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Zhao, L; Girijavallabhan, VM; Rosner, KE; Lavey, BJ; Rizvi, R; Shankar, BB; Wong, MK; Guo, Z; Orth, P; Strickland, CO; Sun, J; Niu, X; Chen, S; Kozlowski, JA; Lundell, DJ; Piwinski, JJ; Shih, NY; Siddiqui, MA Bioorg Med Chem Lett 21: 3172 -6 (2011) Peng, X; Lanter, JC; Y-P Chen, A; Brand, MA; Wozniak, MK; Hoekman, S; Longin, O; Regeling, H; Zonneveld, W; P L Bell, R; Koenig, G; Hurst, RS; Blain, JF; Burnett, DA Bioorg Med Chem Lett 80: (2023) Sun, WX; Han, HW; Yang, MK; Wen, ZL; Wang, YS; Fu, JY; Lu, YT; Wang, MY; Bao, JX; Lu, GH; Qi, JL; Wang, XM; Lin, HY; Yang, YH Bioorg Med Chem 27: (2019) Yau, MK; Suen, JY; Xu, W; Lim, J; Liu, L; Adams, MN; He, Y; Hooper, JD; Reid, RC; Fairlie, DP ACS Med Chem Lett 7: 105 -10 (2016) Lee, RE; Tangallapally, RP; Rock, CO; Jackowski, S; Edwards, AV; Yun, MK; Subramanian, C; Zamboni, R; Reddy, TJ US Patent US11891378 (2024) Paige, M; Kosturko, G; Bulut, G; Miessau, M; Rahim, S; Toretsky, JA; Brown, ML; Üren, A Bioorg Med Chem 22: 478 -87 (2013) Abdel-Hamid, MK; 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Hassan, HY; Mahfouz, NM; Farag, HH; Bekhit, AA Eur J Med Chem 93: 481 -91 (2015) Peluso, S; de L Ufret, M; O'Reilly, MK; Imperiali, B Chem Biol 9: 1323 -8 (2002)
US9475819, 220 US9637496, 220 BDBM164090 US9062078, 220 US9695183, 220
US11667644, Example 220 USRE48841, Example 220 US9586962, Example 220 US8653263, 220 BDBM118567 US11059828, Example 220
US9688629, 220 US10604504, Example 220 US11623921, Example 220 US9920031, Example 220 US9802915, Example 220 BDBM166736
BDBM150546 US10238633, Example 220 US9713606, 220 US8987249, 220
US10213433, Compound 220 US9174982, 220 US20240043404, Example 220 BDBM189653 US11369599, Compound 220
US10703749, Example 220 BDBM254320 US10112937, Example 220 US9464084, 220 US10150765, Example 220
US10881652, Example 220 BDBM305204 US10172845, Example 220 US10441581, Example 220 US10144734, Example 220 US11648243, Example 220
US11548872, Compound 220 US10106527, Compound 220 US10544128, Compound 220 BDBM293538 US9951048, Compound 220 US20230286945, Compound 220
BDBM344505 US9782415, Example 220 US10251889, Example 220 US9796724, Example 220 US10758542, Example 220
US10307413, Compound 220 US10980794, Cmpd No 220 US10391089, Compound 220 BDBM178895 US9675614, 220
US11220509, Example 220 BDBM513858 US11091495, Example 220 US20240398811, Example 220 US11485738, Example 220
BDBM268188 US10772893, Example 220 US11529356, Example 220 US9549932, 220
US9321760, 220 US9662330, Compound 220 BDBM224537 US10080750, Compound 220
US9452980, 220 US10501411, Example 220 US11697636, Example 220 BDBM250310
US9745328, Compound 220 US9884878, Compound 220 BDBM168821 US9079866, 220
BDBM145032 US8952157, 220 US9303025, 220
BDBM165185 US9682971, 220 US9067917, 220
BDBM197620 US9216968, 220 US9732066, 220
BDBM71081 US9546164, 220 US9694002, 220
US10047103, 220 US9688695, 220 BDBM176187
US8546380, 220 BDBM103380 US8633188, 220
US8546380, 220 BDBM34542 US8633188, 220
US9242973, 220 US8975415, 220 BDBM149938
BDBM244611 US20250017938, Compound 002-220 US10226449, cpd 220 US9428502, 220
BDBM343621 US10442803, Example 220 US9777003, Example 220 US11091484, Example 220
