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ChEMBL_2021479 (CHEMBL4675292) Inhibition of human CSE by methylene blue method ChEMBL_2021482 (CHEMBL4675295) Inhibition of human CBS by methylene blue method ChEMBL_2021484 (CHEMBL4675297) Inhibition of CBS (unknown origin) by methylene blue method PARN Activity Assay The enzymatic activity was determined by the methylene blue assay. ChEMBL_2275079 Inhibition of mouse IDO1 using L-tryptophan as substrate by methylene blue dye based analysis ChEMBL_2275077 Inhibition of human IDO1 using L-tryptophan as substrate by methylene blue dye based spectrometric method ChEMBL_1546970 (CHEMBL3748073) Inhibition of human recombinant IDO1 expressed in yeast IS20-2B using tryptophan as substrate by methylene blue/ascorbate assay ChEMBL_2275081 Inhibition of human recombinant IDO1 using L-tryptophan as substrate incubated for 45 mins by methylene blue dye based microplate reader analysis ChEMBL_2026055 (CHEMBL4679868) Inhibition of human IDO1 expressed in Escherichia coli Rosetta using tryptophan as substrate incubated for 1 hr by methylene blue based assay ChEMBL_2026056 (CHEMBL4679869) Inhibition of human TDO expressed in Escherichia coli Rosetta using tryptophan as substrate incubated for 1 hr by methylene blue based assay ChEMBL_2172849 (CHEMBL5057983) Inhibition of IDO1 (unknown origin) assessed as reduction in kynurenine formation using L-tryptophan as substrate by methylene blue reagent based assay ChEMBL_2172850 (CHEMBL5057984) Inhibition of IDO2 (unknown origin) assessed as reduction in kynurenine formation using L-tryptophan as substrate by methylene blue reagent based assay ChEMBL_1546964 (CHEMBL3748067) Inhibition of N-terminal His-tagged human recombinant IDO1 expressed in Escherichia coli using L-tryptophan as substrate by methylene blue/ascorbate assay ChEMBL_1546968 (CHEMBL3748071) Inhibition of N-terminal His-tagged human recombinant IDO1 expressed in Escherichia coli using D-tryptophan as substrate by methylene blue/ascorbate assay ChEMBL_1779685 (CHEMBL4236677) Inhibition of IDO1 (unknown origin) assessed as reduction in N'-formlylkynurenine formation using D-Tryptophan as substrate in presence of aspartate and methylene blue ChEMBL_1800464 (CHEMBL4272756) Inhibition of ARTD10 (unknown origin)-induced cell death expressed in human HeLa cells after 10 days by methylene blue staining based colony formation assay ChEMBL_2158972 (CHEMBL5043722) Inhibition of human IDO1 protein assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate by methylene blue reagent based enzymatic assay ChEMBL_2275084 Inhibition of human IDO1 expressed in Escherichia coli using L-tryptophan as substrate incubated for 30 mins by methylene blue dye based microplate reader analysis ChEMBL_1709125 (CHEMBL4119174) Inhibition of ascorbic acid/methylene blue activated recombinant human IDO expressed in Escherichia coli using L-Tryptophan as substrate after 60 mins by spectrophotometric method ChEMBL_2275095 Binding affinity to human recombinant IDO1 assessed as inhibition constant using L-tryptophan as substrate incubated for 10 mins by methylene blue dye based HPLC analysis ChEMBL_2155052 (CHEMBL5039712) Agonist activity at TLR2 in HEK-Blue cells incubated for 24 hrs by Quanti-Blue based SEAP assay ChEMBL_2283991 Agonist activity at human TLR7 in HEK-Blue hTLR7 cells incubated for 24 hrs by quanti-blue reagent based analysis ChEMBL_2283992 Agonist activity at human TLR8 in HEK-Blue hTLR8 cells incubated for 24 hrs by quanti-blue reagent based analysis ChEMBL_2283994 Agonist activity at human TLR7 in HEK-Blue hTLR7 cells incubated for 18 hrs by quanti-blue reagent based analysis ChEMBL_2372008 Inhibition of TYK2 in HEK-Blue IL-23 cells assessed as reduction in SEAP reporter gene expression by Quanti-blue assay ChEMBL_2104319 (CHEMBL4812822) Inhibition of recombinant human IDO1 assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 45 mins by methylene blue reagent based assay ChEMBL_2193095 (CHEMBL5105455) Agonist activity at human TLR2/TLR6 expressed in HEK-Blue hTLR2-TLR6 cells by SEAP reporter gene based Quanti-blue assay ChEMBL_2349277 Agonist activity at human TLR7 in HEK-Blue hTLR7 cells incubated for 18 hrs by QUANTI-Blue reagent based SEAP reporter assay ChEMBL_1853418 (CHEMBL4354042) Inhibition of recombinant human IDO1 expressed in Escherichia coli BL21 cells using L-tryptophan as substrate incubated for 30 mins by methylene blue dye based microplate reader analysis ChEMBL_2158975 (CHEMBL5043725) Inhibition of recombinant human TDO2 protein assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 1 hr by methylene blue reagent based assay ChEMBL_2266639 Agonist activity at TLR2 in HEK-Blue hTLR2 cells ChEMBL_2267954 Antagonist activity at human TLR8 stably expressed in human HEK-Blue hTLR8 cells incubated for 24 hrs by Quanti-Blue based SEAP assay ChEMBL_2323860 Inhibition of IL-6 stimulated STAT3 phosphorylation in HEK-Blue IL-6 cells incubated for 20 to 24 hrs by QUANTI-Blue assay ChEMBL_1855445 (CHEMBL4356174) Inhibition of N-terminal His-tagged human IDO1 expressed in Escherichia coli assessed as reduction in conversion of D-tryptophan to N-formyl kynurenine by methylene blue dye assay ChEMBL_2275085 Inhibition of human N-terminal his6-tagged IDO1 expressed in Escherichia coli BL21 using L-tryptophan as substrate incubated for 90 mins by methylene blue dye based microplate reader analysis ChEMBL_2033604 (CHEMBL4687762) Inhibition of TLR8 in HEK-Blue hTLR8 assessed as reduction in SEAP production incubated for 20 to 24 hrs by Quanti-Blue assay ChEMBL_2349467 Agonist activity at human TLR7 in HEK-Blue hTLR7 cells harboring SEAP reporter transgene incubated for 18 hrs by quanti-blue reagent based assay ChEMBL_1855238 (CHEMBL4355967) Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity by methylene blue staining based by Plaque reduction assay ChEMBL_2122594 (CHEMBL4831827) Inhibition of human N-terminal His-tagged IDO1 expressed in Escherichia coli assessed as formation of N'-formyl-kynurenine using D-tryptophan as a substrate by methylene blue based assay ChEMBL_2516994 Inhibition of human IGF-IR expressed in mouse NWT-21 cells assessed as inhibition of proliferative capacity incubated for 72 hrs in presence of serum by methylene blue staining based assay ChEMBL_811525 (CHEMBL2013879) Inhibition of integrin alpha4 beta7 receptor in mouse TK1 cells assessed as inhibition of Mn2+-activated cell adhesion to mouse MAdCAM-1-Fc after 1 hr using methylene blue staining ChEMBL_2331738 Antagonist activity at TLR1/TLR2 in HEK-Blue hTLR2 cells ChEMBL_563949 (CHEMBL965857) Inhibition of rat liver FAS by Coomassie blue staining ChEMBL_1846389 (CHEMBL4346930) Agonist activity at human TLR2 expressed in HEK-Blue cells assessed as activation of SEAP incubated for 24 hrs by quanti-blue SEAP assay ChEMBL_2486531 Agonist activity at human TLR7 expressed in HEK-Blue hTLR7 cells harboring SEAP reporter gene incubated for 18 hrs by quanti-blue reagent based assay ChEMBL_2486532 Agonist activity at human TLR8 expressed in HEK-Blue hTLR8 cells harboring SEAP reporter gene incubated for 18 hrs by quanti-blue reagent based assay ChEMBL_2275091 Inhibition of human recombinant N-terminal his6-tagged IDO1 expressed in Escherichia coli BL21 using L-tryptophan as substrate incubated for 1 hr by methylene blue dye based UV-Vis spectrophotometer analysis ChEMBL_2099864 (CHEMBL4808260) Activation of human STING (139 to 379 residues) expressed in THP1-Blue ISG cells incubated for 24 hrs by quanti-blue SEAP reporter gene assay ChEMBL_2371987 Inhibition of JAK2/TYK2 in HEK-Blue IL-23 cells assessed as reduction in SEAP reporter gene expression incubated for 21 hrs by Quanti-blue assay ChEMBL_2432378 Agonist activity at human TLR7 in HEK-Blue hTLR7 cells assessed as increase in inducible SEAP level incubated for overnight by QUANTI-Blue reagent based assay ChEMBL_2432379 Agonist activity at human TLR8 in HEK-Blue hTLR8 cells assessed as increase in inducible SEAP level incubated for overnight by QUANTI-Blue reagent based assay ChEMBL_2104315 (CHEMBL4812818) Inhibition of recombinant human IDO1 expressed in Escherichia coli EC538 assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 30 mins by methylene blue reagent based assay ChEMBL_2274186 Agonist activity at human TLR8 transfected in HEK-Blue hTLR8 cells ChEMBL_2274187 Agonist activity at human TLR7 transfected in HEK-Blue hTLR7 cells ChEMBL_2331732 Binding affinity to human TLR8 expressed in HEK-Blue hTLR8 cells ChEMBL_2354127 Agonist activity at STING in PMA-differentiated wildtype human THP1-Blue ISG cells harboring IRF-inducible SEAP reporter construct incubated for 24 hrs by QUANTI-Blue assay ChEMBL_2359163 Agonist activity at TLR7 in human Ramos-blue cells assessed as increase in NFkappaB activation incubated for 72 hrs by quanti-blue/SEAP reporter gene based assay ChEMBL_2102219 (CHEMBL4810615) Inhibition of recombinant human TDO2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate measured after 40 mins by methylene blue reagent based spectrophotometry ChEMBL_2104316 (CHEMBL4812819) Inhibition of recombinant human IDO1 expressed in Escherichia coli EC538 assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 30 mins by methylene blue reagent based concurrent assay ChEMBL_2104318 (CHEMBL4812821) Inhibition of recombinant human TDO2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 30 mins by methylene blue reagent based assay ChEMBL_2362494 Agonist activity at human TLR4 in human HEK-Blue hTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti-blue assay ChEMBL_2362502 Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti-blue assay ChEMBL_1797288 (CHEMBL4269405) Agonist activity at TLR7 (unknown origin) expressed in HEK-Blue cells ChEMBL_1797289 (CHEMBL4269406) Agonist activity at TLR8 (unknown origin) expressed in HEK-Blue cells ChEMBL_614225 (CHEMBL1106928) Inhibition of recombinant human DHODH by using blue indicator dye DCIP ChEMBL_2104317 (CHEMBL4812820) Inhibition of recombinant human TDO2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 30 mins by methylene blue reagent based concurrent assay ChEMBL_2210630 (CHEMBL5123579) Inhibition of PARP10 in human HeLa cells assessed as increase in cell colonies incubated for 10 days with replacement with fresh medium for every 4 days by methylene blue dye based colony formation assay ChEMBL_2349429 Inhibition of TYK2 in HEK-Blue IL-23 cells pretreated for 60 mins followed by IL-23 stimulation for 22 to 24 hrs by Quanti-Blue based SEAP assay ChEMBL_2349430 Inhibition of TYK2 in HEK-Blue alpha/beta cells pretreated for 60 mins followed by IFN-alpha stimulation for 16 to 18 hrs by Quanti-Blue based SEAP assay ChEMBL_1760480 (CHEMBL4195488) Inhibition of TNFR in TLR null HEK-blue cells assessed as decrease in TNFalpha-stimulated NF-kappaB activation-mediated SEAP production after 24 hrs by Quanti-blue-based assay ChEMBL_1760482 (CHEMBL4195490) Inhibition of PKC in TLR null HEK-blue cells assessed as inhibition of PMA-induced NF-kappaB activation-mediated SEAP production after 24 hrs by Quanti-blue-based assay ChEMBL_2034105 (CHEMBL4688263) Inhibition of exogenous human TNFalpha in HEK-Blue-CD40L cells assessed as reduction in TNF-alpha-induced NFkappaB activation incubated for 18 hrs by quanti-blue based SEAP assay ChEMBL_2377983 Agonist activity at TLR7 in human HEK-Blue hTLR7 cells assessed as activation of NF-kappaB incubated for 20 hrs by SEAP reporter gene based quanti-blue reagent spectrophotometric analysis ChEMBL_2440613 Agonist activity at TLR7 in HEK-Blue hTLR7 cells expressing NF-kappaB/AP-1 inducible SEAP assessed as increase in SEAP activity incubated for 24 hrs by QUANTI-Blue assay ChEMBL_2440616 Agonist activity at TLR8 in HEK-Blue hTLR8 cells expressing NF-kappaB/AP-1 inducible SEAP assessed as increase in SEAP activity incubated for 24 hrs by QUANTI-Blue assay ChEMBL_1855396 (CHEMBL4356125) Inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as reduction in conversion of L-tryptophan to N-formyl kynurenine using L-tryptophan as substrate after 30 mins by methylene blue assay ChEMBL_1760481 (CHEMBL4195489) Inhibition of IL1R in TLR null HEK-blue cells assessed as decrease in IL-1beta-stimulated NF-kappaB activation-mediated SEAP production after 24 hrs by Quanti-blue-based assay ChEMBL_1760483 (CHEMBL4195491) Inhibition of PKC in HEK-blue cells expressing human TLR7 assessed as inhibition of PMA-induced NF-kappaB activation-mediated SEAP production after 24 hrs by Quanti-blue-based assay ChEMBL_1858564 (CHEMBL4359293) Inhibition of human TLR8 expressed in HEK-Blue cells assessed as inhibition of R848-induced NF-kappaB activation measured after 24 hrs by quanti-blue based SEAP reporter gene assay ChEMBL_1858565 (CHEMBL4359294) Inhibition of human TLR8 expressed in HEK-Blue cells assessed as inhibition of ssRNA06-induced NF-kappaB activation measured after 24 hrs by quanti-blue based SEAP reporter gene assay ChEMBL_1624965 (CHEMBL3867377) Inhibition of N-terminus 6xHis-tagged human IDO1 expressed in Escherichia coli M15 using L-tryptophan as substrate preincubated for 1 hr measured after 15 mins in presence of bovine liver and methylene blue by spectrophotometric analysis ChEMBL_1624966 (CHEMBL3867378) Inhibition of N-terminus 6xHis-tagged human IDO1 expressed in Escherichia coli M15 using L-tryptophan as substrate preincubated for 1 hr measured after 15 mins in presence of bovine liver and methylene blue by HPLC analysis ChEMBL_2437614 Agonist activity at human TLR7 expressed in HEK-Blue hTLR8 cells by spectrophotometric analysis ChEMBL_1860787 (CHEMBL4361643) Antagonist activity at human TLR7 expressed in HEK-blue cells assessed as inhibition of CL264-induced NFkappaB activation after 24 hrs using qunati-blue reagent by SEAP reporter gene-based spectrophotometric method ChEMBL_1624973 (CHEMBL3867385) Inhibition of N-terminal 6xHis-tagged human TDO expressed in Escherichia cli Rosetta (DE3) pLysS using L-tryptophan as substrate preincubated for 1 hr measured after 15 mins in presence of bovine liver and methylene blue by spectrophotometric analysis ChEMBL_1855394 (CHEMBL4356123) Inhibition of recombinant human IDO1 expressed in Escherichia coli BL21 cells assessed as reduction in conversion of L-tryptophan to N-formyl kynurenine using L-tryptophan as substrate after 30 mins by methylene blue dye based microplate reader analysis ChEMBL_2025658 (CHEMBL4679471) Inhibition of human TLR9 expressed in HEK-Blue cells assessed as inhibition of ODN2006-induced NF-kappaB and AP-1 activation measured after 20 hrs by quanti-blue based SEAP reporter gene assay ChEMBL_2025659 (CHEMBL4679472) Inhibition of human TLR8 expressed in HEK-Blue cells assessed as inhibition of R848-induced NF-kappaB and AP-1 activation measured after 20 hrs by quanti-blue based SEAP reporter gene assay ChEMBL_2025660 (CHEMBL4679473) Inhibition of human TLR7 expressed in HEK-Blue cells assessed as inhibition of R848-induced NF-kappaB and AP-1 activation measured after 20 hrs by quanti-blue based SEAP reporter gene assay ChEMBL_2215183 (CHEMBL5128315) Inhibition of human TLR4 expressed in HEK293-Blue hTLR4 cells assessed as SEAP expression ChEMBL_2313246 Agonist activity at human TLR7 expressed in HEK-Blue hTLR7 cells by reporter gene assay ChEMBL_2313247 Agonist activity at human TLR8 expressed in HEK-Blue hTLR8 cells by reporter gene assay ChEMBL_2230377 (CHEMBL5144149) Inhibition of recombinant human IDO1 expressed in Escherichia coli assessed as reduction in formation of N-formylkynurenine by measuring apparent inhibition constant using L-tryptophan as substrate preincubated with compound for 5 mins followed substrate addition by ascorbate/methylene blue assay ChEMBL_2327258 Inhibition of TLR3 in HEK-Blue hTLR3 assessed as inhibition of poly (I:C) induced SEAP signalling ChEMBL_1904129 (CHEMBL4406351) Agonist activity at human TLR7 expressed in HEK-Blue cells assessed as induction of NFkappaB activation by measuring increase in SEAP level after overnight incubation using qunati-blue reagent by SEAP reporter gene-based spectrophotometric method ChEMBL_2127307 (CHEMBL4836652) Inhibition of human TLR7 expressed in HEK293-Blue cells assessed as inhibition of R848-induced NF-kappaB/AP-1 activation measured after 20 hrs using quanti-blue as substrate by