BindingDB logo
myBDB logout

Patent code US11034692

Compile Data Set for Download or QSAR

Found 420 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503940
PNG
(1-(3-(4-(8-amino-6-(4-methylpyridin-3- yl)-2,7-nap...)
Show SMILES CC(=O)N1CC[C@@H](C1)n1cc(Nc2cc3cc(nc(N)c3cn2)-c2cnccc2C)cn1
Show InChI InChI=1S/C23H24N8O/c1-14-3-5-25-10-19(14)21-7-16-8-22(26-11-20(16)23(24)29-21)28-17-9-27-31(12-17)18-4-6-30(13-18)15(2)32/h3,5,7-12,18H,4,6,13H2,1-2H3,(H2,24,29)(H,26,28)/t18-/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503988
PNG
(2-[[8-amino-6-(4-methylpyridin-3-yl)-2,7- naphthyr...)
Show SMILES CN1CCc2cc(Nc3cc4cc(nc(N)c4cn3)-c3cnccc3C)nn2CC1=O
Show InChI InChI=1S/C22H22N8O/c1-13-3-5-24-10-16(13)18-7-14-8-19(25-11-17(14)22(23)26-18)27-20-9-15-4-6-29(2)21(31)12-30(15)28-20/h3,5,7-11H,4,6,12H2,1-2H3,(H2,23,26)(H,25,27,28)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504062
PNG
((1R,2R)-N-(8-amino-6-(4-methylpyridin- 3-yl)-2,7-n...)
Show SMILES COCCn1cc(cn1)[C@@H]1C[C@H]1C(=O)Nc1cc2cc(nc(N)c2cn1)-c1cnccc1C
Show InChI InChI=1S/C24H25N7O2/c1-14-3-4-26-11-19(14)21-7-15-8-22(27-12-20(15)23(25)29-21)30-24(32)18-9-17(18)16-10-28-31(13-16)5-6-33-2/h3-4,7-8,10-13,17-18H,5-6,9H2,1-2H3,(H2,25,29)(H,27,30,32)/t17-,18+/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
<0.0200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504051
PNG
((1S,2S)—N-(8-amino-6-(4-methyl-2-phenylpyridi...)
Show SMILES Cc1ccnc(-c2ccccc2)c1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3c3cnn(C)c3)ncc2c(N)n1
Show InChI InChI=1S/C28H25N7O/c1-16-8-9-30-26(17-6-4-3-5-7-17)25(16)23-10-18-11-24(31-14-22(18)27(29)33-23)34-28(36)21-12-20(21)19-13-32-35(2)15-19/h3-11,13-15,20-21H,12H2,1-2H3,(H2,29,33)(H,31,34,36)/t20-,21+/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503914
PNG
((1S,2S)-N-(8-amino-5-fluoro-6-(4- methylpyridin-3-...)
Show SMILES Cc1ccncc1-c1nc(N)c2cnc(NC(=O)[C@H]3C[C@@H]3c3cn[nH]c3)cc2c1F
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503879
PNG
(1-[3-[4-[[8-amino-6-(4-methyl-3-pyridyl)- 2,7-naph...)
Show SMILES CC(=O)N1CC(C1)n1cc(Nc2cc3cc(nc(N)c3cn2)-c2cnccc2C)cn1
Show InChI InChI=1S/C22H22N8O/c1-13-3-4-24-8-18(13)20-5-15-6-21(25-9-19(15)22(23)28-20)27-16-7-26-30(10-16)17-11-29(12-17)14(2)31/h3-10,17H,11-12H2,1-2H3,(H2,23,28)(H,25,27)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504049
PNG
((1R,2S)—N-(8-amino-5-cyclopropyl-6-(4-methylp...)