BDBM365503 US10533001, Example 220 US11414410, Example 220 US9868729, Example 220
BDBM403067 US10793579, Example 220 US11702424, Example 220 US10329302, Example 220
BDBM431275 US10870641, Example 220 US11014913, Example 220 US10550105, Example 220
US10172864, Compound 220 US10028961, Compound 220 US10946023, Compound 220 BDBM280067
US10604535, Example 220 US9815850, Compound 220 US9896458, No. 220 BDBM356485
US10988451, Example 220 US10703733, Example 220 BDBM449607 US11643400, Example 220
US20240101536, Example 220 US12240835, Example 220 US10889571, Example 220 BDBM477872
US9999619, Example 220 US11285140, Example 220 US10695337, Example 220 BDBM400465
BDBM127790 US11547697, Compound 220 US9682141, 220
BDBM215260 US9296736, 220 US9593129, Example 220
BDBM241588 US9409908, 220 US9951071, Example 220
BDBM244984 US9738649, Example 220 US9422293, 220
US8916576, 220 BDBM141015 US10570123, Example 220
US9073922, 220 BDBM167733 US9796708, Example 220
US9216999, 220 US9556187, Example 220 BDBM198423
US9573943, Example 220 US8669361, 220 BDBM119401
US9604984, Example 220 US9346815, 220 BDBM232674
US9682966, 220 US10118915, Compound 220 BDBM156425
US9732093, Compound 220 US9073876, 220 BDBM167138
US10618902, Compound I-220 US10189794, Compound I-220 US10774052, Compound I-220 BDBM100462 US9695132, I-220
MK-52 MK-51 CHEMBL2092821 BDBM50451497
BDBM397256 US9987276, Compound I-220 US10828300, Compound I-220 US10596172, Compound I-220 US11351168, Compound I-220
US9688672, Example 220 US9434719, 220 as TFA salt BDBM247618 US10112931, Example 220
BDBM137152 US8871790, 220 US20250017938, Compound 001-220
BDBM273437 US10478424, Example 220 US10071079, Example 220
BDBM284210 US10174028, Example 220 US10023570, Example 220
BDBM348497 US9790229, Compound 220 US10577374, Compound 220
BDBM486768 US11427601, Example 220 US10947252, Example 220
BDBM50045598 CHEMBL3314311 US9540323, 220 US9540323, example 220
BDBM561683 US11390631, Example 220 US12268694, Example 220
BDBM578372 US11478474, Compound 220 US12070457, Compound 220
BDBM586042 US11530237, Compound 220 US11542297, Compound 220
US10072001, Example 220 BDBM277029 US10259811, Example 220
US10105367, Example 220 BDBM292934 US10376514, Example 220
US10125118, Example 220 US10947215, Example 220 BDBM298814
US10214492, Example 220 US11292767, Example 220 BDBM356870
US10301317, Example 220 US9624228, Example 220 BDBM318264
US10562891, Example 220 BDBM434300 US11008308, Example 220
US10723742, Example 220 BDBM456493 US11510915, Example 220
US10800783, Example 220 US11396512, Example 220 BDBM467228
US11248001, Example 220 US11603523, Example 220 BDBM537801
US11453683, Example 220 BDBM573651 US20230279025, Example 220
US11555029, No. 220 US10710986, Example 220 BDBM452081
US8604016, 220 US9938267, Cmpd ID 220 BDBM108645
BDBM50485492 MK-5172 MK-5172 MONOHYDRATE Grazoprevir monohydrate Grazoprevir MK-5172 ANHYDROUS
BDBM423765 US11046698, Compound I-220 US10508120, Compound I-220 US10577373, Compound I-220
US10323036, Compound I-220 US10793574, Compound I-220 US11220508, Compound I-220 BDBM399733
BDBM195157 US10336717, Compound 220 US9212153, 220,Ex. 178
MK-2461 CHEMBL1802916 BDBM50347659 US20250129067, Compound MK 2461
BDBM464624 US11117900, Compound I-N-220 US20230271963, Compound I-N-220 US11370798, Cmpd. # I-N-220 US10787452, Compound I-N-220
