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Found 337 with Last Name = 'yoshida' and Initial = 'a'
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127610((1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclo...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50194208((1S,2R)-trans-2-[2-(4-chlorobenzylamino)ethyl]-1-(...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50318106((1S,2R)-2-[(1R)-1-Ethyl-2-(4-chlorobenzylamino)eth...)
Affinity DataKi:  6.70nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50194203((1R,2R)-cis-2-[2-(4-chlorobenzylamino)ethyl]-1-(1H...)
Affinity DataKi:  8.40nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50318103((1R,2S)-2-[(1R)-1-Ethyl-2-(4-chlorobenzylamino)eth...)
Affinity DataKi:  19.8nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50310163((1R,2S)-2-[2-(4-Chlorobenzylamino)ethyl]-1-(5(4)-m...)
Affinity DataKi:  38.7nMAssay Description:Displacement of [3H]Nalpha-methylahistamine from human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  51.1nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50318105((1S,2R)-2-[(1S)-1-Ethyl-2-(4-chlorobenzylamino)eth...)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50318104((1R,2S)-2-[(1S)-1-Ethyl-2-(4-chlorobenzylamino)eth...)
Affinity DataKi:  129nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50310163((1R,2S)-2-[2-(4-Chlorobenzylamino)ethyl]-1-(5(4)-m...)
Affinity DataKi:  148nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50310164((1R,2R)-2-(4-Chlorobenzylamino)methyl-1-(5(4)-meth...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50310164((1R,2R)-2-(4-Chlorobenzylamino)methyl-1-(5(4)-meth...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]Nalpha-methylahistamine from human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 5(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50437693(VIALININ A)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of wild type human USP5 expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 5(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50437693(VIALININ A)
Affinity DataKi:  1.25E+4nMAssay Description:Competitive inhibition of wild type human USP5 expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645016(US20240010658, Example 2)
Affinity DataIC50: <1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645013(US20240010658, Example 1)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645014(US20240010658, Example 1-2)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645029(US20240010658, Example 10)
Affinity DataIC50: <1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645015(US20240010658, Example 1-4)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645017(US20240010658, Example 2-1)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645030(US20240010658, Example 12)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645031(US20240010658, Example 15)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645032(US20240010658, Example 16)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645022(US20240010658, Example 3-9)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645023(US20240010658, Example 3-10)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645027(US20240010658, Example 8-1)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645026(US20240010658, Example 6-2)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645024(US20240010658, Example 5)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645018(US20240010658, Example 2-6)
Affinity DataIC50:  2nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM514134(US11052091, Example 5-16)
Affinity DataIC50:  2nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645025(US20240010658, Example 6)
Affinity DataIC50:  2nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645021(US20240010658, Example 3-6)
Affinity DataIC50:  2nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645019(US20240010658, Example 2-14)
Affinity DataIC50:  2nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM514126(US11052091, Example 5-1)
Affinity DataIC50:  2nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645028(US20240010658, Example 9)
Affinity DataIC50:  2nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM514137(US11052091, Example 5-19)
Affinity DataIC50:  3nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM514136(US11052091, Example 5-18)
Affinity DataIC50:  3nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM514135(US11052091, Example 5-17)
Affinity DataIC50:  3nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50003815(CHEMBL3235321)
Affinity DataIC50:  3nMAssay Description:Inhibition of DGAT1 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM27947(2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of DGAT1 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50003815(CHEMBL3235321)
Affinity DataIC50:  4nMAssay Description:Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM514138(US11052091, Example 5-21)
Affinity DataIC50:  5nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645020(US20240010658, Example 3)
Affinity DataIC50:  5nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM514124(US11052091, Example 3)
Affinity DataIC50:  5nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM514127(US11052091, Example 5-2)
Affinity DataIC50:  5nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50003860(CHEMBL3235317)
Affinity DataIC50:  5nMAssay Description:Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM514129(US11052091, Example 5-4)
Affinity DataIC50:  6nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM514128(US11052091, Example 5-3)
Affinity DataIC50:  6nMAssay Description:Measurement of an inhibitory activity on Brk enzyme was performed by using LanthaScreen (registered trademark) system (Invitrogen) in accordance with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50003858(CHEMBL3235315)
Affinity DataIC50:  6nMAssay Description:Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM27947(2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPAMore data for this Ligand-Target Pair
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