Compile Data Set for Download or QSAR
maximum 50k data
Found 44 Enz. Inhib. hit(s) with all data for entry = 50016046
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591659(CHEMBL5196373)
Affinity DataKi: <1.20nMAssay Description:Binding affinity to Mcl-1 (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50330247(6,6',7,7'-Tetrahydroxy-5,5'-diisopropyl-3,3'-dimet...)
Affinity DataKi:  35nMAssay Description:Binding affinity to Bcl-2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50303503(CHEMBL4160782 | US10858316, Compound SF-5-141)
Affinity DataKi:  120nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591668(CHEMBL5198484)
Affinity DataKi:  153nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50303352(CHEMBL4164057)
Affinity DataKi:  180nMAssay Description:Binding affinity to Mcl-1 (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50013858(CHEMBL3265291)
Affinity DataKi:  180nMAssay Description:Binding affinity to Mcl-1 (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591660(CHEMBL3818394)
Affinity DataKi:  200nMAssay Description:Binding affinity to Mcl-1 (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50581328(CHEMBL5090868)
Affinity DataKi:  298nMAssay Description:Binding affinity to Mcl-1 (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50303139(CHEMBL4171930)
Affinity DataKi:  320nMAssay Description:Binding affinity to Mcl-1 (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591661(CHEMBL5186810)
Affinity DataKi:  530nMAssay Description:Binding affinity to Mcl-1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50330247(6,6',7,7'-Tetrahydroxy-5,5'-diisopropyl-3,3'-dimet...)
Affinity DataKi:  660nMAssay Description:Binding affinity to Bcl-XL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50266958(CHEMBL4077940)
Affinity DataKi:  1.79E+3nMAssay Description:Binding affinity to Bak/Mcl-1 (unknown origin) protein protein interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50303215(CHEMBL4167501)
Affinity DataKi:  2.90E+3nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50308110((S,Z)-2-(5-((6-(2,3-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKi:  6.90E+3nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591666(CHEMBL5207001)
Affinity DataKi:  7.77E+3nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50308111((S,Z)-2-(5-((6-(3,4-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKi:  8.00E+3nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591659(CHEMBL5196373)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to Bcl-2 (unknown origin) assessed as inhibition constant by fluorescence polarisation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591659(CHEMBL5196373)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to Bcl-xL (unknown origin) assessed as inhibition constant by fluorescence polarisation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591662(CHEMBL5208863)
Affinity DataKi:  1.14E+4nMAssay Description:Binding affinity to Mcl-1/Bak protein protein interaction (unknown origin) assessed as inhibition constant by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591661(CHEMBL5186810)
Affinity DataKi:  1.50E+4nMAssay Description:Binding affinity to Bcl-2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50330247(6,6',7,7'-Tetrahydroxy-5,5'-diisopropyl-3,3'-dimet...)
Affinity DataKi:  2.50E+4nMAssay Description:Binding affinity to Mcl-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKi:  4.40E+4nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591667(CHEMBL5170330)
Affinity DataKi:  2.61E+5nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM203869(7-(3-((4-Borono-3-formylphenoxy)methyl)-1,5-dimeth...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of Mcl-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM203875(7-(3-((4-Borono-3-formylphenoxy)methyl)-1,5-dimeth...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of Mcl-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM203870(7-(3-((3-Acetyl-4-boronophenoxy)methyl)-1,5-dimeth...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of Mcl-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM203876(Mcl-1 inhibitor 12)
Affinity DataIC50:  6nMAssay Description:Inhibition of Mcl-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50303987(CHEMBL4163417)
Affinity DataIC50:  162nMAssay Description:Inhibition of Mcl-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM31809(Apogossypol derivative, 8k)
Affinity DataIC50:  230nMAssay Description:Inhibition of Mcl-1/Bak (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591663(CHEMBL5203189)
Affinity DataIC50:  280nMAssay Description:Inhibition of Mcl-1/Bak (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591664(CHEMBL5182721)
Affinity DataIC50:  620nMAssay Description:Inhibition of Mcl-1/Bak (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50013890(CHEMBL3265288)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of Mcl-1 (unknown origin) measured after 5 mins by spectramax M5 microplate reader methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50013890(CHEMBL3265288)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of FITC-MCL-1 SAHBa binding to recombinant MCL-1 (172 - 327 residues) (unknown origin) by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50266958(CHEMBL4077940)
Affinity DataIC50:  1.02E+4nMAssay Description:Inhibition of Bak/Mcl-1 (unknown origin) protein protein interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591665(CHEMBL5181238)
Affinity DataIC50:  4.40E+4nMAssay Description:Inhibition of Mcl-1/Bak (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibition of Mcl-1/Bak (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50330250(5,5'-Dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl...)
Affinity DataIC50:  1.22E+5nMAssay Description:Inhibition of Mcl-1/Bak (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50308110((S,Z)-2-(5-((6-(2,3-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKd:  250nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50505362(CHEMBL4470807)
Affinity DataKd:  430nMAssay Description:Binding affinity to wildtype Mcl-1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591669(CHEMBL5192932)
Affinity DataKd:  150nMAssay Description:Binding affinity to wildtype Mcl-1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591670(CHEMBL5193943)
Affinity DataKd:  150nMAssay Description:Binding affinity to wildtype Mcl-1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKd:  8.40E+4nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591659(CHEMBL5196373)
Affinity DataKd:  0.190nMAssay Description:Binding affinity to Mcl-1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50308111((S,Z)-2-(5-((6-(3,4-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair
In DepthDetails PubMed