Target (15)
Compound (770)
Article Title (7)
Assay (203)
BDBM50324962 3-(2-Bromophenyl)-6-methylcoumarin CHEMBL1221929
CHEMBL12626 6-Hydroxy-4-methyl-chromen-2-one BDBM50078830 6-hydroxy-4-methylcoumarin
3,4-Benzo-7-acetonyloxy-8-methylcoumarin BDBM50246269 CHEMBL488072
7-Acetonyloxy-3,4-cyclohexene-8-methylcoumarin BDBM50246265 CHEMBL488073
7-Acetonyloxy-3,4-cyclopentene-8-methylcoumarin CHEMBL488076 BDBM50246264
BDBM23735 benzyloxycarbonyl-Phe-Arg-7-amino-4-methylcoumarin
Ub-AMC ubiquitin-7-amido-4-methylcoumarin BDBM23422
3,4-Benzo-7-(beta-bromoallyloxy)-8-methylcoumarin CHEMBL487235 BDBM50246306
BDBM23733 benzoyl-Phe-Val-Arg-7-amino-4-methylcoumarin
BDBM23734 benzyloxycarbonyl-Gly-Gly-Arg-7-amino-4-methylcoumarin
CHEMBL488074 7-(beta-Bromoallyloxy)-3,4-cyclopentene-8-methylcoumarin BDBM50246267
CHEMBL488075 7-(beta-Bromoallyloxy)-3,4-cyclohexene-8-methylcoumarin BDBM50246268
Suc-Ala-Ala-Pro-Phe-7-amino-4-methylcoumarin BDBM23729
BDBM31994 Z-Arg-Arg-AMC Benzyloxycarbonylarginyl-arginine 4-methylcoumarin-7-ylamide
Boc-Gly-Arg-Arg-AMC BDBM33263 AMC, 7-amido-4-methylcoumarin
N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methylcoumarin BDBM23699
CBZ-Phe-Arg 7-amido-4-methylcoumarin Z-Phe-Arg-AMC BDBM22047
BDBM20128 Z-Phe-Arg-NHMec Z-Phe-Arg-NH-4-methylcoumarin-7-yl
Suc-LY-AMC (AMC=7-Amino-4-methylcoumarin) BDBM23856 Suc-Leu-Tyr-AMC
Z-Leu-Arg-NH-4-methylcoumarin-7-yl BDBM20130 Z-Leu-Arg-NHMec
BDBM246526 Z-Arg-Leu-Arg-Gly-Gly-7-amido-4-methylcoumarin Z-RLRGG-AMC
BDBM20129 Z-Val-Val-Arg-NH-4-methylcoumarin-7-yl Z-Val-Val-Arg-NHMec
BDBM33248 Bz-nKRR-AMC benzoyl-Nle-Lys-Arg-Arg-7-amido-4-methylcoumarin Bz-Nle-Lys-Arg-Arg-AMC
Met-AMC (2S)-2-amino-N-(4-methyl-2-oxo-2H-chromen-7-yl)-4-(methylsulfanyl)butanamide L-methionine-7-amido-4-methylcoumarin BDBM17353
BOC-Val-Pro-Arg-7-amido-4-methylcoumarin Thrombin Fluorogenic Substrate BOC-Val-Pro-Arg-MCA tertiary-butyloxycarbonyl-valyl-prolyl-arginyl-7-amino-4-methylcoumarin BDBM12583 tert-butyl N-[(2S)-1-[(2S)-2-{[(2S)-5-carbamimidamido-2-[(4-methyl-2-oxo-2H-chromen-7-yl)amino]pentanamido]carbonyl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
7,8-Dihydroxy-4-methyl-2H-chromen-2-one (3) CHEMBL276618 7,8-dihydroxy-4-methylcoumarin 7,8-dihydroxy-4-methyl-2H-chromen-2-one 7,8-Dihydroxy-4-methyl-chromen-2-one BDBM50022184
uPA Substrate 4-{[({4-carbamimidamido-1-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]butyl}carbamoyl)methyl]carbamoyl}butanoic acid hydrochloride Glutaryl-Gly-Arg-7-amido-4-methylcoumarin BDBM14484
Gly-Pro-7-amido-4-methylcoumarin hydrobromide Gly-Pro-7-amidomethylcoumarin BDBM11057 Gly-Pro-AMC 1-(2-aminoacetyl)-N-(4-methyl-2-oxo-2H-chromen-7-yl)pyrrolidine-2-carboxamide hydrobromide
US12358931, Example 6-6 BDBM277587 US10947254, Example 6-6 US11780852, Example 6-6 US10072026, Example 6-6
US9663506, Example 6-6 BDBM213059 US9278960, 6-6
US9487511, 6 US10414761, Example 6 BDBM256627 US9920047, 6 US10053456, 6 US10968213, Example 6 US9718814, 6
US9796723, 6 BDBM200578 US10590139, Example 6 US9227975, 6 US10011604, 6
BDBM136589 US11267818, Example 6 US10005783, 6 BDBM227973 US10774085, Example 6 US8865698, 6 US9676783, 6
US9024044, 6 BDBM158078 US9227949, 6 US9655879, 6
US9388176, 6 US8889870, 6 BDBM139546 US9820989, 6
US9540388, 6 US10053462, 6 BDBM174775 US9102686, 6
BDBM202661 US9694016, 6 US10245267, Example 6 US10709712, Example 6 US9242969, 6
BDBM239011 US9597317, 6 US10478423, Cpd. 6 US10028934, Compound 6 US9408850, 6
US10487086, Example 6 US8940720, 6 BDBM142858 US9802939, 6 US11136327, Example 6
BDBM161221 US10087143, Compound 6 US9051270, 6 US10738009, Compound 6 US9758483, Compound 6 US11673864, Compound 6
US10604504, Example 6 US9920031, Example 6 US9802915, Example 6 US9688629, 6 BDBM164812 US11623921, Example 6
US9586962, Example 6 BDBM118353 US11667644, Example 6 USRE48841, Example 6 US11059828, Example 6 US8653263, 6
US9796724, Example 6 US8791123, 6 BDBM127633 US10251889, Example 6 US10758542, Example 6 US9782415, Example 6
US10836768, Cpd no 6 US9987274, Compound 6 BDBM242743 US20240199618, Compound 6 US9422299, 6 US11731974, Compound 6 US10030025, Compound 6
US10913740, Example 6 US10183942, Example 6 BDBM292109 US10100049, Example 6 US11299492, Example 6 US11718616, Example 6 US10526330, Example 6
BDBM147500 US8962608, 6-6
BDBM211221 US9247759, 6-6
US8742110, 6-6 BDBM123288
US9328099, 6-6 BDBM228960
US9394282, 6-6 BDBM237819
US9688645, 6-6 BDBM173932
US10045974, 6 US9346797, 6 US10603310, Compound 6 BDBM230870
US10238633, Example 6 US8987249, 6 BDBM150332 US9713606, 6
US10640503, Example 6 BDBM103892 US10047086, 6 US9695168, 6
US9227969, 6 BDBM200378 US9629836, 6 US10011599, Example 6
US9708313, 6 BDBM190895 US9181249, 6 US10077266, Example 6
US9949975, Example 6 US8981112, 6 US9526727, 6 BDBM150699
BDBM135621 US9458201, 6 US8846601, 6 US10632171, Peptide No. 6 US10179804, Example 6
BDBM259407 US11673868, Example 6 US11180460, Example 6 US10457647, Example 6 US9512084, 6
CHEMBL383344 (E)-6'-chloro-6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine BDBM50182453
US10034939, Example 6 US9320732, 6 BDBM223004 US10967060, Example 6 US11207302, Example 6
US10213433, Compound 6 US20240043404, Example 6 US9174982, 6 US11369599, Compound 6 BDBM189460
US10385066, Example 6 US10174049, Example 6 US9796729, 6 US9738658, Example 6 BDBM321139
US10544126, Example 6 US9475795, 6 US10167273, Example 6 BDBM250527 US11512066, Example 6
US10568884, Cpd 6 US9314464, 6 BDBM221685 US9593100, Compound 6 USRE49556, Compound 6
US10941151, Compound 6 US10065961, Compound 6 US9475814, 6 BDBM251908 US10683295, Compound 6
US9464084, 6 BDBM254132 US10703749, Example 6 US10112937, Example 6 US10150765, Example 6
BDBM352202 US10239868, Entry 6 US20240425487, Entry 6 US9802924, Entry 6 US10676464, Entry 6 US10287274, Entry 6
BDBM465217 US11560376, Compound 6 US10793564, Compound 6 US11419869, Compound 6 US20230271960, Compound 6 US20230293519, Compound 6
US10144734, Example 6 US10441581, Example 6 US10881652, Example 6 BDBM304990 US10172845, Example 6 US11648243, Example 6
US10343992, Example 6 US11053198, Example 6 US10689345, Example 6 US11390584, Example 6 BDBM404347 US11066365, Example 6
US10544128, Compound 6 US10106527, Compound 6 BDBM293420 US11548872, Compound 6 US9951048, Compound 6 US20230286945, Compound 6
US10689414, Compound 6 US11667673, Compound 6 BDBM363513 US10640534, Compound 6 US11021515, Compound 6 US9850277, Compound 6
US10781209, Example 6 US11702416, Example 6 US10472358, Example 6 BDBM391506 US11059821, Example 6 US9957268, Example 6
US11117874, Example 6 US11680049, Example 6 CHEMBL3945475 US20230278969, Example 6 US10287258, Example 6 US10669245, Example 6 US11655221, Example 6 BDBM50195255
US8816088, I-6 US9572802, Compound I-6 US9682957, I-6 US9394275, I-6 BDBM103742 US8551978, I-6
BDBM176823 US10391089, Compound 6 US9675614, 6 US10307413, Compound 6 US10980794, Cmpd No 6
BDBM385045 US11174244, Compound 6 US10287267, Compound 6 US10508099, Compound 6 US11673881, Compound 6
US10875867, Example 6 US11691977, Example 6 BDBM284715 US10023575, Example 6 US10479794, Example 6
US11161855, Example 6 US9908895, Example 6 US10370387, Example 6 US9777017, Example 6 BDBM344022
US11591316, Compound 6 BDBM384296 US9932325, Example 6 US10590114, No. 6 US11111235, No. 6
US11725004, Example 6 US11084810, Example 6 BDBM295698 US10112934, Example 6 US10570125, Example 6
US9775844, Compound 6 BDBM340014 US11541059, Compound 6 US10329299, Compound 6 US10675286, Compound 6
US9975907, Example 6 US10829502, Example 6 BDBM394287 US11401280, Example 6 US10428087, Example 6
BDBM140280 US10947243, Example 6 US9914735, Example 6 US8912173, 6
BDBM155360 US10383871, Example 6 US9006269, 6 US10918640, Example 6
BDBM185190 US9156829, 6 US10689373, Example 6 US10011588, Example 6
BDBM247483 US9434719, 6 US9688672, Example 6 US10112931, Example 6
BDBM250096 US10501411, Example 6 US11697648, Example 6 US9452980, 6
BDBM265032 US9718793, 6 US11234987, Example 6 US10413550, Example 6
BDBM283812 US10023562, Example 6 US10544133, Example 6 US9657009, 6
US10155002, Compound 6 US11052093, Compound 6 BDBM172002 US9090562, 6
US10513499, Compound 6 US11254644, Compound 6 BDBM261535 US9708272, 6
US11236095, Example 6 US9492453, 6 BDBM256830 US10654855, Example 6
US8551988, 6 BDBM103536 US10201527, Compound 6 US10736881, Compound 6
US8877795, 6 US10278929, Compound 6 BDBM138357 US11337935, Compound 6
US9079866, 6 BDBM168633 US9884878, Compound 6 US9745328, Compound 6
US9260440, 6 US9617273, Example 6 US10501467, Example 6 BDBM207561
US9487512, 6 BDBM256461 US9944601, Example 6 US10329256, Example 6
US9662330, Compound 6 BDBM224329 US9321760, 6 US10080750, Compound 6
US9822102, Example 6 BDBM246101 US10183932, Example 6 US9434690, 6
US9920060, 6 BDBM376912 US11696917, Example 6 US10329300, Example 6
USRE47636, Example 6 BDBM201017 US9540373, 6 US9879026, Example 6
US10765676, Example 15-6 US9463192, 15-6 US10300060, Example 15-6 US9993479, 15-6 BDBM249327 US9763943, 15-6
US9763943, 14-6 US9463192, 14-6 US10765676, Example 14-6 BDBM249324 US10300060, Example 14-6 US9993479, 14-6
BASTADIN 6 BDBM50428739 Bastadin-6
BDBM108097 US8598206, Table 6, 6
BDBM110238 US9206232, 6 US8613914, 6
BDBM113578 US8633196, 6 US9365529, 6
BDBM138495 US8877775, 6 US9073869, 6
BDBM144825 US8952157, 6 US9303025, 6
BDBM156383 US9248140, 6 US9018381, 6
BDBM160065 US9040534, 6 US10047092, 6
BDBM160592 US9045468, 6(-) US9045468, 6(+)
BDBM175104 US9611251, 6 US9115117, 6
BDBM177582 US9120769, 6 US9663470, 6
BDBM185596 US9493431, 6 US9156856, 6
BDBM209585 US10016420, 6 US9273011, 6
BDBM221522 US9303045, 6 US9695195, 6
BDBM235183 US9365558, 6 US9822074, 6
BDBM300754 US10130642, Example 6-6
BDBM36603 4'',6''-Dideoxybalanol, 6
BDBM392008 US10301272, Example 6/6
BDBM609416 US11702418, Example 6-6
BDBM9224 US8815901, 6 US8536175, 6
US10004738, 6 US9353084, 6 BDBM234453
US11053242, Compound 6-6 BDBM516515
US20240383922, Example 6-6 BDBM706655
US8614234, 6 BDBM110538 US9725433, 6
US8921370, 6 US9656975, 6 BDBM141502
US8969586, 6 BDBM144616 US9598436, 6
US9040714, 6 BDBM160339 US9693992, 6
US9169243, 6 BDBM187358 US9908875, 6
US9211296, Table 6, 6 BDBM196152
US9221791, 6 BDBM198660 US9556143, 6
US9266895, 6 US8940744, 6 BDBM143181
US9290459, 6 US9670166, 6 BDBM211690
US9409895, 6 BDBM241095 US9630945, 6
US9427428, 6 BDBM243440 US9433609, 6
US9475775, 6 BDBM254739 US9597333, 6
US9475809, 6 BDBM251894 US9918969, 6
US9499542, 6 BDBM254923 US9675594, 6
US9682971, 6 BDBM164973 US9067917, 6
US9688695, 6 US10047103, 6 BDBM175973
US9695170 6 BDBM141550 US8921389, 6
US9714242, 6 US8772511, 6 BDBM125049
US9732066, 6 US9216968, 6 BDBM197407
US9751856, 6 US9682959, 6 BDBM143699
Ex. 6/KM-06-80/(I-6) US10683309, Example 6 BDBM445668 US11028104, Example 6
US11197867, Example 6 BDBM329923 US10980815, Ex. No. 6 US10463675, Example 6 US9663526, Example 6
BDBM292151 US11046702, Example 6 US10100057, Example 6 US9745310, Example 6
BDBM303822 US11130754, Example 6 US10138241, Example 6 US12139484, Example 6
BDBM311569 Ex. Cpd. 6 US11046696, Compound 6 US10807986, Example 6
BDBM314693 US11214573, Example 6 US10513522, Example 6 US9611269, Example 6
BDBM331869 US10189849, Compound 6 US10927120, Compound 6 US9957276, Compound 6
BDBM377338 US10676434, Example 6 US11053197, Example 6 US10266491, Example 6