Show SMILES Cc1ccncc1-c1nc(N)c2cnc(NC(=O)[C@H]3C[C@@H]3CC#N)cc2c1C1CC1
Show InChI InChI=1S/C23H22N6O/c1-12-5-7-26-10-17(12)21-20(13-2-3-13)16-9-19(27-11-18(16)22(25)29-21)28-23(30)15-8-14(15)4-6-24/h5,7,9-11,13-15H,2-4,8H2,1H3,(H2,25,29)(H,27,28,30)/t14-,15-/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504044
PNG
(US11034692, Compound 313)
Show SMILES Cc1ccncc1-c1cc2cc(NC(=O)[C@H]3C[C@]33CCNC(=O)C3)ncc2c(N)n1
Show InChI InChI=1S/C22H22N6O2/c1-12-2-4-24-10-14(12)17-6-13-7-18(26-11-15(13)20(23)27-17)28-21(30)16-8-22(16)3-5-25-19(29)9-22/h2,4,6-7,10-11,16H,3,5,8-9H2,1H3,(H2,23,27)(H,25,29)(H,26,28,30)/t16-,22+/m1/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503863
PNG
(US11034692, Compound 146 | trans-N-[8-amino-6-(4-m...)
Show SMILES CCS(=O)(=O)n1cc(cn1)[C@@H]1C[C@H]1C(=O)Nc1cc2cc(nc(N)c2cn1)-c1cnccc1C
Show InChI InChI=1S/C23H23N7O3S/c1-3-34(32,33)30-12-15(9-27-30)16-8-17(16)23(31)29-21-7-14-6-20(18-10-25-5-4-13(18)2)28-22(24)19(14)11-26-21/h4-7,9-12,16-17H,3,8H2,1-2H3,(H2,24,28)(H,26,29,31)/t16-,17+/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503999
PNG
(3-[[8-Amino-6-(4-methylpyridin-3-yl)-2,7- naphthyr...)
Show SMILES CNC(=O)c1cc(Nc2cc3cc(nc(N)c3cn2)-c2cnccc2C)nn1C
Show InChI InChI=1S/C20H20N8O/c1-11-4-5-23-9-13(11)15-6-12-7-17(24-10-14(12)19(21)25-15)26-18-8-16(20(29)22-2)28(3)27-18/h4-10H,1-3H3,(H2,21,25)(H,22,29)(H,24,26,27)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0210n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503978
PNG
(US11034692, Compound 247)
Show SMILES Cc1c(N)cncc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3CC#N)ncc2c(N)n1
Show InChI InChI=1S/C20H19N7O/c1-10-14(7-24-9-16(10)22)17-5-12-6-18(25-8-15(12)19(23)26-17)27-20(28)13-4-11(13)2-3-21/h5-9,11,13H,2,4,22H2,1H3,(H2,23,26)(H,25,27,28)/t11-,13-/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0220n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504027
PNG
((1S,2S)—N-[8-amino-6-(2,6-dichlorophenyl)-2,7...)
Show SMILES NCCOCCn1cc(cn1)[C@@H]1C[C@H]1C(=O)Nc1cc2cc(nc(N)c2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C25H25Cl2N7O2/c26-19-2-1-3-20(27)23(19)21-8-14-9-22(30-12-18(14)24(29)32-21)33-25(35)17-10-16(17)15-11-31-34(13-15)5-7-36-6-4-28/h1-3,8-9,11-13,16-17H,4-7,10,28H2,(H2,29,32)(H,30,33,35)/t16-,17+/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0260n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503943
PNG
(1-(3-(8-amino-6-(4-methylpyridin-3-yl)- 2,7-naphth...)
Show SMILES C[C@@H](O)c1cc(Nc2cc3cc(nc(N)c3cn2)-c2cnccc2C)nn1C
Show InChI InChI=1S/C20H21N7O/c1-11-4-5-22-9-14(11)16-6-13-7-18(23-10-15(13)20(21)24-16)25-19-8-17(12(2)28)27(3)26-19/h4-10,12,28H,1-3H3,(H2,21,24)(H,23,25,26)/t12-/m1/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0260n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503916
PNG
((1S,2S)-N-(8-amino-6-(4-methylpyridin-3- yl)-2,7-n...)
Show SMILES Cc1ccncc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3c3cnn(C)c3)ncc2c(N)n1
Show InChI InChI=1S/C22H21N7O/c1-12-3-4-24-9-17(12)19-5-13-6-20(25-10-18(13)21(23)27-19)28-22(30)16-7-15(16)14-8-26-29(2)11-14/h3-6,8-11,15-16H,7H2,1-2H3,(H2,23,27)(H,25,28,30)/t15-,16+/m1/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0270n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504034
PNG
((1R,2R)—N-(8-amino-6-(2-chloro-6-fluorophenyl...)
Show SMILES Cn1cc(cn1)[C@H]1C[C@@H]1C(=O)Nc1cc2cc(nc(N)c2cn1)-c1c(F)cccc1Cl
Show InChI InChI=1S/C22H18ClFN6O/c1-30-10-12(8-27-30)13-7-14(13)22(31)29-19-6-11-5-18(28-21(25)15(11)9-26-19)20-16(23)3-2-4-17(20)24/h2-6,8-10,13-14H,7H2,1H3,(H2,25,28)(H,26,29,31)/t13-,14+/m1/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0270n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504050
PNG
(US11034692, Compound 318)
Show SMILES Cc1ccnc(-c2ccccc2)c1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3c3cnn(C)c3)ncc2c(N)n1
Show InChI InChI=1S/C28H25N7O/c1-16-8-9-30-26(17-6-4-3-5-7-17)25(16)23-10-18-11-24(31-14-22(18)27(29)33-23)34-28(36)21-12-20(21)19-13-32-35(2)15-19/h3-11,13-15,20-21H,12H2,1-2H3,(H2,29,33)(H,31,34,36)/t20-,21+/m1/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0320n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504030
PNG
((1R,2R)—N-[8-amino-6-(2-methylphenyl)-2,7-nap...)
Show SMILES Cc1ccccc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3c3cnn(C)c3)ncc2c(N)n1
Show InChI InChI=1S/C23H22N6O/c1-13-5-3-4-6-16(13)20-7-14-8-21(25-11-19(14)22(24)27-20)28-23(30)18-9-17(18)15-10-26-29(2)12-15/h3-8,10-12,17-18H,9H2,1-2H3,(H2,24,27)(H,25,28,30)/t17-,18+/m1/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0360n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503936
PNG
(US11034692, Compound 214)
Show SMILES Cn1cc(cn1)[C@@H]1C[C@H]1C(=O)Nc1cc2cc(nc(N)c2cn1)-c1cnccc1CCO
Show InChI InChI=1S/C23H23N7O2/c1-30-12-15(9-27-30)16-8-17(16)23(32)29-21-7-14-6-20(28-22(24)19(14)11-26-21)18-10-25-4-2-13(18)3-5-31/h2,4,6-7,9-12,16-17,31H,3,5,8H2,1H3,(H2,24,28)(H,26,29,32)/t16-,17+/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0390n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504023
PNG
(US11034692, Compound 292)
Show SMILES Cc1ccncc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3c3cnn(CCOCCN)c3)ncc2c(N)n1
Show InChI InChI=1S/C25H28N8O2/c1-15-2-4-28-12-20(15)22-8-16-9-23(29-13-21(16)24(27)31-22)32-25(34)19-10-18(19)17-11-30-33(14-17)5-7-35-6-3-26/h2,4,8-9,11-14,18-19H,3,5-7,10,26H2,1H3,(H2,27,31)(H,29,32,34)/t18-,19+/m1/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0420n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503977
PNG
((1S,2S)—N-(8-amino-6-(4-(2-hydroxyethyl)pyrid...)
Show SMILES Nc1nc(cc2cc(NC(=O)[C@@H]3C[C@H]3c3cnsc3)ncc12)-c1cnccc1CCO
Show InChI InChI=1S/C22H20N6O2S/c23-21-18-10-25-20(28-22(30)16-7-15(16)14-8-26-31-11-14)6-13(18)5-19(27-21)17-9-24-3-1-12(17)2-4-29/h1,3,5-6,8-11,15-16,29H,2,4,7H2,(H2,23,27)(H,25,28,30)/t15-,16+/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0450n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503892
PNG
(US11034692, Compound 173 | trans-N-(8-amino-5-chlo...)
Show SMILES Cc1ccncc1-c1nc(N)c2cnc(NC(=O)[C@@H]3C[C@H]3c3cn[nH]c3)cc2c1Cl
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0470n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503926
PNG
(US11034692, Compound 206 | trans-N-(8-amino-6-(4-m...)
Show SMILES Cc1ccnc(-c2ccccc2)c1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3CC#N)ncc2c(N)n1
Show InChI InChI=1S/C26H22N6O/c1-15-8-10-29-24(16-5-3-2-4-6-16)23(15)21-12-18-13-22(30-14-20(18)25(28)31-21)32-26(33)19-11-17(19)7-9-27/h2-6,8,10,12-14,17,19H,7,11H2,1H3,(H2,28,31)(H,30,32,33)/t17-,19-/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0510n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503939
PNG
(2-(4-(8-amino-6-(4-methylpyridin-3-yl)- 2,7-naphth...)
Show SMILES CC(C#N)n1cc(Nc2cc3cc(nc(N)c3cn2)-c2cnccc2C)cn1
Show InChI InChI=1S/C20H18N8/c1-12-3-4-23-9-16(12)18-5-14-6-19(24-10-17(14)20(22)27-18)26-15-8-25-28(11-15)13(2)7-21/h3-6,8-11,13H,1-2H3,(H2,22,27)(H,24,26)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0610n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503839
PNG
(US11034692, Compound 122 | trans-N-[8-amino-6-(4-m...)
Show SMILES Cc1ccncc1-c1cc2cc(NC(=O)C3C[C@@H]3c3cn[nH]c3)ncc2c(N)n1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0630n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504009
PNG
((R)-2-(4-(8-amino-6-(4-methylpyridin-3- yl)-2,7-na...)
Show SMILES C[C@H](C#N)n1cc(Nc2cc3cc(nc(N)c3cn2)-c2cnccc2C)cn1
Show InChI InChI=1S/C20H18N8/c1-12-3-4-23-9-16(12)18-5-14-6-19(24-10-17(14)20(22)27-18)26-15-8-25-28(11-15)13(2)7-21/h3-6,8-11,13H,1-2H3,(H2,22,27)(H,24,26)/t13-/m1/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0680n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504041
PNG
(US11034692, Compound 310)
Show SMILES Nc1nc(cc2cc(NC(=O)[C@H]3C[C@@H]3CC#N)ncc12)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C20H15Cl2N5O/c21-14-2-1-3-15(22)18(14)16-7-11-8-17(25-9-13(11)19(24)26-16)27-20(28)12-6-10(12)4-5-23/h1-3,7-10,12H,4,6H2,(H2,24,26)(H,25,27,28)/t10-,12-/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0680n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504032
PNG
((1R,2R)—N-[8-amino-6-(5-cyano-2-methylphenyl)...)
Show SMILES Cc1ccc(cc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3c3cnn(C)c3)ncc2c(N)n1)C#N
Show InChI InChI=1S/C24H21N7O/c1-13-3-4-14(9-25)5-17(13)21-6-15-7-22(27-11-20(15)23(26)29-21)30-24(32)19-8-18(19)16-10-28-31(2)12-16/h3-7,10-12,18-19H,8H2,1-2H3,(H2,26,29)(H,27,30,32)/t18-,19+/m1/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0690n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504058
PNG
(US11034692, Compound 326)
Show SMILES C[C@@H]1[C@H]([C@@H]1c1cnn(C)c1)C(=O)Nc1cc2cc(nc(N)c2cn1)-c1cnccc1C
Show InChI InChI=1S/C23H23N7O/c1-12-4-5-25-9-16(12)18-6-14-7-19(26-10-17(14)22(24)28-18)29-23(31)21-13(2)20(21)15-8-27-30(3)11-15/h4-11,13,20-21H,1-3H3,(H2,24,28)(H,26,29,31)/t13-,20-,21+/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0740n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503960
PNG
((1S,2S)—N-(8-amino-5-chloro-6-(4-methylpyridi...)
Show SMILES Cc1ccncc1-c1nc(N)c2cnc(NC(=O)[C@@H]3C[C@H]3c3cnn(C)c3)cc2c1Cl
Show InChI InChI=1S/C22H20ClN7O/c1-11-3-4-25-8-16(11)20-19(23)14-6-18(26-9-17(14)21(24)29-20)28-22(31)15-5-13(15)12-7-27-30(2)10-12/h3-4,6-10,13,15H,5H2,1-2H3,(H2,24,29)(H,26,28,31)/t13-,15+/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0780n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504017
PNG
((1R,2R)-N-[8-amino-6-(5-hydroxy-2- methylphenyl)-2...)
