Compile Data Set for Download or QSAR
Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 3312
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31270BDBM31270(CHEMBL360141 | isoindolinone scaffold, 65)
Affinity DataIC50: 1.44E+4nMAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31251BDBM31251(CHEMBL178106 | isoindolinone scaffold, 40)
Affinity DataIC50: 1.79E+4nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31230BDBM31230(CHEMBL179549 | isoindolinone scaffold, 16)
Affinity DataIC50: 2.70E+4nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31241BDBM31241(isoindolinone scaffold, 30)
Affinity DataIC50: 5.80E+4nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31268BDBM31268(isoindolinone scaffold, 63)
Affinity DataIC50: 6.43E+4nMAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31231BDBM31231(CHEMBL360920 | isoindolinone scaffold, 17)
Affinity DataIC50: 6.60E+4nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31266BDBM31266(isoindolinone scaffold, 61)
Affinity DataIC50: 6.97E+4nMAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31262BDBM31262(isoindolinone scaffold, 57)
Affinity DataIC50: 7.00E+4nMAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31232BDBM31232(CHEMBL179114 | isoindolinone scaffold, 18)
Affinity DataIC50: 7.00E+4nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31264BDBM31264(isoindolinone scaffold, 59)
Affinity DataIC50: 7.01E+4nMAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31265BDBM31265(isoindolinone scaffold, 60)
Affinity DataIC50: 7.02E+4nMAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31267BDBM31267(isoindolinone scaffold, 62)
Affinity DataIC50: 7.43E+4nMAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31236BDBM31236(isoindolinone scaffold, 22)
Affinity DataIC50: 7.80E+4nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31237BDBM31237(isoindolinone scaffold, 24)
Affinity DataIC50: 7.90E+4nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31229BDBM31229(isoindolinone scaffold, 15)
Affinity DataIC50: 8.50E+4nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31258BDBM31258(isoindolinone scaffold, 49)
Affinity DataIC50: 8.80E+4nMAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31228BDBM31228(CHEMBL182052 | isoindolinone scaffold, 14)
Affinity DataIC50: 9.00E+4nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31227BDBM31227(CHEMBL181688 | isoindolinone scaffold, 13)
Affinity DataIC50: 9.20E+4nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31246BDBM31246(isoindolinone scaffold, 35)
Affinity DataIC50: 9.60E+4nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31245BDBM31245(isoindolinone scaffold, 34)
Affinity DataIC50: 9.70E+4nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31269BDBM31269(isoindolinone scaffold, 64)
Affinity DataIC50: 1.03E+5nMAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31271BDBM31271(isoindolinone scaffold, 67)
Affinity DataIC50: 1.03E+5nMAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31247BDBM31247(isoindolinone scaffold, 36)
Affinity DataIC50: 1.16E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31256BDBM31256(isoindolinone scaffold, 47)
Affinity DataIC50: 1.81E+5nMAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31249BDBM31249(isoindolinone scaffold, 38)
Affinity DataIC50: 1.91E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31242BDBM31242(isoindolinone scaffold, 31)
Affinity DataIC50: 2.06E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31244BDBM31244(isoindolinone scaffold, 33)
Affinity DataIC50: 2.14E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31243BDBM31243(isoindolinone scaffold, 32)
Affinity DataIC50: 2.21E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31250BDBM31250(isoindolinone scaffold, 39)
Affinity DataIC50: 2.32E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31248BDBM31248(isoindolinone scaffold, 37)
Affinity DataIC50: 2.43E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31259BDBM31259(isoindolinone scaffold, 50)
Affinity DataIC50: 2.75E+5nMAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31239BDBM31239(isoindolinone scaffold, 26)
Affinity DataIC50: 2.81E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31233BDBM31233(isoindolinone scaffold, 19)
Affinity DataIC50: 2.84E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31263BDBM31263(isoindolinone scaffold, 58)
Affinity DataIC50: 2.90E+5nMAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31238BDBM31238(isoindolinone scaffold, 25)
Affinity DataIC50: 3.11E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31240BDBM31240(isoindolinone scaffold, 28)
Affinity DataIC50: 3.15E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31253BDBM31253(isoindolinone scaffold, 43)
Affinity DataIC50: 3.26E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31252BDBM31252(isoindolinone scaffold, 41)
Affinity DataIC50: 3.45E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31260BDBM31260(isoindolinone scaffold, 51)
Affinity DataIC50: 3.80E+5nMAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31234BDBM31234(isoindolinone scaffold, 20)
Affinity DataIC50: 3.93E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31257BDBM31257(isoindolinone scaffold, 48)
Affinity DataIC50: 4.13E+5nMAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31235BDBM31235(isoindolinone scaffold, 21)
Affinity DataIC50: 4.39E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31254BDBM31254(isoindolinone scaffold, 44)
Affinity DataIC50: 4.90E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31255BDBM31255(isoindolinone scaffold, 45)
Affinity DataIC50: 5.00E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandChemical structure of BindingDB Monomer ID 31261BDBM31261(isoindolinone scaffold, 53)
Affinity DataIC50: 5.00E+5nMAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed