Compile Data Set for Download or QSAR
Found 252 of ec50 for UniProtKB: P34969
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM78940(METHIOTHEPIN | MLS000859918 | Methiothepin mesylat...)
Show SMILES CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1
Show InChI InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3
Affinity DataEC50:  0.600nMAssay Description:Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataEC50:  3.70nMAssay Description:Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM21392(3-(2-aminoethyl)-1H-indole-5-carboxamide | 5-CT | ...)
Show SMILES NCCc1c[nH]c2ccc(cc12)C(N)=O
Show InChI InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15)
Affinity DataEC50:  5.10nMAssay Description:Agonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataEC50:  5.40nMAssay Description:Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataEC50:  5.70nMAssay Description:Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataEC50:  5.80nMAssay Description:Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataEC50:  5.80nMAssay Description:Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataEC50:  7nMAssay Description:Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50568920(CHEMBL4846823)
Show SMILES CC1(CCCN2CCN(CC2)c2ccccn2)Cc2cc(Cl)ccc2C1=O
Show InChI InChI=1S/C22H26ClN3O/c1-22(16-17-15-18(23)6-7-19(17)21(22)27)8-4-10-25-11-13-26(14-12-25)20-5-2-3-9-24-20/h2-3,5-7,9,15H,4,8,10-14,16H2,1H3
Affinity DataEC50: >10nMAssay Description:Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataEC50:  15nMAssay Description:Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataEC50:  17nMAssay Description:Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50458557(CHEMBL4215875)
Show SMILES Cc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C14H16N2O/c1-10-2-4-11(5-3-10)14-12-6-8-15-9-7-13(12)17-16-14/h2-5,15H,6-9H2,1H3
Affinity DataEC50:  41nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50458557(CHEMBL4215875)
Show SMILES Cc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C14H16N2O/c1-10-2-4-11(5-3-10)14-12-6-8-15-9-7-13(12)17-16-14/h2-5,15H,6-9H2,1H3
Affinity DataEC50:  41nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataEC50:  48nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataEC50:  48nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50055574(CHEMBL3321798)
Show SMILES O=C1Cc2ccccc2N1CC\C=C\CCN1CC[C@H]2CCCC[C@@H]2C1
Show InChI InChI=1S/C23H32N2O/c26-23-17-20-10-5-6-12-22(20)25(23)15-8-2-1-7-14-24-16-13-19-9-3-4-11-21(19)18-24/h1-2,5-6,10,12,19,21H,3-4,7-9,11,13-18H2/b2-1+/t19-,21-/m1/s1
Affinity DataEC50:  60nMAssay Description:Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataEC50:  70nMAssay Description:Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemil...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426895(2-(Acetyloxy)ethyl 4-[2-(4-fluorophenyl)-4-oxo-1,3...)
Show SMILES Cc1cc(ccc1N1C(SCC1=O)c1ccc(F)cc1)C(=O)NS(=O)(=O)c1ccc(Cl)cc1F
Show InChI InChI=1S/C23H17ClF2N2O4S2/c1-13-10-15(22(30)27-34(31,32)20-9-5-16(24)11-18(20)26)4-8-19(13)28-21(29)12-33-23(28)14-2-6-17(25)7-3-14/h2-11,23H,12H2,1H3,(H,27,30)
Affinity DataEC50:  100nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50458554(CHEMBL4218801)
Show SMILES Clc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C13H13ClN2O/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)17-16-13/h1-4,15H,5-8H2
Affinity DataEC50:  112nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50458554(CHEMBL4218801)
Show SMILES Clc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C13H13ClN2O/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)17-16-13/h1-4,15H,5-8H2
Affinity DataEC50:  113nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50458553(CHEMBL4218672)
Show SMILES Fc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C13H13FN2O/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)17-16-13/h1-4,15H,5-8H2
Affinity DataEC50:  135nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50458553(CHEMBL4218672)
Show SMILES Fc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C13H13FN2O/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)17-16-13/h1-4,15H,5-8H2
Affinity DataEC50:  135nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50458555(CHEMBL4207884)
Show SMILES Clc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C13H14ClN3/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)16-17-13/h1-4,15H,5-8H2,(H,16,17)
Affinity DataEC50:  162nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50458555(CHEMBL4207884)
Show SMILES Clc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C13H14ClN3/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)16-17-13/h1-4,15H,5-8H2,(H,16,17)
Affinity DataEC50:  162nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50458558(CHEMBL4210782)
Show SMILES Cc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C14H17N3/c1-10-2-4-11(5-3-10)14-12-6-8-15-9-7-13(12)16-17-14/h2-5,15H,6-9H2,1H3,(H,16,17)
Affinity DataEC50:  165nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50458558(CHEMBL4210782)
Show SMILES Cc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C14H17N3/c1-10-2-4-11(5-3-10)14-12-6-8-15-9-7-13(12)16-17-14/h2-5,15H,6-9H2,1H3,(H,16,17)
Affinity DataEC50:  166nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50458550(CHEMBL4209274)
Show SMILES Fc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C13H14FN3/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)16-17-13/h1-4,15H,5-8H2,(H,16,17)
Affinity DataEC50:  186nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50458550(CHEMBL4209274)
Show SMILES Fc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C13H14FN3/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)16-17-13/h1-4,15H,5-8H2,(H,16,17)
Affinity DataEC50:  188nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426893(2-Oxopropyl 4-[2-(4-fluorophenyl)-4-oxo-1,3-thiazo...)
Show SMILES Cc1cc(ccc1N1C(SCC1=O)c1ccc(F)cc1)C(=O)NS(=O)(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C23H18BrFN2O4S2/c1-14-12-16(22(29)26-33(30,31)19-9-5-17(24)6-10-19)4-11-20(14)27-21(28)13-32-23(27)15-2-7-18(25)8-3-15/h2-12,23H,13H2,1H3,(H,26,29)
Affinity DataEC50:  200nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426890(2-(4-Pyridinyl)ethyl 4-[2-(4-fluorophenyl)-4-oxo-1...)
Show SMILES Cc1cc(ccc1N1C(SCC1=O)c1ccc(F)cc1)C(=O)NS(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C23H18F2N2O4S2/c1-14-11-16(22(29)26-33(30,31)19-4-2-3-18(25)12-19)7-10-20(14)27-21(28)13-32-23(27)15-5-8-17(24)9-6-15/h2-12,23H,13H2,1H3,(H,26,29)
Affinity DataEC50:  200nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426896(Tetrahydro-3-furanyl 4-[2-(4-fluorophenyl)-4-oxo-1...)
Show SMILES Cc1cc(ccc1N1C(SCC1=O)c1ccc(F)cc1)C(=O)NS(=O)(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C23H17F3N2O4S2/c1-13-10-15(22(30)27-34(31,32)20-9-7-17(25)11-18(20)26)4-8-19(13)28-21(29)12-33-23(28)14-2-5-16(24)6-3-14/h2-11,23H,12H2,1H3,(H,27,30)
Affinity DataEC50:  200nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426907(2-(Dimethylamino)ethyl 4-[2-(4-fluorophenyl)-4-oxo...)
Show SMILES Cc1cc(ccc1N1C(SCC1=O)c1ccc(F)cc1)-c1nnn[nH]1
Affinity DataEC50:  200nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50055575(CHEMBL3321794)
Show SMILES O=C1Cc2ccccc2N1CC\C=C\CCN1CCc2ccccc2C1
Show InChI InChI=1S/C23H26N2O/c26-23-17-20-10-5-6-12-22(20)25(23)15-8-2-1-7-14-24-16-13-19-9-3-4-11-21(19)18-24/h1-6,9-12H,7-8,13-18H2/b2-1+
Affinity DataEC50:  230nMAssay Description:Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426816(3-(2,4-Dimethoxyphenyl)-2-(4-fluorophenyl)thiazoli...)
Show SMILES COc1ccc(N2C(SCC2=O)c2ccc(F)cc2)c(OC)c1
Show InChI InChI=1S/C17H16FNO3S/c1-21-13-7-8-14(15(9-13)22-2)19-16(20)10-23-17(19)11-3-5-12(18)6-4-11/h3-9,17H,10H2,1-2H3
Affinity DataEC50:  300nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426963(3-[(5-Fluoro-2-methylphenyl)amino]-2-(4-fluorophen...)
Show SMILES Cc1cc(ccc1N1C(SCC1=O)c1ccc(F)cc1)C(=O)NC1CCC1
Show InChI InChI=1S/C21H21FN2O2S/c1-13-11-15(20(26)23-17-3-2-4-17)7-10-18(13)24-19(25)12-27-21(24)14-5-8-16(22)9-6-14/h5-11,17,21H,2-4,12H2,1H3,(H,23,26)
Affinity DataEC50:  300nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426899(1-Methoxy-2-propanyl 4-[2-(4-fluorophenyl)-4-oxo-1...)
Show SMILES Cc1cc(ccc1N1C(SCC1=O)c1ccc(F)cc1)C(=O)NS(=O)(=O)c1cccnc1
Show InChI InChI=1S/C22H18FN3O4S2/c1-14-11-16(21(28)25-32(29,30)18-3-2-10-24-12-18)6-9-19(14)26-20(27)13-31-22(26)15-4-7-17(23)8-5-15/h2-12,22H,13H2,1H3,(H,25,28)
Affinity DataEC50:  300nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50267832(1-[4-(3,4-Dihydroisoquinolin-2(1H)-yl)butyl]-1,3-d...)
Show SMILES O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1
Show InChI InChI=1S/C21H24N2O/c24-21-15-18-8-3-4-10-20(18)23(21)13-6-5-12-22-14-11-17-7-1-2-9-19(17)16-22/h1-4,7-10H,5-6,11-16H2
Affinity DataEC50:  310nMAssay Description:Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426897((2,2-Dimethyl-1,3-dioxolan-4-yl)methyl 4-[2-(4-flu...)
Show SMILES Cc1cc(c(C)cc1Cl)S(=O)(=O)NC(=O)c1ccc(N2C(SCC2=O)c2ccc(F)cc2)c(C)c1
Show InChI InChI=1S/C25H22ClFN2O4S2/c1-14-12-22(16(3)11-20(14)26)35(32,33)28-24(31)18-6-9-21(15(2)10-18)29-23(30)13-34-25(29)17-4-7-19(27)8-5-17/h4-12,25H,13H2,1-3H3,(H,28,31)
Affinity DataEC50:  400nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426840(3-(2,4-Dimethylphenyl)-2-(4-fluorophenyl)thiazolid...)
Show SMILES Cc1ccc(F)cc1C1SCC(=O)N1c1ccc(cc1C)C(O)=O
Show InChI InChI=1S/C18H16FNO3S/c1-10-3-5-13(19)8-14(10)17-20(16(21)9-24-17)15-6-4-12(18(22)23)7-11(15)2/h3-8,17H,9H2,1-2H3,(H,22,23)
Affinity DataEC50:  400nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426832(4-(2-(3,4-Difluorophenyl)-4-oxothiazolidin-3-yl)-3...)
Show SMILES CN(C)c1ccc(N2C(SCC2=O)c2ccc(F)cc2)c(C)c1
Show InChI InChI=1S/C18H19FN2OS/c1-12-10-15(20(2)3)8-9-16(12)21-17(22)11-23-18(21)13-4-6-14(19)7-5-13/h4-10,18H,11H2,1-3H3
Affinity DataEC50:  500nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426892(2-(4-Methyl-1,3-thiazol-5-yl)ethyl 4-[2-(4-fluorop...)
Show SMILES Cc1cc(ccc1N1C(SCC1=O)c1ccc(F)cc1)C(=O)NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H18ClFN2O4S2/c1-14-12-16(22(29)26-33(30,31)19-9-5-17(24)6-10-19)4-11-20(14)27-21(28)13-32-23(27)15-2-7-18(25)8-3-15/h2-12,23H,13H2,1H3,(H,26,29)
Affinity DataEC50:  500nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426859(N-(Butylsulfonyl)-4-[2-(4-fluorophenyl)-4-oxo-1,3-...)
