Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50031677
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317108(2-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50304619(2-(1-{(2S)-3-[(6-Chloronaphthalene-2-yl)sulfonyl]-...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317098(TAK-442 | 1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)s...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human factor 10a using S2222 as substrate after 10 mins by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317107(2-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317098(TAK-442 | 1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)s...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317096(4-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50270656(2-(1-(3-(6-chloronaphthalen-2-ylsulfonyl)propanoyl...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50304620(2-(1-{3-[(6-Chloronaphthalene-2-yl)sulfonyl]propan...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317095(1'-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2-h...)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317092(1-(1-{3-[(6-Chloronaphthalen-2-yl)sulfonyl]propano...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317101(1-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317097(3-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50304621(2-(1-{(2R)-3-[(6-Chloronaphthalene-2-yl)sulfonyl]-...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317104(1-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317106((7aS)-2-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfo...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317093(1-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317103(1-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50: 46nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317094(2-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50: 49nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317105((7aR)-2-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfo...)
Affinity DataIC50: 51nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317102(3-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317099((2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-1-oxo-1...)
Affinity DataIC50: 147nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317100((2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-1-[4-(1...)
Affinity DataIC50: 198nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetProthrombin(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317098(TAK-442 | 1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)s...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human thrombin after 10 mins by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCoagulation factor IX(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317098(TAK-442 | 1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)s...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human factor 9a after 10 mins by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317098(TAK-442 | 1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)s...)
Affinity DataIC50: 4.40E+4nMAssay Description:Inhibition of human tissue plasminogen activator after 5 mins by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetPlasminogen(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317098(TAK-442 | 1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)s...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human plasmin after 5 mins by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed