med Chem 28: (2020)
Shoolini University of Biotechnology and Management Sciences
Early identification of promiscuous attributes of aldose reductase inhibitors using a DMSO-perturbation assay.EBI
Bioorg Med Chem Lett 30: (2020)
Kyushu University
Design, synthesis and biological evaluation of mogrol derivatives as a novel class of AMPK?2?1?1 activators.EBI
Bioorg Med Chem Lett 30: (2020)
Nanjing University of Chinese Medicine
4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual ?-Opioid Receptor Agonists and ?EBI
J Med Chem 63: 2434-2454 (2020)
ESTEVE Pharmaceuticals SA
Synthesis and Pharmacological Evaluation of Triazolopyrimidinone Derivatives as Noncompetitive, Intracellular Antagonists for CC Chemokine Receptors 2 and 5.EBI
J Med Chem 62: 11035-11053 (2019)
Leiden University
Discovery of 1,2,4-triazine-based derivatives as novel neddylation inhibitors and anticancer activity studies against gastric cancer MGC-803 cells.EBI
Bioorg Med Chem Lett 30: (2020)
Zhengzhou University
PB-10, a thiazolo[4,5-d] pyrimidine derivative, targets p21-activated kinase 4 in human colorectal cancer cells.EBI
Bioorg Med Chem Lett 30: (2020)
Inner Mongolia Medical University
Virtual screening to identify potent sepiapterin reductase inhibitors.EBI
Bioorg Med Chem Lett 30: (2020)
Amgen Inc.
Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity.EBI
Bioorg Med Chem 28: (2020)
Tokyo Institute of Innovative Research
Synthesis of natural product-like polyprenylated phenols and quinones: Evaluation of their neuroprotective activities.EBI
Bioorg Med Chem 28: (2020)
Josai University
Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis.EBI
Eur J Med Chem 186: (2020)
Alexandria University
Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms.EBI
Eur J Med Chem 185: (2020)
Vilnius University
Cerpegin-derived furo[3,4-c]pyridine-3,4(1H,5H)-diones enhance cellular response to interferons by de novo pyrimidine biosynthesis inhibition.EBI
Eur J Med Chem 186: (2020)
Universit£ Paris Descartes
Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents.EBI
Eur J Med Chem 186: (2020)
University of Malakand
Discovery of a Highly Selective and Potent ? Opioid Receptor Agonist from EBI
J Med Chem 62: 11054-11070 (2019)
Fudan University
Subtype Selective ?-Aminobutyric Acid Type A Receptor (GABAEBI
J Med Chem 63: 3425-3446 (2020)
University of Sussex
Psiguadiols A-J, Rearranged Meroterpenoids as Potent PTP1B Inhibitors from EBI
J Nat Prod 82: 3267-3278 (2019)
China Pharmaceutical University
Structure-Based Optimization of Coumarin hAEBI
J Med Chem 63: 2577-2587 (2020)
University of Porto
Alkaloids from the Branches and Leaves of EBI
J Nat Prod 82: 3221-3226 (2019)
Nanjing University of Science and Technology
Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an ?-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere.EBI
J Med Chem 62: 10258-10271 (2019)
TBA
Reasonably activating Nrf2: A long-term, effective and controllable strategy for neurodegenerative diseases.EBI
Eur J Med Chem 185: (2020)
China Pharmaceutical University
Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors.EBI
Eur J Med Chem 185: (2020)
Fudan University
Preliminary SAR and biological evaluation of potent HIV-1 protease inhibitors with pyrimidine bases as novel P2 ligands to enhance activity against DRV-resistant HIV-1 variants.EBI
Eur J Med Chem 185: (2020)
Chinese Academy of Medical Science and Peking Union Medical College
Virtual screening-driven discovery of dual 5-HTEBI
Eur J Med Chem 185: (2020)
Polish Academy of Sciences
Discovery of the programmed cell death-1/programmed cell death-ligand 1 interaction inhibitors bearing an indoline scaffold.EBI
Eur J Med Chem 186: (2020)
Shenyang Pharmaceutical University
Hydroxyl substituted benzoic acid/cinnamic acid derivatives: Tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies.EBI
Bioorg Med Chem Lett 30: (2020)
The University of Queensland (UQ)
Identification of neomacrophorins isolated from Trichoderma sp. 1212-03 as proteasome inhibitors.EBI
Bioorg Med Chem 27: (2019)
Iwate University
Discovery of covalent prolyl oligopeptidase boronic ester inhibitors.EBI
Eur J Med Chem 185: (2020)
McGill University
Discovery of candesartan cilexetic as a novel neddylation inhibitor for suppressing tumor growth.EBI
Eur J Med Chem 185: (2020)
Shanghai University of Traditional Chinese Medicine
Targeting CXCR1/2: The medicinal potential as cancer immunotherapy agents, antagonists research highlights and challenges ahead.EBI
Eur J Med Chem 185: (2020)
Hangzhou Institute of Innovative Medicine
Synthesis, biological evaluation, and docking study of indole aryl sulfonamides as aromatase inhibitors.EBI
Eur J Med Chem 185: (2020)
"G. d'Annunzio" University
Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader.EBI
J Med Chem 62: 10897-10911 (2019)
Icahn School of Medicine at Mount Sinai
Multitarget CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach ?.EBI
J Med Chem 62: 10833-10847 (2019)
Universit£ degli Studi di Parma
Structure-Based and Property-Driven Optimization of EBI
J Med Chem 62: 10816-10832 (2019)
Global Discovery Chemistry
Indole-based melatonin analogues: Synthetic approaches and biological activity.EBI
Eur J Med Chem 185: (2020)
Nantong University
Targeting Aryl hydrocarbon receptor for next-generation immunotherapies: Selective modulators (SAhRMs) versus rapidly metabolized ligands (RMAhRLs).EBI
Eur J Med Chem 185: (2020)
University of Perugia
Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2YEBI
Eur J Med Chem 186: (2020)
University of Bonn
Synthesis and elaboration of N-methylpyrrolidone as an acetamide fragment substitute in bromodomain inhibition.EBI
Bioorg Med Chem 27: (2019)
Monash University (Parkville Campus)
Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells.EBI
J Med Chem 62: 10867-10896 (2019)
Tsinghua University
Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72.EBI
J Med Chem 62: 11383-11398 (2019)
The Institute of Cancer Research
Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor EBI
J Med Chem 62: 11119-11134 (2019)
Merck Healthcare
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.EBI
J Med Chem 62: 11232-11259 (2019)
Vanderbilt University
Biphenyl Acid Derivatives as APJ Receptor Agonists.EBI
J Med Chem 62: 10456-10465 (2019)
Bristol-Myers Squibb
New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine HEBI
J Med Chem 62: 11416-11422 (2019)
Universit£ Bourgogne Franche-Comt£
Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for Nicotinamide EBI
J Med Chem 62: 10783-10797 (2019)
TBA
An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights.EBI
J Med Chem 63: 2391-2410 (2020)
University of Bonn
Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia.EBI
J Med Chem 62: 11135-11150 (2019)
National Health Research Institutes
Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3EBI
J Med Chem 63: 512-528 (2020)
Sanofi
Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors.EBI
Eur J Med Chem 185: (2020)
Egyptian Russian University
Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer.EBI
J Nat Prod 82: 3065-3073 (2019)
Soochow University
Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.EBI
J Med Chem 62: 10676-10690 (2019)
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences and Gilead Sciences Research Centre at IOCB
Ligand-Based Design of Nondimethylphenyl-Diarylpyrimidines with Improved Metabolic Stability, Safety, and Oral Pharmacokinetic Profiles.EBI
J Med Chem 62: 11430-11436 (2019)
Fudan University
Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines.EBI
J Med Chem 63: 1261-1280 (2020)
Universit£ degli Studi di Parma
Optimization Strategy of Novel Peptide-Based Michael Acceptors for the Treatment of Human African Trypanosomiasis.EBI
J Med Chem 62: 10617-10629 (2019)
University of Messina
Promiscuity of in Vitro Secondary Pharmacology Assays and Implications for Lead Optimization Strategies.EBI
J Med Chem 63: 6251-6275 (2020)
AstraZeneca
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.EBI
Eur J Med Chem 185: (2020)
University of Porto
Design, synthesis and evaluation of 2-amino-imidazol-4-one derivatives as potent ?-site amyloid precursor protein cleaving enzyme 1 (BACE-1) inhibitors.EBI
Bioorg Med Chem Lett 29: (2019)
Nanjing University of Chinese Medicine
Exploration of zinc-binding groups for the design of inhibitors for the oxytocinase subfamily of M1 aminopeptidases.EBI
Bioorg Med Chem 27: (2019)
National Centre for Scientific Research "Demokritos"
Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC).EBI
J Med Chem 62: 11004-11018 (2019)
AstraZeneca
Novel Benzohydroxamate-Based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis, and Biological Evaluation.EBI
J Med Chem 62: 10711-10739 (2019)
Preclinical R&D
Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate.EBI
J Med Chem 62: 10563-10582 (2019)
Lupin Ltd.
Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors.EBI
J Med Chem 62: 10740-10756 (2019)
TBA
Discovery of potent and selective butyrylcholinesterase inhibitors through the use of pharmacophore-based screening.EBI
Bioorg Med Chem Lett 29: (2019)
University of Kentucky
Discovery of [1,2,4]-triazolo [1,5-a]pyrimidine-7(4H)-one derivatives as positive modulators of GABAEBI
Eur J Med Chem 185: (2020)
Qingdao University of Science and Technology
Design, synthesis and biological evaluation of oseltamivir derivatives containing pyridyl group as potent inhibitors of neuraminidase for influenza A.EBI
Eur J Med Chem 185: (2020)
Wuyi University
A new chemotype with promise against Trypanosoma cruzi.EBI
Bioorg Med Chem Lett 30: (2020)
University of Nebraska Medical Center
Selective apoptosis-inducing activity of synthetic hydrocarbon-stapled SOS1 helix with d-amino acids in H358 cancer cells expressing KRASEBI
Eur J Med Chem 185: (2020)
China Pharmaceutical University
Design, synthesis, and evaluation of compounds capable of reducing Pseudomonas aeruginosa virulence.EBI
Eur J Med Chem 185: (2020)
Texas Tech University Health Sciences Center
Discovery of small-molecule candidates against inflammatory bowel disease.EBI
Eur J Med Chem 185: (2020)
Zhejiang University
Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic.EBI
J Med Chem 63: 418-424 (2020)
Seoul National University
Optimizing Targeted Inhibitors of P-Glycoprotein Using Computational and Structure-Guided Approaches.EBI
J Med Chem 62: 10645-10663 (2019)
TBA
Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors.EBI
J Med Chem 62: 10757-10782 (2019)
Johann Wolfgang Goethe-University
Structure-based analysis and biological characterization of imatinib derivatives reveal insights towards the inhibition of wild-type BCR-ABL and its mutants.EBI
Bioorg Med Chem Lett 29: (2019)
Peking Union Medical College and Chinese Academy of Medical Sciences
An isoform-selective inhibitor of tropomyosin receptor kinase A behaves as molecular glue.EBI
Bioorg Med Chem Lett 30: (2020)
Osaka Prefecture University
Synthesis and antidepressant-like activity of novel alkoxy-piperidine derivatives targeting SSRI/5-HTEBI
Bioorg Med Chem Lett 29: (2019)
China Pharmaceutical University
Novel benzimidazole phosphonates as potential inhibitors of protein prenylation.EBI
Bioorg Med Chem Lett 29: (2019)
University of Iowa
Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases.EBI
Eur J Med Chem 185: (2020)
Shandong University
Direct and straightforward access to substituted alkyl selenols as novel carbonic anhydrase inhibitors.EBI
Eur J Med Chem 185: (2020)
University of Florence
Development of Robust 17(EBI
J Med Chem 62: 10124-10143 (2019)
University of Texas Southwestern
Discovery of 4EBI
J Med Chem 62: 10691-10710 (2019)
TBA
A New Approach of Mitigating CYP3A4 Induction Led to the Discovery of Potent Hepatitis B Virus (HBV) Capsid Inhibitor with Optimal ADMET Profiles.EBI
J Med Chem 62: 10352-10361 (2019)
TBA
Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.EBI
J Med Chem 62: 10272-10293 (2019)
Boehringer Ingelheim RCV GmbH & Co KG
Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors EBI
J Med Chem 62: 10221-10244 (2019)
University of Colorado Boulder
6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum.EBI
Bioorg Med Chem 27: (2019)
National Science and Technology Development Agency
Design, synthesis and 3D-QSAR analysis of novel thiopyranopyrimidine derivatives as potential antitumor agents inhibiting A549 and Hela cancer cells.EBI
Eur J Med Chem 185: (2020)
Jiangxi Science & Technology Normal University
Nitrothiadiazolo[3,2-a]pyrimidines as promising antiglycating agents.EBI
Eur J Med Chem 185: (2020)
Ural Federal University Named After the First President of Russia B.N. Eltsin
Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability.EBI
J Med Chem 63: 6547-6560 (2020)
TBA
Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors.EBI
J Med Chem 63: 2731-2750 (2020)
Dana-Farber Cancer Institute
Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor ? and inhibition of de novo purine nucleotide biosynthesis.EBI
Bioorg Med Chem 27: (2019)
Duquesne University
Design, synthesis and biological evaluation of novel desloratadine derivatives with anti-inflammatory and HEBI
Bioorg Med Chem Lett 29: (2019)
China Pharmaceutical University
6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease.EBI
Bioorg Med Chem Lett 29: (2019)
University of Wollongong
Identification of a new small molecule chemotype of Melanin Concentrating Hormone Receptor-1 antagonists using pharmacophore-based virtual screening.EBI
Bioorg Med Chem Lett 29: (2019)
University of Science and Technology
Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease.EBI
Bioorg Med Chem Lett 29: (2019)
Janssen Research & Development, LLC
Synthesis and biological evaluation of new MET inhibitors with 1,6-naphthyridinone scaffold.EBI
Eur J Med Chem 185: (2020)
Central China Normal University
Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity.EBI
Bioorg Med Chem Lett 29: (2019)
Daiichi Sankyo Co., Ltd.
Multigram scale synthesis of polycyclic lactones and evaluation of antitumor and other biological properties.EBI
Eur J Med Chem 185: (2020)
Universitat de Barcelona
6-Methyluracil derivatives as peripheral site ligand-hydroxamic acid conjugates: Reactivation for paraoxon-inhibited acetylcholinesterase.EBI
Eur J Med Chem 185: (2020)
Kazan Scientific Center of the Russian Academy of Sciences
Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer.EBI
J Med Chem 62: 10182-10203 (2019)
Colorado State University
4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine HEBI
J Med Chem 62: 10848-10866 (2019)
Vrije Universiteit Amsterdam
Synthesis, Pharmacological Characterization, and Structure-Activity Relationships of Noncanonical Selective Agonists for ?7 nAChRs.EBI
J Med Chem 62: 10376-10390 (2019)
University of California-San Diego
Flavipesines A and B and Asperchalasines E-H: Cytochalasans and Merocytochalasans from EBI
J Nat Prod 82: 2994-3001 (2019)
Huazhong University of Science and Technology
The identification and pharmacological evaluation of potent, selective and orally available ACC1 inhibitor.EBI
Bioorg Med Chem Lett 29: (2019)
Takeda Pharmaceutical Company Limited
The Immunoproteasome: An Emerging Target in Cancer and Autoimmune and Neurological Disorders.EBI
J Med Chem 63: 1841-1858 (2020)
Purdue University
Discovery of Potent and Orally Effective Dual Janus Kinase 2/FLT3 Inhibitors for the Treatment of Acute Myelogenous Leukemia and Myeloproliferative Neoplasms.EBI
J Med Chem 62: 10305-10320 (2019)
West China Hospital of Sichuan University
Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo.EBI
J Med Chem 62: 10321-10341 (2019)
Bayer AG
Could Dissecting the Molecular Framework of ?-Lactam Integrin Ligands Enhance Selectivity?EBI
J Med Chem 62: 10156-10166 (2019)
University of Bologna
A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model.EBI
Eur J Med Chem 185: (2020)
Korea Institute of Science and Technology (KIST)
Search for new multi-target compounds against Alzheimer's disease among histamine HEBI
Eur J Med Chem 185: (2020)
Jagiellonian University Medical College
Discovery of arylamide-5-anilinoquinazoline-8-nitro derivatives as VEGFR-2 kinase inhibitors: Synthesis, in vitro biological evaluation and molecular docking.EBI
Bioorg Med Chem Lett 29: (2019)
Yunnan University
An anthrone-based Kv7.2/7.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders.EBI
Bioorg Med Chem Lett 29: (2019)
Marquette University
Glechomanamides A-C, Germacrane Sesquiterpenoids with an Unusual ?EBI
J Nat Prod 82: 3056-3064 (2019)
Seoul National University
Sugar Kick Prevents Memory Impairment.EBI
J Med Chem 62: 10059-10061 (2019)
TBA
Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain.EBI
J Med Chem 62: 10144-10155 (2019)
University of Toronto
Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions.EBI
J Med Chem 63: 1798-1822 (2020)
China Pharmaceutical University
?-Lactamase Inhibitors To Restore the Efficacy of Antibiotics against Superbugs.EBI
J Med Chem 63: 1859-1881 (2020)
Universidade de Santiago de Compostela
Validation of Human Sterol 14?-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors.EBI
J Med Chem 62: 10391-10401 (2019)
Vanderbilt University School of Medicine
Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability.EBI
J Med Chem 63: 2343-2357 (2020)
National Institute on Drug Abuse-Intramural Research Program
Fibrinolysis Inhibitors: Potential Drugs for the Treatment and Prevention of Bleeding.EBI
J Med Chem 63: 1445-1472 (2020)
Philipps University Marburg
Structure-Activity Relationship Studies of Small Molecule Modulators of the Staphylococcal Accessory Gene Regulator.EBI
J Med Chem 63: 2705-2730 (2020)
Veterans Affairs Eastern Colorado Health Care System
Enhancing the Cell Permeability of Stapled Peptides with a Cyclic Cell-Penetrating Peptide.EBI
J Med Chem 62: 10098-10107 (2019)
The Ohio State University
N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-? induced PD-L1 expression.EBI
Eur J Med Chem 185: (2020)
Taipei Medical University
Optimization of pyrrolizine-based Schiff bases with 4-thiazolidinone motif: Design, synthesis and investigation of cytotoxicity and anti-inflammatory potency.EBI
Eur J Med Chem 185: (2020)
Umm Al-Qura University
From bench to counter: Discovery and validation of a peony extract as tyrosinase inhibiting cosmeceutical.EBI
Eur J Med Chem 184: (2019)
University of Innsbruck
Design, synthesis and biological evaluation of benzoylacrylic acid shikonin ester derivatives as irreversible dual inhibitors of tubulin and EGFR.EBI
Bioorg Med Chem 27: (2019)
Nanjing University
Impact of hydroxy moieties at the benzo[7]annulene ring system of GluN2B ligands: Design, synthesis and biological evaluation.EBI
Bioorg Med Chem 27: (2019)
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster
Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors.EBI
Bioorg Med Chem 27: (2019)
Tanta University
Overcoming imatinib resistance in chronic myelogenous leukemia cells using non-cytotoxic cell death modulators.EBI
Eur J Med Chem 185: (2020)
University of Innsbruck
Free-Wilson Analysis of Comprehensive Data on Phosphoinositide-3-kinase (PI3K) Inhibitors Reveals Importance of EBI
J Med Chem 62: 10402-10422 (2019)
University of Nottingham
Kinase Chemodiversity from the Arctic: The Breitfussins.EBI
J Med Chem 62: 10167-10181 (2019)
UiT - The Arctic University of Norway
Differentiating the Pharmacodynamics and Toxicology of Macrolide and Ketolide Antibiotics.EBI
J Med Chem 63: 6462-6473 (2020)
Ponce De Leon Health
Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers.EBI
Bioorg Med Chem Lett 29: (2019)
Ural Branch of Russian Academy of Sciences
Development and Therapeutic Potential of Selenazo Compounds.EBI
J Med Chem 63: 1473-1489 (2020)
Universidad de Navarra
Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity.EBI
J Med Chem 62: 10204-10220 (2019)
Daiichi Sankyo Co., Ltd.