BDBM390612 US9957235, 2-220 US10442772, Example 2-220-2
BDBM439911 US20230279020, Example 220-1a US10633389, Example 220-1a
BDBM440554 US20230279020, Example 220-3 US10633389, Example 220-3
BDBM454483 US10882866, Example Ib-220 US10717742, Example Ib-220
BDBM455203 US10730874, Compound I-220 US11352356, Compound I-220
BDBM565654 US12221453, Compound I-220 US11414431, Compound I-220
US10533010, Example I-220 US11208415, Example I-220 BDBM429118
US10597377, Compound 2-220 BDBM405750 US10351547, Compound 2-220
US11345716, Compound III-220 US10870660, Compound III-220 BDBM476790
US11396508, Compound I-220 BDBM442259 US10647713, Compound I-220
US9732060, Compound I-220 US10065941, Compound I-220 BDBM271980
US9732060, Compound R-220 BDBM271905 US10065941, Compound R-220
US9751854, Compound I-220 BDBM338045 US9802960, Compound I-220
(R)-N-(1-cyanopyrrolidin-3-yl)-3-(3, 4-dimethoxyphenyl)isoxazole-5-carboxamide US11066365, Example 220 US11390584, Example 220 US10343992, Example 220 US10689345, Example 220 BDBM404568 US11053198, Example 220
BDBM311363 US10723734, Example 220 US9902722, Example 220 US10351563, Example 220 US10155760, Example 220 US10981910, Example 220 US10544120, Example 220 (S)-methyl (6-((2-amino-2,4-dimethylpentyl)oxy)-5-(trifluoromethyl)-[3,4′-bipyridin]-2′-yl)carbamate
BDBM103243 US8541407, 220
BDBM104800 US8569308, 220
BDBM109477 US8604061, 220
BDBM115395 US8637500, 220
BDBM117893 US9682940, 220
BDBM121781 US8722692, 220
BDBM125825 US8772305, 220
BDBM127847 US8791123, 220
BDBM128631 US8796244, 220
BDBM129127 US8802674, 220
BDBM129939 US8815926, 220
BDBM133530 US8846719, 220
BDBM134757 US8846698, 220
BDBM144019 US8969325, 220
BDBM145441 US8952169, 220
BDBM146168 US8957068, 220
BDBM147383 US8957093, 220
BDBM151784 US8987445, 220
BDBM153073 US8993616, 220
BDBM155781 US9012651, 220
BDBM156169 US9018214, 220
BDBM156791 US9029559, 220
BDBM157379 US9023865, 220
BDBM161782 US9682976, 220
BDBM169611 US9675593, 220
BDBM169871 US9073940, 220
BDBM170792 US9085555, 220
BDBM175675 US9688680, 220
BDBM180663 US8772323, 220
BDBM182017 US9145380, 220
BDBM184336 US9150577, 220
BDBM186552 US9163021, 220
BDBM187669 US9169252, 220
BDBM188680 US9169246, 220
BDBM188954 US9169260, 220
BDBM191450 US9181272, 220
BDBM199584 US9226922, 220
BDBM201789 US9233979, 220
BDBM203664 US9221809, 220
BDBM204510 US9242996, 220
BDBM205751 US9255090, 220
BDBM210508 US9290451, 220
BDBM214942 US9296734, 220
BDBM215028 US9296734, 220
BDBM215649 US9296745, 220
BDBM220631 US9296741, 220
BDBM229893 US9334269, 220
BDBM234090 US9353090, 220
BDBM234534 US9353089, 220
BDBM238573 US9394297, 220
BDBM247361 US9447091, 220
BDBM248363 US9434711, 220
BDBM250916 US9452986, 220
BDBM253260 US9458171, 220
BDBM255469 US9481682, 220
BDBM256039 US9481672, 220
BDBM257372 US9493440, 220
BDBM302308 US9598415, 220
BDBM70515 US9693992, 220
BDBM70701 US9693997, 220
BDBM77108 CMX157-220
BDBM98408 US8481733, 220
BDBM98894 US8497265, 220
BDBM99442 US8497281, 220
US8486940, 220 BDBM65019
US8487093, 220 BDBM98823
US8530648, 220 BDBM102283
US8569281, 220 BDBM105178
US8575186, 220 BDBM104441
US8623889, 220 BDBM112222
US8623901, 220 BDBM111892
US8633204, 220 BDBM113498
US8759532, 220 BDBM124542
