Compile Data Set for Download or QSAR
Report error Found 477 Enz. Inhib. hit(s) with Target = 'Protein-tyrosine kinase 6'
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM514126(US11052091, Example 5-1)
Affinity DataIC50: 2nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  2nMAssay Description:Binding affinity to human BRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50273637(3-(4-amino-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  2nMAssay Description:Binding affinity to human BRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM514134(US11052091, Example 5-16)
Affinity DataIC50: 2nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50354414(CHEMBL1836842)
Affinity DataIC50: 2nMAssay Description:Inhibition of BRK pretreated for 30 mins by microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM581757(US11512087, Example 1)
Affinity DataIC50: 2.10nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50610910(CHEMBL5280844)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of BRK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human BRK using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50354416(CHEMBL1836863)
Affinity DataIC50: 3nMAssay Description:Inhibition of BRK pretreated for 30 mins by microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50354415(CHEMBL1836854)
Affinity DataIC50: 3nMAssay Description:Inhibition of BRK pretreated for 30 mins by microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50354432(CHEMBL1836844)
Affinity DataIC50: 3nMAssay Description:Inhibition of BRK pretreated for 30 mins by microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50354412(CHEMBL1836806)
Affinity DataIC50: 3nMAssay Description:Inhibition of BRK pretreated for 30 mins by microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM514135(US11052091, Example 5-17)
Affinity DataIC50: 3nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM514136(US11052091, Example 5-18)
Affinity DataIC50: 3nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM514137(US11052091, Example 5-19)
Affinity DataIC50: 3nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50001733(CHEMBL3133821)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of Brk (unknown origin) using [gamma-33P]-ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)
Affinity DataIC50: 3.30nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 3.30nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM581831(US11512087, Example 13-1)
Affinity DataIC50: 3.30nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)
Affinity DataIC50: 3.30nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)
Affinity DataIC50: 3.30nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 3.30nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 3.30nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM581837(US11512087, Example 25)
Affinity DataIC50: 3.40nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM581838(US11512087, Example 26-1)
Affinity DataIC50: 3.70nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM581832(US11512087, Example 13-9)
Affinity DataIC50: 4.10nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human PTK6 using poly (Glu, Tyr)4:1 as substrate in presence of [gamma33P]-ATP by HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50355504(CHEMBL1908393)
Affinity DataKd:  4.30nMAssay Description:Binding constant for BRK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50001734(CHEMBL3238103)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of Brk (unknown origin) using [gamma-33P]-ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50001735(CHEMBL3133822)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of Brk (unknown origin) using [gamma-33P]-ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM514124(US11052091, Example 3)
Affinity DataIC50: 5nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM514127(US11052091, Example 5-2)
Affinity DataIC50: 5nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50354429(CHEMBL1836846)
Affinity DataIC50: 5nMAssay Description:Inhibition of BRK pretreated for 30 mins by microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50354414(CHEMBL1836842)
Affinity DataIC50: 5nMAssay Description:Inhibition of phosphorylation of SAM68 in 293 WT-PTK6 cells after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM514138(US11052091, Example 5-21)
Affinity DataIC50: 5nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM581795(US11512087, Example 4-1)
Affinity DataIC50: 5.10nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM581830(US11512087, Example 12)
Affinity DataIC50: 5.10nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of BRK (unknown origin) preincubated for 10 mins followed by substrate addition and measured after 1 hr by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of BRK (unknown origin) preincubated for 10 mins followed by substrate addition and measured after 1 hr by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM581780(US11512087, Example 2)
Affinity DataIC50: 5.40nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50001732(CHEMBL3238097)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of Brk (unknown origin) using [gamma-33P]-ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50354420(CHEMBL1836755)
Affinity DataIC50: 6nMAssay Description:Inhibition of BRK pretreated for 30 mins by microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM514128(US11052091, Example 5-3)
Affinity DataIC50: 6nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM514129(US11052091, Example 5-4)
Affinity DataIC50: 6nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50354455(CHEMBL1836865)
Affinity DataIC50: 6nMAssay Description:Inhibition of BRK pretreated for 30 mins by microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM581829(US11512087, Example 10)
Affinity DataIC50: 6.90nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50354415(CHEMBL1836854)
Affinity DataIC50: 7nMAssay Description:Inhibition of phosphorylation of SAM68 in 293 WT-PTK6 cells after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50354455(CHEMBL1836865)
Affinity DataIC50: 7nMAssay Description:Inhibition of phosphorylation of SAM68 in 293 WT-PTK6 cells after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM514130(US11052091, Example 5-5)
Affinity DataIC50: 7nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
US Patent

TargetProtein-tyrosine kinase 6(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50354416(CHEMBL1836863)
Affinity DataIC50: 7nMAssay Description:Inhibition of phosphorylation of SAM68 in 293 WT-PTK6 cells after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
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