TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of MALT1 (329-824 residues) (unknown origin) using PT14 as substrate incubated for 60 mins by fluorescence based assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of NK3 receptor (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of MALT1 (340 to 789 residues) (unknown origin) using Ac-LRSR-AMC as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Antagonist activity at endothelin A receptor in rat A7r5 cells assessed as inhibition of ET-1-induced increase in cytosolic free Ca2+ level treated 1...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Antagonist activity at mouse TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced current at holding potential of -40 mV by W...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced current at holding potential of -40 mV by W...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:Antagonist activity at endothelin A receptor in Wistar rat thoracic aorta strips assessed as inhibition of ET1-induced vasoconstriction preincubated ...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of NK2 receptor (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 133nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced current at holding potential of -40 mV by Who...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair