Compile Data Set for Download or QSAR
Report error Found 60 Enz. Inhib. hit(s) with all data for entry = 50031418
LigandChemical structure of BindingDB Monomer ID 50312752BDBM50312752((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312922BDBM50312922((S)-N1-(5-(isoquinolin-6-yl)thiazol-2-yl)-3-(4-(tr...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312934BDBM50312934((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312931BDBM50312931((S)-N1-(5-(1H-indazol-5-yl)thiazol-2-yl)-3-(4-(tri...)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312942BDBM50312942((S)-N1-(5-(3-aminoisoquinolin-6-yl)thiazol-2-yl)-3...)
Affinity DataIC50: 12nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312922BDBM50312922((S)-N1-(5-(isoquinolin-6-yl)thiazol-2-yl)-3-(4-(tr...)
Affinity DataIC50: 12nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312942BDBM50312942((S)-N1-(5-(3-aminoisoquinolin-6-yl)thiazol-2-yl)-3...)
Affinity DataIC50: 15nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312936BDBM50312936((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312924BDBM50312924((S)-N1-(3-(isoquinolin-6-yl)isoxazol-5-yl)-3-(4-(t...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312933BDBM50312933((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312935BDBM50312935((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312943BDBM50312943((S)-N1-(5-(quinazolin-7-yl)thiazol-2-yl)-3-(4-(tri...)
Affinity DataIC50: 35nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312925BDBM50312925((R)-4-(3-(isoquinolin-6-yl)isoxazol-5-yl)-1-(4-(tr...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312752BDBM50312752((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)
Affinity DataIC50: 53nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312932BDBM50312932((S)-N1-(5-(1-amino-1H-benzo[d][1,2,3]triazol-6-yl)...)
Affinity DataIC50: 55nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312932BDBM50312932((S)-N1-(5-(1-amino-1H-benzo[d][1,2,3]triazol-6-yl)...)
Affinity DataIC50: 77nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312941BDBM50312941((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-oxadiazol-2-yl)...)
Affinity DataIC50: 85nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312924BDBM50312924((S)-N1-(3-(isoquinolin-6-yl)isoxazol-5-yl)-3-(4-(t...)
Affinity DataIC50: 93nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312940BDBM50312940((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 95nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312933BDBM50312933((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 110nMAssay Description:Inhibition of cKITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312925BDBM50312925((R)-4-(3-(isoquinolin-6-yl)isoxazol-5-yl)-1-(4-(tr...)
Affinity DataIC50: 117nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312943BDBM50312943((S)-N1-(5-(quinazolin-7-yl)thiazol-2-yl)-3-(4-(tri...)
Affinity DataIC50: 136nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312934BDBM50312934((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 138nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312944BDBM50312944((S)-N1-(5-(cinnolin-6-yl)thiazol-2-yl)-3-(4-(trifl...)
Affinity DataIC50: 141nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312933BDBM50312933((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 185nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312933BDBM50312933((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 250nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312752BDBM50312752((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)
Affinity DataIC50: 250nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312936BDBM50312936((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 276nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312935BDBM50312935((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 285nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312933BDBM50312933((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 300nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312933BDBM50312933((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312941BDBM50312941((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-oxadiazol-2-yl)...)
Affinity DataIC50: 348nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312923BDBM50312923((S)-N1-(2-(isoquinolin-6-yl)thiazol-5-yl)-3-(4-(tr...)
Affinity DataIC50: 404nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312922BDBM50312922((S)-N1-(5-(isoquinolin-6-yl)thiazol-2-yl)-3-(4-(tr...)
Affinity DataIC50: 430nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312930BDBM50312930((S)-N1-(5-(3-aminobenzo[d]isoxazol-5-yl)thiazol-2-...)
Affinity DataIC50: 453nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312934BDBM50312934((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312927BDBM50312927((S)-N1-(5-(1H-indazol-6-yl)thiazol-2-yl)-3-(4-(tri...)
Affinity DataIC50: 613nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312936BDBM50312936((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 630nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312931BDBM50312931((S)-N1-(5-(1H-indazol-5-yl)thiazol-2-yl)-3-(4-(tri...)
Affinity DataIC50: 730nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312942BDBM50312942((S)-N1-(5-(3-aminoisoquinolin-6-yl)thiazol-2-yl)-3...)
Affinity DataIC50: 890nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312928BDBM50312928((S)-N1-(5-(1-methyl-1H-indazol-6-yl)thiazol-2-yl)-...)
Affinity DataIC50: 895nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312935BDBM50312935((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 920nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312938BDBM50312938((S)-7-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312938BDBM50312938((S)-7-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312927BDBM50312927((S)-N1-(5-(1H-indazol-6-yl)thiazol-2-yl)-3-(4-(tri...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312923BDBM50312923((S)-N1-(2-(isoquinolin-6-yl)thiazol-5-yl)-3-(4-(tr...)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312943BDBM50312943((S)-N1-(5-(quinazolin-7-yl)thiazol-2-yl)-3-(4-(tri...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50312926BDBM50312926((R)-4-(3-(isoquinolin-6-yl)-1,2,4-oxadiazol-5-yl)-...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312930BDBM50312930((S)-N1-(5-(3-aminobenzo[d]isoxazol-5-yl)thiazol-2-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50312944BDBM50312944((S)-N1-(5-(cinnolin-6-yl)thiazol-2-yl)-3-(4-(trifl...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
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