SEAP reporter gene based spectrophotometry assay ChEMBL_2127308 (CHEMBL4836653) Inhibition of human TLR8 expressed in HEK293-Blue cells assessed as inhibition of R848-induced NF-kappaB/AP-1 activation measured after 20 hrs using quanti-blue as substrate by SEAP reporter gene based spectrophotometry assay ChEMBL_2127309 (CHEMBL4836654) Inhibition of human TLR9 expressed in HEK293-Blue cells assessed as inhibition of R848-induced NF-kappaB/AP-1 activation measured after 20 hrs using quanti-blue as substrate by SEAP reporter gene based spectrophotometry assay ChEMBL_1807623 (CHEMBL4306982) Antagonist activity at human TLR8 expressed in HEK-Blue cells assessed as inhibition of CL075-induced NF-kappaB activation incubated for 1 hr followed by CL075-stimulation and measured after 24 hrs by quanti-blue SEAP assay ChEMBL_2033597 (CHEMBL4687755) Agonist activity at TLR2 in HEK-Blue hTLR2 cells assessed as NF-kappaB activation preincubated for 24 hrs followed by replacement of medium containing compound and measured after 0.5 to 1 hrs by Quanti-blue SEAP assay ChEMBL_2195675 (CHEMBL5108191) Antagonist activity at human TLR2 in HEK-Blue hTLR2 cells assessed as inhibition of Pam3CSK4-induced receptor activation preincubated with Pam3CSK4 followed by compound addition and measured 24 hrs by Quanti-Blue based SEAP reporter gene assay ChEMBL_2195676 (CHEMBL5108192) Antagonist activity at human TLR4 in HEK-Blue hTLR4 cells assessed as inhibition of LPS-induced receptor activation preincubated with LPS followed by compound addition and measured 24 hrs by Quanti-Blue based SEAP reporter gene assay ChEMBL_1629931 (CHEMBL3872637) Inhibition of recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate after 30 mins in presence of catalase by methylene blue dye based assay ChEMBL_1456651 (CHEMBL3370251) Agonist activity at human GABAAalpha1beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay ChEMBL_1456653 (CHEMBL3370253) Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay ChEMBL_1456657 (CHEMBL3370257) Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay ChEMBL_1456659 (CHEMBL3370259) Agonist activity at human GABAAalpha3beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay ChEMBL_2184618 (CHEMBL5096700) Agonist activity at STING in mouse 293T Cells incubated for 48 hrs by QUANTI-blue assay ChEMBL_64035 (CHEMBL882500) Binding affinity against endothelin receptor in rat cerebellar membrane (ET-B) from adult blue laurie rat ChEMBL_1904131 (CHEMBL4406353) Antagonist activity at human TLR7 expressed in HEK-Blue cells assessed as inhibition of CL264-induced NFkappaB activation by measuring reduction in SEAP level after overnight incubation using qunati-blue reagent by SEAP reporter gene-based spectrophotometric method ChEMBL_1989194 (CHEMBL4622741) Antagonist activity at human TLR7 overexpressed in HEK-Blue cells assessed as inhibition of gardiquimod-induced NFkappaB and AP-1 activation preincubated for 30 mins followed by gardiquimod stimulation measured after 22 hrs by quanti-blue SEAP assay ChEMBL_1989195 (CHEMBL4622742) Antagonist activity at human TLR9 overexpressed in HEK-Blue cells assessed as inhibition of ODN2006-induced NFkappaB and AP-1 activation preincubated for 30 mins followed by ODN2006 stimulation measured after 22 hrs by quanti-blue SEAP assay ChEMBL_1989198 (CHEMBL4622745) Antagonist activity at human TLR8 overexpressed in HEK-Blue cells assessed as inhibition of R848-induced NFkappaB and AP-1 activation preincubated for 30 mins followed by R848 stimulation measured after 22 hrs by quanti-blue SEAP assay ChEMBL_2340734 Agonist activity at human STING in STING knockout human THP1-Blue ISG cells expressing IRF inducible SEAP reporter construct assessed as increase in interferon production by measuring SEAP activity incubated for 24 hrs by Fingerprinting based QUANTI-Blue colorimetric assay ChEMBL_1451267 (CHEMBL3362770) Antagonist activity at mouse alpha4beta2 nAChR transfected in HEK293 cells by FLIPR membrane potential blue (FMP) assay ChEMBL_1451268 (CHEMBL3362771) Antagonist activity at rat alpha3beta4 nAChR transfected in HEK293 cells by FLIPR membrane potential blue (FMP) assay ChEMBL_1772654 (CHEMBL4229646) Inhibition of activation of recombinant human pro-heparanase expressed in CHO cells by dimethylmethylene blue based assay ChEMBL_2293974 Antagonist activity at NOD2 in human HEK-Blue hNOD2 cells assessed as inhibition of MDP-induced NOD2 activation ChEMBL_64030 (CHEMBL671549) Binding affinity against Endothelin B receptor in rat cerebellar membrane (ET-B) from adult blue laurie rat ChEMBL_64032 (CHEMBL671551) Binding affinity against Endothelin B receptor in rat cerebellar membrane (ET-B) from adult blue laurie rat ChEMBL_925780 (CHEMBL3069073) Inhibition of Arabidopsis thaliana IspF expressed in Escherichia coli XL1-Blue after 30 min by spectrophotometric analysis ChEMBL_1827123 (CHEMBL4326997) Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stimulation and measured after 24 hrs by quanti-blue staining based alkaline phosphatase reporter gene assay ChEMBL_1989196 (CHEMBL4622743) Antagonist activity at human TLR3 overexpressed in HEK-Blue cells assessed as inhibition of Poly IC-induced NFkappaB and AP-1 activation preincubated for 30 mins followed by Poly IC stimulation measured after 22 hrs by quanti-blue SEAP assay ChEMBL_1989197 (CHEMBL4622744) Antagonist activity at human TLR4 overexpressed in HEK-Blue cells assessed as inhibition of LPD-RK induced NFkappaB and AP-1 activation preincubated for 30 mins followed by LPD-RK stimulation measured after 22 hrs by quanti-blue SEAP assay ChEMBL_1855395 (CHEMBL4356124) Inhibition of C-terminal His6-tagged human IDO2 (14 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in conversion of L-tryptophan to N-formyl kynurenine using L-tryptophan as substrate after 30 mins by methylene blue dye based microplate reader analysis ChEMBL_1857751 (CHEMBL4358480) Inhibition of recombinant 6His/FLAG/Avi-tagged/Tev-fused IDO1 holoenzyme (unknown origin) expressed in Escherichia coli BL21 (DE3) using D-TRP as substrate preincubated for 15 mins at 37 degC followed by substrate addition and measured up to 10 mins by methylene blue dye based assay ChEMBL_1857752 (CHEMBL4358481) Inhibition of recombinant 6His/FLAG/Avi-tagged/Tev-fused IDO1 holoenzyme (unknown origin) expressed in Escherichia coli BL21 (DE3) using D-TRP as substrate preincubated for 15 mins at 25 degC followed by substrate addition and measured up to 10 mins by methylene blue dye based assay ChEMBL_1989201 (CHEMBL4622748) Agonist activity at human TLR9 overexpressed in HEK-Blue cells assessed as NFkappaB expression by reporter gene assay ChEMBL_2052532 (CHEMBL4707533) Inhibition of Bacillus cereus PC-phospholipase C using phosphoryl-choline as substrate by molybdenum blue dye based assay ChEMBL_2184607 (CHEMBL5096689) Agonist activity at STING (unknown origin) in THP1-Blue ISG cells assessed as type I interferon production level ChEMBL_2184617 (CHEMBL5096699) Agonist activity at STING in human 293T hSTING-R232 Cells incubated for 48 hrs by QUANTI-blue assay ChEMBL_2213471 (CHEMBL5126420) Agonist activity at human human NOD2 expressed in HEK-Blue NOD2 reporter cells by colorimetry based SEAP assay ChEMBL_2340729 Agonist activity at human wild type STING overexpressed in STING knockout human THP1-Blue ISG cells expressing IRF inducible SEAP reporter construct assessed as increase in interferon production by measuring SEAP activity incubated for 24 hrs by Fingerprinting based QUANTI-Blue colorimetric assay ChEMBL_1503943 (CHEMBL3590772) Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay ChEMBL_1503944 (CHEMBL3590773) Inhibition of human Nav1.2 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assay ChEMBL_1503945 (CHEMBL3590774) Inhibition of human Nav1.3 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assay ChEMBL_1503946 (CHEMBL3590775) Inhibition of human Nav1.7 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assay ChEMBL_2155723 (CHEMBL5040383) Inhibition of human TLR7 expressed in HEK-Blue hTLR7 cells assessed as inhibition of TLR7 by cell based assay ChEMBL_2155724 (CHEMBL5040384) Inhibition of human TLR8 expressed in HEK-Blue hTLR8 cells assessed as inhibition of TLR8 by cell based assay ChEMBL_2155725 (CHEMBL5040385) Inhibition of human TLR9 expressed in HEK-Blue hTLR9 cells assessed as inhibition of TLR9 by cell based assay ChEMBL_626546 (CHEMBL1108919) Inhibition of human TLR2 expressed in HEK-Blue-4 cells assessed as induction of NF-kappaB by SEAP assay ChEMBL_1656620 (CHEMBL4006090) Inhibition of DOT1L in human KOPN8 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay ChEMBL_1772720 (CHEMBL4229712) Inhibition of human factor B-induced cleavage of C3 after 3 hrs by coomassie brilliant blue staining-based gel electrophoresis ChEMBL_2192854 (CHEMBL5105214) Binding affinity to human CA-II assessed as inhibition constant preincubated for 15 mins by bromothymol blue staining based assay ChEMBL_2192857 (CHEMBL5105217) Binding affinity to human CA-I assessed as inhibition constant preincubated for 15 mins by bromothymol blue staining based assay ChEMBL_2262300 (CHEMBL5217311) Inhibition of Collagen-II-alpha 1 (unknown origin) incubated for 22 hrs by Coomassie blue staining based SDS-PAGE analysis ChEMBL_2268159 Inhibition of IL-4 (unknown origin) in human THP-1 cells assessed as inhibition of STAT6 phosphorylation by HEK-Blue assay ChEMBL_2354137 Agonist activity at STING in PMA-differentiated human THP1-Dual KO-STING cells incubated for 24 hrs by QUANTI-Blue assay ChEMBL_607329 (CHEMBL1064845) Inhibition of integrin alphaVbeta5 receptor-mediated adhesion of human A2780 cells to vitronectin after 1 hr by toluidine blue staining ChEMBL_607330 (CHEMBL1064846) Inhibition of integrin alphaVbeta5 receptor-mediated adhesion of human A498 cells to vitronectin after 1 hr by toluidine blue staining ChEMBL_607331 (CHEMBL1064847) Inhibition of integrin alphaVbeta3 receptor-mediated adhesion of human A498 cells to vitronectin after 1 hr by toluidine blue staining ChEMBL_607332 (CHEMBL1064848) Inhibition of integrin alphaV receptor-mediated adhesion of human PC3 cells to vitronectin after 1 hr by toluidine blue staining ChEMBL_791180 (CHEMBL1929630) Inhibition of TPR-fused MET-mediated mouse BA/F3 cell proliferation after 48 hrs by cell titre blue based spectrophotometry HEK-Blue TLR7 reporter assay Engineered human embryonic kidney blue cells (HEK-Blue TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) reporter transgene were suspended in a non-selective, culture medium (DMEM high-glucose (Invitrogen), supplemented with 10% fetal bovine serum (Sigma)). HEK-Blue TLR7 cells were added to each well of a 384-well tissue-culture plate (15,000 cells per well) and incubated 16-18 h at 37° C., 5% CO2. Compounds (100 nl) were dispensed into wells containing the HEK-Blue TLR cells and the treated cells were incubated at 37° C., 5% CO2. After 18 h treatment ten microliters of freshly-prepared Quanti-Blue reagent (Invivogen) was added to each well, incubated for 30 min (37° C., 5% CO2) and SEAP levels measured using an Envision plate reader (OD=620 nm). The half maximal effective concentration values (EC50; compound concentration which induced a response halfway between the assay baseline and maximum) were calculated. ChEMBL_1656618 (CHEMBL4006088) Inhibition of DOT1L in human MV4-11 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay ChEMBL_1656619 (CHEMBL4006089) Inhibition of DOT1L in human THP-1 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay ChEMBL_2099865 (CHEMBL4808261) Activation of mouse STING expressed in RAW-Lucia ISG cells incubated for 24 hrs by quanti-blue SEAP reporter gene assay ChEMBL_2118948 (CHEMBL4828014) Inhibition of human TLR7 in HEK-Blue hTLR7 cells assessed as reduction in gardiquimod-activated NF-KappaB by SEAP reporter assay ChEMBL_2118949 (CHEMBL4828015) Inhibition of human TLR8 in HEK-Blue hTLR8 cells assessed as reduction in R848-activated NF-KappaB by SEAP reporter assay ChEMBL_2118950 (CHEMBL4828016) Inhibition of human TLR9 in HEK-Blue hTLR9 cells assessed as reduction in ODN2006-activated NF-KappaB by SEAP reporter assay ChEMBL_2283980 Agonist activity at human TLR7 in HEK-Blue hTLR7 cells assessed as activation of NFkappaB by SEAP reporter gene based spectrophotometry assay ChEMBL_2283981 Agonist activity at human TLR8 in HEK-Blue hTLR8 cells assessed as activation of NFkappaB by SEAP reporter gene based spectrophotometry assay ChEMBL_2345479 Inhibition of TBK1 in human THP1-Blue ISG cells by measuring SEAP gene expression incubated for 24 hrs by reporter gene assay ChEMBL_676077 (CHEMBL1273071) Agonist activity at human TLR7 expressed in HEK-Blue-7 cells assessed as increase in NF-kappaB activation by sAP assay ChEMBL_813078 (CHEMBL2020652) Agonist activity at human TLR7 expressed in HEK-Blue cells assessed as increase in NFkappaB activation by sAP reporter gene assay ChEMBL_813080 (CHEMBL2020654) Agonist activity at human TLR8 expressed in HEK-Blue cells assessed as increase in NFkappaB activation by sAP reporter gene assay ChEMBL_873177 (CHEMBL2183408) Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assay ChEMBL_1677823 (CHEMBL4027966) Binding affinity to human galectin-1 expressed in Escherichia coli XL1 blue in presence of BSA by direct fluorescence polarization titration assay ChEMBL_1779485 (CHEMBL4236477) Inhibition of JAK2 in human TF1 cells assessed as reduction in EPO-induced cell proliferation after 2 days by alamar blue assay ChEMBL_1809531 (CHEMBL4308991) Inhibition of ATG4B (unknown origin) using GST-labelled LC3B as substrate after 24 hrs by coomassie blue staining-based SDS-PAGE analysis ChEMBL_1869396 (CHEMBL4370462) Inhibition of 20S immunoproteasome beta 2 in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining-based fluorescence assay ChEMBL_1869397 (CHEMBL4370463) Inhibition of 20S immunoproteasome beta 5 in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining-based fluorescence assay ChEMBL_1869399 (CHEMBL4370465) Inhibition of 20S immunoproteasome beta 1 in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining-based fluorescence assay ChEMBL_2310357 Agonist activity at human STING in human THP1-Blue ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assay ChEMBL_2437615 Agonist activity at human TLR7 expressed in HEK-blue TLR cells measured for 18 to 19 hrs by SEAP reporter gene based assay ChEMBL_2437616 Agonist activity at human TLR8 expressed in HEK-blue TLR cells measured for 18 to 19 hrs by SEAP reporter gene based assay ChEMBL_496048 (CHEMBL998478) Activity at human EAAT1 expressed in HEK293 cells assessed as inhibition of Glu-induced fluorescent response by FLIPR membrane potential blue assay ChEMBL_496051 (CHEMBL998481) Activity at rat EAAT1 expressed in TSA201 cells assessed as inhibition of Glu-induced fluorescent response by FLIPR membrane potential blue assay ChEMBL_880068 (CHEMBL2213417) Inhibition of CSF1R in mouse M-NFS-60 cells assessed as inhibition of cell proliferation after 72 hrs by Celltiter-Blue assay TLR9 Antagonist Assay HEK-Blue-hTLR9 cells were obtained from InvivoGen Inc. and used to determine test compound antagonism of human TLR9 (hTLR9) driven responses. HEK-Blue-hTLR9 cells are designed for studying the stimulation of human TLR9 by monitoring the activation of NF-kB. As described by the manufacturer, HEK-Blue-hTLR9 cells were obtained by co-transfection of the hTLR9 gene and an optimized secreted embryonic alkaline phosphatase (SEAP) reporter gene into HEK293 cells. The SEAP reporter gene is placed under the control of the IFN-b minimal promoter fused to five NF-kB and AP-1 binding sites. Stimulation with a TLR9 ligand activates NF-kB and AP-1 which induces the production of SEAP. Levels of SEAP can be easily determined with QUANTI-Blue a detection medium that turns purple/blue in the presence of alkaline phosphatase. ChEMBL_760992 (CHEMBL1815020) Inhibition of human thymidylate synthase using N5,N10-methylene tetrahydrofolate by chromogenic assay ChEBML_1644833 Inhibition of PHGDH in human HL60 cells assessed as reduction in cell viability in serine depleted medium after 5 days by presto blue assay ChEMBL_1469596 (CHEMBL3412691) Binding affinity to human FRalpha expressed in Chinese hamster RT16 