Affinity DataIC50: 1.40nMAssay Description:Inhibition of Ser 209 phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin) in HCT-116 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assayMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 51nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assayMore data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 95nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 117nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 125nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin) in HCT-116 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMpH: 7.0Assay Description:Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMpH: 7.0Assay Description:Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...More data for this Ligand-Target Pair
Affinity DataIC50: 700nMpH: 7.0Assay Description:Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...More data for this Ligand-Target Pair
Affinity DataIC50: 720nMAssay Description:Inhibition of P32-[alpha-GTP] cap radiolabelled RNA binding to recombinant eIF4E (unknown origin) assessed as decrease in cross linked RNA-eIF4E comp...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 800nMpH: 7.0Assay Description:Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...More data for this Ligand-Target Pair
Affinity DataIC50: 970nMpH: 7.0Assay Description:Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E [28-217](Homo sapiens (Human))
Pic Therapeutics
US Patent
Pic Therapeutics
US Patent
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds (3.43 mM stock in DMSO) were diluted 2-fold in series in DMSO (10 concentration points). Compound solutions (1.2 μl/well) were ad...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E [28-217](Homo sapiens (Human))
Pic Therapeutics
US Patent
Pic Therapeutics
US Patent
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds (3.43 mM stock in DMSO) were diluted 2-fold in series in DMSO (10 concentration points). Compound solutions (1.2 μl/well) were ad...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E [28-217](Homo sapiens (Human))
Pic Therapeutics
US Patent
Pic Therapeutics
US Patent
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds (3.43 mM stock in DMSO) were diluted 2-fold in series in DMSO (10 concentration points). Compound solutions (1.2 μl/well) were ad...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E [28-217](Homo sapiens (Human))
Pic Therapeutics
US Patent
Pic Therapeutics
US Patent
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds (3.43 mM stock in DMSO) were diluted 2-fold in series in DMSO (10 concentration points). Compound solutions (1.2 μl/well) were ad...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E [28-217](Homo sapiens (Human))
Pic Therapeutics
US Patent
Pic Therapeutics
US Patent
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds (3.43 mM stock in DMSO) were diluted 2-fold in series in DMSO (10 concentration points). Compound solutions (1.2 μl/well) were ad...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E [28-217](Homo sapiens (Human))
Pic Therapeutics
US Patent
Pic Therapeutics
US Patent
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds (3.43 mM stock in DMSO) were diluted 2-fold in series in DMSO (10 concentration points). Compound solutions (1.2 μl/well) were ad...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E [28-217](Homo sapiens (Human))
Pic Therapeutics
US Patent
Pic Therapeutics
US Patent
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds (3.43 mM stock in DMSO) were diluted 2-fold in series in DMSO (10 concentration points). Compound solutions (1.2 μl/well) were ad...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E [28-217](Homo sapiens (Human))
Pic Therapeutics
US Patent
Pic Therapeutics
US Patent
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds (3.43 mM stock in DMSO) were diluted 2-fold in series in DMSO (10 concentration points). Compound solutions (1.2 μl/well) were ad...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E [28-217](Homo sapiens (Human))
Pic Therapeutics
US Patent
Pic Therapeutics
US Patent
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds (3.43 mM stock in DMSO) were diluted 2-fold in series in DMSO (10 concentration points). Compound solutions (1.2 μl/well) were ad...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E [28-217](Homo sapiens (Human))
Pic Therapeutics
US Patent
Pic Therapeutics
US Patent
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds (3.43 mM stock in DMSO) were diluted 2-fold in series in DMSO (10 concentration points). Compound solutions (1.2 μl/well) were ad...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E [28-217](Homo sapiens (Human))
Pic Therapeutics
US Patent
Pic Therapeutics
US Patent
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds (3.43 mM stock in DMSO) were diluted 2-fold in series in DMSO (10 concentration points). Compound solutions (1.2 μl/well) were ad...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E [28-217](Homo sapiens (Human))
Pic Therapeutics
US Patent
Pic Therapeutics
US Patent
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds (3.43 mM stock in DMSO) were diluted 2-fold in series in DMSO (10 concentration points). Compound solutions (1.2 μl/well) were ad...More data for this Ligand-Target Pair