US8778951, 220 BDBM126410
US8791131, 220 BDBM127446
US8822448, 220 BDBM130788
US8841312, 220 BDBM132471
US8853258, 220 BDBM135567
US8871934, 220 BDBM137627
US8912224, 220 BDBM140788
US8916553, 220 BDBM140961
US8987268, 220 BDBM151068
US9012443, 220 BDBM154207
US9023882, 220 BDBM157933
US9034866, 220 BDBM158745
US9067871, 220 BDBM164744
US9067922, 220 BDBM165881
US9067949, 220 BDBM166363
US9102637, 220 BDBM174185
US9120812, 220 BDBM178435
US9125913, 220 BDBM178654
US9145392, 220 BDBM182519
US9145414, 220 BDBM182806
US9150526, 220 BDBM183957
US9156845, 220 BDBM185560
US9163007, 220 BDBM185868
US9187424, 220 BDBM201454
US9260425, 220 BDBM206473
US9260439, 220 BDBM207243
US9266876, 220 BDBM208753
US9266883, 220 BDBM209363
US9278981, 220 BDBM213628
US9283222, 220 BDBM214157
US9302989, 220 BDBM216020
US9321756, 220 BDBM224953
US9328096, 220 BDBM226527
US9328106, 220 BDBM227269
US9340517, 220 BDBM231833
US9346798, 220 BDBM231473
US9365576, 220 BDBM236464
US9409866, 220 BDBM240505
US9434725, 220 BDBM248989
US9458110, 220 BDBM252148
US9458176, 220 BDBM252823
US9493446, 220 BDBM257751
US9533985, 220 BDBM65433
US9663469, 220 BDBM327673
US9695149, 220 BDBM102759
BDBM415892 US10442772, Example 2-220-1 US10442772, Example 2-220
BDBM103838 MK-5172
BDBM50566358 Mk-8666
MK-8189 BDBM50616544
Mk-0752 BDBM50458158
MK-24(S)-S(O)(NH)Ph BDBM50214607 CHEMBL541423 MK-24
BDBM105710 US8575197, I-220
BDBM106307 US8575197, II-220
BDBM115836 US8633183, D-220
BDBM116071 US8633183, E-220
BDBM122750 US8735386, I-220
BDBM147896 US8962608, 28-220
BDBM228082 US9556160, ex 220
BDBM268815 US9718825, Example 220
BDBM272376 US10065950, Example 220
BDBM280325 US10029993, Example 220
BDBM282673 US9884828, 11-220
BDBM294746 US10112899, Example 220
BDBM317444 US9617282, Example 220
BDBM326523 US9662327, Compound 220
BDBM331799 US9725465, Example 220
BDBM341986 US9771320, Example 220
BDBM390333 US9951086, Example 220
BDBM411010 US10383880, Example 220
BDBM417361 US10457654, Example 220
BDBM427787 US10544143, Example 220
BDBM437950 US10597366, Compound 220
BDBM438653 US10618903, Example 220
BDBM450917 US10676469, Compound 220
BDBM451622 US10710967, Example 220
BDBM479281 US10894789, Compound 220
BDBM484969 US10934302, Example 220
BDBM489966 US10966980, Example 220
BDBM512626 acs.jmedchem.1c00409_ST.220
BDBM516130 US11053226, Example 220
BDBM523729 US11136311, Compound 220
BDBM527242 US11186582, Example 220
BDBM528539 US11192859, Compound 220
BDBM529814 US11203591, Example 220
BDBM541616 US11267811, Example 220
BDBM544736 US11286268, Compound 220
BDBM555544 US11344549, Example 220
BDBM583097 US11548892, Compound 220
BDBM584472 US11524968, Example 220
BDBM586197 US11530244, Compound 220
BDBM587971 US11535621, Example 220
BDBM589974 US11559538, Example 220
BDBM596564 US11596639, Example 220
BDBM603247 US11649255, Example 220
BDBM607280 US11685745, Example 220
BDBM612958 US11725000, Compound 220
BDBM615429 US20230271949, Example 220
BDBM617988 US20230286970, Compound 220
BDBM618008 US20230286958, Example 220
BDBM622260 US20230312550, Example 220
BDBM623202 US11780845, Example 220
BDBM631283 US11802133, Example 220
BDBM631950 US20230348426, Example 220
BDBM634771 US11814367, Compound 220
BDBM637305 US20230382904, Compound 220
BDBM638117 US11834453, Example 220
BDBM638625 US11834467, Example 220
BDBM641326 US11845723, Example 220
BDBM647981 US20240025919, Compound 220
BDBM655472 US11912703, Example 220
BDBM658408 US20240083900, Example 220
BDBM659103 US20240092758, Example 220
BDBM665536 US20240116910, Compound 220
BDBM666187 US20240116946, Example 220
BDBM669233 US11964973, Example 220
BDBM669818 US20240132480, Example 220
BDBM670276 US11970474, Example 220
BDBM670671 US20240140931, Compound 220
BDBM677913 US20240174674, Compound 220
BDBM678494 US20240174696, Compound 220
BDBM681661 US20240199605, Example 220
BDBM681977 US20240199649, Compound 220
BDBM686068 US20240245673, Example 220
BDBM689745 US20240262804, Example 220
BDBM695054 US20240294551, Example 220
BDBM702467 US20240360148, Example 220
BDBM703273 US20240368104, Example 220
BDBM715056 US20250026748, Compound 220
BDBM716236 US12209085, Example 220
BDBM716782 US20250034135, Compound 220
BDBM718365 US20250042889, Example 220
BDBM722887 US20250059218, Compound 220
BDBM723107 US20250059220, Compound 220
BDBM723646 US20250064789, Compound 220
BDBM724281 US20250066350, Example 220
BDBM731007 US20250122183, Example 220
BDBM733921 US20250127903, Compound 220
BDBM734675 US20250129067, Compound 220
BDBM735202 US20250129078, Compound 220
BDBM735633 US20250129103, Compound 220
BDBM736735 US20250136570, Compound 220
BDBM738997 US20250145633, Example 220
BDBM745740 US12319655, Example 220
BDBM747050 US20250179047, Example 220
BDBM749598 US12331033, Example 220
BDBM750568 US20250195475, Example 220
BDBM751954 US20250197382, Compound 220
BDBM753807 US20250206717, Example 220
BDBM756930 US20250221979, Example 220
BDBM759628 US20250236608, Example 220
BDBM761884 US12378224, Example 220
BDBM765591 US12391697, Example 220
US10022354, Example 220 BDBM281280
US10092570, Example 220 BDBM289219
US10189854, Compound 220 BDBM332257
US10201546, Example 220 BDBM339377
US10202339, Compound 220 BDBM339443
US10214519, Example 220 BDBM357476
US10221177, Compound 220 BDBM361847
US10227329, Compound 220 BDBM367808
US10251893, Cpd 220 BDBM375024
US10287286, Example 220 BDBM385821
US10323022, Example 220 BDBM398743
US10435369, Example 220 BDBM414333
US10544136, Compound 220 BDBM427436
US10562878, Compound 220 BDBM433899
US10626095, Example 220 BDBM610847
US10660877, Example 220 BDBM443636
US10766903, Example 220 BDBM462608
US10844044, Example 220 BDBM473342
US10899735, No. 220 BDBM479761
US10975056, Example 220 BDBM491273
US10981917, Example 220 BDBM493519
US11021493, Example 220 BDBM501301
US11028090, Example 220 BDBM502326
US11053213, Example 220 BDBM514478
US11136296, Example 220 BDBM523489
US11149018, Example 220 BDBM520939
US11174245, # I-220 BDBM525542
US11208404, Compound 220 BDBM532138
US11225469, Compound 220 BDBM533721
US11292791, Example 220 BDBM546947
US11420970, Example 220 BDBM568018
US11420973, Example 220 BDBM568342
US11433053, Example 220 BDBM570324
US11591336, Compound 220 BDBM596177
US11654147, Compound 220 BDBM603783
US11697648, Example 220 BDBM608652
US11773078, Example 220 BDBM621468
US11807646, Example 220 BDBM633806
US11897851, Compound 220 BDBM570673
US11912686, Compound 220 BDBM654275
US11964953, Example 220 BDBM668956
US11999676, Compound 220 BDBM679357
