Compile Data Set for Download or QSAR
Report error Found 307 Enz. Inhib. hit(s) with Target = 'Tubulin alpha-1A chain'
LigandPNGBDBM762982(N-{5-[3- (cyclopropylsulfonyl)phenyl]-3- fluoropyr...)
Affinity DataIC50: 10nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM50070103((E)-1-(2',5'-Dimethoxyphenyl)-3-(4''-N,N-Dimethyla...)
Affinity DataIC50: 12nMAssay Description:Tested for inhibition of polymerization of tubulinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Rat)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM31090((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...)
Affinity DataKd:  21nMAssay Description:Binding constant for ERBB4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Rat)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4779(cid_156414 | PD0183805 | CHEMBL545315 | CHEMBL3196...)
Affinity DataKd:  29nMAssay Description:Binding constant for ERBB4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Rat)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataKd:  54nMAssay Description:Binding constant for ERBB4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Rat)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  55nMAssay Description:Binding constant for ERBB4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
LigandPNGBDBM762977(N-{5-[3- (cyclopropylsulfonyl)phenyl]-6- methylpyr...)
Affinity DataIC50: 120nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM50112256(3,4,5-Trimethoxy-benzaldehyde O-(8-hydroxy-5-methy...)
Affinity DataIC50: 170nMAssay Description:Ability to inhibit the GTP/glutamate-induced polymerization of tubulinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50012278(VINBLASTINE SULFATE | (2ALPHA,2''BETA,3BETA,4ALPHA...)
Affinity DataIC50: 200nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetTubulin alpha-1A chain(Human)TBA
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  215nMAssay Description:Binding affinity against TUBA1A (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50139772(leurocristine | 22-oxovincaleukoblastine | vincris...)
Affinity DataIC50: 220nMAssay Description:The compound was evaluated in vitro for the mammalian brain tubulin polymerization using standard assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2012
Entry Details Article

TargetTubulin alpha-1A chain(Rat)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  230nMAssay Description:Binding constant for ERBB4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50455100(CHEMBL4105066 | US12383533, Compound 63)
Affinity DataIC50: 240nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetTubulin alpha-1A chain(Rat)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM31340(CP-724714 | 2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-...)
Affinity DataKd:  260nMAssay Description:Binding constant for ERBB4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50455101(CHEMBL4217112 | US12383533, Compound 61)
Affinity DataIC50: 260nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762974(6-methyl-N-{5-[3-(oxetan-3- yl)phenyl]pyridin-2-yl...)
Affinity DataIC50: 300nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM50280140([6-(3,4,5-Trimethoxy-benzyloxy)-imidazo[1,2-b]pyri...)
Affinity DataIC50: 310nMAssay Description:In vitro mammalian brain tubulin polymerization using standard assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2012
Entry Details Article

LigandPNGBDBM762973(N-{5-[3- (cyclopropylamino)phenyl]pyridin- 2-yl}-2...)
Affinity DataIC50: 320nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM50037463(2-(3-Methoxy-phenyl)-6-morpholin-4-yl-1H-quinolin-...)
Affinity DataIC50: 363nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50037454(6-(3-Chloro-phenyl)-5H-[1,3]dioxolo[4,5-g]quinolin...)
Affinity DataIC50: 372nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50037448(6-Dimethylamino-2-(3-methoxy-phenyl)-1H-quinolin-4...)
Affinity DataIC50: 380nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Rat)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataKd:  410nMAssay Description:Binding constant for ERBB4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Human)TBA
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 430nMAssay Description:Inhibition of TUBA1A (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50037450(2-(3-Methoxy-phenyl)-6-pyrrolidin-1-yl-1H-quinolin...)
Affinity DataIC50: 437nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50409014(CHEMBL50139)
Affinity DataIC50: 447nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50106309(2-(2-fluorophenyl)-6-(pyrrolidin-1-yl)quinolin-4(1...)
Affinity DataIC50: 457nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50035218(podophyllotoxin | CHEMBL61 | Podophyllinic acid la...)
Affinity DataIC50: 460nMAssay Description:Inhibition of tubulin polymerization. (ITP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50037462(6-(3-Hydroxy-phenyl)-5H-[1,3]dioxolo[4,5-g]quinoli...)
Affinity DataIC50: 468nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Rat)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM26300(cid_16007391 | 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)a...)
Affinity DataKd:  470nMAssay Description:Binding constant for ERBB4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Rat)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd:  480nMAssay Description:Binding constant for ERBB4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
LigandPNGBDBM762970(N-[5-(3-cyclopropylphenyl)pyridin- 2-yl]pyrimidine...)
Affinity DataIC50: 480nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM50070107((E)-3-(3''-Hydroxy-4''-methoxyphenyl)-2-methyl-1-(...)
Affinity DataIC50: 500nMAssay Description:Concentration that cause a 50% inhibition in tubulin assembly as measured by an increase in turbidity using microtubule assembly assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50037457(6-(3-Fluoro-phenyl)-5H-[1,3]dioxolo[4,5-g]quinolin...)
Affinity DataIC50: 525nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50059968(2-(3-fluorophenyl)-7-methyl-1,8-naphthyridin-4(1H)...)
Affinity DataIC50: 525nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50005480(combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...)
Affinity DataIC50: 530nMAssay Description:Inhibition of tubulin polymerization (ITP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50059964(6-methyl-2-(naphthalen-1-yl)-1,8-naphthyridin-4(1H...)
Affinity DataIC50: 550nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50056948(Isonicotinic acid 1,2,3-trimethoxy-10-methylsulfan...)
Affinity DataIC50: 562nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50037444(6-(3-Methoxy-phenyl)-5H-[1,3]dioxolo[4,5-g]quinoli...)
Affinity DataIC50: 575nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50409024(CHEMBL48525)
Affinity DataIC50: 617nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50059971(2-(3-Fluoro-phenyl)-6-methyl-1H-[1,8]naphthyridin-...)
Affinity DataIC50: 631nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50009568((Thiocolchicine)N-(1,2,3-Trimethoxy-10-methylsulfa...)
Affinity DataIC50: 646nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50037459(6-(3-Methylamino-phenyl)-5H-[1,3]dioxolo[4,5-g]qui...)
Affinity DataIC50: 646nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50059966(7-Methyl-2-naphthalen-1-yl-1H-[1,8]naphthyridin-4-...)
Affinity DataIC50: 661nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50041119(2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-on...)
Affinity DataIC50: 680nMAssay Description:Inhibition of tubulin polymerization (ITP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50139772(leurocristine | 22-oxovincaleukoblastine | vincris...)
Affinity DataIC50: 680nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM50455099(CHEMBL4079324 | US12383533, Compound 27)
Affinity DataIC50: 680nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM50063845((S)-6-(3-Methoxy-phenyl)-6,7-dihydro-5H-[1,3]dioxo...)
Affinity DataIC50: 692nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50009568((Thiocolchicine)N-(1,2,3-Trimethoxy-10-methylsulfa...)
Affinity DataKi:  700nMAssay Description:Compound was evaluated for its ability to inhibit the binding of [3H]-colchicine to tubulin in competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50409011(CHEMBL45711)
Affinity DataIC50: 724nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50037453(6-(3-Amino-phenyl)-5H-[1,3]dioxolo[4,5-g]quinolin-...)
Affinity DataIC50: 724nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
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