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TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 762982BDBM762982(N-{5-[3- (cyclopropylsulfonyl)phenyl]-3- fluoropyr...)
Affinity DataIC50: 10nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50070103BDBM50070103((E)-1-(2',5'-Dimethoxyphenyl)-3-(4''-N,N-Dimethyla...)
Affinity DataIC50: 12nMAssay Description:Tested for inhibition of polymerization of tubulinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 762977BDBM762977(N-{5-[3- (cyclopropylsulfonyl)phenyl]-6- methylpyr...)
Affinity DataIC50: 120nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50112256BDBM50112256(3,4,5-Trimethoxy-benzaldehyde O-(8-hydroxy-5-methy...)
Affinity DataIC50: 170nMAssay Description:Ability to inhibit the GTP/glutamate-induced polymerization of tubulinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50012278BDBM50012278(VINBLASTINE SULFATE | (2ALPHA,2''BETA,3BETA,4ALPHA...)
Affinity DataIC50: 200nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50139772BDBM50139772(leurocristine | 22-oxovincaleukoblastine | vincris...)
Affinity DataIC50: 220nMAssay Description:The compound was evaluated in vitro for the mammalian brain tubulin polymerization using standard assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2012
Entry Details Article

TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50455100BDBM50455100(CHEMBL4105066 | US12383533, Compound 63)
Affinity DataIC50: 240nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50455101BDBM50455101(CHEMBL4217112 | US12383533, Compound 61)
Affinity DataIC50: 260nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 762974BDBM762974(6-methyl-N-{5-[3-(oxetan-3- yl)phenyl]pyridin-2-yl...)
Affinity DataIC50: 300nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50280140BDBM50280140([6-(3,4,5-Trimethoxy-benzyloxy)-imidazo[1,2-b]pyri...)
Affinity DataIC50: 310nMAssay Description:In vitro mammalian brain tubulin polymerization using standard assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2012
Entry Details Article

TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 762973BDBM762973(N-{5-[3- (cyclopropylamino)phenyl]pyridin- 2-yl}-2...)
Affinity DataIC50: 320nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50037463BDBM50037463(2-(3-Methoxy-phenyl)-6-morpholin-4-yl-1H-quinolin-...)
Affinity DataIC50: 363nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50037454BDBM50037454(6-(3-Chloro-phenyl)-5H-[1,3]dioxolo[4,5-g]quinolin...)
Affinity DataIC50: 372nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50037448BDBM50037448(6-Dimethylamino-2-(3-methoxy-phenyl)-1H-quinolin-4...)
Affinity DataIC50: 380nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50037450BDBM50037450(2-(3-Methoxy-phenyl)-6-pyrrolidin-1-yl-1H-quinolin...)
Affinity DataIC50: 437nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50409014BDBM50409014(CHEMBL50139)
Affinity DataIC50: 447nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50106309BDBM50106309(2-(2-fluorophenyl)-6-(pyrrolidin-1-yl)quinolin-4(1...)
Affinity DataIC50: 457nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50035218BDBM50035218(podophyllotoxin | CHEMBL61 | Podophyllinic acid la...)
Affinity DataIC50: 460nMAssay Description:Inhibition of tubulin polymerization. (ITP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50037462BDBM50037462(6-(3-Hydroxy-phenyl)-5H-[1,3]dioxolo[4,5-g]quinoli...)
Affinity DataIC50: 468nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 762970BDBM762970(N-[5-(3-cyclopropylphenyl)pyridin- 2-yl]pyrimidine...)
Affinity DataIC50: 480nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50070107BDBM50070107((E)-3-(3''-Hydroxy-4''-methoxyphenyl)-2-methyl-1-(...)
Affinity DataIC50: 500nMAssay Description:Concentration that cause a 50% inhibition in tubulin assembly as measured by an increase in turbidity using microtubule assembly assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50037457BDBM50037457(6-(3-Fluoro-phenyl)-5H-[1,3]dioxolo[4,5-g]quinolin...)
Affinity DataIC50: 525nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50059968BDBM50059968(2-(3-fluorophenyl)-7-methyl-1,8-naphthyridin-4(1H)...)
Affinity DataIC50: 525nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50005480BDBM50005480(combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...)
Affinity DataIC50: 530nMAssay Description:Inhibition of tubulin polymerization (ITP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50059964BDBM50059964(6-methyl-2-(naphthalen-1-yl)-1,8-naphthyridin-4(1H...)
Affinity DataIC50: 550nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50056948BDBM50056948(Isonicotinic acid 1,2,3-trimethoxy-10-methylsulfan...)
Affinity DataIC50: 562nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50037444BDBM50037444(6-(3-Methoxy-phenyl)-5H-[1,3]dioxolo[4,5-g]quinoli...)
Affinity DataIC50: 575nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A/beta chain(Pig)
University of Manchester