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay ChEMBL_1523801 (CHEMBL3632252) Binding affinity to human FRalpha expressed in Chinese hamster RT16 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay ChEMBL_1523803 (CHEMBL3632254) Binding affinity to human FRbeta expressed in Chinese hamster D4 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay ChEMBL_1632267 (CHEMBL3874973) Inhibition of human erythrocyte carbonic anhydrase 1 preincubated for 15 mins prior to testing by bromothymol blue-based stopped-flow CO2 hydration assay ChEMBL_1632268 (CHEMBL3874974) Inhibition of human erythrocyte carbonic anhydrase 2 preincubated for 15 mins prior to testing by bromothymol blue-based stopped-flow CO2 hydration assay ChEMBL_1661016 (CHEMBL4010628) Inhibition of recombinant human CYP2C19 expressed in baculosomes using Vivid EOMCC substrate blue measured every 30 sec for 30 mins by fluorescence assay ChEMBL_1661019 (CHEMBL4010631) Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMCC substrate blue measured every 30 sec for 30 mins by fluorescence assay ChEMBL_1661020 (CHEMBL4010632) Inhibition of recombinant human CYP2D6 expressed in baculosomes using Vivid EOMCC substrate blue measured every 30 sec for 30 mins by fluorescence assay ChEMBL_2064386 (CHEMBL4719639) Activation of STING in human blood assessed as induction of type I IFNs incubated for 18 to 20 hrs by QUANTI-Blue assay ChEMBL_2130603 (CHEMBL4840032) Inhibition of Staphylococcus aureus topoisomerase IV decatenation activity using kDNA as substrate by ethidium bromide/bromophenol blue staining based agarose gel electrophoresis analysis ChEMBL_2223208 (CHEMBL5136542) Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity incubated for 25 min by ethidium bromide/bromophenol blue staining based agarose gel electrophoresis analysis ChEMBL_2343718 Agonist activity at human TLR2 expressed in HEK-Blue hTLR2 cells as SEAP expression incubated for 16 hrs by SEAP-based plate reader analysis ChEMBL_813079 (CHEMBL2020653) Antagonist activity at human TLR7 expressed in HEK-Blue cells assessed as inhibition of gardiquimod-induced NFkappaB activation by sAP reporter gene assay ChEMBL_813081 (CHEMBL2020655) Antagonist activity at human TLR8 expressed in HEK-Blue cells assessed as inhibition of CL075-induced NFkappaB activation by sAP reporter gene assay ChEMBL_948812 (CHEMBL2339774) Inhibition of human recombinant polyhistidine-tagged plasma kallikrein expressed in Escherichia coli XL1 blue using Z-FR-AMC as substrate by fluorimetric analysis ChEMBL_1469594 (CHEMBL3412689) Binding affinity to human RFC expressed in Chinese hamster PC43-10 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay ChEMBL_1469597 (CHEMBL3412692) Binding affinity to human PCFT expressed in Chinese hamster R2/PCFT4 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay ChEMBL_1523799 (CHEMBL3632250) Binding affinity to human RFC expressed in Chinese hamster PC43-10 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay ChEMBL_1523805 (CHEMBL3632256) Binding affinity to human PCFT expressed in Chinese hamster R2/PCFT4 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay ChEMBL_1618142 (CHEMBL3860311) Binding affinity to Staphylococcus aureus His6-biotinylated SrtA expressed in Escherichia coli XL1-blue using fluorescein-tagged compound after 15 mins by fluorescence polarization ChEMBL_1644829 (CHEMBL3993758) Inhibition of PHGDH in human SiHa cells assessed as reduction in cell viability in serine repleted medium after 5 days by presto blue assay ChEMBL_1644830 (CHEMBL3993759) Inhibition of PHGDH in human SiHa cells assessed as reduction in cell viability in serine depleted medium after 5 days by presto blue assay ChEMBL_1644832 (CHEMBL3993761) Inhibition of PHGDH in human HL60 cells assessed as reduction in cell viability in serine repleted medium after 5 days by presto blue assay ChEMBL_1644833 (CHEMBL3993762) Inhibition of PHGDH in human HL60 cells assessed as reduction in cell viability in serine depleted medium after 5 days by presto blue assay ChEMBL_1779484 (CHEMBL4236476) Inhibition of JAK1/JAK3 in human PBMC assessed as reduction in IL-2-induced T cell proliferation after 3 days by alamar blue assay ChEMBL_2187831 (CHEMBL5099913) Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as increase in NFkappaB activation incubated for 18 hrs by SEAP-based spectrophotometry analysis ChEMBL_2187832 (CHEMBL5099914) Agonist activity at TLR7 in HEK-Blue hTLR7 cells assessed as increase in NFkappaB activation incubated for 18 hrs by SEAP-based spectrophotometry analysis ChEMBL_2226074 (CHEMBL5139587) Inhibition of N-terminal thioredoxin-tagged Mycobacterium smegmatis DprE1 expressed in Escherichia coli BL21(DE3) incubated for 7 days by microplate alamar blue assay ChEMBL_2267948 Agonist activity at human TLR8 stably expressed in human HEK-Blue hTLR8 cells assessed as activation of NFkappaB by SAP reporter gene based spectrophotometric assay ChEMBL_2267955 Antagonist activity at human TLR9 expressed in HEK-Blue hTLR9 cells assessed as activation of NFkappaB incubated for 16 hrs by luciferase reporter gene assay ChEMBL_2310369 Agonist activity at human STING in STING knockout human THP1-Blue ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assay ChEMBL_2373012 Agonist activity at STING in human 293-Dual hSTING-R232 cells assessed as IRF3 activation by measuring ISRE-inducible SEAP activity by QUANTI-Blue assay ChEMBL_2373013 Agonist activity at STING in human 293-Dual hSTING-R232 cells assessed as INF-beta activation by measuring lucia luciferase activity by QUANTI-Blue assay ChEMBL_1281371 (CHEMBL3101466) Inhibition of human TS using dUMP and methylene-THF as substrate by kaleidagraph analysis ChEMBL_760996 (CHEMBL1815024) Inhibition of Enterococcus faecalis thymidylate synthase using N5,N10-methylene tetrahydrofolate by chromogenic assay ChEMBL_760998 (CHEMBL1815026) Inhibition of Lactobacillus casei thymidylate synthase using N5,N10-methylene tetrahydrofolate by chromogenic assay ChEMBL_1335312 (CHEMBL3238809) Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane potential blue assay ChEMBL_1335313 (CHEMBL3238810) Antagonist activity at rat alpha3/beta4 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane potential blue assay ChEMBL_1576582 (CHEMBL3807377) Inhibition of FATP2 in human HepG2 cells assessed as decrease in fatty acid transport after 5 mins by trypan blue dye based fluorescence quenching method ChEMBL_1763413 (CHEMBL4198660) Inhibition of Escherichia coli DNA gyrase-B using relaxed pUC19 DNA as substrate after 1 hr by bromophenol blue dye based agarose gel electrophoresis method ChEMBL_1796971 (CHEMBL4269088) Antagonist activity at human TLR9 expressed in HEK-Blue cells assessed as reduction in CpGB-induced NF-kappaB levels after 24 hrs by spectrophotometric analysis ChEMBL_1796972 (CHEMBL4269089) Antagonist activity at human TLR7 expressed in HEK-Blue cells assessed as reduction in CL264-induced NF-kappaB levels after 24 hrs by spectrophotometric analysis ChEMBL_1855694 (CHEMBL4356423) Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP assay ChEMBL_1855695 (CHEMBL4356424) Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP assay ChEMBL_1855720 (CHEMBL4356449) Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in ssRNA-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP assay ChEMBL_1990473 (CHEMBL4624208) Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay ChEMBL_1990484 (CHEMBL4624219) Inhibition of DHFR in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay ChEMBL_2130602 (CHEMBL4840031) Inhibition of Staphylococcus aureus Gyrase supercoiling activity assessed as reduction in supercoiling pBR322 DNA by measuring relaxation by bromophenol blue staining based TAE gel method ChEMBL_2155335 (CHEMBL5039995) Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as increase in NFkappaB transactivation-mediated SEAP activity measured after 18 hrs by spectrophotometric method ChEMBL_2160779 (CHEMBL5045529) Agonist activity at STING in human THP1 Dual cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assay ChEMBL_2283983 Agonist activity at human TLR8 (27 to 287 residues) in HEK-Blue hTLR8 cells assessed as induction of NFkappaB by SEAP reporter gene based spectrophotometry assay ChEMBL_876141 (CHEMBL2183535) Positive ago-allosteric modulation of GLP2R overexpressed in human SE302 cells assessed as placental alkaline phosphatase activation measured on day 3 by Alamar Blue assay TLR7 Agonist Activity Assay Engineered human embryonic kidney blue cells (HEK-Blue TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) reporter transgene were suspended in a non-selective, culture medium (DMEM high-glucose (Invitrogen), supplemented with 10% fetal bovine serum (Sigma)). HEK-Blue TLR7 cells were added to each well of a 384-well tissue-culture plate (15,000 cells per well) and incubated 16-18 h at 37° C., 5% CO2. Compounds (100 nl) were dispensed into wells containing the HEK-Blue TLR cells and the treated cells were incubated at 37° C., 5% CO2. After 18 h treatment ten microliters of freshly-prepared Quanti-Blue reagent (Invivogen) was added to each well, incubated for 30 min (37° C., 5% CO2) and SEAP levels measured using an Envision plate reader (OD=620 nm). The half maximal effective concentration values (EC50; compound concentration which induced a response halfway between the assay baseline and maximum) were calculated. ChEMBL_1618140 (CHEMBL3860309) Inhibition of Staphylococcus aureus His6-biotinylated SrtA expressed in Escherichia coli XL1-blue using Dabcyl-LPETG-Edans as substrate assessed as residual activity by fluorescence assay ChEMBL_1674488 (CHEMBL4024517) Agonist activity at human NOD2 expressed in HEK-Blue cells assessed as induction of NF-kB transcriptional activity after 18 hrs by SEAP reporter gene assay ChEMBL_1685227 (CHEMBL4035706) Inhibition of carbonic anhydrase-1 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by bromine thymol blue indicator based assay ChEMBL_1685228 (CHEMBL4035707) Inhibition of carbonic anhydrase-2 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by bromine thymol blue indicator based assay ChEMBL_1869383 (CHEMBL4370449) Inhibition of 20S constitutive proteasome beta 5 chymotrypsin-like activity in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining-based fluorescence assay ChEMBL_1869395 (CHEMBL4370461) Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining-based fluorescence assay ChEMBL_1869398 (CHEMBL4370464) Inhibition of 20S constitutive proteasome beta 1 caspase-like activity in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining-based fluorescence assay ChEMBL_1901006 (CHEMBL4403228) Agonist activity at human TLR2 expressed in HEK-Blue cells co-expressing NF-kappaB-SEAP reporter gene measured after 16 hrs by SEAP reporter gene assay ChEMBL_1922292 (CHEMBL4425248) Inhibition of BCR-ABL (unknown origin) expressed in mouse BA/F3 cells assessed as decrease in cell viability after 48 hrs by trypan blue exclusion assay ChEMBL_2059595 (CHEMBL4714596) Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-blue assay ChEMBL_2059597 (CHEMBL4714598) Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-blue assay ChEMBL_2059598 (CHEMBL4714599) Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-blue assay ChEMBL_2059599 (CHEMBL4714600) Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-blue assay ChEMBL_2160780 (CHEMBL5045530) Agonist activity at STING in mouse RAW-Lucia ISG cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assay ChEMBL_2160783 (CHEMBL5045533) Agonist activity at STING in human THP1-Dual cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assay ChEMBL_2475979 Binding affinity to sialyl LewisX mimetic 21a pretreated Blue-NHS-labelled E-selectin Lec-EGF/SCR1/SCR2 domain (unknown origin) measured after 20 mins by microscale thermophoresis ChEBML_257 Compound was tested for in vitro inhibition of 5,10-Methylene Tetrahydrofolate Cyclohydrolase, competitive against (+)-L-5,10-methenyltetrahydrofolate ChEMBL_2379020 Antagonist activity at human P2X3 receptor transfected in CHO cells assessed as inhibition of alpha,beta-methylene ATP induced intracellular calcium level preincubated for 10 mins followed by alpha,beta-methylene ATP addition and measured immediately by bioluminescence based analysis ChEBML_1681666 Agonist activity at human TLR4 expressed in HEK293 blue cells assessed as induction of NF-kappaB activation-mediated SEAP production after 20 to 24 hrs by colorimetric assay ChEBML_1681667 Agonist activity at mouse TLR4 expressed in HEK293 blue cells assessed as induction of NF-kappaB activation-mediated SEAP production after 20 to 24 hrs by colorimetric assay ChEMBL_1431345 (CHEMBL3387471) Inhibition of FRalpha (unknown origin) expressed in Chinese hamster RT16 cells assessed as cell growth inhibition incubated up to 96 hrs by Celltiter-blue cell viability assay ChEMBL_1431347 (CHEMBL3387473) Inhibition of FRbeta (unknown origin) expressed in Chinese hamster D4 cells assessed as cell growth inhibition incubated up to 96 hrs by Celltiter-blue cell viability assay ChEMBL_2059917 (CHEMBL4714918) Inhibition of IL-6 induced STAT3 transcriptional activity in human HEK-Blue IL-6 cells assessed as secreted embryonic alkaline phosphatase reporter gene expression by microplate reader ChEMBL_2160781 (CHEMBL5045531) Agonist activity at STING in human THP1 Dual KO-STING cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assay ChEMBL_2322374 Activation of STING signalling pathway in human THP1-Dual cells assessed as increase in NF-kappaB-SEAP activation incubated for 24 hrs by QUANTI-Blue reagent based assay Competitive Binding Assay A synthetic 14-mer peptide, TN14003, was previously reported to block both SDF-1/CXCR4 mediated invasion in vitro and metastasis in vivo with a high specificity by binding competitively with its ligand SDF-1. Aa competitive binding assay using biotin-labeled TN14003 and streptavidin-conjugated rhodamine was developed to determine the binding efficiency of new chemical entities to the SDF-1 binding domain of CXCR4. Cells incubated with high affinity compounds show only blue nuclear staining, whereas compounds with low affinity result in staining CXCR4 (red; rhodamine) as well as the nuclei (blue; cytox blue).
METHYLENE BLUE CHLORIDE HYDRATE BDBM50434369 Methylthioninium Chloride Methylthionine Chloride Methylene Blue Methylthionine HCl
cid_6099 Basic Blue 9 Methylenblau SAMPL5, CBC-G10 BDBM50241461 bleu de methylene Methylene blue Methylene blue (10) methylthioninium chloride 3,7-bis(dimethylamino)phenothiazin-5-ium chloride azul de metileno CHEMBL405110 Methylene Blue anhydrous
BDBM50458539 Chicago Sky Blue CHICAGO SKY BLUE SODIUM Chicago Sky Blue 6B
Azovan Blue EVANS BLUE Azovan sodium BDBM50366944
BDBM50300129 Cibacron Blue 3Ga CIBACRON BLUE CHEMBL572528
Bromphenol blue BDBM85045
TRYPAN BLUE BDBM50366943
Bromphenol blue BDBM85044 CAS_8272 CAS_115-39-9 Brophenol Blue NSC_8272
BDBM50118235 Brilliant Blue CHEMBL423337
BDBM50118231 Cibachron Blue 3GA CHEMBL134193
Reactive Blue 2 BDBM50179359 CHEBI:34946
Saxon blue BDBM50651694 NSC-8646 Blue x Indigotindisulfonic acid 5,5''-indigotindisulfonic acid Indigotindisulfonate Indigo carmine acid
BDBM103568 ATX inhibitor 16 Chicago Sky Blue
TOLONIUM CHLORIDE BDBM50430742 Toluidine Blue O Blutene
BDBM50191686 CHEMBL213124 methylene-bis-methylphlorobutyrophenone
CHEMBL1164991 BDBM50320829 (oxalylamino-methylene)-thiophenesulfonamide
CHEMBL2171768 BDBM50016248 5-(Methylene)Evodiamine
uridine5'-methylene-phosphonate CHEMBL522015 BDBM50258427
BDBM81348 beta-Lapachone Beta lapachone R115 (Reactive Blue 2) β-Lapachone (A3)
BDBM233117 α-Methylene-γ-lactone, 3
BDBM233118 α-Methylene-γ-lactone, 1
BDBM50007907 CHEMBL3350647 alpha,beta-methylene AzddTPP
CHEMBL2312925 3,3''-((Diphenylphosphoryl)Methylene)Dipyridine BDBM50425112
CHEMBL3350644 BDBM50007910 beta,gama-methylene AzddTPP
(cibacron blue,meta isomer)1-Amino-4-{4-[4-chloro-6-(3-sulfo-phenylamino)-[1,3,5]triazin-2-ylamino]-3-sulfo-phenylamino}-9,10-dioxo-9,10-dihydro-anthracene-2-sulfonic acid basilen blue BDBM50029037
BDBM50288854 5-Methylene-piperidine-3,4-diol CHEMBL150938
CHEMBL310688 BDBM50128610 2-(4-Methoxy-benzenesulfonyl)-4-methylene-2-(2-methylene-but-3-enyl)-hex-5-enoic acid hydroxyamide
1-((3-bromophenyl)(phenyl)methylene)thiosemicarbazide BDBM50189280 CHEMBL376207
