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TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50064333(Phosphoric acid mono-(2-amino-4-{2-amino-2-[1-(1,2...)
Affinity DataIC50: 0.00400nMAssay Description:Inhibition of binding to Growth factor receptor bound protein 2 (Grb2) SH2 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50139764(5-Methylindolyl derivative | CHEMBL423988)
Affinity DataKd:  0.0750nMAssay Description:In vitro binding affinity for Grb2 SH2 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50139762([(16R,20S)-18-((S)-Carbamoylmethyl)-14-(5-methyl-i...)
Affinity DataKd:  0.0750nMAssay Description:Binding affinity to SH2 domain of GRB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50139762([(16R,20S)-18-((S)-Carbamoylmethyl)-14-(5-methyl-i...)
Affinity DataKd:  0.0930nMAssay Description:In vitro binding affinity for Grb2 SH2 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50161189((S)-4-{5-[(S)-2-Carbamoyl-1-(3-naphthalen-1-yl-pro...)
Affinity DataKd:  0.0970nMAssay Description:In vitro binding affinity for growth factor receptor bound protein 2 SH2 domain from human breast cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50073913({4-[(S)-2-Acetylamino-2-(1-{(S)-2-carbamoyl-1-[3-(...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of Grb-SH2 domain binding to phosphorylated carboxy-terminal intracellular domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50073909({4-[(S)-2-Acetylamino-2-(1-{(S)-2-carbamoyl-1-[3-(...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Grb-SH2 domain binding to phosphorylated carboxy-terminal intracellular domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50073917({4-[(S)-2-Acetylamino-2-(1-{(S)-2-carbamoyl-1-[3-(...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of Grb-SH2 domain binding to phosphorylated carboxy-terminal intracellular domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50078348([(S)-1-[1-((S)-1,2-Dicarbamoyl-ethylcarbamoyl)-cyc...)
Affinity DataIC50: 1nMAssay Description:Binding affinity to Grb2 SH2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50078348([(S)-1-[1-((S)-1,2-Dicarbamoyl-ethylcarbamoyl)-cyc...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Grb2-SH2 domain binding to phospho-EGF receptor intracellular C-terminal domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50064333(Phosphoric acid mono-(2-amino-4-{2-amino-2-[1-(1,2...)
Affinity DataIC50: 1nMAssay Description:Inhibition of binding to Grb2 SH2 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50193153(({4-[(2S)-2-[(1-{[(1S)-2-carbamoyl-1-({3-[1-({[(1S...)
Affinity DataKd:  1.10nMAssay Description:Binding affinity to Grb2-SH2 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50073918([4-((S)-2-Acetylamino-2-{1-[(S)-2-carbamoyl-1-(3-i...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Grb-SH2 domain binding to phosphorylated carboxy-terminal intracellular domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50139763([(E)-(S)-18-Carbamoylmethyl-14-naphthalen-1-ylmeth...)
Affinity DataIC50: 1.40nMAssay Description:In vitro Growth factor receptor bound protein 2-binding affinity in in surface plasmon resonance (SPR) methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50139763([(E)-(S)-18-Carbamoylmethyl-14-naphthalen-1-ylmeth...)
Affinity DataIC50: 1.40nMAssay Description:In vitro Growth factor receptor bound protein 2-binding affinity in in surface plasmon resonance (SPR) methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50139762([(16R,20S)-18-((S)-Carbamoylmethyl)-14-(5-methyl-i...)
Affinity DataKd:  1.47nMAssay Description:Dissociation constant value against growth factor receptor bound protein 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50078347([(S)-1-[1-((1R,6S)-6-Carbamoyl-cyclohex-2-enylcarb...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of Grb2-SH2 domain binding to phospho-EGF receptor intracellular C-terminal domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50078347([(S)-1-[1-((1R,6S)-6-Carbamoyl-cyclohex-2-enylcarb...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of Grb2-SH2 domain binding to phospho-EGF receptor intracellular C-terminal domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50124296(12-benzyl-36-carbamoylmethyl-9-(4-phosphonooxybenz...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of Growth factor receptor-bound protein 2 (Grb2) SH2 domain binding by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50193151(({4-[(5'S,11'S,24'S,30'S)-11',30'-bis(carbamoylmet...)
Affinity DataKd:  1.80nMAssay Description:Binding affinity to Grb2-SH2 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50085869(N-[1-(1-{2-Carbamoyl-1-[3-(5-methyl-indol-1-yl)-pr...)
Affinity DataIC50: 2nMAssay Description:Inhibition of Growth factor receptor bound protein 2 binding by ELISA assay methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50139763([(E)-(S)-18-Carbamoylmethyl-14-naphthalen-1-ylmeth...)
Affinity DataIC50: 2nMAssay Description:In vitro binding affinity in extracellular ELISA-based assay for Grb2 SH2 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50139763([(E)-(S)-18-Carbamoylmethyl-14-naphthalen-1-ylmeth...)
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-fused Grb2-SH2 domain (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50122796([18-Carbamoylmethyl-14-(2,3-dihydro-naphthalen-1-y...)
Affinity DataIC50: 2nMAssay Description:Inhibition against Growth factor receptor bound protein 2 binding using ELISA techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50161189((S)-4-{5-[(S)-2-Carbamoyl-1-(3-naphthalen-1-yl-pro...)
Affinity DataKd:  2.28nMAssay Description:In vitro binding affinity for growth factor receptor bound protein 2 SH2 domain from human breast cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50161189((S)-4-{5-[(S)-2-Carbamoyl-1-(3-naphthalen-1-yl-pro...)
