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Found 1741 of ic50 for UniProtKB: P11802
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50528241(CHEMBL334285)
Affinity DataIC50:  0.00700nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50528240(CHEMBL151546)
Affinity DataIC50:  0.0260nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM448940(N-(5-(4-Ethylpiperazin-1-yl)pyridin-2-yl)-5-fluoro...)
Affinity DataIC50:  0.0700nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM448950(N-(5-(1-Ethylpiperidine-4-yl)pyridin-2-yl)-5-fluor...)
Affinity DataIC50:  0.0800nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50528239(CHEMBL148580)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM556330(N-(5-((1-ethylpiperidin-4-yl)methoxy)pyridin-2-yl)...)
Affinity DataIC50:  0.100nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM556335(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  0.110nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM556334(3-(4-((6-(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-di...)
Affinity DataIC50:  0.110nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM448926(1-(2-((5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihyd...)
Affinity DataIC50:  0.120nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM132266(US8841312, 8)
Affinity DataIC50:  0.130nMpH: 7.4 T: 2°CAssay Description:The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50455050(CHEMBL4208172 | US10696678, Example 18 | US1135117...)
Affinity DataIC50:  0.140nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM556329(N-(5-((1-ethylpiperidin-4-yl)methoxy)pyridin-2-yl)...)
Affinity DataIC50:  0.160nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM448950(N-(5-(1-Ethylpiperidine-4-yl)pyridin-2-yl)-5-fluor...)
Affinity DataIC50:  0.170nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM556328((S)—N-(5-(3-(dimethylamino)pyrrolidin-1-yl)py...)
Affinity DataIC50:  0.180nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50528238(CHEMBL4453997)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM556327((S)-(3-(dimethylamino)pyrrolidin-1-yl)(6-(5-fluoro...)
Affinity DataIC50:  0.200nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM525562(US11174252, Compound 1)
Affinity DataIC50:  0.200nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM556337(2-(4-(6-(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dih...)
Affinity DataIC50:  0.25nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM556336(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  0.25nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataIC50:  0.260nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataIC50:  0.260nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM556331(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  0.260nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50293153(CHEMBL526110 | N-(3-nitrophenyl)-4-(pyrazolo[1,5-b...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of CDK4 by radioactive glutathione plate-binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM132275(US8841312, 17)
Affinity DataIC50:  0.320nMpH: 7.4 T: 2°CAssay Description:The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM132261(US8841312, 3)
Affinity DataIC50:  0.450nMpH: 7.4 T: 2°CAssay Description:The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM525786(US11174252, Compound 474)
Affinity DataIC50:  0.5nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM525763(US11174252, Compound 450)
Affinity DataIC50:  0.5nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM525771(US11174252, Compound 458)
Affinity DataIC50:  0.5nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50455061(CHEMBL4211828 | US10696678, Example 65)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of CDK4 (unknown origin) after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM448932(5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of CDK4 (unknown origin) after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM494032(US10988476, Compound I-129)
Affinity DataIC50:  0.700nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM525710(US11174252, Compound 4)
Affinity DataIC50:  0.700nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM444593(US10662186, Compound 129)
Affinity DataIC50:  0.700nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM556326(1-(4-((6-(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-di...)
Affinity DataIC50:  0.730nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50455057(CHEMBL4215702 | US10696678, Example 20)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of CDK4 (unknown origin) after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM435712(US10570141, Example 1)
Affinity DataIC50:  0.800nMAssay Description:LANCE method of PerkinElmer Inc. was used in the assay, and recombinant CDK4/CyclinD3 (Item No.: 04-105) and CDK6/CyclinD3 (Item No.: 04-107) kinases...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM132293(US8841312, 36)
Affinity DataIC50:  0.830nMpH: 7.4 T: 2°CAssay Description:The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM444563(US10662186, Compound 82 | US10988476, Compound I-8...)
Affinity DataIC50:  0.860nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM444563(US10662186, Compound 82 | US10988476, Compound I-8...)
Affinity DataIC50:  0.860nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM444595(US10662186, Compound 131 | US10988476, Compound I-...)
Affinity DataIC50:  0.910nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM444569(US10662186, Compound 88 | US10988476, Compound I-8...)
Affinity DataIC50:  0.910nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM444595(US10662186, Compound 131 | US10988476, Compound I-...)
Affinity DataIC50:  0.910nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM444569(US10662186, Compound 88 | US10988476, Compound I-8...)
Affinity DataIC50:  0.910nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM132263(US8841312, 5)
Affinity DataIC50:  0.910nMpH: 7.4 T: 2°CAssay Description:The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM444568(US10662186, Compound 87 | US10988476, Compound I-8...)
Affinity DataIC50:  0.920nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM444568(US10662186, Compound 87 | US10988476, Compound I-8...)
Affinity DataIC50:  0.920nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM444566(US10662186, Compound 85 | US10988476, Compound I-8...)
Affinity DataIC50:  0.940nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM444566(US10662186, Compound 85 | US10988476, Compound I-8...)
Affinity DataIC50:  0.940nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM132281(US8841312, 24)
Affinity DataIC50:  0.940nMpH: 7.4 T: 2°CAssay Description:The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM444567(US10662186, Compound 86 | US10988476, Compound I-8...)
Affinity DataIC50:  0.960nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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