BDBM50108508 CHEMBL87967 3-Methylene-dihydro-furan-2,5-dione
BDBM50339261 3-((phenylamino)methylene)indolin-2-one CHEMBL1689601
CHEMBL384296 BDBM50189279 1-(bis(3-bromophenyl)methylene)thiosemicarbazide
BDBM50227032 acid blue 25 CHEMBL256057 sodium 1-amino-9,10-dioxo-4-(phenylamino)-9,10-dihydroanthracene-2-sulfonate
1,1'-(naphthalene-2,7-diylbis(methylene))diquinolinium dibromide BDBM50339942 CHEMBL1762003
2-[(Amino-methoxy-methylene)-sulfamoyl]-benzoic acid BDBM50087934 CHEMBL53303
4,4''-(1,2-Phenylenebis(Methylene))Bis(Oxy)Dibenzimidamide CHEMBL181480 BDBM50189311
4-Amino-N-(amino-methoxy-methylene)-benzenesulfonamide BDBM50087991 CHEMBL51181
BDBM223127 2-((5-phenylfuran-2-yl)methylene)hydrazinecarboxamide (4a)
BDBM283725 US10023559, Example 50 3-[(4-bromophenyl)methylene]azetidine
BDBM50087899 CHEMBL53521 N-(Amino-methoxy-methylene)-4-bromo-benzenesulfonamide
BDBM50087977 CHEMBL298638 N-(Amino-methoxy-methylene)-4-iodo-benzenesulfonamide
BDBM50087997 CHEMBL51497 N-(Amino-methoxy-methylene)-3-nitro-benzenesulfonamide
BDBM50153474 4-Methylene-6-octylamino-cyclohexane-1,2,3-triol CHEMBL368030
BDBM50316628 N-((4-methoxyphenyl)(phenyl)methylene)-4-methylaniline CHEMBL1098663
BDBM50477849 2,3-Dihydroxybenzoic Acid [(2,3-Dihydroxyphenyl)Methylene]Hydrazide CHEMBL399581
BDBM86101 2-[Cyano(3-indolyl) methylene]-3-indolone, 1
CHEMBL254646 BDBM50477846 2,3-Dihydroxybenzoic Acid [(2,3-Dimethoxyphenyl)Methylene]Hydrazide
CHEMBL299792 N-(Amino-methoxy-methylene)-4-methoxy-benzenesulfonamide BDBM50087995
CHEMBL3144396 BDBM50019476 alpha-methylene-Thiazole-4-carboxamide adenine dinucleotide
CHEMBL365916 4,4''-(1,4-Phenylenebis(Methylene))Bis(Oxy)Dibenzimidamide BDBM50189310
CHEMBL416115 BDBM50087913 N-(Amino-methoxy-methylene)-4-methyl-benzenesulfonamide
CHEMBL51177 BDBM50087966 3-Amino-N-(amino-methoxy-methylene)-benzenesulfonamide
CHEMBL52275 BDBM50087933 4-[(Amino-methoxy-methylene)-sulfamoyl]-benzoic acid
CHEMBL54137 BDBM50087922 N-(Amino-methoxy-methylene)-2,4,6-trimethyl-benzenesulfonamide
CHEMBL54196 BDBM50087990 3-[(Amino-methoxy-methylene)-sulfamoyl]-benzoic acid
CHEMBL602454 2-(bis(3-bromophenyl)methylene)-N-ethylhydrazinecarbothioamide BDBM50306673
CHEMBL85122 4-(2-Diethylamino-1-methylene-propyl)-phenol BDBM50129603
N-(Amino-methoxy-methylene)-2,3,4,5,6-pentafluoro-benzenesulfonamide BDBM50087928 CHEMBL53304
N-(Amino-methoxy-methylene)-2-nitro-benzenesulfonamide BDBM50087984 CHEMBL51446
N-(Amino-methoxy-methylene)-4-chloro-benzenesulfonamide BDBM50087958 CHEMBL51997
N-(Amino-methoxy-methylene)-4-fluoro-benzenesulfonamide BDBM50087972 CHEMBL53533
N-(Amino-methoxy-methylene)-4-nitro-benzenesulfonamide CHEMBL52161 BDBM50087970
N-(Amino-methoxy-methylene)-C-phenyl-methanesulfonamide BDBM50087919 CHEMBL50103
gama-methylene-Thiazole-4-carboxamide adenine dinucleotide CHEMBL3144394 BDBM50019477
Acid Blue 129 BDBM50118211 CHEMBL133576 cid_23675739 sodium 1-amino-4-(mesitylamino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate
(3Z)-3-[(1-adamantylamino)methylene]pyrrolidine-2,4-quinone (3Z)-3-[(1-adamantylamino)methylidene]pyrrolidine-2,4-dione SMR000024594 MLS000089976 (3Z)-3-[(1-adamantylamino)methylene]pyrrolidine-2,4-dione BDBM87400 cid_1736194 (3E)-3-[(1-adamantylamino)methylene]pyrrolidine-2,4-quinone
(2R,3S)-4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (trans)-4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid BDBM50256128 CHEMBL449993
CHEMBL221271 N'-nitro-2-{[5-(3-nitrophenyl)-2-furyl]methylene}hydrazinecarboximidamide BDBM50195456 N'-nitro-2-((5-(3-nitrophenyl)furan-2-yl)methylene)hydrazinecarboximidamide
Bis[4-Amino-5-hydroxy-6-(2-methoxy-phenylazo)-naphthalene-1,3-disulfonic acid](Chicago Sky Blue) BDBM50113317 CHEMBL311909
1,1'-[Biphenyl-3,3'-diylbis(methylene)]bis(quinuclidinium)bromide CHEMBL1771549 BDBM50342852
1-(4-Cyanobenzyl)-5-(methylene-acetate)-1H-imidazole CHEMBL599222 BDBM50307236
1alpha,25-Dihydroxy-2-methylene-18,19,21-trinorvitamin D3 CHEMBL594078 BDBM50304583
2-Methylene-dodecanoic acid (2,4,6-trimethoxy-phenyl)-amide CHEMBL44099 BDBM50005940
3,3'-(piperazine-1,4-diylbis(methylene))dibiphenyl-4-ol CHEMBL1163649 BDBM50320670
BDBM50087943 CHEMBL54307 N-{4-[(Amino-methoxy-methylene)-sulfamoyl]-phenyl}-acetamide
BDBM50270284 (E/Z)-3-[(Naphty-2'-yl-)-methylene]-quinuclidine CHEMBL517057
BDBM50330032 CHEMBL1272262 2-((3-(benzyloxy)phenyl)(3-bromophenyl)methylene)hydrazinecarbothioamide
CHEMBL600178 BDBM50306672 N-benzyl-2-(bis(3-bromophenyl)methylene)hydrazinecarbothioamide
CHEMBL607373 1alpha,25-Dihydroxy-2-methylene-19,21-dinorvitamin D3 BDBM50304584
N,N'-[4,5-Acridindiylbis(methylene)]bis(2-dimethylaminoacetamide) BDBM50298381 CHEMBL573386
N,N'-[4,5-Acridindiylbis(methylene)]bis(3-dimethylaminopropanamide) BDBM50298383 CHEMBL575850
(E)-N'-[(2- hydroxynaphthalen-1- yl)methylene]-2-{N-{2-[N- (naphthalen-1-yl- methylene)-N- methylamino]ethyl}N- methylamino}acethydrazide US10196346, Example 4 BDBM332030
(20S)-1alpha,25-Dihydroxy-2-methylene-18,19-dinorvitamin D3 BDBM50304585 CHEMBL596532
1,1'-(1,3-phenylenebis(methylene))bis(3-(4-methoxyphenethyl)urea) CHEMBL475956 BDBM50266738
1,1'-[1,3-Phenylenebis(methylene)]bis[4-(dimethylamino)pyridinium]bromide BDBM50342856 CHEMBL1771366
1,1'-[1,4-Phenylenebis(methylene)]bis[4-(dimethylamino)pyridinium]bromide BDBM50342859 CHEMBL1771369
1,1'-[Biphenyl-3,3'-diylbis(methylene)]bis(3-hydroxyquinuclidinium)bromide CHEMBL1771550 BDBM50342883
1,1'-[Biphenyl-3,3'-diylbis(methylene)]bis(4-phenylpyridinium)bromide BDBM50342863 CHEMBL1771534
2-((3-bromo-2-hydroxyphenyl)(3-bromophenyl)methylene)hydrazinecarbothioamide CHEMBL1271546 BDBM50330038
2-((3-bromophenyl)(2-bromopyridin-3-yl)methylene)hydrazinecarbothioamide BDBM50330047 CHEMBL1269733
2-((3-bromophenyl)(6-bromopyridin-3-yl)methylene)hydrazinecarbothioamide CHEMBL1269732 BDBM50330046
2-((5-(3-fluorophenyl)furan-2-yl)methylene)hydrazinecarboxamide (4d) BDBM223128
2-((5-(4-aminophenyl)furan-2-yl)methylene)hydrazinecarboxamide (4j) BDBM223132
2-((5-(4-methoxyphenyl)furan-2-yl)methylene)hydrazinecarboxamide (4h) BDBM223131
2-((5-(4-nitrophenyl)furan-2-yl)methylene)hydrazinecarboxamide (4g) BDBM223130
2-((6-(4-chlorophenyl)pyridin-2-yl)methylene)hydrazinecarboxamide (9g) BDBM223136
2-Thiouridine-5'-alpha,beta-methylene Diphosphate,bis-Triethylammonium Salt BDBM50303338
2-[(Benzofuroxan-5-yl)methylene]-1-(2-hydroxybenzylidene)hydrazine BDBM50243052 CHEMBL444202
3-((3-bromothiophen-2-yl)methylene)indolin-2-one BDBM50205549 CHEMBL230414
3-((5-nitrofuran-2-yl)methylene)pentane-2,4-dione BDBM50336264 CHEMBL1669734
5-[Bis-(4-chloro-phenyl)-methylene]-1,4,5,6-tetrahydro-pyrimidine BDBM50024489 CHEMBL29905
BDBM223129 2-((5-(4-fluorophenyl)furan-2-yl)methylene)hydrazinecarboxamide (4e)
BDBM223135 2-((5-(4-chlorophenyl)pyridin-3-yl)methylene)hydrazinecarboxamide (9f)
BDBM50028713 8-Imidazol-1-yl-2-methylene-octanoic acid; hydrochloride CHEMBL537260
BDBM50087900 2-[(Amino-methoxy-methylene)-sulfamoyl]-3,4,5,6-tetrabromo-benzoic acid CHEMBL50449
BDBM50087931 CHEMBL299607 N-(Amino-methoxy-methylene)-3-chloro-4-nitro-benzenesulfonamide
BDBM50162816 Methylene diphsphonate Phosphonomethyl-phosphonic acid Medronic acid CHEMBL180570 methylenediphosphonic acid
BDBM50243053 2-[(Benzofuroxan-5-yl)methylene]-1-(4-hydroxybenzylidene)hydrazine CHEMBL504491
BDBM50267769 4-[(3,4-Dihydroxy-phenylamino)-methylene]-4H-isoquinoline-1,3-dione CHEMBL489424
BDBM50273851 2-[(3-chloro-1H-inden-2-yl)methylene]hydrazinecarboximidamide CHEMBL456598
BDBM50326007 4,4'-(naphthalen-2-ylazanediyl)bis(methylene)dibenzene-1,2-diol CHEMBL1241670
CHEMBL1240658 N'-((4-oxo-4H-chromen-3-yl)methylene)butyrohydrazide BDBM50326125
CHEMBL1241822 BDBM50326128 N'-((4-oxo-4H-chromen-3-yl)methylene)benzohydrazide
CHEMBL1289106 BDBM50331896 E-3-[[4-(Methylsulfonyl)phenyl]methylene]-indolin-2-one
CHEMBL1290660 BDBM50331889 E-3-[[4-(Sulfamoyl)phenyl]methylene]-indolin-2-one
CHEMBL1689599 (Z/E)-3-((dimethylamino)methylene)-1-methylindolin-2-one BDBM50339259
CHEMBL1771533 1,1'-[Biphenyl-3,3'-diylbis(methylene)]bis(4-cyclohexylpyridinium)bromide BDBM50342862
CHEMBL297032 BDBM50087938 N-(Amino-methoxy-methylene)-3,5-dichloro-2-hydroxy-benzenesulfonamide
CHEMBL431538 BDBM50087909 N-(Amino-methoxy-methylene)-4-(4-dimethylamino-phenylazo)-benzenesulfonamide
CHEMBL450383 BDBM50267770 4-[(3,4-Dihydroxy-benzylamino)-methylene]-4H-isoquinoline-1,3-dione
CHEMBL50155 3-Amino-N-(amino-methoxy-methylene)-4-methoxy-benzenesulfonamide BDBM50087884
N-(Amino-methoxy-methylene)-C,C,C-trifluoro-methanesulfonamide BDBM50087981 CHEMBL52323
(3E)-3-[(1-adamantylamino)methylidene]pyrrolidine-2,4-dione SMR000137098 BDBM87420 3-[(1-adamantylamino)methylene]-2,4-pyrrolidinedione MLS000532157 cid_741223 (3E)-3-[(1-adamantylamino)methylene]pyrrolidine-2,4-quinone
(Lactone1)N-[4-(6-Methylene-2-oxo-tetrahydro-pyran-3-yl)-benzyl]-guanidine CHEMBL335908 BDBM50003742 N-[4-(6-Methylene-2-oxo-tetrahydro-pyran-3-yl)-benzyl]-guanidine
5-((5-(2,5-dichlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one CHEMBL390528 (Z)-5-((5-(2,5-dichlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one BDBM50211897
BDBM50211912 5-((5-(2-chlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one (Z)-5-((5-(2-chlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one CHEMBL226813
US11787766, Compound 18 N,N-((((((pyridine-2,6-diyl-bis (methylene)) bis (oxo)) bis (2-methoxypyridine-6,3-diyl)) bis (methylene)) bis (azetanediyl)) bis (ethane-2,1-diyl)) diacetamide BDBM626252
(1Z,N'E)-N'-((3,5-diaminopyridin-2-yl)methylene)carbamohydrazonothioic acid BDBM50051771 CHEMBL86910
(E)-2-(2-((1H-indol-3-yl)methylene)hydrazinyl)quinoxaline (27) BDBM193774
(Z/E)-5-chloro-3-((dimethylamino)methylene)indolin-2-one CHEMBL1689596 BDBM50339256
(Z/E)-6-chloro-3-((dimethylamino)methylene)indolin-2-one CHEMBL1689597 BDBM50339257
1,1'-(4,6-dimethyl-1,3-phenylene)bis(methylene)diindoline-2,3-dione BDBM50342559 CHEMBL1770391
3-((1H-pyrrol-2-yl)methylene)-4-methylindolin-2-one CHEMBL396788 BDBM50205556
3-Hexadecanoyl-4-hydroxy-5-methylene-5H-furan-2-one CHEMBL110642 BDBM50104677
BDBM108084 3-((5-nitrothiophen-2-yl)methylene)indolin-2-one (Compound 25)
BDBM50031474 CHEMBL307364 (2E)-2-[(5-hydroxy-1H-indol-3-yl)methylene]hydrazinecarboximidamide
BDBM50152561 CHEMBL181811 2-Methylene-4-oxo-4-(4-phenoxy-phenyl)-butyric acid
BDBM50298377 CHEMBL576188 N,N'-[4,5-Acridindiylbis(methylene)]bis[4-(1-piperidinyl)butanamide]
BDBM50298378 N,N'-[4,5-Acridindiylbis(methylene)]bis[4-(1-pyrrolidinyl)-butanamide] CHEMBL573120
BDBM50340958 CHEMBL1762243 2-amino-N-(amino(4-methylquinazolin-2-ylamino)methylene)benzamide
CHEMBL1241669 4,4'-(1H-indazol-6-ylazanediyl)bis(methylene)dibenzene-1,2-diol BDBM50326005
CHEMBL1257683 BDBM50328397 (E)-3-((3-methylazulen-1-yl)methylene)indolin-2-one
CHEMBL1257803 (Z)-3-((3-methylazulen-1-yl)methylene)indolin-2-one BDBM50328398
CHEMBL1689598 (Z/E)-7-chloro-3-((dimethylamino)methylene)indolin-2-one BDBM50339258
CHEMBL1770392 BDBM50342574 1,1'-(2,5-dimethyl-1,4-phenylene)bis(methylene)diindoline-2,3-dione
CHEMBL198840 BDBM50178748 N'-[(4-{[(3,5-dihydroxybenzoyl)hydrazono]methyl}phenyl)methylene]-3,5-dihydroxybenzohydrazide
CHEMBL573387 N,N'-[4,5-Acridindiylbis(methylene)]bis[3-(1-piperidinyl)propanamide] BDBM50298384
CHEMBL577150 N,N'-[4,5-Acridindiylbis(methylene)]bis[3-(1-pyrrolidinyl)propanamide] BDBM50298374
CHEMBL597366 3-((4-(dimethylamino)naphthalen-1-yl)methylene)indolin-2-one BDBM50307123
N,N'-[4,5-Acridindiylbis(methylene)]bis[2-(1-pyrrolidinyl)acetamide] BDBM50298382 CHEMBL573353
3,3′-(((((((2,2′-dimethyl[1,1′-biphenyl]-3,3′-diyl) bis (methylene)) bis (oxo)) bis (2-methoxypyridine-6,3-diyl)) bis (methylene)) bis (azetanediyl)) dipropionamide US11787766, Compound 22 BDBM626255
9-fluoro-2,2,4-trimethyl-5-methylene-2,5-dihydro-1H-chromeno[3,4-f]quinoline 9-Fluoro-2,2,4-trimethyl-5-methylene-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL64913 BDBM50129150
CHEMBL1779064 BDBM50344635 N-((5-(4-chloro-3-nitrophenyl)furan-2-yl)methylene)-3-(2-((5-(4-chloro-3-nitrophenyl)furan-2-yl)methylene)hydrazinyl)-4H-1,2,4-triazol-4-amine
N'-[(2-hydroxy-1-naphthyl)methylene]-3-(2-naphthyl)-1H-pyrazole-5-carbohydrazide CHEMBL1241832 BDBM50331854 N'-((2-hydroxynaphthalen-1-yl)methylene)-3-(naphthalen-2-yl)-1H-pyrazole-5-carbohydrazide
US11787766, Compound 19 BDBM626253 N, N′-((((((((2-methyl-1,3-phenylene) bis (methylene)) bis (oxo)) bis (2-methoxypyridine-6,3-diyl)) bis (methylene)) bis (azetanediyl)) bis (ethane-2,1-diyl)) diacetamide
amino{[4-(2-methylene-6-oxotetrahydro-2H-pyran-4-yl)phenyl]amino}methaniminium BDBM50003740 (Lactone IIa)N-[4-(2-Methylene-6-oxo-tetrahydro-pyran-4-yl)-phenyl]-guanidine CHEMBL134926
(1Z,N'E)-N'-((3-(methylamino)pyridin-2-yl)methylene)carbamohydrazonothioic acid BDBM50051768 CHEMBL87471
(1Z,N'E)-N'-((5-(allylamino)pyridin-2-yl)methylene)carbamohydrazonothioic acid BDBM50051775 CHEMBL82809
(1Z,N'E)-N'-((5-(butylamino)pyridin-2-yl)methylene)carbamohydrazonothioic acid BDBM50051766 CHEMBL420050
(1Z,N'E)-N'-((5-(ethylamino)pyridin-2-yl)methylene)carbamohydrazonothioic acid CHEMBL86188 BDBM50051776
(1Z,N'E)-N'-((5-(methylamino)pyridin-2-yl)methylene)carbamohydrazonothioic acid BDBM50051769 CHEMBL314693
(2S)-2-amino-4-methylidenepentanedioic acid BDBM50089912 4-methylene-L-glutamic acid CHEMBL38499
(2S)-2-amino-5-{[(1Z)-(hydroxyamino)(methylthio)methylene]amino}pentanoic acid BDBM50077250 CHEMBL57164
(2S)-2-amino-5-{[(1Z)-hydrazino(methylthio)methylene]amino}pentanoic acid BDBM50077251 CHEMBL53060
1,1-(Methylene-di-1,4-phenylene)-bismaleimide BDBM50270000 1,10-(methylenedi-4,1-phenylene)bismaleimide CHEMBL478304
10,13-Dimethyl-3-methylene-1,2,3,6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-17-one BDBM50014302 CHEMBL98105
2-((5-(2-amino-4-chlorophenyl)furan-2-yl)methylene)hydrazinecarboxamide (4m) BDBM223133
2-Hexyl-4-methylene-5-oxo-tetrahydro-thiophene-3-carboxylic acid BDBM50267032 CHEMBL476446
2-hydroxy-N'-[(4-{[(2-hydroxybenzoyl)hydrazono]methyl}phenyl)methylene]benzohydrazide CHEMBL222871 BDBM50157749
3-((3-phenyl-1H-pyrazol-4-yl)methylene)indolin-2-one BDBM50344214 CHEMBL1778710
3-{[(1E)-(3-Chlorophenyl)methylene]amino}-2-phenylquinazolin-4(3H)-one CHEMBL1163632 BDBM50321120
4-methyl-N'-((4-oxo-4H-chromen-3-yl)methylene)benzenesulfonohydrazide CHEMBL1241823 BDBM50326127
5-methylene-3-p-tolyl-7-aza-tricyclo[5.3.0.0*4,8*]decane BDBM50189570 CHEMBL377785
BDBM223134 2-((4′-chloro-[1,1′-biphenyl]-3-yl)methylene)hydrazinecarboxamide (9b)
BDBM50049495 5-(4,6,6-Trimethyl-2-methylene-cyclohex-3-enylmethyl)-benzo[1,2,5]oxadiazole CHEMBL50786
BDBM50049500 1-Nitro-4-(4,6,6-trimethyl-2-methylene-cyclohex-3-enylsulfanyl)-benzene CHEMBL49754
BDBM50049502 5-Bromo-2-(2,2-dimethyl-5-methylene-cyclopentylmethyl)-4-methoxy-phenol CHEMBL48745
BDBM50051767 CHEMBL86963 (1Z,N'E)-N'-((5-(propylamino)pyridin-2-yl)methylene)carbamohydrazonothioic acid
BDBM50051774 CHEMBL87996 (1Z,N'E)-N'-((3-(allylamino)pyridin-2-yl)methylene)carbamohydrazonothioic acid
BDBM50184291 5-((3-(benzyloxy)naphthalen-2-yl)methylene)-2-thioxothiazolidin-4-one CHEMBL206973
BDBM50215531 CHEMBL229534 2-chloro-alpha-[[(4-chlorophenyl)amino]methylene]-N-isopropyl-beta-oxobenzenepropanamide
BDBM50243715 3-((1-methyl-1H-indol-3-yl)methylene)indolin-2-one CHEMBL471375
BDBM50267071 CHEMBL478275 2-Nonyl-4-methylene-5-oxo-tetrahydro-thiophene-3-carboxylic acid
BDBM50267813 (4Z)-4-{[(4-Hydroxybenzyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione CHEMBL489627
BDBM50288289 1-Methanesulfonyl-4-(3-methylene-2-phenyl-cyclobut-1-enyl)-benzene CHEMBL91118
BDBM50325819 CHEMBL1224435 (Z)-5-((2'-(trifluoromethoxy)biphenyl-3-yl)methylene)thiazolidine-2,4-dione
BDBM50327448 7-methyl-2-methylene-4-(3-phenylbuta-1,3-dienyl)-1,2-dihydronaphthalene CHEMBL1258415
BDBM50331890 CHEMBL1290661 E-5-Fluoro-3-[[4-(sulfamoyl)phenyl]methylene]-indolin-2-one
BDBM50331891 E-5-Chloro-3-[[4-(sulfamoyl)phenyl]methylene]-indolin-2-one CHEMBL1290662
BDBM50341691 CHEMBL1766627 N,N'-(Naphthalene-2,6-diylbis(methylene))bis(4,6-dimethylpyridin-2-amine)
BDBM50342855 1,1'-[trans-Cyclopropane-1,2-diylbis(methylene)]bis(4-(dimethylamino)pyridinium bromide CHEMBL1771365
BDBM50342880 1,1',1''-(benzene-1,3,5-triyltris(methylene))tris(4-(dimethylamino)pyridinium)bromide CHEMBL1771553
BDBM58321 (1Z)-1-[(5-tert-butyl-2-hydroxy-anilino)methylene]naphthalen-2-one