Rationally Designed, Conformationally Constrained Inverse Agonists of ROR?t-Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy.EBI
J Med Chem 62: 9931-9946 (2019)
Bristol-Myers Squibb
Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies.EBI
Bioorg Med Chem Lett 29: (2019)
Merck Healthcare
Strategies for Late-Stage Optimization: Profiling Thermodynamics by Preorganization and Salt Bridge Shielding.EBI
J Med Chem 62: 9753-9771 (2019)
Philipps-Universit£t Marburg
Engineering Fluorine into Verticillins (Epipolythiodioxopiperazine Alkaloids) via Precursor-Directed Biosynthesis.EBI
J Nat Prod 82: 3104-3110 (2019)
University of North Carolina at Greensboro
One-pot synthesis of novel tert-butyl-4-substituted phenyl-1H-1,2,3-triazolo piperazine/piperidine carboxylates, potential GPR119 agonists.EBI
Bioorg Med Chem Lett 29: (2019)
Koneru Lakshmaiah Education Foundation
Optimization of the chromone scaffold through QSAR and docking studies: Identification of potent inhibitors of ABCG2.EBI
Eur J Med Chem 184: (2019)
Univ. Grenoble Alpes
Synthesis and structure activity relationship of 1, 3-benzo-thiazine-2-thiones as selective HDAC8 inhibitors.EBI
Eur J Med Chem 184: (2019)
University of Applied Sciences
Synthetic strategy and SAR studies of C-glucoside heteroaryls as SGLT2 inhibitor: A review.EBI
Eur J Med Chem 184: (2019)
Jamia Hamdard
Novel berberine-based derivatives with potent hypoglycemic activity.EBI
Bioorg Med Chem Lett 29: (2019)
Guizhou Medical University
Design, synthesis, and biological evaluation of 4-phenoxyquinoline derivatives as potent c-Met kinase inhibitor.EBI
Bioorg Med Chem Lett 29: (2019)
Shenyang Pharmaceutical University
Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology.EBI
Bioorg Med Chem 27: (2019)
Northeastern University
3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights.EBI
Eur J Med Chem 184: (2019)
Egyptian Russian University
Benzo[b]thiophene-thiazoles as potent anti-Toxoplasma gondii agents: Design, synthesis, tyrosinase/tyrosine hydroxylase inhibitors, molecular docking study, and antioxidant activity.EBI
Eur J Med Chem 184: (2019)
Nicolaus Copernicus University
Structure-based design and SAR development of novel selective polo-like kinase 1 inhibitors having the tetrahydropteridin scaffold.EBI
Eur J Med Chem 184: (2019)
Hefei University of Technology
Synthesis and antidepressant effect of novel aralkyl piperazine and piperidine derivatives targeting SSRI/5-HTEBI
Bioorg Med Chem Lett 29: (2019)
China State Institute of Pharmaceutical Industry
Design, synthesis and biological evaluation of curcumin analogues as novel LSD1 inhibitors.EBI
Bioorg Med Chem Lett 29: (2019)
Shenyang Pharmaceutical University
Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor.EBI
Eur J Med Chem 184: (2019)
National University of Singapore
Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase.EBI
J Med Chem 62: 9703-9717 (2019)
University of Warwick
Discovery of Second-Generation NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization.EBI
J Med Chem 62: 9718-9731 (2019)
TBA
Synthesis, Purification, and Selective ?EBI
J Nat Prod 82: 2986-2993 (2019)
Shandong University
Trivirensols: Selectively Bacteriostatic Sesquiterpene Trimers from the Australian Termite Nest-Derived Fungus EBI
J Nat Prod 82: 3165-3175 (2019)
The University of Queensland
Synthesis and biological evaluation of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives as potential MERS-CoV inhibitors.EBI
Bioorg Med Chem Lett 29: (2019)
Korea Research Institute of Chemical Technology
Developing new hybrid scaffold for urease inhibition based on carbazole-chalcone conjugates: Synthesis, assessment of therapeutic potential and computational docking analysis.EBI
Bioorg Med Chem 27: (2019)
Quaid-i-Azam University
Development of a novel class of peroxisome proliferator-activated receptor (PPAR) gamma ligands as an anticancer agent with a unique binding mode based on a non-thiazolidinedione scaffold.EBI
Bioorg Med Chem 27: (2019)
Hokkaido University
Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors.EBI
Eur J Med Chem 184: (2019)
Shanghai Institute of Materia Medica
Discovery of a Series of 5-Azaquinazolines as Orally Efficacious IRAK4 Inhibitors Targeting MyD88EBI
J Med Chem 62: 9918-9930 (2019)
AstraZeneca
Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives.EBI
J Med Chem 63: 1490-1510 (2020)
Fudan University
Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry.EBI
ACS Med Chem Lett 10: 1492-1497 (2019)
AstraZeneca
Discovery of Pyridazinone and Pyrazolo[1,5-EBI
ACS Med Chem Lett 10: 1486-1491 (2019)
Bristol-Myers Squibb Company
Scaffold Morphing To Identify Novel DprE1 Inhibitors with Antimycobacterial Activity.EBI
ACS Med Chem Lett 10: 1480-1485 (2019)
AstraZeneca
Preclinical Development of PQR514, a Highly Potent PI3K Inhibitor Bearing a Difluoromethyl-Pyrimidine Moiety.EBI
ACS Med Chem Lett 10: 1473-1479 (2019)
University of Basel
Design of Potent and Selective Covalent Inhibitors of Bruton's Tyrosine Kinase Targeting an Inactive Conformation.EBI
ACS Med Chem Lett 10: 1467-1472 (2019)
Novartis Institutes for BioMedical Research
Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold.EBI
ACS Med Chem Lett 10: 1443-1449 (2019)
Dana Farber Cancer Institute
3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HTEBI
ACS Med Chem Lett 10: 1436-1442 (2019)
University of Minnesota Twin Cities
Novel Pyrazole-Containing Compounds Active against EBI
ACS Med Chem Lett 10: 1423-1429 (2019)
Sapienza University of Rome
Chalcone-Thiazole Hybrids: Rational Design, Synthesis, and Lead Identification against 5-Lipoxygenase.EBI
ACS Med Chem Lett 10: 1415-1422 (2019)
Indian Institute of Technology
Pyridinylimidazoles as GSK3? Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks.EBI
ACS Med Chem Lett 10: 1407-1414 (2019)
Eberhard Karls Universit£t T£bingen
Lysophosphatidic Acid Receptor 1 Antagonists for the Treatment of Fibrosis.EBI
ACS Med Chem Lett 10: 1378-1379 (2019)
Therachem Research Medilab, LLC
Inhibitors of KRAS May Potentially Provide Effective Cancer Treatment.EBI
ACS Med Chem Lett 10: 1376-1377 (2019)
Therachem Research Medilab, LLC.
Second-Generation FGFR Inhibitors for the Treatment of Cancers Harboring Mutated FGFRs.EBI
ACS Med Chem Lett 10: 1374-1375 (2019)
Therachem Research Medilab, LLC.
PROTAC-Mediated Degradation of Estrogen Receptor in the Treatment of Cancer.EBI
ACS Med Chem Lett 10: 1367-1369 (2019)
Usona Institute
Structure-Activity Relationships of EBI
J Med Chem 62: 9792-9805 (2019)
University of Melbourne
Protein Tyrosine Phosphatase 1B Inhibitory Iridoids from EBI
J Nat Prod 82: 2916-2924 (2019)
University of Illinois at Chicago
Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies.EBI
J Nat Prod 82: 2768-2779 (2019)
European Biomedical Research Institute of Salerno (EBRIS)
Structure-Activity Relationships of Fish Oil Derivatives with Antiallergic Activity in Vitro and in Vivo.EBI
J Med Chem 62: 9576-9592 (2019)
Ehime University
In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds.EBI
J Med Chem 63: 6477-6488 (2020)
Case Western Reserve University
Oleanolic Acid Derivatives as Potential Inhibitors of HIV-1 Protease.EBI
J Nat Prod 82: 2886-2896 (2019)
TBA
Discovery and development of extreme selective inhibitors of the ITD and D835Y mutant FLT3 kinases.EBI
Eur J Med Chem 184: (2019)
Vichem Chemie Research Ltd
Benzyl Phenylsemicarbazides: A Chemistry-Driven Approach Leading to G Protein-Biased Dopamine DEBI
J Med Chem 62: 9658-9679 (2019)
Friedrich-Alexander-Universit£t Erlangen-N£rnberg
Lead identification and characterization of hTrkA type 2 inhibitors.EBI
Bioorg Med Chem Lett 29: (2019)
Zoetis Inc
Discovery of novel inhibitors of phosphodiesterase 4 with 1-phenyl-3,4-dihydroisoquinoline scaffold: Structure-based drug design and fragment identification.EBI
Bioorg Med Chem Lett 29: (2019)
South China Agricultural University
Structure-activity relationship study of NPP1 inhibitors based on uracil-N1-(methoxy)ethyl-?-phosphate scaffold.EBI
Eur J Med Chem 184: (2019)
Bar-Ilan University
Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors.EBI
Eur J Med Chem 184: (2019)
China Pharmaceutical University
Design, synthesis, and biological evaluation of 1-substituted -2-aryl imidazoles targeting tubulin polymerization as potential anticancer agents.EBI
Eur J Med Chem 184: (2019)
Southern Medical University
Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases.EBI
J Med Chem 62: 9045-9060 (2019)
TBA
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo.EBI
J Med Chem 62: 9078-9102 (2019)
Julius Maximilian University of W£rzburg
Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model.EBI
J Med Chem 62: 9116-9140 (2019)
Julius Maximilian University W£rzburg
Discovery and optimization of covalent Bcl-xL antagonists.EBI
Bioorg Med Chem Lett 29: (2019)
AstraZeneca
Anti-hepatitis-C virus activity and QSAR study of certain thiazolidinone and thiazolotriazine derivatives as potential NS5B polymerase inhibitors.EBI
Eur J Med Chem 184: (2019)
Cairo University
Development and Characterization of a Fluorescent Probe for GLS1 and the Application for High-Throughput Screening of Allosteric Inhibitors.EBI
J Med Chem 62: 9642-9657 (2019)
China Pharmaceutical University
Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-EBI
J Med Chem 63: 2547-2556 (2020)
University of Oxford
Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1.EBI
J Med Chem 62: 9890-9905 (2019)
University Medicine Greifswald
Synthesis and Pharmacological Evaluation of 1-Phenyl-3-Thiophenylurea Derivatives as Cannabinoid Type-1 Receptor Allosteric Modulators.EBI
J Med Chem 62: 9806-9823 (2019)
Research Triangle Institute
Design, Synthesis, and Pharmacological Evaluation of Potent Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor (GLP-1R).EBI
J Med Chem 63: 2292-2307 (2020)
Sanofi-Aventis Deutschland GmbH
Design, synthesis, and evaluation of potent novel peroxisome proliferator-activated receptor ? indole partial agonists.EBI
Bioorg Med Chem Lett 29: (2019)
The University of Oklahoma Health Science Center
Discovery of novel allosteric site and covalent inhibitors of FBPase with potent hypoglycemic effects.EBI
Eur J Med Chem 184: (2019)
International Cooperation Base of Pesticide and Green Synthesis (Hubei)
High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide EBI
J Med Chem 62: 9837-9873 (2019)
BioKin Ltd.
