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Report error Found 2591 Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 4E'
TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM451144(US10676499, Example 1)
Affinity DataKd:  300nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM451146(US10676499, Example 18)
Affinity DataKd:  160nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM451147(US10676499, Example 26)
Affinity DataKd:  6.50E+3nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM451148(US10676499, Example 29)
Affinity DataKd:  6.50E+3nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM451149(US10676499, Example 32)
Affinity DataKd:  30nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM451150(US10676499, Example 33)
Affinity DataKd:  220nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM451151(US10676499, Example 40)
Affinity DataKd:  6.50E+3nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM451152(US10676499, Example 41)
Affinity DataKd:  20nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM451153(US10676499, Example 42)
Affinity DataKd:  6.50E+3nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM451154(US10676499, Example 43)
Affinity DataKd:  580nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM451155(US10676499, Example 49)
Affinity DataKd:  6.50E+3nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM451156(US10676499, Example 53)
Affinity DataKd:  6.00E+3nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM451157(US10676499, Example 54)
Affinity DataKd:  6.00E+3nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM451158(US10676499, Example 55)
Affinity DataKd:  110nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM451159(US10676499, Example 57)
Affinity DataKd:  6.50E+3nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM451160(US10676499, Example 58)
Affinity DataKd:  410nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM50249977(CHEMBL1234304)
Affinity DataKd:  800nMAssay Description:Binding affinity to eIF4E (unknown origin) by fluorescence titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50452630(CHEMBL4203412)
Affinity DataKd:  5.90E+3nMAssay Description:Inhibition of fluorescein-labeled m7GDPC4H5 binding to mouse eIF4E (28 to 217 residues) by MST methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316304(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataKd:  2.00E+3nMAssay Description:Inhibition of fluorescein-labeled m7GDPC4H5 binding to mouse eIF4E (28 to 217 residues) by MST methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM50525087(CHEMBL4577429)
Affinity DataKd:  5.30nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM50525088(CHEMBL4461497)
Affinity DataKd:  21nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM50525089(CHEMBL4464315)
Affinity DataKd:  48nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM50525090(CHEMBL4558213)
Affinity DataKd:  30nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM50525091(CHEMBL4447089)
Affinity DataKd:  5.20nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM50525089(CHEMBL4464315)
Affinity DataKd:  0.0460nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM50525092(CHEMBL4444144)
Affinity DataKd:  123nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM50525088(CHEMBL4461497)
Affinity DataKd:  0.0160nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316305(((2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-...)
Affinity DataKd:  460nMAssay Description:Binding affinity to murine eIF4E assessed as intrinsic fluorescence quenching of tryptophan residues by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316304(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataKd:  1.24E+3nMAssay Description:Binding affinity to murine eIF4E assessed as intrinsic fluorescence quenching of tryptophan residues by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543773(CHEMBL4636472)
Affinity DataKd:  302nMAssay Description:Binding affinity to murine eIF4E assessed as intrinsic fluorescence quenching of tryptophan residues by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543774(CHEMBL4640855)
Affinity DataKd:  344nMAssay Description:Binding affinity to murine eIF4E assessed as intrinsic fluorescence quenching of tryptophan residues by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543775(CHEMBL4640985)
Affinity DataKd:  18nMAssay Description:Binding affinity to murine eIF4E assessed as intrinsic fluorescence quenching of tryptophan residues by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543775(CHEMBL4640985)
Affinity DataKd:  17.7nMAssay Description:Binding affinity to murine eIF4E assessed as intrinsic fluorescence quenching of tryptophan residues by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316303(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataKd:  49nMAssay Description:Binding affinity to murine eIF4E assessed as intrinsic fluorescence quenching of tryptophan residues by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543776(CHEMBL4647306)
Affinity DataKd: >1.00E+4nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543777(CHEMBL4632744)
Affinity DataKd: >1.00E+4nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543777(CHEMBL4632744)
Affinity DataKd: >1.00E+4nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543778(CHEMBL4640425)
Affinity DataKd:  570nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543779(CHEMBL4635767)
Affinity DataKd:  230nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543779(CHEMBL4635767)
Affinity DataKd:  230nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543780(CHEMBL4646578)
Affinity DataKd: >1.00E+4nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316303(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataKd:  70nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM50525088(CHEMBL4461497)
Affinity DataKon:  0.0110M-1s-1Assay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by surface ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM50565475(CHEMBL4777401)
Affinity DataKon:  0.00420M-1s-1Assay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by surface ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM50565476(CHEMBL4780117)
Affinity DataKon:  0.00690M-1s-1Assay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by surface ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM50525088(CHEMBL4461497)
Affinity DataKd:  17nMAssay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM50565475(CHEMBL4777401)
Affinity DataKd:  7.20nMAssay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM50565476(CHEMBL4780117)
Affinity DataKd:  2.20nMAssay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM50607960(CHEMBL5289039)
Affinity DataKd:  2.50E+4nMAssay Description:Binding affinity to EIF4E (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Novartis

US Patent
LigandPNGBDBM50613700(CHEMBL1234303 | CHEBI:50226)
Affinity DataKd:  370nMAssay Description:Inhibition of m7GDP fluorescent probe binding to recombinant eIF4E (unknown origin) assessed as dissociation constant by fluorescence polarization as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
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