Compile Data Set for Download or QSAR
Found 28 Enz. Inhib. hit(s) with all data for entry = 50040183
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390557(CHEMBL2069346)
Show SMILES FC(F)(F)c1ccnc(Nc2cccc(n2)-c2cccc(c2)N2CCNCC2)c1
Show InChI InChI=1S/C21H20F3N5/c22-21(23,24)16-7-8-26-20(14-16)28-19-6-2-5-18(27-19)15-3-1-4-17(13-15)29-11-9-25-10-12-29/h1-8,13-14,25H,9-12H2,(H,26,27,28)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390556(CHEMBL2069345)
Show SMILES FC(F)(F)c1ccnc(Nc2cccc(n2)-c2ccnc(c2)N2CCNCC2)c1
Show InChI InChI=1S/C20H19F3N6/c21-20(22,23)15-5-7-25-18(13-15)28-17-3-1-2-16(27-17)14-4-6-26-19(12-14)29-10-8-24-9-11-29/h1-7,12-13,24H,8-11H2,(H,25,27,28)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390568(CHEMBL2069358)
Show SMILES O=C(Cc1cccnc1)Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C25H25N9O/c35-25(12-18-2-1-4-27-16-18)31-20-14-21(32-22(15-20)33-23-17-28-6-7-29-23)19-3-5-30-24(13-19)34-10-8-26-9-11-34/h1-7,13-17,26H,8-12H2,(H2,29,31,32,33,35)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390563(CHEMBL2069352)
Show SMILES O=C(Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1)C1CCNCC1
Show InChI InChI=1S/C24H29N9O/c34-24(17-1-4-25-5-2-17)30-19-14-20(31-21(15-19)32-22-16-27-7-8-28-22)18-3-6-29-23(13-18)33-11-9-26-10-12-33/h3,6-8,13-17,25-26H,1-2,4-5,9-12H2,(H2,28,30,31,32,34)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390561(CHEMBL2069350)
Show SMILES CNc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C19H22N8/c1-20-15-11-16(25-17(12-15)26-18-13-22-4-5-23-18)14-2-3-24-19(10-14)27-8-6-21-7-9-27/h2-5,10-13,21H,6-9H2,1H3,(H2,20,23,25,26)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390560(CHEMBL2069349)
Show SMILES Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C18H20N8/c19-14-10-15(24-16(11-14)25-17-12-21-3-4-22-17)13-1-2-23-18(9-13)26-7-5-20-6-8-26/h1-4,9-12,20H,5-8H2,(H3,19,22,24,25)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390564(CHEMBL2069353)
Show SMILES CC(=O)N1CCC(CC1)C(=O)Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C26H31N9O2/c1-18(36)34-10-3-19(4-11-34)26(37)31-21-15-22(32-23(16-21)33-24-17-28-6-7-29-24)20-2-5-30-25(14-20)35-12-8-27-9-13-35/h2,5-7,14-17,19,27H,3-4,8-13H2,1H3,(H2,29,31,32,33,37)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390566(CHEMBL2069355)
Show SMILES O=C(Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1)c1cccnc1
Show InChI InChI=1S/C24H23N9O/c34-24(18-2-1-4-26-15-18)30-19-13-20(31-21(14-19)32-22-16-27-6-7-28-22)17-3-5-29-23(12-17)33-10-8-25-9-11-33/h1-7,12-16,25H,8-11H2,(H2,28,30,31,32,34)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390567(CHEMBL2069357)
Show SMILES Cc1cc(C(=O)Nc2cc(Nc3cnccn3)nc(c2)-c2ccnc(c2)N2CCNCC2)n(C)n1
Show InChI InChI=1S/C24H26N10O/c1-16-11-20(33(2)32-16)24(35)29-18-13-19(30-21(14-18)31-22-15-26-5-6-27-22)17-3-4-28-23(12-17)34-9-7-25-8-10-34/h3-6,11-15,25H,7-10H2,1-2H3,(H2,27,29,30,31,35)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390562(CHEMBL2069351)