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50095321BDBM50095321(2-Methoxy-5-(3,4,5-trimethoxy-benzyloxy)-benzaldeh...)
Affinity DataIC50: 600nMAssay Description:Effect on tubulin binding and the concentration required to cause 50% decrease in tubulin assembly at 350 nm.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2018
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50409024BDBM50409024(CHEMBL48525)
Affinity DataIC50: 617nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50059971BDBM50059971(2-(3-Fluoro-phenyl)-6-methyl-1H-[1,8]naphthyridin-...)
Affinity DataIC50: 631nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50009568BDBM50009568((Thiocolchicine)N-(1,2,3-Trimethoxy-10-methylsulfa...)
Affinity DataIC50: 646nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50037459BDBM50037459(6-(3-Methylamino-phenyl)-5H-[1,3]dioxolo[4,5-g]qui...)
Affinity DataIC50: 646nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50059966BDBM50059966(7-Methyl-2-naphthalen-1-yl-1H-[1,8]naphthyridin-4-...)
Affinity DataIC50: 661nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50041119BDBM50041119(2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-on...)
Affinity DataIC50: 680nMAssay Description:Inhibition of tubulin polymerization (ITP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50139772BDBM50139772(leurocristine | 22-oxovincaleukoblastine | vincris...)
Affinity DataIC50: 680nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50455099BDBM50455099(CHEMBL4079324 | US12383533, Compound 27)
Affinity DataIC50: 680nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50063845BDBM50063845((S)-6-(3-Methoxy-phenyl)-6,7-dihydro-5H-[1,3]dioxo...)
Affinity DataIC50: 692nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50009568BDBM50009568((Thiocolchicine)N-(1,2,3-Trimethoxy-10-methylsulfa...)
Affinity DataKi:  700nMAssay Description:Compound was evaluated for its ability to inhibit the binding of [3H]-colchicine to tubulin in competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50409011BDBM50409011(CHEMBL45711)
Affinity DataIC50: 724nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50037453BDBM50037453(6-(3-Amino-phenyl)-5H-[1,3]dioxolo[4,5-g]quinolin-...)
Affinity DataIC50: 724nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50059961BDBM50059961(2-(3-Chloro-phenyl)-6-methyl-1H-[1,8]naphthyridin-...)
Affinity DataIC50: 724nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50059975BDBM50059975(2-(3-Fluoro-phenyl)-5,7-dimethyl-1H-[1,8]naphthyri...)
Affinity DataIC50: 741nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50280009BDBM50280009(N-(1,2,3-Trimethoxy-10-methylamino-9-oxo-5,6,7,9-t...)
Affinity DataKi:  750nMAssay Description:Compound was evaluated for its ability to inhibit the binding of [3H]-colchicine to tubulin in competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50280140BDBM50280140([6-(3,4,5-Trimethoxy-benzyloxy)-imidazo[1,2-b]pyri...)
Affinity DataKi:  750nMAssay Description:Compound was tested for competitive inhibition with radioligand [3H]colchicine at colchicine site of mammalian tubulinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2012
Entry Details Article

TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50056949BDBM50056949(Nicotinic acid 1,2,3-trimethoxy-10-methylsulfanyl-...)
Affinity DataIC50: 759nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50059117BDBM50059117(2-(3-Methoxy-phenyl)-7-methyl-1H-[1,8]naphthyridin...)
Affinity DataIC50: 759nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50059978BDBM50059978(5,7-Dimethyl-2-naphthalen-1-yl-1H-[1,8]naphthyridi...)
Affinity DataIC50: 776nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50059976BDBM50059976(2-(3-Chloro-phenyl)-5,7-dimethyl-1H-[1,8]naphthyri...)
Affinity DataIC50: 776nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50059111BDBM50059111(2-(3-Methoxy-phenyl)-6-methyl-1H-[1,8]naphthyridin...)
Affinity DataIC50: 794nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
Frost Biologic

US Patent
LigandChemical structure of BindingDB Monomer ID 50014846BDBM50014846(7alphaH-colchicine | (S)-N-(5,6,7,9-tetrahydro-1,2...)
Affinity DataIC50: 800nMAssay Description:Inhibition of tubulin polymerization (ITP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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