CHEMBL1093629 2-((1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one BDBM50315452
CHEMBL1094646 BDBM50318249 (E)-N-(amino(4-methylquinazolin-2-ylamino)methylene)-2-(methylamino)benzamide
CHEMBL1287841 BDBM50331894 E-5-Bromo-3-[[4-(sulfamoyl)phenyl]methylene]-indolin-2-one
CHEMBL1289105 E-5-Nitro-3-[[4-(sulfamoyl)phenyl]methylene]-indolin-2-one BDBM50331895
CHEMBL1289107 BDBM50331897 E-5-Fluoro-3-[[4-(methylsulfonyl)phenyl]methylene]-indolin-2-one
CHEMBL1289225 BDBM50331898 E-5-Chloro-3-[[4-(methylsulfonyl)phenyl]methylene]-indolin-2-one
CHEMBL1289226 E-5-Methyl-3-[[4-(methylsulfonyl)phenyl]methylene]-indolin-2-one BDBM50331899
CHEMBL1289227 BDBM50331900 E-6-Chloro-3-[[4-(methylsulfonyl)phenyl]methylene]-indolin-2-one
CHEMBL133689 2-[(Benzyl-hydroxy-amino)-methylene]-3,4-dihydro-2H-naphthalen-1-one BDBM50003466
CHEMBL240336 BDBM50222538 N'-((6-bromoisoquinolin-4-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide
CHEMBL318362 N-((1E)-amino{methyl[(3-methylphenyl)thio]amino}methylene)-4-methylbenzamide BDBM50107054
CHEMBL318692 4-(3,4-Dichloro-phenyl)-2-methylene-4-oxo-butyric acid CHEMBL99588 BDBM50072253
CHEMBL397105 N'-((7-bromoisoquinolin-4-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide BDBM50222536
CHEMBL397780 BDBM50222526 N'-((8-bromoisoquinolin-4-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide
CHEMBL447758 (4Z)-4-{[(3-Hydroxybenzyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione BDBM50267814
CHEMBL470290 2-[(Benzofuroxan-5-yl)methylene]-1-(5-bromo-2-hydroxybenzylidene)hydrazine BDBM50243054
CHEMBL475472 2-Octyl-4-methylene-5-oxo-tetrahydro-thiophene-3-carboxylic acid BDBM50267033
CHEMBL477462 2-Undecyl-4-methylene-5-oxo-tetrahydro-thiophene-3-carboxylic acid BDBM50267073
CHEMBL478276 2-Decyl-4-methylene-5-oxo-tetrahydro-thiophene-3-carboxylic acid BDBM50267072
CHEMBL48858 5-Bromo-2-(2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenol BDBM50049493
CHEMBL489431 BDBM50267816 4-{[2-(3,4-Dihydroxy-phenyl)-ethylamino]-methylene}-4H-isoquinoline-1,3-dione
CHEMBL50023 1-Nitro-4-(4,6,6-trimethyl-2-methylene-cyclohex-3-enylmethyl)-benzene BDBM50049486
CHEMBL597960 3-((4-(dimethylamino)naphthalen-1-yl)methylene)-4-methylindolin-2-one BDBM50307129
CHEMBL85661 BDBM50051777 (1Z,N'E)-N'-((5-(aminomethyl)pyridin-2-yl)methylene)carbamohydrazonothioic acid
E-5-Bromo-3-[[4-(methylsulfonyl)phenyl]methylene]-indolin-2-one BDBM50331901 CHEMBL1289341
E-5-Methyl-3-[[4-(sulfamoyl)phenyl]methylene]-indolin-2-one CHEMBL1290779 BDBM50331892
E-5-Nitro-3-[[4-(Methylsulfonyl)phenyl]methylene]-indolin-2-one BDBM50331902 CHEMBL1289342
E-6-Chloro-3-[[4-(sulfamoyl)phenyl]methylene]-indolin-2-one CHEMBL1290780 BDBM50331893
2-methylene-1,3,5-triphenylpentane-1,5-dione 2-methylidene-1,3,5-triphenyl-pentane-1,5-dione cid_3715215 BDBM54249 2-methylidene-1,3,5-triphenylpentane-1,5-dione MLS000589466 2-methylene-1,3,5-triphenyl-pentane-1,5-dione SMR000212859
2-methylene-1,5-diphenyl-pentane-1,5-dione 2-methylene-1,5-diphenylpentane-1,5-dione MLS000589465 SMR000212864 2-methylidene-1,5-diphenyl-pentane-1,5-dione 2-methylidene-1,5-diphenylpentane-1,5-dione cid_914917 BDBM33750
US11787766, Compound 9 1,1′-(((((2,2′-dimethyl-[1,1′-biphenyl]-3,3′-diyl) bis (methylene)) bis (oxo))bis (2-methoxypyridine-6,3-diyl)) bis (methylene)) bis (piperidine-2-carboxylic acid) BDBM626244
cid_4599064 BDBM43405 5-(3-chlorophenyl)-2-[(cyclopentylamino)methylidene]cyclohexane-1,3-dione MLS000586114 SMR000204477 5-(3-chlorophenyl)-2-[(cyclopentylamino)methylene]cyclohexane-1,3-quinone 5-(3-chlorophenyl)-2-[(cyclopentylamino)methylene]cyclohexane-1,3-dione
(2E)-2-({1-[(3-(2-cyanobenzenesulfonate)-5-methylphenoxy)methyl]cyclopropyl}methylene)hydrazinecarboximidamide CHEMBL128436 BDBM50083960
(E)-2-(E)-((1H-Indole-3-yl)methylene)hydrazono)thiazolidine-4-one (16) BDBM173603
(E)-5-((5-(2,4-dichlorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione BDBM50308351 CHEMBL590023
(E)-5-((5-(3,4-dichlorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione BDBM50308354 CHEMBL604254
(E)-5-((5-(4-bromophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione CHEMBL602919 BDBM50308348
(E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione CHEMBL590022 BDBM50308349
(R)-1-(4-Butoxy-benzenesulfonyl)-4-methylene-pyrrolidine-2-carboxylic acid hydroxyamide BDBM50084197 CHEMBL151024
(R)-1-(4-Methoxy-benzenesulfonyl)-4-methylene-pyrrolidine-2-carboxylic acid hydroxyamide CHEMBL151399 BDBM50084220
(Z)-3-[Phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-indolin-2-one BDBM50279121 CHEMBL500435
(dipropylamino)methylenediphosphonic acid [(dipropylamino)methylene]-1,1-bisphosphonate CHEMBL55352 (Dipropylamino-phosphono-methyl)-phosphonic acid BDBM50135825
2-({2-[(5-Dimethylaminomethyl-furan-2-ylmethyl)-amino]-ethylamino}-methylamino-methylene)-malononitrile BDBM50047749 CHEMBL155392
2-{[(2-hydroxy-3-{[(2-hydroxyphenyl)methylene]amino}propyl)imino]methyl}phenol BDBM50178753 CHEMBL196968
3-((5-methoxy-1-methylindolin-3-yl)methylene)-2-oxoindoline-5-sulfonamide BDBM50275976 CHEMBL471424
3-(4-chloro-phenyl)-5-methylene-7-aza-tricyclo[5.3.0.0*4,8*]decane CHEMBL378536 BDBM50189574
3-({(1E)-[4-(Dimethylamino)phenyl]methylene}amino)-2-phenylquinazolin-4(3H)-one BDBM50321118 CHEMBL1163745
5-((3-(3,5-dimethoxybenzyloxy)naphthalen-2-yl)methylene)-2-thioxothiazolidin-4-one BDBM50184292 CHEMBL210772
5-((5-(3,5-dichlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one CHEMBL227620 BDBM50211902
BDBM152617 (E)-4-(4-Chlorophenyl)-2-(2-(naphthalene-2-yl-methylene)hydrazinyl)thiazole (6)
BDBM152626 (E)-4-(4-Methoxyphenyl)-2-(2-(naphthalen-2-yl-methylene)-hydrazinyl)thiazole (15)
BDBM50046599 CHEMBL348067 Allyl-(8-methoxy-1-methylene-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amine
BDBM50047756 2-({2-[(5-Methoxymethyl-furan-2-ylmethyl)-amino]-ethylamino}-methylamino-methylene)-malononitrile CHEMBL155495
BDBM50049512 5-Bromo-2-((S)-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenol CHEMBL51669
BDBM50189572 CHEMBL212452 3-(4-bromo-phenyl)-5-methylene-7-aza-tricyclo[5.3.0.0*4,8*]decane
BDBM50189573 CHEMBL380383 3-(4-iodo-phenyl)-5-methylene-7-aza-tricyclo[5.3.0.0*4,8*]decane
BDBM50211907 5-((5-(2,3-dichlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one CHEMBL227563
BDBM50211908 5-((5-(3-chlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one CHEMBL227619
BDBM50265465 NSC-75308 3,4-dichloro-5-(2-((4-methoxyphenyl)(phenyl)methylene)hydrazinyl)pyridazine CHEMBL497614
BDBM50296357 4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methylene)dibenzene-1,2-diol CHEMBL551264
BDBM50296695 CHEMBL537963 N-((9-ethyl-9H-carbazol-3-yl)methylene)-3-fluoro-4-methylaniline
BDBM50328401 (Z)-5-fluoro-3-((3-fluoroazulen-1-yl)methylene)indolin-2-one CHEMBL1257921
BDBM50346125 N-((4,6-dimethylpyrimidin-2-ylamino)(3-nitrophenylamino)methylene)-10H-phenothiazine-10-carboxamide CHEMBL1782310
CAS_9810861 NSC_9810861 BDBM87015 1-(bis(4-chlorophenyl)methyl)-3-((3,5-difluorophenyl)(methylsulfonyl)methylene)azetidine
CHEMBL1164450 BDBM50321119 3-({(1E)-[4-(Dimethylamino)phenyl]methylene}amino)-2-methylquinazolin-4(3H)-one
CHEMBL1257804 (E)-5-fluoro-3-((3-methylazulen-1-yl)methylene)indolin-2-one BDBM50328399
CHEMBL1257805 (Z)-5-fluoro-3-((3-methylazulen-1-yl)methylene)indolin-2-one BDBM50328400
CHEMBL150745 (R)-4-Methylene-1-(4-propoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid hydroxyamide BDBM50084211
CHEMBL279912 BDBM50112399 1-phenyl-5-((2Z)-2-{phenyl[(E)-phenyldiazenyl]methylene}hydrazino)-1H-tetrazole
CHEMBL356011 BDBM50084217 (R)-4-Methylene-1-(4-phenoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid hydroxyamide
CHEMBL368451 BDBM50056841 3-Methylene-5-[4-(morpholine-4-sulfonyl)-phenyl]-dihydro-furan-2-one
CHEMBL565802 BDBM50303178 5-((5-(4-nitrophenyl)furan-2-yl)methylene)-4-thioxothiazolidin-2-one
CHEMBL573861 N,N'-[4,5-Acridindiylbis(methylene)]bis[3-(4-methylpiperazin-1-yl)propanamide] BDBM50298385
CHEMBL591252 (E)-5-((5-(3-bromophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione BDBM50308346
CHEMBL591702 (Z)-5-((5-(2-nitrophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione BDBM50308357
CHEMBL594622 2-Ethyloxycarbonylamino-1-(4-methoxyphenyl)-6,7-methylene-dioxy-2H-isoquinolin-3-one BDBM50304287
CHEMBL602518 (E)-5-((5-(2,3-dichlorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione BDBM50308350
Di-(2-MeS)-adenosine 5',5''-P1,P4,alpha,beta-Methylene-tetraphosphate CHEMBL591433 BDBM50308334
Di-(2-MeS)-adenosine 5',5''-P1,P4,beta,gamma-Methylene-tetraphosphate CHEMBL591434 BDBM50308335
N-(amino(4,6-dimethylpyrimidin-2-ylamino)methylene)-2-(1H-imidazol-4-yl)ethanaminium BDBM50261080
TEGASEROD BDBM50240618 (2E)-2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide CHEMBL76370
[(cyclohexylamino)methylene]-1,1-bisphosphonate (Cyclohexylamino-phosphono-methyl)-phosphonic acid (cyclohexylamino)methylenediphosphonic acid CHEMBL56253 BDBM50115115
MLS000673314 3-[2-[(3-methylthiophen-2-yl)methylidene]hydrazinyl]benzoic acid 3-{(2E)-2-[(3-methylthien-2-yl)methylene]hydrazino}benzoic acid SMR000314555 cid_5025342 3-[2-[(3-methyl-2-thiophenyl)methylidene]hydrazinyl]benzoic acid 3-[N'-[(3-methyl-2-thienyl)methylene]hydrazino]benzoic acid 3-[(N''E)-N''-[(3-methyl-2-thienyl)methylene]hydrazino]benzoic acid 3-[(N'E)-N'-[(3-methyl-2-thienyl)methylene]hydrazino]benzoic acid BDBM49882
1,1′-(((((((2,2′-dimethyl-[1,1′-biphenyl]-3,3′-diyl) bis (methylene)) bis (oxo)) bis (2-methoxypyridine-6,3-diyl)) bis (methylene)) bis (azetanediyl)) bis (2-methylpropane-2-ol) US11787766, Compound 20 BDBM626254
(1R,3S)-5-Methylene-3-p-tolyl-7-aza-tricyclo[5.3.0.0*4,8*]decane CHEMBL101905 BDBM50085506
(4Z)-4-{[(3-Hydroxy-4-methoxybenzyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione CHEMBL489430 BDBM50267815
(E)-N-((1H-Indol-3-yl)methylene)-4-(2,4-diethoxyphenyl)thiazol-2-amine BDBM50255358 CHEMBL480452
(Z)-3-((cyclohexylamino)(phenyl)methylene)-N-ethyl-N-methyl-2-oxoindoline-6-carboxamide BDBM50329818 CHEMBL1272126
(Z)-6-(4-hydroxyphenyl)-3-((5-methylselenophen-2-yl)methylene)indolin-2-one BDBM50325298 CHEMBL1223265
1-{4-[(4-Chloro-phenyl)-pyridin-2-yl-methylene]-piperidin-1-yl}-ethanone CHEMBL140919 BDBM50007469
2-((5-bromo-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one CHEMBL1093930 BDBM50315450
2-((5-chloro-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one CHEMBL1091534 BDBM50315451
4-(3-(3,4-diethylphenyl)buta-1,3-dienyl)-7-ethyl-2-methylene-1,2-dihydronaphthalene BDBM50327447 CHEMBL1258414
5-((4-(4-oxo-4H-chromen-2-yl)phenyl)methylene)thiazolidine-2,4-dione BDBM50292598 CHEMBL494695
5-((4-oxo-2-phenyl-4H-chromen-6-yl)methylene)thiazolidine-2,4-dione BDBM50292597 CHEMBL494058
5-Bromo-2-(6,6-dimethyl-2-methylene-cyclohex-3-enylmethyl)-4-methoxy-phenol BDBM50049494 CHEMBL48358
5-Bromo-4-methoxy-2-((1S,2R)-2-methyl-6-methylene-cyclohexylmethyl)-phenol BDBM50049511 CHEMBL51788
5-Bromo-4-methoxy-2-(2,6,6-trimethyl-4-methylene-cyclohex-2-enylmethyl)-phenol CHEMBL299828 BDBM50049487
5-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-phenyl-1,2,4-oxadiazole CHEMBL571257 BDBM50300262
5-[2,3-Dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-phenyl-1,2,4-oxadiazole CHEMBL568269 BDBM50300251
5-[3-Bromo-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-phenyl-1,2,4-oxadiazole BDBM50300269 CHEMBL571474
5-[3-Chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazole BDBM50300257 CHEMBL568725
6-Methoxy-4-[(4-piperidin-1-ylmethyl-phenylamino)-methylene]-4H-isoquinoline-1,3-dione BDBM50271086 CHEMBL484288
BDBM50010598 CHEMBL91310 1-Methyl-4-(5-methylene-5H-dibenzo[a,d]cyclohepten-10-yl)-piperazine
BDBM50019042 3-(6-Amino-purin-9-yl)-5-hydroxymethyl-4-methylene-cyclopentane-1,2-diol CHEMBL53931
BDBM50049503 5-Bromo-4-methoxy-2-(4,6,6-trimethyl-2-methylene-cyclohex-3-enylmethyl)-phenol CHEMBL48746
BDBM50049513 CHEMBL299778 5-Bromo-4-methoxy-2-((1R,2S)-2-methyl-6-methylene-cyclohexylmethyl)-phenol
BDBM50051770 (1Z,N'E)-N'-((5-amino-4-(morpholinomethyl)pyridin-2-yl)methylene)carbamohydrazonothioic acid CHEMBL85181
BDBM50211935 CHEMBL227981 5-((4-methoxynaphthalen-1-yl)methylene)-3-(4-methoxyphenyl)-2-thioxothiazolidin-4-one
BDBM50217956 CHEMBL242226 (1R,5S)-(+)-5-(3-hydroxyphenyl)-9-methylene-2-phenethyl-2-azabicyclo[3.3.1]nonane
BDBM50251565 1-((4-((4-chlorophenyl)carbamoyl)-3-phenylpiperazin-1-yl)(o-toluidino)methylene)urea CHEMBL511126
BDBM50266546 CHEMBL457551 5-[(6-Methyl-4-oxo-4H-chromen-3-yl)methylene]thiazolidine-2,4-dione
BDBM50266547 CHEMBL457553 5-[(6-Isopropyl-4-oxo-4H-chromen-3-yl)methylene]thiazolidine-2,4-dione
BDBM50267866 CHEMBL489246 4-[(3-Hydroxy-4-methoxy-benzylamino)-methylene]-6-methoxy-4H-isoquinoline-1,3-dione
BDBM50267900 CHEMBL523780 4-[(3-Hydroxy-4-methoxy-benzylamino)-methylene]-6-phenyl-4H-isoquinoline-1,3-dione
BDBM50296453 5-((1H-indol-3-yl)methylene)-2-(3,5-dichlorophenylamino)thiazol-4(5H)-one CHEMBL557113
BDBM50300243 5-[3-Methyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-phenyl-1,2,4-oxadiazole CHEMBL566962
BDBM50300268 CHEMBL569199 5-[3-Bromo-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazole
BDBM50308340 (Z)-5-((6-ethoxybenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione CHEMBL589065
BDBM50308341 CHEMBL589499 (E)-5-((6-bromobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione
BDBM50322366 CHEMBL1171297 1-(4-ethylcyclohexyl)-3-methyl-5-methylene-4,5-dihydro-3H-cyclopenta[a]naphthalene
BDBM50334555 [4(5)S]-4(5)-(2-Aminoethyl)-2-[(naphthyl-1)methylene]imidazoline dihydrobromide CHEMBL1644511
BDBM50334556 [4(5)R]-4(5)-(2-Aminoethyl)-2-[(naphthyl-1)methylene]imidazoline dihydrobromide CHEMBL1644512
BDBM50339267 (Z/E)-3-((3-(7-chloroquinolin-4-ylamino)propylamino)methylene)indolin-2-one CHEMBL1687962
BDBM50342857 1,1'-[1,3-Phenylenebis(methylene)]bis[4-(3,4-dihydroisoquinolin-2(1H)-yl)pyridinium]bromide CHEMBL1771367
BDBM50342867 CHEMBL1771538 1,1'-(biphenyl-4,4'-diylbis(methylene))bis(4-((3,5-dichlorophenyl)(methyl)amino)pyridinium)bromide
BDBM584973 US11529321, Compound 1 Synthesis of Compound 2-((Dimethylamino)Methylene)-5-Phenyl-Cyclohexane-1,3-Dione 
BDBM584983 Synthesis of Compound 5-Phenyl-2-((Phenylamino)Methylene)-Cyclohexane-1,3-Dione US11529321, Compound 11
BDBM602742 (5Z)-5-[(1-phenylpyrazol-4-yl)methylene]thiazolidine-2,4-dione US11649231, Example 1-39
CHEMBL153311 2-{[2-({5-[(Diisopropylamino)-methyl]-furan-2-ylmethyl}-amino)-ethylamino]-methylamino-methylene}-malononitrile BDBM50047733
CHEMBL1668300 1-(4-chlorophenyl)-5-((3-hydroxyphenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione BDBM50336433
CHEMBL1771370 BDBM50342860 1,1'-[1,4-Phenylenebis(methylene)]bis[4-(3,4-dihydroisoquinolin-2(1H)-yl)pyridinium]bromide
CHEMBL239475 N,2-dimethyl-N'-((1-methyl-1H-indol-3-yl)methylene)-5-nitrobenzenesulfonohydrazide BDBM50222532
CHEMBL299512 2-Methyl-1-nitro-4-(4,6,6-trimethyl-2-methylene-cyclohex-3-enylmethyl)-benzene BDBM50049505
CHEMBL311304 BDBM50128620 2-(4-Methoxy-benzenesulfonyl)-2-methyl-4-methylene-hex-5-enoic acid hydroxyamide
CHEMBL397796 N,2-dimethyl-N'-((1-methyl-1H-imidazol-5-yl)methylene)-5-nitrobenzenesulfonohydrazide BDBM50222533
CHEMBL404232 BDBM50321885 aplysinopsin (E)-5-((1H-Indol-3yl)methylene)-2-imino-1,3-dimethylimidazolidin-4-one
CHEMBL437949 BDBM50217947 (1S,5R)-(-)-5-(3-hydroxyphenyl)-9-methylene-2-phenethyl-2-azabicyclo[3.3.1]nonane
CHEMBL482679 (4Z)-4-{[(4-Morpholin-4-ylphenyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione BDBM50270701
CHEMBL565458 BDBM50300258 5-[3-Chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-phenyl-1,2,4-oxadiazole
CHEMBL568260 BDBM50300241 5-[3-Methyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazole
CHEMBL571052 5-[2,3-Dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazole BDBM50300250
CHEMBL577307 5-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazole BDBM50300261
CHEMBL65711 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-methylene-pentanedioic acid BDBM50010925
CHEMBL92443 BDBM50288292 1-(4,4-Dimethyl-3-methylene-2-phenyl-cyclobut-1-enyl)-4-methanesulfonyl-benzene
[(p-Hydroxyanilino)methylene]malononitrile benzylidenemalononitrile (BMN) deriv. 69 2-{[(4-hydroxyphenyl)amino]methylidene}propanedinitrile BDBM4383
[2-Methylene-3-(3-nitro-benzyl)-4,5-dioxo-imidazolidin-1-yl]-acetic acid BDBM50056541 CHEMBL159288
[4-Methylene-3-(3-nitro-benzyl)-2,5-dioxo-imidazolidin-1-yl]-acetic acid CHEMBL433898 BDBM50056525
