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203 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase.EBI
Second University Of Naples
Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.EBI
Bhupat And Jyoti Mehta School Of Biosciences
Humudifucol and Bioactive Prenylated Polyphenols from Hops (Humulus lupulus cv."Cascade").EBI
University Of Naples Federico Ii
4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP).EBI
Gazi University
A potent and selective inhibitor targeting human and murine 12/15-LOX.EBI
University Of California
Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition.EBI
Second University Of Naples
Synthesis and biological evaluation of novel 5-hydroxylaminoisoxazole derivatives as lipoxygenase inhibitors and metabolism enhancing agents.EBI
Lomonosov Moscow State University
Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors.EBI
University Of Ferrara
Synthesis and biological evaluation of novel myrtucommulones and structural analogues that target mPGES-1 and 5-lipoxygenase.EBI
University Of Jena
Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol.EBI
University Of Innsbruck
Myxochelins target human 5-lipoxygenase.EBI
Leibniz-Institute For Natural Product Research And Infection Biology
Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes.EBI
University Of Naples
Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity.EBI
Boehringer Ingelheim (Canada)
1,3,4-Thiadiazoles: a potent multi targeted pharmacological scaffold.EBI
University Of Mississippi
SAR-studies of¿-secretase modulators with PPAR¿-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.EBI
Goethe-University Frankfurt
Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARa/¿ activation and dual 5-LO/mPGES-1 inhibition.EBI
Goethe-University Frankfurt
Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism.EBI
Goethe-University Frankfurt
Inhibitory and mechanistic investigations of oxo-lipids with human lipoxygenase isozymes.EBI
University Of California
Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy.EBI
Goethe-University Frankfurt
SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.EBI
University Jena
Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E(2) synthase-1.EBI
Peking University
Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase.EBI
University Of Naples
Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase.EBI
Friedrich-Schiller-University
Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.EBI
Harvard Medical School
Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors.EBI
Peking University
One-step semisynthesis of oleacein and the determination as a 5-lipoxygenase inhibitor.EBI
University Of Athens
Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase.EBI
National Institutes Of Health
Lead modification: amino acid appended indoles as highly effective 5-LOX inhibitors.EBI
Guru Nanak Dev University
Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase.EBI
University Of Salerno
Inhibition of LOX by flavonoids: a structure-activity relationship study.EBI
Universidade Do Porto
Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities.EBI
Medical University Of South Carolina
Exploring the chemical space of multitarget ligands using aligned self-organizing maps.EBI
Goethe University
Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection.EBI
University Of Groningen
Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.EBI
Goethe-University Frankfurt
Investigating the selectivity of metalloenzyme inhibitors.EBI
University Of California San Diego
Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation.EBI
Pfizer
Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase.EBI
Goethe-University Frankfurt
N-1, C-3 substituted indoles as 5-LOX inhibitors--in vitro enzyme immunoaasay, mass spectral and molecular docking investigations.EBI
Guru Nanak Dev University
Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.EBI
Ici Pharmaceuticals Group
Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases.EBI
Groningen Research Institute Of Pharmacy
Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX.EBI
Eberhard-Karls University
Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid.EBI
Zafes/Liff/Goethe University Frankfurt
Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.EBI
Peking University
Charting, navigating, and populating natural product chemical space for drug discovery.EBI
Max Planck Institute Of Molecular Physiology
Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.EBI
University Of Innsbruck
Synthesis of benzo-annulated tryptanthrins and their biological properties.EBI
Yeungnam University
Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors.EBI
University Of Salerno
Dual-target virtual screening by pharmacophore elucidation and molecular shape filtering.EBI
TBA
Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors.EBI
Zafes/Liff/Osf Goethe-University Frankfurt
A class of 5-benzylidene-2-phenylthiazolinones with high potency as direct 5-lipoxygenase inhibitors.EBI
Goethe-University Frankfurt
Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines.EBI
Universit£
Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.EBI
University Of California Santa Cruz
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.EBI
Eberhard Karls University Tuebingen
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.EBI
University Of Oxford
Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein.EBI
Merck Frosst Centre For Therapeutic Research
Designed multiple ligands. An emerging drug discovery paradigm.EBI
Organon Laboratories
Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry.EBI
The Scripps Research Institute
Heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic acids as leukotriene biosynthesis inhibitors.EBI
Abbott Laboratories
Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010.EBI
Merck Frosst Centre For Therapeutic Research
Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors.EBI
Abbott Laboratories
Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.EBI
Merck Frosst Centre For Therapeutic Research
(R)-(+)-N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl- 2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor.EBI
Abbott Laboratories
Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase: use of the hydroxyurea moiety as a replacement for hydroxamic acid.EBI
R. W. Johnson Pharmaceutical Research Institute
Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors.EBI
Ici Pharmaceuticals Group
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.EBI
Wyeth-Ayerst Research
A study of novel antiallergic agents with eosinophilic infiltration inhibiting action.EBI
Tokushima Bunri University
Synthesis and anti-inflammatory activity of chalcone derivatives.EBI
Universidad De Valencia
SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase.EBI
Zafes/Liff/Osf Goethe-University Frankfurt
Structure based drug design, synthesis and evaluation of 4-(benzyloxy)-1-phenylbut-2-yn-1-ol derivatives as 5-lipoxygenase inhibitors.EBI
University Of Hyderabad
5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.EBI
Amira Pharmaceuticals
Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase.EBI
Universiti Putra Malaysia
Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.EBI
National Taiwan University
Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils.EBI
Gazi University
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.EBI
National Human Genome Research Institute
Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase.EBI
Bristol-Myers Squibb Research And Development
Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1.EBI
Eberhard Karls University Tuebingen
Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1).EBI
University Of Innsbruck
Natural compound cudraflavone B shows promising anti-inflammatory properties in vitro.EBI
University Of Veterinary And Pharmaceutical Sciences Brno
Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents.EBI
University Of Salerno
A novel class of dual mPGES-1/5-LO inhibitors based on thea-naphthyl pirinixic acid scaffold.EBI
Goethe-University Frankfurt
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.EBI
University Of California
Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: discovery of MK-5286.EBI
Merck Frosst Centre For Therapeutic Research
Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.EBI
National Human Genome Research Institute
Design, synthesis, and biological evaluation of prenylated chalcones as 5-LOX inhibitors.EBI
University Of Hyderabad
Bioactivity-guided mapping and navigation of chemical space.EBI
Institut FüR Molekulare Physiologie
Derivatives of schisandrin with increased inhibitory potential on prostaglandin E(2) and leukotriene B(4) formation in vitro.EBI
University Of Graz
Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.EBI
National Taiwan University
Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation.EBI
Karl-Franzens-Universit£T Graz
 
O-alkylcarboxylate oxime and N-hydroxyurea analogs of substituted indole leukotriene biosynthesis inhibitorsEBI
TBA
 
2,4,5- triarylimidazole inhibitors of IL-1 biosynthesisEBI
TBA
 
Benzoxepin and benzothiepin derivatives as potent, orally active inhibitors of 5-lipoxygenaseEBI
TBA
 
Design of pyrrolo-1,4-benzoxazine derivatives as inhibitors of 5-lipoxygenase and PAF antagonists with anthihistaminic propertiesEBI
TBA
 
Synthesis and Biological Evaluation of New Leukotriene Analogs.EBI
TBA
 
Synthesis and biological evaluation of new arachidonic acid analogsEBI
TBA
 
Design and synthesis of achiral 5-lipoxygenase inhibitors employing the cyclobutyl groupEBI
TBA
 
Justicidin E: A new leukotriene biosynthesis inhibitor.EBI
TBA
 
Structure-activity relationships of the pyridazinone series of 5-lipoxygenase inhibitorsEBI
TBA
 
1-Phenyl-[2H]-tetrahydropyridazin-3-one, A-53612, a selective orally active 5-lipoxygenase inhibitorEBI
TBA
 
Phenothiazine and phenoxazine derivatives of nafazatrom. In vitro evaluation as 5-lipoxygenase and iron-dependent lipid peroxidation inhibitors.EBI
TBA
 
Enzymic and nonenzymic lipid peroxidation: inhibition by substituted phenoxazinesEBI
TBA
Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters.EBI
Université
Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults.EBI
National Institute Of Advanced Industrial Science And Technology (Aist)
Highly functionalized 7-azaindoles as selective PPAR gamma modulators.EBI
Merck Research Laboratories
Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: a novel class of 5-lipoxygenase inhibitors.EBI
University Of Alberta
Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives.EBI
Universidad De Murcia
Workup-dependent formation of 5-lipoxygenase inhibitory boswellic acid analogues.EBI
Institute Of Pharmaceutical Sciences
5-Lipoxygenase and cyclooxygenase-1 inhibitory active compounds from Atractylodes lancea.EBI
Heinrich-Heine-UniversitäT DüSseldorf
Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening.EBI
Johann Wolfgang Goethe-UniversitäT
Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti.EBI
Tahitian Noni International
Discovery of a Novel Class of d-Amino Acid Oxidase Inhibitors Using the Schrödinger Computational Platform.EBI
Schr£Dinger
Novel potent benzimidazole-based microsomal prostaglandin EEBI
Gazi University
Substituted coumarins as potent 5-lipoxygenase inhibitors.EBI
Merck Frosst Centre For Therapeutic Research
Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease.EBI
Central University Of Punjab
Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.EBI
"G. D'Annunzio" University Of Chieti-Pescara
5-Lipoxygenase inhibitors: convenient synthesis of 4-[3-(4-heterocyclylphenylthio)phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide analogues.EBI
Pfizer
Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: EBI
University Federico Ii Of Naples
Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors.EBI
Universitat De Barcelona
5-Lipoxygenase inhibition by N-hydroxycarbamates in dual-function compounds.EBI
Ucb Pharma
New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy.EBI
Université
Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity.EBI
Ucb Pharma
Structure-Activity Relationship Studies of New Sinapic Acid Phenethyl Ester Analogues Targeting the Biosynthesis of 5-Lipoxygenase Products: The Role of Phenolic Moiety, Ester Function, and Bioisosterism.EBI
Universit£
From the Design to the EBI
Unitat Associada Al Csic
Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways.EBI
University Of Salerno
5-lipoxygenase inhibitors with histamine H(1) receptor antagonist activity.EBI
Ucb Pharma
Docking and mutagenesis studies lead to improved inhibitor development of ML355 for human platelet 12-lipoxygenase.EBI
University Of California Santa Cruz
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation.EBI
University Of Innsbruck
4-[5-Fluoro-3-[4-(2-methyl-1H-imidazol-1-yl)benzyloxy]phenyl]-3,4,5,6- tetrahydro-2H-pyran-4-carboxamide, an orally active inhibitor of 5-lipoxygenase with improved pharmacokinetic and toxicology characteristics.EBI
Pfizer
Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.EBI
University Of California Santa Cruz
Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.EBI
Consejo Superior De Investigaciones Cient�Ficas (Iqm-Csic)
Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase.EBI
Goethe-University Of Frankfurt
Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents.EBI
University Of Malakand
Synthesis, inhibitory activity and in silico docking of dual COX/5-LOX inhibitors with quinone and resorcinol core.EBI
Institute Of Experimental Botany Of The Czech Academy Of Sciences
Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors.EBI
Univ Angers
Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors.EBI
Cairo University
Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.EBI
Laboratoires Innothera
Immobilized Metal Affinity Chromatography as a Drug Discovery Platform for Metalloenzyme Inhibitors.EBI
The University Of Sydney
Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation.EBI
Universidade Federal Do Rio De Janeiro
Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.EBI
Osaka University
Myxochelin- and Pseudochelin-Derived Lipoxygenase Inhibitors from a Genetically Engineered EBI
Institute For Natural Product Research And Infection Biology
Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells.EBI
Universit£
Design, synthesis and identification of novel coumaperine derivatives for inhibition of human 5-LOX: Antioxidant, pseudoperoxidase and docking studies.EBI
Vellore Institute Of Technology
Role of sulphur-heterocycles in medicinal chemistry: An update.EBI
Maharaja Ranjit Singh Punjab Technical University
Human disorders associated with inflammation and the evolving role of natural products to overcome.EBI
University Of Delhi
5-Lipoxygenase as a drug target: A review on trends in inhibitors structural design, SAR and mechanism based approach.EBI
School Of Advanced Sciences
Structure-activity relationship and synthetic methodologies of ?-santonin derivatives with diverse bioactivities: A mini-review.EBI
Shanghai Ocean University
1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview.EBI
Chinese Academy Of Sciences
Synthesis, Biological Evaluation and Structure-Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors.EBI
University Of Innsbruck
Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors.EBI
University Of Campania "L. Vanvitelli
Quinolines as potent 5-lipoxygenase inhibitors: synthesis and biological profile of L-746,530.EBI
Merck Frosst Centre For Therapeutic Research
New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position.EBI
Procter & Gamble Pharmaceuticals
Prenylated Stilbenoids Affect Inflammation by Inhibiting the NF-?B/AP-1 Signaling Pathway and Cyclooxygenases and Lipoxygenase.EBI
Czech Academy Of Sciences
New cyclooxygenase-2/5-lipoxygenase inhibitors. 1. 7-tert-buty1-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: discovery and variation of the 5-keto substituent.EBI
Procter & Gamble Pharmaceuticals
Novel indole-2-carboxamide and cycloalkeno[1,2-b]indole derivatives. Structure-activity relationships for high inhibition of human LDL peroxidation.EBI
Université
Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.EBI
Abbott Laboratories
5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.EBI
Abbott Laboratories
Chalcone-Thiazole Hybrids: Rational Design, Synthesis, and Lead Identification against 5-Lipoxygenase.EBI
Indian Institute Of Technology
Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816.EBI
Merck Frosst Centre For Therapeutic Research
Conformational analysis of 5-lipoxygenase inhibitors: role of the substituents in chiral recognition and on the active conformations of the (methoxyalkyl)thiazole and methoxytetrahydropyran series.EBI
Astrazeneca
Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors.EBI
Ciba-Geigy
Antipsoriatic anthrones with modulated redox properties. 2. Novel derivatives of chrysarobin and isochrysarobin--antiproliferative activity and 5-lipoxygenase inhibition.EBI
UniversitäT Regensburg
Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid.EBI
Merck Frosst Centre For Therapeutic Research
Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids.EBI
Merck Frosst Centre For Therapeutic Research
(6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase.EBI
Merckle
Synthesis, structure-activity relationships, and pharmacological evaluation of pyrrolo[3,2,1-ij]quinoline derivatives: potent histamine and platelet activating factor antagonism and 5-lipoxygenase inhibitory properties. Potential therapeutic application in asthma.EBI
Solvay Pharma
Derivatives of 2-[[N-(Aminocarbonyl)-N-hydroxyamino]methyl]-1,4- benzodioxan as orally active 5-lipoxygenase inhibitors.EBI
Ciba-Geigy
Chiral dioxolane inhibitors of leukotriene biosynthesis: structure-activity relationships and syntheses using asymmetric dihydroxylation.EBI
Zeneca Pharmaceuticals
Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase.EBI
Merck Frosst Centre For Therapeutic Research
Synthesis and 5-lipoxygenase inhibitory activities of eicosanoid compounds.EBI
TBA
Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin EEBI
Goethe-University Frankfurt
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.EBI
Consejo Superior De Investigaciones Cient�Ficas (Iqm-Csic)
Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation.EBI
Universit£
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.EBI
The Czech Academy Of Sciences
Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase.EBI
Vellore Institute Of Technology
Phenylephrine derivatives as leukotriene D4 antagonists.EBI
Wyeth Laboratories
Identification of multi-target inhibitors of leukotriene and prostaglandin EEBI
Gazi University
Acetohydroxamic acids as potent, selective, orally active 5-lipoxygenase inhibitors.EBI
Wellcome Research Laboratories
MK-7622: A First-in-Class MEBI
Merck
Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1.EBI
Glenmark Pharmaceuticals
Recent advances in the search for novel 5-lipoxygenase inhibitors for the treatment of asthma.EBI
University Of Campania "Luigi Vanvitelli
Tailoring the Substitution Pattern on 1,3,5-Triazine for Targeting Cyclooxygenase-2: Discovery and Structure-Activity Relationship of Triazine-4-Aminophenylmorpholin-3-one Hybrids that Reverse Algesia and Inflammation in Swiss Albino Mice.EBI
TBA
Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224.EBI
Merck Frosst Canada
Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis.EBI
Rorer Central Research
Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acryl amides.EBI
Dainippon Pharmaceutical
Studies on hindered phenols and analogues. 2. 1,3-Benzoxathioles having SRS-A inhibiting activity.EBI
Sankyo
Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes.EBI
Molecular Therapeutics
Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 1. Initial structure-activity relationships.EBI
Rorer Central Research
Effect of structure on potency and selectivity in 2,6-disubstituted 4-(2-arylethenyl)phenol lipoxygenase inhibitors.EBI
Boehringer Ingelheim Pharmaceuticals
Syntheses of 5,7,8- and 5,6,7-trioxygenated 3-alkyl-3',4'-dihydroxyflavones and their inhibitory activities against arachidonate 5-lipoxygenase.EBI
University Of Tokushima
4-hydroxythiazole inhibitors of 5-lipoxygenase.EBI
Abbott Laboratories
Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones.EBI
University Of Athens
Discovery of an Inhibitor of the Proteasome Subunit Rpn11.EBI
University Of California San Diego
Recent synthetic and medicinal perspectives of tryptanthrin.EBI
Indo-Soviet Friendship College Of Pharmacy (Isfcp)
(Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity.EBI
Ici Pharmaceuticals Group
The Bibenzyl Canniprene Inhibits the Production of Pro-Inflammatory Eicosanoids and Selectively Accumulates in Some Cannabis sativa Strains.EBI
Universit£
Synthesis and biological evaluation of 4-imidazolylflavans as nonsteroidal aromatase inhibitors.BDB
BiomolÉCules Et Cibles Cellulaires Tumorales
Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors.BDB
University Of Luxembourg