BDBM427051 US11236047, Example 6 US10544132, Example 6 US10981898, Example 6
BDBM458532 US10745401, Example 6 US12180213, Example 6 US11466007, Example 6
US10329273, Example 6 BDBM38192 US10093650, Example 6 US11479538, Example 6
US10329302, Example 6 US10793579, Example 6 BDBM402783 US11702424, Example 6
US10442803, Example 6 BDBM343407 US11091484, Example 6 US9777003, Example 6
US10604535, Example 6 BDBM356236 US9896458, No. 6 US9815850, Compound 6
US10759805, Ex 6 BDBM272540 US10065967, Example 6 US9745307, Example 6
US10836763, Example 6 US11713315, Example 6 BDBM472924 US10844057, Example 6
US10995088, Example 6 BDBM469063 US10807974, Example 6 US11608330, Example 6
US11111242, Example 6 US20250134869, Example 6 US9617258, Example 6 BDBM316518
US11117902, Example 6 US10654866, Example 6 BDBM443439 US11634426, Example 6
US11634410, Example 6 BDBM319587 US10988463, Example 6 US10174007, Example 6
US20250017938, Compound 002-6 US9428502, 6 BDBM244397 US10226449, cpd 6
US20250282790, Entry 6 US11319327, Entry 6 BDBM474386 US10858368, Entry 6
US9586949, Example 6 BDBM281481 US10596184, Example 6 US10022387, Example 6
US9605007, Comparator 6 BDBM223413 US9744173, Comparator 6 US9315520, Comparator 6
US9938289, 6 BDBM172454 US9260450, 6 US20240307363, Compound 5 US9090625, 6
N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- cyanoquinolin-6-yl)methyl)isonicotinamide US11021463, Example 6 US9611252, Example 6 US10266515, Example 6 US10023557, Example 6 BDBM283354 US10308637, Example 6
BDBM50114819 6-Oxo-6-phenyl-hexanoic acid hydroxyamide CHEMBL95152 N-hydroxy-6-oxo-6-phenylhexanamide
US10875864, EX. 8-6 BDBM242350 US10047093, 8-6 US10392392, Example 8-6 US9416132, 8-6
BASTADIN 6 CHEMBL505907 bastadin-6 BDBM50241984
BDBM159753 US9035074, 6 US10966980, Example 6
BDBM162315 US10307427, Compound 6 US9051313, 6
BDBM177791 US9120791, Example 6 US9603854, 6
BDBM181163 US9139529, 6 US9783501, Compound 6
BDBM185798 US9163003, 6 USRE46942, Example 6
BDBM215055 US9296736, 6 US9593129, Example 6
BDBM244803 US9738649, Example 6 US9422293, 6
BDBM251670 US9464060, 6 US10100018, Example 6
BDBM259329 US9505745, 6 US9790212, Example 6
BDBM323598 US9789110, 6 US10188653, Example 6
BDBM50384798 US9757369, 6 CHEMBL2037482 US9585879, 6
CHEMBL3585679 BDBM50093523 PTP1B spring 6 (6)
US10195181, Example 6 US9403810, 6 BDBM239105
US10369153, Compound 6 US9346810, 6 BDBM228764
US10507215, Compound 6 US9000015, 6 BDBM153689
US10556908, Example 6 US9695180, 6 BDBM111154
US10633384, Example 6 BDBM258521 US9493486, 6
US10745364, Example 6 US9809561, 6 BDBM352496
US10947226, Example 6 Method #6 BDBM486459
US11547697, Compound 6 BDBM118954 US9682141, 6
US8697868, 1(6) US8697868, 6 BDBM120068
US8952169, 6 US9771376, Example 6 BDBM145227
US9073876, 6 BDBM166920 US9732093, Compound 6
US9073922, 6 US9796708, Example 6 BDBM167522
US9107923, 6 BDBM160917 US11014909, Example 6
US9120786, 6 US10000475, Compound 6 BDBM177777
US9127027, 6 CHEMBL3322800 US9422318, 6 BDBM50057423
US9163008, 6 BDBM185917 US9656968, Compound 6
US9212139, 6 BDBM196448 US10202344, Compound 6
US9212153, 6 BDBM195423 US10336717, Compound 6
US9216999, 6 BDBM198198 US9556187, Example 6
US9221828, 6 BDBM50443634 CHEMBL3092462 US9174993, 6
US9278944, 6 US10155731, Example 6 BDBM212462
US9284322, Table 6, Compound 6 BDBM221040
US9320722, 6 CB29 (derivative 6) BDBM109216
US9334286, 6 BDBM229978 US10188642, Example 6
US9340537, 6 BDBM230752 US9896444, Example 6
US9345793, 6 US9744252, Example 6 BDBM228625
US9346815, 6 BDBM232460 US9604984, Example 6
US9493448, 6 BDBM258104 US9845313, Example 6
US9532990, 6 US10300066, Compound 6 BDBM260532
US9540323, 6 BDBM260820 US9540323, example 6
US9611222, Example 6 US9056832, 6 BDBM162387
US9650366, 6 BDBM308056 US10011593, Ex. 6
US9650377, Example 6 US8853203, 6 BDBM135952
US9657007, Example 6 US9512114, 6 BDBM259447
US9682965, 6 US10023561, Example 6 BDBM148449
US9682966, 6 BDBM154336 US10118915, Compound 6
US9682983, 6 US10017516, Compound 6 BDBM127883
US9738632, Example 6 BDBM141372 US8916600, 6
US9738668, Compound 6 BDBM232925 US9346839, 6
US9902710, Compound 6 BDBM194324 US9200016, 6
US9951071, Example 6 US9409908, 6 BDBM241374
9-[6',6'-Difluoro-6'-(diethylphosphono)hexyl]-9-deazaguanine CHEMBL600664 BDBM50308521
BDBM213062 US9278960, 6-11 US9278960, 6-9 US9663506, Example 6-11
US10253015, Compound I-6 6-{[(1S)-1-(6-chloro-2- BDBM375146
US10377744, Compound No. 6 BDBM408985 US11123311, Compound 6 US11723929, Compound 6
US9718822, 6 BDBM267410 US9750744, Example 6 US9718822, 4 US9902741, Example 6
6-Amino-6-deoxy-beta-cyclodextrin (am-beta-CD) 6-NH2-beta-cyclodextrin BDBM36127 mono(6-amino-6-deoxy)-beta-cyclodextrin
US10072026, Example 6-32 US10947254, Example 6-32 US12358931, Example 6-32 US10072026, Example 6-47 BDBM277613 US11780852, Example 6-32
US10947254, Example 6-46 US12358931, Example 6-46 US10072026, Example 6-49 BDBM277627 US11780852, Example 6-46 US10072026, Example 6-46
cid_613677 6-[(4-methylphenyl)sulfonyl]-6-azabicyclo[3.2.1]octane 6-tosyl-6-azabicyclo[3.2.1]octane 6-(4-methylphenyl)sulfonyl-6-azabicyclo[3.2.1]octane MLS000850649 SMR000456666 BDBM46984
US10179769, Example 6 3-{[4-hydroxymethyl)benzyl]amino}pyridine-4-carboxylic acid US9725441, Example 6 US11214542, Example 6 US9611221, Example 6 BDBM314102 US10807956, Example 6 US11639333, Example 6 US9828343, Example 6
US10548896, Example 6 US10328077, Example 6 US9573930, Example 6 US11084793, Example 6 4-[2-(4-amino-piperidin-1-yl)-5- (4-methoxyphenyl)-1-methyl-6-oxo- 1,6-dihydro-pyrimidin-4-yl]- 2-fluorobenzonitrile US9776974, Example 6 US10207999, Example 6 US10849898, Example 6 US10960005, Example 6 US10023543, Example 6 US9771329, Example 6 BDBM283215
US11261191, Example 6 US10738052, Example 6 6-(1-(6-(4-Fluorophenyl)imidazo[1,2-a]pyrimidin-3-yl)cyclopropyl)quinoline US9944645, 6 BDBM388652
BDBM277584 US10947254, Example 6-3 US12358931, Example 6-3 US11780852, Example 6-3 US10072026, Example 6-3
BDBM277585 US10947254, Example 6-4 US12358931, Example 6-4 US11780852, Example 6-4 US10072026, Example 6-4
BDBM277595 US10947254, Example 6-14 US11780852, Example 6-14 US12358931, Example 6-14 US10072026, Example 6-14
BDBM277596 US10947254, Example 6-15 US11780852, Example 6-15 US12358931, Example 6-15 US10072026, Example 6-15
BDBM277631 US10072026, Example 6-50 US10947254, Example 6-50 US11780852, Example 6-50 US12358931, Example 6-50
BDBM277640 US10947254, Example 6-59 US11780852, Example 6-59 US12358931, Example 6-59 US10072026, Example 6-59
BDBM277641 US11780852, Example 6-60 US10072026, Example 6-60 US10947254, Example 6-60 US12358931, Example 6-60
US10072026, Example 6-10 BDBM277591 US10947254, Example 6-10 US12358931, Example 6-10 US11780852, Example 6-10
US10072026, Example 6-11 BDBM277592 US10947254, Example 6-11 US12358931, Example 6-11 US11780852, Example 6-11
US10072026, Example 6-20 US10947254, Example 6-20 US11780852, Example 6-20 US12358931, Example 6-20 BDBM277601
US10072026, Example 6-21 US10947254, Example 6-21 US12358931, Example 6-21 BDBM277602 US11780852, Example 6-21
US10072026, Example 6-22 US10947254, Example 6-22 US12358931, Example 6-22 BDBM277603 US11780852, Example 6-22
US10072026, Example 6-30 US10947254, Example 6-30 US11780852, Example 6-30 US12358931, Example 6-30 BDBM277611
US10072026, Example 6-31 US10947254, Example 6-31 US11780852, Example 6-31 US12358931, Example 6-31 BDBM277612
US10072026, Example 6-33 US10947254, Example 6-33 US12358931, Example 6-33 BDBM277614 US11780852, Example 6-33
US10072026, Example 6-40 US10947254, Example 6-40 US11780852, Example 6-40 US12358931, Example 6-40 BDBM277621
US10072026, Example 6-43 US10947254, Example 6-43 US12358931, Example 6-43 BDBM277624 US11780852, Example 6-43
US10072026, Example 6-44 US10947254, Example 6-44 US12358931, Example 6-44 BDBM277625 US11780852, Example 6-44
US10072026, Example 6-51 US10947254, Example 6-51 US11780852, Example 6-51 US12358931, Example 6-51 BDBM277632
US10072026, Example 6-52 US10947254, Example 6-52 US11780852, Example 6-52 US12358931, Example 6-52 BDBM277633
US10072026, Example 6-54 US10947254, Example 6-54 US12358931, Example 6-54 BDBM277635 US11780852, Example 6-54
US10072026, Example 6-55 US10947254, Example 6-55 US12358931, Example 6-55 BDBM277636 US11780852, Example 6-55
US10072026, Example 6-7 US10947254, Example 6-7 US12358931, Example 6-7 US11780852, Example 6-7 BDBM277588
US10072026, Example 6-9 US10947254, Example 6-9 US11780852, Example 6-9 BDBM277590 US12358931, Example 6-9
US10947254, Example 4-6 US12358931, Example 4-6 BDBM277515 US11780852, Example 4-6 US10072026, Example 4-6
US10947254, Example 6-12 US12358931, Example 6-12 BDBM277593 US11780852, Example 6-12 US10072026, Example 6-12
US10947254, Example 6-13 US12358931, Example 6-13 BDBM277594 US11780852, Example 6-13 US10072026, Example 6-13
US10947254, Example 6-23 US12358931, Example 6-23 BDBM277604 US11780852, Example 6-23 US10072026, Example 6-23
US10947254, Example 6-26 US11780852, Example 6-26 US12358931, Example 6-26 BDBM277607 US10072026, Example 6-26
US10947254, Example 6-34 US12358931, Example 6-34 BDBM277615 US11780852, Example 6-34 US10072026, Example 6-34
US10947254, Example 6-35 US12358931, Example 6-35 BDBM277616 US11780852, Example 6-35 US10072026, Example 6-35
US10947254, Example 6-36 US11780852, Example 6-36 US12358931, Example 6-36 BDBM277617 US10072026, Example 6-36
US10947254, Example 6-45 US12358931, Example 6-45 BDBM277626 US11780852, Example 6-45 US10072026, Example 6-45
US10947254, Example 6-56 US12358931, Example 6-56 BDBM277637 US11780852, Example 6-56 US10072026, Example 6-56
US10947254, Example 6-57 US12358931, Example 6-58 BDBM277639 US10072026, Example 6-58 US11780852, Example 6-57
US10947254, Example 6-58 US11780852, Example 6-58 US12358931, Example 6-57 BDBM277638 US10072026, Example 6-57
US11377428, Compound I-6 US11370764, Compound I-6 BDBM470229 US11332451, Compound I-6 US10815206, Compound I-6
US11780852, Example 6-16 US12358931, Example 6-16 BDBM277597 US10072026, Example 6-16 US10947254, Example 6-16
US11780852, Example 6-17 US12358931, Example 6-17 BDBM277598 US10072026, Example 6-17 US10947254, Example 6-17
US11780852, Example 6-18 US10072026, Example 6-18 BDBM277599 US10947254, Example 6-18 US12358931, Example 6-18
US11780852, Example 6-19 US10072026, Example 6-19 BDBM277600 US10947254, Example 6-19 US12358931, Example 6-19
US11780852, Example 6-28 US12358931, Example 6-28 BDBM277609 US10072026, Example 6-28 US10947254, Example 6-28
US11780852, Example 6-29 US10072026, Example 6-29 BDBM277610 US10947254, Example 6-29 US12358931, Example 6-29
US11780852, Example 6-39 US12358931, Example 6-39 BDBM277620 US10072026, Example 6-39 US10947254, Example 6-39
US12358931, Example 1-6 US10072026, Example 1-6 US10947254, Example 1-6 US11780852, Example 1-6 BDBM277412
US12358931, Example 5-6 US10947254, Example 5-6 US11780852, Example 5-6 BDBM277544 US10072026, Example 5-6
US12358931, Example 6-1 BDBM277582 US10072026, Example 6-1 US10947254, Example 6-1 US11780852, Example 6-1
US12358931, Example 6-5 BDBM277586 US10947254, Example 6-5 US11780852, Example 6-5 US10072026, Example 6-5
2,3-dinor-6-ketoprostaglandin F1alpha CAS_64700-71-6 BDBM82096 PGF1alpha, 6-oxo
6-Cl-purine (1) CHEMBL226396 6-chloroguanine BDBM50208877 2-amino-6-chloropurine