methyl-(3-methylene-1-phenyl-pent-4-enyl)amine N-methyl-3-methylidene-1-phenyl-pent-4-en-1-amine N-methyl-N-(3-methylene-1-phenylpent-4-enyl)amine N-methyl-3-methylidene-1-phenylpent-4-en-1-amine cid_3241028 MLS000087744 N-methyl-3-methylene-1-phenyl-4-penten-1-amine BDBM41161 SMR000023965
Dehydroleucodin dehydroleucodine BDBM50318392 (3aS,9aS,9bS)-6,9-Dimethyl-3-methylene-3,3a,4,5,9a,9b-hexahydro-azuleno[4,5-b]furan-2,7-dione CHEMBL441260 6,9-Dimethyl-3-methylene-3,3a,4,5,9a,9b-hexahydro-azuleno[4,5-b]furan-2,7-dione
(4Z)-4-({[4-(Piperidin-1-ylmethyl)phenyl]amino}methylene)-isoquinoline-1,3(2H,4H)-dione CHEMBL486284 BDBM50270732
(4Z)-4-{[(3-Hydroxy-4-propoxybenzyl)amino]methylene}-6-iodoisoquinoline-1,3(2H,4H)-dione CHEMBL477861 BDBM50267400
(4Z)-4-{[(4-Methyl-3-hydroxybenzyl)amino]methylene}-6-iodoisoquinoline-1,3(2H,4H)-dione CHEMBL478487 BDBM50267252
(4Z)-6-Bromo-4-{[(3-hydroxy-4propoxybenzyl)amino]methylene}-isoquinoline-1,3(2H,4H)-dione BDBM50267935 CHEMBL485502
(R)-1-[4-(2-Methoxy-ethoxy)-benzenesulfonyl]-4-methylene-pyrrolidine-2-carboxylic acid hydroxyamide BDBM50084210 CHEMBL358405
(S)-5-hydroxy-12b-methyl-4-((pentylamino)methylene)-1,2-dihydrotetraphene-3,6,8,11(4H,12bH)-tetraone BDBM50336351 CHEMBL1668039
(Z)-6,7-Dichloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]indolin-2-one BDBM50303773 CHEMBL569684
(Z)-6-Acetyl-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-indolin-2-one CHEMBL500169 BDBM50279120
(Z)-6-Chloro-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-indolin-2-one BDBM50279083 CHEMBL501752
(Z)-N-ethyl-N-methyl-2-oxo-3-(phenyl(phenylamino)methylene)indoline-6-carboxamide BDBM50329812 CHEMBL1272237
(Z)-methyl 3-((4-(2-(dimethylamino)acetamido)cyclohexylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate CHEMBL483781 BDBM50279353
1,1',1''-(benzene-1,3,5-triyltris(methylene))tris(4-((3,5-dichlorophenyl)(methyl)amino)pyridinium)bromide CHEMBL1771554 BDBM50342881
1,1'-(4,4'-(ethane-1,2-diyl)bis(4,1-phenylene))bis(methylene)bis(4-morpholinopyridinium)bromide BDBM50342870 CHEMBL1771541
1-cyclohexyl-5-methylene-2-oxo-4-phenyl-2,5-dihydro-1H-pyrrole-3-carbonitrile BDBM50326773 CHEMBL1254214
2-((2-(4-fluorophenyl)-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one CHEMBL1089424 BDBM50315442
2-((5-(4-Chlorophenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)cyclohexanone CHEMBL1780078 BDBM50344873
2-((5-(4-Chlorophenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)cyclopentanone BDBM50344879 CHEMBL1780077
4,6-dihydroxy-2-((2-phenyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one BDBM50315444 CHEMBL1089422
4,6-dihydroxy-2-((5-methoxy-1H-indol-3-yl)methylene)benzofuran-3(2H)-one BDBM50315449 CHEMBL1091882
4,6-dihydroxy-2-((5-phenoxy-1H-indol-3-yl)methylene)benzofuran-3(2H)-one BDBM50315448 CHEMBL1091883
4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-(alpha-phenyl methylene)semicarbazide CHEMBL235465 BDBM50221260
4-[(4-Furan-2-yl-3-hydroxy-benzylamino)-methylene]-6-iodo-4Hisoquinoline-1,3-dione BDBM50267254 CHEMBL477877
4-isobutyl-1-mesityl-5-methylene-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonitrile BDBM50326771 CHEMBL1253939
5-((3-(2-chloro-6-fluorobenzyloxy)naphthalen-2-yl)methylene)-2-thioxothiazolidin-4-one CHEMBL206365 BDBM50184296
5-((5-(2,4-dichlorophenyl)furan-2-yl)methylene)-3-methyl-2-thioxothiazolidin-4-one CHEMBL228098 BDBM50211883
5-((5-(3,5-dichlorophenyl)furan-2-yl)methylene)-3-methyl-2-thioxothiazolidin-4-one BDBM50211915 CHEMBL228099
5-((5-(3-chlorophenyl)furan-2-yl)methylene)-3-methyl-2-thioxothiazolidin-4-one BDBM50211924 CHEMBL226812
5-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-(4-chlorobenzyl)-1,2,4-oxadiazol BDBM50300266 CHEMBL576684
5-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-(4-fluorophenyl)-1,2,4-oxadiazol BDBM50300263 CHEMBL571488
5-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-(4-trifluoromethylphenyl)-1,2,4-oxadiazol BDBM50300264 CHEMBL576873
5-[2,3-Dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-chlorobenzyl)-1,2,4-oxadiazol BDBM50300255 CHEMBL571473
5-[3-Bromo-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-trifluoromethylphenyl)-1,2,4-oxadiazol BDBM50300247 CHEMBL584306
5-[3-Chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-trifluoromethylphenyl)-1,2,4-oxadiazol CHEMBL570107 BDBM50300260
5-[3-Methyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-fluorophenyl)-1,2,4-oxadiazol BDBM50300245 CHEMBL569653
5-[3-Methyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-trifluoromethylphenyl)-1,2,4-oxadiazol CHEMBL566519 BDBM50300248
5-{(2Z)-2-[[(E)-(4-isopropylphenyl)diazenyl](phenyl)methylene]hydrazino}-1-phenyl-1H-tetrazole BDBM50112401 CHEMBL23279
5-{(2Z)-2-[[(E)-(4-methylphenyl)diazenyl](phenyl)methylene]hydrazino}-1-phenyl-1H-tetrazole BDBM50112395 CHEMBL283768
BDBM175412 2-(Cyano(1H-tetrazol-5-yl)methylene)-6-methyl-4,6-bis(phenyl)-1,2,5,6-tetrahydronicotinonitrile (2a)
BDBM50010928 CHEMBL308279 2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-propyl]-benzoylamino}-4-methylene-pentanedioic acid
BDBM50010929 CHEMBL307486 2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-4-methylene-pentanedioic acid
BDBM50047751 CHEMBL347539 2-(Methylamino-{2-[(5-pyrrolidin-1-ylmethyl-furan-2-ylmethyl)-amino]-ethylamino}-methylene)-malononitrile
BDBM50049507 5-Bromo-2-((1S,2R,4R)-2,4-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenol CHEMBL50454
BDBM50058585 N-{2-[({(1E)-[5-(4-fluorophenoxy)-2-furyl]methylene}amino)oxy]ethyl}-N-hydroxyurea CHEMBL61583
BDBM50087969 CHEMBL432704 (1-{4-[(Amino-methoxy-methylene)-sulfamoyl]-phenylcarbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester
BDBM50112393 CHEMBL23344 5-{(2Z)-2-[[(E)-(4-secbutylphenyl)diazenyl](phenyl)methylene]hydrazino}-1-phenyl-1H-tetrazole
BDBM50112396 CHEMBL23068 5-{(2Z)-2-[[(E)-(4-cyclohexylphenyl)diazenyl](phenyl)methylene]hydrazino}-1-phenyl-1H-tetrazole
BDBM50112398 5-{(2Z)-2-[[(E)-(4-ethylphenyl)diazenyl](phenyl)methylene]hydrazino}-1-phenyl-1H-tetrazole CHEMBL23324
BDBM50154785 CHEMBL362350 {3-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-1H-isoindol-1-yl}-methylene-amine
BDBM50183404 CHEMBL204035 N'-((2-chloro-6-fluorobenzyloxyamino)methylene)-2-(5-phenyl-2H-tetrazol-2-yl)acetohydrazide
BDBM50211914 CHEMBL388950 5-((5-(3,4-dichlorophenyl)furan-2-yl)methylene)-3-methyl-2-thioxothiazolidin-4-one
BDBM50221273 4-(4,5-dyl)-1-[alpha-(3-pyridyl)methylene]semicarbazideihydro-5-thioxo-1,3,4-thiadiazol-2- CHEMBL395370
BDBM50263643 CHEMBL476575 ethyl 2-(5-((4-acetylphenylamino)methylene)-3-ethyl-4-oxothiazolidin-2-ylidene)-2-cyanoacetate
BDBM50270702 CHEMBL482883 (4Z)-4-({[4-(Morpholin-4-ylmethyl)phenyl]amino}methylene)-isoquinoline-1,3(2H,4H)-dione
BDBM50279082 CHEMBL501751 (Z)-6-Nitro-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-indolin-2-one
BDBM50279119 (Z)-6-Cyano-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-indolin-2-one CHEMBL500952
BDBM50296454 5-((1H-indol-3-yl)methylene)-2-(2,4-dichlorophenylamino)thiazol-4(5H)-one cid_5530131 CHEMBL549295
BDBM50300246 CHEMBL565718 5-[3-Bromo-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-fluorophenyl)-1,2,4-oxadiazol
BDBM50300249 CHEMBL582827 5-[3-Methyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-nitrobenzyl)-1,2,4-oxadiazol
BDBM50300256 CHEMBL568724 5-[2,3-Dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-nitrobenzyl)-1,2,4-oxadiazol
BDBM50300259 CHEMBL582973 5-[3-Chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-fluorophenyl)-1,2,4-oxadiazol
BDBM50300267 5-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-(4-nitrobenzyl)-1,2,4-oxadiazol CHEMBL569892
BDBM50303184 CHEMBL566634 5-((5-(2-bromo-4,5-dimethylphenyl)furan-2-yl)methylene)-2-thioxoimidazolidin-4-one
BDBM50307122 (Z)-4-bromo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)indolin-2-one CHEMBL592651
BDBM50308352 (E)-5-((5-(2-bromo-4-methylphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione CHEMBL592665
BDBM50308353 CHEMBL592666 (E)-5-((5-(3-chloro-4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione
BDBM50315447 CHEMBL1091884 4,6-dihydroxy-2-((2-methyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one
BDBM50321887 (E)-5-[(6-Chloro-1H-indol-3yl)methylene]-2-imino-1,3-dimethylimidazolidin-4-one CHEMBL1173333
BDBM50329799 CHEMBL1272289 (Z)-3-((4-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N-ethyl-2-oxoindoline-6-carboxamide
BDBM50336350 (S)-5-hydroxy-12b-methyl-4-((phenethylamino)methylene)-1,2-dihydrotetraphene-3,6,8,11(4H,12bH)-tetraone CHEMBL1667866
BDBM50339271 (Z/E)-3-((3-(7-chloroquinolin-4-ylamino)propylamino)methylene)-1-methylindolin-2-one CHEMBL1689615
BDBM50342869 1,1'-(4,4'-methylenebis(4,1-phenylene)bis(methylene))bis(4-(piperidin-1-yl)pyridinium)bromide CHEMBL1771540
BDBM673759 Example 995A (cyclobutane-1,1-diyl)bis(methylene) bis(4-methylbenzene-1-sulfonate) US20240150293, Example 995
CHEMBL1091070 4,6-dihydroxy-2-((1-methyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one BDBM50314354
CHEMBL1091864 2-((2-(4-chlorophenyl)-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one BDBM50315441
CHEMBL1173408 BDBM50321884 (Z)-5-((1H-Indol-3yl)methylene)-3-ethyl-2-imino-1-methylimidazolidin-4-one
CHEMBL1213972 BDBM50323864 1-(4-(3-Methoxyphenyl)thiazol-2-yl)-2-((1H-indol-3-yl)-methylene)-hydrazine
CHEMBL1765548 BDBM50342380 3-Amino-thieno[2,3-b]pyridine-2-carboxylic acid naphthalen-1-yl-methylene hydrazide
CHEMBL1771536 1,1'-[Biphenyl-4,4'-diylbis(methylene)]bis[4-(3,4-dihydroisoquinolin-2(1H)-yl)pyridinium]bromide BDBM50342865
CHEMBL1771539 1,1'-(4,4'-methylenebis(4,1-phenylene)bis(methylene))bis(4-(pyrrolidin-1-yl)pyridinium)bromide BDBM50342868
CHEMBL209560 BDBM50189759 5-((5-(2-bromo-4-nitrophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one
CHEMBL23069 5-{(2Z)-2-[[(E)-(4-tertbutylphenyl)diazenyl](phenyl)methylene]hydrazino}-1-phenyl-1H-tetrazole BDBM50112400
CHEMBL278323 BDBM50112394 5-{(2Z)-2-[[(E)-(4-propylphenyl)diazenyl](phenyl)methylene]hydrazino}-1-phenyl-1H-tetrazole
CHEMBL3144632 BDBM50019909 N-[(3-Chloro-phenyl)-(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)-methylene]-acetamide
CHEMBL374386 5-((5-(3-chloro-4-methylphenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one BDBM50211887
CHEMBL379156 (Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione BDBM50189744
CHEMBL437688 BDBM50189766 5-((5-(2-hydroxy-5-nitrophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one
CHEMBL478488 4-{[(2-Hydroxy-biphenyl-4-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione BDBM50267253
CHEMBL497739 (Z)-6-Amino-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-indolin-2-one BDBM50279199
CHEMBL498237 BDBM50279098 (Z)-4-((1H-indol-3-yl)methylene)-2-phenyl-1H-imidazol-5(4H)-one
CHEMBL502651 (4Z)-4-{[(4-Amino-3-hydroxybenzyl)amino]methylene}-6-bromoisoquinoline-1,3(2H,4H)-dione BDBM50267251
CHEMBL504547 4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]-6-iodo-4Hisoquinoline-1,3-dione BDBM50267255
CHEMBL511460 (R)-1-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylacetamido)-5-oxopentylamino)(amino)methylene)-3-ethylurea BDBM50246648
CHEMBL513068 BDBM50244884 5-(1-Oxido-4-pyridinyl)methylene)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-4-thiazolidinone
CHEMBL568727 5-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-(4-methoxyphenyl)-1,2,4-oxadiazol BDBM50300265
CHEMBL569165 (E)-2-((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methylene)-4-methoxybutanoic acid BDBM50303971
CHEMBL569196 BDBM50300252 5-[2,3-Dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-hydroxyphenyl)-1,2,4-oxadiazol
CHEMBL569891 BDBM50300254 5-[2,3-Dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-trifluoromethylphenyl)-1,2,4-oxadiazol
CHEMBL571050 5-[3-Methyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-hydroxyphenyl)-1,2,4-oxadiazol BDBM50300244
CHEMBL579208 5-[2,3-Dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-fluorophenyl)-1,2,4-oxadiazol BDBM50300253
CHEMBL65616 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-methylene-pentanedioic acid BDBM50010924
Example 994A (cyclopropane-1,1-diyl)bis(methylene) bis(4-methylbenzene-1-sulfonate) BDBM673758 US20240150293, Example 994
N'1,N'7-bis((6-nitrobenzo[d][1,3]dioxol-5-yl)methylene)heptanedihydrazide CHEMBL1779065 BDBM50344636
N-{2-[({(1E)-[5-(4-fluorophenoxy)-2-furyl]methylene}amino)oxy]ethyl}-N-hydroxyurea BDBM50058635 CHEMBL60523
Sodium; 8-[bis-(4-fluoro-phenyl)-methylene]-3,5-dihydroxy-9-methyl-dec-6-enoate BDBM50014364 CHEMBL318102
ethyl 2-(5-((m-toluidino)methylene)-3-ethyl-4-oxothiazolidin-2-ylidene)-2-cyanoacetate BDBM50263589 CHEMBL503480
(5R)-5-{(2R)-2-[(1R,3R,7E)-1,3-Dihydroxy-2-methylene-9,10-secoestra-5,7-dien-17-yl]propyl}-3-methylenedihydro-2(3H)-furanone CHEMBL261197 BDBM50292630 (23R)-25-dehydro-2-methylene-19-nor-1alpha-hydroxyvitaminD3-26,23-lactone
6-isobutoxy-2-methylene-4,9-dihydro-3H-carbazol-1-one 2-methylidene-6-(2-methylpropoxy)-4,9-dihydro-3H-carbazol-1-one MLS001163814 SMR000539219 2-methylene-6-(2-methylpropoxy)-4,9-dihydro-3H-carbazol-1-one BDBM66744 cid_874744
MLS001018331 3-methylene-N,N'-diphenyl-cyclopropane-1,2-dicarboxamide 3-methylene-N1,N2-diphenylcyclopropane-1,2-dicarboxamide 3-methylidene-N1,N2-diphenyl-cyclopropane-1,2-dicarboxamide SMR000354525 BDBM90647 cid_4062021 3-methylidene-1-N,2-N-diphenylcyclopropane-1,2-dicarboxamide
cid_3241704 MLS000090106 2-[(2-hydroxyanilino)methylene]indane-1,3-quinone BDBM42723 2-[[(2-hydroxyphenyl)amino]methylidene]indene-1,3-dione SMR000024724 2-{[(2-hydroxyphenyl)amino]methylene}-1H-indene-1,3(2H)-dione 2-[(2-hydroxyanilino)methylidene]indene-1,3-dione
cid_807603 2-[(2,4-dimethoxyanilino)methylene]indane-1,3-quinone 2-[(2,4-dimethoxyanilino)methylidene]indene-1,3-dione 2-{[(2,4-dimethoxyphenyl)amino]methylene}-1H-indene-1,3(2H)-dione 2-[[(2,4-dimethoxyphenyl)amino]methylidene]indene-1,3-dione MLS000534427 BDBM48238 SMR000141863
MLS000336752 3-[(N'E)-N'-[(5-methyl-2-thienyl)methylene]hydrazino]benzoic acid cid_5059109 3-[(N''E)-N''-[(5-methyl-2-thienyl)methylene]hydrazino]benzoic acid 3-[2-[(5-methyl-2-thiophenyl)methylidene]hydrazinyl]benzoic acid 3-[N'-[(5-methyl-2-thienyl)methylene]hydrazino]benzoic acid BDBM49675 3-[2-[(5-methylthiophen-2-yl)methylidene]hydrazinyl]benzoic acid SMR000244067
(2E)-2-[[(2-chlorophenyl)methylamino]methylidene]-4H-1,4-benzothiazin-3-one BDBM53992 MLS000694651 SMR000332963 cid_1475215 (2E)-2-[[(2-chlorobenzyl)amino]methylene]-4H-1,4-benzothiazin-3-one 2-{[(2-chlorobenzyl)amino]methylene}-2H-1,4-benzothiazin-3(4H)-one
5-((5-(4-chlorobenzylthio)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one CHEMBL231740 BDBM50202186 (Z)-5-((5-(4-chlorobenzylthio)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one
6-ethyl-4-methylene-3-(4-methylphenyl)-1H-quinazolin-2-one cid_894041 SMR000091918 MLS000114559 BDBM44714 6-ethyl-4-methylene-3-(p-tolyl)-1H-quinazolin-2-one 6-ethyl-4-methylidene-3-(4-methylphenyl)-1H-quinazolin-2-one
BDBM50195358 CHEMBL223344 reactive blue 2 sodium 1-amino-4-(4-(4-chloro-6-(3-sulfonatophenylamino)-1,3,5-triazin-2-ylamino)-3-sulfonatophenylamino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate
(2-Chloro-benzyl)-methylene-cyanamide-[4-(6,7-dimethoxy-quinazolin-4-yl)-piperazine-1-ylmethyl]-amine CHEMBL424104 BDBM50118844
(3-Chloro-benzyl)-methylene-cyanamide-[4-(6,7-dimethoxy-quinazolin-4-yl)-piperazine-1-ylmethyl]-amine CHEMBL335364 BDBM50118868
(4-methyl-benzyl)-methylene-cyanamide-[4-(6,7-dimethoxy-quinazolin-4-yl)-piperazine-1-ylmethyl]-amine BDBM50118853 CHEMBL140964
(4Z)-5-Bromo-4-{[(3-hydroxy-4-methoxybenzyl)amino]methylene}-isoquinoline-1,3(2H,4H)-dione BDBM50267863 CHEMBL489039
(4Z)-6-bromo-4-{[(4-ethoxy-3-hydroxybenzyl)amino]methylene}-isoquinoline-1,3(2H,4H)-dione CHEMBL484274 BDBM50267937
(E)-1,1'-[4,4'-(Ethene-1,2-diyl)bis(1,4-phenylene)]bis-(methylene)bis(3-hydroxyquinuclidinium)bromide BDBM50342879 CHEMBL1771552
(E)-3-((4-(3-(diethylamino)propoxy)-3-methylazulen-1-yl)methylene)-5-fluoroindolin-2-one BDBM50328407 CHEMBL1258264
(E)-5-[(6-Fluoro-1H-indol-3-yl)methylene]-2-imino-1,3-dimethylimidazolidin-4-one BDBM50321888 CHEMBL1173820
(Lactone3)N-[4-(4-Guanidino-phenyl)-6-methylene-2-oxo-tetrahydro-pyran-3-yl]-benzamide BDBM50003739 CHEMBL134927
(Z)-3-((4-(2-(diethylamino)ethylcarbamoyl)phenylamino)(phenyl)methylene)-N-ethyl-2-oxoindoline-6-carboxamide BDBM50329803 CHEMBL1271524