Show SMILES Oc1ccc(CNc2cc(Nc3cnccn3)nc(c2)-c2ccnc(c2)N2CCNCC2)cc1
Show InChI InChI=1S/C25H26N8O/c34-21-3-1-18(2-4-21)16-30-20-14-22(31-23(15-20)32-24-17-27-7-8-28-24)19-5-6-29-25(13-19)33-11-9-26-10-12-33/h1-8,13-15,17,26,34H,9-12,16H2,(H2,28,30,31,32)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390569(CHEMBL2069359)
Show SMILES OC(=O)c1ccc(cc1)C(=O)Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C26H24N8O3/c35-25(17-1-3-18(4-2-17)26(36)37)31-20-14-21(32-22(15-20)33-23-16-28-7-8-29-23)19-5-6-30-24(13-19)34-11-9-27-10-12-34/h1-8,13-16,27H,9-12H2,(H,36,37)(H2,29,31,32,33,35)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390573(CHEMBL2069356)
Show SMILES O=C(Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1)c1cncnc1
Show InChI InChI=1S/C23H22N10O/c34-23(17-12-26-15-27-13-17)30-18-10-19(31-20(11-18)32-21-14-25-3-4-28-21)16-1-2-29-22(9-16)33-7-5-24-6-8-33/h1-4,9-15,24H,5-8H2,(H2,28,30,31,32,34)
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390571(CHEMBL2069360)
Show SMILES OC(=O)c1ccc(cn1)C(=O)Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C25H23N9O3/c35-24(17-1-2-19(25(36)37)30-14-17)31-18-12-20(32-21(13-18)33-22-15-27-5-6-28-22)16-3-4-29-23(11-16)34-9-7-26-8-10-34/h1-6,11-15,26H,7-10H2,(H,36,37)(H2,28,31,32,33,35)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390552(CHEMBL2069341)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2ccnc(c2)N2CCNCC2)c1
Show InChI InChI=1S/C20H22N6/c1-15-5-7-22-19(13-15)25-18-4-2-3-17(24-18)16-6-8-23-20(14-16)26-11-9-21-10-12-26/h2-8,13-14,21H,9-12H2,1H3,(H,22,24,25)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390555(CHEMBL2069344)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2ccnc(c2)N2CCCNCC2)c1
Show InChI InChI=1S/C21H24N6/c1-16-6-9-23-20(14-16)26-19-5-2-4-18(25-19)17-7-10-24-21(15-17)27-12-3-8-22-11-13-27/h2,4-7,9-10,14-15,22H,3,8,11-13H2,1H3,(H,23,25,26)
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390565(CHEMBL2069354)
Show SMILES O=C(Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1)c1ccccc1
Show InChI InChI=1S/C25H24N8O/c34-25(18-4-2-1-3-5-18)30-20-15-21(31-22(16-20)32-23-17-27-8-9-28-23)19-6-7-29-24(14-19)33-12-10-26-11-13-33/h1-9,14-17,26H,10-13H2,(H2,28,30,31,32,34)
Affinity DataIC50: 28nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390559(CHEMBL2069348)
Show SMILES C1CN(CCN1)c1cccc(c1)-c1cccc(Nc2cnccn2)n1
Show InChI InChI=1S/C19H20N6/c1-3-15(13-16(4-1)25-11-9-20-10-12-25)17-5-2-6-18(23-17)24-19-14-21-7-8-22-19/h1-8,13-14,20H,9-12H2,(H,22,23,24)
Affinity DataIC50: 43nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390558(CHEMBL2069347)
Show SMILES C1CN(CCN1)c1cc(ccn1)-c1cccc(Nc2cnccn2)n1
Show InChI InChI=1S/C18H19N7/c1-2-15(23-16(3-1)24-17-13-20-6-7-21-17)14-4-5-22-18(12-14)25-10-8-19-9-11-25/h1-7,12-13,19H,8-11H2,(H,21,23,24)
Affinity DataIC50: 62nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390570(CHEMBL2069337)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2cccc(NCCN)c2)c1
Show InChI InChI=1S/C19H21N5/c1-14-8-10-22-19(12-14)24-18-7-3-6-17(23-18)15-4-2-5-16(13-15)21-11-9-20/h2-8,10,12-13,21H,9,11,20H2,1H3,(H,22,23,24)
Affinity DataIC50: 91nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390554(CHEMBL2069343)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2ccnc(c2)N2CCC(N)CC2)c1
Show InChI InChI=1S/C21H24N6/c1-15-5-9-23-20(13-15)26-19-4-2-3-18(25-19)16-6-10-24-21(14-16)27-11-7-17(22)8-12-27/h2-6,9-10,13-14,17H,7-8,11-12,22H2,1H3,(H,23,25,26)
Affinity DataIC50: 114nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390548(CHEMBL2069340)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2cccc(CCN)c2)c1
Show InChI InChI=1S/C19H20N4/c1-14-9-11-21-19(12-14)23-18-7-3-6-17(22-18)16-5-2-4-15(13-16)8-10-20/h2-7,9,11-13H,8,10,20H2,1H3,(H,21,22,23)
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390549(CHEMBL2069336)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2ccnc(NCCN)c2)c1
Show InChI InChI=1S/C18H20N6/c1-13-5-8-21-18(11-13)24-16-4-2-3-15(23-16)14-6-9-20-17(12-14)22-10-7-19/h2-6,8-9,11-12H,7,10,19H2,1H3,(H,20,22)(H,21,23,24)
Affinity DataIC50: 200nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390553(CHEMBL2069342)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2ccnc(c2)N2CCC(N)C2)c1
Show InChI InChI=1S/C20H22N6/c1-14-5-8-22-19(11-14)25-18-4-2-3-17(24-18)15-6-9-23-20(12-15)26-10-7-16(21)13-26/h2-6,8-9,11-12,16H,7,10,13,21H2,1H3,(H,22,24,25)
Affinity DataIC50: 450nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390551(CHEMBL2069334)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2ccnc(NCCCN)c2)c1
Show InChI InChI=1S/C19H22N6/c1-14-6-10-23-19(12-14)25-17-5-2-4-16(24-17)15-7-11-22-18(13-15)21-9-3-8-20/h2,4-7,10-13H,3,8-9,20H2,1H3,(H,21,22)(H,23,24,25)
Affinity DataIC50: 528nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390547(CHEMBL2069339)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2cccc(CN)c2)c1
Show InChI InChI=1S/C18H18N4/c1-13-8-9-20-18(10-13)22-17-7-3-6-16(21-17)15-5-2-4-14(11-15)12-19/h2-11H,12,19H2,1H3,(H,20,21,22)
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390550(CHEMBL2069335)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2ccnc(NCCO)c2)c1
Show InChI InChI=1S/C18H19N5O/c1-13-5-7-20-18(11-13)23-16-4-2-3-15(22-16)14-6-8-19-17(12-14)21-9-10-24/h2-8,11-12,24H,9-10H2,1H3,(H,19,21)(H,20,22,23)
Affinity DataIC50: 1.87E+3nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390572(CHEMBL2069361)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2cccnc2)c1
Show InChI InChI=1S/C16H14N4/c1-12-7-9-18-16(10-12)20-15-6-2-5-14(19-15)13-4-3-8-17-11-13/h2-11H,1H3,(H,18,19,20)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50390546(CHEMBL2069338)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2cccc(N)c2)c1
Show InChI InChI=1S/C17H16N4/c1-12-8-9-19-17(10-12)21-16-7-3-6-15(20-16)13-4-2-5-14(18)11-13/h2-11H,18H2,1H3,(H,19,20,21)
Affinity DataIC50: 3.24E+3nMAssay Description:Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assayMore data for this Ligand-Target Pair