BDBM32026 BDBM32208 cid_11373 SMR000036663 quinolin-6-amine 6-quinolinamine 6-quinolylamine MLS000080747
US10106559, Example 6 US9850258, Example 6 US10435415, Example 6 BDBM230084 US9334290, 5
US10434101, Compound I-6 US11096942, Compound I-6 US8975249, I-6 BDBM149406
US11071721, Example 37 Method #6 BDBM508761 US11071721, Example 6 US11607396, Example 6
US11077107, Example III-6 US9266891, III-6 US10328074, Example III-6 BDBM209465
US20240109913, Example I-6 US10919913, # I-6 BDBM374735 US10246467, Example I-6
6-2 US20250221987, Example 6-1 BDBM757036
BDBM209922 6'-Guanidinonaltrindole (6'-GNTI)
BDBM232953 US9862721, 6(53) US9353113, 6(53)
BDBM243262 US10196387, Example 6 US10053454, Example 6
BDBM261483 US10011568, Ex. No. 6 US9708266, 6
BDBM271190 US10975091, Example 6 US10059720, Example 6
BDBM275064 US9879032, Example 6 US10221195, Example 6
BDBM311870 US10166214, Example 6 US10675268, Example 6
BDBM329650 US11001583, Compound 6 US9663515, Compound 6
BDBM336960 US9745291, Compound 6 US9765068, Compound 6
BDBM364324 US9856274, Compound 6 US10570156, Compound 6
BDBM373058 US9896435, Example 6 US10851080, Example 6
BDBM382175 US10584135, Example 6 US10273244, Example 6
BDBM412790 US10399989, Example 6 US10611766, Example 6
BDBM412889 US10399991, Example 6 US10822345, Ex 6
BDBM414588 US10435405, Example 6 US10934288, Example 6
BDBM416540 US10632122, Example 6 US10307425, Example 6
BDBM420343 US10479788, Example 6 US11046688, Example 6
BDBM448533 US10696655, Example 6 US11168070, Example 6
BDBM456287 US10723742, Example 6 US11510915, Example 6
BDBM459497 US10772893, Example 6 US11529356, Example 6
BDBM460892 US11352329, COMPD # 6 US10774053, Compound 6
BDBM461299 US11427560, Example 6 US10774068, Example 6
BDBM466550 US10800755, Example 6 US11014905, Example 6
BDBM498966 US11542265, Example 6 US11014929, Example 6
BDBM500325 US11655249, Example 6 US11021478, Example 6
BDBM50478829 CHEMBL478727 6-(6-Methoxynaphthalyl)Triazolylhexahydroxamic Acid
BDBM532503 US11214557, Example 6 US11332453, Example 6
BDBM537692 US11248001, Example 6 US11603523, Example 6
BDBM549562 US11306075, Ex. 6 US20240158379, Example 6
BDBM557345 US11352361, Example 6 US11680068, Example 6
BDBM557415 US11352363, Example 6 US11384090, Compound 6
BDBM561462 US11390631, Example 6 US12268694, Example 6
BDBM573233 US11453683, Example 6 US20230279025, Example 6
BDBM581323 US11504381, Compound 6 US11548866, Compound 6
BDBM600678 US11629146, Compound 6 US20250163068, Compound 6
BDBM624984 US20230322747, Compound 6 US20250250263, Compound 6
BDBM699167 US20240327430, Example 6 US12145945, Example 6
BDBM764569 US20250257055, Example 6 US20250263415, Example 6
BDBM82509 melatonin, 6-Hydroxy Melatonin,6-Hydroxy
CHEMBL2322239 BDBM50427454 US10308662, Compound 6 US9505780, 6
US10072001, Example 6 BDBM276820 US10259811, Example 6
US10202365, Compound 6 BDBM345829 US10774070, Compound 6
US10259818, Example 6 US9944646, Example 6 BDBM377024
US10272077, Example 6 BDBM362172 US9833448, Example 6
US10287278, Example 6 US10647706, Example 6 BDBM385544
US10344025, Example 6 BDBM404667 US11370786, Example 6
US10421747, Compound 6 BDBM373523 US9902714, Compound 6
US10478424, Example 6 BDBM273232 US10071079, Example 6
US10550089, Example 6 BDBM429530 US10995072, Example 6
US10556902, No 6 US11612599, Compound 6 BDBM430396
US10562916, Compound 6 BDBM362433 US9834564, Compound 6
US10669235, Example 6 US11208381, Example 6 BDBM445215
US10676431, Example 6 US11117861, Example 6 BDBM450241
US10710980, Example 6 US10947218, Example 6 BDBM451774
US10781211, Example 6 US10030020, Example 6 BDBM280461
US10869929, Compound 6 US11554172, Compound 6 BDBM476572
US10934297, Compound 6 BDBM484612 US11713320, Compound 6
US10947215, Example 6 BDBM298600 US10125118, Example 6
US10947252, Example 6 BDBM486575 US11427601, Example 6
US10995073, Example 6 US10508086, Example 6 BDBM421415
US10995089, Example 6 BDBM495171 US11708364, Example 6
US11008308, Example 6 BDBM434084 US10562891, Example 6
US11028092, Example 6 US10934294, Example 6 BDBM484484
US11168090, Example 6 US11851434, Example 6 BDBM524564
US11242343, Example 6 BDBM536099 US11891388, Example 6
US11312711, Example 6 US10508107, Example 6 BDBM422800
US11390625, Example 6 US11390625, Compound 6 BDBM561439
US11414404, Ex. # 6 US11634409, Example 6 BDBM565129
US11530237, Compound 6 BDBM585850 US11542297, Compound 6
US11555029, No. 6 BDBM451867 US10710986, Example 6
US11584714, Compound 6# US12195427, Compound 6# BDBM594026
US11608309, Compound 6 US9187406, Compound 6 BDBM191769
US11673886, Example 6 US11078197, Example 6 BDBM510829
US12410173, Compound 6 BDBM635491 US11814388, Compound 6
US20130102619, 6 BDBM97375 Orexin receptor antagonist 6
US20230279023, Compound 6 US11459335, Compound 6 BDBM575209
US20230280220, Example 6 BDBM604257 US11661419, Example 6
US20230322789, Compound 6 BDBM625408 US20230322789, Example 6
US20240010658, Example 6 BDBM645025 US11981682, Example 6
US20240101536, Example 6 US10889571, Example 6 BDBM477665
US20240277683, Example 6 BDBM653585 US11911372, Example 6
US20240300954, Entry 6 BDBM489595 US10961249, Entry 6
US20250017938, Compound 001-6 BDBM136955 US8871790, 6
US20250186410, Compound 6 BDBM477111 US10888567, Compound 6
US20250215017, Compound 6 US20250179094, Compound 6 BDBM747267
US8614253, 36-6 US9241942, 36-6 BDBM111392
US9138393, 6-Chloropurine BDBM181123 US9144538, 6-Chloropurine
US9241942, 26-6 BDBM111219 US8614253, 26-6
US9241942, 27-6 BDBM111246 US8614253, 43-6
US9241942, 28-6 US8614253, 28-6 BDBM111330
US9241942, 38-6 US8614253, 38-6 BDBM111405
US9247759, 6-18 BDBM211222 US9247759, 6-7
US9247759, 6-20 BDBM211223 US9247759, 6-9
US9278960, 5-6 US9636337, 5-6 BDBM213054
US9278960, 6-5 BDBM213058 US9636337, 6-5
US9353113, 6(65) BDBM232955 US9862721, 6(65)
US9624246, Compound 6 US10517872, Compound 6 BDBM318829
US9790229, Compound 6 US10577374, Compound 6 BDBM348283
US9862721, 6(63) BDBM232954 US9353113, 6(63)
US9938267, Cmpd ID 6 BDBM108449 US8604016, 6
US9969726, Example 6 US10597367, Example 6 BDBM393684
US9981925, Compound 6 BDBM369716 US10233160, Compound 6
US9994590, Compound 6 US10604536, Compound 6 BDBM397934
aminopyridine-pyrrolidine, 6 CHEMBL481815 US9090589, 6 BDBM29234
BDBM50261992 6-(6-(7-phenylheptanoyl)pyridazin-3-yl)picolinonitrile CHEMBL467182 6-(6-(7-Phenylheptanoyl)-pyridazin-3-yl)-picolinonitrile
US10202399, Example 18 US10463663, Example 6 CHEMBL2338797 US11129828, Example 6 BDBM50431067 US9290456, 6 US9212147, 18 US9931340, Example 6
5H-Phenanthridin-6-one 5H-Phenanthridin-6-one (PTD) Phenanthridone phenanthridin-6(5H)-one PND 6-(5H)-Phenanthridinone 5,6-dihydrophenanthridin-6-one CHEMBL45245 BDBM27500
BDBM164892 US11406644, Example 3-6 US10166239, Ex. 3-6 US9067914, Ex. 3-6
BDBM277470 US10072026, Example 2-6 US10947254, Example 2-6 US11780852, Example 2-6
BDBM277583 US10072026, Example 6-2 US10947254, Example 6-2 US11780852, Example 6-2
BDBM399563 US11220508, Compound I-6 US10323036, Compound I-6 US10793574, Compound I-6
BDBM399775 US10323036, Compound XVI-6 US10793574, Compound XVI-6 US11220508, Compound XVI-6
BDBM487329 US10947254, Example 6-8 US12358931, Example 6-8 US11780852, Example 6-8
SMR000386957 MLS001049131 cid_361939 6-oxooctadecanoic acid 6-ketostearic acid 6-oxidanylideneoctadecanoic acid BDBM69315
US10072026, Example 6-41 US10947254, Example 6-41 US12358931, Example 6-41 BDBM277622
US10072026, Example 6-42 US10947254, Example 6-42 US12358931, Example 6-42 BDBM277623
US10072026, Example 7-6 US12358931, Example 7-6 US11780852, Example 7-6 BDBM277647
US10100049, Example 1-6 BDBM292122 US11299492, Example 1-6 US11718616, Example 1-6
US10323036, Compound VIII-6 US11220508, Compound VIII-6 US10793574, Compound VIII-6 BDBM399758
US10485803, Example 1-6 US11110095, Example 1-6 US10028960, Example 1-6 BDBM279823
US10508120, Compound I-6 BDBM423551 US11046698, Compound I-6 US10577373, Compound I-6
US10947254, Example 6-25 US11780852, Example 6-25 US12358931, Example 6-25 BDBM487346
US11091495, Example 6 US20240398811, Example 6 US11485738, Example 14 US11220509, Example 6 BDBM513643
US11780852, Example 6-38 US12358931, Example 6-38 BDBM487359 US10947254, Example 6-38
US12358931, Example 3-6 US11780852, Example 3-6 BDBM277501 US10072026, Example 3-6
SMR000078244 6-[(6-methyl-2-pyridinyl)amino]-6-(trifluoromethyl)-2,3-dihydroimidazo[2,1-b]thiazol-5-one cid_2962125 BDBM87686 MLS000050734 6-[(6-methyl-2-pyridyl)amino]-6-(trifluoromethyl)-2,3-dihydroimidazo[2,1-b]thiazol-5-one 6-[(6-methylpyridin-2-yl)amino]-6-(trifluoromethyl)-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-one 6-[(6-methyl-2-pyridinyl)amino]-6-(trifluoromethyl)-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5(6H)-one
6-chloroquinolin-8-amine BDBM32205 6-chloro-8-quinolinamine cid_79618 6-chloranylquinolin-8-amine (6-chloro-8-quinolyl)amine
US10894048, Ref. Ex Comp. 6 BDBM161465 US9108973, Ref 6 US10124003, Ref. Ex. Compound 6 US10835536, Ref. Ex. Comp 6
US11584732, Example 6 BDBM372965 US10584111, Ex No. 6 US10246432, Example 6 3-(4,4′-bipyrimidin-6-yl)-5-chlorobenzonitrile
(R)-4-(Ethylsulfonamido)-N- (6-methyl-2-(2- methylmorpholino)pyrimidin- 4-yl)-2-(6-azaspiro[2.5]octan- 6-yl)benzamide BDBM535540 US11236069, Example 6-6
2-[4-(benzyl-methyl-amino)-phenoxy]- pyrido[3,4-d]pyrimidin-4-ol US10208039, Example 6 BDBM296078 US11535616, Example 6 US10815234, Example 6 US10112940, Example 6 US10611763, Example 6 US10202381, Example 6
BDBM395291 N-[6-(2-Hydroxypropan-2-yl)-2-(3-hydroxypropyl)-2H-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide US10308634, Example 6 US10793545, Example 6 US11992481, Example 6 US12006303, Example 6
(R,R)- 6 BDBM206775 US9492405, (R,R)-6
BDBM198129 4-amino-6-alkyloxy-2-benzylthiopyrimidines (6)
BDBM206776 US9492405, (R,S)-6 (R,S)-6
BDBM206777 (S,R)- 6 US9492405, (S,R)-6
BDBM206778 (S,S)-6 US9492405, (S,S)-6
BDBM213061 US9663506, Example 6-8 US9278960, 6-8
BDBM213063 US9278960, 6-10 US9663506, Example 6-10
BDBM213072 US9278960, 6-19 US9663506, Example 6-19
BDBM213073 US9278960, 6-20 US9663506, Example 6-20
BDBM213074 US9278960, 6-21 US9663506, Example 6-21
BDBM213075 US9278960, 6-22 US9663506, Example 6-22
BDBM287628 US11040034, Ex. No. 6 US10085984, Example 6
BDBM349433 US10206931, Example 241 (4R)-6-(6-benzyloxy-
BDBM36171 mono(6-carboxymethylamino-6-deoxy)-beta-cyclodextrin
BDBM50014713 CHEMBL3262022 US9951014, Name 6 US10759791, Compound 6
BDBM50300883 6-Deoxy-6-fluoro-D-fructose CHEMBL568641
BDBM50424726 US10844032, Example 6 CHEMBL2314176 US10093640, Example 6
BDBM594887 US11584756, Example S-6 US11584756, Compound 6
CHEMBL3108915 BDBM50446159 US9518026, Example 6 US9956214, Compound 6
CHEMBL3319502 BDBM50049060 US9969686, Compound 6' US10730833, Compound 6'
CHEMBL3770477 US20240158357, Example 6 BDBM50149938 US11472776, Example 6
CHEMBL4227112 US11111252, Compound 6 BDBM50461741 US11001595, Compound 6
CHEMBL54277 6-NITROINDAZOLE BDBM50284964 6-Nitro-1H-indazole
Phosphodiester analog, 6(S4A) BDBM86345 Phosphodiester analog, 6
US10457703, Example 6-ECDCA BDBM419318 US10457703, Example 6
US10676469, Compound 6 US11124504, Cpd. No. 6 BDBM450791
US10730833, Compound 6 BDBM50049065 CHEMBL3319497 US9969686, Compound 6
US10730882, Example 6 (4-Fluorobenzyl)-[6-(1H- BDBM455370