Protein Stability Effects in Aggregate-Based Enzyme Inhibition.EBI
J Med Chem 62: 9593-9599 (2019)
University of California
Discovery of AM-6494: A Potent and Orally Efficacious ?-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2.EBI
J Med Chem 63: 2263-2281 (2020)
TBA
Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect.EBI
Eur J Med Chem 183: (2019)
Medical University of Warsaw
Novel virosecurinine bivalent mimetics as potent reversal agents against P-glycoprotein-mediated multidrug resistance.EBI
Eur J Med Chem 183: (2019)
Jinan University
Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancer.EBI
Eur J Med Chem 183: (2019)
Ain Shams University
The discovery of a potent and selective third-generation EGFR kinase inhibitor as a therapy for EGFR L858R/T790M double mutant non-small cell lung cancer.EBI
Eur J Med Chem 183: (2019)
Sun Yat-sen University
Structure-activity relationships of serotonin 5-HTEBI
Eur J Med Chem 183: (2019)
Normandie Univ
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.EBI
Eur J Med Chem 183: (2019)
Chinese Academy of Sciences
Hot-Spots of Mcl-1 Protein.EBI
J Med Chem 63: 928-943 (2020)
Normandie Univiversit�
Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine DEBI
J Med Chem 62: 9488-9520 (2019)
University of Nottingham
-Benzyl/Aryl Substituted Tryptanthrin as Dual Inhibitors of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase.EBI
J Med Chem 62: 9161-9174 (2019)
Fudan University
Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3.EBI
J Med Chem 62: 9874-9889 (2019)
Pharmaxis Ltd
Novel tertiary sulfonamide derivatives containing benzimidazole moiety as potent anti-gastric cancer agents: Design, synthesis and SAR studies.EBI
Eur J Med Chem 183: (2019)
Zhengzhou University
Chirality-Driven Mode of Binding of ?-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).EBI
J Med Chem 62: 9691-9702 (2019)
McGill University
Recent Developments in Therapeutic Peptides for the Glucagon-like Peptide 1 and 2 Receptors.EBI
J Med Chem 63: 905-927 (2020)
Sosei Heptares
Bipolaricins A-I, Ophiobolin-Type Tetracyclic Sesterterpenes from a Phytopathogenic EBI
J Nat Prod 82: 2897-2906 (2019)
Huazhong University of Science and Technology
Discovery of 2-aminopyridines bearing a pyridone moiety as potent ALK inhibitors to overcome the crizotinib-resistant mutants.EBI
Eur J Med Chem 183: (2019)
Zhejiang University
Development of Chemical Entities Endowed with Potent Fast-Killing Properties against EBI
J Med Chem 62: 9217-9235 (2019)
GlaxoSmithKline
Divalent cannabinoid-1 receptor ligands: A linker attachment point survey of SR141716A for development of high-affinity CB1R molecular probes.EBI
Bioorg Med Chem Lett 29: (2019)
University of Auckland
Discovery of novel, potent, isosteviol-based antithrombotic agents.EBI
Eur J Med Chem 183: (2019)
Peking University
Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25.EBI
Eur J Med Chem 183: (2019)
Montana State University
Ellagic acid a multi-target bioactive compound for drug discovery in CNS? A narrative review.EBI
Eur J Med Chem 183: (2019)
University of Genoa
Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement.EBI
Bioorg Med Chem 27: (2019)
Universidade de S£o Paulo
Recent advances in class IIa histone deacetylases research.EBI
Bioorg Med Chem 27: (2019)
Heinrich-Heine-Universit£t D£sseldorf
Discovery of new small molecule inhibitors targeting isocitrate dehydrogenase 1 (IDH1) with blood-brain barrier penetration.EBI
Eur J Med Chem 183: (2019)
Chinese Academy of Sciences
Design and development of molecular hybrids of 2-pyridylpiperazine and 5-phenyl-1,3,4-oxadiazoles as potential multifunctional agents to treat Alzheimer's disease.EBI
Eur J Med Chem 183: (2019)
Indian Institute of Technology (Banaras Hindu University)
Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders.EBI
J Med Chem 62: 9471-9487 (2019)
TBA
Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer.EBI
J Med Chem 62: 10108-10123 (2019)
National Health Research Institutes
Selective Phenylimidazole-Based Inhibitors of the EBI
J Med Chem 62: 9246-9253 (2019)
Weill Cornell Medicine
Dihydroorotate dehydrogenase inhibitors in anti-infective drug research.EBI
Eur J Med Chem 183: (2019)
University of Turin (UniTo)
Design, synthesis and biological evaluation of N-(3-(1H-tetrazol-1-yl)phenyl)isonicotinamide derivatives as novel xanthine oxidase inhibitors.EBI
Eur J Med Chem 183: (2019)
China Medical University
Insights on the synthesis of asymmetric curcumin derivatives and their biological activities.EBI
Eur J Med Chem 183: (2019)
Universiti Kuala Lumpur
Trifluorinated Pyrimidine-Based AEBI
J Med Chem 62: 9315-9330 (2019)
Uppsala University
Discovery of Novel Aryl Carboxamide Derivatives as Hypoxia-Inducible Factor 1? Signaling Inhibitors with Potent Activities of Anticancer Metastasis.EBI
J Med Chem 62: 9299-9314 (2019)
Anhui Medical University
Anti-biofilm Agents against EBI
J Med Chem 62: 9201-9216 (2019)
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
Progress in the development of more effective and safer analgesics for pain management.EBI
Eur J Med Chem 183: (2019)
University of Catania
Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors.EBI
Eur J Med Chem 183: (2019)
University of Catania
Design, synthesis and biological evaluation of novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potential FAK inhibitors and anticancer agents.EBI
Eur J Med Chem 183: (2019)
Shenyang Pharmaceutical University
A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function.EBI
J Med Chem 62: 9008-9025 (2019)
University of Oxford
Aryl-fluorosulfate-based Lysine Covalent Pan-Inhibitors of Apoptosis Protein (IAP) Antagonists with Cellular Efficacy.EBI
J Med Chem 62: 9188-9200 (2019)
TBA
The Exploration of Chirality for Improved Druggability within the Human Kinome.EBI
J Med Chem 63: 441-469 (2020)
University of Arkansas for Medical Sciences
p97: An Emerging Target for Cancer, Neurodegenerative Diseases, and Viral Infections.EBI
J Med Chem 63: 1892-1907 (2020)
TBA
Discovery of an Extremely Potent Thiazine-Based ?-Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose.EBI
J Med Chem 62: 9331-9337 (2019)
TBA
Drugs for the Treatment of Zika Virus Infection.EBI
J Med Chem 63: 470-489 (2020)
University of North Carolina at Chapel Hill
Structure optimization of a new class of PPAR? antagonists.EBI
Bioorg Med Chem 27: (2019)
Fraunhofer Institute for Molecular Biology and Applied Ecology IME
Design, synthesis and biological evaluation of novel serotonin and dopamine receptor ligands being 6-bromohexyl saccharine derivatives.EBI
Bioorg Med Chem Lett 29: (2019)
Cracow University of Technology
1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships.EBI
Eur J Med Chem 183: (2019)
Guizhou University of Traditional Chinese Medicine
Rational discovery of a highly novel and selective mTOR inhibitor.EBI
Bioorg Med Chem Lett 29: (2019)
Takeda California
Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies.EBI
Eur J Med Chem 183: (2019)
Bezmialem Vakif University
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics.EBI
Eur J Med Chem 183: (2019)
University of Modena and Reggio Emilia
Design and synthesis of (2-(phenylamino)thieno[3,2-d]pyrimidin-4-yl)(3,4,5-trimethoxyphenyl)methanone analogues as potent anti-tubulin polymerization agents.EBI
Eur J Med Chem 183: (2019)
Peking University
Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries.EBI
Eur J Med Chem 183: (2019)
Shandong University
Polygala tenuifolia-Acori tatarinowii herbal pair as an inspiration for substituted cinnamic ?-asaronol esters: Design, synthesis, anticonvulsant activity, and inhibition of lactate dehydrogenase study.EBI
Eur J Med Chem 183: (2019)
Northwest University
New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies.EBI
Eur J Med Chem 183: (2019)
Cairo University
Continued exploration and tail approach synthesis of benzenesulfonamides containing triazole and dual triazole moieties as carbonic anhydrase I, II, IV and IX inhibitors.EBI
Eur J Med Chem 183: (2019)
Kurukshetra University
Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and EBI
J Med Chem 62: 9026-9044 (2019)
The University of Jordan
Design, synthesis and evaluation of activity and pharmacokinetic profile of new derivatives of xanthone and piperazine in the central nervous system.EBI
Bioorg Med Chem Lett 29: (2019)
Jagiellonian University Medical College
Discovery of a novel 3,4-dimethylcinnoline carboxamide MEBI
Bioorg Med Chem Lett 29: (2019)
Vanderbilt University
1,3,4-Oxadiazol-2-ylbenzenesulfonamides as privileged structures for the inhibition of monoamine oxidase B.EBI
Bioorg Med Chem Lett 29: (2019)
Ushinsky Yaroslavl State Pedagogical University
Indole: A privileged scaffold for the design of anti-cancer agents.EBI
Eur J Med Chem 183: (2019)
Hunan University of Science and Technology
Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors.EBI
Eur J Med Chem 183: (2019)
Yale University
Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation.EBI
Eur J Med Chem 183: (2019)
The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences
Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study.EBI
Eur J Med Chem 183: (2019)
Minia University
SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease.EBI
J Med Chem 62: 9438-9449 (2019)
University of California
Discovery of GSK3527497: A Candidate for the Inhibition of Transient Receptor Potential Vanilloid-4 (TRPV4).EBI
J Med Chem 62: 9270-9280 (2019)
GlaxoSmithKline
Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1EBI
J Med Chem 62: 8711-8732 (2019)
AMRI UK Ltd
Development of High-Throughput Fluorescent-Based Screens to Accelerate Discovery of P2X Inhibitors from Animal Venoms.EBI
J Nat Prod 82: 2559-2567 (2019)
University of East Anglia
Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge EBI
J Nat Prod 82: 2586-2593 (2019)
Shanghai Jiao Tong University
?-Fluorofentanyls Are pH-Sensitive Mu Opioid Receptor Agonists.EBI
ACS Med Chem Lett 10: 1353-1356 (2019)
Marquette University
A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences.EBI
ACS Med Chem Lett 10: 1346-1352 (2019)
Goethe-University Frankfurt
Photoswitchable Inhibitor of the Calcium Channel TRPV6.EBI
ACS Med Chem Lett 10: 1341-1345 (2019)
University of Bern
Fluorinated Analogues of the Histone Deacetylase Inhibitor Vorinostat (Zolinza): Validation of a Chiral Hybrid Bioisostere, BITE.EBI
ACS Med Chem Lett 10: 1336-1340 (2019)
University of Munster
Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.EBI
ACS Med Chem Lett 10: 1322-1327 (2019)
AstraZeneca
Discovery of EBI
ACS Med Chem Lett 10: 1302-1308 (2019)
Amgen Inc.
Systematically Mitigating the p38? Activity of Triazole-based BET Inhibitors.EBI
ACS Med Chem Lett 10: 1296-1301 (2019)
University of Minnesota Twin Cities
Synthesis and Bioactivity of the Alanyl Phosphonamidate Stereoisomers Derived from a Butyrophilin Ligand.EBI
ACS Med Chem Lett 10: 1284-1289 (2019)
University of Iowa
Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.EBI
ACS Med Chem Lett 10: 1266-1271 (2019)
Universidade Estadual de Campinas (UNICAMP)
Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1).EBI
ACS Med Chem Lett 10: 1260-1265 (2019)
Genentech
PROTAC Degradation of IRAK4 for the Treatment of Neurodegenerative and Cardiovascular Diseases.EBI
ACS Med Chem Lett 10: 1251-1252 (2019)
Usona Institute
Triazolo Pyridines Useful as Inhibitors of ?-Secretase and Their Methods of Use.EBI
ACS Med Chem Lett 10: 1249-1250 (2019)
Temple University School of Pharmacy
Sodium Channel Modulators and Their Method of Use.EBI
ACS Med Chem Lett 10: 1247-1248 (2019)
Temple University School of Pharmacy
Modulators of KEAP-1 Activity as Potential Therapies for the Treatment of Neurodegenerative Disorders.EBI
ACS Med Chem Lett 10: 1245-1246 (2019)
Temple University School of Pharmacy
Triazolo-azepine Inhibitors of ?-Secretase and Their Methods of Use.EBI
ACS Med Chem Lett 10: 1243-1244 (2019)
Temple University School of Pharmacy
[1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HTEBI
Eur J Med Chem 183: (2019)
Universit£ di Catania
Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application.EBI
Bioorg Med Chem Lett 29: (2019)
Takeda Pharmaceutical Company Limited
Investigation of Novel Primary and Secondary Pharmacophores and 3-Substitution in the Linking Chain of a Series of Highly Selective and Bitopic Dopamine DEBI
J Med Chem 62: 9061-9077 (2019)
National Institute on Drug Abuse-Intramural Research Program
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaEBI
J Med Chem 62: 9618-9641 (2019)
Xenon Pharmaceuticals Inc.
Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo.EBI
J Med Chem 63: 2229-2239 (2020)
University of Auckland
Pyroglutamide-Based P2X7 Receptor Antagonists Targeting Inflammatory Bowel Disease.EBI
J Med Chem 63: 2074-2094 (2020)
Universit£ de Lille
Inhibition Mechanisms of Indoleamine 2,3-Dioxygenase 1 (IDO1).EBI
J Med Chem 62: 8784-8795 (2019)
SIB Swiss Institute of Bioinformatics
Antibacterial activity of 2-amino-4-hydroxypyrimidine-5-carboxylates and binding to Burkholderia pseudomallei 2-C-methyl-d-erythritol-2,4-cyclodiphosphate synthase.EBI
Bioorg Med Chem Lett 29: (2019)
Northern Illinois University
Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.EBI
Bioorg Med Chem Lett 29: (2019)
GlaxoSmithKline
The discovery and optimization of a series of 2-aminobenzoxazole derivatives as ChemR23 inhibitors.EBI
Bioorg Med Chem 27: (2019)
Kyowa Kirin Co., Ltd.
Synthesis and biological evaluation of calycanthaceous alkaloid analogs.EBI
Bioorg Med Chem 27: (2019)
Jiangsu University of Science and Technology
Immunoproteasome-selective inhibitors: An overview of recent developments as potential drugs for hematologic malignancies and autoimmune diseases.EBI
Eur J Med Chem 182: (2019)
Hangzhou Xixi Hospital
Discovery of a potent p38?/MAPK14 kinase inhibitor: Synthesis, in vitro/in vivo biological evaluation, and docking studies.EBI
Eur J Med Chem 183: (2019)
University of Sharjah
C-terminal modulators of heat shock protein of 90?kDa (HSP90): State of development and modes of action.EBI
Bioorg Med Chem 27: (2019)
Heinrich Heine University D£sseldorf
Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes.EBI
Bioorg Med Chem Lett 29: (2019)
Janssen Research & Development, L.L.C.
Benzothiazole-based compounds as potent endothelial lipase inhibitors.EBI
Bioorg Med Chem Lett 29: (2019)
Bristol-Myers Squibb
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems.EBI
Eur J Med Chem 183: (2019)
University of Siena
The Rise of Molecules Able To Regenerate the Central Nervous System.EBI
J Med Chem 63: 490-511 (2020)
Universit£ Grenoble Alpes
Synthesis and exploration of 2-morpholino-4-phenylthiazol-5-yl acrylamide derivatives for their effects against carbonic anhydrase I, II, IX and XII isoforms as a non-sulfonamide class of inhibitors.EBI
Bioorg Med Chem 27: (2019)
National Institute of Pharmaceutical Education and Research (NIPER)
Highly hydrophilic 1,3-oxazol-5-yl benzenesulfonamide inhibitors of carbonic anhydrase II for reduction of glaucoma-related intraocular pressure.EBI
Bioorg Med Chem 27: (2019)
Saint Petersburg State University
Recent advances in the development of cyclin-dependent kinase 7 inhibitors.EBI
Eur J Med Chem 183: (2019)
Tianjin University of Science and Technology
Synthesis of benzotriazoles derivatives and their dual potential as ?-amylase and ?-glucosidase inhibitors in vitro: Structure-activity relationship, molecular docking, and kinetic studies.EBI
Eur J Med Chem 183: (2019)
University of Karachi
Activity of 2,6,9-trisubstituted purines as potent PDGFR? kinase inhibitors with antileukaemic activity.EBI
Eur J Med Chem 182: (2019)
Palack£ University and Institute of Experimental Botany
Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2).EBI
Eur J Med Chem 182: (2019)
University of Manchester
Identification of a Unique Resorcylic Acid Lactone Derivative That Targets Both Lymphangiogenesis and Angiogenesis.EBI
J Med Chem 62: 9141-9160 (2019)
Korea University
Design and Biological Evaluation of EBI
J Med Chem 62: 8773-8783 (2019)
Shenyang Pharmaceutical University
Targeting the ?-Aminobutyric Acid Type B (GABAEBI
J Med Chem 62: 8819-8830 (2019)
University of Copenhagen
Potential Tools for Eradicating HIV Reservoirs in the Brain: Development of Trojan Horse Prodrugs for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity.EBI
J Med Chem 63: 2131-2138 (2020)
Purdue University
A fluorine scan on the ZnEBI
Eur J Med Chem 182: (2019)
Fudan University
Discovery and synthesis of 3- and 21-substituted fusidic acid derivatives as reversal agents of P-glycoprotein-mediated multidrug resistance.EBI
Eur J Med Chem 182: (2019)
Yantai University
Structural Characterization of Agonist Binding to an AEBI
J Med Chem 62: 8831-8846 (2019)
National and Kapodistrian University of Athens
Recent advances in the targeting of human DNA ligase I as a potential new strategy for cancer treatment.EBI
Eur J Med Chem 182: (2019)
University of Allahabad
Design, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in vitro and in vivo.EBI
Eur J Med Chem 182: (2019)
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
14- and 15-membered lactone macrolides and their analogues and hybrids: structure, molecular mechanism of action and biological activity.EBI
Eur J Med Chem 182: (2019)
Adam Mickiewicz University
Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists.EBI
J Med Chem 62: 8631-8641 (2019)
Eisai Co., Ltd.
Designing around Structural Alerts in Drug Discovery.EBI
J Med Chem 63: 6276-6302 (2020)
Pfizer Inc.
Discovery of an Orally Bioavailable Pan ?v Integrin Inhibitor for Idiopathic Pulmonary Fibrosis.EBI
J Med Chem 62: 8796-8808 (2019)
GlaxoSmithKline Medicines Research Centre
Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from EBI
J Med Chem 62: 8733-8759 (2019)
University of Freiburg
In vitro cytotoxicity screening to identify novel anti-osteosarcoma therapeutics targeting pyruvate dehydrogenase kinase 2.EBI
Bioorg Med Chem Lett 29: (2019)
Capital Medical University
Natural products as important tyrosine kinase inhibitors.EBI
Eur J Med Chem 182: (2019)
Southwest Jiaotong University
Natural dimers of coumarin, chalcones, and resveratrol and the link between structure and pharmacology.EBI
Eur J Med Chem 182: (2019)
Nagasaki International University
Highly potent non-steroidal FXR agonists protostane-type triterpenoids: Structure-activity relationship and mechanism.EBI
Eur J Med Chem 182: (2019)
Dalian Medical University
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers.EBI
Eur J Med Chem 182: (2019)
University of Florence
Identification and characterization of benzo[d]oxazol-2(3H)-one derivatives as the first potent and selective small-molecule inhibitors of chromodomain protein CDYL.EBI
Eur J Med Chem 182: (2019)
Peking University
Synthesis, biological evaluation and molecular docking of 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety.EBI
Bioorg Med Chem 27: (2019)
Luoyang Normal University
Recent advancements in mechanistic studies and structure activity relationship of FEBI
Eur J Med Chem 182: (2019)
Kurukshetra University
Novel N-Substituted oseltamivir derivatives as potent influenza neuraminidase inhibitors: Design, synthesis, biological evaluation, ADME prediction and molecular docking studies.EBI
Eur J Med Chem 182: (2019)
The Hong Kong Polytechnic University
Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors.EBI
Eur J Med Chem 182: (2019)
Anadolu University
Synthesis, biological activities, and docking studies of d-pantolactone derivatives as novel FAS inhibitors.EBI
Bioorg Med Chem 27: (2019)
Third Institute of Oceanography
An exploration of solvent-front region high affinity moiety leading to novel potent ALK & ROS1 dual inhibitors with mutant-combating effects.EBI
Bioorg Med Chem 27: (2019)
Shenyang Pharmaceutical University
Discovery of novel steroidal histamine HEBI
Bioorg Med Chem Lett 29: (2019)
Chemical Works of Gedeon Richter Plc
Structure-Based Discovery and Development of a Series of Potent and Selective Bromodomain and Extra-Terminal Protein Inhibitors.EBI
J Med Chem 62: 8642-8663 (2019)
University of Chinese Academy of Sciences
Novel promising 4-anilinoquinazoline-based derivatives as multi-target RTKs inhibitors: Design, molecular docking, synthesis, and antitumor activities in vitro and vivo.EBI
Bioorg Med Chem 27: (2019)
Beijing Normal University
Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors.EBI
Bioorg Med Chem 27: (2019)
Universitat de Barcelona
Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies.EBI
J Med Chem 62: 10062-10097 (2019)
Merck & Co.
Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening.EBI
J Med Chem 62: 8809-8818 (2019)
Okayama University Graduate School of Medicine
Neurobehavioral investigation and acetylcholinesterase inhibitory activity study for some new coumarin derivatives.EBI
Eur J Med Chem 182: (2019)
Cairo University
Cyclin dependent kinase (CDK) inhibitors as anticancer drugs: Recent advances (2015-2019).EBI
Bioorg Med Chem Lett 29: (2019)
Eli Lilly and Company
From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction.EBI
Eur J Med Chem 182: (2019)
Saint Petersburg State University
GAC inhibitors with a 4-hydroxypiperidine spacer: Requirements for potency.EBI
Bioorg Med Chem Lett 29: (2019)
University of Pittsburgh
?-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors.EBI
Bioorg Med Chem Lett 29: (2019)
University of Iowa
Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain.EBI
Eur J Med Chem 182: (2019)
Seoul National University
Structure-activity relationship with pyrazoline-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: Synthesis and biological evaluation.EBI
Eur J Med Chem 182: (2019)
University of Cagliari
Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.EBI
Bioorg Med Chem Lett 29: (2019)
LifeArc
Novel lipid side chain modified exenatide analogs emerged prolonged glucoregulatory activity and potential body weight management properties.EBI
Bioorg Med Chem 27: (2019)
China Pharmaceutical University
Novel thiazolidines: Synthesis, antiproliferative properties and 2D-QSAR studies.EBI
Bioorg Med Chem 27: (2019)
University of Texas-Arlington
Identification of Novel Resorcinol Amide Derivatives as Potent and Specific Pyruvate Dehydrogenase Kinase (PDHK) Inhibitors.EBI
J Med Chem 62: 8461-8479 (2019)
Korea University
Indole-Diterpenoids with Protein Tyrosine Phosphatase Inhibitory Activities from the Marine-Derived Fungus EBI
J Nat Prod 82: 2638-2644 (2019)
Hebei University
[EBI
J Med Chem 62: 8338-8356 (2019)
University of Regensburg
Optimization and anti-inflammatory evaluation of methyl gallate derivatives as a myeloid differentiation protein 2 inhibitor.EBI
Bioorg Med Chem 27: (2019)
Wenzhou Medical University
Design, synthesis, and biological evaluation of 4-((6,7-dimethoxyquinoline-4-yl)oxy)aniline derivatives as FLT3 inhibitors for the treatment of acute myeloid leukemia.EBI
Bioorg Med Chem Lett 29: (2019)
Shenyang Pharmaceutical University
Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.EBI
J Med Chem 62: 8578-8608 (2019)
Hong Kong Polytechnic University
Myxochelin- and Pseudochelin-Derived Lipoxygenase Inhibitors from a Genetically Engineered EBI
J Nat Prod 82: 2544-2549 (2019)
Institute for Natural Product Research and Infection Biology e.V.
A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor.EBI
J Med Chem 62: 8609-8630 (2019)
University of Basel
Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins.EBI
Eur J Med Chem 182: (2019)
University of Chinese Academy of Sciences
Myrmenaphthol A, Isolated from a Hawaiian Sponge of the Genus EBI
J Nat Prod 82: 2668-2671 (2019)
University of Hawaii at Manoa
Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-?-Lactamases.EBI
J Med Chem 62: 8544-8556 (2019)
University of Oxford
Antioxidant-Conjugated 1,2,4-Triazolo[4,3-EBI
J Med Chem 62: 8511-8531 (2019)
Universit£ degli Studi di Firenze
Glycocluster Tetrahydroxamic Acids Exhibiting Unprecedented Inhibition of EBI
J Med Chem 62: 7722-7738 (2019)
CNRS-Universit£ de Picardie Jules Verne
A rational search for discovering potential neutraligands of human complement fragment 5a (EBI
Bioorg Med Chem 27: (2019)
Indian Institute of Technology Bhubaneswar
Structural tuning of acridones for developing anticancer agents targeting dihydrofolate reductase.EBI
Bioorg Med Chem Lett 29: (2019)
Guru Nanak Dev University
Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates bearing sulfonylpiperazine as antitumor inhibitors targeting PI3K?.EBI
Eur J Med Chem 182: (2019)
School of Traditional Chinese Pharmacy
Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.EBI
Bioorg Med Chem Lett 29: (2019)
Bristol-Myers Squibb Company
Synthesis and characterization of novel isoform-selective IP6K1 inhibitors.EBI
Bioorg Med Chem Lett 29: (2019)
Johns Hopkins University School of Medicine
Discovery of potent p38? MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation.EBI
Eur J Med Chem 182: (2019)
University of Perugia
Cyclic enaminone as new chemotype for selective cyclooxygenase-2 inhibitory, anti-inflammatory, and analgesic activities.EBI
Eur J Med Chem 182: (2019)
National Institute of Pharmaceutical Education and Research (NIPER)
Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HTEBI
Eur J Med Chem 182: (2019)
University of Illinois at Chicago
Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer.EBI
Eur J Med Chem 182: (2019)
Nanjing Medical University
Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis.EBI
Eur J Med Chem 182: (2019)
The University of Queensland
Pyrazolo-benzothiazole hybrids: Synthesis, anticancer properties and evaluation of antiangiogenic activity using in vitro VEGFR-2 kinase and in vivo transgenic zebrafish model.EBI
Eur J Med Chem 182: (2019)
Academy of Scientific and Innovative Research (AcSIR)
Type 2 inhibitor leads of human tropomyosin receptor kinase (hTrkA).EBI
Bioorg Med Chem Lett 29: (2019)
Zoetis
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.EBI
Bioorg Med Chem Lett 29: (2019)
Guizhou Medical University
Discovery of novel functionalized 1,2,4-triazoles as PARP-1 inhibitors in breast cancer: Design, synthesis and antitumor activity evaluation.EBI
Eur J Med Chem 182: (2019)
Suez Canal University
Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity.EBI
Eur J Med Chem 182: (2019)
University of Cagliari
Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-EBI
J Med Chem 62: 7788-7805 (2019)
Singapore-MIT Alliance for Research and Technology
Design, synthesis and biological evaluation of benzamide derivatives as novel NTCP inhibitors that induce apoptosis in HepG2 cells.EBI
Bioorg Med Chem Lett 29: (2019)
Southwest Jiaotong University
Discovery of novel series of 2-substituted benzo[d]oxazol-5-amine derivatives as multi-target directed ligands for the treatment of Alzheimer's disease.EBI
Eur J Med Chem 182: (2019)
Indian Institute of Technology (Banaras Hindu University)
Structure Kinetics Relationships and Molecular Dynamics Show Crucial Role for Heterocycle Leaving Group in Irreversible Diacylglycerol Lipase Inhibitors.EBI
J Med Chem 62: 7910-7922 (2019)
Leiden University
Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain.EBI
J Med Chem 62: 8443-8460 (2019)
Goethe-University Frankfurt
Synthesis and biological evaluation of 4-(piperid-3-yl)amino substituted 6-pyridylquinazolines as potent PI3K? inhibitors.EBI
Bioorg Med Chem 27: (2019)
Xi'an Jiaotong University
Discovery of fused heterocyclic carboxamide derivatives as novel ?7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation.EBI
Eur J Med Chem 182: (2019)
Peking University
Synthesis, structure-activity relationship and trypanocidal activity of pyrazole-imidazoline and new pyrazole-tetrahydropyrimidine hybrids as promising chemotherapeutic agents for Chagas disease.EBI
Eur J Med Chem 182: (2019)
Instituto Oswaldo Cruz
Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing.EBI
Eur J Med Chem 182: (2019)
Shandong University
Cholinesterase Inhibitory Arisugacins L-Q from a EBI
J Nat Prod 82: 2627-2637 (2019)
Institute for Natural Products Applications and Research Technologies
Correlation of indoleamine-2,3-dioxigenase 1 inhibitory activity of 4,6-disubstituted indazole derivatives and their heme binding affinity.EBI
Bioorg Med Chem Lett 29: (2019)
Osaka University
Novel ?,?-unsaturated hydroxamic acid derivatives overcome cisplatin resistance.EBI
Bioorg Med Chem 27: (2019)
Heinrich-Heine-University D£sseldorf
Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells.EBI
J Nat Prod 82: 2443-2450 (2019)
Siberian Branch of the Russian Academy of Sciences
2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth.EBI
J Med Chem 63: 2308-2324 (2020)
University of Manchester
Labdanes, Withanolides, and Other Constituents from EBI
J Nat Prod 82: 2489-2500 (2019)
Universidad Nacional Aut£noma de M£xico
Lead Optimization Yields High Affinity Frizzled 7-Targeting Peptides That Modulate EBI
J Med Chem 62: 7739-7750 (2019)
TBA
Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold.EBI
Bioorg Med Chem 27: (2019)
Universit£ di Siena
Discovery of aryl-substituted indole and indoline derivatives as ROR?t agonists.EBI
Eur J Med Chem 182: (2019)
Fudan University
How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using EBI
J Med Chem 63: 2095-2113 (2020)
Johannes Gutenberg-Universit£t Mainz
Galloyl esters of trans-stilbenes are inhibitors of FASN with anticancer activity on non-small cell lung cancer cells.EBI
Eur J Med Chem 182: (2019)
National University of Singapore
Synthesis and in vitro evaluation of piperazinyl-ureido sulfamates as steroid sulfatase inhibitors.EBI
Eur J Med Chem 182: (2019)
University of Cagliari
Design, synthesis and biological evaluation of 3,5-dimethylisoxazole and pyridone derivatives as BRD4 inhibitors.EBI
Bioorg Med Chem Lett 29: (2019)
Sichuan University
Rasagiline derivatives combined with histamine HEBI
Bioorg Med Chem Lett 29: (2019)
Heinrich Heine University D£sseldorf
Conformational restriction design of thiophene-biphenyl-DAPY HIV-1 non-nucleoside reverse transcriptase inhibitors.EBI
Eur J Med Chem 182: (2019)
Fudan University
Hitting on the move: Targeting intrinsically disordered protein states of the MDM2-p53 interaction.EBI
Eur J Med Chem 182: (2019)
University of Groningen
Discovery of small molecule inhibitors of human uridine-cytidine kinase 2 by high-throughput screening.EBI
Bioorg Med Chem Lett 29: 2559-2564 (2019)
Stanford University
Fluorescent analogs of peptoid-based HDAC inhibitors: Synthesis, biological activity and cellular uptake kinetics.EBI
Bioorg Med Chem 27: (2019)
Leipzig University
Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor.EBI
Bioorg Med Chem 27: (2019)
Fudan University
Discovery and development of substituted thiadiazoles as inhibitors of Staphylococcus aureus Sortase A.EBI
Bioorg Med Chem 27: (2019)
University of Gothenburg
STING modulators: Predictive significance in drug discovery.EBI
Eur J Med Chem 182: (2019)
Zhejiang Normal University
Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells.EBI
Eur J Med Chem 182: (2019)
University of Florence
Novel multi target-directed ligands targeting 5-HTEBI
Eur J Med Chem 182: (2019)
Normandie Univ
Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design.EBI
J Med Chem 62: 11022-11034 (2019)
Emory University School of Medicine
First Nondiscriminating Translocator Protein Ligands Produced from a Carbazole Scaffold.EBI
J Med Chem 62: 8235-8248 (2019)
Macquarie University
Drug Discovery Targeting Anaplastic Lymphoma Kinase (ALK).EBI
J Med Chem 62: 10927-10954 (2019)
Zhejiang University
Synthesis and Evaluation of Novel TLR2 Agonists as Potential Adjuvants for Cancer Vaccines.EBI
J Med Chem 63: 2282-2291 (2020)
University of Auckland
Lowering Lipophilicity by Adding Carbon: AzaSpiroHeptanes, a logEBI
ACS Med Chem Lett 10: 1198-1204 (2019)
AstraZeneca
Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase C? (PKC?) That Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis.EBI
ACS Med Chem Lett 10: 1134-1139 (2019)
Vertex Pharmaceuticals Inc
Design, Synthesis and Anticancer Evaluation of New Substituted Thiophene-Quinoline Derivatives.EBI
Bioorg Med Chem 27: (2019)
Kyushu Institute of Technology1-1 Sensuicho
Synthesis, molecular docking, and QSAR study of bis-sulfonamide derivatives as potential aromatase inhibitors.EBI
Bioorg Med Chem 27: (2019)
Srinakharinwirot University
Design and evaluation of pyrazolopyrimidines as KCNQ channel modulators.EBI
Bioorg Med Chem Lett 29: (2019)
AbbVie Inc.
Potent HIV-1 protease inhibitors incorporating squaramide-derived P2 ligands: Design, synthesis, and biological evaluation.EBI
Bioorg Med Chem Lett 29: 2565-2570 (2019)
Purdue University
Design of selective PI3K? inhibitors using an iterative scaffold-hopping workflow.EBI
Bioorg Med Chem Lett 29: 2575-2580 (2019)
Merck & Co.
Discovery of ?-sultone-fused pyrazoles for treating Alzheimer's disease: Design, synthesis, biological evaluation and SAR studies.EBI
Eur J Med Chem 181: (2019)
Anhui Medical University
Design, synthesis and preliminary bioactivity evaluations of 8-hydroxyquinoline derivatives as matrix metalloproteinase (MMP) inhibitors.EBI
Eur J Med Chem 181: (2019)
Shandong University
Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1EBI
J Med Chem 62: 7769-7787 (2019)
Orexo AB
Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases.EBI
J Med Chem 63: 23-39 (2020)
University of Naples Federico II
Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase.EBI
J Med Chem 62: 7669-7683 (2019)
Pfizer Inc.
Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models.EBI
J Med Chem 62: 8557-8577 (2019)
University of Illinois at Chicago
Iterative Optimization of the Cyclic Peptide SFTI-1 Yields Potent Inhibitors of Neutrophil Proteinase 3.EBI
ACS Med Chem Lett 10: 1234-1239 (2019)
The University of Queensland
Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4).EBI
ACS Med Chem Lett 10: 1228-1233 (2019)
GlaxoSmithKline
DPP1 Inhibitors: Exploring the Role of Water in the S2 Pocket of DPP1 with Substituted Pyrrolidines.EBI
ACS Med Chem Lett 10: 1222-1227 (2019)
AstraZeneca
Identification of CB1 Receptor Allosteric Sites Using Force-Biased MMC Simulated Annealing and Validation by Structure-Activity Relationship Studies.EBI
ACS Med Chem Lett 10: 1216-1221 (2019)
University of North Carolina at Greensboro
Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors.EBI
ACS Med Chem Lett 10: 1205-1210 (2019)
Universit£ de Montpellier
Design of a Long-Acting and Selective MEG-Fatty Acid Stapled Prolactin-Releasing Peptide Analog.EBI
ACS Med Chem Lett 10: 1166-1172 (2019)
Calibr at Scripps Research
Evaluation of a Series of ?-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads.EBI
ACS Med Chem Lett 10: 1159-1165 (2019)
Janssen Research & Development
Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice.EBI
ACS Med Chem Lett 10: 1154-1158 (2019)
Hokkaido University
Successful Strategies for Mitigation of a Preclinical Signal for Phototoxicity in a DGAT1 Inhibitor.EBI
ACS Med Chem Lett 10: 1128-1133 (2019)
Novartis Institutes for Biomedical Research
Design, Synthesis, and Biological Evaluation of 2,4-Imidazolinedione Derivatives as HDAC6 Isoform-Selective Inhibitors.EBI
ACS Med Chem Lett 10: 1122-1127 (2019)
Shandong University
Prodrug Activation by a Viral Protease: Evaluating Combretastatin Peptide Hybrids To Selectively Target Infected Cells.EBI
ACS Med Chem Lett 10: 1115-1121 (2019)
Heidelberg University
Inhibition of ACSS2 for Treatment of Cancer and Neuropsychiatric Diseases.EBI
ACS Med Chem Lett 10: 1100-1101 (2019)
Usona Institute
In Praise of Remarkably Powerful Centamolecular Therapeutic Agents.EBI
ACS Med Chem Lett 10: 1094-1097 (2019)
Bristol-Myers Squibb Research and Development
Discovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer's Agents by Structure-Based Design.EBI
J Med Chem 62: 8011-8027 (2019)
Seoul National University
A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity.EBI
J Med Chem 62: 8028-8052 (2019)
University of Copenhagen
Discovery of 4-piperazinyl-2-aminopyrimidine derivatives as dual inhibitors of JAK2 and FLT3.EBI
Eur J Med Chem 181: (2019)
Shenyang Pharmaceutical University
Identification of benzothiazinones containing an oxime functional moiety as new anti-tuberculosis agents.EBI
Eur J Med Chem 181: (2019)
Chinese Academy of Medical Sciences and Peking Union Medical College
Discovery of EBI
J Med Chem 62: 8164-8177 (2019)
New England Discovery Partners
Colocalization Strategy Unveils an Underside Binding Site in the Transmembrane Domain of Smoothened Receptor.EBI
J Med Chem 62: 9983-9989 (2019)
ShanghaiTech University
Germacrane Sesquiterpenoids as a New Type of Anticardiac Fibrosis Agent Targeting Transforming Growth Factor ? Type I Receptor.EBI
J Med Chem 62: 7961-7975 (2019)
Sun Yat-Sen University
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation.EBI
J Med Chem 62: 10995-11003 (2019)
Universit£ degli Studi di Bari "Aldo Moro"
Coumarin-containing hybrids and their anticancer activities.EBI
Eur J Med Chem 181: (2019)
Tsinghua University
Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases.EBI
Eur J Med Chem 181: (2019)
Palack£ University
Development of novel theranostic agents for in vivo amyloid imaging and protective effects on human neuroblastoma cells.EBI
Eur J Med Chem 181: (2019)
Guangdong University of Technology
Homotrimerization Approach in the Design of Thrombospondin-1 Mimetic Peptides with Improved Potency in Triggering Regulated Cell Death of Cancer Cells.EBI
J Med Chem 62: 7656-7668 (2019)
Sorbonne Universit£
Synthetic routes and structure-activity relationships (SAR) of anti-HIV agents: A key review.EBI
Eur J Med Chem 181: (2019)
Wuhan University of Technology
Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity.EBI
Eur J Med Chem 181: (2019)
University of Florence
Phenolic N-monosubstituted carbamates: Antitubercular and toxicity evaluation of multi-targeting compounds.EBI
Eur J Med Chem 181: (2019)
Charles University
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.EBI
Eur J Med Chem 180: 690-706 (2019)
Julius Maximilian University of W£rzburg
Synthesis and biological activity of structurally diverse phthalazine derivatives: A systematic review.EBI
Bioorg Med Chem 27: 3979-3997 (2019)
Y. B. Chavan College of Pharmacy
Discovery of 1,8-disubstituted-[1,2,3]triazolo[4,5-c]quinoline derivatives as a new class of Hippo signaling pathway inhibitors.EBI
Bioorg Med Chem Lett 29: 2595-2603 (2019)
Sichuan University
Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.EBI
Bioorg Med Chem Lett 29: 2638-2645 (2019)
Qingdao University
Exploring hydroxamic acid inhibitors of HDAC1 and HDAC2 using small molecule tools and molecular or homology modelling.EBI
Bioorg Med Chem Lett 29: 2581-2586 (2019)
The University of Sydney
Small molecule modulators targeting protein kinase CK1 and CK2.EBI
Eur J Med Chem 181: (2019)
China Pharmaceutical University
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group.EBI
Eur J Med Chem 181: (2019)
Universit£ del Piemonte Orientale
Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy.EBI
Eur J Med Chem 181: (2019)
University of Belgrade
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors.EBI
Eur J Med Chem 181: (2019)
Universit£ di Ferrara
Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines.EBI
Eur J Med Chem 181: (2019)
University of Siena
Discovery of benzimidazole analogs as a novel interleukin-5 inhibitors.EBI
Eur J Med Chem 181: (2019)
Chungnam National University
A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification.EBI
J Med Chem 62: 7506-7525 (2019)
Cellzome
Structure-activity analysis of peptidic Chlamydia HtrA inhibitors.EBI
Bioorg Med Chem 27: 4185-4199 (2019)
University of Otago
Design, synthesis and biological evaluation of novel dithiocarbamate-substituted diphenylaminopyrimidine derivatives as BTK inhibitors.EBI
Bioorg Med Chem 27: 4124-4142 (2019)
Peking University Health Science Center
New anthranilic acid-incorporating N-benzenesulfonamidophthalimides as potent inhibitors of carbonic anhydrases I, II, IX, and XII: Synthesis, in vitro testing, and in silico assessment.EBI
Eur J Med Chem 181: (2019)
King Saud University
Integrated Synthetic, Biophysical, and Computational Investigations of Covalent Inhibitors of Prolyl Oligopeptidase and Fibroblast Activation Protein ?.EBI
J Med Chem 62: 7874-7884 (2019)
McGill University
Bioactivatable Pseudotripeptidization of Cyclic Dipeptides To Increase the Affinity toward Oligopeptide Transporter 1 for Enhanced Oral Absorption: An Application to Cyclo(l-Hyp-l-Ser) (JBP485).EBI
J Med Chem 62: 7708-7721 (2019)
Dalian Medical University
Neuroactive Steroid EBI
J Med Chem 62: 7526-7542 (2019)
SAGE Therapeutics
Discovery of ?-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.EBI
J Med Chem 62: 8357-8363 (2019)
Sanford Burnham Prebys Medical Discovery Institute
Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands.EBI
J Med Chem 62: 8152-8163 (2019)
TBA
4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation.EBI
J Med Chem 62: 8330-8337 (2019)
TBA
Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine DEBI
Bioorg Med Chem Lett 29: 2690-2694 (2019)
Temple University School of Pharmacy
Design, synthesis and biological evaluation of novel 4-anilinoquinazoline derivatives as hypoxia-selective EGFR and VEGFR-2 dual inhibitors.EBI
Eur J Med Chem 181: (2019)
Peking Union Medical College & Chinese Academy of Medical Sciences
A computer-assisted discovery of novel potential anti-obesity compounds as selective carbonic anhydrase VA inhibitors.EBI
Eur J Med Chem 181: (2019)
"Magna Gr£cia" University of Catanzaro
HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope.EBI
J Med Chem 62: 8062-8079 (2019)
University of Massachusetts Medical School
Synthesis and SAR Study of Carbamoyl Pyridone Bicycle Derivatives as Potent Inhibitors of Influenza Cap-dependent Endonuclease.EBI
J Med Chem 62: 8101-8114 (2019)
Shionogi & Company
The Development Process for Discovery and Clinical Advancement of Modern Antimalarials.EBI
J Med Chem 62: 10526-10562 (2019)
The Walter and Eliza Hall Institute of Medical Research
11-Aminostrychnine and EBI
J Nat Prod 82: 2332-2336 (2019)
The German University in Cairo
Preparation and biological evaluation of soluble tetrapeptide epoxyketone proteasome inhibitors.EBI
Bioorg Med Chem 27: 4151-4162 (2019)
Nanjing Forestry University
Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability.EBI
Bioorg Med Chem 27: 4163-4173 (2019)
Jagiellonian University Medical College
Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity.EBI
Bioorg Med Chem Lett 29: 2686-2689 (2019)
California Institute of Technology
Discovery of novel PTHR1 antagonists: Design, synthesis, and structure activity relationships.EBI
Bioorg Med Chem Lett 29: 2613-2616 (2019)
Daiichi Sankyo Co, Ltd
Novel dual inhibitors targeting CDK4 and VEGFR2 synergistically suppressed cancer progression and angiogenesis.EBI
Eur J Med Chem 181: (2019)
Nankai University
Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity.EBI
Eur J Med Chem 181: (2019)
Heinrich Heine University D£sseldorf
Synthesis, biological evaluation, and docking studies of new raloxifene sulfonate or sulfamate derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase.EBI
Eur J Med Chem 181: (2019)
University of Sharjah
Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity.EBI
J Med Chem 62: 7897-7909 (2019)
Merck Healthcare KGaA
Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.EBI
J Med Chem 62: 7923-7940 (2019)
TBA
Profile of a Highly Selective Quaternized Pyrrolidine Betaine ?EBI
J Med Chem 62: 7543-7556 (2019)
GlaxoSmithKline Medicines Research Centre
Discovery of Inhibitors of Aurora/PLK Targets as Anticancer Agents.EBI
J Med Chem 62: 7697-7707 (2019)
Chengdu University
Microwave-Assisted Organic Synthesis, structure-activity relationship, kinetics and molecular docking studies of non-cytotoxic benzamide derivatives as selective butyrylcholinesterase inhibitors.EBI
Bioorg Med Chem 27: 4030-4040 (2019)
University of Karachi
Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2).EBI
Bioorg Med Chem 27: 4013-4029 (2019)
Vrije Universiteit Amsterdam
Applications of amide isosteres in medicinal chemistry.EBI
Bioorg Med Chem Lett 29: 2535-2550 (2019)
Xenon Pharmaceuticals Inc
Targeting the subpocket in xanthine oxidase: Design, synthesis, and biological evaluation of 2-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives.EBI
Eur J Med Chem 181: (2019)
Shenyang Pharmaceutical University
Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.EBI
Eur J Med Chem 181: (2019)
Nankai University
Cinnamamide: An insight into the pharmacological advances and structure-activity relationships.EBI
Eur J Med Chem 181: (2019)
National Institute of Pharmaceutical Education and Research (NIPER)
Design, synthesis and anti-inflammatory evaluation of 3-amide benzoic acid derivatives as novel P2YEBI
Eur J Med Chem 181: (2019)
China Pharmaceutical University
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.EBI
Eur J Med Chem 181: (2019)
Universidad de Sevilla
Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.EBI
Bioorg Med Chem Lett 29: 2655-2658 (2019)
University of Tsukuba
Incorporation of privileged structures into 3-O-?-chacotriosyl ursolic acid can enhance inhibiting the entry of the H5N1 virus.EBI
Bioorg Med Chem Lett 29: 2675-2680 (2019)
South China Agricultural University
Design, synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives as novel xanthine oxidase inhibitors.EBI
Eur J Med Chem 181: (2019)
Shenyang Pharmaceutical University
Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1-XPF.EBI
J Med Chem 62: 7684-7696 (2019)
University of Alberta
Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases.EBI
J Med Chem 62: 7643-7655 (2019)
Merck KGaA
Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor EBI
J Med Chem 62: 7976-7997 (2019)
Boehringer Ingelheim RCV GmbH & Co. KG
Ophiobolin-Type Sesterterpenoids from the Mangrove Endophytic Fungus EBI
J Nat Prod 82: 2268-2278 (2019)
Sun Yat-sen University
Synthesis and biological evaluation of 7-methoxy-1-(3,4,5-trimethoxyphenyl)-4,5-dihydro-2H-benzo[e]indazoles as new colchicine site inhibitors.EBI
Bioorg Med Chem Lett 29: 2632-2634 (2019)
Second Military Medical University
A fragment-like approach to PYCR1 inhibition.EBI
Bioorg Med Chem Lett 29: 2626-2631 (2019)
University of Strathclyde
Synthesis and evaluation of 2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione derivatives as Mnk inhibitors.EBI
Bioorg Med Chem Lett 29: 2650-2654 (2019)
University of South Australia
Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis.EBI
Bioorg Med Chem Lett 29: 2700-2705 (2019)
Bayer AG
Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl-1 Inhibitor (AZD5991) and Other Synthetic Macrocycles.EBI
J Med Chem 62: 9418-9437 (2019)
AstraZeneca
Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity?EBI
J Med Chem 62: 10497-10525 (2019)
University of S£o Paulo
Further exploration of an N-aryl phenoxyethoxy pyridinone-based series of mGluEBI
Bioorg Med Chem Lett 29: 2670-2674 (2019)
Vanderbilt University
Design, synthesis and evaluation of biphenyl imidazole analogues as potent antifungal agents.EBI
Bioorg Med Chem Lett 29: 2448-2451 (2019)
Shenyang Pharmaceutical University
Towards multi-target antidiabetic agents: Discovery of biphenyl-benzimidazole conjugates as AMPK activators.EBI
Bioorg Med Chem Lett 29: 2443-2447 (2019)
Volgograd State Medical University
Identification of new aryl hydrocarbon receptor (AhR) antagonists using a zebrafish model.EBI
Bioorg Med Chem 27: (2019)
Gwangju Institute of Science and Technology
Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs.EBI
Eur J Med Chem 180: 673-689 (2019)
Medical University of Lublin
Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships.EBI
Eur J Med Chem 180: 656-672 (2019)
Wuhan Institute of Technology
Synthesis and biological evaluation of moxifloxacin-acetyl-1,2,3-1H-triazole-methylene-isatin hybrids as potential anti-tubercular agents against both drug-susceptible and drug-resistant Mycobacterium tuberculosis strains.EBI
Eur J Med Chem 180: 648-655 (2019)
Medical School of Nanjing University
Peptide derivatives as inhibitors of NS2B-NS3 protease from Dengue, West Nile, and Zika flaviviruses.EBI
Bioorg Med Chem 27: 3963-3978 (2019)
Federal University of Alagoas
Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPAR?-selective agonist.EBI
Bioorg Med Chem 27: 4059-4068 (2019)
University of Oslo
Symmetry-based ligand design and evaluation of small molecule inhibitors of programmed cell death-1/programmed death-ligand 1 interaction.EBI
Bioorg Med Chem Lett 29: 2464-2467 (2019)
Japan Tobacco Inc.
Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors.EBI
Eur J Med Chem 180: 637-647 (2019)
University of Campania "L. Vanvitelli"
Expedient assembly of Oligo-LacNAcs by a sugar nucleotide regeneration system: Finding the role of tandem LacNAc and sialic acid position towards siglec binding.EBI
Eur J Med Chem 180: 627-636 (2019)
National Tsing-Hua University
A novel class of multitarget anti-Alzheimer benzohomoadamantane?chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.EBI
Eur J Med Chem 180: 613-626 (2019)
University of Barcelona
Structure-aided optimization of 3-O-?-chacotriosyl ursolic acid as novel H5N1 entry inhibitors with high selective index.EBI
Bioorg Med Chem 27: 4048-4058 (2019)
South China Agricultural University
Comparative analysis of stilbene and benzofuran neolignan derivatives as acetylcholinesterase inhibitors with neuroprotective and anti-inflammatory activities.EBI
Bioorg Med Chem Lett 29: 2475-2479 (2019)
Gifu University
Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2.EBI
Bioorg Med Chem Lett 29: 2516-2524 (2019)
Mercachem BV
Sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as potent carbonic anhydrase II/IX/XII inhibitors.EBI
Bioorg Med Chem 27: 3889-3901 (2019)
University of Sharjah
COX-1/COX-2 inhibition activities and molecular docking study of newly designed and synthesized pyrrolo[3,4-c]pyrrole Mannich bases.EBI
Bioorg Med Chem 27: 3918-3928 (2019)
Wroclaw Medical University
Rational modification of Mannich base-type derivatives as novel antichagasic compounds: Synthesis, in vitro and in vivo evaluation.EBI
Bioorg Med Chem 27: 3902-3917 (2019)
Universidad de Navarra
Discovery of human lactate dehydrogenase 5 inhibitors (hLDH5) with anti-lung cancer activity through an in silico method and biological validation.EBI
Bioorg Med Chem Lett 29: 2459-2463 (2019)
The 5th Affiliated Hospital of Shenzhen University Health Science Center
An insight into the medicinal perspective of synthetic analogs of indole: A review.EBI
Eur J Med Chem 180: 562-612 (2019)
ISF College of Pharmacy
Cell-active carbazole derivatives as inhibitors of the zika virus protease.EBI
Eur J Med Chem 180: 536-545 (2019)
University of Patras
Synthesis and Structure-Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents.EBI
J Med Chem 62: 6958-6971 (2019)
Toho University
Design, Synthesis, and Biological Characterization of Orally Active 17?-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis.EBI
J Med Chem 62: 7289-7301 (2019)
ElexoPharm GmbH
Identification of ?-Mangostin as a Potential Inhibitor of Microtubule Affinity Regulating Kinase 4.EBI
J Nat Prod 82: 2252-2261 (2019)
Jamia Millia Islamia University
Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity.EBI
J Med Chem 62: 6913-6924 (2019)
Servier Research Institute of Medicinal Chemistry
Rapid generation of novel benzoic acid-based xanthine derivatives as highly potent, selective and long acting DPP-4 inhibitors: Scaffold-hopping and prodrug study.EBI
Eur J Med Chem 180: 509-523 (2019)
Guangxi Medical University
Discovery and Development of a Series of Pyrazolo[3,4-EBI
J Med Chem 62: 7473-7488 (2019)
Shanghai University
Discovery of 4-Methylquinazoline Based PI3K Inhibitors for the Potential Treatment of Idiopathic Pulmonary Fibrosis.EBI
J Med Chem 62: 8873-8879 (2019)
TBA
5-Lipoxygenase as a drug target: A review on trends in inhibitors structural design, SAR and mechanism based approach.EBI
Bioorg Med Chem 27: 3745-3759 (2019)
School of Advanced Sciences
Role of sulphur-heterocycles in medicinal chemistry: An update.EBI
Eur J Med Chem 180: 486-508 (2019)
Maharaja Ranjit Singh Punjab Technical University
Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors.EBI
Eur J Med Chem 180: 449-456 (2019)
Purdue University
Design, synthesis, biological evaluation of benzoyl amide derivatives containing nitrogen heterocyclic ring as potential VEGFR-2 inhibitors.EBI
Bioorg Med Chem 27: 3813-3824 (2019)
Zhengzhou Children's Hospital
Discovery of a novel orally active TRPV4 inhibitor: Part 1. Optimization from an HTS hit.EBI
Bioorg Med Chem 27: 3775-3787 (2019)
Astellas Pharma Inc.