Show SMILES Cc1ccc(O)cc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3c3cnn(C)c3)ncc2c(N)n1
Show InChI InChI=1S/C23H22N6O2/c1-12-3-4-15(30)7-16(12)20-5-13-6-21(25-10-19(13)22(24)27-20)28-23(31)18-8-17(18)14-9-26-29(2)11-14/h3-7,9-11,17-18,30H,8H2,1-2H3,(H2,24,27)(H,25,28,31)/t17-,18+/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0780n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503925
PNG
(US11034692, Compound 205 | trans-N-(8-amino-5-meth...)
Show SMILES Cc1ccncc1-c1nc(N)c2cnc(NC(=O)[C@H]3C[C@@H]3CC#N)cc2c1C
Show InChI InChI=1S/C21H20N6O/c1-11-4-6-24-9-16(11)19-12(2)14-8-18(25-10-17(14)20(23)27-19)26-21(28)15-7-13(15)3-5-22/h4,6,8-10,13,15H,3,7H2,1-2H3,(H2,23,27)(H,25,26,28)/t13-,15-/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0880n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503985
PNG
(US11034692, Compound 253)
Show SMILES Nc1nc(cc2cc(NC(=O)[C@@H]3C[C@H]3c3cccnc3)ncc12)-c1cnccc1CCO
Show InChI InChI=1S/C24H22N6O2/c25-23-20-13-28-22(30-24(32)18-10-17(18)15-2-1-5-26-11-15)9-16(20)8-21(29-23)19-12-27-6-3-14(19)4-7-31/h1-3,5-6,8-9,11-13,17-18,31H,4,7,10H2,(H2,25,29)(H,28,30,32)/t17-,18+/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.0890n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503795
PNG
(3-(4-Ethylpyridin-3-yl)-N6-(1-piperidin-4- yl-1H-p...)
Show SMILES CCc1ccncc1-c1cc2cc(Nc3cnn(c3)C3CCNCC3)ncc2c(N)n1
Show InChI InChI=1S/C23H26N8/c1-2-15-3-6-26-12-19(15)21-9-16-10-22(27-13-20(16)23(24)30-21)29-17-11-28-31(14-17)18-4-7-25-8-5-18/h3,6,9-14,18,25H,2,4-5,7-8H2,1H3,(H2,24,30)(H,27,29)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504038
PNG
((1S,2S)—N-[8-amino-6-(2,6-difluorophenyl)-2,7...)
Show SMILES Cn1cc(cn1)[C@H]1C[C@@H]1C(=O)Nc1cc2cc(nc(N)c2cn1)-c1c(F)cccc1F
Show InChI InChI=1S/C22H18F2N6O/c1-30-10-12(8-27-30)13-7-14(13)22(31)29-19-6-11-5-18(28-21(25)15(11)9-26-19)20-16(23)3-2-4-17(20)24/h2-6,8-10,13-14H,7H2,1H3,(H2,25,28)(H,26,29,31)/t13-,14+/m1/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.112n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504003
PNG
(US11034692, Compound 267 | trans-N-(8-amino-6-(5-f...)
Show SMILES Cc1ccc(F)cc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3c3cnn(C)c3)ncc2c(N)n1
Show InChI InChI=1S/C23H21FN6O/c1-12-3-4-15(24)7-16(12)20-5-13-6-21(26-10-19(13)22(25)28-20)29-23(31)18-8-17(18)14-9-27-30(2)11-14/h3-7,9-11,17-18H,8H2,1-2H3,(H2,25,28)(H,26,29,31)/t17-,18+/m1/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.113n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504060
PNG
(US11034692, Compound 328)
Show SMILES C[C@@H]1[C@@H]([C@H]1c1cnn(C)c1)C(=O)Nc1cc2cc(nc(N)c2cn1)-c1cnccc1C
Show InChI InChI=1S/C23H23N7O/c1-12-4-5-25-9-16(12)18-6-14-7-19(26-10-17(14)22(24)28-18)29-23(31)21-13(2)20(21)15-8-27-30(3)11-15/h4-11,13,20-21H,1-3H3,(H2,24,28)(H,26,29,31)/t13-,20+,21-/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.114n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504006
PNG
((1R,2S)—N-[8-amino-5-chloro-6-(4-methylpyridi...)
Show SMILES Cc1ccncc1-c1nc(N)c2cnc(NC(=O)[C@H]3C[C@@H]3CC#N)cc2c1Cl
Show InChI InChI=1S/C20H17ClN6O/c1-10-3-5-24-8-14(10)18-17(21)13-7-16(25-9-15(13)19(23)27-18)26-20(28)12-6-11(12)2-4-22/h3,5,7-9,11-12H,2,6H2,1H3,(H2,23,27)(H,25,26,28)/t11-,12-/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.116n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504002
PNG
(2-(4-[[8-amino-6-(4-methylpyridin-3-yl)- 2,7-napht...)
Show SMILES Cc1ccncc1-c1cc2cc(Nc3cnn(c3)C(C)(C)CO)ncc2c(N)n1
Show InChI InChI=1S/C21H23N7O/c1-13-4-5-23-9-16(13)18-6-14-7-19(24-10-17(14)20(22)27-18)26-15-8-25-28(11-15)21(2,3)12-29/h4-11,29H,12H2,1-3H3,(H2,22,27)(H,24,26)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.118n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504000
PNG
((4-[[8-Amino-6-(4-methylpyridin-3-yl-2,7- naphthyr...)
Show SMILES Cc1ccncc1-c1cc2cc(Nc3ccc(CS(N)(=O)=O)cc3)ncc2c(N)n1
Show InChI InChI=1S/C21H20N6O2S/c1-13-6-7-24-10-17(13)19-8-15-9-20(25-11-18(15)21(22)27-19)26-16-4-2-14(3-5-16)12-30(23,28)29/h2-11H,12H2,1H3,(H2,22,27)(H,25,26)(H2,23,28,29)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.134n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503945
PNG
(US11034692, Compound 223 | cis-N-(8-amino-6-(3,4-d...)
Show SMILES Nc1nc(cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc12)-c1cncc2NCCOc12
Show InChI InChI=1S/C19H17FN6O2/c20-13-5-10(13)19(27)26-16-4-9-3-14(25-18(21)11(9)7-24-16)12-6-22-8-15-17(12)28-2-1-23-15/h3-4,6-8,10,13,23H,1-2,5H2,(H2,21,25)(H,24,26,27)/t10-,13+/m1/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.135n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503874
PNG
(US11034692, Compound 157 | US11034692, Compound 19...)
Show SMILES Cc1ccncc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3CC#N)ncc2c(N)n1
Show InChI InChI=1S/C20H18N6O/c1-11-3-5-23-9-15(11)17-7-13-8-18(24-10-16(13)19(22)25-17)26-20(27)14-6-12(14)2-4-21/h3,5,7-10,12,14H,2,6H2,1H3,(H2,22,25)(H,24,26,27)/t12-,14-/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.135n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504008
PNG
((1R,2S)—N-[8-amino-5-ethyl-6-(4-methylpyridin...)
Show SMILES CCc1c(nc(N)c2cnc(NC(=O)[C@@H]3C[C@H]3CC#N)cc12)-c1cnccc1C
Show InChI InChI=1S/C22H22N6O/c1-3-14-16-9-19(27-22(29)15-8-13(15)4-6-23)26-11-18(16)21(24)28-20(14)17-10-25-7-5-12(17)2/h5,7,9-11,13,15H,3-4,8H2,1-2H3,(H2,24,28)(H,26,27,29)/t13-,15-/m1/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.139n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504004
PNG
(US11034692, Compound 268 | trans-N-[8-amino-6-(5-h...)
Show SMILES Cc1ccc(O)cc1-c1cc2cc(NC(=O)C3CC3c3cnn(C)c3)ncc2c(N)n1
Show InChI InChI=1S/C23H22N6O2/c1-12-3-4-15(30)7-16(12)20-5-13-6-21(25-10-19(13)22(24)27-20)28-23(31)18-8-17(18)14-9-26-29(2)11-14/h3-7,9-11,17-18,30H,8H2,1-2H3,(H2,24,27)(H,25,28,31)
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.147n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503869
PNG
(US11034692, Compound 152 | trans-N-[8-amino-6-(4-m...)