US10759787, Example 6 BDBM50287307 US11059811, Example 6 CHEMBL4176554
US10851102, Example 6 BDBM475611 US11339160, Ex No. 6
US11427590, Entry 6 BDBM50540344 US20240115574, Entry 6 CHEMBL4641651
US11873304, Example 6 BDBM524530 US11168089, Ex. No. 6
US20240358707, Compound 6 US8476284, 41 BDBM97673 US8497277, 6
US8822534, Example 6-1 US8993631, 6-1 BDBM130363
US9278960, 6-12 US9663506, Example 6-12 BDBM213065
US9278960, 6-13 BDBM213066 US9663506, Example 6-13
US9278960, 6-14 BDBM213067 US9663506, Example 6-14
US9278960, 6-17 US9663506, Example 6-17 BDBM213070
US9278960, 6-18 US9663506, Example 6-18 BDBM213071
US9278960, 6-2 BDBM213055 US9663506, Example 6-2
US9278960, 6-23 US9663506, Example 6-23 BDBM213076
US9278960, 6-24 BDBM213077 US9663506, Example 6-24
US9278960, 6-25 BDBM213078 US9663506, Example 6-25
US9278960, 6-3 BDBM213056 US9663506, Example 6-3
US9278960, 6-4 US9663506, Example 6-4 BDBM213057
US9663506, Example 6-15 US9278960, 6-15 BDBM213068
US9663506, Example 6-16 US9278960, 6-16 BDBM213069
US9663506, Example 6-26 US9278960, 6-26 BDBM213079
US9663506, Example 6-7 BDBM213060 US9278960, 6-7
US9682969, 4 US9682969, 6 US10280160, Example 6. BDBM160512
US9994550, Compound 6 BDBM397787 US20250017938, Compound 005-6
USRE48059, Compound of Example 6 BDBM194785 US9206167, 6
USRE49517, Example 6 BDBM50201022 US10155727, Example 6 CHEMBL3897632
[6]-gingerol BDBM50275147 Gingerol BDBM50317427 CHEMBL446043 6-Gingerol
8-aminoquinolin-6-ol BDBM40741 8-amino-6-quinolinol cid_244284 8-azanylquinolin-6-ol
BDBM50329780 CHEMBL1269790 5-N,6-S-[N'-[4-(6-Dansylaminohexanamido)butyl]iminomethylidene]-6-thionojirimycin
US8614253, 3-6 BDBM110975 US9241942, 3-6 US8614253, 43-4 US9963434, Compound 3-6
US9926330, 6-2 N-((trans)-4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)cyclohexyl)-6-methylquinazolin-4-amine BDBM380593
BDBM411861 US10392391, Compound I-O-6 US10787452, Compound I-O-6 US11117900, Compound I-O-6 US11370798, Cmpd. # I-O-6 US20230271963, Compound I-O-6
US11370798, Cmpd. # I-G-6 BDBM412036 US20230271963, Compound I-G-6 US10392391, Compound I-G-6 US10787452, Compound I-G-6 US11117900, Compound I-G-6
US10736890, Compound TABLE C.6 US10752592, Compound TABLE D.6 US11534436, Compound Table C.6 US9656961, Example 00170 BDBM179902 US10231963, Table C.6 US9133125, Table D, Compound 6 US10287250, Compound D.6
SMR000353513 BDBM82825 N-[6-[2-(furan-2-ylmethylidene)hydrazinyl]-6-oxohexyl]benzamide cid_2131615 MLS001017300 N-[6-[2-(furan-2-ylmethylidene)hydrazinyl]-6-oxidanylidene-hexyl]benzamide N-[6-[2-(2-furanylmethylidene)hydrazinyl]-6-oxohexyl]benzamide N-[6-[N'-(2-furfurylidene)hydrazino]-6-keto-hexyl]benzamide
US10342794, Example Ex.-6 US9931338, Ex.-6 US9290505, Ex.-6 US9504684, Ex.-6 BDBM212275 2-((4-(4-((6-(6-aminopyrazin-2-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)piperazin-1-yl)methyl)propane-1,3-diol US10828299, Example Ex.-6 US11517570, Example Ex.-6:
6-keto-2,4-dimethyl-N-(6-quinolyl)pyran-3-carboxamide 2,4-dimethyl-6-oxidanylidene-N-quinolin-6-yl-pyran-3-carboxamide 2,4-dimethyl-6-oxo-N-(6-quinolinyl)-3-pyrancarboxamide cid_930454 2,4-dimethyl-6-oxo-N-quinolin-6-ylpyran-3-carboxamide BDBM50909 MLS000556567 SMR000147884 2,4-Dimethyl-6-oxo-6H-pyran-3-carboxylic acid quinolin-6-ylamide
6-Hydroxyflavone, 10 6-Hydroxyflavone CHEMBL138649 NSC-26744 6-hydroxy-2-phenyl-4H-chromen-4-one 6-Hydroxy-2-phenyl-chromen-4-one 6-hydroxy-flavone BDBM50081950
US9598421, Example 6 BDBM285533 US10669279, Example 6 N-Cyclopropyl-3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazo[1,2-b]pyridazine-2-carboxamide (6) US10077269, Example 6
BDBM481167 2-(6-Methylpyridin-2-yl)-3-(quinoxalin-6-yl)-5,6,7,8-tetrahydro-5,8-methanoimidazo[1,2-a]pyridine 6 US10906905, Example 6
BDBM50154102 2-(6-Hydroxy-naphthalen-2-yl)-benzooxazol-6-ol 2-(6-hydroxynaphthalen-2-yl)benzo[d]oxazol-6-ol CHEMBL187314
BDBM61328 N-(6-quinolinyl)benzamide cid_833617 N-Quinolin-6-yl-benzamide N-(6-quinolyl)benzamide N-quinolin-6-ylbenzamide MLS001206107 SMR000517972
CHEMBL189077 BDBM50154135 2-(6-hydroxynaphthalen-1-yl)benzo[d]oxazol-6-ol 2-(6-Hydroxy-naphthalen-1-yl)-benzooxazol-6-ol
MLS001178412 cid_817513 2-phenyl-6-quinoxalinamine 2-phenylquinoxalin-6-amine (2-phenylquinoxalin-6-yl)amine SMR000475720 BDBM83243 2-phenylquinoxalin-6-ylamine
US10787452, Compound I-C-6 US11117900, Compound I-C-6 US20230271963, Compound I-C-6 BDBM464792 US11370798, Cmpd. # I-C-6
[6-[(6-methylpyrimidin-4-yl)thio]-5-nitro-pyrimidin-4-yl]amine MLS000665061 SMR000294763 6-[(6-methyl-4-pyrimidinyl)thio]-5-nitro-4-pyrimidinamine 6-(6-methylpyrimidin-4-yl)sulfanyl-5-nitro-pyrimidin-4-amine cid_612628 BDBM65325 6-(6-methylpyrimidin-4-yl)sulfanyl-5-nitropyrimidin-4-amine
BDBM202374 US9238629, I-14 US9238629, I-6 US9765038, Compound I-6 US10081606, Compound I-6
BDBM8987 6-chlorotacrine 6-chlorotacrine.HCl Tacrine Analogue 4 CHEMBL486698 6-chloro-1,2,3,4-tetrahydroacridin-9-amine
US11311527, Cpd ID I-6 US11376246, Cpd ID I-6 BDBM550716 US11576906, Compound I-6
US9062078, 4 BDBM163869 US9062078, 6 US9062078, 5A US9062078, 5B US9637496, 6 US9475819, 4 US9695183, 6
3-(6-hydroxynaphthalen-2-yl)benzo[d]isoxazol-6-ol 3-(6-Hydroxy-naphthalen-2-yl)-benzo[d]isoxazol-6-ol BDBM50154137 CHEMBL187105 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL
US10112942, Example 6 US10137124, Example 6 US10555944, Example 6 US10953005, Example 10 BDBM296199 4-(6-(4-benzylpiperazin- 1-yl)pyridin-3-yl)-6-(2- ethoxyethoxy)pyrazolo [1,5-a]pyridine-3- carbonitrile US10172851, Example 6
MLS000050741 SMR000078259 cid_2962157 BDBM87688 6-[(6-mesyl-1,3-benzothiazol-2-yl)amino]-6-(trifluoromethyl)-2,3-dihydroimidazo[2,1-b]thiazol-5-one 6-[(6-methylsulfonyl-1,3-benzothiazol-2-yl)amino]-6-(trifluoromethyl)-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-one 6-[(6-methylsulfonyl-1,3-benzothiazol-2-yl)amino]-6-(trifluoromethyl)-2,3-dihydroimidazo[2,1-b]thiazol-5-one 6-{[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]amino}-6-(trifluoromethyl)-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5(6H)-one
4,6-Dibromo-2-(2'-methoxy-4',6'-dibromophenoxy)phenol 2,4-Dibromo-6-(2,4-dibromo-6-methoxy-phenoxy)-phenol BDBM50150777 CHEMBL186099 2,4-dibromo-6-(2,4-dibromo-6-methoxyphenoxy)phenol
BAP 6-BAP 6-[(phenylmethyl)amino]-9H-purine CHEMBL228862 N-benzyladenine 6-(benzylamino)purine BDBM50205363 Cytokinin B benzyladenine N(6)-(benzylamino)purine N-benzyl-9H-purin-6-amine
(4R)-4-methyl-6-(6- US10206931, Example 248 BDBM349440
(4R)-6-(6-amino-5- US10206931, Example 250 BDBM349442
(4R)-6-[6-amino-5- US10206931, Example 249 BDBM349441
2-(6-(4-(3-cyano-4- BDBM264719 US9718780, 6
2-hydroxy-6-(6-hydroxyhexyl)benzoic acid CHEMBL1784990 BDBM50345789
6-(biphenyl-3-ylamino)-6-oxohexyl sulfamate BDBM50277255 CHEMBL475307
6-Shogaol Trans-6-Shogaol SHOGAOL BDBM50237536 CHEBI:10138
6-[6-(3-chloro-5- BDBM594149 US11584732, Example 3
BDBM159184 US9682968, Example-5-6 US10093663, Example 5-6
BDBM159320 US10093663, Example 17-6 US9682968, Example-17-6
BDBM249879 US9447106, 6 US9556188, Compound 6 US10005782, Compound 6b
BDBM279842 US11110095, Example 2-6 US10028960, Example 2-6
BDBM325810 US9637472, Compound A-6 US10273223, Compound A-6
BDBM349432 US10206931, Example 240 (4R)-6-(6-amino-3-
BDBM349455 US10206931, Example 263 (4R)-6-(6-methoxy-3-
BDBM401324 US10005762, Example 6(2) US10005762, Example 6(1)
BDBM405592 US10351547, Compound 2-6 US10597377, Compound 2-6
BDBM439606 US10633389, Example 6-1 US20230279020, Example 6-1
BDBM441817 US10851050, Example I-6 US10647665, Example 1-6
BDBM442063 US11396508, Compound I-6 US10647713, Compound I-6
BDBM456943 US10738007, Compound ID 6 US11555039, Compound ID 6
BDBM50032494 N-[6-(6-Guanidino-hexylamino)-hexyl]-guanidine CHEMBL317697
BDBM50277290 N-(quinolin-6-yl)-6-(sulfamoylamino)hexanamide CHEMBL454438
BDBM50345784 CHEMBL1784983 ethyl 2-hydroxy-6-(6-hydroxyhexyl)benzoate
BDBM50490818 R-(+)-MARMIN-6'-LINOLEATE R-(+)-Marmin-6''-linoleate
BDBM565440 US12221453, Compound I-6 US11414431, Compound I-6
BDBM578951 US11492351, Example 6-1 US11479551, Example 6-1
BDBM614301 US20230270730, Compound B-6 US11964950, Compound B-6
BDBM614316 US20230270730, Compound C-6 US11964950, Compound C-6
BDBM614369 US11964950, Compound G-6 US20230270730, Compound G-6
BDBM614402 US20230270730, Compound K-6 US11964950, Compound K-6
BDBM645021 US11981682, Example 3-6 US20240010658, Example 3-6
Boronic acid, cis-6 Boronic acid, trans-6 BDBM59225
GlcN-6-P synthase inhibitor, 6 (racemic mixture) BDBM85313
N-(6-methylpyridin-2-yl)-6-phenylnicotinamide BDBM50258376 CHEMBL525384
N-[6-(6-Amino-hexylamino)-hexyl]-guanidine CHEMBL103266 BDBM50032502
R-(+)-MARMIN-6'-OCTANOATE R-(+)-Marmin-6''-octanoate BDBM50490820
R-(+)-Marmin-6''-palmitate R-(+)-MARMIN-6'-PALMITATE BDBM50490810
R-(+)-Marmin-6''-undecanoate R-(+)-MARMIN-6'-UNDECANOATE BDBM50490811
US10072026, Example 8-6 US10947254, Example 8-6 BDBM277657
US10092556, Comparative Example 6 US9346787, Comparative Example 6 BDBM231252
US10206907, Compound 130 US8563545, 6 US11000528, Cpd # 6 BDBM103732
US10206931, Example 247 (4R)-4-methyl-6-[6- BDBM349439
US10351547, Compound 1-6 US10597377, Compound 1-6 BDBM405558
US10428074, Example 6 US9527851, 6 US9527851, example 112 BDBM260453
US10538496, Compound II-6 BDBM421735 US10508088, Example II-6
US10544151, Compound I-6 US10954244, Compound I-6 BDBM428833
US10550091, No. LC-6 BDBM429597 US10947203, No. LC-6
US10633389, Example 6-3 US20230279020, Example 6-3 BDBM440341
US10934305, Compound HK-6 US10077273, Compound HK-6 BDBM285676
US10947254, Example 6-47 US11780852, Example 6-47 BDBM487368
US10947254, Example 6-53 US12358931, Example 6-53 BDBM487374
US10961232, Compound I-6 BDBM420333 US10479784, Compound I-6
US10961232, Compound IA-6 US10479784, Compound IA-6 BDBM420489
US10961232, Compound VII-6 BDBM420946 US10479784, Compound VII-6
US11208415, Example I-6 BDBM428901 US10533010, Example I-6
US11325908, Compound I-6 BDBM458831 US10759792, Compound I-6
US11434240, Compound I-6 US10781204, Compound I-6 BDBM463572
US11472782, Compound I-6 US11407736, Compound I-6 BDBM562767
US11479551, Example 12-6 US11492351, Example 12-6 BDBM579083
US11479551, Example 6-5 US11492351, Example 6-5 BDBM578960
US11479551, Example 9-6 BDBM579044 US11492351, Example 9-6
US11731934, Compound RLS3-6 BDBM468605 US10807944, Compound RLS3-6
US11780852, Example 6-37 US12358931, Example 6-37 BDBM625024
US11780852, Example 6-49 BDBM487370 US10947254, Example 6-49
US11964950, Compound E-6 US20230270730, Compound E-6 BDBM614340
US11964950, Compound P-6 US20230270730, Compound P-6 BDBM614420
US11981682, Example 2-6 BDBM645018 US20240010658, Example 2-6
US11981682, Example 6-2 US20240010658, Example 6-2 BDBM645026
US12297164, Example 6 Compound prepared in Example 6 BDBM738179
US12358931, Example 6-24 BDBM625011 US11780852, Example 6-24
US12358931, Example 6-27 BDBM487348 US10947254, Example 6-27
US12358931, Example 8-6 US11780852, Example 8-6 BDBM625063
US20230270730, Compound A-6 BDBM319596 US11964950, Compound A-6
US20230270730, Compound D-6 US11964950, Compound D-6 BDBM614322
US20230270730, Compound J-6 US11964950, Compound J-6 BDBM614387
US20230279020, Example 6-1a BDBM439698 US10633389, Example 6-1a
US20230279020, Example 6-2 US10633389, Example 6-2 BDBM439682
US8742115, 19 US10213421, Example 6 BDBM123080 US11612596, Example 6.
US8865911, 6 US9918985, Example 7 BDBM136916 US10231967, Example 6
US9062048, (+) 4 US9062048, (-) 4 US9062048, (+) 6 BDBM163602 US9062048, (-) 6
US9120780, Comparative Example 6 BDBM126169 US8779142, Comparative Example 6
US9493435, 180 BDBM111370 US9241942, 32-6 US8614253, 32-6
US9604926, Compound SC-6 US9724435, Compound SC-6 BDBM312227
US9637472, Compound B-6 US10273223, Compound B-6 BDBM325912
US9637472, Compound C-6 US10273223, Compound C-6 BDBM326073
US9637472, Compound D-6 BDBM326108 US10273223, Compound D-6
US9751854, Compound I-6 BDBM337823 US9802960, Compound I-6
US9908872, Compound (I-6) BDBM375307 US10597387, Compound (I-6)
mono[6-O-6-(4-carboxylphenyl)]-beta-cyclodextrin BDBM36252
(6-bromo-8-quinolyl)amine 6-bromanylquinolin-8-amine 6-bromo-8-quinolinamine cid_93637 BDBM32197 TG2-38-2 6-bromoquinolin-8-amine
6-(((1-((6-chloropyridin-3- yl)amino)isoquinolin-6- yl)oxy)methyl)-2- oxaspiro[3.3]heptane-6- carbonitrile BDBM660947 US20240101531, Example 333
6-(6'-6-(6'-(2-hydroxypropan-2-yl)-[2,2'- bipyridin]-3-yl)imidazo[1,2-a]pyridine-3- carbonitrile US9981944, Example 41 BDBM396696
6-(benzenesulfonyl)-3-pyridinesulfonamide SMR000476535 6-(phenylsulfonyl)pyridine-3-sulfonamide BDBM66683 cid_819426 6-(benzenesulfonyl)pyridine-3-sulfonamide MLS001180448 6-besylpyridine-3-sulfonamide
BDBM50251960 3-(6-(9H-purin-6-ylamino)hexanamido)-N-butylbenzamide CHEMBL521105 N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide
BDBM68689 SMR000116446 cid_838817 N-(phenylmethyl)-6-quinoxalinecarboxamide N-(phenylmethyl)quinoxaline-6-carboxamide N-benzylquinoxaline-6-carboxamide Quinoxaline-6-carboxylic acid benzylamide MLS000525972
cid_804795 6-(1,4,5,7-tetramethylpyrrolo[3,4-d]pyridazin-6-yl)quinoline SMR000287861 6-(1,4,5,7-tetramethyl-6-pyrrolo[3,4-d]pyridazinyl)quinoline BDBM94876 MLS000708394
US10544120, Example 6 (S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-(trifluoromethoxy)phenyl)pyridin-2-yl)acetamide BDBM311158 US10981910, Example 6 US9902722, Example 6 US10155760, Example 6 US10351563, Example 6 US10723734, Example 6
cid_654879 MLS000032387 Quinoxaline-6-carboxylic acid (2,3-dihydro-benzo[1,4]dioxin-6-yl)-amide SMR000003763 BDBM96092 N-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-quinoxalinecarboxamide N-(2,3-dihydro-1,4-benzodioxin-6-yl)quinoxaline-6-carboxamide
7-Hydroxy-6-methoxy-2H-1-benzopyran-2-one 6-Methylesculetin 6-O-Methylesculetin CHEMBL71851 BDBM50156693 6-Methoxy-7-hydroxycoumarin 7-hydroxy-6-methoxy-2H-chromen-2-one scopoletin
6-((5-chloro-2-methoxy-4-(2-methoxy-6-((trifluoromethyl)-4- BDBM444934 US10668067, Example 2-6
6-(2-cyanophenoxy)- 4-(6-methylpyridin-2- ylamino)pyridazine- 3-carboxamide BDBM295264 US10112928, Compound I-6
6-[2-(1H-indol-6-yl)ethyl]pyridin-2-amine BDBM15779 6-Substituted 2-Aminopyridine 3
BDBM164909 US10166239, Ex. 3-18-6 US11406644, Example 3-18-6 US9067914, Ex. 3-18-6
BDBM164938 US10166239, Ex. 3-37-6 US9067914, Ex. 3-37-6 US11406644, Example 3-37-6
BDBM423275 US10501451, Example 6, P-2 US10954225, Example 6,P-2 US10501451, Example 6, P-1
CHEMBL361078 BDBM20731 Benzisoxazole, 6 4-bromo-6-(6-hydroxy-1,2-benzoxazol-3-yl)benzene-1,3-diol
US20240317756, Compound 6 US9133201, 9 US9278100, 6 US9181263, 6 US8476284, 9 US8497277, 10 BDBM97678 US8497277, 9
6-(2,3-dihydro-1,4-benzodioxin-6-ylcarbamoylamino)hexanoic acid MLS000551585 cid_4360734 BDBM59855 6-[3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-ureido]-hexanoic acid SMR000145510 6-[[(2,3-dihydro-1,4-benzodioxin-6-ylamino)-oxomethyl]amino]hexanoic acid
MLS000863722 7-[6-(4-benzylpiperazin-1-yl)-6-oxohexyl]-6-sulfanylidene-5H-[1,3]dioxolo[4,5-g]quinazolin-8-one 7-[6-oxidanylidene-6-[4-(phenylmethyl)piperazin-1-yl]hexyl]-6-sulfanylidene-5H-[1,3]dioxolo[4,5-g]quinazolin-8-one SMR000030909 7-[6-(4-benzylpiperazino)-6-keto-hexyl]-6-thioxo-5H-[1,3]dioxolo[4,5-g]quinazolin-8-one 7-[6-oxo-6-[4-(phenylmethyl)-1-piperazinyl]hexyl]-6-sulfanylidene-5H-[1,3]dioxolo[4,5-g]quinazolin-8-one BDBM62490 cid_3237561 7-[6-(4-benzylpiperazin-1-yl)-6-oxohexyl]-6-thioxo-6,7-dihydro[1,3]dioxolo[4,5-g]quinazolin-8(5H)-one
2-(6-chloropyridin-3-yl)-6-aza-bicyclo[2.2.1]heptane 6-(6-Chloro-pyridin-3-yl)-2-aza-bicyclo[2.2.1]heptane CHEMBL185667 BDBM50194069
6-(2-(1-oxa-6- azaspiro[3.3]heptan-6- yl)ethoxy)-N-(6-chloropyridin- 3-yl)isoquinolin-1-amine US20240101531, Example 70 BDBM660685
CHEMBL111567 6-Carbamimidoyl-naphthalene-2-carboxylic acid (1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide BDBM50138656 6-carbamimidoyl-N-(1,2,3,4-tetrahydroisoquinolin-6-yl)-2-naphthamide
CHEMBL187393 3-(6-hydroxynaphthalen-1-yl)benzo[d]isoxazol-6-ol 3-(6-Hydroxy-naphthalen-1-yl)-benzo[d]isoxazol-6-ol BDBM50154087
US10173996, Example 6 2-(5-hydroxy-3-propyl-1H- pyrazol-1-yl)isonicotinic acid US9714230, 6 BDBM263936 US9604961, Example 6 US9908865, Example 6
US10246456, Example 120 1-(6-(1-(6-ethylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine 2-bromo-6-ethylpyridine BDBM374111
US20240101531, Example 73 BDBM660688 6-(2-(2-oxa-6- azaspiro[3.3]heptan-6- yl)ethoxy)-N-(6-chloropyridin- 3-yl)isoquinolin-1-amine
US11236069, Example 11-31 4-((2-Hydroxyethyl)sulfonamido)-N- (6-methyl-2-(6- azaspiro[2.5]octan-6- yl)pyrimidin-4-yl)-2-(6- azaspiro[2.5]octan-6- yl)benzamide BDBM535620
2-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-methyl-quinoline-4-carboxylic acid 2-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-methylquinoline-4-carboxylic acid MLS000031704 SMR000012473 cid_648129 2-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-6-methyl-quinoline-4-carboxylic acid 2-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-methyl-cinchoninic acid 2-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-methyl-4-quinolinecarboxylic acid BDBM71631
6-(3-((8-methoxy-2-(6-methoxypyridin-3-yl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-3H-imidazo[4,5-b]pyridin-6-yl)-2-oxa-6-azaspiro[3.3]heptane US11274108, Example 1-57 6-(3-((8-methoxy-2-(6-methoxypyridin-3-yl)-2,3- dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-3H-imidazo[4,5- b]pyridin-6-yl)-2-oxa-6-azaspiro[3.3]heptane BDBM542757
6-Chloro-2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-chromen-4-one 6-chloro-2-(2,3-dihydro-1,4-benzodioxin-6-yl)chromone BDBM49615 cid_683499 MLS000590494 6-chloranyl-2-(2,3-dihydro-1,4-benzodioxin-6-yl)chromen-4-one SMR000217533 6-chloro-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-benzopyran-4-one 6-chloro-2-(2,3-dihydro-1,4-benzodioxin-6-yl)chromen-4-one
cid_1714073 3-[(2-chloro-6-methyl-4-pyrimidinyl)oxy]-1H-pyridazin-6-one 3-(2-chloro-6-methyl-pyrimidin-4-yl)oxy-1H-pyridazin-6-one 6-(2-Chloro-6-methyl-pyrimidin-4-yloxy)-pyridazin-3-ol SMR000413230 3-(2-chloro-6-methylpyrimidin-4-yl)oxy-1H-pyridazin-6-one MLS000776832 3-(2-chloranyl-6-methyl-pyrimidin-4-yl)oxy-1H-pyridazin-6-one BDBM66644
MLS002638275 cid_44825960 SMR001547764 6-methoxy-5-[(6-methoxy-5-quinolinyl)methyl]quinoline;sulfuric acid 6-methoxy-5-[(6-methoxyquinolin-5-yl)methyl]quinoline;sulfuric acid BDBM94961 6-methoxy-5-[(6-methoxy-5-quinolyl)methyl]quinoline;sulfuric acid
US9730939, Example 6 US10646492, Example 6 US9707233, 6 US10092570, Example 6 1-{1-[5-Chloro-3-(1-ethylazetidin-3-yl)-2-methoxy-4-methylphenyl]ethyl}-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine US11433071, Example 6 US10376513, Example 6 US9932341, Example 6 BDBM255795
BDBM101315 US9695151, 6
BDBM101429 US8524710, 6
BDBM101858 US9695163, 6
BDBM101914 US8536227, 6
BDBM102111 US9695165, 6
BDBM102448 US8536165, 6
BDBM102930 US8541447, 6
BDBM102978 US8546435, 6
BDBM104515 US8575201, 6
BDBM104969 US8569306, 6
BDBM104984 US8569291, 6
BDBM105062 US8569281, 6
BDBM127508 US8791100, 6
BDBM129673 US8802665, 6
BDBM129718 US8802672, 6
BDBM129727 US8815926, 6
BDBM162249 US9051311, 6
BDBM162329 US9051321, 6
BDBM163604 US9062048, (-) 6
BDBM163605 US9062048, (+) 6
BDBM164506 US9067871, 6
BDBM165672 US9067922, 6
BDBM166039 US9067935, 6
BDBM166063 US9067937, 6
BDBM166438 US9073833, 6
BDBM166447 US9073853, 6
BDBM191670 US9186360, 6
BDBM191881 US9187429, 6
BDBM192015 Inz-6
BDBM192252 US9187450, 6
BDBM192482 US9187469, 6
BDBM192510 US9187477, 6
BDBM192544 US9187486, 6
BDBM192776 US9187487, 6
BDBM192833 US9192603, 6
BDBM194825 US9206184, 6
BDBM194882 US9670211, 6
BDBM196813 US9212186, 6
BDBM197653 US9216972, 6
BDBM197678 US9216981, 6
BDBM197996 US9221790, 6
BDBM201559 US9233979, 6
BDBM202045 US9233981, 6
BDBM202241 US9238619, 6
BDBM202399 US9238644, 6
BDBM202597 US9242943, 6
BDBM202642 US9242957, 6
BDBM202870 US9242970, 6
BDBM204412 US9242996, 6
BDBM204528 US9242998, 6
BDBM204587 US9243002, 6
BDBM204882 US9260454, 6
BDBM205481 PDD00031704 (6)
BDBM205500 US9253997, 6
BDBM205537 US9255090, 6
BDBM221080 US9303012, 6
BDBM221307 US9303023, 6
BDBM231226 US9346782, 6
BDBM231259 US9346798, 6
BDBM231571 US9345700, 6
BDBM231655 DSer (6)
BDBM233116 Nostotrebin 6
BDBM233368 US9346829, 6
BDBM233399 US9351965, 6
BDBM233878 US9353090, 6
BDBM234875 US9359337, 6
BDBM236228 US9365575, 6
BDBM236253 US9365576, 6
BDBM236558 US9365572, 6
BDBM236639 US9388139, 6
BDBM237080 US9388198, 6
BDBM237097 US9388199, 6
BDBM259495 US9505749, 6
BDBM259638 US9505762, 6
BDBM259903 US9512115, 6
BDBM336133 US9744148, 6
BDBM337537 US9745324, 6
BDBM363895 US9856239, 6
BDBM402290 US10011627, 6
BDBM77157 US9695118, 6
US8524717, 6 BDBM101251
US8530648, 6 BDBM102136
US8536173, 6 BDBM102431
US8536210, 6 BDBM102357
US8575145, 6 BDBM104129
US8575364, 6 BDBM104997
US8791130, 6 BDBM127876
US8791268, 6 BDBM127305
US8796296, 6 BDBM128251
US8796297, 6 BDBM128103
US8796310, 6 BDBM127959
US8796328, 6 BDBM128029
US9056843, 6 BDBM162715
US9062045, 6 BDBM163167
US9062078, 6 BDBM163872
US9067924, 6 BDBM165912
US9073821, 6 BDBM166391
US9090621, 6 BDBM197177
US9182402, 6 BDBM191633
US9187428, 6 BDBM191778
US9206129, 6 BDBM194590
US9206164, 6 BDBM196945
US9206173, 6 BDBM195618
US9206198, 6 BDBM194952
US9206199, 6 BDBM195913
US9212171, 6 BDBM196681
US9216988, 6 BDBM197784
US9227979, 6 BDBM204858
US9249125, 6 BDBM205254
US9249151, 6 BDBM205360
US9255096, 6 BDBM205990
US9260417, 6 BDBM205483
US9346786, 6 BDBM233202
US9353081, 6 BDBM233809
US9353093, 6 BDBM234584
US9353101, 6 BDBM234610
US9353102, 6 BDBM234683
US9353104, 6 BDBM234718
US9353116, 6 BDBM234849
US9359330, 6 BDBM234214
US9365853, 6 BDBM236495
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ChEMBL_537868 (CHEMBL990680) Inhibition of human recombinant caspase 6 assessed as accumulation of 7-amino-4-methylcoumarin substrate
ChEMBL_523092 (CHEMBL1006644) Inhibition of human recombinant caspase 6 assessed as accumulation of cleaved fluorogenic 7-amino-4-methylcoumarin after 10 mins
ChEMBL_812483 (CHEMBL2014319) Inhibition of human recombinant DPP4 using H-Gly-Pro-7-amino-4-methylcoumarin as substrate assessed as inhibition of 7-amino-4-methylcoumarin formation after 30 mins by fluorimetry
ChEMBL_1908756 (CHEMBL4411114) Inhibition of PREP in C57BL/6 mouse cortex homogenate assessed as formation of 7-amido-4-methylcoumarin using Suc-Gly-Pro-amido-4-methylcoumarin as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluorometric assay
ChEBML_1549624 Inhibition of human NMT1 by 7-diethylamine-3-(4'maleimidylphenyl)-4-methylcoumarin based fluorescence assay
ChEMBL_2355655 Inhibition of human recombinant DPP-4 using Gly-Pro-7-amido-4-methylcoumarin as substrate
ChEMBL_659716 (CHEMBL1246138) Inhibition of human recombinant caspase 7 assessed as fluorescent 7-amido-4-methylcoumarin release
ChEMBL_659717 (CHEMBL1246139) Inhibition of human recombinant caspase 3 assessed as fluorescent 7-amido-4-methylcoumarin release
ChEMBL_956327 (CHEMBL2379561) Inhibition of human MAGL expressed in Escherichia coli using 6-methoxy-4-methylcoumarin ester as substrate after 3 hrs by mass spectroscopic analysis
ChEMBL_1549624 (CHEMBL3756684) Inhibition of human NMT1 by 7-diethylamine-3-(4'maleimidylphenyl)-4-methylcoumarin based fluorescence assay
ChEMBL_537865 (CHEMBL990676) Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrate
ChEMBL_537866 (CHEMBL990677) Inhibition of human recombinant caspase 7 assessed as accumulation of 7-amino-4-methylcoumarin substrate
ChEMBL_537867 (CHEMBL990679) Inhibition of human recombinant caspase 1 assessed as accumulation of 7-amino-4-methylcoumarin substrate
ChEMBL_537869 (CHEMBL990681) Inhibition of human recombinant caspase 8 assessed as accumulation of 7-amino-4-methylcoumarin substrate
ChEMBL_1856664 (CHEMBL4357393) Inhibition of activated human coagulation factor IX using 7-amino-4-methylcoumarin as substrate by spectrofluorimetry
ChEMBL_1927715 (CHEMBL4430787) Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 10 hrs measured every 6 mins by fluorescence assay
ChEMBL_1463431 (CHEMBL3399768) Inhibition of bovine plasma thrombin using Benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin hydrochloride by spectrophotometry
ChEMBL_2103469 (CHEMBL4811972) Inhibition Dengue serotype-2 NS3B/NS3 protease using 7-amino-4-methylcoumarin as substrate by fluorescence assay
ChEMBL_2103471 (CHEMBL4811974) Inhibition West Nile virus NS3B/NS3 protease using 7-amino-4-methylcoumarin as substrate by fluorescence assay
ChEMBL_740158 (CHEMBL1763218) Inhibition of CYP2D6 fluorescent probe 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy-4-methylcoumarin
ChEMBL_2076054 (CHEMBL4731588) Inhibition of IRAK4 (unknown origin) using methylcoumarin-labeled peptide as substrate in presence of ATP by FRET assay
ChEMBL_2455737 Inhibition of human liver Cathepsin L using Z-Phe-Arg7-amido-4-methylcoumarin hydrochloride as substrate by FRET assay
ChEMBL_759351 (CHEMBL1809814) Inhibition of human plasma thrombin benzoyl-Phe-Val-Arg-7-amino-4-methylcoumarin as substrate by spectrophotometric analysis
ChEMBL_1908755 (CHEMBL4411113) Inhibition of recombinant porcine brain PREP expressed in Escherichia coli assessed as formation of 7-amido-4-methylcoumarin using Suc-Gly-Pro-amido-4-methylcoumarin as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluorometric assay
ChEMBL_1551210 (CHEMBL3761791) Inhibition of human recombinant HDAC1 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assay
ChEMBL_1551211 (CHEMBL3761792) Inhibition of human recombinant HDAC2 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assay
ChEMBL_1551212 (CHEMBL3761793) Inhibition of human recombinant HDAC3 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assay
ChEMBL_1551371 (CHEMBL3762492) Inhibition of human recombinant HDAC6 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assay
ChEMBL_1745981 (CHEMBL4180491) Inhibition of recombinant Trypanosoma cruzi cruzain using Z-phe-Arg-7-amido-4-methylcoumarin as substrate by fluorometric method
ChEMBL_1875048 (CHEMBL4376337) Inhibition of recombinant human cathepsin V using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate by fluorescence assay
ChEMBL_523090 (CHEMBL1004120) Inhibition of human recombinant caspase 1 assessed as accumulation of cleaved fluorogenic 7-amino-4-methylcoumarin after 10 mins
ChEMBL_523091 (CHEMBL1004121) Inhibition of human recombinant caspase 3 assessed as accumulation of cleaved fluorogenic 7-amino-4-methylcoumarin after 10 mins
ChEMBL_523093 (CHEMBL1006645) Inhibition of human recombinant caspase 7 assessed as accumulation of cleaved fluorogenic 7-amino-4-methylcoumarin after 10 mins
ChEMBL_759352 (CHEMBL1809815) Inhibition of human urine urokinase using benzyloxycarbonyl-Gly-Gly-Arg-7-amino-4-methylcoumarin as substrate by spectrophotometric analysis
ChEMBL_969014 (CHEMBL2400603) Inhibition of CYP2D6 (unknown origin) expressed in baculovirus-infected insect cell microsomes assessed as 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy-4-methylcoumarin conversion to 3-[2-(N,N-diethylamino)ethyl]-7-hydroxy-4-methylcoumarin after 45 mins by fluorescence assay
ChEMBL_2284255 Inhibition of DPP4 (unknown origin) using Gly-Pro-7-amido-4-methylcoumarin as substrate incubated for 30 mins by fluorescence analysis
ChEMBL_2347558 Inhibition of human recombinant glutaminyl cyclase using glutaminyl-7-amido-4-methylcoumarin as substrate assessed as inhibition constant by microplate reader analysis
ChEMBL_972955 (CHEMBL2412036) Inhibition of human pancreatic chymotrypsin using Suc-Ala-Ala-Pro-7-amino-4-methylcoumarin as substrate by fluorescence microplate reader analysis
ChEBML_1623657 Inhibition of full length recombinant human HDAC2 expressed in baculovirus expression system assessed as release of 7-amino-4-methylcoumarin by fluorogenic assay
ChEBML_1623658 Inhibition of full length recombinant human HDAC6 expressed in baculovirus expression system assessed as release of 7-amino-4-methylcoumarin by fluorogenic assay
ChEBML_1684759 Inhibition of HDAC1 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate after 15 mins by fluorescence assay
ChEBML_1684760 Inhibition of HDAC2 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate after 15 mins by fluorescence assay
ChEMBL_1977317 (CHEMBL4610452) Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay
ChEMBL_2274139 Inhibition of HDAC1 (unknown origin) using acetylated 7-amino-4-methylcoumarin (AMC) as peptide substrate measured after 20 mins by fluorescence based analysis
ChEMBL_2274140 Inhibition of HDAC2 (unknown origin) using acetylated 7-amino-4-methylcoumarin (AMC) as peptide substrate measured after 20 mins by fluorescence based analysis
ChEMBL_2274141 Inhibition of HDAC3 (unknown origin) using acetylated 7-amino-4-methylcoumarin (AMC) as peptide substrate measured after 20 mins by fluorescence based analysis
ChEMBL_2476741 Inhibition of USP1-UAF1 complex (unknown origin) using Ub-7-amido-4-methylcoumarin as substrate incubated for 2 hrs by fluorescence based analysis
ChEMBL_744275 (CHEMBL1772082) Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay
ChEMBL_744276 (CHEMBL1772083) Inhibition of full length HDAC8 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay
ChEMBL_1450737 (CHEMBL3363612) Inhibition of pig pancreas trypsin type IX-S using Boc-Gln-Ala-Arg-MCA substrate by 7-amino-4-methylcoumarin release based spectrofluorometry
ChEMBL_1684760 (CHEMBL4035239) Inhibition of HDAC2 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate after 15 mins by fluorescence assay
ChEMBL_1684761 (CHEMBL4035240) Inhibition of HDAC3 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate after 15 mins by fluorescence assay
ChEMBL_1684762 (CHEMBL4035241) Inhibition of HDAC6 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate after 15 mins by fluorescence assay
ChEMBL_1684763 (CHEMBL4035242) Inhibition of HDAC7 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate after 15 mins by fluorescence assay
ChEMBL_1684764 (CHEMBL4035243) Inhibition of HDAC10 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate after 15 mins by fluorescence assay
ChEMBL_1793167 (CHEMBL4265086) Competitive inhibition of human neutrophil elastase using N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methylcoumarin as substrate by Dixon plot analysis
ChEMBL_1976996 (CHEMBL4610131) Inhibition of HDAC8 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate after 30 mins by fluorescence assay
ChEMBL_2284231 Inhibition of human recombinant DPP4 using Gly-Pro-7-amido-4-methylcoumarin hydrobromide as substrate incubated for 30 mins by fluorescence microplate reader analysis
ChEMBL_2284232 Inhibition of human recombinant DPP8 using Gly-Pro-7-amido-4-methylcoumarin hydrobromide as substrate incubated for 30 mins by fluorescence microplate reader analysis
ChEMBL_2284233 Inhibition of human recombinant DPP9 using Gly-Pro-7-amido-4-methylcoumarin hydrobromide as substrate incubated for 30 mins by fluorescence microplate reader analysis
ChEMBL_2460624 Inhibition of HDAC8 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate measured after 30 mins by fluorescence assay
ChEMBL_744274 (CHEMBL1772081) Inhibition of full length HDAC3/NCoR2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay
ChEMBL_861418 (CHEMBL2174032) Inhibition of human recombinant HDAC6 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay
ChEMBL_861541 (CHEMBL2174389) Inhibition of human recombinant HDAC2 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay
ChEMBL_861542 (CHEMBL2174390) Inhibition of human recombinant HDAC1 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay
ChEMBL_1985687 (CHEMBL4619093) Inhibition of recombinant human full length C-terminal His6-tagged LTA4H expressed in Escherichia coli BL21 DE3 cells assessed as reduction in amino-4-methylcoumarin formation using L-arginine-7-amino-4-methylcoumarin as substrate incubated for 30 mins followed by substrate addition and measured for 30 mins by fluorescence based assay
ChEBML_1623659 Inhibition of His-tagged full length recombinant human HDAC8 expressed in baculovirus expression system assessed as release of 7-amino-4-methylcoumarin by fluorogenic assay
ChEMBL_1871620 (CHEMBL4372787) Inhibition of human APN expressed in HEK293 cells preincubated for 20 mins followed by L-leucine-7-amido-4-methylcoumarin addition by fluorescence assay
ChEMBL_2186420 (CHEMBL5098502) Inhibition of DENV2 NS2B-NS3 protease using Boc-Gly-Arg-Arg-7-amino-4-methylcoumarin as substrate incubated for 10 mins by fluorometric assay
ChEMBL_2578973 Inhibition of human HDAC8 using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate incubated for 15 mins by fluorescence plate reader analysis
ChEMBL_321532 (CHEMBL880592) Inhibition against Cytochrome P450 2D6 prepared from baculovirus-infected insect cells using 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy-4-methylcoumarin
ChEMBL_321536 (CHEMBL880596) Inhibition against Cytochrome P450 2D6 prepared from baculovirus-infected insect cells using 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7- methoxy-4-methylcoumarin
ChEMBL_861420 (CHEMBL2174034) Inhibition of human recombinant HDAC3/NCoR2 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay
ChEMBL_976855 (CHEMBL2416379) Inhibition of human recombinant FAAH using N-arachidonyl-7-amino-4-methylcoumarin as substrate preincubated for 20 mins before substrate addition by fluorescence assay
ChEMBL_1438396 (CHEMBL3383625) Inhibition of full length human SIRT1 expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-methylcoumarin (AMC)-labeled peptide by fluorescence assay
ChEMBL_1438397 (CHEMBL3383626) Inhibition of full length human SIRT2 expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-methylcoumarin (AMC)-labeled peptide by fluorescence assay
ChEMBL_1523850 (CHEMBL3632411) Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-7-amino-4-methylcoumarin assessed as substrate hydrolysis measured by fluorescence analysis for 10 mins
ChEMBL_1556916 (CHEMBL3771941) Inhibition of full length human recombinant KDAC1 using fluorophore-conjugated substrate measured as fluorigenic release of 7-amino-4-methylcoumarin by microtiter plate reader analysis
ChEMBL_1556917 (CHEMBL3771942) Inhibition of full length human recombinant KDAC3 using fluorophore-conjugated substrate measured as fluorigenic release of 7-amino-4-methylcoumarin by microtiter plate reader analysis
ChEMBL_1556918 (CHEMBL3771943) Inhibition of full length human recombinant KDAC6 using fluorophore-conjugated substrate measured as fluorigenic release of 7-amino-4-methylcoumarin by microtiter plate reader analysis
ChEMBL_1556919 (CHEMBL3771944) Inhibition of full length human recombinant KDAC8 using fluorophore-conjugated substrate measured as fluorigenic release of 7-amino-4-methylcoumarin by microtiter plate reader analysis
ChEMBL_2223456 (CHEMBL5136790) Inhibition of human full length USP8 overexpressed in baculovirus-infected insect cells using ubiquitin-C-terminal 7-amido-4-methylcoumarin as substrate by fluorescence spectroscopy
ChEMBL_2223457 (CHEMBL5136791) Inhibition of human full length USP7 overexpressed in baculovirus-infected insect cells using ubiquitin-C-terminal 7-amido-4-methylcoumarin as substrate by fluorescence spectroscopy
ChEMBL_2289172 Inhibition of human glutaminyl cyclase using L-glutamine-7-amido-4-methylcoumarin as substrate incubated for 10 mins in presence of pyroglutamyl peptidase by fluorometry analysis
ChEMBL_2322870 Inhibition of human Cathepsin B using Cbz-Phe-Arg-7-amino-4-methylcoumarin as substrate assessed as inhibition constant measured for 10 mins by fluorescence assay