Identification and characterization of the first fragment hits for SETDB1 Tudor domain.EBI
Bioorg Med Chem 27: 3866-3878 (2019)
University of Toronto
Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors.EBI
Bioorg Med Chem 27: 3998-4012 (2019)
Vrije Universiteit Amsterdam
Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells.EBI
Bioorg Med Chem Lett 29: 2503-2510 (2019)
Meyer Cancer Center
An overview on chemical structures as ?F508-CFTR correctors.EBI
Eur J Med Chem 180: 430-448 (2019)
University of Palermo
Urea moiety as amide bond mimetic in peptide-like inhibitors of VEGF-AEBI
Bioorg Med Chem Lett 29: 2493-2497 (2019)
University of Warsaw
Design, synthesis and biological evaluation of 6-deoxy O-spiroketal C-arylglucosides as novel renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.EBI
Eur J Med Chem 180: 398-416 (2019)
Chinese Academy of Sciences
Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HTEBI
Eur J Med Chem 180: 383-397 (2019)
Medical University of Warsaw
Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease.EBI
Eur J Med Chem 180: 367-382 (2019)
Zhejiang University
Design, synthesis and biological evaluation of chalcones as reversers of P-glycoprotein-mediated multidrug resistance.EBI
Eur J Med Chem 180: 350-366 (2019)
East China University of Science and Technology
Total synthesis of dryocrassin ABBA and its analogues with potential inhibitory activity against drug-resistant neuraminidases.EBI
Bioorg Med Chem 27: 3846-3852 (2019)
Chinese Academy of Sciences
Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase.EBI
Bioorg Med Chem 27: 3836-3845 (2019)
Shandong University
Design and synthesis of biotinylated Hexylselen as a probe to identify KGA allosteric inhibitors by a convenient biomolecular interaction assay.EBI
Bioorg Med Chem Lett 29: 2498-2502 (2019)
Zhejiang University
The parmodulin NRD-21 is an allosteric inhibitor of PAR1 Gq signaling with improved anti-inflammatory activity and stability.EBI
Bioorg Med Chem 27: 3788-3796 (2019)
Marquette University
Structural development of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives as human peroxisome proliferator-activated receptor alpha (PPAR?)-selective agonists.EBI
Bioorg Med Chem Lett 29: 2124-2128 (2019)
Okayama University
Strategies to develop selective CBEBI
Eur J Med Chem 180: 291-309 (2019)
The University of Sydney
Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents.EBI
Eur J Med Chem 180: 268-282 (2019)
University of Trieste
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.EBI
J Med Chem 62: 8973-8995 (2019)
TBA
Naturally Occurring Lumazines.EBI
J Nat Prod 82: 2054-2065 (2019)
University of Auckland
Identification of EBI
J Med Chem 62: 8953-8972 (2019)
TBA
Synthesis and Biological Activity of Peptide ?-Ketoamide Derivatives as Proteasome Inhibitors.EBI
ACS Med Chem Lett 10: 1086-1092 (2019)
University of Ferrara
Targeting IRAK4 for Degradation with PROTACs.EBI
ACS Med Chem Lett 10: 1081-1085 (2019)
GlaxoSmithKline Medicines Research Centre
Rigidification Dramatically Improves Inhibitor Selectivity for RAF Kinases.EBI
ACS Med Chem Lett 10: 1074-1080 (2019)
University of Southern California
Discovery of a Novel Selective Dual Peroxisome Proliferator-Activated Receptor ?/? Agonist for the Treatment of Primary Biliary Cirrhosis.EBI
ACS Med Chem Lett 10: 1068-1073 (2019)
WuXi AppTec (Shanghai) Co., Ltd
Antioxidant, Anti-inflammatory, and Neuroprotective Effects of Novel Vinyl Sulfonate Compounds as Nrf2 Activator.EBI
ACS Med Chem Lett 10: 1061-1067 (2019)
Korea Institute of Science and Technology (KIST)
Development of Highly Selective Pyrimidine-Based Aldosterone Synthase (CYP11B2) Inhibitors.EBI
ACS Med Chem Lett 10: 1056-1060 (2019)
Selenity Therapeutics
DL5050, a Selective Agonist for the Human Constitutive Androstane Receptor.EBI
ACS Med Chem Lett 10: 1039-1044 (2019)
University of Maryland
Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors.EBI
ACS Med Chem Lett 10: 1033-1038 (2019)
Prelude Therapeutics
Treatment of Cancers by Inhibition of Isoprenylcysteine Carboxyl Methyltransferase.EBI
ACS Med Chem Lett 10: 1024-1025 (2019)
Usona Institute
Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927.EBI
Bioorg Med Chem Lett 29: 2090-2093 (2019)
Genentech Inc.
Phenylhydrazides as inhibitors of Leishmania amazonensis arginase and antileishmanial activity.EBI
Bioorg Med Chem 27: 3853-3859 (2019)
Universidade Federal do Rio de Janeiro
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.EBI
Eur J Med Chem 180: 238-252 (2019)
Nanyang Normal University
2-Amino-2,3-dihydro-1EBI
J Med Chem 62: 7431-7444 (2019)
Jinan University
Tapping the therapeutic potential of protein tyrosine phosphatase 4A with small molecule inhibitors.EBI
Bioorg Med Chem Lett 29: 2008-2015 (2019)
University of Pittsburgh
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.EBI
Bioorg Med Chem Lett 29: 2294-2301 (2019)
Genentech
Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus.EBI
Bioorg Med Chem 27: (2019)
Imperial College London
2-(phenylthio)ethylidene derivatives as anti-Trypanosoma cruzi compounds: Structural design, synthesis and antiparasitic activity.EBI
Eur J Med Chem 180: 191-203 (2019)
Universidade de Pernambuco
Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors.EBI
Eur J Med Chem 180: 171-190 (2019)
Fudan University
Evolution in medicinal chemistry of sorafenib derivatives for hepatocellular carcinoma.EBI
Eur J Med Chem 179: 916-935 (2019)
Fuzhou University
Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase.EBI
J Med Chem 62: 7489-7505 (2019)
Achaogen Inc.
Cyclization of RGD Peptides by Suzuki-Miyaura Cross-Coupling.EBI
J Med Chem 62: 7417-7430 (2019)
Bielefeld University
Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity.EBI
J Med Chem 62: 6894-6912 (2019)
Universit£ degli Studi di Firenze
Synthesis and biological evaluation of novel benzo[c][1,2,5]thiadiazol-5-yl and thieno[3,2-c]- pyridin-2-yl imidazole derivatives as ALK5 inhibitors.EBI
Bioorg Med Chem Lett 29: 2070-2075 (2019)
Yanbian University
Structure-activity relationships of thiazole and benzothiazole derivatives as selective cannabinoid CB2 agonists with in vivo anti-inflammatory properties.EBI
Eur J Med Chem 180: 154-170 (2019)
German University in Cairo
Functionalized 6-(piperidin-1-yl)-8,9-diphenyl purines as inverse agonists of the CB1 receptor - SAR efforts towards selectivity and peripheralization.EBI
Bioorg Med Chem 27: 3632-3649 (2019)
RTI International
Synthesis, SAR study, and biological evaluation of novel 2,3-dihydro-1H-imidazo[1,2-a]benzimidazole derivatives as phosphodiesterase 10A inhibitors.EBI
Bioorg Med Chem 27: 3692-3706 (2019)
Astellas Pharma Inc.
Synthesis, pharmacological evaluation, and mechanistic study of adefovir mixed phosphonate derivatives bearing cholic acid and l-amino acid moieties for the treatment of HBV.EBI
Bioorg Med Chem 27: 3707-3721 (2019)
Guizhou Medical University
Synthesis of peptidomimetics and chemo-biological tools for CD95/PLC?1 interaction analysis.EBI
Bioorg Med Chem Lett 29: 2094-2099 (2019)
CLCC Eug�ne Marquis, INSERM, Univ Rennes 1, UMR1242, rue Bataille Flandres Dunkerque, 35042 Rennes, France; Equipe Ligue Contre Le Cancer, rue Bataille Flandres Dunkerque, 35042 Rennes, France.
Discovery, synthesis, and in vitro evaluation of a novel bioactive peptide for ACE and DPP-IV inhibitory activity.EBI
Eur J Med Chem 180: 99-110 (2019)
University of Mysore
Design of balanced COX inhibitors based on anti-inflammatory and/or COX-2 inhibitory ascidian metabolites.EBI
Eur J Med Chem 180: 86-98 (2019)
Pusan National University
Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors.EBI
Eur J Med Chem 180: 72-85 (2019)
Hangzhou Institute of Innovative Medicine
Merging memantine and ferulic acid to probe connections between NMDA receptors, oxidative stress and amyloid-? peptide in Alzheimer's disease.EBI
Eur J Med Chem 180: 111-120 (2019)
Alma Mater Studiorum - University of Bologna
A new approach to procyanidins synthesis with potent anti-adipogenic effects.EBI
Bioorg Med Chem Lett 29: 2079-2084 (2019)
Daegu University
1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview.EBI
Bioorg Med Chem 27: 3511-3531 (2019)
Chinese Academy of Sciences
Development of novel lithocholic acid derivatives as vitamin D receptor agonists.EBI
Bioorg Med Chem 27: 3674-3681 (2019)
Tokyo Medical and Dental University
Novel N-aryl nicotinamide derivatives: Taking stock on 3,6-diazabicyclo[3.1.1]heptanes as ligands for neuronal acetylcholine receptors.EBI
Eur J Med Chem 180: 51-61 (2019)
Universit£ di Sassari
Design, synthesis, biological evaluation and docking study of novel indole-2-amide as anti-inflammatory agents with dual inhibition of COX and 5-LOX.EBI
Eur J Med Chem 180: 41-50 (2019)
Anhui University of Chinese Medicine
Design, synthesis, and antifibrosis evaluation of 4-(benzo-[c][1,2,5]thiadiazol-5-yl)-3(5)-(6-methyl- pyridin-2-yl)pyrazole and 3(5)-(6-methylpyridin- 2-yl)-4-(thieno-[3,2,-c]pyridin-2-yl)pyrazole derivatives.EBI
Eur J Med Chem 180: 15-27 (2019)
Yanbian University
Probing the Existence of a Metastable Binding Site at the ?EBI
J Med Chem 62: 7806-7839 (2019)
University of Copenhagen
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design.EBI
J Med Chem 62: 7264-7288 (2019)
Chinese Academy of Sciences
Design, Synthesis, Evaluation, and Structural Studies of EBI
J Med Chem 62: 7250-7263 (2019)
Jagiellonian University
Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFREBI
J Med Chem 62: 7302-7308 (2019)
Jinan University
Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68).EBI
J Med Chem 62: 7557-7574 (2019)
Icahn School of Medicine at Mount Sinai
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.EBI
J Med Chem 62: 7058-7069 (2019)
Chinese Academy of Sciences
Synthesis and biological evaluation of 1-alkylaminomethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii.EBI
Bioorg Med Chem 27: 3663-3673 (2019)
Universidad de Buenos Aires
Oxadiazole scaffolds in anti-tuberculosis drug discovery.EBI
Bioorg Med Chem Lett 29: 1999-2007 (2019)
Institute of Chemical Technology
Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines.EBI
J Med Chem 62: 7089-7110 (2019)
University of Naples Federico II
Mechanistic Insight on the Mode of Action of Colletoic Acid.EBI
J Med Chem 62: 6925-6940 (2019)
The University of Tennessee Health Science Center
Development of Dual Chitinase Inhibitors as Potential New Treatment for Respiratory System Diseases.EBI
J Med Chem 62: 7126-7145 (2019)
OncoArendi Therapeutics SA
Design, synthesis, and evaluation of novel N-(4-phenoxybenzyl)aniline derivatives targeting acetylcholinesterase, ?-amyloid aggregation and oxidative stress to treat Alzheimer's disease.EBI
Bioorg Med Chem 27: 3650-3662 (2019)
Indian Institute of Technology (Banaras Hindu University)
Optimization of oxadiazole derivatives with a spirocyclic cyclohexane structure as novel GPR119 agonists.EBI
Bioorg Med Chem Lett 29: 2100-2106 (2019)
Japan Tobacco Inc.
A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SFEBI
Eur J Med Chem 180: 1-14 (2019)
Cardiff University
Boron in drug design: Recent advances in the development of new therapeutic agents.EBI
Eur J Med Chem 179: 791-804 (2019)
S£o Paulo State University
Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles.EBI
Eur J Med Chem 179: 779-790 (2019)
Tel Aviv University
Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis.EBI
J Med Chem 62: 7233-7249 (2019)
Universit£ degli Studi di Firenze
Biological evaluation of molecules of the azaBINOL class as antiviral agents: Inhibition of HIV-1 RNase H activity by 7-isopropoxy-8-(naphth-1-yl)quinoline.EBI
Bioorg Med Chem 27: 3595-3604 (2019)
Oregon State University
Discovery and characterization of trypanocidal cysteine protease inhibitors from the 'malaria box'.EBI
Eur J Med Chem 179: 765-778 (2019)
Universidade Federal de Minas Gerais
Identification and characterization of a novel chemotype for human TLR8 inhibitors.EBI
Eur J Med Chem 179: 744-752 (2019)
Freie Universit£t Berlin
Novel potent substituted 4-amino-2-thiopyrimidines as dual VEGFR-2 and BRAF kinase inhibitors.EBI
Eur J Med Chem 179: 707-722 (2019)
National Research Centre
Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity.EBI
J Med Chem 62: 6796-6813 (2019)
China Pharmaceutical University
Discovery of 3-Oxabicyclo[4.1.0]heptane, a Non-nitrogen Containing Morpholine Isostere, and Its Application in Novel Inhibitors of the PI3K-AKT-mTOR Pathway.EBI
J Med Chem 62: 6972-6984 (2019)
GlaxoSmithKline R&D
Novel and Selective TLR7 Antagonists among the Imidazo[1,2-EBI
J Med Chem 62: 7015-7031 (2019)
Universit£ de Montpellier
Linear and Rationally Designed Stapled Peptides Abrogate TLR4 Pathway and Relieve Inflammatory Symptoms in Rheumatoid Arthritis Rat Model.EBI
J Med Chem 62: 6495-6511 (2019)
Ajou University
3-[(1EBI
J Med Chem 62: 6876-6893 (2019)
Peloton Therapeutics, Inc.
Molecular and cellular studies evaluating a potent 2-cyanoindolizine catechol diether NNRTI targeting wildtype and Y181C mutant HIV-1 reverse transcriptase.EBI
Bioorg Med Chem Lett 29: 2182-2188 (2019)
Yale University
Synthesis and evaluation of tetrahydropyrazolopyridine inhibitors of anion exchange protein SLC26A4 (pendrin).EBI
Bioorg Med Chem Lett 29: 2119-2123 (2019)
University of California
Dual functional cholinesterase and PDE4D inhibitors for the treatment of Alzheimer's disease: Design, synthesis and evaluation of tacrine-pyrazolo[3,4-b]pyridine hybrids.EBI
Bioorg Med Chem Lett 29: 2150-2152 (2019)
Sun Yat-sen University
2-Aryladenine derivatives as a potent scaffold for AEBI
Bioorg Med Chem 27: 3551-3558 (2019)
Universidade do Minho
Novel N-benzylpiperidine carboxamide derivatives as potential cholinesterase inhibitors for the treatment of Alzheimer's disease.EBI
Eur J Med Chem 179: 680-693 (2019)
University of Pretoria
Design, synthesis, and in vitro bioactivity evaluation of fluorine-containing analogues for sphingosine-1-phosphate 2 receptor.EBI
Bioorg Med Chem 27: 3619-3631 (2019)
Washington University
Design, synthesis and biological evaluation of novel FFA1/GPR40 agonists: New breakthrough in an old scaffold.EBI
Eur J Med Chem 179: 608-622 (2019)
China Pharmaceutical University
Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents.EBI
Eur J Med Chem 179: 576-590 (2019)
Medical University of Gdansk
Styryl quinazolinones and its ethynyl derivatives induce myeloid differentiation.EBI
Bioorg Med Chem Lett 29: 2286-2289 (2019)
National University of Singapore
Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening.EBI
Eur J Med Chem 179: 557-566 (2019)
Univ. Lille
Application of hydrazino and hydrazido linkers to connect benzenesulfonamides with hydrophilic/phobic tails for targeting the middle region of human carbonic anhydrases active site: Selective inhibitors of hCA IX.EBI
Eur J Med Chem 179: 547-556 (2019)
Cairo University
Recent progress in histone methyltransferase (G9a) inhibitors as anticancer agents.EBI
Eur J Med Chem 179: 537-546 (2019)
Southern Medical University
Endomorphin-2 analogs containing modified tyrosines: Biological and theoretical investigation of the influence on conformation and pharmacological profile.EBI
Eur J Med Chem 179: 527-536 (2019)
Medical University of Lodz
Novel phenanthridin-6(5H)-one derivatives as potent and selective BET bromodomain inhibitors: Rational design, synthesis and biological evaluation.EBI
Eur J Med Chem 179: 502-514 (2019)
Henan University of Traditional Chinese Medicine
Alkaloids Purified from EBI
J Nat Prod 82: 1953-1960 (2019)
American University of Health Sciences
Monosaccharide Analogues of Anticancer Peptide R-Lycosin-I: Role of Monosaccharide Conjugation in Complexation and the Potential of Lung Cancer Targeting and Therapy.EBI
J Med Chem 62: 7857-7873 (2019)
TBA
Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens.EBI
J Med Chem 62: 7445-7472 (2019)
Angelini S.p.A.
Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases.EBI
J Med Chem 62: 6512-6524 (2019)
University of California
Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633).EBI
J Med Chem 62: 6751-6764 (2019)
ORIC Pharmaceuticals
Route to Prolonged Residence Time at the Histamine HEBI
J Med Chem 62: 6630-6644 (2019)
VU University Amsterdam
Green synthesis, biological evaluation, molecular docking studies and 3D-QSAR analysis of novel phenylalanine linked quinazoline-4(3H)-one-sulphonamide hybrid entities distorting the malarial reductase activity in folate pathway.EBI
Bioorg Med Chem 27: 3574-3586 (2019)
Affiliated to Sardar Patel University
Melanogenic inhibitory effects of Triangularin in B16F0 melanoma cells, in vitro and molecular docking studies.EBI
Bioorg Med Chem 27: 3722-3728 (2019)
Universidad Nacional de C£rdoba
Discovery and pharmacological evaluation of indole derivatives as potent and selective ROR?t inverse agonist for multiple autoimmune conditions.EBI
Bioorg Med Chem Lett 29: 2208-2217 (2019)
Advinus Therapeutics Limited
Discovery of novel 9H-purin derivatives as dual inhibitors of HDAC1 and CDK2.EBI
Bioorg Med Chem Lett 29: 2136-2140 (2019)
Chongqing Medical University
Sulfonamide derivatives as multi-target agents for complex diseases.EBI
Bioorg Med Chem Lett 29: 2042-2050 (2019)
University of Massachusetts Boston
Synthesis of novel galeterone derivatives and evaluation of their in vitro activity against prostate cancer cell lines.EBI
Eur J Med Chem 179: 483-492 (2019)
The Czech Academy of Sciences
Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors.EBI
Eur J Med Chem 179: 470-482 (2019)
Chinese Academy of Sciences
Bis(het)aryl-1,2,3-triazole quinuclidines as ?7 nicotinic acetylcholine receptor ligands: Synthesis, structure affinity relationships, agonism activity, [EBI
Eur J Med Chem 179: 449-469 (2019)
Universit£ d'Orl£ans
Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity.EBI
J Med Chem 62: 7042-7057 (2019)
Institute of Biotechnology of the Czech Academy of Sciences
Homoharringtonine stabilizes secondary structure of guanine-rich sequence existing in the 5'-untranslated region of Nrf2.EBI
Bioorg Med Chem Lett 29: 2189-2196 (2019)
Dongguk University
Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-?-lactamases.EBI
J Med Chem 62: 7160-7184 (2019)
Sichuan University
Prenylated Stilbenoids Affect Inflammation by Inhibiting the NF-?B/AP-1 Signaling Pathway and Cyclooxygenases and Lipoxygenase.EBI
J Nat Prod 82: 1839-1848 (2019)
Czech Academy of Sciences
Probing the Ligand-Binding Pocket of BTN3A1.EBI
J Med Chem 62: 6814-6823 (2019)
Western Michigan University
Norepinephrine-Transporter-Targeted and DNA-Co-Targeted Theranostic Guanidines.EBI
J Med Chem 63: 2051-2073 (2020)
University of Nebraska Medical Center
7-Methylation of Chenodeoxycholic Acid Derivatives Yields a Substantial Increase in TGR5 Receptor Potency.EBI
J Med Chem 62: 6824-6830 (2019)
University of Minnesota
A- and D-Ring Structural Modifications of an Androsterone Derivative Inhibiting 17?-Hydroxysteroid Dehydrogenase Type 3: Chemical Synthesis and Structure-Activity Relationships.EBI
J Med Chem 62: 7070-7088 (2019)
CHU de Queb£c-Research Center
Multistage Screening Reveals 3-Substituted Indolin-2-one Derivatives as Novel and Isoform-Selective c-Jun N-terminal Kinase 3 (JNK3) Inhibitors: Implications to Drug Discovery for Potential Treatment of Neurodegenerative Diseases.EBI
J Med Chem 62: 6645-6664 (2019)
Peking University
Polycerasoidol, a Natural Prenylated Benzopyran with a Dual PPAR?/PPAR? Agonist Activity and Anti-inflammatory Effect.EBI
J Nat Prod 82: 1802-1812 (2019)
University of Valencia
Small-molecule agents for the treatment of inflammatory bowel disease.EBI
Bioorg Med Chem Lett 29: 2034-2041 (2019)
Gilead Sciences
Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors.EBI
Eur J Med Chem 179: 404-422 (2019)
NTZ Lab Ltd.
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[EBI
J Med Chem 62: 6482-6494 (2019)
GlaxoSmithKline
Bisubstrate Inhibitors of Nicotinamide EBI
J Med Chem 62: 6597-6614 (2019)
Leiden University
Discovery of Clinical Candidate (1EBI
J Med Chem 62: 6705-6733 (2019)
NewLink Genetics Corporation
Design, synthesis and biological evaluations of 2-amino-4-(1-piperidine) pyridine derivatives as novel anti crizotinib-resistant ALK/ROS1 dual inhibitors.EBI
Eur J Med Chem 179: 358-375 (2019)
Southern Medical University
Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells.EBI
Eur J Med Chem 179: 347-357 (2019)
Universit£ de Moncton
TASK Channels Pharmacology: New Challenges in Drug Design.EBI
J Med Chem 62: 10044-10058 (2019)
Universidad de Talca
Chivosazole A Modulates Protein-Protein Interactions of Actin.EBI
J Nat Prod 82: 1961-1970 (2019)
Ludwig-Maximilians-University
Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).EBI
J Med Chem 62: 8996-9007 (2019)
Icahn School of Medicine at Mount Sinai
Discovery of 4-Aminoquinoline-3-carboxamide Derivatives as Potent Reversible Bruton's Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis.EBI
J Med Chem 62: 6561-6574 (2019)
Tsinghua University
Discovery of a Potent and Selective CCR4 Antagonist That Inhibits TEBI
J Med Chem 62: 6190-6213 (2019)
RAPT Therapeutics
The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as DEBI
J Med Chem 62: 6287-6314 (2019)
National Institute on Drug Abuse-Intramural Research Program
Benzylideneacetone Derivatives Inhibit Osteoclastogenesis and Activate Osteoblastogenesis Independently Based on Specific Structure-Activity Relationship.EBI
J Med Chem 62: 6063-6082 (2019)
Korea University
Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as ROR?t inverse agonists.EBI
Bioorg Med Chem Lett 29: 2265-2269 (2019)
Bristol-Myers Squibb Company
Strategies for the development of highly selective cytochrome P450 inhibitors: Several CYP targets in current research.EBI
Bioorg Med Chem Lett 29: 2016-2024 (2019)
Shenyang Pharmaceutical University
Design, synthesis and biological evaluation of hypolipidemic compounds based on BRD4 inhibitor RVX-208.EBI
Bioorg Med Chem Lett 29: 2168-2172 (2019)
Southeast University
New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.EBI
Bioorg Med Chem 27: 3546-3550 (2019)
University of Leeds
Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A.EBI
J Med Chem 62: 7146-7159 (2019)
Cancer Therapeutics CRC
Design, synthesis and biological evaluation of 2-hydrazinyladenosine derivatives as AEBI
Eur J Med Chem 179: 310-324 (2019)
National Engineering Research Center for the Emergency Drug
Human disorders associated with inflammation and the evolving role of natural products to overcome.EBI
Eur J Med Chem 179: 272-309 (2019)
University of Delhi
Sulfamates in drug design and discovery: Pre-clinical and clinical investigations.EBI
Eur J Med Chem 179: 257-271 (2019)
University of Sharjah
Structure-activity relationship study and biological evaluation of SAC-Garlic acid conjugates as novel anti-inflammatory agents.EBI
Eur J Med Chem 179: 233-245 (2019)
Southern Medical University
Rational approaches, design strategies, structure activity relationship and mechanistic insights for therapeutic coumarin hybrids.EBI
Bioorg Med Chem 27: 3477-3510 (2019)
Guru Nanak Dev University
Modification of the 4-phenylbutyl side chain of potent 3-benzazepine-based GluN2B receptor antagonists.EBI
Bioorg Med Chem 27: 3559-3567 (2019)
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster
Design, synthesis and activity of novel 2,6-disubstituted purine derivatives, potential small molecule inhibitors of signal transducer and activator of transcription 3.EBI
Eur J Med Chem 179: 218-232 (2019)
Wenzhou Medical University
Discovery of novel pyrimidine-based benzothiazole derivatives as potent cyclin-dependent kinase 2 inhibitors with anticancer activity.EBI
Eur J Med Chem 179: 196-207 (2019)
Southern Medical University
Design, synthesis and molecular modelling of new bulky Fananserin derivatives with altered pharmacological profile as potential antidepressants.EBI
Bioorg Med Chem 27: 3396-3407 (2019)
Cracow University of Technology
Discovery of BR102375, a new class of non-TZD PPAR? full agonist for the treatment of type 2 diabetes.EBI
Bioorg Med Chem Lett 29: 2275-2282 (2019)
Boryung Pharmaceuticals Co. Ltd.
New dual ligands for the DEBI
Bioorg Med Chem Lett 29: 2236-2242 (2019)
Cracow University of Technology
Inhibition of neutral lipid synthesis by avarols from a marine sponge.EBI
Bioorg Med Chem Lett 29: 2283-2285 (2019)
Kitasato University
Design, synthesis and in vitro evaluation of 6-amide-2-aryl benzoxazole/benzimidazole derivatives against tumor cells by inhibiting VEGFR-2 kinase.EBI
Eur J Med Chem 179: 147-165 (2019)
Yunnan University
Light-controlled inhibition of BRAFV600E kinase.EBI
Eur J Med Chem 179: 133-146 (2019)
University Medical Center Groningen
Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions.EBI
J Med Chem 62: 7185-7209 (2019)
Monash University
De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives.EBI
J Med Chem 62: 6615-6629 (2019)
Max Planck Institute for Developmental Biology
Discovery of 2-(4-Chloro-3-(trifluoromethyl)phenyl)-EBI
J Med Chem 62: 6083-6101 (2019)
Chinese Academy of Sciences
SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic MEBI
Bioorg Med Chem Lett 29: 2224-2228 (2019)
Vanderbilt University
Synthesis and biological evaluation of PSMA-targeting paclitaxel conjugates.EBI
Bioorg Med Chem Lett 29: 2229-2235 (2019)
Lomonosov Moscow State University
l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan.EBI
Bioorg Med Chem Lett 29: 2254-2258 (2019)
University of Nebraska at Kearney
Human constitutive androstane receptor agonist DL5016: A novel sensitizer for cyclophosphamide-based chemotherapies.EBI
Eur J Med Chem 179: 84-99 (2019)
University of Maryland
Selective Toll-like receptor 7 agonists with novel chromeno[3,4-d]imidazol-4(1H)-one and 2-(trifluoromethyl)quinoline/ quinazoline-4-amine scaffolds.EBI
Eur J Med Chem 179: 109-122 (2019)
University of Ljubljana
Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy.EBI
J Med Chem 62: 7400-7416 (2019)
Bristol-Myers Squibb Research & Development
Molecular Networking Reveals the Chemical Diversity of Selaginellin Derivatives, Natural Phosphodiesterase-4 Inhibitors from EBI
J Nat Prod 82: 1820-1830 (2019)
Seoul National University
Meroterpenoids with BACE1 Inhibitory Activity from the Fruiting Body of EBI
J Nat Prod 82: 1797-1801 (2019)
Meiji Pharmaceutical University
Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-? Motif Kinase (ZAK) Inhibitors.EBI
J Med Chem 63: 2114-2130 (2020)
Jinan University
Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues.EBI
J Med Chem 62: 6346-6362 (2019)
Seoul National University
(EBI
J Med Chem 62: 6241-6261 (2019)
University of Basel
Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction.EBI
J Med Chem 62: 6015-6034 (2019)
TBA
Philanthotoxin Analogues That Selectively Inhibit Ganglionic Nicotinic Acetylcholine Receptors with Exceptional Potency.EBI
J Med Chem 62: 6214-6222 (2019)
University of Nottingham
Engineered Substrate for Cyclooxygenase-2: A Pentapeptide Isoconformational to Arachidonic Acid for Managing Inflammation.EBI
J Med Chem 62: 6363-6376 (2019)
TBA
Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light.EBI
J Med Chem 62: 7583-7588 (2019)
China Pharmaceutical University
Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors.EBI
J Med Chem 62: 6391-6397 (2019)
Gr�nenthal GmbH
Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity.EBI
Eur J Med Chem 178: 782-801 (2019)
China Pharmaceutical University
Structure-activity relationship study of thiazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors.EBI
Bioorg Med Chem 27: 3408-3420 (2019)
Sungkyunkwan University
Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety.EBI
Bioorg Med Chem 27: 3440-3450 (2019)
Mitsubishi Tanabe Pharma Corporation
Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence.EBI
Bioorg Med Chem Lett 29: 2316-2319 (2019)
Novartis Institutes for BioMedical Research
The discovery of novel 3-aryl-indazole derivatives as peripherally restricted pan-Trk inhibitors for the treatment of pain.EBI
Bioorg Med Chem Lett 29: 2320-2326 (2019)
Asahi Kasei Pharma Corporation
Discovery of novel biaryl sulfonamide based Mcl-1 inhibitors.EBI
Bioorg Med Chem Lett 29: 2375-2382 (2019)
FORMA Therapeutics
Discovery and structure-activity relationship of novel diphenylthiazole derivatives as BTK inhibitor with potent activity against B cell lymphoma cell lines.EBI
Eur J Med Chem 178: 767-781 (2019)
Nankai University
Design, synthesis and antitumor study of a series of N-Cyclic sulfamoylaminoethyl substituted 1,2,5-oxadiazol-3-amines as new indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors.EBI
Eur J Med Chem 179: 38-55 (2019)
Shanghai Institute of Materia Medica (SIMM)
Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens VoseviEBI
Bioorg Med Chem Lett 29: 2415-2427 (2019)
Gilead Sciences
2-Aminoimidazole-based antagonists of the 5-HTEBI
Eur J Med Chem 179: 1-15 (2019)
Polish Academy of Sciences
Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HTEBI
Eur J Med Chem 178: 740-751 (2019)
Jagiellonian University
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.EBI
Eur J Med Chem 178: 726-739 (2019)
Nanyang Normal University
2,7-naphthyridinone-based MET kinase inhibitors: A promising novel scaffold for antitumor drug development.EBI
Eur J Med Chem 178: 705-714 (2019)
Central China Normal University
Synthesis of oxytocin derivatives lipidated via a carbonate or carbamate linkage as a long-acting therapeutic agent for social impairment-like behaviors.EBI
Bioorg Med Chem 27: 3358-3363 (2019)
Kanazawa University
Medicinal prospects of antioxidants: A review.EBI
Eur J Med Chem 178: 687-704 (2019)
Jamia Hamdard (Deemed to be University)
Discovery of 4-phenyl-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as potent and orally active PI3K/mTOR dual inhibitors.EBI
Eur J Med Chem 178: 667-686 (2019)
West China Hospital of Sichuan University
Inhibition of polypeptide N-acetyl-?-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.EBI
Bioorg Med Chem 27: 3372-3382 (2019)
Shanghai Jiao Tong University
Discovery of novel N-methyl carbazole tethered rhodanine derivatives as direct inhibitors of Mycobacterium tuberculosis InhA.EBI
Bioorg Med Chem Lett 29: 2338-2344 (2019)
University of KwaZulu-Natal (UKZN)
SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators.EBI
Bioorg Med Chem Lett 29: 2405-2409 (2019)
Novira Therapeutics
Discovery of 2,3'-diindolylmethanes as a novel class of PCSK9 modulators.EBI
Bioorg Med Chem Lett 29: 2345-2348 (2019)
University of Wisconsin
Identification of benzo[cd]indol-2(1H)-ones as novel Atg4B inhibitors via a structure-based virtual screening and a novel AlphaScreen assay.EBI
Eur J Med Chem 178: 648-666 (2019)
Institute of Advanced Chemistry of Catalonia
Discovery of SHR1653, a Highly Potent and Selective OTR Antagonist with Improved Blood-Brain Barrier Penetration.EBI
ACS Med Chem Lett 10: 996-1001 (2019)
Shanghai Hengrui Pharmaceutical CO., LTD.
Chain-Shortened Myostatin Inhibitory Peptides Improve Grip Strength in Mice.EBI
ACS Med Chem Lett 10: 985-990 (2019)
Tokyo University of Pharmacy and Life Sciences
Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3.EBI
ACS Med Chem Lett 10: 978-984 (2019)
Experimental Drug Development Centre
Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2.EBI
ACS Med Chem Lett 10: 972-977 (2019)
AstraZeneca
4-Aryl Pyrrolidines as Novel Orally Efficacious Antimalarial Agents. Part 2: 2-Aryl-EBI
ACS Med Chem Lett 10: 966-971 (2019)
Saint Louis University
Modifications at Arg and Ile Give Neurotensin(8-13) Derivatives with High Stability and Retained NTSEBI
ACS Med Chem Lett 10: 960-965 (2019)
University of Regensburg
Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors.EBI
ACS Med Chem Lett 10: 949-953 (2019)
Shanghai Hengrui Pharmaceutical Co., Ltd.
Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres.EBI
ACS Med Chem Lett 10: 941-948 (2019)
Pfizer Inc.
Synthesis and Optimization of KEBI
ACS Med Chem Lett 10: 929-935 (2019)
University of Pittsburgh
DMSO-Perturbing Assay for Identifying Promiscuous Enzyme Inhibitors.EBI
ACS Med Chem Lett 10: 923-928 (2019)
Kyushu University
Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor.EBI
ACS Med Chem Lett 10: 911-916 (2019)
Bristol-Myers Squibb
Discovery of GlyT2 Inhibitors Using Structure-Based Pharmacophore Screening and Selectivity Studies by FEP+ Calculations.EBI
ACS Med Chem Lett 10: 904-910 (2019)
The University of Texas at El Paso
Computer-Aided Selective Optimization of Side Activities of Talinolol.EBI
ACS Med Chem Lett 10: 899-903 (2019)
Goethe-University of Frankfurt
Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold.EBI
ACS Med Chem Lett 10: 893-898 (2019)
Daiichi Sankyo Co., Ltd.
Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors.EBI
ACS Med Chem Lett 10: 887-892 (2019)
Novartis Institutes for BioMedical Research
Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFREBI
ACS Med Chem Lett 10: 869-873 (2019)
East China University of Science and Technology
Extending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling.EBI
ACS Med Chem Lett 10: 863-868 (2019)
UMR CNRS 7285
Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.EBI
ACS Med Chem Lett 10: 857-862 (2019)
GlaxoSmithKline
LRRK2 Kinase Inhibitors as Possible Therapy for Parkinson's Disease and Other Neurodegenerative Disorders.EBI
ACS Med Chem Lett 10: 846-847 (2019)
Therachem Research Medilab, LLC.
Rapalogs Potential as Practical Alternatives to Rapamycin.EBI
ACS Med Chem Lett 10: 843-845 (2019)
Therachem Research Medilab, LLC.
Potential of ROCK Inhibitors as Treatment for Cardiovascular Diseases, Cancer, and More.EBI
ACS Med Chem Lett 10: 841-842 (2019)
Therachem Research Medilab, LLC.