Show SMILES Cc1ccncc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3c3cnsc3)ncc2c(N)n1
Show InChI InChI=1S/C21H18N6OS/c1-11-2-3-23-8-16(11)18-4-12-5-19(24-9-17(12)20(22)26-18)27-21(28)15-6-14(15)13-7-25-29-10-13/h2-5,7-10,14-15H,6H2,1H3,(H2,22,26)(H,24,27,28)/t14-,15+/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.150n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504036
PNG
((1S,2S)—N-[8-amino-6-(2-chlorophenyl)-2,7-nap...)
Show SMILES Cn1cc(cn1)[C@H]1C[C@@H]1C(=O)Nc1cc2cc(nc(N)c2cn1)-c1ccccc1Cl
Show InChI InChI=1S/C22H19ClN6O/c1-29-11-13(9-26-29)15-8-16(15)22(30)28-20-7-12-6-19(14-4-2-3-5-18(14)23)27-21(24)17(12)10-25-20/h2-7,9-11,15-16H,8H2,1H3,(H2,24,27)(H,25,28,30)/t15-,16+/m1/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.152n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503932
PNG
(US11034692, Compound 211 | cis-N-(8-amino-6-(2,3-d...)
Show SMILES Nc1nc(cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc12)-c1cncc2NCCc12
Show InChI InChI=1S/C19H17FN6O/c20-14-5-11(14)19(27)26-17-4-9-3-15(25-18(21)12(9)7-24-17)13-6-22-8-16-10(13)1-2-23-16/h3-4,6-8,11,14,23H,1-2,5H2,(H2,21,25)(H,24,26,27)/t11-,14+/m1/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.154n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503956
PNG
(US11034692, Compound 231 | trans-N-(8-amino-6-(4-m...)
Show SMILES Cc1ccncc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3C3CNC(=O)O3)ncc2c(N)n1
Show InChI InChI=1S/C21H20N6O3/c1-10-2-3-23-7-14(10)16-4-11-5-18(24-8-15(11)19(22)26-16)27-20(28)13-6-12(13)17-9-25-21(29)30-17/h2-5,7-8,12-13,17H,6,9H2,1H3,(H2,22,26)(H,25,29)(H,24,27,28)/t12-,13-,17?/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.173n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM503981
PNG
((3R)-3-(4-[[8-amino-6-(4-methylpyridin-3-yl)-2,7-n...)
Show SMILES CN1CC[C@@H](C1=O)n1cc(Nc2cc3cc(nc(N)c3cn2)-c2cnccc2C)cn1
Show InChI InChI=1S/C22H22N8O/c1-13-3-5-24-10-16(13)18-7-14-8-20(25-11-17(14)21(23)28-18)27-15-9-26-30(12-15)19-4-6-29(2)22(19)31/h3,5,7-12,19H,4,6H2,1-2H3,(H2,23,28)(H,25,27)/t19-/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.184n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504040
PNG
((1S,2S)—N-[8-amino-6-[4-methyl-6-(1,3-oxazol-...)
Show SMILES Cc1cc(ncc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3c3cnn(C)c3)ncc2c(N)n1)-c1ncco1
Show InChI InChI=1S/C25H22N8O2/c1-13-5-21(25-27-3-4-35-25)28-10-18(13)20-6-14-7-22(29-11-19(14)23(26)31-20)32-24(34)17-8-16(17)15-9-30-33(2)12-15/h3-7,9-12,16-17H,8H2,1-2H3,(H2,26,31)(H,29,32,34)/t16-,17+/m0/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.184n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM504015
PNG
((1S,2S,3R)—N-[8-amino-6-(4-methylpyridin-3-yl...)
Show SMILES C[C@@H]1[C@@H](CC#N)[C@@H]1C(=O)Nc1cc2cc(nc(N)c2cn1)-c1cnccc1C
Show InChI InChI=1S/C21H20N6O/c1-11-4-6-24-9-15(11)17-7-13-8-18(25-10-16(13)20(23)26-17)27-21(28)19-12(2)14(19)3-5-22/h4,6-10,12,14,19H,3H2,1-2H3,(H2,23,26)(H,25,27,28)/t12-,14-,19-/m1/s1
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.188n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...


US Patent US11034692 (2021)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 420 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%