ChEMBL_2578972 Inhibition of HDAC10 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate incubated for 15 mins by fluorescence plate reader analysis
ChEMBL_2578974 Inhibition of HDAC6 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate incubated for 15 mins by fluorescence plate reader analysis
ChEMBL_2578975 Inhibition of HDAC2 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate incubated for 15 mins by fluorescence plate reader analysis
ChEMBL_2578976 Inhibition of HDAC3 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate incubated for 15 mins by fluorescence plate reader analysis
ChEMBL_2578977 Inhibition of HDAC1 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate incubated for 15 mins by fluorescence plate reader analysis
ChEMBL_764466 (CHEMBL1821018) Inhibition of DPP4 in human plasma assessed as formation of 7-amino-4-methylcoumarin from glycyl-L-proline 4-methylcoumaryl-7-amide by fluorescence assay
ChEMBL_880248 (CHEMBL2215826) Inhibition of human recombinant CYP2D6 using 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy- 4-methylcoumarin after 45 mins by fluorescence spectrophotometric analysis
ChEMBL_976846 (CHEMBL2417337) Irreversible inhibition of human recombinant FAAH using N-arachidonyl-7-amino-4-methylcoumarin as substrate preincubated for 60 mins before substrate addition by fluorescence assay
ChEMBL_976849 (CHEMBL2417340) Irreversible inhibition of human recombinant FAAH using N-arachidonyl-7-amino-4-methylcoumarin as substrate preincubated for 20 mins before substrate addition by fluorescence assay
ChEMBL_976850 (CHEMBL2417341) Reversible inhibition of human recombinant FAAH using N-arachidonyl-7-amino-4-methylcoumarin as substrate preincubated for 20 mins before substrate addition by fluorescence assay
ChEMBL_976851 (CHEMBL2417342) Reversible inhibition of human recombinant FAAH using N-arachidonyl-7-amino-4-methylcoumarin as substrate preincubated for 60 mins before substrate addition by fluorescence assay
ChEMBL_1927716 (CHEMBL4430788) Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 60 mins measured every 3 mins by fluorescence assay
ChEMBL_2048967 (CHEMBL4703666) Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluorimetric assay
ChEMBL_2200992 (CHEMBL5113700) Inhibition of HDAC1 (unknown origin) using Boc-Lys(Ac)-7-amino-4-methylcoumarin (BocLys(Ac)-AMC) as substrate incubated for 30 mins by fluorescence based assay
ChEMBL_2200993 (CHEMBL5113701) Inhibition of HDAC6 (unknown origin) using Boc-Lys(Ac)-7-amino-4-methylcoumarin (BocLys(Ac)-AMC) as substrate incubated for 30 mins by fluorescence based assay
ChEMBL_735637 (CHEMBL1693339) Inhibition of Plasmodium falciparum recombinant M1-aminopeptidase expressed in Escherichia coli after 40 mins uisng fluorogenic substrate L-Leucyl-7-amido-40-methylcoumarin by fluorescence spectrophotometry
ChEMBL_988354 (CHEMBL2437617) Inhibition of HDAC3 (unknown origin) using MAZ1600 and MAZ1675 as substrate assessed as fluorogenic release of 7-amino-4-methylcoumarin from substrate by optimized homogenous assay
ChEBML_1623646 Inhibition of C-terminal His/FLAG-tagged full length recombinant human HDAC1 expressed in baculovirus expression system assessed as release of 7-amino-4-methylcoumarin by fluorogenic assay
ChEBML_1699614 Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mins by spectrofluorometry method
ChEBML_1699615 Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mins by spectrofluorometry method
ChEMBL_1808996 (CHEMBL4308355) Inhibition of Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate addition by fluorescence based analysis
ChEMBL_2048968 (CHEMBL4703667) Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluorimetric assay
ChEMBL_2147957 (CHEMBL5032303) Inhibition of HDAC8 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader
ChEMBL_2147958 (CHEMBL5032304) Inhibition of HDAC11 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader
ChEMBL_2147959 (CHEMBL5032305) Inhibition of HDAC10 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader
ChEMBL_2147960 (CHEMBL5032306) Inhibition of HDAC9 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader
ChEMBL_2147961 (CHEMBL5032307) Inhibition of HDAC7 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader
ChEMBL_2147962 (CHEMBL5032308) Inhibition of HDAC4 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader
ChEMBL_2147963 (CHEMBL5032309) Inhibition of HDAC3 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader
ChEMBL_2147964 (CHEMBL5032310) Inhibition of HDAC2 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader
ChEMBL_2147966 (CHEMBL5032312) Inhibition of HDAC5 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader
ChEMBL_2148004 (CHEMBL5032350) Inhibition of HDAC1 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader
ChEMBL_2148005 (CHEMBL5032351) Inhibition of HDAC6 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader
ChEMBL_2476753 Inhibition of USP1/UAF1 complex (unknown origin) using Ub-7-amido-4-methylcoumarin as substrate assessed as inhibition constant incubated for 120 mins by Lineweaver-burk plot analysis
ChEMBL_1505084 (CHEMBL3596003) Inhibition of recombinant full-length HDAC1 (unknown origin) using MAZ1600/MAZ1675 as substrate assessed as release of 7 amino-4-methylcoumarin measured every 5 mins by fluorescence assay
ChEMBL_1505085 (CHEMBL3596004) Inhibition of recombinant full-length HDAC2 (unknown origin) using MAZ1600/MAZ1675 as substrate assessed as release of 7 amino-4-methylcoumarin measured every 5 mins by fluorescence assay
ChEMBL_1505086 (CHEMBL3596005) Inhibition of recombinant full-length HDAC3 (unknown origin) using MAZ1600/MAZ1675 as substrate assessed as release of 7 amino-4-methylcoumarin measured every 5 mins by fluorescence assay
ChEMBL_1505087 (CHEMBL3596006) Inhibition of recombinant full-length HDAC6 (unknown origin) using MAZ1600/MAZ1675 as substrate assessed as release of 7 amino-4-methylcoumarin measured every 5 mins by fluorescence assay
ChEMBL_1505088 (CHEMBL3596007) Inhibition of recombinant full-length HDAC8 (unknown origin) using MAZ1600/MAZ1675 as substrate assessed as release of 7 amino-4-methylcoumarin measured every 5 mins by fluorescence assay
ChEMBL_1505129 (CHEMBL3594645) Inhibition of recombinant human CYP2D6 using 3-[2-(N,N-diethyl-N-methyl amino)-ethyl]-7-methoxy-4-methylcoumarin as substrate after 30 mins by fluorescence-based assay
ChEMBL_1556920 (CHEMBL3771945) Inhibition of human KDAC1 preincubated for 15 mins followed by acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin substrate addition measured after 30 mins by fluorescence assay
ChEMBL_1556976 (CHEMBL3772307) Inhibition of human KDAC3 preincubated for 15 mins followed by acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin substrate addition measured after 30 mins by fluorescence assay
ChEMBL_1556977 (CHEMBL3772308) Inhibition of human KDAC6 preincubated for 15 mins followed by acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin substrate addition measured after 30 mins by fluorescence assay
ChEMBL_1556978 (CHEMBL3772309) Inhibition of human KDAC8 preincubated for 15 mins followed by acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin substrate addition measured after 30 mins by fluorescence assay
ChEMBL_1699614 (CHEMBL4050596) Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mins by spectrofluorometry method
ChEMBL_1699615 (CHEMBL4050597) Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mins by spectrofluorometry method
ChEMBL_1720283 (CHEMBL4135283) Inhibition of C-terminal His-tagged human recombinant full-length HDAC8 expressed in baculovirus expression system assessed as reduction in 7-amino-4-methylcoumarin by fluorescence based assay
ChEMBL_1793165 (CHEMBL4265084) Inhibition of human neutrophil elastase using N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methylcoumarin as substrate measured every 30 secs for 10 mins by fluorescence assay
ChEMBL_1808997 (CHEMBL4308356) Inhibition of Cathepsin L (unknown origin) using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate addition by fluorescence based analysis
ChEMBL_2378195 Inhibition of human neutrophil elastase using N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methylcoumarin as substrate measured every 30 secs for 10 mins by fluorescence based analysis
ChEMBL_879914 (CHEMBL2211908) Inhibition of human recombinant SIRT6 assessed as 7-amino-4-methylcoumarin labelled Arg-His-Lys-Lys(epsilon-acetyl) substrate deacetylation after 90 mins by Fluor-de-Lys assay
ChEMBL_2103470 (CHEMBL4811973) Inhibition Zika virus NS3B (47 to 95 residues)/NS3 (1 to 170 residues) protease expressed in Escherichia coli BL21 using 7-amino-4-methylcoumarin as substrate by fluorescence assay
ChEMBL_2155707 (CHEMBL5040367) Binding affinity to human coagulation factor 9a assessed as inhibition constant using Methylsulfonyl-D-cyclohexylglycyl-glycylarginine 7-amino-4-methylcoumarin as substrate measured upto 120 mins by spectrofluorometric analysis
ChEMBL_1438398 (CHEMBL3383627) Inhibition of catalytically active human SIRT3 (102 to 399 amino acids) expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-methylcoumarin (AMC)-labeled peptide by fluorescence assay
ChEMBL_1517837 (CHEMBL3620528) Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val 7-amido-4-methylcoumarin as substrate preincubated for 15 mins followed by substrate addition measured after 90 mins
ChEMBL_1577038 (CHEMBL3807014) Inhibition of His-tagged human recombinant caspase 7 expressed in Escherichia coli using acetyl-Asp-Glu-Val-Asp-7- amido-4-methylcoumarin (Ac-DEVD-AMC) as substrate by fluorimetric assay
ChEMBL_1577039 (CHEMBL3807015) Inhibition of His-tagged human recombinant caspase 3 expressed in Escherichia coli using acetyl-Asp-Glu-Val-Asp-7- amido-4-methylcoumarin (Ac-DEVD-AMC) as substrate by fluorimetric assay
ChEMBL_1814597 (CHEMBL4314171) Inhibition of recombinant HNE (unknown origin) using N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methylcoumarin, as a substrate measured every 30 sec for 10 mins by fluorometric assay
ChEMBL_1922147 (CHEMBL4424992) Inhibition of recombinant human FAAH using N-arachidonyl-7-amino-4-methylcoumarin as substrate preincubated for 20 mins followed by substrate addition and measured after 30 mins by fluorescence assay
ChEMBL_2023986 (CHEMBL4677799) Inhibition of human neutrophil elastase using N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methylcoumarin as substrate measured for every 30 sec for 10 mins by fluorescence based assay
ChEMBL_2215344 (CHEMBL5128476) Inhibition of FAAH (unknown origin) using 7-amino-4-methylcoumarin-arachidonamide as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence based assay
ChEMBL_306908 (CHEMBL828351) In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 degree C for 60 min
ChEMBL_862400 (CHEMBL2173430) Inhibition of CYP2D6 in human liver microsomes using 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7- methoxy-4-methylcoumarin as substrate after 45 mins by LC/MS/MS analysis
ChEMBL_972954 (CHEMBL2412035) Inhibition of human neutrophil elastase using N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methylcoumarin as substrate measured every 30 seconds for 10 mins by fluorescence microplate reader analysis
ChEMBL_1525147 (CHEMBL3635485) Inhibition of human plasma DPP-4 using Gly-Pro-4-methylcoumaryl-7-amide as substrate assessed as formation of 7-amino-4-methylcoumarin after 2 hrs by fluorescence plate reader analysis
ChEMBL_1577958 (CHEMBL3806657) Inhibition of IgG1 Fc-fused human recombinant BACE1 (1 to 460 residues) expressed in HEK293 cells using methylcoumarin peptide harboring Swedish mutant as substrate incubated for 20 hrs by FRET assay
ChEMBL_1809002 (CHEMBL4308361) Inhibition of Trypanosoma cruzi cruzain assessed as inhibitor constant using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate addition by fluorescence based analysis