US12128028, Example 220 BDBM701824
US12173018, Example 220 BDBM708284
US12338220, Example 220 BDBM753222
US12384753, Example 220 BDBM763197
US20230312605, Compound 220 BDBM622701
US20230339915, Compound 220 BDBM629238
US20230348450, Example 220 BDBM632834
US20240025884, Example 220 BDBM647009
US20240101572, Example 220 BDBM661611
US20240116877, Example 220 BDBM664947
US20240174662, Example 220 BDBM677556
US20240207300, Compound 220 BDBM682471
US20240218021, Example 220 BDBM684248
US20240246964, Compound 220 BDBM687199
US20240287079, Example 220 BDBM694049
US20240316047, Example 220 BDBM697438
US20240374606, Example 220 BDBM704667
US20250032489, Compound 220 BDBM716317
US20250059156, Compound 220 BDBM721520
US20250059174, Example 220 BDBM721957
US20250074911, Example 220 BDBM726014
US20250084074, Example 220 BDBM726906
US20250122174, Example 220 BDBM730638
US20250145606, Example 220 BDBM738661
US20250170122, Compound 220 BDBM744296
US20250188079, Compound 220 BDBM749167
US20250243180, Compound 220 BDBM761228
US8653087, III-220 BDBM117540
US8772480, 220 CHEMBL2165034 BDBM50394856
US9193689, IQ-220 BDBM192908
US9242970, 220 CHEMBL3113537 BDBM50447777
US9359338, Exe. 220 BDBM235610
US9546153, ex. 220 BDBM209980
US9745291, Compound 220 BDBM337174
US9777008, Compound 220 BDBM343926
US9790221, Compound 220 BDBM348012
US9873693, Compound 220 BDBM366296
US9884814, Compound 220 BDBM275617
US9969687, Compound 220 BDBM393551
WO2022091056, Example 220 BDBM548229
US10646492, Example 220 BDBM261197 US9932341, Example 220 US11433071, Example 220 4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-6-chloro-3-ethoxy-2-{1-[(2S)-2-hydroxypropyl]azetidin-3-yl}benzonitrile US10376513, Example 220 US9730939, Example 220 US9707233, 220
BDBM50360601 MK-0893 CHEMBL1933349
BDBM50368906 MK-386 CHEMBL25448
BDBM50373120 MK-0364 CHEMBL260977
BDBM50381914 CHEMBL2023109 MK-7725
BDBM50423686 CHEMBL506044 MK-0668
BDBM50427138 MK-8033 CHEMBL2323775
BDBM50479471 MK-1107 CHEMBL491019
CHEMBL253364 BDBM50230827 MK-9
CHEMBL489586 BDBM50479470 MK-4965
MK 0893 BDBM50168081 CHEMBL3799802
MK-0617 CHEMBL566154 BDBM50423695
MK-1220 CHEMBL1672609 BDBM50485489
MK-50 CHEMBL2113644 BDBM50451496
MK-55 BDBM50474237 CHEMBL313379
MK-7445 BDBM50484630 CHEMBL1939502
MK-8742 BDBM50531952 Elbasvir
MK-991 BDBM50366679 CHEMBL1793852
Mk-2748 BDBM50642717 MK2748
Mk-6186 Mk6186 BDBM50484632
BDBM50004205 TOZASERTIB MK-045 MK-0457 US9249124, VX680 VX-68 VX-680
BDBM414803 US10435405, Example 220 US10934288, Example 220 US10435405, Example 239 US10435405, Example 238
6-(2-methoxyethoxy)-4- (6-(4-((2- methylpyridin-4- yl)methyl)piperazin-1- yl)pyridin-3- yl)pyrazolo[1,5- a]pyridine-3- carbonitrile US10137124, Example 220 US10112942, Example 220 BDBM296486 US10555944, Example 220 US10953005, Example 220 US10172851, Example 220
BDBM104718 US8569308, 138 US8569308, 220
BDBM640665 US20230399319, Example 2-220
BDBM727359 US20250090540, Example I-220
BDBM728603 US20250092056, Compound I-220
BDBM741552 US20250162989, Compound I-220
BDBM744620 US20250170126, Compound I-220
CHEMBL3943463 US9763922, Example 220 BDBM50200457
US10793568, Compound I-220 BDBM465570
US11753403, Compound I-220 BDBM617169
US12053473, Example I-220 BDBM689385
US9695118, 221 BDBM77688 US9695118, 220