Compile Data Set for Download or QSAR
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Found 139 of ic50 for UniProtKB: Q15369
LigandPNGBDBM536252((2S)-1-((2S,4R)-2-(5-(4-Bromophenyl)-5-methyl-4,5-...)
Affinity DataIC50:  62.8nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536223((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-(4-(4-meth...)
Affinity DataIC50:  202nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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TargetElongin-C(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50590279(CHEMBL4740486)
Affinity DataIC50:  277nMAssay Description:Displacement of (2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(3,3,3-trifluoropropanoyl)pyrrolidine-2-carboxamide from dual VBC E3 ligase (unknown origin) te...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM536223((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-(4-(4-meth...)
Affinity DataIC50:  418nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536284((5S)-2-((4R)-4-hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Affinity DataIC50:  418nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536198(US11242344, Example 104.4)
Affinity DataIC50:  422nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536277(US11242344, Example 1001.2 | US11242344, Example 1...)
Affinity DataIC50:  795nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM50459896(CHEMBL4226250)
Affinity DataIC50:  800nMAssay Description:Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50099062(CHEMBL3344081 | US10730870, Example 3 | US11512083...)
Affinity DataIC50:  800nMAssay Description:Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled...More data for this Ligand-Target Pair
TargetElongin-C(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataIC50:  882nMAssay Description:Displacement of (2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(3,3,3-trifluoropropanoyl)pyrrolidine-2-carboxamide from VBC E3 ligase (unknown origin) binary ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElongin-C(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50590278(CHEMBL5196036)
Affinity DataIC50:  888nMAssay Description:Displacement of (2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(3,3,3-trifluoropropanoyl)pyrrolidine-2-carboxamide from VBC E3 ligase (unknown origin) binary ...More data for this Ligand-Target Pair
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TargetElongin-C(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50014097(CHEMBL3260851)
Affinity DataIC50:  900nMAssay Description:Displacement of FAM-DEALAHyp-YIPD from VHL/elongins-B/elonginC (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetElongin-C(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50590276(CHEMBL5176485)
Affinity DataIC50:  1.04E+3nMAssay Description:Displacement of (2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(3,3,3-trifluoropropanoyl)pyrrolidine-2-carboxamide from VBC E3 ligase (unknown origin) binary ...More data for this Ligand-Target Pair
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TargetElongin-C(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50459881(CHEMBL4226376)
Affinity DataIC50:  1.14E+3nMAssay Description:Displacement of (2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(3,3,3-trifluoropropanoyl)pyrrolidine-2-carboxamide from VBC E3 ligase (unknown origin) binary ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElongin-C(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50459878(CHEMBL4227834)
Affinity DataIC50:  1.21E+3nMAssay Description:Displacement of (2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(3,3,3-trifluoropropanoyl)pyrrolidine-2-carboxamide from VBC E3 ligase (unknown origin) binary ...More data for this Ligand-Target Pair
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LigandPNGBDBM536276((5S)-2-((4R)-4-hydroxy-1-(3-methyl-2-(3-methyl-1,2...)
Affinity DataIC50:  1.62E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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In DepthDetails US Patent
LigandPNGBDBM536254(US11242344, Example 113.4)
Affinity DataIC50:  2.28E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536210(US11242344, Example 106.2 | US11242344, Example 10...)
Affinity DataIC50:  2.96E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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TargetElongin-C(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50590277(CHEMBL5176799)
Affinity DataIC50:  3.02E+3nMAssay Description:Displacement of (2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(3,3,3-trifluoropropanoyl)pyrrolidine-2-carboxamide from VBC E3 ligase (unknown origin) binary ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetElongin-C(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50446138(CHEMBL3108881)
Affinity DataIC50:  4.10E+3nMAssay Description:Displacement of FAM-DEALAHyp-YIPD from 6xHis-tagged VHL (1 to 213)/elongins-B/elonginC (unknown origin) expressed in Escherichia coli BL21 after 1 mi...More data for this Ligand-Target Pair
LigandPNGBDBM536268((5S)-2-((4R)-4-hydroxy-1-(2-(3-hydroxyisoxazol-5- ...)
Affinity DataIC50:  4.35E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536183(2-((2S)-1-((4R)-4-hydroxy-2-((S)-5-methyl-5-(4-(4-...)
Affinity DataIC50:  4.68E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM50459898(CHEMBL4227907)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM536240(1-Cyano-N-((2S)-1-((4R)-4-hydroxy-2-((S)-5-methyl-...)
Affinity DataIC50:  4.97E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536206(US11242344, Example 105.4)
Affinity DataIC50:  5.39E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM50459907(CHEMBL4225691)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM536178(N-((2S)-1-((4R)-4-Hydroxy-2-(5-methyl-5-(4-(4-meth...)
Affinity DataIC50:  6.17E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536297(US11242344, Example 1004.4)
Affinity DataIC50:  6.25E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536291((5S)-2-((4R)-1-(2-(3-((6-(2-((4-((3-Ethynylphenyl)...)
Affinity DataIC50:  6.25E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536250((2R)-1-((2S,4R)-2-(5-(4-Bromophenyl)-5-methyl-4,5-...)
Affinity DataIC50:  6.30E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536190(US11242344, Example 103.4)
Affinity DataIC50:  6.73E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536259(1-((2S,4R)-2-(5,5-dimethyl-1-phenyl-4,5-dihydro-1H...)
Affinity DataIC50:  9.32E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM50459913(CHEMBL4227623)
Affinity DataIC50:  9.90E+3nMAssay Description:Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM536271(1-((2S,4R)-2-((R)-5-(2′-fluoro-[1,1′-b...)
Affinity DataIC50:  1.00E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536226(US11242344, Example 108.2)
Affinity DataIC50:  1.10E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM50459906(CHEMBL4226773)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM536179((5S)-2-((4R)-4-hydroxy-1-((S)-1-(methylsulfonyl)pi...)
Affinity DataIC50:  1.67E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536275(US11242344, Example 1001.1)
Affinity DataIC50:  1.69E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536215((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-phenyl-4,5...)
Affinity DataIC50:  1.73E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536231((2R)-1-((2S,4R)-2-(2,3-dihydro-4'H-spiro[indene-1,...)
Affinity DataIC50:  1.75E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536231((2R)-1-((2S,4R)-2-(2,3-dihydro-4'H-spiro[indene-1,...)
Affinity DataIC50:  1.76E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536239((2R)-1-((4R)-2-(3,4-dihydro-2H,4'H-spiro[naphthale...)
Affinity DataIC50:  1.96E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM536239((2R)-1-((4R)-2-(3,4-dihydro-2H,4'H-spiro[naphthale...)
Affinity DataIC50:  1.99E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM536232((5S)-2-((4R)-4-Hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Affinity DataIC50:  2.06E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536244((5S)-2-((4R)-4-hydroxy-1-((methylsulfonyl)-L-proly...)
Affinity DataIC50:  2.33E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536218(US11242344, Example 107.2 | US11242344, Example 10...)
Affinity DataIC50:  2.41E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50459899(CHEMBL4226398)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM536287(US11242344, Example 1003.3)
Affinity DataIC50:  3.04E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536203((R)-1-((2S,4R)-2-(5,5-dimethyl-4,5-dihydro-1,2,4-o...)
Affinity DataIC50:  3.14E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536187((5S)-2-((4R)-1-(1-acetylpiperidine-2-carbonyl)-4-h...)
Affinity DataIC50:  3.29E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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