(Z)-3-((4-(2-(dimethylamino)ethyl)phenylamino)(phenyl)methylene)-N-ethyl-2-oxoindoline-6-carboxamide BDBM50329805 CHEMBL1271577
(Z)-3-((4-(3-(diethylamino)propoxy)-3-methylazulen-1-yl)methylene)-4,5-difluoroindolin-2-one BDBM50328419 CHEMBL1258830
(Z)-3-((4-(3-(dimethylamino)propoxy)-3-methylazulen-1-yl)methylene)-4,5-difluoroindolin-2-one BDBM50328416 CHEMBL1258711
(Z/E)-5-chloro-3-((3-(7-chloroquinolin-4-ylamino)propylamino)methylene)indolin-2-one BDBM50339268 CHEMBL1689612
1,1'-[4,4'-(Butane-1,4-diyl)bis(1,4-phenylene)]bis(methylene)bis(4-(dimethylamino)pyridinium)bromide BDBM50342874 CHEMBL1771545
2-(4-chlorophenylamino)-5-((1-methyl-1H-pyrrol-2-yl)methylene)thiazol-4(5H)-one CHEMBL563983 BDBM50296438
2-[(phenethylamino)methylene]cyclohexane-1,3-quinone 2-[(2-phenylethylamino)methylidene]cyclohexane-1,3-dione BDBM40920 cid_2248605 MLS000108318 SMR000104278
3-((2-ethyl-4-methyl-1H-imidazol-5-yl)methylene)indolin-2-one HTS-05065 CHEMBL382706 BDBM50344215
3-(3-chlorophenyl)-5-((5-(3-chlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one CHEMBL388951 BDBM50211900
3-(3-chlorophenyl)-5-((5-(4-chlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one CHEMBL374387 BDBM50211920
3-Amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxylicacid naphthalen-1-yl-methylene hydrazide CHEMBL1765547 BDBM50342379
3-benzoyl-4-methyl-5-methylene-1-(3-(trifluoromethyl)phenyl)-1H-pyrrol-2(5H)-one BDBM50326774 CHEMBL1254303
4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-(2-furyl)methylene]semicarbazide BDBM50221254 CHEMBL235505
4-[(3-Hydroxy-4-pyridin-3-yl-benzylamino)-methylene]-6-iodo-4H-isoquinoline-1,3-dione BDBM50267398 CHEMBL452447
4-ethyl-5-methylene-2-oxo-1-(2,4,5-trichlorophenyl)-2,5-dihydro-1H-pyrrole-3-carbonitrile BDBM50326760 CHEMBL1253279
4-methylene-D-glutamic acid (2R)-2-amino-4-methylidenepentanedioic acid4-methylidene-D-glutamic acid BDBM50164448 CHEMBL38924
5-((5-bromofuran-2-yl)methylene)-1-(4-fluorophenyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione CHEMBL565596 BDBM50303187
5-Bromo-2-((1R,3R)-3-bromo-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenol CHEMBL51639 BDBM50049497
5-Bromo-2-((1S,4R)-4-hydroxymethyl-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenol BDBM50049501 CHEMBL296156
5-Bromo-2-((1S,5R)-5-hydroxy-2,2,5-trimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenol CHEMBL50534 BDBM50049488
5-Bromo-2-((1S,5R)-5-hydroxy-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenol CHEMBL299766 BDBM50049498
BDBM241995 4,4'-(Ethane-1,2-diylbis(phenylazanediyl))bis(methylene)bis(7,8-dihydroxy-2H-chromen-2-one) (3)
BDBM241999 4,4'-(Ethane-1,2-diylbis(phenylazanediyl))bis(methylene)bis(6,7-dihydroxy-2H-chromen-2-one) (7)
BDBM50005392 CHEMBL366808 8-(5-Methylene-bicyclo[2.1.1]hex-2-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
BDBM50010595 1-(2-Chloro-5-methylene-5H-dibenzo[a,d]cyclohepten-10-yl)-4-methyl-piperazine CHEMBL355107
BDBM50049506 5-Bromo-2-((1S,3R)-3-bromo-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenol CHEMBL51093
BDBM50087923 1-(Toluene-4-sulfonylaminocarbonyl)-pyrrolidine-2-carboxylic acid {4-[(amino-methoxy-methylene)-sulfamoyl]-phenyl}-amide CHEMBL295709
BDBM50087979 CHEMBL52968 N-(Amino-methoxy-methylene)-C-(7,7-dimethyl-2-oxo-bicyclo[2.2.1]hept-1-yl)-methanesulfonamide
BDBM50118841 CHEMBL141257 (4-isopropyl-benzyl)-methylene-cyanamide-[4-(6,7-dimethoxy-quinazolin-4-yl)-piperazine-1-ylmethyl]-amine
BDBM50154221 CHEMBL433966 5-((2E)-2-{[5-(3-carboxy-4-chlorophenyl)-2-furyl]methylene}hydrazino)-2-chlorobenzoic acid
BDBM50178568 1-((3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl)methylene)-2-(3,5-dichloropyridin-4-yl)hydrazine CHEMBL204327
BDBM50182147 CHEMBL205509 4-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-phenyl-1H-pyrazol-5(4H)-one
BDBM50221250 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-(4-bromophenyl)methylene]semicarbazide CHEMBL235474
BDBM50221258 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-(4-chlorophenyl)methylene]semicarbazide CHEMBL394749
BDBM50221261 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-(2-chlorophenyl)methylene]semicarbazide CHEMBL394748
BDBM50221262 CHEMBL235035 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-(2-nitrophenyl)methylene]semicarbazide
BDBM50249488 CHEMBL515916 4-benzyl-N-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene)piperazin-1-amine
BDBM50263445 ethyl 2-cyano-2-(3-ethyl-5-((2-fluorophenylamino)methylene)-4-oxothiazolidin-2-ylidene)acetate CHEMBL476137
BDBM50263587 propyl 2-cyano-2-(3-ethyl-5-((4-hydroxyphenylamino)methylene)-4-oxothiazolidin-2-ylidene)acetate CHEMBL477615
BDBM50267351 4-[(3-Hydroxy-4-pyridin-2-yl-benzylamino)-methylene]-6-iodo-4H-isoquinoline-1,3-dione CHEMBL451298
BDBM50290365 CHEMBL313352 1-(4-Fluoro-phenyl)-3-(N'-[(E)-methylene]benzenesulfonohydrazide)-7-naphthalen-1-ylmethyl-octahydro-indazole
BDBM50321886 (E)-5-[(5,6-Dichloro-1H-indol-3-yl)methylene]-2-imino-1,3-dimethylimidazolidin-4-one CHEMBL1173334
BDBM50326756 CHEMBL1254374 1-(2,6-diisopropylphenyl)-4-methyl-5-methylene-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonitrile
BDBM50326757 CHEMBL1253760 1-(3,5-dichlorophenyl)-4-methyl-5-methylene-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonitrile
BDBM50328405 (E)-3-((4-(3-(dimethylamino)propoxy)-3-methylazulen-1-yl)methylene)-5-fluoroindolin-2-one CHEMBL1258149
BDBM50328413 (E)-3-((4-(3-(dimethylamino)propoxy)-3-methylazulen-1-yl)methylene)-7-fluoroindolin-2-one CHEMBL1258602
BDBM50339270 (Z/E)-7-chloro-3-((3-(7-chloroquinolin-4-ylamino)propylamino)methylene)indolin-2-one CHEMBL1689614
BDBM50342858 CHEMBL1771368 1,1'-[1,3-Phenylenebis(methylene)]bis[4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)pyridinium]bromide
BDBM58317 (6E)-2-methoxy-6-[[N'-(6-morpholinopyrimidin-4-yl)hydrazino]methylene]cyclohexa-2,4-dien-1-one
BDBM602743 US11649231, Example 1-52 (5Z)-5-[[1-(3-pyridyl)pyrazol-4-yl]methylene]thiazolidine-2,4-dione
BDBM602746 (5Z)-5-[[1-(2-pyridyl)pyrazol-3-yl]methylene]thiazolidine-2,4-dione US11649231, Example 1-59
BDBM602747 (5Z)-5-[[1-(4-pyridyl)pyrazol-3-yl]methylene]thiazolidine-2,4-dion US11649231, Example 1-61
CHEMBL1088834 2-((5-bromo-2-methyl-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one BDBM50315446
CHEMBL1223041 (Z)-6-(4-hydroxy-3-methoxyphenyl)-3-((5-methylselenophen-2-yl)methylene)indolin-2-one BDBM50325284
CHEMBL1253938 BDBM50326770 4-isobutyl-5-methylene-2-oxo-1-(2,4,5-trichlorophenyl)-2,5-dihydro-1H-pyrrole-3-carbonitrile
CHEMBL1255603 (E)-3-((4-(3-(dimethylamino)propoxy)-3-methylazulen-1-yl)methylene)-6-fluoroindolin-2-one BDBM50328412
CHEMBL1258150 BDBM50328406 (Z)-3-((4-(3-(dimethylamino)propoxy)-3-methylazulen-1-yl)methylene)-5-fluoroindolin-2-one
CHEMBL1258265 BDBM50328408 (Z)-3-((4-(3-(diethylamino)propoxy)-3-methylazulen-1-yl)methylene)-5-fluoroindolin-2-one
CHEMBL1272021 BDBM50329815 (Z)-N-ethyl-2-oxo-3-((4-(piperidin-1-ylmethyl)phenylamino)methylene)indoline-6-carboxamide
CHEMBL1272076 (Z)-3-((4-(2-(dimethylamino)-N-methylacetamido)phenylamino)methylene)-N-ethyl-2-oxoindoline-6-carboxamide BDBM50329816
CHEMBL146612 BDBM50000273 2-(3,4-Dichloro-phenyl)-1-[2-(3-methylene-pyrrolidin-1-ylmethyl)-piperidin-1-yl]-ethanone
CHEMBL148117 2-(3,4-Dichloro-phenyl)-1-[2-(4-methylene-piperidin-1-ylmethyl)-piperidin-1-yl]-ethanone BDBM50000280
CHEMBL1689613 (Z/E)-6-chloro-3-((3-(7-chloroquinolin-4-ylamino)propylamino)methylene)indolin-2-one BDBM50339269
CHEMBL1771532 1,1'-[1,4-Phenylenebis(methylene)]bis[4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)pyridinium]bromide BDBM50342861
CHEMBL235473 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-(3-bromophenyl)methylene]semicarbazide BDBM50221268
CHEMBL235708 BDBM50221269 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha,alpha-diphenyl methylene]semicarbazide
CHEMBL327713 BDBM50039671 1-Methyl-4-(5-methylene-5H-dibenzo[a,d]cyclohepten-10-yl)-1,2,3,6-tetrahydro-pyridine
CHEMBL342227 2-{(4-Chloro-benzylamino)-[4-(6,7-dimethoxy-quinazolin-4-yl)-piperazin-1-yl]-methylene}-malononitrile BDBM50118825
CHEMBL391326 BDBM50221249 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-(4-nitrophenyl)methylene]semicarbazide
CHEMBL394750 BDBM50221271 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-(4-fluorophenyl)methylene]semicarbazide
CHEMBL466792 (25R)-25-Adamantyl-1alpha,25-dihydroxy-2-methylene-22,23-didehydro-19,26,27-trinor-20-epivitamin D3 BDBM50292705
CHEMBL477860 BDBM50267399 4-[(3-Hydroxy-4-pyridin-4-yl-benzylamino)-methylene]-6-iodo-4H-isoquinoline-1,3-dione
CHEMBL478168 Benzyl-[4-(1,4,8,11tetraaza-cyclotetradec-1-ylmethyl)-benzyl]-amine BDBM50270277 N-[1,4,8,11-Tetraazacyclotetradecanyl-1,4-phenylenebis(methylene)]-benzylamine
CHEMBL482678 (4Z)-4-({[4-(4-Methylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline 1,3(2H,4H)-dione BDBM50270700
CHEMBL489244 BDBM50267864 (4Z)-6-Bromo-4-{[(3-hydroxy-4-methoxybenzyl)amino]methylene}-isoquinoline-1,3(2H,4H)-dione
CHEMBL489245 BDBM50267865 (4Z)-6-Iodo-4-{[(3-hydroxy-4-methoxybenzyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione
CHEMBL489432 (4Z)-6-Fluoro-4-{[(3-hydroxy-4-methoxybenzyl)amino]methylene}-isoquinoline-1,3(2H,4H)-dione BDBM50267817
CHEMBL489631 BDBM50267818 (4Z)-6-Chloro-4-{[(3-hydroxy-4-methoxybenzyl)amino]methylene}-isoquinoline-1,3(2H,4H)-dione
CHEMBL519213 BDBM50279351 (Z)-2-oxo-3-(Phenyl-phenylamino-methylene)-2,3-dihydro-1Hindole-6-carboxylic Acid Methyl Ester
CHEMBL560991 BDBM50296439 2-(4-fluorophenylamino)-5-((1-methyl-1H-pyrrol-2-yl)methylene)thiazol-4(5H)-one
CHEMBL72162 1-(8-Chloro-5-methylene-5H-dibenzo[a,d]cyclohepten-10-yl)-4-methyl-piperazine BDBM50010592
CHEMBL76888 2-(4-Methoxy-benzenesulfonyl)-4-methylene-2-pyridin-3-ylmethyl-hex-5-enoic acid hydroxyamide BDBM50128617
[Benzo(1,3)dioxol]-methylene-cyanamide-[4-(6,7-dimethoxy-quinazolin-4-yl)-piperazine-1-ylmethyl]-amine CHEMBL140702 BDBM50118833
SMR000305205 2-[(isoamylamino)methylene]-5-phenyl-cyclohexane-1,3-quinone 2-[(3-methylbutylamino)methylidene]-5-phenylcyclohexane-1,3-dione 2-{[(3-methylbutyl)amino]methylene}-5-phenylcyclohexane-1,3-dione MLS000723610 cid_3388756 BDBM72425 2-[(3-methylbutylamino)methylidene]-5-phenyl-cyclohexane-1,3-dione
BDBM50001775 cid_5074 (ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-2,3-dihydro-1H-indolizin-5-one 6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one (Ritanserin) CHEMBL267777 RITANSERIN 6-(2-(4-(bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one 6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one 6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-8,8a-dihydro-thiazolo[3,2-a]pyrimidin-5-one (ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one 6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one(Ritanserin) Ritanserine
SMR000457440 2,4,6-trimethyl-N-(4-methylene-3-thia-1-azaspiro[4.5]dec-2-ylidene)aniline 4-methylidene-N-(2,4,6-trimethylphenyl)-3-thia-1-azaspiro[4.5]dec-1-en-2-amine mesityl-(4-methylene-3-thia-1-azaspiro[4.5]dec-1-en-2-yl)amine MLS000851197 BDBM63899 4-methylene-N-(2,4,6-trimethylphenyl)-3-thia-1-azaspiro[4.5]dec-1-en-2-amine cid_2802912
BDBM50029031 CID44285648 CHEMBL223344 basilen blue cibacron blue (mixer, meta and para isomers 1-Amino-4-{4-[4-chloro-6-(3-sulfo-phenylamino)-[1,3,5]triazin-2-ylamino]-3-sulfo-phenylamino}-9,10-dioxo-9,10-dihydro-anthracene-2-sulfonic acid1-Amino-4-{4-[4-chloro-6-(4-sulfo-phenylamino)-[1,3,5]triazin-2-ylamino]-3-sulfo-phenylamino}-9,10-dioxo-9,10-dihydro-anthracene-2-sulfonic acid
2-[(2,3-dimethylanilino)methylene]malonic acid diethyl ester 2-[(2,3-dimethylanilino)methylidene]propanedioic acid diethyl ester diethyl 2-[(2,3-dimethylanilino)methylidene]propanedioate SMR000194110 BDBM33724 cid_2267597 MLS000572611 diethyl 2-[[(2,3-dimethylphenyl)amino]methylidene]propanedioate diethyl {[(2,3-dimethylphenyl)amino]methylene}malonate
3,5-dimethyl-N-[(5-nitro-2-thienyl)methylene]aniline cid_693381 MLS000704158 N-(3,5-dimethylphenyl)-1-(5-nitro-2-thiophenyl)methanimine SMR000228534 (3,5-dimethylphenyl)-[(5-nitro-2-thienyl)methylene]amine N-(3,5-dimethylphenyl)-1-(5-nitrothiophen-2-yl)methanimine BDBM93633
SMR000201614 N-[(2-chlorophenyl)-morpholin-4-yl-methylidene]benzenesulfonamide N-[(2-chlorophenyl)-morpholin-4-ylmethylidene]benzenesulfonamide N-[(2-chlorophenyl)-(4-morpholinyl)methylidene]benzenesulfonamide N-[(2-chlorophenyl)-morpholino-methylene]benzenesulfonamide MLS000582908 BDBM63117 cid_2147244 N-[(2-chlorophenyl)(4-morpholinyl)methylene]benzenesulfonamide
SMR000354795 MLS001018628 1,3,3-trimethyl-2-methylidene-6-nitroindol-5-amine cid_4677543 1,3,3-trimethyl-2-methylene-6-nitro-5-indolamine 1,3,3-trimethyl-2-methylidene-6-nitro-indol-5-amine BDBM34951 (1,3,3-trimethyl-2-methylene-6-nitro-indolin-5-yl)amine
(4Z)-1, 3-Dioxo-4-({[4-(piperidin-1-ylmethyl)phenyl]amino}-methylene)-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile BDBM50271269 CHEMBL483535
(4Z)-4-{[(3-Hydroxy-4-methoxybenzyl)amino]methylene}-6-thien-3-ylisoquinoline-1,3(2H,4H)-dione BDBM50267898 CHEMBL489646
(4Z)-6-Bromo-4-({[(2-methoxypyridin-4-yl)methyl]amino}methylene)-isoquinoline-1,3(2H,4H)-dione CHEMBL490241 BDBM50267541
(4Z)-6-Phenyl-4-({[4-piperidin-1-ylmethyl]phenyl}amino)-methylene)}isoquinoline-1,3(2H,4H)-dione BDBM50271146 CHEMBL487521
(4Z)-N,N-Dimethyl-1,3-dioxo-4-({[4-(piperidinylmethyl)phenyl]-amino}methylene)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide BDBM50271114 CHEMBL486487
(E)-N-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methylene)-8-propoxy-5,6,7,8-tetrahydronaphthalen-2-amine BDBM50206191 CHEMBL240023
(R)-2-methylene-N-(4-(3- (quinazolin-2-ylamino)pyrrolidine-1- carbonyl)phenyl)butanamide US11447493, Example 94 BDBM572129
(Z)-1-((1H-Pyrrol-2-yl)methylene)-6-methylfuro[3,4-c]pyridine-3,4(1H,5H)-dione CHEMBL458935 BDBM50274830
(Z)-1-acetyl-2- ((6-(hydroxymeth- yl)quinolin-2-yl)- methylene)indolin- 3-one BDBM728003 US20250091994, Example 33
(Z)-1-acetyl-2-((4- (morpholinometh- yl)quinolin-2-yl)- methylene)indolin- 3-one BDBM728135 US20250091994, Example 181
(Z)-3-((4-(N-(3-(dimethylamino)propyl)acetamido)phenylamino)methylene)-N-ethyl-2-oxoindoline-6-carboxamide BDBM50329813 CHEMBL1271965
(Z)-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)methylene)-6-(pyrrolidine-2-carbonyl)indolin-2-one BDBM50329786 CHEMBL1271632
(Z)-5-fluoro-3-((3-methyl-4-(2-morpholinoethoxy)azulen-1-yl)methylene)indolin-2-one CHEMBL1257444 BDBM50328403
(Z)-N-benzyl-2-oxo-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)methylene)indoline-6-carboxamide CHEMBL1272022 BDBM50329789
(Z)-N-butyl-2-oxo-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)methylene)indoline-6-carboxamide CHEMBL1271578 BDBM50329785
1-Chloro-3,4-dihydronaphthalene-2-carboxaldehyde guanylhydrazone BDBM50253469 CHEMBL448651 2-[(1-chloro-3,4-dihydronaphthalen-2-yl)methylene]hydrazinecarboximidamide
1-benzyl-5-((5-chloro-2-hydroxyphenylamino)methylene)-4-methyl-2,6-dioxo-1,2,5,6-tetrahydropyridine-3-carbonitrile BDBM50292726 CHEMBL473533
10-[bis(4-methylphenyl)methylene]-4-azatricyclo[5.2.1.0~2,6~]dec-8-ene-3,5-dione BDBM79974 cid_2957057 MLS000537663 SMR000143904
4,6-dihydroxy-2-((2-(naphthalen-2-yl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one CHEMBL1089784 BDBM50315440
4,6-dihydroxy-2-((5-methoxy-2-phenyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one CHEMBL1090115 BDBM50315439
4-(2-methoxyphenyl)-5-((5-methylfuran-2-yl)methylene)-3-phenyl-1H-pyrrol-2(5H)-one BDBM50305689 CHEMBL595977
4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-(4-methoxy phenyl)methylene]semicarbazide BDBM50221259 CHEMBL235236
4-methyl-5-methylene-2-oxo-1-(2-(trifluoromethyl)phenyl)-2,5-dihydro-1H-pyrrole-3-carbonitrile CHEMBL1253617 BDBM50326754
4-{[(4-Hydroxy-5-methoxy-pyrimidin-2-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione CHEMBL477862 BDBM50267401
5-((1,3-diphenyl-5-(thiophen-2-ylmethylthio)-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one BDBM50202190 CHEMBL231752
5-((5-(3-chloro-4-methylphenyl)furan-2-yl)methylene)-3-methyl-2-thioxothiazolidin-4-one CHEMBL228100 BDBM50211888
5-((5-(furan-2-ylmethylthio)-1,3-diphenyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one CHEMBL394026 BDBM50202199
5-(4-Chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene CHEMBL286130 BDBM50076313
5-Bromo-4-methoxy-2-[(E)-3-(4,6,6-trimethyl-2-methylene-cyclohex-3-enyl)-propenyl]-phenol BDBM50049492 CHEMBL49978
6-Cyclopentyl-4-{[(4-hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino]-methylene}-4H-isoquinoline-1,3-dione BDBM50267482 CHEMBL477259
7-(4-isopropylphenyl)-5-[(2- methylene-3-oxo-butyl)amino]-2,3- dihydrobenzofuran-4-carbonitrile BDBM626326 US11787775, Compound 11
BDBM175413 2-(Cyano(1H-tetrazol-5-yl)methylene)-6-methyl-4,6-bis(4'/4''-methylphenyl)-1,2,5,6-tetrahydronicotinonitrile (2b)
BDBM50019916 CHEMBL3144642 2,2-Dichloro-N-[(3-chloro-phenyl)-(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)-methylene]-acetamide
BDBM50049490 CHEMBL54270 Acetic acid 5-bromo-4-methoxy-2-(4,6,6-trimethyl-2-methylene-cyclohex-3-enylmethyl)-phenyl ester
BDBM50087921 CHEMBL53464 N-{4-[(Amino-methoxy-methylene)-sulfamoyl]-phenyl}-3-phenyl-2-(N-Toluene-4-sulfonyl)ureido-propionamide
BDBM50178741 2-(N-(3-chloro-4-methoxyphenyl)methan-8-ylsulfonamido)-N'-((2-hydroxynaphthalen-1-yl)methylene)acetohydrazide CHEMBL198855
BDBM50181735 CHEMBL381101 5-(5-[2-chloro-5-(trifluoromethyl)phenyl]-furan-2-methylene)-3-(benzenesulfonylamino)-4-oxo-2-thionothiazolidine
BDBM50187185 7-(4-fluorobenzyl)-9-hydroxy-5-methoxy-6-methylene-6,7-dihydropyrrolo[3,4-g]quinolin-8-one CHEMBL213852
BDBM50202195 CHEMBL400198 5-((5-(benzylthio)-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one
BDBM50206181 CHEMBL241283 (E)-3-(butylthio)-N-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methylene)-1H-inden-5-amine
BDBM50221252 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-(3-methoxy phenyl)methylene]semicarbazide CHEMBL394938
BDBM50222525 N,2-dimethyl-5-nitro-N'-((5,6,7,8-tetrahydroimidazo[1, 2-a]pyridin-3-yl)methylene)benzenesulfonohydrazide CHEMBL239051
BDBM50267402 4-{[(6-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione CHEMBL477863
BDBM50267479 CHEMBL477063 6-Iodo-4-{[(4-hydroxy-5-methoxy-pyridin-2-ylmethyl)-amino]-methylene}-4H-isoquinoline-1,3-dione
BDBM50267899 (4Z)-6-(3-Furyl)-4-{[(3-hydroxy-4-methoxybenzyl)amino]methylene}-isoquinoline-1,3(2H,4H)-dione CHEMBL489853
BDBM50271087 (4Z)-6-Chloro-4-({[4-(piperidin-1-ylmethyl)phenyl]amino}-methylene)isoquinoline-1,3(2H,4H)-dione CHEMBL486301
BDBM50271089 (4Z)-6-Iodo-4-({[4-(piperidin-1-ylmethyl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione CHEMBL486302
BDBM50271237 (4Z)-6-(3-Methoxyphenyl)-4-({[4-(piperidin--ylmethyl)phenyl]-amino}methylene)-isoquinoline-1,3(2H,4H)-dione CHEMBL482919
BDBM50273031 CHEMBL457184 (E)-2-(5-Fluoro-1-((4-fluoronaphthalen-1-yl)methylene)-1H-inden-3-yl)ethanoic acid
BDBM50273066 CHEMBL456987 (E)-2-(5-Fluoro-1-((4-(methylthio)biphenyl-4-yl)methylene)-1Hinden-3-yl)ethanoic acid
BDBM50273067 CHEMBL457194 (E)-2-(1-((2,4-Difluorobiphenyl-4-yl)methylene)-5-fluoro-1H-inden-3-yl)ethanoic acid
BDBM50278302 CHEMBL470182 2-(5-morpholino-2H-tetrazol-2-yl)-N'-((5-(3-nitrophenyl)furan-2-yl)methylene)acetohydrazide
BDBM50315437 CHEMBL1093446 4,6-dihydroxy-2-((5-methoxy-1-methyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one
BDBM50315443 CHEMBL1089423 4,6-dihydroxy-2-((2-(pyridin-2-yl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one
BDBM50315465 4,6-dihydroxy-2-((1-methyl-2-phenyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one CHEMBL1090130
BDBM50315466 CHEMBL1089653 4,6-dihydroxy-2-((5-methoxy-1,2-dimethyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one
BDBM50328417 CHEMBL1258831 (Z)-4,5-difluoro-3-((3-methyl-4-(3-morpholinopropoxy)azulen-1-yl)methylene)indolin-2-one
BDBM50329800 CHEMBL1272290 (Z)-3-((4-(2-(dimethylamino)-N-methylacetamido)phenylamino)(phenyl)methylene)-N-ethyl-2-oxoindoline-6-carboxamide
BDBM50329808 (Z)-N-ethyl-N-methyl-3-((4-(N-methylmethylsulfonamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxamide CHEMBL1272127
BDBM50329809 CHEMBL1272180 (Z)-3-((3-((diethylamino)methyl)phenylamino)(phenyl)methylene)-N-ethyl-N-methyl-2-oxoindoline-6-carboxamide
BDBM50329817 CHEMBL1272077 (Z)-N-ethyl-N-methyl-3-((1-methylpiperidin-4-ylamino)(phenyl)methylene)-2-oxoindoline-6-carboxamide
BDBM59936 cid_12004474 MLS000585611 SMR000207592 2-{[(1E)-(3,4-dihydroxyphenyl)methylene]amino}-3a,4,7,7a-tetrahydro-1H-4,7-ethanoisoindole-1,3-dione
BDBM728140 US20250091994, Example 186 1-acetyl-2-((4- (morpholine-4- carbonyl)quinolin- 2-yl)methylene)- indolin-3-one
CHEMBL1088835 4,6-dihydroxy-2-((5-methoxy-2-methyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one BDBM50315445
CHEMBL1091071 BDBM50314355 4,6-dihydroxy-2-((1-methyl-4-phenyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one
CHEMBL1172812 BDBM50321883 (E)-3-Ethyl-5-[(6-fluoro-1H-indol-3-yl)methylene]-2-imino-1methylimidazolidin-4-one
CHEMBL1254690 BDBM50326761 1-(2-tert-butylphenyl)-4-isopropyl-5-methylene-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonitrile
CHEMBL1258031 (Z)-5-fluoro-3-((3-methyl-4-(3-morpholinopropoxy)azulen-1-yl)methylene)indolin-2-one BDBM50328404
CHEMBL1271471 (Z)-N-ethyl-3-((4-((ethylamino)methyl)phenylamino)(phenyl)methylene)-N-methyl-2-oxoindoline-6-carboxamide BDBM50329802
CHEMBL1771535 BDBM50342864 1,1'-[Biphenyl-3,3'-diylbis(methylene)]bis[4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)pyridinium]bromide
CHEMBL1771537 BDBM50342866 1,1'-[Biphenyl-4,4'-diylbis(methylene)]bis[4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)pyridinium]bromide
CHEMBL185728 BDBM50155088 3-{3-[(4-Ethylcarbamoyl-phenyl)-phenyl-methylene]-8-aza-bicyclo[3.2.1]oct-8-ylmethyl}-benzoic acid
CHEMBL235466 BDBM50221256 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-(4-hydroxy phenyl)methylene]semicarbazide
CHEMBL235692 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-methyl-a-phenyl methylene]semicarbazide BDBM50221267
CHEMBL370564 {4-[[4-(5-carboxy-pentylsulfamoyl)-2-sulfo-phenyl]-(4-diethylamino-phenyl)-methylene]-cyclohexa-2,5-dienylidene}-diethylammonium BDBM50178132
CHEMBL461940 BDBM50244768 5-[[4-(2H-Tetrazol-5-yl)phenyl]methylene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]-4-thiazolidinone
CHEMBL476907 (4Z)-4-({[4-(3,4-Dimethylpiperazin-1-yl)phenyl]amino}methylene)-6-iodoisoquinoline-1,3(2H,4H)-dione BDBM50270520
CHEMBL477064 4-{[(4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione BDBM50267480
CHEMBL483728 (4Z)-4-({[4-(3,5-Dimethylpiperazin-1-yl)phenyl]amino}methylene)-6-iodoisoquinoline-1,3(2H,4H)-dione BDBM50271270
CHEMBL487326 BDBM50270879 (4Z)-4-({[4-(4-Methylpiperazin-1-yl)phenyl]amino}methylene)-6-phenylisoquinoline-1,3(2H,4H)-dione
CHEMBL487842 rac-(Z)-{2-(Hydroxymethyl)-4-[(4-nitrophenyl)methylene]-5-oxo-2-2,3-dihydrofuryl}methyl 2-Ethylhexanoate BDBM50245082
CHEMBL488706 BDBM50245049 rac-(E)-{2-(Hydroxymethyl)-4-[(4-nitrophenyl)methylene]-5-oxo-2-2,3-dihydrofuryl}methyl 2-Ethylhexanoate
CHEMBL490053 (4Z)-6-Bromo-4-{[(3-hydroxy-4-methoxybenzyl)(methyl)amino]methylene} isoquinoline-1,3(2H,4H)-dione BDBM50267902
CHEMBL497055 (Z)-3-[Phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-6-pyrrol-1-yl-indolin-2-one BDBM50279201
CHEMBL50681 BDBM50087902 1-(Toluene-4-sulfonylaminocarbonyl)-pyrrolidine-2-carboxylic acid ({4-[(amino-methoxy-methylene)-sulfamoyl]-phenylcarbamoyl}-methyl)-amide
CHEMBL508974 (R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylacetamido)-5-oxopentylamino)(amino)methylene)ureido)acetate BDBM50246649
N-(amino(3-hydroxypropylamino)methylene)-2-(4-(2-chlorophenyl)-2-(4-propoxyphenyl)thiophen-3-yl)acetamide BDBM50220314 CHEMBL237063
N-[(3-Chloro-phenyl)-(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)-methylene]-2,2,2-trifluoro-acetamide CHEMBL3144848 BDBM50019919
US20250091994, Example 35 (Z)-1-acetyl-2- ((6-(morpholino- methyl)quinolin- 2-yl)methylene)- indolin-3-one BDBM728005
cid_1873079 BDBM84389 (4E)-4-[[1-(2-hydroxyphenyl)-2,5-dimethyl-pyrrol-3-yl]methylene]-1-phenyl-pyrazolidine-3,5-quinone
(2E)-2-[[(4-hydroxyphenyl)amino]methylidene]cyclohexan-1-one cid_890962 BDBM60383 MLS000088697 (2E)-2-[(4-hydroxyanilino)methylidene]cyclohexan-1-one (2E)-2-[(4-hydroxyanilino)methylidene]-1-cyclohexanone (2E)-2-[(4-hydroxyanilino)methylene]cyclohexanone 2-{[(4-hydroxyphenyl)amino]methylene}cyclohexanone SMR000072714
(2Z)-2-[(8-quinolinylamino)methylidene]-1-benzothiophen-3-one (2Z)-2-[(8-quinolylamino)methylene]benzothiophen-3-one cid_5407397 MLS000530291 2-[(8-quinolinylamino)methylene]-1-benzothiophen-3(2H)-one SMR000135268 (2Z)-2-[(quinolin-8-ylamino)methylidene]-1-benzothiophen-3-one BDBM40197
(3Z)-3-[(2,4-dimethylanilino)methylidene]-2-benzothiophen-1-one BDBM52392 SMR000168563 (3Z)-3-[(2,4-dimethylanilino)methylene]isobenzothiophen-1-one 3-[(2,4-dimethylanilino)methylene]-2-benzothiophen-1(3H)-one MLS000328030 (3Z)-3-[[(2,4-dimethylphenyl)amino]methylidene]-2-benzothiophen-1-one cid_6035880
(3Z)-3-[[(4-fluorophenyl)amino]methylidene]-2-benzothiophen-1-one SMR000168561 cid_5525092 3-[(4-fluoroanilino)methylene]-2-benzothiophen-1(3H)-one (3Z)-3-[(4-fluoroanilino)methylidene]-2-benzothiophen-1-one (3Z)-3-[(4-fluoroanilino)methylene]isobenzothiophen-1-one BDBM75796 MLS000328010
2-[[(1-prop-2-enyl-4-quinolinylidene)amino]methylidene]propanedinitrile 2-{[1-Allyl-1H-quinolin-(4E)-ylideneamino]-methylene}-malononitrile BDBM52802 cid_910872 2-[[(1-allyl-4-quinolylidene)amino]methylene]malononitrile 2-[[(1-prop-2-enylquinolin-4-ylidene)amino]methylidene]propanedinitrile SMR000427184 MLS001030001
2-{[(3-chlorophenyl)amino]methylene}-5-phenylcyclohexane-1,3-dione BDBM68009 2-[[(3-chlorophenyl)amino]methylidene]-5-phenyl-cyclohexane-1,3-dione 2-[(3-chloroanilino)methylene]-5-phenyl-cyclohexane-1,3-quinone cid_3603796 SMR000203699 2-[(3-chloroanilino)methylidene]-5-phenylcyclohexane-1,3-dione MLS000584736
2-{[(4-nitrophenyl)amino]methylene}-1-benzothiophen-3(2H)-one (2Z)-2-[(4-nitroanilino)methylidene]-1-benzothiophen-3-one BDBM63172 (2Z)-2-[(4-nitroanilino)methylene]benzothiophen-3-one MLS000577142 SMR000197251 (2Z)-2-[[(4-nitrophenyl)amino]methylidene]-1-benzothiophen-3-one cid_5782470
3-methoxy-N-[[phenyl(2-pyridyl)methylene]amino]benzamide 3-methoxy-N-[[phenyl(pyridin-2-yl)methylidene]amino]benzamide cid_840468 3-methoxy-N-[[phenyl(2-pyridinyl)methylidene]amino]benzamide SMR000159603 BDBM60226 3-methoxy-N'-[phenyl(2-pyridinyl)methylene]benzohydrazide MLS000544569
BDBM40974 MLS000043274 SMR000019894 (3Z)-3-[(3,4-dimethoxyanilino)methylidene]-1H-indol-2-one (3Z)-3-[(3,4-dimethoxyanilino)methylene]oxindole (3Z)-3-[[(3,4-dimethoxyphenyl)amino]methylidene]-1H-indol-2-one cid_5771508 (3Z)-3-{[(3,4-dimethoxyphenyl)amino]methylene}-1,3-dihydro-2H-indol-2-one
BDBM57293 4-ethoxy-N-[[phenyl(2-pyridinyl)methylidene]amino]benzamide 4-ethoxy-N-[[phenyl(2-pyridyl)methylene]amino]benzamide SMR000159605 4-ethoxy-N-[[phenyl(pyridin-2-yl)methylidene]amino]benzamide cid_840483 4-ethoxy-N'-[phenyl(2-pyridinyl)methylene]benzohydrazide MLS000544568
BDBM60381 2-[(4-hydroxyanilino)methylene]-5,5-dimethyl-cyclohexane-1,3-quinone 2-[[(4-hydroxyphenyl)amino]methylidene]-5,5-dimethyl-cyclohexane-1,3-dione MLS000090104 2-{[(4-hydroxyphenyl)amino]methylene}-5,5-dimethylcyclohexane-1,3-dione cid_3245658 2-[(4-hydroxyanilino)methylidene]-5,5-dimethylcyclohexane-1,3-dione SMR000024722
MLS000755962 cid_6382511 5-methyl-4-{[(2-thienylmethyl)amino]methylene}-2,4-dihydro-3H-pyrazol-3-one BDBM72571 SMR000337642 (4E)-5-methyl-4-[(2-thenylamino)methylene]-2-pyrazolin-3-one (4E)-3-methyl-4-[(thiophen-2-ylmethylamino)methylidene]-1H-pyrazol-5-one
N,N'-bis(2,4-dichlorophenyl)-2-[[2-(dimethylamino)ethylamino]methylene]malonamide cid_4640052 SMR000170052 N,N'-bis(2,4-dichlorophenyl)-2-[[2-(dimethylamino)ethylamino]methylidene]propanediamide N~1~,N~3~-bis(2,4-dichlorophenyl)-2-({[2-(dimethylamino)ethyl]amino}methylene)malonamide MLS000325945 BDBM57366
N-[(6-nitro-1,3-benzodioxol-5-yl)methylene]aniline 1-(6-nitro-1,3-benzodioxol-5-yl)-N-phenyl-methanimine (6-nitro-1,3-benzodioxol-5-yl)methylene-phenyl-amine MLS000575485 1-(6-nitro-1,3-benzodioxol-5-yl)-N-phenylmethanimine SMR000184735 BDBM34730 cid_691620
cid_5714571 SMR000458374 (3Z)-3-[(2-phenyl-1H-imidazol-5-yl)methylidene]-1H-indol-2-one 3-[(2-phenyl-1H-imidazol-4-yl)methylene]-1,3-dihydro-2H-indol-2-one BDBM51304 MLS000834756 (3Z)-3-[(2-phenyl-1H-imidazol-5-yl)methylene]oxindole
cid_5913053 4-{[(2-chlorobenzyl)amino]methylene}-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one BDBM79660 (4Z)-4-[[(2-chlorobenzyl)amino]methylene]-5-(trifluoromethyl)-2-pyrazolin-3-one (4Z)-4-[[(2-chlorophenyl)methylamino]methylidene]-3-(trifluoromethyl)-1H-pyrazol-5-one MLS000594319 SMR000126499
(5E)-1-methyl-5-[(5-nitro-2-furanyl)methylidene]-1,3-diazinane-2,4,6-trione MLS000723836 (5E)-1-methyl-5-[(5-nitro-2-furyl)methylene]pyrimidine-2,4,6(1H,3H,5H)-trione BDBM52705 (5E)-1-methyl-5-[(5-nitrofuran-2-yl)methylidene]-1,3-diazinane-2,4,6-trione cid_1909603 SMR000305431 (5E)-1-methyl-5-[(5-nitro-2-furyl)methylene]barbituric acid (5Z)-1-methyl-5-[(5-nitro-2-furyl)methylene]barbituric acid
BDBM50068031 [(1R,3aS,4R,5S,7aR)-5-(5-Cyano-1-methylene-pentyl)-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl]-acetic acid CHEMBL142455 [5-(5-Cyano-1-methylene-pentyl)-1-(1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl]-acetic acid [5-(5-Cyano-1-methylene-pentyl)-1-(1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl]-acetic acid(HP-19)
4,6-dihydroxy-2-((5-methoxy-1-(3-morpholinopropyl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one BDBM50315458 CHEMBL1093437
4-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-(thiazol-2-yl)-1H-pyrazol-5(4H)-one BDBM50182143 CHEMBL204678
4-((6-bromobenzo[d][1,3]dioxol-5-yl)methylene)-1-(4-iodophenyl)pyrazolidine-3,5-dione BAS-00387275 BDBM50187579 CHEMBL379308
4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-(4-chlorophenyl)-alpha-methyl methylene]semicarbazide CHEMBL391990 BDBM50221265
4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-methyl-alpha-(4-methylphenyl)methylene]semicarbazide BDBM50221263 CHEMBL235700
5-((1-methyl-3-phenyl-5-(p-tolylthio)-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one BDBM50202193 CHEMBL231755
5-((5-(4-chlorobenzylthio)-1-cyclohexyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one BDBM50202194 CHEMBL232565
5-((5-(4-chlorobenzylthio)-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one BDBM50202181 CHEMBL232364
5-((5-(4-fluorophenethoxy)-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one CHEMBL391928 BDBM50202185
6-chloro-N-(4-(4-(cyclopropyl(hydroxy)methylene)-1-(4-fluorobenzyl)-3,5-dioxopyrrolidin-2-yl)butyl)nicotinamide CHEMBL485703 BDBM50279373
BDBM45479 MLS000521471 SMR000131879 (3Z)-3-[(isopropylamino)methylene]oxindole (3Z)-3-[(propan-2-ylamino)methylidene]-1H-indol-2-one cid_9550940
BDBM50182137 4-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-(pyrazin-2-yl)-1H-pyrazol-5(4H)-one CHEMBL380334
BDBM50221248 CHEMBL235913 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-methyl-alpha-(4-methoxyphenyl)methylene]semicarbazide
BDBM50221251 CHEMBL235471 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-(4-hydroxy-3-methoxyphenyl)methylene]semicarbazide
BDBM50221264 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-methyl-alpha-(4-nitrophenyl)methylene]semicarbazide CHEMBL235502
BDBM50221272 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-(4-bromophenyl)-alpha-methyl methylene]semicarbazide CHEMBL235501
CHEMBL1090506 BDBM50315459 2-((1-(3-(dimethylamino)propyl)-5-methoxy-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one
CHEMBL118502 BDBM50053070 (2S,3S,4S)-3-Carboxymethyl-4-{1-[4-(1-methylene-propyl)-phenyl]-vinyl}-pyrrolidine-2-carboxylic acid
CHEMBL204334 BDBM50182136 4-((1-methyl-1H-indol-3-yl)methylene)-3-(thiazol-2-yl)-1H-pyrazol-5(4H)-one
CHEMBL205658 4-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-(furan-3-yl)-1H-pyrazol-5(4H)-one BDBM50182145
CHEMBL233132 5-((5-(4-chlorophenethoxy)-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one BDBM50202200
CHEMBL235485 BDBM50221255 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-(4-N,N-dimethylaminophenyl)methylene]semicarbazide
CHEMBL328199 N-Hydroxy-N-{1-(4-methylene-cyclohexyl)-2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-ethyl}-formamide BDBM50146470
CHEMBL392264 BDBM50202182 5-((5-(2-chlorobenzylthio)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one
CHEMBL393991 BDBM50202192 5-((5-(4-methylpiperazin-1-yl)-1,3-diphenyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one
{2,4-Dioxo-5-[(4-oxo-2-phenyl-4H-chromen-6-yl)-methylene]-1,3-thiazolidine-3yl}acetic acid CHEMBL494490 BDBM50292599