Discovery and Biological evaluation of pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors.EBI
Bioorg Med Chem 27: 3390-3395 (2019)
East China University of Science & Technology
Synthesis and molecular modeling of novel non-sulfonylureas as hypoglycemic agents and selective ALR2 inhibitors.EBI
Bioorg Med Chem 27: 3383-3389 (2019)
Suez Canal University
Identification and characterization of potent and selective inhibitors targeting protein tyrosine phosphatase 1B (PTP1B).EBI
Bioorg Med Chem Lett 29: 2358-2363 (2019)
Zhejiang Sci-Tech University
Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer.EBI
Eur J Med Chem 178: 589-605 (2019)
University of Texas Medical Branch
Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors.EBI
Eur J Med Chem 178: 571-588 (2019)
Biological Research Centre of the Hungarian Academy of Sciences
Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38? and BRD4.EBI
Eur J Med Chem 178: 530-543 (2019)
Newcastle University
Discovery of DC_H31 as potential mutant IDH1 inhibitor through NADPH-based high throughput screening.EBI
Bioorg Med Chem 27: 3229-3236 (2019)
Huazhong Agricultural University
Dual FLT3 inhibitors: Against the drug resistance of acute myeloid leukemia in recent decade.EBI
Eur J Med Chem 178: 468-483 (2019)
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Polybenzyls from Gastrodia elata, their agonistic effects on melatonin receptors and structure-activity relationships.EBI
Bioorg Med Chem 27: 3299-3306 (2019)
Chinese Academy of Sciences
Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity.EBI
Bioorg Med Chem 27: 3339-3346 (2019)
National Institute of Advanced Industrial Science and Technology (AIST)
Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: Structure-activity relationships and mode of action studies.EBI
Eur J Med Chem 178: 500-514 (2019)
Sapienza University of Rome
Identify liver X receptor ? modulator building blocks by developing a fluorescence polarization-based competition assay.EBI
Eur J Med Chem 178: 458-467 (2019)
Sun Yat-sen University
Design, synthesis and biological evaluation of novel 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole triazole derivatives as potent TRPV1 antagonists.EBI
Eur J Med Chem 178: 433-445 (2019)
Henan University
Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile.EBI
Eur J Med Chem 178: 380-389 (2019)
Polo Universitario SS. Annunziata
Synthesis of N'-propylhydrazide analogs of hydroxamic inhibitors of histone deacetylases (HDACs) and evaluation of their impact on activities of HDACs and replication of hepatitis C virus (HCV).EBI
Bioorg Med Chem Lett 29: 2369-2374 (2019)
Russian Academy of Sciences
Discovery of 6-(2-(dimethylamino)ethyl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole-6-yl)pyrimidin-2-yl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-amine as a highly potent cyclin-dependent kinase 4/6 inhibitor for treatment of cancer.EBI
Eur J Med Chem 178: 352-364 (2019)
Shanghai Pharmaceuticals Holding Co., Ltd.
Tetrazole hybrids with potential anticancer activity.EBI
Eur J Med Chem 178: 341-351 (2019)
Henan University of Chinese Medicine
Targeting dihydrofolate reductase: Design, synthesis and biological evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as nonclassical antifolates and as potential antitumor agents.EBI
Eur J Med Chem 178: 329-340 (2019)
Hebei Medical University
Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models.EBI
J Med Chem 62: 6540-6560 (2019)
AstraZeneca
Isolation of Sesquiterpene-Amino Acid Conjugates, Onopornoids A-D, and a Flavonoid Glucoside from Onopordum alexandrinum.EBI
J Nat Prod 82: 1471-1477 (2019)
Hiroshima University
Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors.EBI
J Med Chem 62: 6575-6596 (2019)
Forma Therapeutics, Inc.
Anti-oligomerization sheet molecules: Design, synthesis and evaluation of inhibitory activities against ?-synuclein aggregation.EBI
Bioorg Med Chem 27: 3089-3096 (2019)
Zhengzhou University
Synthesis of oxadiazole-coupled-thiadiazole derivatives as a potent ?-glucuronidase inhibitors and their molecular docking study.EBI
Bioorg Med Chem 27: 3145-3155 (2019)
Imam Abdulrahman Bin Faisal University
Evaluating the effects of fluorine on biological properties and metabolic stability of some antitubulin 3-substituted 7-phenyl-pyrroloquinolinones.EBI
Eur J Med Chem 178: 297-314 (2019)
University of Padova
Histone acetyltransferase inhibitors: An overview in synthesis, structure-activity relationship and molecular mechanism.EBI
Eur J Med Chem 178: 259-286 (2019)
Sichuan University
PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets ?3?2 Nicotinic Acetylcholine Receptors.EBI
J Med Chem 62: 6262-6275 (2019)
Veterans Affairs Medical Center
Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor.EBI
J Med Chem 62: 6003-6014 (2019)
Roche Pharma Research and Early Development
Why Some Targets Benefit from beyond Rule of Five Drugs.EBI
J Med Chem 62: 10005-10025 (2019)
Boston University
Identification of Ezetimibe and Pranlukast as Pharmacological Chaperones for the Treatment of the Rare Disease Mucopolysaccharidosis Type IVA.EBI
J Med Chem 62: 6175-6189 (2019)
Universidad Nacional de Colombia
De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX.EBI
J Med Chem 62: 6377-6390 (2019)
University of Toronto
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment.EBI
Eur J Med Chem 178: 243-258 (2019)
Alma Mater Studiorum-University of Bologna
Discovery of novel Bcr-AblEBI
Eur J Med Chem 178: 232-242 (2019)
Xi'an Jiaotong University
Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.EBI
Eur J Med Chem 178: 177-194 (2019)
Fudan University
Functionalized 6-(Piperidin-1-yl)-8,9-Diphenyl Purines as Peripherally Restricted Inverse Agonists of the CB1 Receptor.EBI
J Med Chem 62: 6330-6345 (2019)
RTI International
A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia.EBI
J Med Chem 62: 6035-6046 (2019)
Universidad Complutense de Madrid
Inhibitory selectivity among class I HDACs has a major impact on inflammatory gene expression in macrophages.EBI
Eur J Med Chem 177: 457-466 (2019)
University of Groningen
Synthesis of N-hydroxycinnamoyl amide derivatives and evaluation of their anti-oxidative and anti-tyrosinase activities.EBI
Bioorg Med Chem 27: (2019)
Beijing Technology and Business University
Design, synthesis and biological evaluation of novel aryl-acrylic derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors.EBI
Bioorg Med Chem 27: 3135-3144 (2019)
Shenyang Pharmaceutical University
Improvement of Asparagine Ethylenediamines as Anti-malarial EBI
J Med Chem 62: 6137-6145 (2019)
Weill Cornell Medicine
Synthesis and anti-tumor efficacy of novel 2, 4-diarylaminopyrimidine derivatives bearing N-(3-pyridinylmethyl) urea moiety as anaplastic lymphoma kinase inhibitors.EBI
Eur J Med Chem 178: 141-153 (2019)
Peking University Health Science Center
Discovery of 1,2,4-oxadiazole-Containing hydroxamic acid derivatives as histone deacetylase inhibitors potential application in cancer therapy.EBI
Eur J Med Chem 178: 116-130 (2019)
Sichuan University and Collaborative Innovation Center of Biotherapy
Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase.EBI
Bioorg Med Chem Lett 29: 1918-1921 (2019)
Bristol-Myers Squibb
Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection.EBI
Bioorg Med Chem Lett 29: 1874-1880 (2019)
Duquesne University
Backbone modifications in peptidic inhibitors of flaviviral proteases.EBI
Bioorg Med Chem Lett 29: 1913-1917 (2019)
Heidelberg University
Naphthalene-triazolopyrimidine hybrid compounds as potential multifunctional anti-Alzheimer's agents.EBI
Bioorg Med Chem 27: 3156-3166 (2019)
Jamia Millia Islamia (Central University)
Nature-inspired pyrrolo[2,3-d]pyrimidines targeting the histamine HEBI
Bioorg Med Chem 27: 3194-3200 (2019)
Heinrich Heine University D£sseldorf
Alkylsulfonamide-containing quinazoline derivatives as potent and orally bioavailable PI3Ks inhibitors.EBI
Bioorg Med Chem 27: (2019)
Xi'an Jiaotong University
New pyrazolopyrimidine derivatives as Leishmania amazonensis arginase inhibitors.EBI
Bioorg Med Chem 27: 3061-3069 (2019)
Instituto de Tecnologia em Farmacos
Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17?-Hydroxysteroid dehydrogenases: Design, synthesis, and biological evaluation.EBI
Eur J Med Chem 178: 93-107 (2019)
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
Design, synthesis and biological evaluation of "Multi-Site"-binding influenza virus neuraminidase inhibitors.EBI
Eur J Med Chem 178: 64-80 (2019)
Shandong University
Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14.EBI
Bioorg Med Chem Lett 29: 1985-1993 (2019)
Harvard Medical School
1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacy.EBI
Eur J Med Chem 177: 448-456 (2019)
Second Military Medical University
An overview on the synthetic and medicinal perspectives of indenopyrazoles.EBI
Eur J Med Chem 178: 1-12 (2019)
CSIR-Indian Institute of Chemical Technology
Chalcone derivatives bearing chromen or benzo[f]chromen moieties: Design, synthesis, and evaluations of anti-inflammatory, analgesic, selective COX-2 inhibitory activities.EBI
Bioorg Med Chem Lett 29: 1909-1912 (2019)
Zhejiang Ocean University
Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections.EBI
Bioorg Med Chem Lett 29: 2410-2414 (2019)
GlaxoSmithKline
3H-Imidazo[4,5-b]pyridine-6-carboxylic acid derivatives as rexinoids with reduced teratogenicity.EBI
Bioorg Med Chem Lett 29: 1891-1894 (2019)
Okayama University Graduate School of Medicine
Design, synthesis and biological evaluation of 2-H pyrazole derivatives containing morpholine moieties as highly potent small molecule inhibitors of APC-Asef interaction.EBI
Eur J Med Chem 177: 425-447 (2019)
Nanjing University
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease.EBI
Eur J Med Chem 177: 414-424 (2019)
University of Bari Aldo Moro
Enhanced tumor retention of NTSR1-targeted agents by employing a hydrophilic cysteine cathepsin inhibitor.EBI
Eur J Med Chem 177: 386-400 (2019)
University of Nebraska Medical Center
Design and synthesis of novel xanthone-triazole derivatives as potential antidiabetic agents: ?-Glucosidase inhibition and glucose uptake promotion.EBI
Eur J Med Chem 177: 362-373 (2019)
Sun Yat-sen University
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.EBI
Eur J Med Chem 177: 316-337 (2019)
Institute of Cancer Research
Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model.EBI
Eur J Med Chem 177: 269-290 (2019)
Universit£ de Strasbourg
Caffeic acid phenethyl ester (CAPE)-derivatives act as selective inhibitors of acetylcholinesterase.EBI
Eur J Med Chem 177: 259-268 (2019)
Martin-Luther-University Halle-Wittenberg
Development of the "hidden" multifunctional agents for Alzheimer's disease.EBI
Eur J Med Chem 177: 247-258 (2019)
Zhejiang Academy of Medical Sciences
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction.EBI
J Med Chem 62: 5382-5403 (2019)
Zhengzhou University
Discovery of naphthacemycins as a novel class of PARP1 inhibitors.EBI
Bioorg Med Chem Lett 29: 1904-1908 (2019)
North China Pharmaceutical Group Corporation
Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase.EBI
Bioorg Med Chem Lett 29: 1962-1967 (2019)
AstraZeneca
Chemical conversion of nicotinamide into type I positive allosteric modulator of ?7 nAChRs.EBI
Bioorg Med Chem Lett 29: 1928-1933 (2019)
Peking University
Development of covalent antagonists for ?1- and ?2-adrenergic receptors.EBI
Bioorg Med Chem 27: 2959-2971 (2019)
Friedrich-Alexander Universit£t Erlangen-N£rnberg
Andrographolide: A natural product template for the generation of structurally and biologically diverse diterpenes.EBI
Eur J Med Chem 176: 513-533 (2019)
Institute of Higher Learning
Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase.EBI
Eur J Med Chem 177: 221-234 (2019)
Central University of Punjab
A novel indirubin derivative that increases somatic cell plasticity and inhibits tumorigenicity.EBI
Bioorg Med Chem 27: 2923-2934 (2019)
Gwangju Institute of Science and Technology
Discovery of conolidine derivative DS39201083 as a potent novel analgesic without mu opioid agonist activity.EBI
Bioorg Med Chem Lett 29: 1938-1942 (2019)
Daiichi Sankyo Co., Ltd.
Determining the necessity of phenyl ring ?-character in warfarin.EBI
Bioorg Med Chem Lett 29: 1954-1956 (2019)
University of Queensland
Identification and Optimization of Novel Cathepsin C Inhibitors Derived from EGFR Inhibitors.EBI
J Med Chem 62: 5901-5919 (2019)
National Institute of Biological Sciences (NIBS)
Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NADEBI
J Med Chem 62: 5844-5862 (2019)
Kyoto Prefectural University of Medicine
Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists.EBI
Bioorg Med Chem Lett 29: 1974-1980 (2019)
Janssen Research & Development, L.L.C.
Naturally occurring biflavonoids with amyloid ? aggregation inhibitory activity for development of anti-Alzheimer agents.EBI
Bioorg Med Chem Lett 29: 1994-1997 (2019)
Meiji Pharmaceutical University
Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens.EBI
Bioorg Med Chem 27: 2905-2913 (2019)
Biogen Inc.
Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.EBI
Eur J Med Chem 177: 198-211 (2019)
Anhui Medical University
Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects.EBI
Eur J Med Chem 177: 188-197 (2019)
University of Florence
Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.EBI
J Med Chem 62: 5810-5831 (2019)
KU Leuven
Discovery of ABT-957: 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability.EBI
Bioorg Med Chem Lett 29: 1968-1973 (2019)
AbbVie Deutschland GmbH & Co. KG
SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway.EBI
Eur J Med Chem 177: 171-187 (2019)
Xiamen University
Developments in the anticancer activity of structurally modified curcumin: An up-to-date review.EBI
Eur J Med Chem 177: 76-104 (2019)
Manipal Academy of Higher Education
The chemical biology of apoptosis: Revisited after 17 years.EBI
Eur J Med Chem 177: 63-75 (2019)
Tsinghua University
Tetrahydro-3-benzazepines with fluorinated side chains as NMDA and ?EBI
Eur J Med Chem 177: 47-62 (2019)
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster
Discovery of 2,4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel FAK inhibitors with antitumor and anti-angiogenesis activities.EBI
Eur J Med Chem 177: 32-46 (2019)
Peking University Health Science Center
Estrogen signaling: An emanating therapeutic target for breast cancer treatment.EBI
Eur J Med Chem 177: 116-143 (2019)
Indian Institute of Technology (BHU)
Development of novel human lactate dehydrogenase A inhibitors: High-throughput screening, synthesis, and biological evaluations.EBI
Eur J Med Chem 177: 105-115 (2019)
Hubei University of Medicine
Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK).EBI
Bioorg Med Chem Lett 29: 1727-1731 (2019)
University of North Carolina at Chapel Hill
A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78.EBI
Bioorg Med Chem Lett 29: 1689-1693 (2019)
University of Arizona
Quinoline and thiazolopyridine allosteric inhibitors of MALT1.EBI
Bioorg Med Chem Lett 29: 1694-1698 (2019)
Harvard Medical School
Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1.EBI
Bioorg Med Chem 27: 2935-2947 (2019)
Charles University
2-Phenyl-8-(1-phenylallyl)-chromenone compounds have a pan-PPAR modulator pharmacophore.EBI
Bioorg Med Chem 27: 2948-2958 (2019)
Seoul National University
Design, synthesis, and biological evaluation of novel 4-oxobenzo[d]1,2,3-triazin-benzylpyridinum derivatives as potent anti-Alzheimer agents.EBI
Bioorg Med Chem 27: 2914-2922 (2019)
University of Zanjan
Development of selective small molecule MDM2 degraders based on nutlin.EBI
Eur J Med Chem 176: 476-491 (2019)
University of Wisconsin-Madison
Recent update on anti-dengue drug discovery.EBI
Eur J Med Chem 176: 431-455 (2019)
Queensland University of Technology
Highly tunable thiosulfonates as a novel class of cysteine protease inhibitors with anti-parasitic activity against Schistosoma mansoni.EBI
Bioorg Med Chem 27: 2857-2870 (2019)
University of Glasgow
Transformation of Santonin to a Naproxen Analogue with Anti-Inflammatory Activity.EBI
J Nat Prod 82: 1710-1713 (2019)
Indian Institute of Integrative Medicine (CSIR)
Design and synthesis of a novel series of cyanoindole derivatives as potent ?-secretase modulators.EBI
Bioorg Med Chem Lett 29: 1737-1745 (2019)
Janssen Research & Development
Molecular design and anticancer activities of small-molecule monopolar spindle 1 inhibitors: A Medicinal chemistry perspective.EBI
Eur J Med Chem 175: 247-268 (2019)
Jilin University
Hydroxamic Acid Derivatives of ?-Carboline/Hydroxycinnamic Acid Hybrids Inducing Apoptosis and Autophagy through the PI3K/Akt/mTOR Pathways.EBI
J Nat Prod 82: 1442-1450 (2019)
Nantong University
Caspase-Dependent Apoptosis in Prostate Cancer Cells and Zebrafish by Corchorusoside C from Streptocaulon juventas.EBI
J Nat Prod 82: 1645-1655 (2019)
University of Illinois at Chicago
Isolation and Biological Activity of 8- Epitetrodotoxin and the Structure of a Possible Biosynthetic Shunt Product of Tetrodotoxin, Cep-226A, from the Newt Cynops ensicauda popei.EBI
J Nat Prod 82: 1656-1663 (2019)
Tohoku University
From Inhibition to Degradation: Targeting the Antiapoptotic Protein Myeloid Cell Leukemia 1 (MCL1).EBI
J Med Chem 62: 5522-5540 (2019)
University of Calgary
2D 3D