Show SMILES Cc1ccc(F)cc1N1C(SCC1=O)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C16H12ClF2NOS/c1-9-2-4-11(18)7-14(9)20-15(21)8-22-16(20)10-3-5-12(17)13(19)6-10/h2-7,16H,8H2,1H3
Affinity DataEC50:  500nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50204672(CHEMBL3961059)
Show SMILES CNCc1ccc(Cl)c(c1)-c1ccccc1OC
Show InChI InChI=1S/C15H16ClNO/c1-17-10-11-7-8-14(16)13(9-11)12-5-3-4-6-15(12)18-2/h3-9,17H,10H2,1-2H3
Affinity DataEC50:  550nMAssay Description:Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50204672(CHEMBL3961059)
Show SMILES CNCc1ccc(Cl)c(c1)-c1ccccc1OC
Show InChI InChI=1S/C15H16ClNO/c1-17-10-11-7-8-14(16)13(9-11)12-5-3-4-6-15(12)18-2/h3-9,17H,10H2,1-2H3
Affinity DataEC50:  550nMAssay Description:Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426894(2-(Methylsulfanyl)ethyl 4-[2-(4-fluorophenyl)-4-ox...)
Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(N2C(SCC2=O)c2ccc(F)cc2)c(C)c1
Show InChI InChI=1S/C25H22FN3O5S2/c1-15-13-18(24(32)28-36(33,34)21-10-8-20(9-11-21)27-16(2)30)5-12-22(15)29-23(31)14-35-25(29)17-3-6-19(26)7-4-17/h3-13,25H,14H2,1-2H3,(H,27,30)(H,28,32)
Affinity DataEC50:  600nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426884(1-[4-(Trifluoromethyl)phenyl]ethyl 4-[2-(4-fluorop...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(N2C(SCC2=O)c2ccc(F)cc2)c(C)c1
Show InChI InChI=1S/C25H23FN2O4S2/c1-3-17-4-11-21(12-5-17)34(31,32)27-24(30)19-8-13-22(16(2)14-19)28-23(29)15-33-25(28)18-6-9-20(26)10-7-18/h4-14,25H,3,15H2,1-2H3,(H,27,30)
Affinity DataEC50:  600nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426883(1-Phenylethyl 4-[2-(4-fluorophenyl)-4-oxo-1, 3-thi...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(N2C(SCC2=O)c2ccc(F)cc2)c(C)c1
Show InChI InChI=1S/C24H21FN2O4S2/c1-15-3-10-20(11-4-15)33(30,31)26-23(29)18-7-12-21(16(2)13-18)27-22(28)14-32-24(27)17-5-8-19(25)9-6-17/h3-13,24H,14H2,1-2H3,(H,26,29)
Affinity DataEC50:  600nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM21392(3-(2-aminoethyl)-1H-indole-5-carboxamide | 5-CT | ...)
Show SMILES NCCc1c[nH]c2ccc(cc12)C(N)=O
Show InChI InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15)
Affinity DataEC50:  630nMAssay Description:Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426898(1,3-Dimethoxy-2-propanyl 4-[2-(4-fluorophenyl)-4-o...)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)NC(=O)c1ccc(N2C(SCC2=O)c2ccc(F)cc2)c(C)c1
Show InChI InChI=1S/C29H26FN3O4S2/c1-18-16-20(12-15-24(18)33-27(34)17-38-29(33)19-10-13-21(30)14-11-19)28(35)31-39(36,37)26-9-5-6-22-23(26)7-4-8-25(22)32(2)3/h4-16,29H,17H2,1-3H3,(H,31,35)
Affinity DataEC50:  700nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM426886(US10544113, No. 188 | [1-(4-Chlorophenyl)cycloprop...)
Show SMILES COc1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(N2C(SCC2=O)c2ccc(F)cc2)c(C)c1
Show InChI InChI=1S/C24H21FN2O5S2/c1-15-13-17(23(29)26-34(30,31)20-10-8-19(32-2)9-11-20)5-12-21(15)27-22(28)14-33-24(27)16-3-6-18(25)7-4-16/h3-13,24H,14H2,1-2H3,(H,26,29)
Affinity DataEC50:  700nMAssay Description:One day before the assay, CORNING black with clear flat bottom 96-well assay plates were coated with a 0.1 mg/mL Poly-L-Lysine solution. CHO-K1/MOR/G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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