ChEMBL_1911029 (CHEMBL4413475) Inhibition of recombinant human CYP2D6 using 3-[2-(N,N-diethylamino)ethyl]-7-methoxy-4-methylcoumarin as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins
ChEMBL_1928377 (CHEMBL4431553) Inhibition of Dengue virus 2 NS2B-NS3 protease expressed in Escherichia coli BL21(DE3) using Boc-Gly-Arg-Arg-7-amino-4-methylcoumarin as substrate after 10 mins by fluorescence assay
ChEMBL_2186447 (CHEMBL5098529) Inhibition of DENV NS2B/NS3 protease transfected in human Huh-7 cells using 7-amino-4-methylcoumarin (AMC) fluorophore-linked peptide substrate Boc-GRR-AMC as substrate by fluoroscence based assay
ChEMBL_1686583 (CHEMBL4037062) Inhibition of HDAC1 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence assay
ChEMBL_1686584 (CHEMBL4037063) Inhibition of HDAC2 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence assay
ChEMBL_1686588 (CHEMBL4037067) Inhibition of HDAC10 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence assay
ChEMBL_1763019 (CHEMBL4198266) Inhibition of HDAC8 (unknown origin) preincubated for 15 mins followed by acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin substrate addition and measured after 30 mins by trypsin coupled fluorescence assay
ChEMBL_1896258 (CHEMBL4398293) Inhibition of His-tagged DENV2 NS2B-NS3 serine protease expressed in Escherichia coli BL21 using Boc-Gly-Arg-Arg-7-amino-4-methylcoumarin as substrate measured after 10 mins by fluorometric assay
ChEMBL_958427 (CHEMBL2382935) Inhibition of human recombinant caspase-7 assessed as Ac-DEVD-AMC conversion to 7-amino-4-methylcoumarin incubated for 10 mins prior to substrate addition measured after 10 mins by spectrophotometric analysis
ChEMBL_958429 (CHEMBL2382937) Inhibition of human recombinant caspase-3 assessed as Ac-DEVD-AMC conversion to 7-amino-4-methylcoumarin incubated for 10 mins prior to substrate addition measured after 10 mins by spectrophotometric analysis
ChEMBL_1896259 (CHEMBL4398294) Inhibition of GST-tagged DENV3 NS2B-NS3 serine protease expressed in Escherichia coli BL21Gold(DE3) using Boc-Gly-Arg-Arg-7-amino-4-methylcoumarin as substrate measured after 10 mins by fluorometric assay
ChEMBL_1930403 (CHEMBL4433654) Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus infected Sf6 insect cells using tertbutyloxycarbonyl (Boc)-(Ac)-Lys-7-amino-4-methylcoumarin as substrate incubated for 1 hr by fluorescence based assay
ChEMBL_2186435 (CHEMBL5098517) Inhibition of DENV2 NS2B-NS3 protease using Boc-Gly-Arg-7-amino-4-methylcoumarin as substrate preincubated for 10 mins followed by substrate addition and incubated for 60 mins by fluorescence spectroscopy assay
ChEMBL_2239730 (CHEMBL5153626) Inhibition of HDAC8 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by fluorescence assay
ChEMBL_1928178 (CHEMBL4431250) Inhibition of HDAC8 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by trypsin-coupled fluorescence assay
ChEMBL_1928188 (CHEMBL4431260) Inhibition of HDAC6 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by trypsin-coupled fluorescence assay
ChEMBL_1928189 (CHEMBL4431261) Inhibition of HDAC1 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by trypsin-coupled fluorescence assay
ChEMBL_2104903 (CHEMBL4813406) Inhibition of N-terminal GST-tagged human recombinant full length HDAC5 expressed in baculovirus-infected Sf9 cells assessed as reduction in 7-amino-4-methylcoumarin release measured every 5 mins by fluorescence based analysis
ChEMBL_2239507 (CHEMBL5153403) Inhibition of human DPP4 expressed in Silkworm baculovirus system preincubated for 30 mins followed by substrate addition and measured after 20 mins using Gly-Pro-4-methylcoumarin-7-amide as substrate by fluorescence assay
ChEMBL_1575271 (CHEMBL3801582) Inhibition of recombinant HDAC8 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by trypsin and substrate addition measured after 30 mins by fluorescence assay
ChEMBL_1908886 (CHEMBL4411244) Inhibition of recombinant human C-terminal His6-tagged S-COMT expressed in 293-6E cells using 7,8-dihydroxy-4-methylcoumarin as substrate and SAM as cofactor incubated for 1 hr by MTase Glo methyltransferase assay
ChEMBL_2104904 (CHEMBL4813407) Inhibition of N-terminal GST-tagged human HDAC7 (518 to end residues) expressed in baculovirus-infected Sf9 cells assessed as reduction in 7-amino-4-methylcoumarin release measured every 5 mins by fluorescence based analysis
ChEMBL_2104905 (CHEMBL4813408) Inhibition of C-terminal His-tagged human HDAC9 (604 to 1066 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction in 7-amino-4-methylcoumarin release measured every 5 mins by fluorescence based analysis
ChEMBL_1699174 (CHEMBL4050156) Inhibition of human DGAT1 expressed in yeast membrane fraction assessed as inhibition of triglyceride formation using diolein/oleoyl-CoA as substrate measured after 1 hr by 7-diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin based fluorescence analysis
ChEMBL_1742587 (CHEMBL4158337) Inhibition of c-terminal hexa-His tagged human S-COMT expressed in HEK293-6E cell membrane homogenate using 7,8-dihydroxy-4-methylcoumarin as substrate after 1 hr in presence of SAM by MTase glo methyltransferase assay
ChEMBL_1742589 (CHEMBL4158339) Inhibition of c-terminal hexa-His tagged rat S-COMT expressed in HEK293-6E cell membrane homogenate using 7,8-dihydroxy-4-methylcoumarin as substrate after 1 hr in presence of SAM by MTase glo methyltransferase assay
ChEMBL_942945 (CHEMBL2343323) Inhibition of N-terminal His6-tagged recombinant TMPRSS4 (unknown origin) fused with enterokinase cleavage sequence DYKDDDGDYKDDDDK expressed in Escherichia coli BL21 (DE3) using Z-Phe-Arg-7-amido-4-methylcoumarin hydrochloride as substrate by fluorometric analysis
Inhibition Assay Cathepsin enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product 7-amino-4-methylcoumarin at 37 C in a stirred cuvette. The wavelengths for excitation and emission were 360nm and 440nm.
ChEMBL_984259 (CHEMBL2432537) Inhibition of human recombinant microsomal CYP2D6 using {3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy-4-methylcoumarin} as substrate assessed as remaining activity at 10 uM after 30 mins by spectrofluorimetric analysis relative to control
ChEMBL_1576875 (CHEMBL3806519) Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human UTMC2 cells assessed as free 7-amino-4-methylcoumarin release preincubated for 22 hrs followed by substrate addition by fluorescent spectrophotometric analysis
ChEMBL_1576927 (CHEMBL3806708) Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human KMH11 cells assessed as free 7-amino-4-methylcoumarin release preincubated for 22 hrs followed by substrate addition by fluorescent spectrophotometric analysis
ChEMBL_1576928 (CHEMBL3806709) Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human KMS18 cells assessed as free 7-amino-4-methylcoumarin release preincubated for 22 hrs followed by substrate addition by fluorescent spectrophotometric analysis
ChEMBL_1576930 (CHEMBL3806711) Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human NB4 cells assessed as free 7-amino-4-methylcoumarin release preincubated for 22 hrs followed by substrate addition by fluorescent spectrophotometric analysis
ChEMBL_1576931 (CHEMBL3806712) Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human KG1A cells assessed as free 7-amino-4-methylcoumarin release preincubated for 22 hrs followed by substrate addition by fluorescent spectrophotometric analysis
ChEMBL_1576933 (CHEMBL3806714) Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human K562 cells assessed as free 7-amino-4-methylcoumarin release preincubated for 22 hrs followed by substrate addition by fluorescent spectrophotometric analysis
ChEMBL_1842102 (CHEMBL4342529) Inhibition of cathepsin B (unknown origin) assessed as reduction in 7-amino-4-methylcoumarin formation using Z-Arg-Arg-MCA as substrate preincubated for 3 mins followed by substrate addition and measured after 10 mins by fluorescence spectrometric method
ChEMBL_2104900 (CHEMBL4813403) Inhibition of C-terminal 6XHis-tagged human recombinant full length HDAC2 (1 to 488 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction in 7-amino-4-methylcoumarin release measured every 5 mins by fluorescence based analysis
ChEMBL_2233284 (CHEMBL5147056) Inhibition of epimastigote form of Trypanosoma cruzi Tulahuen 2 cruzain assessed as reduction in 7-amino-4-methylcoumarin release incubated for 20 mins folllowed by Z-FR-AMC substrate addition and measured up to 45 mins by fluorometric assay
ChEMBL_1576929 (CHEMBL3806710) Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human OCI-AML2 cells assessed as free 7-amino-4-methylcoumarin release preincubated for 22 hrs followed by substrate addition by fluorescent spectrophotometric analysis
ChEMBL_1576932 (CHEMBL3806713) Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human MDAY-D2 cells assessed as free 7-amino-4-methylcoumarin release preincubated for 22 hrs followed by substrate addition by fluorescent spectrophotometric analysis
ChEMBL_1838450 (CHEMBL4338583) Inhibition of N-terminal hexa-histidine tagged Zika virus NS2B/NS3 protease expressed in Escherichia coli BL21-Gold (DE3) using fluorogenic AMC-substituted peptide boc-GRR-7-amino-4-methylcoumarin measured every 30 secs for 10 mins by fluorometric assay
ChEMBL_1985684 (CHEMBL4619090) Inhibition of recombinant human C-terminal His6-tagged LTA4H expressed in Escherichia coli BL21 DE3 cells using 7-amido-4-methylcoumarin as substrate incubated for 30 mins followed by substrate addition and measured for 30 mins by fluorescence based assay
ChEMBL_2104902 (CHEMBL4813405) Inhibition of N-terminal GST-tagged/C-terminal His-tagged human recombinant HDAC4 (627 to 1084 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction in 7-amino-4-methylcoumarin release measured every 5 mins by fluorescence based analysis
ChEMBL_960984 (CHEMBL2388900) Inhibition of rat FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin preincubated for 15 mins prior to substrate addition measured after 1 to 3 hrs by fluorescence assay
ChEMBL_960986 (CHEMBL2388902) Inhibition of human FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin preincubated for 15 mins prior to substrate addition measured after 1 to 3 hrs by fluorescence assay
ChEMBL_2051502 (CHEMBL4706201) Inhibition of human liver Cathepsin D using N-succinyl-R-P-F-L-L-V-Y-7-amido-4-methylcoumarin peptide as substrate preincubated for 10 mins followed by substrate addition and further incubated for 45 mins by Cyto-fluor fluorescence analysis
ChEMBL_2104899 (CHEMBL4813402) Inhibition of C-terminal FLAG/His-tagged human recombinant HDAC1 (1 to 482 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction in 7-amino-4-methylcoumarin release using fluorogenic HDAC substrate 3 measured every 5 mins by fluorescence based analysis
ChEMBL_2171278 (CHEMBL5056412) Inhibition of human recombinant CYP2D6 expressed in insect microsome using (3-[2-(N,N-dimethyl-N-methylammonium)-ethyl]-7-methoxy-4-methylcoumarin iodide as a substrate incubated for 30 mins followed by addition of NADPH regenerating system measured immediately by fluorescence based analysis
ChEMBL_2440388 Inhibition of full length wild type human USP7 expressed in Sf9 cells using Bac-to-Bac Baculovirus system by using ubiquitin-7-amido-4-methylcoumarin as substrate preincubated for 30 mins followed by substrate addition and measured after 1 hr by fluorescence based analysis
ChEMBL_1838455 (CHEMBL4338588) Non-competitive inhibition of N-terminal hexa-histidine tagged Zika virus NS2B/NS3 protease expressed in Escherichia coli BL21-Gold (DE3) using 50 to 200 uM fluorogenic AMC-substituted peptide boc-GRR-7-amino-4-methylcoumarin measured every 30 secs for 10 mins by fluorometric assay based Dixon plot analysis
ChEMBL_2104901 (CHEMBL4813404) Inhibition of C-terminal His-tagged human recombinant full length HDAC3 (1 to 428 residues)/N-terminal GST-tagged human recombinant NCOR2 (395 to 489 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction in 7-amino-4-methylcoumarin release using fluorogenic HDAC substrate 3 measured every 5 mins by fluorescence based analysis