Affinity DataKd:  2.28nMAssay Description:In vitro binding affinity for growth factor receptor bound protein 2 SH2 domain from human breast cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50080832([1-[1-(1,2-Dicarbamoyl-ethylcarbamoyl)-1-methyl-2-...)
Affinity DataKd:  3nMAssay Description:The compound was tested on a LS250B Perkin-Elmer fluorimeter for Growth factor receptor bound protein 2 equilibrium constant(Kd) by the Michaelis-Men...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50168312(2-{4-[(16R,20S)-18-((S)-Carbamoylmethyl)-9-carboxy...)
Affinity DataIC50: 3.30nMAssay Description:Inhibitory concentration against growth factor receptor bound protein 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50073911({4-[(S)-2-Acetylamino-2-(1-{(S)-2-carbamoyl-1-[3-(...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of Grb-SH2 domain binding to phosphorylated carboxy-terminal intracellular domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50168312(2-{4-[(16R,20S)-18-((S)-Carbamoylmethyl)-9-carboxy...)
Affinity DataKd:  3.62nMAssay Description:Dissociation constant value against growth factor receptor bound protein 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50124301(2-[9-(4-phosphonooxybenzyl)-21-carbamoyl-24-(4-hyd...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of Growth factor receptor-bound protein 2 (Grb2) SH2 domain binding by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50073909({4-[(S)-2-Acetylamino-2-(1-{(S)-2-carbamoyl-1-[3-(...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Growth factor receptor bound protein 2 binding by ELISA assay methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50143944(2-[4-((E)-(9S,10S,14S,18S)-18-Carbamoylmethyl-9-ca...)
Affinity DataIC50: 4.30nMAssay Description:In vitro Growth factor receptor bound protein 2-binding affinity in ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50161189((S)-4-{5-[(S)-2-Carbamoyl-1-(3-naphthalen-1-yl-pro...)
Affinity DataKd:  4.30nMAssay Description:In vitro binding affinity for growth factor receptor bound protein 2 SH2 domain from human breast cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50580855(CHEMBL1205233)
Affinity DataIC50: 4.30nMAssay Description:Binding affinity to Grb2-SH2 domain (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50489113(CHEMBL2296610)
Affinity DataKd:  6.30nMAssay Description:Binding affinity to Grb2-SH2 (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50168318([(15R,20S)-18-Carbamoylmethyl-10-[4-(hydroxy-methy...)
Affinity DataIC50: 6.30nMAssay Description:Inhibitory concentration against growth factor receptor bound protein 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50075017(Phosphoric acid mono-[4-((R)-2-acetylamino-2-{1-[(...)
Affinity DataIC50: 7nMAssay Description:Inhibitory concentration against Growth factor receptor bound protein 2 in MDA-MB-453 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50124293(2-[6'-(4-phosphonooxybenzyl)-27'-carbamoyl-24'-(4-...)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of Growth factor receptor-bound protein 2 (Grb2) SH2 domain binding by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50336688(N2-{[1-({(2R)-2-carboxymethyl-3-[4-phosphonomethyl...)
Affinity DataIC50: 8nMAssay Description:Displacement of biotin-Ahx-PSpYVNVQN from Grb2-SH2 by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50085874(2-{4-[2-(1-{2-Carbamoyl-1-[3-(5-methyl-indol-1-yl)...)
Affinity DataIC50: 8nMAssay Description:Inhibitory concentration required against Src homology (SH2) domain of Growth factor receptor bound protein 2 by ELISA binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50118687(N-{1-[(S)-2-Carbamoyl-1-(3-naphthalen-1-yl-propylc...)
Affinity DataIC50: 8nMAssay Description:Binding affinity for Growth factor receptor bound protein 2 SH2 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50122792([3-Carbamoylmethyl-14-(2,3-dihydro-naphthalen-1-yl...)
Affinity DataIC50: 8nMAssay Description:Inhibition against Growth factor receptor bound protein 2 binding using ELISA techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50085874(2-{4-[2-(1-{2-Carbamoyl-1-[3-(5-methyl-indol-1-yl)...)
Affinity DataIC50: 8nMAssay Description:Inhibition of Growth factor receptor bound protein 2 binding by ELISA assay methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50124291(3-[17-carbamoyl-32-carbamoylmethyl-20-(4-hydroxybe...)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of Growth factor receptor-bound protein 2 (Grb2) SH2 domain binding by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50168317([(15R,20S)-10-[4-(Benzyl-hydroxy-phosphinoylmethyl...)
Affinity DataIC50: 8.40nMAssay Description:Inhibitory concentration against growth factor receptor bound protein 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50168316(N-{4-[(7S,14R,18S)-18-Carbamoylmethyl-9-carboxymet...)
Affinity DataIC50: 8.80nMAssay Description:Inhibitory concentration against growth factor receptor bound protein 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50072865(N-[1-{1-[(S)-2-Carbamoyl-1-(3-naphthalen-1-yl-prop...)
Affinity DataIC50: 9nMAssay Description:Binding affinity for Growth factor receptor bound protein 2 SH2 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50073912({4-[(S)-2-Acetylamino-2-(1-{(S)-2-carbamoyl-1-[3-(...)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of Grb-SH2 domain binding to phosphorylated carboxy-terminal intracellular domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50072865(N-[1-{1-[(S)-2-Carbamoyl-1-(3-naphthalen-1-yl-prop...)
Affinity DataIC50: 10nMAssay Description:In vitro Growth factor receptor bound protein 2-binding affinity in ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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