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Report error Found 980 Enz. Inhib. hit(s) with Target = 'Calpain-1 catalytic subunit'
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM535882(US11242312, Example 3)
Affinity DataIC50: 0.00800nMAssay Description:Activity of Calpain 1 was measured by using Calpain-Glo Protease kit from Promega. Assays were run in 384-well black plates with clear bottom. 5 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
US Patent

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM535880(US11242312, Example 1)
Affinity DataIC50: 0.0300nMAssay Description:Activity of Calpain 1 was measured by using Calpain-Glo Protease kit from Promega. Assays were run in 384-well black plates with clear bottom. 5 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
US Patent

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50053813((1-{1-Benzyl-2-oxo-2-[3-(3,4,4a,8a-tetrahydro-1H-i...)
Affinity DataKi:  0.220nMAssay Description:Inhibition of the cysteine protease human Calpain 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50053865((3-Methyl-1-{1-[3-(3,4,4a,8a-tetrahydro-1H-isoquin...)
Affinity DataKi:  0.310nMAssay Description:Inhibition of the cysteine protease human Calpain 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50053851((3-Methyl-1-{1-[3-(3,4,4a,8a-tetrahydro-2H-quinoli...)
Affinity DataKi:  0.370nMAssay Description:Inhibition of the cysteine protease human Calpain 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50053800((1-{1-Benzyl-2-oxo-2-[3-(3,4,4a,8a-tetrahydro-2H-q...)
Affinity DataKi:  0.380nMAssay Description:Inhibition of the cysteine protease human Calpain 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50065404((R)-N-((S)-5-Benzenesulfonylamino-1-formyl-pentyl)...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50142284(2-Ethyl-1,1-dioxo-1,2,3,4,6,7-hexahydro-5,8-dioxa-...)
Affinity DataIC50: 2.10nMAssay Description:Inhibitory activity tested against human calpain 1 in Molt-4 cells (intact human T-cell leukemia cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM535881(US11242312, Example 2)
Affinity DataIC50: 2.20nMAssay Description:Activity of Calpain 1 was measured by using Calpain-Glo Protease kit from Promega. Assays were run in 384-well black plates with clear bottom. 5 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
US Patent

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50245477(CHEMBL4073900)
Affinity DataIC50: 3nMAssay Description:Inhibition of human calpain 1 protease using Ac-LLY-AFC as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50290289((S)-2-[(S)-2-((S)-2-Acetylamino-4-methyl-pentanoyl...)
Affinity DataKi:  3.40nMAssay Description:Equilibrium dissociation constant for the inhibition of human Mu-calpain was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50065398((R)-3-Benzyloxy-N-[(S)-1-(4-benzyloxy-benzyl)-2-ox...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291234([(S)-1-((S)-1-Formyl-2-methyl-propylcarbamoyl)-3-m...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291219([(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-2,2-...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291225({(S)-1-[(R)-1-((R)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50105236(6-Chloro-2-methyl-1,1-dioxo-1,2,3,4-tetrahydro-1la...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity towards human calpain IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50084655([(S)-1-((S)-1-Formyl-pentylcarbamoyl)-3-methyl-but...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50142302(6-Chloro-2-ethyl-1,1-dioxo-1,2,3,4-tetrahydro-1lam...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory activity against human calpain I; Not determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50101321([(S)-1-((S)-1-Benzyl-2-benzyloxycarbamoyl-2-oxo-et...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant Calpain 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50105229(2-Methyl-1,1-dioxo-1,2,6,7-tetrahydro-5,8-dioxa-1l...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity towards human calpain IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50065401((S)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzylsulfanyl-...)
Affinity DataKi:  6nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291188(((S)-1-{(R)-1-[(S)-1-((S)-1-Formyl-3-methyl-butylc...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50112833(N-(1-Benzyl-2-carbamoyl-2-oxo-ethyl)-2-(2-naphthal...)
Affinity DataKi:  6nMAssay Description:Inhibition of calpain, using human mu-calpain isolated from erythrocytes and Suc-Leu-Tyr-AMC as the fluorogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50084655([(S)-1-((S)-1-Formyl-pentylcarbamoyl)-3-methyl-but...)
Affinity DataKi:  7nMAssay Description:The binding affinity against calpain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50105231(2-Ethyl-1,1-dioxo-1,2,3,4,6,7-hexahydro-5,8-dioxa-...)
Affinity DataIC50: 7nMAssay Description:In vitro inhibitory activity against human calpain 1 in Molt-4 cells (intact human T-cell leukemia cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50105241(6,7-Dichloro-2-methyl-1,1-dioxo-1,2,3,4-tetrahydro...)
Affinity DataIC50: 7nMAssay Description:Inhibitory activity towards human calpain IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50066991((R)-2-(2-Benzyloxycarbonylamino-4-methyl-pentanoyl...)
Affinity DataIC50: 7nMAssay Description:inhibitory activity measured against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50142283(1,1-Dioxo-1,2,3,4-tetrahydro-1lambda*6*-benzo[e][1...)
Affinity DataIC50: 7nMAssay Description:In vitro inhibitory activity against human calpain 1 in Molt-4 cells (intact human T-cell leukemia cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50105231(2-Ethyl-1,1-dioxo-1,2,3,4,6,7-hexahydro-5,8-dioxa-...)
Affinity DataIC50: 7nMAssay Description:Inhibitory activity towards human calpain IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291222({(S)-1-[(S)-1-(4-Benzyloxy-benzyl)-2-oxo-ethylcarb...)
Affinity DataIC50: 7nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM535883(US11242312, Example 4)
Affinity DataIC50: 7.10nMAssay Description:Activity of Calpain 1 was measured by using Calpain-Glo Protease kit from Promega. Assays were run in 384-well black plates with clear bottom. 5 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
US Patent

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50124010(2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-me...)
Affinity DataIC50: 7.5nMAssay Description:In vitro inhibition of porcine mu-calpain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Rat)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50114340(N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal | (S...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50105244(2-Ethyl-1,1-dioxo-1,2,6,7-tetrahydro-5,8-dioxa-1la...)
Affinity DataIC50: 8nMAssay Description:In vitro inhibitory activity against human calpain 1 in Molt-4 cells (intact human T-cell leukemia cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50065407((R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-met...)
Affinity DataKi:  8nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291228([(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-3-me...)
Affinity DataIC50: 8nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50080227(N-((S)-1-Benzyl-2-{2-[5-(3-cyano-phenyl)-thiophene...)
Affinity DataKi:  8nMAssay Description:Inhibitory activity against recombinant human calpain IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Pig)
University of Tennessee Health Science Center

LigandPNGBDBM23865(3-[(2S)-2-[1-(9H-fluoren-9-yl)acetamido]-4-methylp...)
Affinity DataKi:  8nM ΔG°:  -45.7kJ/molepH: 7.4 T: 2°CAssay Description:Assays were initiated by addition of CaCl2, and the increase in fluorescence (ex @370 nm, em @440 nm) was monitored. MDL28170 and buffer with 2% DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2008
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50258392(CHEMBL4092996)
Affinity DataKi:  8nMAssay Description:Inhibition of human erythrocytes calpain-1 using Suc-Leu-Tyr-AMC as substrate by kinetic fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50014577(CHEMBL286722 | benzyl (S)-3-methyl-1-oxo-1-((S)-1-...)
Affinity DataKi:  8nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50105244(2-Ethyl-1,1-dioxo-1,2,6,7-tetrahydro-5,8-dioxa-1la...)
Affinity DataIC50: 8nMAssay Description:Inhibitory activity towards human calpain IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291192([(S)-1-[(R)-1-((R)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 8nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50291236([(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-3-me...)
Affinity DataIC50: 8nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50128678(N-(1-Carbamoyl-2-phenyl-ethyl)-2-(2-naphthalen-1-y...)
Affinity DataKi:  8.40nMAssay Description:Inhibitory activity against human Calpain 1 isolated from erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50065412((R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-(th...)
Affinity DataKi:  9nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50276901(CHEMBL4167219)
Affinity DataKi:  9nMAssay Description:Inhibition of human erythrocytes mu-calpain using SucLeu-Tyr-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2020
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50065399((R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-met...)
Affinity DataKi:  9nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50065411((R)-N-((S)-1-Benzyl-2-oxo-ethyl)-2-methanesulfonyl...)
Affinity DataKi:  9nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50092301(1-(Benzo[b]thiophene-2-carbonyl)-piperidine-4-carb...)
Affinity DataKi:  9nMAssay Description:Inhibition of Suc-Leu-Tyr-AMC binding to human mu-calpain from erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Landsteiner Genmed

US Patent
LigandPNGBDBM50065396((R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-eth...)
Affinity DataKi:  9nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
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